SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWJ_B_BAXB1723_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		3 ILE A 279
ASP A 276
PHE A 259
 None
 0.60A 1uwjB-1c8oA:
undetectable		 1uwjB-1c8oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 ILE A 180
ASP A 159
PHE A 160
 None
 0.63A 1uwjB-1clwA:
0.0		 1uwjB-1clwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 ILE A 146
ASP A 190
PHE A 187
 None
 0.44A 1uwjB-1i5pA:
1.3		 1uwjB-1i5pA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 ILE A 289
ASP A 292
PHE A 293
 None
 0.50A 1uwjB-1jyeA:
undetectable		 1uwjB-1jyeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 ILE A 251
ASP A 200
PHE A 202
 None
 0.64A 1uwjB-1k0fA:
0.0		 1uwjB-1k0fA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		3 ILE A 465
ASP A 441
PHE A 438
 None
 0.61A 1uwjB-1kzhA:
undetectable		 1uwjB-1kzhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc)
PF14671
(DSPn) 		3 ILE A 177
ASP A  88
PHE A  89
 None
 0.46A 1uwjB-1oheA:
0.0		 1uwjB-1oheA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ILE A 798
ASP A 810
PHE A 811
 None
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.57A 1uwjB-1t46A:
28.4		 1uwjB-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 ILE A 289
ASP A 292
PHE A 293
 None
 0.53A 1uwjB-1tlfA:
undetectable		 1uwjB-1tlfA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 ILE A 251
ASP A 200
PHE A 202
 None
 0.60A 1uwjB-1toaA:
undetectable		 1uwjB-1toaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		3 ILE A 139
ASP A  87
PHE A  88
 None
 0.63A 1uwjB-1un1A:
undetectable		 1uwjB-1un1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		3 ILE A  96
ASP A  44
PHE A  99
 None
 0.63A 1uwjB-1wczA:
undetectable		 1uwjB-1wczA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ILE A  88
ASP A  75
PHE A  23
 None
 0.41A 1uwjB-2b5mA:
undetectable		 1uwjB-2b5mA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		3 ILE A  51
ASP A 237
PHE A 232
 None
 0.64A 1uwjB-2bznA:
undetectable		 1uwjB-2bznA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrococcus
horikoshii) 		PF00215
(OMPdecase) 		3 ILE A 103
ASP A  80
PHE A  75
 None
 0.53A 1uwjB-2czdA:
undetectable		 1uwjB-2czdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 ILE A 448
ASP A 361
PHE A 360
 None
 0.41A 1uwjB-2g39A:
undetectable		 1uwjB-2g39A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		3 ILE A  14
ASP A  22
PHE A  23
 None
 0.52A 1uwjB-2he3A:
undetectable		 1uwjB-2he3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		3 ILE A 226
ASP A 213
PHE A 214
 None
 0.55A 1uwjB-2inrA:
undetectable		 1uwjB-2inrA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j67 TOLL LIKE RECEPTOR
10

(Homo sapiens) 		PF01582
(TIR) 		3 ILE A 638
ASP A 644
PHE A 700
 None
 0.66A 1uwjB-2j67A:
undetectable		 1uwjB-2j67A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		3 ILE A 362
ASP A 375
PHE A 372
 None
 0.62A 1uwjB-2jjqA:
undetectable		 1uwjB-2jjqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 ILE A  69
ASP A  36
PHE A  33
 None
 0.44A 1uwjB-2jssA:
undetectable		 1uwjB-2jssA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbf ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		3 ILE A 475
ASP A 310
PHE A 439
 None
 0.54A 1uwjB-2kbfA:
undetectable		 1uwjB-2kbfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhs CBP21

(Serratia
marcescens) 		PF03067
(LPMO_10) 		3 ILE A 147
ASP A 113
PHE A 112
 None
 0.63A 1uwjB-2lhsA:
undetectable		 1uwjB-2lhsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF13676
(TIR_2) 		3 ILE A  83
ASP A  89
PHE A 143
 None
 0.53A 1uwjB-2m1wA:
undetectable		 1uwjB-2m1wA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m2a FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Escherichia
coli) 		PF00254
(FKBP_C) 		3 ILE A 121
ASP A 124
PHE A 125
 None
 0.62A 1uwjB-2m2aA:
undetectable		 1uwjB-2m2aA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 ILE A 210
ASP A 207
PHE A 203
 None
 0.59A 1uwjB-2o1vA:
undetectable		 1uwjB-2o1vA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1l HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF10980
(DUF2787) 		3 ILE A  62
ASP A  79
PHE A  80
 None
 0.50A 1uwjB-2v1lA:
undetectable		 1uwjB-2v1lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		3 ILE A 225
ASP A 204
PHE A 205
 None
 0.65A 1uwjB-2v5iA:
undetectable		 1uwjB-2v5iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 ILE A 701
ASP A 720
PHE A 717
 None
 0.46A 1uwjB-2vcaA:
undetectable		 1uwjB-2vcaA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 3 ILE B 165
ASP B 168
PHE B 148
 None
 0.64A 1uwjB-2vduB:
undetectable		 1uwjB-2vduB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvq SMALL S PROTEIN

(Podospora
anserina) 		PF14479
(HeLo) 		3 ILE A 207
ASP A  46
PHE A  25
 None
 0.58A 1uwjB-2wvqA:
undetectable		 1uwjB-2wvqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		3 ILE B 764
ASP B 767
PHE B 768
 None
 0.39A 1uwjB-2xhlB:
undetectable		 1uwjB-2xhlB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 ILE A 367
ASP A 358
PHE A 359
 None
 0.61A 1uwjB-2xy9A:
undetectable		 1uwjB-2xy9A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 ILE A 345
ASP A 336
PHE A 337
 None
 0.61A 1uwjB-2xydA:
undetectable		 1uwjB-2xydA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Bacteroides
vulgatus) 		PF00891
(Methyltransf_2) 		3 ILE A 267
ASP A 324
PHE A 320
 None
 0.65A 1uwjB-3dp7A:
undetectable		 1uwjB-3dp7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		3 ILE A 310
ASP A 314
PHE A 315
 None
 0.65A 1uwjB-3ejwA:
undetectable		 1uwjB-3ejwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhn PROTEIN TRANSPORT
PROTEIN TIP20

(Saccharomyces
cerevisiae) 		PF04437
(RINT1_TIP1) 		3 ILE A 595
ASP A 620
PHE A 617
 None
 0.55A 1uwjB-3fhnA:
undetectable		 1uwjB-3fhnA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		3 ILE A 264
ASP A 292
PHE A 289
 None
 0.57A 1uwjB-3hjlA:
undetectable		 1uwjB-3hjlA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ILE A1028
ASP A1040
PHE A1041
 None
None
8ST  A2001 ( 3.7A)
 0.65A 1uwjB-3hngA:
27.9		 1uwjB-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		3 ILE A 148
ASP A 145
PHE A 140
 None
 0.66A 1uwjB-3i4iA:
undetectable		 1uwjB-3i4iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		3 ILE A 170
ASP A 197
PHE A 194
 None
 0.58A 1uwjB-3ijdA:
undetectable		 1uwjB-3ijdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ILE A 312
ASP A 305
PHE A 126
 None
 0.65A 1uwjB-3ip3A:
undetectable		 1uwjB-3ip3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv1 P22 PROTEIN

(Trypanosoma
brucei) 		PF02330
(MAM33) 		3 ILE A  75
ASP A  82
PHE A  90
 None
 0.61A 1uwjB-3jv1A:
undetectable		 1uwjB-3jv1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		3 ILE A 561
ASP A 605
PHE A 604
 None
 0.66A 1uwjB-3la6A:
undetectable		 1uwjB-3la6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		3 ILE A 262
ASP A 297
PHE A 328
 None
 0.61A 1uwjB-3lggA:
undetectable		 1uwjB-3lggA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
ovatus) 		PF00877
(NLPC_P60) 		3 ILE A 180
ASP A 245
PHE A 306
 GOL  A 332 ( 4.8A)
None
None
 0.64A 1uwjB-3npfA:
undetectable		 1uwjB-3npfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 ILE A 278
ASP A 196
PHE A 193
 None
 0.67A 1uwjB-3p1vA:
undetectable		 1uwjB-3p1vA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 ILE A  44
ASP A 108
PHE A 105
 None
 0.56A 1uwjB-3sp1A:
undetectable		 1uwjB-3sp1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 ILE A1120
ASP A1213
PHE A1214
 None
 0.58A 1uwjB-3topA:
undetectable		 1uwjB-3topA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		3 ILE A 596
ASP A 590
PHE A 462
 None
 0.66A 1uwjB-3up3A:
undetectable		 1uwjB-3up3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ILE A  42
ASP A 317
PHE A 353
 None
 0.64A 1uwjB-3uszA:
undetectable		 1uwjB-3uszA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ILE A 181
ASP A 247
PHE A 248
 GOL  A 706 ( 4.4A)
None
None
 0.56A 1uwjB-3ve2A:
undetectable		 1uwjB-3ve2A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		3 ILE A 362
ASP A 356
PHE A 326
 None
ANP  A1401 (-3.4A)
None
 0.45A 1uwjB-3zlbA:
undetectable		 1uwjB-3zlbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA

(Salmonella
enterica) 		PF03193
(RsgA_GTPase) 		3 ILE V 219
ASP V 271
PHE V 266
 None
 0.59A 1uwjB-4a2iV:
undetectable		 1uwjB-4a2iV:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ILE A 164
ASP A 223
PHE A 220
 None
 0.53A 1uwjB-4bf5A:
undetectable		 1uwjB-4bf5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE

(Trypanosoma
brucei) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 ILE A   7
ASP A 235
PHE A 258
 None
None
GOL  A1298 ( 4.0A)
 0.64A 1uwjB-4cjxA:
undetectable		 1uwjB-4cjxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckk DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV) 		3 ILE A 229
ASP A 216
PHE A 217
 None
 0.58A 1uwjB-4ckkA:
0.2		 1uwjB-4ckkA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		3 ILE A 144
ASP A  52
PHE A  53
 None
 0.63A 1uwjB-4d47A:
undetectable		 1uwjB-4d47A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		3 ILE A 230
ASP A 217
PHE A 218
 None
 0.53A 1uwjB-4ddqA:
undetectable		 1uwjB-4ddqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 ILE A 278
ASP A 196
PHE A 193
 None
 0.63A 1uwjB-4df9A:
undetectable		 1uwjB-4df9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		3 ILE A 360
ASP A 354
PHE A 324
 None
 0.57A 1uwjB-4dg5A:
undetectable		 1uwjB-4dg5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		3 ILE A 165
ASP A 172
PHE A 145
 None
 0.63A 1uwjB-4euoA:
undetectable		 1uwjB-4euoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		3 ILE A1225
ASP A1212
PHE A1213
 None
 0.57A 1uwjB-4i3hA:
0.2		 1uwjB-4i3hA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		3 ILE A 139
ASP A 112
PHE A 113
 None
 0.56A 1uwjB-4i7hA:
undetectable		 1uwjB-4i7hA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		3 ILE A 268
ASP A 254
PHE A 251
 None
 0.61A 1uwjB-4mlaA:
undetectable		 1uwjB-4mlaA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 ILE D 885
ASP D 951
PHE D 947
 MLY  D 884 ( 4.0A)
None
MLY  D 946 ( 4.7A)
 0.59A 1uwjB-4ngeD:
1.8		 1uwjB-4ngeD:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofs PROBABLE LIPOAMIDE
ACYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00198
(2-oxoacid_dh) 		3 ILE A  66
ASP A 209
PHE A 206
 None
 0.66A 1uwjB-4ofsA:
undetectable		 1uwjB-4ofsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 ILE A 276
ASP A 283
PHE A 284
 None
 0.59A 1uwjB-4pdxA:
undetectable		 1uwjB-4pdxA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ILE A 709
ASP A 713
PHE A 714
 None
 0.57A 1uwjB-4pj3A:
undetectable		 1uwjB-4pj3A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 ILE B1230
ASP B1217
PHE B1218
 None
 0.52A 1uwjB-4plbB:
2.5		 1uwjB-4plbB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		3 ILE A  26
ASP A  99
PHE A 100
 None
 0.46A 1uwjB-4py9A:
undetectable		 1uwjB-4py9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ILE A 317
ASP A  47
PHE A  44
 None
 0.54A 1uwjB-4qs9A:
undetectable		 1uwjB-4qs9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1j GU4 NUCLEIC-BINDING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF01588
(tRNA_bind) 		3 ILE A 126
ASP A  10
PHE A  11
 None
 0.57A 1uwjB-4r1jA:
undetectable		 1uwjB-4r1jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr4 TYPE III
IODOTHYRONINE
DEIODINASE

(Mus musculus) 		PF00837
(T4_deiodinase) 		3 ILE A 115
ASP A 124
PHE A 125
 None
 0.59A 1uwjB-4tr4A:
undetectable		 1uwjB-4tr4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 ILE A  81
ASP A 117
PHE A 118
 None
 0.66A 1uwjB-4wzbA:
undetectable		 1uwjB-4wzbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 3 ILE A 299
ASP A 270
PHE A 271
 None
 0.60A 1uwjB-4xn3A:
undetectable		 1uwjB-4xn3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yds FLAGELLA-RELATED
PROTEIN H

(Sulfolobus
acidocaldarius) 		PF06745
(ATPase) 		3 ILE A 153
ASP A 117
PHE A  44
 None
 0.60A 1uwjB-4ydsA:
undetectable		 1uwjB-4ydsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		3 ILE A 460
ASP A 393
PHE A 389
 None
 0.59A 1uwjB-4yjiA:
undetectable		 1uwjB-4yjiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 ILE A 307
ASP A 392
PHE A 393
 None
CA  A 502 (-3.1A)
None
 0.60A 1uwjB-4ysjA:
24.3		 1uwjB-4ysjA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV) 		3 ILE A 227
ASP A 214
PHE A 215
 None
 0.59A 1uwjB-4z2eA:
2.6		 1uwjB-4z2eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 ILE A1225
ASP A1212
PHE A1213
 None
 0.57A 1uwjB-4z3oA:
undetectable		 1uwjB-4z3oA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 ILE A 511
ASP A 378
PHE A 375
 None
 0.63A 1uwjB-4zr5A:
undetectable		 1uwjB-4zr5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		3 ILE A 351
ASP A 342
PHE A 343
 None
 0.64A 1uwjB-5a2rA:
undetectable		 1uwjB-5a2rA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		3 ILE A 364
ASP A 359
PHE A 320
 None
 0.50A 1uwjB-5b48A:
undetectable		 1uwjB-5b48A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		3 ILE A 230
ASP A 217
PHE A 218
 ILE  A 230 ( 0.7A)
ASP  A 217 ( 0.5A)
PHE  A 218 ( 1.3A)
 0.57A 1uwjB-5cdnA:
1.8		 1uwjB-5cdnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ILE A  88
ASP A  75
PHE A  23
 None
 0.30A 1uwjB-5fqdA:
undetectable		 1uwjB-5fqdA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 ILE A 176
ASP A 243
PHE A 185
 None
 0.66A 1uwjB-5gmsA:
undetectable		 1uwjB-5gmsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ILE A 267
ASP A 198
PHE A 199
 None
6GA  A1015 (-3.1A)
None
 0.58A 1uwjB-5j6sA:
undetectable		 1uwjB-5j6sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npt TELOMERASE REVERSE
TRANSCRIPTASE

(Ogataea
polymorpha) 		no annotation 3 ILE A 115
ASP A   4
PHE A   3
 None
 0.61A 1uwjB-5nptA:
undetectable		 1uwjB-5nptA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 3 ILE A 453
ASP A 418
PHE A 438
 None
 0.66A 1uwjB-5obuA:
undetectable		 1uwjB-5obuA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		3 ILE A 101
ASP A 147
PHE A 119
 None
 0.59A 1uwjB-5sy4A:
undetectable		 1uwjB-5sy4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 ILE A  40
ASP A 273
PHE A 295
 None
 0.64A 1uwjB-5tc4A:
undetectable		 1uwjB-5tc4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubj ALPHA-L-ARABINOFURAN
OSIDASE AXHA-2

(Aspergillus
nidulans) 		PF03664
(Glyco_hydro_62) 		3 ILE A 186
ASP A 287
PHE A 105
 None
 0.61A 1uwjB-5ubjA:
undetectable		 1uwjB-5ubjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11

(Homo sapiens) 		no annotation 3 ILE X 217
ASP X 211
PHE X 232
 None
 0.66A 1uwjB-5vfrX:
undetectable		 1uwjB-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		3 ILE A  69
ASP A 169
PHE A 170
 None
None
FAD  A 701 (-4.5A)
 0.57A 1uwjB-5wgxA:
undetectable		 1uwjB-5wgxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		3 ILE A 139
ASP A  50
PHE A  51
 None
 0.39A 1uwjB-5xw5A:
undetectable		 1uwjB-5xw5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqq MEMBRANE-ANCHORED
LIPID-BINDING
PROTEIN YSP2

(Saccharomyces
cerevisiae) 		no annotation 3 ILE A1136
ASP A1140
PHE A1144
 None
 0.64A 1uwjB-5yqqA:
undetectable		 1uwjB-5yqqA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 ILE A 161
ASP A 382
PHE A 381
 None
 0.63A 1uwjB-6bljA:
1.4		 1uwjB-6bljA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 3 ILE J 175
ASP J 137
PHE J 140
 None
 0.58A 1uwjB-6fhsJ:
undetectable		 1uwjB-6fhsJ:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 3 ILE A 535
ASP A 504
PHE A 502
 None
 0.57A 1uwjB-6fnwA:
undetectable		 1uwjB-6fnwA:
16.54