SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWJ_B_BAXB1723_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
VAL A  18
ALA A  31
GLU A  51
CYH A  83
HIS A 124
 None
 0.77A 1uwjB-1h4lA:
23.3		 1uwjB-1h4lA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ILE A 201
VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.61A 1uwjB-1k9aA:
7.7		 1uwjB-1k9aA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 275
ALA A 288
GLU A 305
THR A 334
LEU A 373
HIS A 380
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
 0.66A 1uwjB-1opkA:
7.1		 1uwjB-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ILE A 211
VAL A 219
ALA A 230
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.68A 1uwjB-1py5A:
24.7		 1uwjB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
 0.51A 1uwjB-1rjbA:
7.7		 1uwjB-1rjbA:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
THR A 670
CYH A 673
LEU A 783
HIS A 790
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
 0.65A 1uwjB-1t46A:
28.4		 1uwjB-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ILE A  34
VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.86A 1uwjB-1u5qA:
7.2		 1uwjB-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
None
 0.57A 1uwjB-1zltA:
21.2		 1uwjB-1zltA:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ILE A  34
VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 (-4.2A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
None
None
None
 0.86A 1uwjB-2gcdA:
8.0		 1uwjB-2gcdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 635
VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
 0.99A 1uwjB-2henA:
7.5		 1uwjB-2henA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
HIS A 752
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
None
 0.92A 1uwjB-2henA:
7.5		 1uwjB-2henA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 ILE A 428
VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.80A 1uwjB-2j0jA:
11.6		 1uwjB-2j0jA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 428
VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.1A)
None
None
BII  A1687 ( 3.9A)
 0.86A 1uwjB-2jkmA:
10.6		 1uwjB-2jkmA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
GLU A 288
THR A 316
HIS A 362
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
 0.51A 1uwjB-2og8A:
8.0		 1uwjB-2og8A:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
THR A 663
CYH A 666
LEU A 769
HIS A 776
GLY A 795
 None
 0.57A 1uwjB-2ogvA:
26.3		 1uwjB-2ogvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 495
ALA A 515
GLU A 534
LEU A 617
HIS A 624
 None
 0.47A 1uwjB-2psqA:
7.5		 1uwjB-2psqA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
VAL B  55
ALA B  67
GLU B  85
LEU B 155
HIS B 162
 None
 1.09A 1uwjB-2qkwB:
7.1		 1uwjB-2qkwB:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.87A 1uwjB-2qluA:
6.7		 1uwjB-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 ILE A 428
ALA A 449
GLU A 463
THR A 493
LEU A 530
HIS A 537
 None
 0.82A 1uwjB-2qr7A:
20.3		 1uwjB-2qr7A:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 681
VAL A 689
ALA A 705
GLU A 724
THR A 753
LEU A 791
HIS A 798
 None
 1.05A 1uwjB-2r2pA:
7.5		 1uwjB-2r2pA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
 0.51A 1uwjB-2w4kA:
6.8		 1uwjB-2w4kA:
26.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
 0.51A 1uwjB-2xikA:
7.8		 1uwjB-2xikA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
VAL A 635
ALA A 651
THR A 699
LEU A 737
HIS A 744
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.5A)
None
None
 0.76A 1uwjB-2xyuA:
7.9		 1uwjB-2xyuA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 305
VAL A 313
ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.78A 1uwjB-2z2wA:
22.7		 1uwjB-2z2wA:
26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1010
ALA A1028
GLU A1047
LEU A1123
HIS A1130
GLY A1149
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
None
None
 0.75A 1uwjB-2z8cA:
8.2		 1uwjB-2z8cA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 None
C4F  A   1 (-3.3A)
None
None
None
 0.51A 1uwjB-3c4fA:
7.4		 1uwjB-3c4fA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 201
VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.61A 1uwjB-3d7uA:
27.7		 1uwjB-3d7uA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 639
VAL A 647
ALA A 663
GLU A 682
LEU A 749
HIS A 756
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
 0.88A 1uwjB-3dkoA:
7.8		 1uwjB-3dkoA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 841
ALA A 859
GLU A 878
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.61A 1uwjB-3hngA:
27.9		 1uwjB-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.58A 1uwjB-3kulA:
7.9		 1uwjB-3kulA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 689
ALA A 700
GLU A 715
CYH A 748
LEU A 788
HIS A 795
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
ADP  A2101 (-4.2A)
None
None
 0.59A 1uwjB-3lj0A:
7.8		 1uwjB-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 ILE A 210
VAL A 218
ALA A 229
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
 0.85A 1uwjB-3mdyA:
6.7		 1uwjB-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
None
 0.53A 1uwjB-3my0A:
9.6		 1uwjB-3my0A:
27.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A 355
VAL A 363
ALA A 373
GLU A 393
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
 SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
 0.93A 1uwjB-3omvA:
13.4		 1uwjB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A 355
VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
 SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
 0.72A 1uwjB-3omvA:
13.4		 1uwjB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ILE A 557
VAL A 565
ALA A 576
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
None
None
 0.90A 1uwjB-3ppzA:
8.0		 1uwjB-3ppzA:
39.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.85A 1uwjB-3q4tA:
24.3		 1uwjB-3q4tA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  71
ALA A  84
GLU A 115
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
None
None
 0.67A 1uwjB-3q5iA:
7.2		 1uwjB-3q5iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B 603
ALA B 616
GLU B 635
CYH B 889
HIS B 933
GLY B 952
 None
 0.75A 1uwjB-3qd2B:
21.6		 1uwjB-3qd2B:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 431
ALA A 443
THR A 489
LEU A 527
HIS A 534
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
None
None
 0.47A 1uwjB-3sxsA:
8.0		 1uwjB-3sxsA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
None
 0.46A 1uwjB-3tt0A:
7.2		 1uwjB-3tt0A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 303
ALA A 315
GLU A 334
LEU A 347
LEU A 404
HIS A 414
GLY A 433
 None
 1.13A 1uwjB-3ulzA:
6.2		 1uwjB-3ulzA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
None
None
 0.71A 1uwjB-3vidA:
26.7		 1uwjB-3vidA:
27.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
None
None
 0.66A 1uwjB-3wzdA:
7.8		 1uwjB-3wzdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1959
ALA A1978
LEU A2010
LEU A2070
HIS A2077
GLY A2101
 None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
 0.82A 1uwjB-3zbfA:
10.4		 1uwjB-3zbfA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 625
VAL A 633
ALA A 649
GLU A 668
THR A 697
LEU A 735
HIS A 742
 None
 0.96A 1uwjB-3zfxA:
7.6		 1uwjB-3zfxA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwjB-4a4lA:
6.7		 1uwjB-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
None
None
 0.65A 1uwjB-4agdA:
7.2		 1uwjB-4agdA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
VAL A  18
ALA A  31
GLU A  51
CYH A  83
HIS A 124
 D15  A 500 (-4.2A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
D15  A 500 (-4.3A)
None
 0.64A 1uwjB-4aguA:
23.9		 1uwjB-4aguA:
25.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A  97
VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
 1.01A 1uwjB-4aw5A:
7.7		 1uwjB-4aw5A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
HIS A 214
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
None
 0.87A 1uwjB-4aw5A:
7.7		 1uwjB-4aw5A:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.56A 1uwjB-4b6lA:
6.6		 1uwjB-4b6lA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  50
ALA A  63
GLU A  81
CYH A 113
LEU A 148
HIS A 155
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-3.7A)
None
None
 0.74A 1uwjB-4bc6A:
22.0		 1uwjB-4bc6A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 222
ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.47A 1uwjB-4c02A:
7.0		 1uwjB-4c02A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 653
GLU A 672
THR A 701
LEU A 757
HIS A 764
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
 0.70A 1uwjB-4ckrA:
7.8		 1uwjB-4ckrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
VAL A 575
ALA A 588
GLU A 607
LEU A 674
HIS A 681
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
 1.10A 1uwjB-4e93A:
28.7		 1uwjB-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 ILE A 327
VAL A 335
ALA A 348
GLU A 366
LEU A 431
HIS A 438
 None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
None
 0.82A 1uwjB-4fieA:
7.5		 1uwjB-4fieA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 863
ALA A 880
GLU A 898
LEU A 967
HIS A 974
GLY A 993
 None
IZA  A2001 (-3.4A)
None
None
None
None
 0.83A 1uwjB-4gl9A:
9.8		 1uwjB-4gl9A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
THR A 205
LEU A 243
HIS A 250
GLY A 269
 None
 0.54A 1uwjB-4hzsA:
10.8		 1uwjB-4hzsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.62A 1uwjB-4i6fA:
4.5		 1uwjB-4i6fA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 ALA A  66
GLU A  87
CYH A 119
LEU A 153
HIS A 160
GLY A 179
 None
 0.76A 1uwjB-4j7bA:
24.1		 1uwjB-4j7bA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
LEU A  73
CYH A  92
LEU A 127
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
 0.34A 1uwjB-4jxfA:
19.1		 1uwjB-4jxfA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
GLU A  70
CYH A 102
LEU A 137
HIS A 144
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.0A)
None
None
 1.05A 1uwjB-4lg4A:
23.5		 1uwjB-4lg4A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
None
 0.69A 1uwjB-4m69A:
7.5		 1uwjB-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  86
ALA A  99
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
None
None
 0.75A 1uwjB-4mvfA:
20.1		 1uwjB-4mvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B  38
ALA B  51
GLU B  70
LEU B 135
HIS B 142
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
 0.45A 1uwjB-4o27B:
7.5		 1uwjB-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
GLU A  85
THR A 123
CYH A 126
HIS A 171
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.54A 1uwjB-4o38A:
20.9		 1uwjB-4o38A:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 227
VAL A 235
ALA A 248
THR A 301
LEU A 338
GLY A 367
 None
 1.29A 1uwjB-4pwnA:
8.8		 1uwjB-4pwnA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 235
ALA A 248
THR A 301
LEU A 338
HIS A 347
GLY A 367
 None
 0.80A 1uwjB-4pwnA:
8.8		 1uwjB-4pwnA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.46A 1uwjB-4rt7A:
10.3		 1uwjB-4rt7A:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 0.85A 1uwjB-4ueuA:
11.5		 1uwjB-4ueuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
ALA A  72
GLU A  90
CYH A 129
LEU A 165
HIS A 174
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
None
None
 0.82A 1uwjB-4wsqA:
23.2		 1uwjB-4wsqA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 481
ALA A 501
GLU A 520
LEU A 603
HIS A 610
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
None
 0.45A 1uwjB-4xcuA:
27.2		 1uwjB-4xcuA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.45A 1uwjB-4xufA:
27.4		 1uwjB-4xufA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 VAL A 416
ALA A 428
THR A 474
LEU A 512
HIS A 519
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
 0.47A 1uwjB-4y93A:
11.5		 1uwjB-4y93A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
ALA A 488
GLU A 509
THR A 539
LEU A 577
HIS A 586
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
None
None
 0.80A 1uwjB-4yffA:
26.2		 1uwjB-4yffA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
VAL A 477
ALA A 488
GLU A 509
THR A 539
LEU A 577
 4CV  A 801 (-4.3A)
None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
None
 0.71A 1uwjB-4yffA:
26.2		 1uwjB-4yffA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 586
ALA A 597
GLU A 612
CYH A 645
LEU A 679
HIS A 686
 None
 0.66A 1uwjB-4z7gA:
5.2		 1uwjB-4z7gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
None
 0.46A 1uwjB-5a46A:
7.4		 1uwjB-5a46A:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
VAL A  30
ALA A  44
CYH A  95
LEU A 129
HIS A 136
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
None
None
 0.92A 1uwjB-5ci7A:
22.7		 1uwjB-5ci7A:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
GLU A 290
LEU A 305
THR A 325
LEU A 361
HIS A 377
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
 0.80A 1uwjB-5e8yA:
6.5		 1uwjB-5e8yA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 463
VAL A 471
ALA A 481
LEU A 514
THR A 529
TRP A 531
CYH A 532
GLY A 593
LYS A 601
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 ( 3.7A)
None
 0.98A 1uwjB-5fd2A:
35.3		 1uwjB-5fd2A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A 463
VAL A 471
ALA A 481
LEU A 514
THR A 529
TRP A 531
CYH A 532
LEU A 567
HIS A 574
GLY A 593
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
None
5XJ  A 801 ( 3.7A)
 0.58A 1uwjB-5fd2A:
35.3		 1uwjB-5fd2A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 607
ALA A 625
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.58A 1uwjB-5grnA:
7.8		 1uwjB-5grnA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
VAL A  30
ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.8A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.85A 1uwjB-5j5tA:
21.1		 1uwjB-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 396
VAL A 404
ALA A 417
GLU A 436
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 ( 4.7A)
 0.89A 1uwjB-5jznA:
7.1		 1uwjB-5jznA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE B 672
VAL B 680
ALA B 690
THR B 739
CYH B 742
LEU B 777
 6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
None
 1.07A 1uwjB-5kkrB:
10.1		 1uwjB-5kkrB:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE B 672
VAL B 680
ALA B 690
THR B 739
LEU B 777
HIS B 784
 6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
None
None
 0.87A 1uwjB-5kkrB:
10.1		 1uwjB-5kkrB:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 228
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
 0.92A 1uwjB-5ko1A:
8.6		 1uwjB-5ko1A:
26.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 639
VAL A 647
ALA A 663
THR A 711
LEU A 749
HIS A 756
 6P6  A1001 (-4.0A)
None
6P6  A1001 (-3.3A)
6P6  A1001 (-3.5A)
None
DIO  A1002 (-4.1A)
 0.62A 1uwjB-5l6oA:
8.3		 1uwjB-5l6oA:
33.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
VAL A 897
ALA A 909
GLU A 927
LEU A 997
HIS A1007
 None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
None
 0.95A 1uwjB-5lpyA:
6.5		 1uwjB-5lpyA:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 VAL A 161
ALA A 174
THR A 227
LEU A 264
HIS A 273
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
None
None
GOL  A 604 ( 4.6A)
 0.63A 1uwjB-5o2cA:
8.6		 1uwjB-5o2cA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.66A 1uwjB-5vcxA:
5.6		 1uwjB-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 218
VAL A 226
ALA A 239
GLU A 259
CYH A 292
HIS A 337
GLY A 379
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
8X7  A 501 (-3.8A)
None
None
 0.97A 1uwjB-5vdkA:
21.7		 1uwjB-5vdkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 VAL A  36
ALA A  49
GLU A  69
LEU A  82
LEU A 132
HIS A 141
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
VX6  A 402 ( 4.8A)
None
None
 0.54A 1uwjB-5wnmA:
9.1		 1uwjB-5wnmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 VAL A 899
ALA A 917
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.70A 1uwjB-5wnoA:
8.4		 1uwjB-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 6 ILE A  29
VAL A  37
ALA A  50
LEU A 102
THR A 118
HIS A 163
 None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
None
 1.04A 1uwjB-5x1tA:
22.6		 1uwjB-5x1tA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 ILE A 215
VAL A 223
ALA A 236
GLU A 253
LEU A 326
HIS A 333
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
None
 1.00A 1uwjB-5y86A:
6.3		 1uwjB-5y86A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 VAL A 889
ALA A 906
GLU A 925
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
None
 0.76A 1uwjB-6c7yA:
24.8		 1uwjB-6c7yA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 VAL A 205
ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.64A 1uwjB-6cz4A:
10.7		 1uwjB-6cz4A:
13.82