SIMILAR PATTERNS OF AMINO ACIDS FOR 1UYU_A_CAMA1416_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 LEU A  84
VAL A  48
THR A 415
ASP A  51
 None
None
None
GLC  A 550 (-3.1A)
 1.15A 1uyuA-1b1yA:
undetectable		 1uyuA-1b1yA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 THR A  95
LEU A  93
VAL A 174
THR A 141
 None
PTT  A 800 (-4.6A)
None
None
 1.06A 1uyuA-1b25A:
0.0		 1uyuA-1b25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		4 LEU A  86
VAL A  50
THR A 417
ASP A  53
 None
 1.15A 1uyuA-1btcA:
undetectable		 1uyuA-1btcA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 LEU A 385
VAL A 381
THR A 314
ASP A 342
 None
 0.97A 1uyuA-1h39A:
0.0		 1uyuA-1h39A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 396
LEU A 345
VAL A 257
VAL A 404
 None
 1.11A 1uyuA-1mb9A:
undetectable		 1uyuA-1mb9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1

(Sus scrofa) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		4 LEU A 197
VAL A 237
VAL A 308
ASP A 300
 None
 1.17A 1uyuA-1px5A:
0.0		 1uyuA-1px5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 THR A 263
LEU A 303
VAL A 307
VAL A 244
 None
 1.19A 1uyuA-1vbmA:
undetectable		 1uyuA-1vbmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm0 UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01918
(Alba) 		4 THR A  65
LEU A 104
VAL A  49
VAL A  25
 None
 1.14A 1uyuA-1vm0A:
undetectable		 1uyuA-1vm0A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 THR A 131
LEU A 205
VAL A 201
THR A 231
 None
 1.17A 1uyuA-1vpkA:
undetectable		 1uyuA-1vpkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk4 TTK003001606

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.19A 1uyuA-1wk4A:
undetectable		 1uyuA-1wk4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  27
THR H  94
LEU H   4
VAL H  71
 None
 1.12A 1uyuA-1xgyH:
undetectable		 1uyuA-1xgyH:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 TYR A  16
VAL A  53
THR A  72
ASP A  10
 None
None
None
MG  A 500 (-2.8A)
 1.10A 1uyuA-1ydfA:
undetectable		 1uyuA-1ydfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
 SAZ  A 709 (-4.9A)
None
None
None
 0.94A 1uyuA-1yyrA:
undetectable		 1uyuA-1yyrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9j GREEN FLUORESCENT
PROTEIN FP512

(Cerianthus
membranaceus) 		PF01353
(GFP) 		4 PHE A  38
LEU A 196
THR A  42
VAL A  12
 CRQ  A  62 ( 3.6A)
CRQ  A  62 ( 4.2A)
None
None
 1.10A 1uyuA-2c9jA:
undetectable		 1uyuA-2c9jA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 1uyuA-2ct8A:
undetectable		 1uyuA-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 267
THR A  11
THR A 345
VAL A 305
 None
 0.91A 1uyuA-2dpnA:
undetectable		 1uyuA-2dpnA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02686
(Glu-tRNAGln) 		4 THR B  37
LEU B  42
THR C  84
ASP B 140
 None
 0.83A 1uyuA-2f2aB:
undetectable		 1uyuA-2f2aB:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl5 IMMUNOGLOBULIN IGG1
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H  20
THR H  49
VAL H  63
ASP H  86
 None
 1.17A 1uyuA-2fl5H:
undetectable		 1uyuA-2fl5H:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		4 PHE A  77
TYR A  78
VAL A 148
VAL A 197
 None
 1.18A 1uyuA-2h0aA:
undetectable		 1uyuA-2h0aA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		4 THR A 111
VAL A  69
THR A  35
VAL A  37
 None
 1.00A 1uyuA-2hngA:
undetectable		 1uyuA-2hngA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		4 TYR A  17
THR A 111
THR A  35
VAL A  37
 None
 0.77A 1uyuA-2hngA:
undetectable		 1uyuA-2hngA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		4 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.10A 1uyuA-2iueA:
undetectable		 1uyuA-2iueA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.97A 1uyuA-2k8dA:
undetectable		 1uyuA-2k8dA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
LEU A 244
THR A 252
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.4A)
None
 1.27A 1uyuA-2m56A:
69.9		 1uyuA-2m56A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		8 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
THR A 252
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.33A 1uyuA-2m56A:
69.9		 1uyuA-2m56A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		4 PHE A 192
THR A 135
LEU A 231
VAL A 207
 None
 1.15A 1uyuA-2m83A:
undetectable		 1uyuA-2m83A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		4 THR A 135
LEU A 231
VAL A 207
VAL A 161
 None
 1.05A 1uyuA-2m83A:
undetectable		 1uyuA-2m83A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  27
THR H  98
LEU H   4
VAL H  72
 None
 1.03A 1uyuA-2oz4H:
undetectable		 1uyuA-2oz4H:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2
HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09454
(Vps23_core)
PF07200
(Mod_r)
PF09452
(Mvb12) 		4 PHE D  71
TYR D  75
LEU C  58
VAL A 232
 None
 1.18A 1uyuA-2p22D:
undetectable		 1uyuA-2p22D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		4 LEU A  34
VAL A  36
THR A  55
VAL A 135
 None
 1.09A 1uyuA-2pbkA:
undetectable		 1uyuA-2pbkA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe4 HYALURONIDASE-1

(Homo sapiens) 		PF01630
(Glyco_hydro_56) 		4 TYR A 339
LEU A 303
THR A  34
VAL A  55
 None
 1.19A 1uyuA-2pe4A:
undetectable		 1uyuA-2pe4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A   6
ASP A 147
 None
 1.04A 1uyuA-2r8rA:
undetectable		 1uyuA-2r8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A 121
ASP A 147
 None
 0.96A 1uyuA-2r8rA:
undetectable		 1uyuA-2r8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 LEU A 263
VAL A 266
THR A 271
VAL A 315
 HEM  A 450 ( 4.5A)
VGJ  A1429 ( 4.8A)
HEM  A 450 (-3.1A)
HEM  A 450 (-4.5A)
 0.55A 1uyuA-2wm4A:
42.0		 1uyuA-2wm4A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 1uyuA-2wsmA:
undetectable		 1uyuA-2wsmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 LEU A  68
VAL A  65
VAL A  91
ASP A 404
 None
 1.10A 1uyuA-2xvgA:
undetectable		 1uyuA-2xvgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 TYR A  80
THR A 118
LEU A 127
VAL A 139
 FON  A 461 (-4.1A)
None
None
None
 1.16A 1uyuA-3gehA:
undetectable		 1uyuA-3gehA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A 379
VAL A 339
THR A 317
ASP A 350
 None
 0.96A 1uyuA-3glqA:
undetectable		 1uyuA-3glqA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A 517
VAL A 475
THR A 453
ASP A 486
 None
 0.90A 1uyuA-3gvpA:
undetectable		 1uyuA-3gvpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkr INTEGRASE

(Bovine
immunodeficiency
virus) 		PF00665
(rve) 		4 LEU A 113
THR A  79
VAL A 151
ASP A  64
 None
 0.97A 1uyuA-3kkrA:
undetectable		 1uyuA-3kkrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 226
THR A 232
VAL A 262
ASP A 253
 None
 1.16A 1uyuA-3lm5A:
undetectable		 1uyuA-3lm5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 TYR A 635
LEU A 539
VAL A 535
THR A 562
 None
 1.03A 1uyuA-3m62A:
undetectable		 1uyuA-3m62A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 151
LEU A 163
VAL A 199
VAL A 170
 None
 0.99A 1uyuA-3m9vA:
undetectable		 1uyuA-3m9vA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		4 TYR A 135
LEU A 143
VAL A 119
THR A 189
 None
 0.90A 1uyuA-3ocjA:
undetectable		 1uyuA-3ocjA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on6 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		4 TYR A 368
THR A 413
VAL A 375
VAL A 349
 None
PEG  A 495 ( 4.8A)
None
None
 1.12A 1uyuA-3on6A:
undetectable		 1uyuA-3on6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 117
VAL A  40
THR A   6
ASP A  77
 None
 0.92A 1uyuA-3ozyA:
undetectable		 1uyuA-3ozyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		4 TYR A 374
THR A 419
VAL A 381
VAL A 355
 None
 1.10A 1uyuA-3p2cA:
undetectable		 1uyuA-3p2cA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2f AHL SYNTHASE

(Burkholderia
glumae) 		PF00765
(Autoind_synth) 		4 PHE A 105
LEU A 189
THR A   3
VAL A  55
 None
 1.11A 1uyuA-3p2fA:
undetectable		 1uyuA-3p2fA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 0.99A 1uyuA-3pvlA:
undetectable		 1uyuA-3pvlA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz6 HPCH/HPAI ALDOLASE

(Desulfitobacterium
hafniense) 		PF03328
(HpcH_HpaI) 		4 TYR A  30
THR A  16
THR A 241
ASP A 235
 None
 1.13A 1uyuA-3qz6A:
undetectable		 1uyuA-3qz6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.86A 1uyuA-3rimA:
undetectable		 1uyuA-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 THR A  71
LEU A 152
VAL A 150
VAL A 103
 None
 0.98A 1uyuA-3skvA:
undetectable		 1uyuA-3skvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.89A 1uyuA-3t6gA:
undetectable		 1uyuA-3t6gA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 TYR A 289
THR A 293
LEU A  15
ASP A 300
 None
 1.13A 1uyuA-3t6sA:
undetectable		 1uyuA-3t6sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 TYR A 289
THR A 293
LEU A  15
THR A 144
 None
 1.12A 1uyuA-3t6sA:
undetectable		 1uyuA-3t6sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 THR A 181
LEU A 175
VAL A 171
VAL A 161
 None
 0.97A 1uyuA-3tosA:
undetectable		 1uyuA-3tosA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
LEU A 104
THR A  53
ASP A  76
 2AN  A 201 (-4.8A)
None
2AN  A 201 ( 4.0A)
2AN  A 201 (-3.9A)
 1.03A 1uyuA-3wbgA:
undetectable		 1uyuA-3wbgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A)
PF01115
(F_actin_cap_B) 		4 TYR A 243
LEU A 202
VAL B 189
THR A 206
 None
 1.14A 1uyuA-4akrA:
undetectable		 1uyuA-4akrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 LEU A 851
VAL A 846
THR A 894
ASP A 870
 None
 0.98A 1uyuA-4bocA:
undetectable		 1uyuA-4bocA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 THR A  86
LEU A 211
VAL A  35
ASP A  28
 None
 1.02A 1uyuA-4c0rA:
undetectable		 1uyuA-4c0rA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 THR A  86
LEU A 211
VAL A 207
ASP A  28
 None
 1.14A 1uyuA-4c0rA:
undetectable		 1uyuA-4c0rA:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
LEU A 252
THR A 260
VAL A 303
ASP A 305
 None
HEM  A1418 (-4.0A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.49A 1uyuA-4c9mA:
59.1		 1uyuA-4c9mA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A  98
LEU A 252
THR A 260
VAL A 404
 None
HEM  A1418 (-4.0A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.5A)
 1.13A 1uyuA-4c9mA:
59.1		 1uyuA-4c9mA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
THR A 103
LEU A 252
THR A 260
VAL A 303
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
 0.44A 1uyuA-4c9mA:
59.1		 1uyuA-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 THR A 593
LEU A 508
VAL A 511
THR A 515
 None
 0.98A 1uyuA-4czwA:
undetectable		 1uyuA-4czwA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PHE A  87
LEU A 250
THR A 258
VAL A 301
 None
HEM  A 501 (-4.3A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
 0.71A 1uyuA-4dxyA:
52.3		 1uyuA-4dxyA:
46.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 THR A 101
LEU A 250
THR A 258
VAL A 301
 HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
 0.93A 1uyuA-4dxyA:
52.3		 1uyuA-4dxyA:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		4 THR A   8
LEU A   6
VAL A  38
VAL A  94
 None
 1.16A 1uyuA-4eogA:
undetectable		 1uyuA-4eogA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A 153
LEU A  21
VAL A  17
VAL A 164
 None
 1.11A 1uyuA-4ol9A:
undetectable		 1uyuA-4ol9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 THR A 225
LEU A 309
VAL A 307
VAL A 125
 None
 1.15A 1uyuA-4pprA:
undetectable		 1uyuA-4pprA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.19A 1uyuA-4q4aB:
undetectable		 1uyuA-4q4aB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		4 THR A 140
THR A 119
VAL A  56
ASP A  50
 GOL  A 402 ( 4.6A)
None
None
GOL  A 402 (-4.3A)
 1.15A 1uyuA-4q7aA:
undetectable		 1uyuA-4q7aA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 PHE A 473
THR A 503
LEU A 449
VAL A 445
 None
 1.19A 1uyuA-4q7lA:
undetectable		 1uyuA-4q7lA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 THR A 116
LEU A 144
VAL A 134
ASP A  60
 None
 1.20A 1uyuA-4r85A:
undetectable		 1uyuA-4r85A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 PHE B1070
THR B1033
LEU B1125
THR B1043
 None
 1.19A 1uyuA-4tshB:
undetectable		 1uyuA-4tshB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 THR A 274
LEU A 236
THR A 337
VAL A 339
 None
 1.19A 1uyuA-4w7sA:
undetectable		 1uyuA-4w7sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		4 PHE A 291
THR A 255
LEU A 277
THR A 296
 None
 1.04A 1uyuA-4w8oA:
undetectable		 1uyuA-4w8oA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ

(Escherichia
coli) 		PF03180
(Lipoprotein_9) 		4 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.14A 1uyuA-4yahX:
undetectable		 1uyuA-4yahX:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima;
Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 LEU B 263
THR A 222
VAL A  91
ASP A  89
 None
 0.82A 1uyuA-4yryB:
undetectable		 1uyuA-4yryB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS

(Bacillus
subtilis) 		PF00067
(p450) 		4 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.70A 1uyuA-4yzrA:
42.7		 1uyuA-4yzrA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.12A 1uyuA-4z23A:
undetectable		 1uyuA-4z23A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae) 		no annotation 4 THR A 184
LEU A 142
VAL A 243
VAL A 194
 None
 0.87A 1uyuA-4z8tA:
undetectable		 1uyuA-4z8tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.02A 1uyuA-5a2rA:
undetectable		 1uyuA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2

(Human
immunodeficiency
virus 2) 		PF00516
(GP120) 		4 PHE G 482
LEU G 301
VAL G 357
VAL G 412
 None
 0.97A 1uyuA-5cayG:
undetectable		 1uyuA-5cayG:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 THR A 146
LEU A 171
VAL A 185
VAL A 104
 None
 1.16A 1uyuA-5izdA:
undetectable		 1uyuA-5izdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 THR A 384
LEU A 380
THR A 319
VAL A 336
 None
 1.14A 1uyuA-5j04A:
undetectable		 1uyuA-5j04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 TYR A 322
THR A 343
VAL A 547
VAL A 543
 None
 1.05A 1uyuA-5mz9A:
undetectable		 1uyuA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 TYR A 322
VAL A 547
THR A 573
VAL A 543
 None
 1.13A 1uyuA-5mz9A:
undetectable		 1uyuA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 PHE B 176
LEU B 187
VAL B 183
VAL B 318
 None
 1.04A 1uyuA-5sy7B:
undetectable		 1uyuA-5sy7B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj4 UNCHARACTERIZED
PROTEIN

(Borrelia
turicatae) 		no annotation 4 LEU A 168
THR A 226
VAL A 263
ASP A 260
 None
 1.17A 1uyuA-5vj4A:
undetectable		 1uyuA-5vj4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A 338
VAL A 296
THR A 274
ASP A 307
 None
 0.95A 1uyuA-5w4bA:
undetectable		 1uyuA-5w4bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtn REPLICATION
INITIATION AND
MEMBRANE ATTACHMENT
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 PHE A 211
LEU A 266
VAL A 229
VAL A 220
 None
 1.09A 1uyuA-5wtnA:
undetectable		 1uyuA-5wtnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 PHE A   7
TYR A 459
THR A 651
LEU A 435
 None
 0.94A 1uyuA-5x2gA:
undetectable		 1uyuA-5x2gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 PHE A1012
THR A 791
VAL A1128
VAL A1022
 None
 1.19A 1uyuA-5x59A:
undetectable		 1uyuA-5x59A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 4 PHE A 245
LEU A  39
VAL A  25
THR A 103
 None
 1.14A 1uyuA-5xksA:
undetectable		 1uyuA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnx BIFUNCTIONAL
(P)PPGPP
SYNTHASE/HYDROLASE
RELA

(Mycobacterium
tuberculosis) 		PF04607
(RelA_SpoT)
PF13328
(HD_4) 		4 LEU A 188
VAL A 184
VAL A  60
ASP A 145
 None
None
None
MG  A 401 (-3.7A)
 1.15A 1uyuA-5xnxA:
undetectable		 1uyuA-5xnxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuy AUTOPHAGY-RELATED
PROTEIN 13

(Homo sapiens) 		no annotation 4 PHE A  20
VAL A 173
THR A 132
VAL A  27
 None
 1.18A 1uyuA-5xuyA:
undetectable		 1uyuA-5xuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2

(Mycobacterium
marinum) 		no annotation 4 LEU A 256
VAL A 259
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 0.59A 1uyuA-6bldA:
42.3		 1uyuA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 4 PHE A 395
THR A 402
LEU A 414
VAL A 418
 None
 1.13A 1uyuA-6bvgA:
undetectable		 1uyuA-6bvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 LEU B 367
VAL B 318
THR B 296
ASP B 329
 None
 0.96A 1uyuA-6f3mB:
undetectable		 1uyuA-6f3mB:
undetectable