SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWJ_B_BAXB1723
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 10VAL A 18ALA A 31GLU A 51CYH A 83HIS A 124 | None | 0.77A | 1uwjB-1h4lA:23.3 | 1uwjB-1h4lA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 7 | ILE A 201VAL A 209ALA A 220GLU A 236THR A 266LEU A 305HIS A 312 | None | 0.61A | 1uwjB-1k9aA:7.7 | 1uwjB-1k9aA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | VAL A 275ALA A 288GLU A 305THR A 334LEU A 373HIS A 380 | P16 A 2 (-4.5A)P16 A 2 (-3.4A)P16 A 2 (-4.2A)P16 A 2 (-3.7A)NoneNone | 0.66A | 1uwjB-1opkA:7.1 | 1uwjB-1opkA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1py5 | TGF-BETA RECEPTORTYPE I (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 7 | ILE A 211VAL A 219ALA A 230GLU A 245LEU A 260LEU A 316HIS A 331 | PY1 A 700 (-3.6A)PY1 A 700 ( 4.7A)PY1 A 700 (-3.5A)PY1 A 700 ( 4.9A)PY1 A 700 (-4.2A)NoneNone | 0.68A | 1uwjB-1py5A:24.7 | 1uwjB-1py5A:29.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 624ALA A 642GLU A 661CYH A 694LEU A 802HIS A 809 | None | 0.51A | 1uwjB-1rjbA:7.7 | 1uwjB-1rjbA:26.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 603ALA A 621GLU A 640THR A 670CYH A 673LEU A 783HIS A 790 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.5A)NoneSTI A 3 (-4.5A) | 0.65A | 1uwjB-1t46A:28.4 | 1uwjB-1t46A:30.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5q | SERINE/THREONINEPROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 8 | ILE A 34VAL A 42ALA A 55GLU A 76CYH A 108LEU A 142HIS A 149GLY A 168 | None | 0.86A | 1uwjB-1u5qA:7.2 | 1uwjB-1u5qA:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 23ALA A 36GLU A 55CYH A 87LEU A 121HIS A 128 | HYM A 400 (-4.3A)HYM A 400 (-3.5A)NoneHYM A 400 (-4.2A)NoneNone | 0.57A | 1uwjB-1zltA:21.2 | 1uwjB-1zltA:25.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gcd | SERINE/THREONINE-PROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 8 | ILE A 34VAL A 42ALA A 55GLU A 76CYH A 108LEU A 142HIS A 149GLY A 168 | STU A 400 (-4.2A)STU A 400 ( 4.8A)STU A 400 (-3.2A)NoneSTU A 400 (-4.0A)NoneNoneNone | 0.86A | 1uwjB-2gcdA:8.0 | 1uwjB-2gcdA:31.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hen | EPHRIN TYPE-BRECEPTOR 2 (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | ILE A 635VAL A 643ALA A 659GLU A 678THR A 707LEU A 745 | ADP A 400 (-4.9A)ADP A 400 ( 4.4A)ADP A 400 (-3.2A)ADP A 400 ( 4.9A)ADP A 400 (-4.7A)None | 0.99A | 1uwjB-2henA:7.5 | 1uwjB-2henA:32.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hen | EPHRIN TYPE-BRECEPTOR 2 (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | VAL A 643ALA A 659GLU A 678THR A 707LEU A 745HIS A 752 | ADP A 400 ( 4.4A)ADP A 400 (-3.2A)ADP A 400 ( 4.9A)ADP A 400 (-4.7A)NoneNone | 0.92A | 1uwjB-2henA:7.5 | 1uwjB-2henA:32.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 8 | ILE A 428VAL A 436ALA A 452GLU A 471CYH A 502LEU A 537HIS A 544GLY A 563 | 4ST A1687 (-4.2A)4ST A1687 ( 4.8A)4ST A1687 (-3.3A)4ST A1687 ( 4.6A)4ST A1687 (-4.1A)NoneNoneNone | 0.80A | 1uwjB-2j0jA:11.6 | 1uwjB-2j0jA:17.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2jkm | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF07714(Pkinase_Tyr) | 8 | ILE A 428VAL A 436ALA A 452GLU A 471CYH A 502LEU A 537HIS A 544GLY A 563 | BII A1687 (-3.8A)BII A1687 ( 4.7A)BII A1687 (-3.5A)NoneBII A1687 (-4.1A)NoneNoneBII A1687 ( 3.9A) | 0.86A | 1uwjB-2jkmA:10.6 | 1uwjB-2jkmA:30.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 259ALA A 271GLU A 288THR A 316HIS A 362 | None1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.3A)None | 0.51A | 1uwjB-2og8A:8.0 | 1uwjB-2og8A:33.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | VAL A 596ALA A 614GLU A 633THR A 663CYH A 666LEU A 769HIS A 776GLY A 795 | None | 0.57A | 1uwjB-2ogvA:26.3 | 1uwjB-2ogvA:27.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 495ALA A 515GLU A 534LEU A 617HIS A 624 | None | 0.47A | 1uwjB-2psqA:7.5 | 1uwjB-2psqA:25.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkw | PROTEIN KINASE (Solanumpimpinellifolium) |
PF07714(Pkinase_Tyr) | 6 | ILE B 47VAL B 55ALA B 67GLU B 85LEU B 155HIS B 162 | None | 1.09A | 1uwjB-2qkwB:7.1 | 1uwjB-2qkwB:27.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 7 | VAL A 204ALA A 215GLU A 230LEU A 245THR A 265LEU A 301HIS A 319 | ADE A 488 ( 4.9A)ADE A 488 (-3.2A)NoneADE A 488 ( 4.5A)ADE A 488 (-4.3A)NoneNone | 0.87A | 1uwjB-2qluA:6.7 | 1uwjB-2qluA:25.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qr7 | RIBOSOMAL PROTEIN S6KINASE ALPHA-3 (Mus musculus) |
PF00069(Pkinase) | 6 | ILE A 428ALA A 449GLU A 463THR A 493LEU A 530HIS A 537 | None | 0.82A | 1uwjB-2qr7A:20.3 | 1uwjB-2qr7A:24.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | ILE A 681VAL A 689ALA A 705GLU A 724THR A 753LEU A 791HIS A 798 | None | 1.05A | 1uwjB-2r2pA:7.5 | 1uwjB-2r2pA:32.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4k | DEATH-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 27ALA A 40GLU A 64LEU A 130HIS A 137 | ADP A1303 (-4.0A)ADP A1303 (-3.5A)ADP A1303 ( 4.8A)NoneNone | 0.51A | 1uwjB-2w4kA:6.8 | 1uwjB-2w4kA:26.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 34ALA A 47GLU A 66LEU A 131HIS A 138 | J60 A1294 ( 4.9A)J60 A1294 (-3.3A)NoneNoneNone | 0.51A | 1uwjB-2xikA:7.8 | 1uwjB-2xikA:30.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | ILE A 627VAL A 635ALA A 651THR A 699LEU A 737HIS A 744 | NoneQ9G A1898 ( 4.7A)Q9G A1898 (-3.2A)Q9G A1898 (-3.5A)NoneNone | 0.76A | 1uwjB-2xyuA:7.9 | 1uwjB-2xyuA:33.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2w | WEE1-LIKE PROTEINKINASE (Homo sapiens) |
PF00069(Pkinase) | 7 | ILE A 305VAL A 313ALA A 326GLU A 346CYH A 379HIS A 424GLY A 462 | 770 A 901 (-3.8A)770 A 901 ( 4.7A)770 A 901 (-3.5A)770 A 901 (-3.9A)770 A 901 (-3.9A)NoneNone | 0.78A | 1uwjB-2z2wA:22.7 | 1uwjB-2z2wA:26.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2z8c | INSULIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A1010ALA A1028GLU A1047LEU A1123HIS A1130GLY A1149 | S91 A 1 ( 4.9A)S91 A 1 (-3.2A)NoneNoneNoneNone | 0.75A | 1uwjB-2z8cA:8.2 | 1uwjB-2z8cA:32.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 492ALA A 512GLU A 531LEU A 614HIS A 621 | NoneC4F A 1 (-3.3A)NoneNoneNone | 0.51A | 1uwjB-3c4fA:7.4 | 1uwjB-3c4fA:30.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ILE A 201VAL A 209ALA A 220GLU A 236THR A 266LEU A 305HIS A 312 | None | 0.61A | 1uwjB-3d7uA:27.7 | 1uwjB-3d7uA:31.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dko | EPHRIN TYPE-ARECEPTOR 7 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 6 | ILE A 639VAL A 647ALA A 663GLU A 682LEU A 749HIS A 756 | IHZ A1001 ( 4.8A)IHZ A1001 ( 4.4A)IHZ A1001 (-3.3A)IHZ A1001 (-3.8A)NoneIHZ A1001 ( 4.9A) | 0.88A | 1uwjB-3dkoA:7.8 | 1uwjB-3dkoA:31.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 841ALA A 859GLU A 878CYH A 912LEU A1013HIS A1020 | 8ST A2001 ( 4.6A)8ST A2001 ( 3.8A)8ST A2001 (-3.7A)8ST A2001 (-3.8A)8ST A2001 (-4.6A)8ST A2001 ( 4.8A) | 0.61A | 1uwjB-3hngA:27.9 | 1uwjB-3hngA:26.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 6 | VAL A 649ALA A 665GLU A 684THR A 713LEU A 751HIS A 758 | None | 0.58A | 1uwjB-3kulA:7.9 | 1uwjB-3kulA:29.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lj0 | SERINE/THREONINE-PROTEINKINASE/ENDORIBONUCLEASE IRE1 (Saccharomycescerevisiae) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A) | 6 | VAL A 689ALA A 700GLU A 715CYH A 748LEU A 788HIS A 795 | ADP A2101 (-4.5A)ADP A2101 (-3.5A)NoneADP A2101 (-4.2A)NoneNone | 0.59A | 1uwjB-3lj0A:7.8 | 1uwjB-3lj0A:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 8 | ILE A 210VAL A 218ALA A 229GLU A 244LEU A 259THR A 279LEU A 315HIS A 330 | LDN A 1 (-4.1A)LDN A 1 ( 4.8A)LDN A 1 (-3.6A)NoneNoneLDN A 1 (-3.8A)NoneNone | 0.85A | 1uwjB-3mdyA:6.7 | 1uwjB-3mdyA:29.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 216ALA A 227LEU A 257THR A 277LEU A 313HIS A 328 | LDN A 600 (-4.5A)LDN A 600 (-3.2A)NoneLDN A 600 (-4.0A)NoneNone | 0.53A | 1uwjB-3my0A:9.6 | 1uwjB-3my0A:27.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ILE A 355VAL A 363ALA A 373GLU A 393LEU A 406THR A 421TRP A 423CYH A 424LEU A 459GLY A 485 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNone | 0.93A | 1uwjB-3omvA:13.4 | 1uwjB-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ILE A 355VAL A 363ALA A 373LEU A 406THR A 421TRP A 423CYH A 424LEU A 459HIS A 466GLY A 485 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNoneNone | 0.72A | 1uwjB-3omvA:13.4 | 1uwjB-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 7 | ILE A 557VAL A 565ALA A 576GLU A 596THR A 625LEU A 665HIS A 674 | STU A 1 (-4.1A)STU A 1 (-4.9A)STU A 1 (-3.3A)NoneSTU A 1 (-4.1A)NoneNone | 0.90A | 1uwjB-3ppzA:8.0 | 1uwjB-3ppzA:39.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 7 | VAL A 206ALA A 217GLU A 232LEU A 247THR A 267LEU A 303HIS A 320 | TAK A 2 ( 4.9A)TAK A 2 (-3.5A)TAK A 2 ( 4.9A)NoneTAK A 2 (-3.5A)NoneNone | 0.85A | 1uwjB-3q4tA:24.3 | 1uwjB-3q4tA:29.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5i | PROTEIN KINASE (Plasmodiumberghei) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | VAL A 71ALA A 84GLU A 115THR A 144LEU A 181HIS A 188 | ANP A1634 (-4.1A)ANP A1634 (-3.6A)NoneANP A1634 (-4.6A)NoneNone | 0.67A | 1uwjB-3q5iA:7.2 | 1uwjB-3q5iA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd2 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 6 | VAL B 603ALA B 616GLU B 635CYH B 889HIS B 933GLY B 952 | None | 0.75A | 1uwjB-3qd2B:21.6 | 1uwjB-3qd2B:25.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMICTYROSINE-PROTEINKINASE BMX (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 431ALA A 443THR A 489LEU A 527HIS A 534 | PP2 A 1 (-4.5A)PP2 A 1 (-3.2A)PP2 A 1 (-3.3A)NoneNone | 0.47A | 1uwjB-3sxsA:8.0 | 1uwjB-3sxsA:31.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 492ALA A 512GLU A 531LEU A 614HIS A 621 | 07J A 1 (-4.0A)07J A 1 (-3.5A)07J A 1 (-3.8A)NoneNone | 0.46A | 1uwjB-3tt0A:7.2 | 1uwjB-3tt0A:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulz | BRASSINOSTEROIDINSENSITIVE1-ASSOCIATEDRECEPTOR KINASE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 7 | VAL A 303ALA A 315GLU A 334LEU A 347LEU A 404HIS A 414GLY A 433 | None | 1.13A | 1uwjB-3ulzA:6.2 | 1uwjB-3ulzA:28.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 848ALA A 866GLU A 885CYH A 919LEU A1019HIS A1026 | 4TT A2001 ( 4.5A)4TT A2001 (-3.5A)None4TT A2001 (-4.3A)NoneNone | 0.71A | 1uwjB-3vidA:26.7 | 1uwjB-3vidA:27.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 848ALA A 866GLU A 885CYH A 919LEU A1019HIS A1026 | LEV A1201 ( 4.9A)LEV A1201 (-3.5A)LEV A1201 (-3.7A)LEV A1201 (-4.1A)NoneNone | 0.66A | 1uwjB-3wzdA:7.8 | 1uwjB-3wzdA:30.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A1959ALA A1978LEU A2010LEU A2070HIS A2077GLY A2101 | NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)NoneNoneVGH A3000 (-3.5A) | 0.82A | 1uwjB-3zbfA:10.4 | 1uwjB-3zbfA:30.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zfx | EPHRIN TYPE-BRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ILE A 625VAL A 633ALA A 649GLU A 668THR A 697LEU A 735HIS A 742 | None | 0.96A | 1uwjB-3zfxA:7.6 | 1uwjB-3zfxA:32.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4l | SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 80GLU A 101CYH A 133LEU A 167HIS A 174GLY A 193 | 939 A1331 (-3.5A)None939 A1331 (-4.0A)NoneNoneNone | 0.71A | 1uwjB-4a4lA:6.7 | 1uwjB-4a4lA:27.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 848ALA A 866GLU A 885CYH A 919LEU A1019HIS A1026 | NoneB49 A2000 (-3.5A)NoneB49 A2000 (-4.2A)NoneNone | 0.65A | 1uwjB-4agdA:7.2 | 1uwjB-4agdA:29.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agu | CYCLIN-DEPENDENTKINASE-LIKE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 10VAL A 18ALA A 31GLU A 51CYH A 83HIS A 124 | D15 A 500 (-4.2A)D15 A 500 (-4.6A)D15 A 500 (-3.4A)NoneD15 A 500 (-4.3A)None | 0.64A | 1uwjB-4aguA:23.9 | 1uwjB-4aguA:25.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aw5 | EPHRIN TYPE-BRECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 97VAL A 105ALA A 121GLU A 140THR A 169LEU A 207 | 30K A1365 (-4.5A)30K A1365 ( 4.6A)30K A1365 (-3.2A)None30K A1365 (-3.8A)None | 1.01A | 1uwjB-4aw5A:7.7 | 1uwjB-4aw5A:32.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aw5 | EPHRIN TYPE-BRECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 105ALA A 121GLU A 140THR A 169LEU A 207HIS A 214 | 30K A1365 ( 4.6A)30K A1365 (-3.2A)None30K A1365 (-3.8A)NoneNone | 0.87A | 1uwjB-4aw5A:7.7 | 1uwjB-4aw5A:32.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b6l | SERINE/THREONINE-PROTEIN KINASE PLK3 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 89GLU A 110CYH A 142LEU A 176HIS A 183GLY A 202 | 9ZP A1333 (-3.5A)None9ZP A1333 (-4.1A)NoneNone9ZP A1333 ( 4.4A) | 0.56A | 1uwjB-4b6lA:6.6 | 1uwjB-4b6lA:27.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc6 | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 50ALA A 63GLU A 81CYH A 113LEU A 148HIS A 155 | XZN A1317 ( 4.7A)XZN A1317 (-3.5A)XZN A1317 (-3.9A)XZN A1317 (-3.7A)NoneNone | 0.74A | 1uwjB-4bc6A:22.0 | 1uwjB-4bc6A:28.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 6 | VAL A 222ALA A 233LEU A 263THR A 283LEU A 319HIS A 334 | TAK A1507 (-4.7A)TAK A1507 (-3.3A)FLC A1503 ( 4.5A)TAK A1507 (-3.6A)NoneNone | 0.47A | 1uwjB-4c02A:7.0 | 1uwjB-4c02A:27.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 624ALA A 653GLU A 672THR A 701LEU A 757HIS A 764 | DI1 A1000 (-4.8A)DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A)DI1 A1000 (-4.4A)DI1 A1000 (-3.8A) | 0.70A | 1uwjB-4ckrA:7.8 | 1uwjB-4ckrA:29.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e93 | TYROSINE-PROTEINKINASE FES/FPS (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 6 | ILE A 567VAL A 575ALA A 588GLU A 607LEU A 674HIS A 681 | GUI A 901 (-4.0A)GUI A 901 (-4.5A)GUI A 901 (-3.4A)NoneNoneNone | 1.10A | 1uwjB-4e93A:28.7 | 1uwjB-4e93A:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fie | SERINE/THREONINE-PROTEIN KINASE PAK 4 (Homo sapiens) |
PF00069(Pkinase)PF00786(PBD) | 6 | ILE A 327VAL A 335ALA A 348GLU A 366LEU A 431HIS A 438 | NoneANP A1001 (-4.7A)ANP A1001 (-3.6A)ANP A1001 (-3.6A)NoneNone | 0.82A | 1uwjB-4fieA:7.5 | 1uwjB-4fieA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl9 | TYROSINE-PROTEINKINASE (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | VAL A 863ALA A 880GLU A 898LEU A 967HIS A 974GLY A 993 | NoneIZA A2001 (-3.4A)NoneNoneNoneNone | 0.83A | 1uwjB-4gl9A:9.8 | 1uwjB-4gl9A:29.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzs | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14604(SH3_9) | 6 | VAL A 140ALA A 156THR A 205LEU A 243HIS A 250GLY A 269 | None | 0.54A | 1uwjB-4hzsA:10.8 | 1uwjB-4hzsA:29.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6f | SERINE/THREONINE-PROTEIN KINASE PLK2 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 109GLU A 130CYH A 162LEU A 196HIS A 203GLY A 222 | 1C7 A 401 (-3.2A)None1C7 A 401 (-4.1A)NoneNoneNone | 0.62A | 1uwjB-4i6fA:4.5 | 1uwjB-4i6fA:26.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j7b | POLO-LIKE KINASE (Danio rerio) |
PF00069(Pkinase) | 6 | ALA A 66GLU A 87CYH A 119LEU A 153HIS A 160GLY A 179 | None | 0.76A | 1uwjB-4j7bA:24.1 | 1uwjB-4j7bA:27.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxf | SERINE/THREONINE-PROTEIN KINASE PLK4 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 26ALA A 39LEU A 73CYH A 92LEU A 127 | 631 A 301 (-4.6A)631 A 301 (-3.3A)None631 A 301 (-4.5A)None | 0.34A | 1uwjB-4jxfA:19.1 | 1uwjB-4jxfA:27.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 41ALA A 54GLU A 70CYH A 102LEU A 137HIS A 144 | GOL A 404 (-4.5A)GOL A 404 ( 3.1A)NoneGOL A 403 (-4.0A)NoneNone | 1.05A | 1uwjB-4lg4A:23.5 | 1uwjB-4lg4A:27.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m69 | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 6 | VAL A 36ALA A 49LEU A 74THR A 95LEU A 132HIS A 141 | ANP A 401 (-4.5A)ANP A 401 (-3.1A)NoneANP A 401 (-3.8A)NoneNone | 0.69A | 1uwjB-4m69A:7.5 | 1uwjB-4m69A:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mvf | CALCIUM-DEPENDENTPROTEIN KINASE 2 (Plasmodiumfalciparum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | VAL A 86ALA A 99GLU A 117CYH A 149LEU A 183HIS A 190 | STU A 601 (-4.8A)STU A 601 (-3.3A)NoneSTU A 601 (-4.2A)NoneNone | 0.75A | 1uwjB-4mvfA:20.1 | 1uwjB-4mvfA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL B 38ALA B 51GLU B 70LEU B 135HIS B 142 | ADP B 500 (-4.5A)ADP B 500 (-3.3A)NoneNoneNone | 0.45A | 1uwjB-4o27B:7.5 | 1uwjB-4o27B:28.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 54ALA A 67GLU A 85THR A 123CYH A 126HIS A 171 | NoneSIN A 401 ( 3.7A)NoneNoneSIN A 401 (-4.3A)None | 0.54A | 1uwjB-4o38A:20.9 | 1uwjB-4o38A:25.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4pwn | SERINE/THREONINE-PROTEIN KINASE WNK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 227VAL A 235ALA A 248THR A 301LEU A 338GLY A 367 | None | 1.29A | 1uwjB-4pwnA:8.8 | 1uwjB-4pwnA:33.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4pwn | SERINE/THREONINE-PROTEIN KINASE WNK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 235ALA A 248THR A 301LEU A 338HIS A 347GLY A 367 | None | 0.80A | 1uwjB-4pwnA:8.8 | 1uwjB-4pwnA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 624ALA A 642GLU A 661CYH A 694LEU A 802HIS A 809 | NoneP30 A1001 (-3.4A)P30 A1001 (-3.6A)NoneNoneP30 A1001 ( 4.3A) | 0.46A | 1uwjB-4rt7A:10.3 | 1uwjB-4rt7A:24.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 6 | VAL A 22ALA A 35GLU A 52THR A 81LEU A 120HIS A 127 | ACP A1264 (-4.7A)ACP A1264 (-2.9A)NoneACP A1264 (-4.5A)NoneNone | 0.85A | 1uwjB-4ueuA:11.5 | 1uwjB-4ueuA:36.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 60ALA A 72GLU A 90CYH A 129LEU A 165HIS A 174 | KSA A 405 ( 4.9A)KSA A 405 (-3.2A)NoneKSA A 405 (-4.5A)NoneNone | 0.82A | 1uwjB-4wsqA:23.2 | 1uwjB-4wsqA:26.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 481ALA A 501GLU A 520LEU A 603HIS A 610 | 40M A1002 ( 4.5A)40M A1002 ( 4.1A)40M A1002 (-3.7A)NoneNone | 0.45A | 1uwjB-4xcuA:27.2 | 1uwjB-4xcuA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 624ALA A 642GLU A 661CYH A 694LEU A 802HIS A 809 | P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 (-4.2A)NoneP30 A1001 (-4.4A) | 0.45A | 1uwjB-4xufA:27.4 | 1uwjB-4xufA:28.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 5 | VAL A 416ALA A 428THR A 474LEU A 512HIS A 519 | 746 A 702 ( 4.3A)746 A 702 (-2.4A)746 A 702 (-3.7A)NoneNone | 0.47A | 1uwjB-4y93A:11.5 | 1uwjB-4y93A:23.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yff | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 469ALA A 488GLU A 509THR A 539LEU A 577HIS A 586 | 4CV A 801 (-4.3A)4CV A 801 (-3.5A)None4CV A 801 (-2.8A)NoneNone | 0.80A | 1uwjB-4yffA:26.2 | 1uwjB-4yffA:31.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yff | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 469VAL A 477ALA A 488GLU A 509THR A 539LEU A 577 | 4CV A 801 (-4.3A)None4CV A 801 (-3.5A)None4CV A 801 (-2.8A)None | 0.71A | 1uwjB-4yffA:26.2 | 1uwjB-4yffA:31.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7g | SERINE/THREONINE-PROTEINKINASE/ENDORIBONUCLEASE IRE1 (Homo sapiens) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A) | 6 | VAL A 586ALA A 597GLU A 612CYH A 645LEU A 679HIS A 686 | None | 0.66A | 1uwjB-4z7gA:5.2 | 1uwjB-4z7gA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 492ALA A 512GLU A 531LEU A 614HIS A 621 | 38O A1769 (-4.5A)38O A1769 (-3.6A)EDO A1766 (-4.1A)NoneNone | 0.46A | 1uwjB-5a46A:7.4 | 1uwjB-5a46A:25.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ci7 | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 22VAL A 30ALA A 44CYH A 95LEU A 129HIS A 136 | 51W A 401 (-3.9A)51W A 401 ( 4.3A)51W A 401 (-3.4A)51W A 401 (-3.9A)NoneNone | 0.92A | 1uwjB-5ci7A:22.7 | 1uwjB-5ci7A:31.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8y | TGF-BETA RECEPTORTYPE-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 258ALA A 275GLU A 290LEU A 305THR A 325LEU A 361HIS A 377 | STU A 601 (-4.0A)STU A 601 (-3.1A)STU A 601 ( 3.8A)STU A 601 ( 3.8A)STU A 601 ( 3.7A)NoneNone | 0.80A | 1uwjB-5e8yA:6.5 | 1uwjB-5e8yA:27.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fd2 | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | ILE A 463VAL A 471ALA A 481LEU A 514THR A 529TRP A 531CYH A 532GLY A 593LYS A 601 | 5XJ A 801 ( 4.7A)5XJ A 801 (-4.6A)5XJ A 801 (-3.1A)5XJ A 801 (-4.5A)5XJ A 801 (-3.4A)5XJ A 801 (-4.4A)5XJ A 801 (-4.6A)5XJ A 801 ( 3.7A)None | 0.98A | 1uwjB-5fd2A:35.3 | 1uwjB-5fd2A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fd2 | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ILE A 463VAL A 471ALA A 481LEU A 514THR A 529TRP A 531CYH A 532LEU A 567HIS A 574GLY A 593 | 5XJ A 801 ( 4.7A)5XJ A 801 (-4.6A)5XJ A 801 (-3.1A)5XJ A 801 (-4.5A)5XJ A 801 (-3.4A)5XJ A 801 (-4.4A)5XJ A 801 (-4.6A)NoneNone5XJ A 801 ( 3.7A) | 0.58A | 1uwjB-5fd2A:35.3 | 1uwjB-5fd2A:99.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 607ALA A 625GLU A 644THR A 674CYH A 677LEU A 809HIS A 816 | 748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 (-3.3A)748 A1001 (-3.2A)748 A1001 (-4.5A)748 A1001 ( 4.6A)748 A1001 (-3.8A) | 0.58A | 1uwjB-5grnA:7.8 | 1uwjB-5grnA:28.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 7 | ILE A 22VAL A 30ALA A 43GLU A 61CYH A 93LEU A 127HIS A 134 | 6G2 A 901 (-3.8A)6G2 A 901 ( 4.9A)6G2 A 901 (-3.2A)NoneTPO A 145 (-4.1A)NoneNone | 0.85A | 1uwjB-5j5tA:21.1 | 1uwjB-5j5tA:26.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzn | SERINE/THREONINE-PROTEIN KINASE DCLK1 (Homo sapiens) |
PF00069(Pkinase) | 7 | ILE A 396VAL A 404ALA A 417GLU A 436LEU A 502HIS A 509GLY A 532 | GUI A 701 (-4.1A)GUI A 701 (-4.4A)GUI A 701 ( 3.9A)NoneNoneNoneGUI A 701 ( 4.7A) | 0.89A | 1uwjB-5jznA:7.1 | 1uwjB-5jznA:27.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kkr | KINASE SUPPRESSOR OFRAS 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE B 672VAL B 680ALA B 690THR B 739CYH B 742LEU B 777 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)None | 1.07A | 1uwjB-5kkrB:10.1 | 1uwjB-5kkrB:34.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kkr | KINASE SUPPRESSOR OFRAS 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE B 672VAL B 680ALA B 690THR B 739LEU B 777HIS B 784 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)NoneNone | 0.87A | 1uwjB-5kkrB:10.1 | 1uwjB-5kkrB:34.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ko1 | MIXED LINEAGE KINASEDOMAIN-LIKE PROTEIN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 228GLU A 250LEU A 263CYH A 286LEU A 320HIS A 329 | 6UY A 501 (-3.4A)6UY A 501 (-4.3A)None6UY A 501 (-4.3A)NoneNone | 0.92A | 1uwjB-5ko1A:8.6 | 1uwjB-5ko1A:26.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l6o | EPHRIN TYPE-BRECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 639VAL A 647ALA A 663THR A 711LEU A 749HIS A 756 | 6P6 A1001 (-4.0A)None6P6 A1001 (-3.3A)6P6 A1001 (-3.5A)NoneDIO A1002 (-4.1A) | 0.62A | 1uwjB-5l6oA:8.3 | 1uwjB-5l6oA:33.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lpy | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 6 | ILE A 889VAL A 897ALA A 909GLU A 927LEU A 997HIS A1007 | NoneATP A1200 ( 4.5A)ATP A1200 (-3.5A)NoneNoneNone | 0.95A | 1uwjB-5lpyA:6.5 | 1uwjB-5lpyA:30.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o2c | SERINE/THREONINE-PROTEIN KINASE WNK3 (Homo sapiens) |
PF00069(Pkinase)PF12202(OSR1_C) | 6 | VAL A 161ALA A 174THR A 227LEU A 264HIS A 273GLY A 293 | NoneGOL A 604 ( 3.8A)GOL A 604 (-3.9A)NoneNoneGOL A 604 ( 4.6A) | 0.63A | 1uwjB-5o2cA:8.6 | 1uwjB-5o2cA:26.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vcx | MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 124ALA A 137GLU A 157THR A 187CYH A 190LEU A 224HIS A 231GLY A 250 | H8H A 401 (-4.7A)H8H A 401 (-3.3A)NoneH8H A 401 (-3.5A)H8H A 401 (-4.3A)NoneNoneNone | 0.66A | 1uwjB-5vcxA:5.6 | 1uwjB-5vcxA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vdk | WEE1-LIKE PROTEINKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 7 | ILE A 218VAL A 226ALA A 239GLU A 259CYH A 292HIS A 337GLY A 379 | 8X7 A 501 ( 4.0A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.8A)8X7 A 501 (-3.8A)NoneNone | 0.97A | 1uwjB-5vdkA:21.7 | 1uwjB-5vdkA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wnm | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 4 (Mus musculus) |
no annotation | 6 | VAL A 36ALA A 49GLU A 69LEU A 82LEU A 132HIS A 141 | VX6 A 402 (-4.6A)VX6 A 402 (-3.2A)VX6 A 402 (-4.4A)VX6 A 402 ( 4.8A)NoneNone | 0.54A | 1uwjB-5wnmA:9.1 | 1uwjB-5wnmA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wno | RECEPTORTYROSINE-PROTEINKINASE LET-23 (Caenorhabditiselegans) |
no annotation | 6 | VAL A 899ALA A 917LEU A 947THR A 963LEU A1001HIS A1008 | ANP A1201 (-4.4A)ANP A1201 (-3.3A)ANP A1201 (-4.7A)ANP A1201 (-3.9A)NoneNone | 0.70A | 1uwjB-5wnoA:8.4 | 1uwjB-5wnoA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1t | PPKA-294 (Serratia sp.FS14) |
no annotation | 6 | ILE A 29VAL A 37ALA A 50LEU A 102THR A 118HIS A 163 | NoneADP A 401 ( 4.5A)ADP A 401 (-3.4A)NoneADP A 401 (-4.1A)None | 1.04A | 1uwjB-5x1tA:22.6 | 1uwjB-5x1tA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y86 | DUAL SPECIFICITYTYROSINE-PHOSPHORYLATION-REGULATEDKINASE 3 (Homo sapiens) |
no annotation | 6 | ILE A 215VAL A 223ALA A 236GLU A 253LEU A 326HIS A 333 | NoneHRM A 601 ( 4.9A)HRM A 601 (-3.5A)HRM A 601 ( 4.6A)NoneNone | 1.00A | 1uwjB-5y86A:6.3 | 1uwjB-5y86A:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7y | TYROSINE-PROTEINKINASE JAK1 (Homo sapiens) |
no annotation | 6 | VAL A 889ALA A 906GLU A 925LEU A 994HIS A1001GLY A1020 | ADP A1201 (-4.3A)ADP A1201 (-3.4A)NoneNoneNoneNone | 0.76A | 1uwjB-6c7yA:24.8 | 1uwjB-6c7yA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cz4 | PROTEIN-TYROSINEKINASE 6 (Homo sapiens) |
no annotation | 7 | VAL A 205ALA A 217LEU A 248THR A 264LEU A 303HIS A 310GLY A 329 | FKY A9001 ( 4.6A)FKY A9001 (-3.3A)FKY A9001 (-4.2A)FKY A9001 (-3.0A)FKY A9001 (-4.4A)FKY A9001 (-3.9A)FKY A9001 (-3.4A) | 0.64A | 1uwjB-6cz4A:10.7 | 1uwjB-6cz4A:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8o | ICE INHIBITOR (Cowpox virus) |
PF00079(Serpin) | 3 | ILE A 279ASP A 276PHE A 259 | None | 0.60A | 1uwjB-1c8oA:undetectable | 1uwjB-1c8oA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1clw | TAILSPIKE PROTEIN (Salmonellavirus P22) |
PF09251(PhageP22-tail) | 3 | ILE A 180ASP A 159PHE A 160 | None | 0.63A | 1uwjB-1clwA:0.0 | 1uwjB-1clwA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5p | PESTICIDIAL CRYSTALPROTEIN CRY2AA (Bacillusthuringiensis) |
PF03944(Endotoxin_C)PF03945(Endotoxin_N)PF09131(Endotoxin_mid) | 3 | ILE A 146ASP A 190PHE A 187 | None | 0.44A | 1uwjB-1i5pA:1.3 | 1uwjB-1i5pA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jye | LACTOSE OPERONREPRESSOR (Escherichiacoli) |
PF13377(Peripla_BP_3) | 3 | ILE A 289ASP A 292PHE A 293 | None | 0.50A | 1uwjB-1jyeA:undetectable | 1uwjB-1jyeA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0f | PERIPLASMICZINC-BINDING PROTEINTROA (Treponemapallidum) |
PF01297(ZnuA) | 3 | ILE A 251ASP A 200PHE A 202 | None | 0.64A | 1uwjB-1k0fA:0.0 | 1uwjB-1k0fA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kzh | PHOSPHOFRUCTOKINASE (Borreliellaburgdorferi) |
PF00365(PFK) | 3 | ILE A 465ASP A 441PHE A 438 | None | 0.61A | 1uwjB-1kzhA:undetectable | 1uwjB-1kzhA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ohe | CDC14B2 PHOSPHATASE (Homo sapiens) |
PF00782(DSPc)PF14671(DSPn) | 3 | ILE A 177ASP A 88PHE A 89 | None | 0.46A | 1uwjB-1oheA:0.0 | 1uwjB-1oheA:21.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A 798ASP A 810PHE A 811 | NoneSTI A 3 (-3.9A)STI A 3 (-3.6A) | 0.57A | 1uwjB-1t46A:28.4 | 1uwjB-1t46A:30.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlf | LAC REPRESSOR (Escherichiacoli) |
PF13377(Peripla_BP_3) | 3 | ILE A 289ASP A 292PHE A 293 | None | 0.53A | 1uwjB-1tlfA:undetectable | 1uwjB-1tlfA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1toa | PROTEIN (PERIPLASMICBINDING PROTEINTROA) (Treponemapallidum) |
PF01297(ZnuA) | 3 | ILE A 251ASP A 200PHE A 202 | None | 0.60A | 1uwjB-1toaA:undetectable | 1uwjB-1toaA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1un1 | XYLOGLUCANENDOTRANSGLYCOSYLASE (Populus tremula) |
PF00722(Glyco_hydro_16)PF06955(XET_C) | 3 | ILE A 139ASP A 87PHE A 88 | None | 0.63A | 1uwjB-1un1A:undetectable | 1uwjB-1un1A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcz | GLUTAMYLENDOPEPTIDASE (Staphylococcusaureus) |
PF13365(Trypsin_2) | 3 | ILE A 96ASP A 44PHE A 99 | None | 0.63A | 1uwjB-1wczA:undetectable | 1uwjB-1wczA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5m | DAMAGE-SPECIFIC DNABINDING PROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 3 | ILE A 88ASP A 75PHE A 23 | None | 0.41A | 1uwjB-2b5mA:undetectable | 1uwjB-2b5mA:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzn | GMP REDUCTASE 2 (Homo sapiens) |
PF00478(IMPDH) | 3 | ILE A 51ASP A 237PHE A 232 | None | 0.64A | 1uwjB-2bznA:undetectable | 1uwjB-2bznA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2czd | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Pyrococcushorikoshii) |
PF00215(OMPdecase) | 3 | ILE A 103ASP A 80PHE A 75 | None | 0.53A | 1uwjB-2czdA:undetectable | 1uwjB-2czdA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g39 | ACETYL-COA HYDROLASE (Pseudomonasaeruginosa) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 3 | ILE A 448ASP A 361PHE A 360 | None | 0.41A | 1uwjB-2g39A:undetectable | 1uwjB-2g39A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2he3 | GLUTATHIONEPEROXIDASE 2 (Homo sapiens) |
PF00255(GSHPx) | 3 | ILE A 14ASP A 22PHE A 23 | None | 0.52A | 1uwjB-2he3A:undetectable | 1uwjB-2he3A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inr | DNA TOPOISOMERASE 4SUBUNIT A (Staphylococcusaureus) |
PF00521(DNA_topoisoIV) | 3 | ILE A 226ASP A 213PHE A 214 | None | 0.55A | 1uwjB-2inrA:undetectable | 1uwjB-2inrA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j67 | TOLL LIKE RECEPTOR10 (Homo sapiens) |
PF01582(TIR) | 3 | ILE A 638ASP A 644PHE A 700 | None | 0.66A | 1uwjB-2j67A:undetectable | 1uwjB-2j67A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjq | UNCHARACTERIZED RNAMETHYLTRANSFERASEPYRAB10780 (Pyrococcusabyssi) |
PF05958(tRNA_U5-meth_tr) | 3 | ILE A 362ASP A 375PHE A 372 | None | 0.62A | 1uwjB-2jjqA:undetectable | 1uwjB-2jjqA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jss | CHIMERA OF HISTONEH2B.1 AND HISTONEH2A.Z (Saccharomycescerevisiae) |
PF00125(Histone)PF16211(Histone_H2A_C) | 3 | ILE A 69ASP A 36PHE A 33 | None | 0.44A | 1uwjB-2jssA:undetectable | 1uwjB-2jssA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kbf | ATP-DEPENDENT RNAHELICASE DBP5 (Saccharomycescerevisiae) |
PF00271(Helicase_C) | 3 | ILE A 475ASP A 310PHE A 439 | None | 0.54A | 1uwjB-2kbfA:undetectable | 1uwjB-2kbfA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lhs | CBP21 (Serratiamarcescens) |
PF03067(LPMO_10) | 3 | ILE A 147ASP A 113PHE A 112 | None | 0.63A | 1uwjB-2lhsA:undetectable | 1uwjB-2lhsA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m1w | TIRDOMAIN-CONTAININGADAPTER MOLECULE 2 (Homo sapiens) |
PF13676(TIR_2) | 3 | ILE A 83ASP A 89PHE A 143 | None | 0.53A | 1uwjB-2m1wA:undetectable | 1uwjB-2m1wA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m2a | FKBP-TYPE 16 KDAPEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Escherichiacoli) |
PF00254(FKBP_C) | 3 | ILE A 121ASP A 124PHE A 125 | None | 0.62A | 1uwjB-2m2aA:undetectable | 1uwjB-2m2aA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1v | ENDOPLASMIN (Canis lupus) |
PF00183(HSP90)PF02518(HATPase_c) | 3 | ILE A 210ASP A 207PHE A 203 | None | 0.59A | 1uwjB-2o1vA:undetectable | 1uwjB-2o1vA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v1l | HYPOTHETICAL PROTEIN (Vibrio cholerae) |
PF10980(DUF2787) | 3 | ILE A 62ASP A 79PHE A 80 | None | 0.50A | 1uwjB-2v1lA:undetectable | 1uwjB-2v1lA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v5i | SALMONELLATYPHIMURIUM DB7155BACTERIOPHAGE DET7TAILSPIKE (unidentifiedphage) |
PF09251(PhageP22-tail) | 3 | ILE A 225ASP A 204PHE A 205 | None | 0.65A | 1uwjB-2v5iA:undetectable | 1uwjB-2v5iA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 3 | ILE A 701ASP A 720PHE A 717 | None | 0.46A | 1uwjB-2vcaA:undetectable | 1uwjB-2vcaA:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdu | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE-ASSOCIATED WD REPEATPROTEIN TRM82 (Saccharomycescerevisiae) |
no annotation | 3 | ILE B 165ASP B 168PHE B 148 | None | 0.64A | 1uwjB-2vduB:undetectable | 1uwjB-2vduB:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wvq | SMALL S PROTEIN (Podosporaanserina) |
PF14479(HeLo) | 3 | ILE A 207ASP A 46PHE A 25 | None | 0.58A | 1uwjB-2wvqA:undetectable | 1uwjB-2wvqA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhl | BOTULINUM NEUROTOXINB HEAVY CHAIN (Clostridiumbotulinum) |
PF07952(Toxin_trans) | 3 | ILE B 764ASP B 767PHE B 768 | None | 0.39A | 1uwjB-2xhlB:undetectable | 1uwjB-2xhlB:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xy9 | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 3 | ILE A 367ASP A 358PHE A 359 | None | 0.61A | 1uwjB-2xy9A:undetectable | 1uwjB-2xy9A:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyd | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 3 | ILE A 345ASP A 336PHE A 337 | None | 0.61A | 1uwjB-2xydA:undetectable | 1uwjB-2xydA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Bacteroidesvulgatus) |
PF00891(Methyltransf_2) | 3 | ILE A 267ASP A 324PHE A 320 | None | 0.65A | 1uwjB-3dp7A:undetectable | 1uwjB-3dp7A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejw | SMLSRB (Sinorhizobiummeliloti) |
PF13407(Peripla_BP_4) | 3 | ILE A 310ASP A 314PHE A 315 | None | 0.65A | 1uwjB-3ejwA:undetectable | 1uwjB-3ejwA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhn | PROTEIN TRANSPORTPROTEIN TIP20 (Saccharomycescerevisiae) |
PF04437(RINT1_TIP1) | 3 | ILE A 595ASP A 620PHE A 617 | None | 0.55A | 1uwjB-3fhnA:undetectable | 1uwjB-3fhnA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjl | FLAGELLAR MOTORSWITCH PROTEIN FLIG (Aquifexaeolicus) |
PF01706(FliG_C)PF14841(FliG_M)PF14842(FliG_N) | 3 | ILE A 264ASP A 292PHE A 289 | None | 0.57A | 1uwjB-3hjlA:undetectable | 1uwjB-3hjlA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | ILE A1028ASP A1040PHE A1041 | NoneNone8ST A2001 ( 3.7A) | 0.65A | 1uwjB-3hngA:27.9 | 1uwjB-3hngA:26.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4i | 1,3-1,4-BETA-GLUCANASE (unculturedmurine largebowel bacteriumBAC 14) |
PF00722(Glyco_hydro_16) | 3 | ILE A 148ASP A 145PHE A 140 | None | 0.66A | 1uwjB-3i4iA:undetectable | 1uwjB-3i4iA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijd | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF02219(MTHFR) | 3 | ILE A 170ASP A 197PHE A 194 | None | 0.58A | 1uwjB-3ijdA:undetectable | 1uwjB-3ijdA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ip3 | OXIDOREDUCTASE,PUTATIVE (Thermotogamaritima) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | ILE A 312ASP A 305PHE A 126 | None | 0.65A | 1uwjB-3ip3A:undetectable | 1uwjB-3ip3A:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv1 | P22 PROTEIN (Trypanosomabrucei) |
PF02330(MAM33) | 3 | ILE A 75ASP A 82PHE A 90 | None | 0.61A | 1uwjB-3jv1A:undetectable | 1uwjB-3jv1A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la6 | TYROSINE-PROTEINKINASE WZC (Escherichiacoli) |
PF13614(AAA_31) | 3 | ILE A 561ASP A 605PHE A 604 | None | 0.66A | 1uwjB-3la6A:undetectable | 1uwjB-3la6A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgg | ADENOSINE DEAMINASECECR1 (Homo sapiens) |
PF00962(A_deaminase)PF08451(A_deaminase_N) | 3 | ILE A 262ASP A 297PHE A 328 | None | 0.61A | 1uwjB-3lggA:undetectable | 1uwjB-3lggA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3npf | PUTATIVEDIPEPTIDYL-PEPTIDASEVI (Bacteroidesovatus) |
PF00877(NLPC_P60) | 3 | ILE A 180ASP A 245PHE A 306 | GOL A 332 ( 4.8A)NoneNone | 0.64A | 1uwjB-3npfA:undetectable | 1uwjB-3npfA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p1v | METALLO-ENDOPEPTIDASE (Bacteroidesovatus) |
PF09471(Peptidase_M64)PF16217(M64_N) | 3 | ILE A 278ASP A 196PHE A 193 | None | 0.67A | 1uwjB-3p1vA:undetectable | 1uwjB-3p1vA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sp1 | CYSTEINYL-TRNASYNTHETASE (Borreliellaburgdorferi) |
PF01406(tRNA-synt_1e) | 3 | ILE A 44ASP A 108PHE A 105 | None | 0.56A | 1uwjB-3sp1A:undetectable | 1uwjB-3sp1A:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3top | MALTASE-GLUCOAMYLASE, INTESTINAL (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 3 | ILE A1120ASP A1213PHE A1214 | None | 0.58A | 1uwjB-3topA:undetectable | 1uwjB-3topA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up3 | ACEDAF-12 (Ancylostomaceylanicum) |
PF00104(Hormone_recep) | 3 | ILE A 596ASP A 590PHE A 462 | None | 0.66A | 1uwjB-3up3A:undetectable | 1uwjB-3up3A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usz | EXO-1,3/1,4-BETA-GLUCANASE (Pseudoalteromonassp. BB1) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 3 | ILE A 42ASP A 317PHE A 353 | None | 0.64A | 1uwjB-3uszA:undetectable | 1uwjB-3uszA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ve2 | TRANSFERRIN-BINDINGPROTEIN 2 (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 3 | ILE A 181ASP A 247PHE A 248 | GOL A 706 ( 4.4A)NoneNone | 0.56A | 1uwjB-3ve2A:undetectable | 1uwjB-3ve2A:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zlb | PHOSPHOGLYCERATEKINASE (Streptococcuspneumoniae) |
PF00162(PGK) | 3 | ILE A 362ASP A 356PHE A 326 | NoneANP A1401 (-3.4A)None | 0.45A | 1uwjB-3zlbA:undetectable | 1uwjB-3zlbA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2i | PUTATIVE RIBOSOMEBIOGENESIS GTPASERSGA (Salmonellaenterica) |
PF03193(RsgA_GTPase) | 3 | ILE V 219ASP V 271PHE V 266 | None | 0.59A | 1uwjB-4a2iV:undetectable | 1uwjB-4a2iV:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf5 | ALANINE RACEMASE (Aeromonashydrophila) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | ILE A 164ASP A 223PHE A 220 | None | 0.53A | 1uwjB-4bf5A:undetectable | 1uwjB-4bf5A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cjx | C-1-TETRAHYDROFOLATESYNTHASE,CYTOPLASMIC,PUTATIVE (Trypanosomabrucei) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 3 | ILE A 7ASP A 235PHE A 258 | NoneNoneGOL A1298 ( 4.0A) | 0.64A | 1uwjB-4cjxA:undetectable | 1uwjB-4cjxA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckk | DNA GYRASE SUBUNIT A (Escherichiacoli) |
PF00521(DNA_topoisoIV) | 3 | ILE A 229ASP A 216PHE A 217 | None | 0.58A | 1uwjB-4ckkA:0.2 | 1uwjB-4ckkA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d47 | LEVANSUCRASE (Erwiniaamylovora) |
PF02435(Glyco_hydro_68) | 3 | ILE A 144ASP A 52PHE A 53 | None | 0.63A | 1uwjB-4d47A:undetectable | 1uwjB-4d47A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ddq | DNA GYRASE SUBUNIT A (Bacillussubtilis) |
PF00521(DNA_topoisoIV) | 3 | ILE A 230ASP A 217PHE A 218 | None | 0.53A | 1uwjB-4ddqA:undetectable | 1uwjB-4ddqA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4df9 | PUTATIVE PEPTIDASE (Bacteroidesfragilis) |
PF09471(Peptidase_M64)PF16217(M64_N) | 3 | ILE A 278ASP A 196PHE A 193 | None | 0.63A | 1uwjB-4df9A:undetectable | 1uwjB-4df9A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dg5 | PHOSPHOGLYCERATEKINASE (Staphylococcusaureus) |
PF00162(PGK) | 3 | ILE A 360ASP A 354PHE A 324 | None | 0.57A | 1uwjB-4dg5A:undetectable | 1uwjB-4dg5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euo | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (POLYAMINE) (Agrobacteriumfabrum) |
PF13416(SBP_bac_8) | 3 | ILE A 165ASP A 172PHE A 145 | None | 0.63A | 1uwjB-4euoA:undetectable | 1uwjB-4euoA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3h | TOPOISOMERASE IVSUBUNIT B, DNATOPOISOMERASE 4SUBUNIT A CHIMERA (Streptococcuspneumoniae) |
PF00204(DNA_gyraseB)PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim)PF02518(HATPase_c) | 3 | ILE A1225ASP A1212PHE A1213 | None | 0.57A | 1uwjB-4i3hA:0.2 | 1uwjB-4i3hA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i7h | PEROXIDE STRESSSENSING REGULATOR (Streptococcuspyogenes) |
PF01475(FUR) | 3 | ILE A 139ASP A 112PHE A 113 | None | 0.56A | 1uwjB-4i7hA:undetectable | 1uwjB-4i7hA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mla | CYTOKININ OXIDASE 2 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 3 | ILE A 268ASP A 254PHE A 251 | None | 0.61A | 1uwjB-4mlaA:undetectable | 1uwjB-4mlaA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nge | PRESEQUENCEPROTEASE,MITOCHONDRIAL (Homo sapiens) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 3 | ILE D 885ASP D 951PHE D 947 | MLY D 884 ( 4.0A)NoneMLY D 946 ( 4.7A) | 0.59A | 1uwjB-4ngeD:1.8 | 1uwjB-4ngeD:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofs | PROBABLE LIPOAMIDEACYLTRANSFERASE (Thermoplasmaacidophilum) |
PF00198(2-oxoacid_dh) | 3 | ILE A 66ASP A 209PHE A 206 | None | 0.66A | 1uwjB-4ofsA:undetectable | 1uwjB-4ofsA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pdx | PUTATIVEALKYL/ARYL-SULFATASEYJCS (Escherichiacoli) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 3 | ILE A 276ASP A 283PHE A 284 | None | 0.59A | 1uwjB-4pdxA:undetectable | 1uwjB-4pdxA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj3 | INTRON-BINDINGPROTEIN AQUARIUS (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12)PF16399(Aquarius_N) | 3 | ILE A 709ASP A 713PHE A 714 | None | 0.57A | 1uwjB-4pj3A:undetectable | 1uwjB-4pj3A:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4plb | CHIMERA PROTEIN OFDNA GYRASE SUBUNITSB AND A (Staphylococcusaureus) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 3 | ILE B1230ASP B1217PHE B1218 | None | 0.52A | 1uwjB-4plbB:2.5 | 1uwjB-4plbB:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4py9 | PUTATIVEEXOPOLYPHOSPHATASE-RELATED PROTEIN (Bacteroidesfragilis) |
PF01368(DHH) | 3 | ILE A 26ASP A 99PHE A 100 | None | 0.46A | 1uwjB-4py9A:undetectable | 1uwjB-4py9A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qs9 | HEXOKINASE-1 (Arabidopsisthaliana) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 3 | ILE A 317ASP A 47PHE A 44 | None | 0.54A | 1uwjB-4qs9A:undetectable | 1uwjB-4qs9A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1j | GU4 NUCLEIC-BINDINGPROTEIN 1 (Saccharomycescerevisiae) |
PF01588(tRNA_bind) | 3 | ILE A 126ASP A 10PHE A 11 | None | 0.57A | 1uwjB-4r1jA:undetectable | 1uwjB-4r1jA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr4 | TYPE IIIIODOTHYRONINEDEIODINASE (Mus musculus) |
PF00837(T4_deiodinase) | 3 | ILE A 115ASP A 124PHE A 125 | None | 0.59A | 1uwjB-4tr4A:undetectable | 1uwjB-4tr4A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 3 | ILE A 81ASP A 117PHE A 118 | None | 0.66A | 1uwjB-4wzbA:undetectable | 1uwjB-4wzbA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xn3 | TAIL SPIKE PROTEIN (Salmonellavirus HK620) |
no annotation | 3 | ILE A 299ASP A 270PHE A 271 | None | 0.60A | 1uwjB-4xn3A:undetectable | 1uwjB-4xn3A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yds | FLAGELLA-RELATEDPROTEIN H (Sulfolobusacidocaldarius) |
PF06745(ATPase) | 3 | ILE A 153ASP A 117PHE A 44 | None | 0.60A | 1uwjB-4ydsA:undetectable | 1uwjB-4ydsA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 3 | ILE A 460ASP A 393PHE A 389 | None | 0.59A | 1uwjB-4yjiA:undetectable | 1uwjB-4yjiA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysj | CALMODULIN-LIKEDOMAIN PROTEINKINASE (Eimeria tenella) |
PF00069(Pkinase)PF13499(EF-hand_7) | 3 | ILE A 307ASP A 392PHE A 393 | None CA A 502 (-3.1A)None | 0.60A | 1uwjB-4ysjA:24.3 | 1uwjB-4ysjA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z2e | DNA GYRASE SUBUNIT A (Streptococcuspneumoniae) |
PF00521(DNA_topoisoIV) | 3 | ILE A 227ASP A 214PHE A 215 | None | 0.59A | 1uwjB-4z2eA:2.6 | 1uwjB-4z2eA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3o | DNA TOPOISOMERASE 4SUBUNITB,PARE30-PARC55FUSED TOPO IV FROMS. PNEUMONIAE (Streptococcuspneumoniae) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 3 | ILE A1225ASP A1212PHE A1213 | None | 0.57A | 1uwjB-4z3oA:undetectable | 1uwjB-4z3oA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr5 | NEPRILYSIN (Oryctolaguscuniculus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 3 | ILE A 511ASP A 378PHE A 375 | None | 0.63A | 1uwjB-4zr5A:undetectable | 1uwjB-4zr5A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2r | ANGIOTENSIN-CONVERTING ENZYME (Drosophilamelanogaster) |
PF01401(Peptidase_M2) | 3 | ILE A 351ASP A 342PHE A 343 | None | 0.64A | 1uwjB-5a2rA:undetectable | 1uwjB-5a2rA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b48 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEALPHA SUBUNIT (Sulfurisphaeratokodaii) |
PF01558(POR)PF01855(POR_N) | 3 | ILE A 364ASP A 359PHE A 320 | None | 0.50A | 1uwjB-5b48A:undetectable | 1uwjB-5b48A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cdn | DNA GYRASE SUBUNIT A (Staphylococcusaureus) |
PF00521(DNA_topoisoIV) | 3 | ILE A 230ASP A 217PHE A 218 | ILE A 230 ( 0.7A)ASP A 217 ( 0.5A)PHE A 218 ( 1.3A) | 0.57A | 1uwjB-5cdnA:1.8 | 1uwjB-5cdnA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqd | DNA DAMAGE-BINDINGPROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 3 | ILE A 88ASP A 75PHE A 23 | None | 0.30A | 1uwjB-5fqdA:undetectable | 1uwjB-5fqdA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gms | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 3 | ILE A 176ASP A 243PHE A 185 | None | 0.66A | 1uwjB-5gmsA:undetectable | 1uwjB-5gmsA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6s | ENDOPLASMICRETICULUMAMINOPEPTIDASE 2 (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 3 | ILE A 267ASP A 198PHE A 199 | None6GA A1015 (-3.1A)None | 0.58A | 1uwjB-5j6sA:undetectable | 1uwjB-5j6sA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npt | TELOMERASE REVERSETRANSCRIPTASE (Ogataeapolymorpha) |
no annotation | 3 | ILE A 115ASP A 4PHE A 3 | None | 0.61A | 1uwjB-5nptA:undetectable | 1uwjB-5nptA:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5obu | CHAPERONE PROTEINDNAK (Mycoplasmagenitalium) |
no annotation | 3 | ILE A 453ASP A 418PHE A 438 | None | 0.66A | 1uwjB-5obuA:undetectable | 1uwjB-5obuA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy4 | CHAPERONE YAJL (Escherichiacoli) |
PF01965(DJ-1_PfpI) | 3 | ILE A 101ASP A 147PHE A 119 | None | 0.59A | 1uwjB-5sy4A:undetectable | 1uwjB-5sy4A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc4 | BIFUNCTIONALMETHYLENETETRAHYDROFOLATEDEHYDROGENASE/CYCLOHYDROLASE,MITOCHONDRIAL (Homo sapiens) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 3 | ILE A 40ASP A 273PHE A 295 | None | 0.64A | 1uwjB-5tc4A:undetectable | 1uwjB-5tc4A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubj | ALPHA-L-ARABINOFURANOSIDASE AXHA-2 (Aspergillusnidulans) |
PF03664(Glyco_hydro_62) | 3 | ILE A 186ASP A 287PHE A 105 | None | 0.61A | 1uwjB-5ubjA:undetectable | 1uwjB-5ubjA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfr | 26S PROTEASOMENON-ATPASEREGULATORY SUBUNIT11 (Homo sapiens) |
no annotation | 3 | ILE X 217ASP X 211PHE X 232 | None | 0.66A | 1uwjB-5vfrX:undetectable | 1uwjB-5vfrX:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgx | FLAVIN-DEPENDENTHALOGENASE (Malbrancheaaurantiaca) |
PF04820(Trp_halogenase) | 3 | ILE A 69ASP A 169PHE A 170 | NoneNoneFAD A 701 (-4.5A) | 0.57A | 1uwjB-5wgxA:undetectable | 1uwjB-5wgxA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xw5 | TYROSINE-PROTEINPHOSPHATASE CDC14 (Saccharomycescerevisiae) |
PF00782(DSPc)PF14671(DSPn) | 3 | ILE A 139ASP A 50PHE A 51 | None | 0.39A | 1uwjB-5xw5A:undetectable | 1uwjB-5xw5A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yqq | MEMBRANE-ANCHOREDLIPID-BINDINGPROTEIN YSP2 (Saccharomycescerevisiae) |
no annotation | 3 | ILE A1136ASP A1140PHE A1144 | None | 0.64A | 1uwjB-5yqqA:undetectable | 1uwjB-5yqqA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6blj | SERINE-TRNA LIGASE (Naegleriafowleri) |
no annotation | 3 | ILE A 161ASP A 382PHE A 381 | None | 0.63A | 1uwjB-6bljA:1.4 | 1uwjB-6bljA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhs | ARP5 (Chaetomiumthermophilum) |
no annotation | 3 | ILE J 175ASP J 137PHE J 140 | None | 0.58A | 1uwjB-6fhsJ:undetectable | 1uwjB-6fhsJ:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fnw | VOLUME-REGULATEDANION CHANNELSUBUNIT LRRC8A (Mus musculus) |
no annotation | 3 | ILE A 535ASP A 504PHE A 502 | None | 0.57A | 1uwjB-6fnwA:undetectable | 1uwjB-6fnwA:16.54 |