SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWJ_B_BAXB1723

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  10
VAL A  18
ALA A  31
GLU A  51
CYH A  83
HIS A 124
None
0.77A 1uwjB-1h4lA:
23.3
1uwjB-1h4lA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ILE A 201
VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
None
0.61A 1uwjB-1k9aA:
7.7
1uwjB-1k9aA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 VAL A 275
ALA A 288
GLU A 305
THR A 334
LEU A 373
HIS A 380
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
0.66A 1uwjB-1opkA:
7.1
1uwjB-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
7 ILE A 211
VAL A 219
ALA A 230
GLU A 245
LEU A 260
LEU A 316
HIS A 331
PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
0.68A 1uwjB-1py5A:
24.7
1uwjB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
None
0.51A 1uwjB-1rjbA:
7.7
1uwjB-1rjbA:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 603
ALA A 621
GLU A 640
THR A 670
CYH A 673
LEU A 783
HIS A 790
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
0.65A 1uwjB-1t46A:
28.4
1uwjB-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
8 ILE A  34
VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
None
0.86A 1uwjB-1u5qA:
7.2
1uwjB-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  23
ALA A  36
GLU A  55
CYH A  87
LEU A 121
HIS A 128
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
None
0.57A 1uwjB-1zltA:
21.2
1uwjB-1zltA:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
8 ILE A  34
VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
STU  A 400 (-4.2A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
None
None
None
0.86A 1uwjB-2gcdA:
8.0
1uwjB-2gcdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 ILE A 635
VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
0.99A 1uwjB-2henA:
7.5
1uwjB-2henA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
HIS A 752
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
None
0.92A 1uwjB-2henA:
7.5
1uwjB-2henA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
8 ILE A 428
VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
0.80A 1uwjB-2j0jA:
11.6
1uwjB-2j0jA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF07714
(Pkinase_Tyr)
8 ILE A 428
VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.1A)
None
None
BII  A1687 ( 3.9A)
0.86A 1uwjB-2jkmA:
10.6
1uwjB-2jkmA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 259
ALA A 271
GLU A 288
THR A 316
HIS A 362
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
0.51A 1uwjB-2og8A:
8.0
1uwjB-2og8A:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 596
ALA A 614
GLU A 633
THR A 663
CYH A 666
LEU A 769
HIS A 776
GLY A 795
None
0.57A 1uwjB-2ogvA:
26.3
1uwjB-2ogvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 495
ALA A 515
GLU A 534
LEU A 617
HIS A 624
None
0.47A 1uwjB-2psqA:
7.5
1uwjB-2psqA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
6 ILE B  47
VAL B  55
ALA B  67
GLU B  85
LEU B 155
HIS B 162
None
1.09A 1uwjB-2qkwB:
7.1
1uwjB-2qkwB:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A 204
ALA A 215
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
0.87A 1uwjB-2qluA:
6.7
1uwjB-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3


(Mus musculus)
PF00069
(Pkinase)
6 ILE A 428
ALA A 449
GLU A 463
THR A 493
LEU A 530
HIS A 537
None
0.82A 1uwjB-2qr7A:
20.3
1uwjB-2qr7A:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 ILE A 681
VAL A 689
ALA A 705
GLU A 724
THR A 753
LEU A 791
HIS A 798
None
1.05A 1uwjB-2r2pA:
7.5
1uwjB-2r2pA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
0.51A 1uwjB-2w4kA:
6.8
1uwjB-2w4kA:
26.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
0.51A 1uwjB-2xikA:
7.8
1uwjB-2xikA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 ILE A 627
VAL A 635
ALA A 651
THR A 699
LEU A 737
HIS A 744
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.5A)
None
None
0.76A 1uwjB-2xyuA:
7.9
1uwjB-2xyuA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A 305
VAL A 313
ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
0.78A 1uwjB-2z2wA:
22.7
1uwjB-2z2wA:
26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A1010
ALA A1028
GLU A1047
LEU A1123
HIS A1130
GLY A1149
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
None
None
0.75A 1uwjB-2z8cA:
8.2
1uwjB-2z8cA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
None
C4F  A   1 (-3.3A)
None
None
None
0.51A 1uwjB-3c4fA:
7.4
1uwjB-3c4fA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ILE A 201
VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
None
0.61A 1uwjB-3d7uA:
27.7
1uwjB-3d7uA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 ILE A 639
VAL A 647
ALA A 663
GLU A 682
LEU A 749
HIS A 756
IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
0.88A 1uwjB-3dkoA:
7.8
1uwjB-3dkoA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 841
ALA A 859
GLU A 878
CYH A 912
LEU A1013
HIS A1020
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
0.61A 1uwjB-3hngA:
27.9
1uwjB-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 VAL A 649
ALA A 665
GLU A 684
THR A 713
LEU A 751
HIS A 758
None
0.58A 1uwjB-3kulA:
7.9
1uwjB-3kulA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
6 VAL A 689
ALA A 700
GLU A 715
CYH A 748
LEU A 788
HIS A 795
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
ADP  A2101 (-4.2A)
None
None
0.59A 1uwjB-3lj0A:
7.8
1uwjB-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
8 ILE A 210
VAL A 218
ALA A 229
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
LDN  A   1 (-4.1A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
0.85A 1uwjB-3mdyA:
6.7
1uwjB-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 216
ALA A 227
LEU A 257
THR A 277
LEU A 313
HIS A 328
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
None
0.53A 1uwjB-3my0A:
9.6
1uwjB-3my0A:
27.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 ILE A 355
VAL A 363
ALA A 373
GLU A 393
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
0.93A 1uwjB-3omvA:
13.4
1uwjB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 ILE A 355
VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
0.72A 1uwjB-3omvA:
13.4
1uwjB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
7 ILE A 557
VAL A 565
ALA A 576
GLU A 596
THR A 625
LEU A 665
HIS A 674
STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
None
None
0.90A 1uwjB-3ppzA:
8.0
1uwjB-3ppzA:
39.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A 206
ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
0.85A 1uwjB-3q4tA:
24.3
1uwjB-3q4tA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 VAL A  71
ALA A  84
GLU A 115
THR A 144
LEU A 181
HIS A 188
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
None
None
0.67A 1uwjB-3q5iA:
7.2
1uwjB-3q5iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL B 603
ALA B 616
GLU B 635
CYH B 889
HIS B 933
GLY B 952
None
0.75A 1uwjB-3qd2B:
21.6
1uwjB-3qd2B:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 431
ALA A 443
THR A 489
LEU A 527
HIS A 534
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
None
None
0.47A 1uwjB-3sxsA:
8.0
1uwjB-3sxsA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
None
0.46A 1uwjB-3tt0A:
7.2
1uwjB-3tt0A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 VAL A 303
ALA A 315
GLU A 334
LEU A 347
LEU A 404
HIS A 414
GLY A 433
None
1.13A 1uwjB-3ulzA:
6.2
1uwjB-3ulzA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
None
None
0.71A 1uwjB-3vidA:
26.7
1uwjB-3vidA:
27.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
None
None
0.66A 1uwjB-3wzdA:
7.8
1uwjB-3wzdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A1959
ALA A1978
LEU A2010
LEU A2070
HIS A2077
GLY A2101
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
0.82A 1uwjB-3zbfA:
10.4
1uwjB-3zbfA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ILE A 625
VAL A 633
ALA A 649
GLU A 668
THR A 697
LEU A 735
HIS A 742
None
0.96A 1uwjB-3zfxA:
7.6
1uwjB-3zfxA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
0.71A 1uwjB-4a4lA:
6.7
1uwjB-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
None
None
0.65A 1uwjB-4agdA:
7.2
1uwjB-4agdA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  10
VAL A  18
ALA A  31
GLU A  51
CYH A  83
HIS A 124
D15  A 500 (-4.2A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
D15  A 500 (-4.3A)
None
0.64A 1uwjB-4aguA:
23.9
1uwjB-4aguA:
25.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A  97
VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
1.01A 1uwjB-4aw5A:
7.7
1uwjB-4aw5A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
HIS A 214
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
None
0.87A 1uwjB-4aw5A:
7.7
1uwjB-4aw5A:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  89
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
0.56A 1uwjB-4b6lA:
6.6
1uwjB-4b6lA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  50
ALA A  63
GLU A  81
CYH A 113
LEU A 148
HIS A 155
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-3.7A)
None
None
0.74A 1uwjB-4bc6A:
22.0
1uwjB-4bc6A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
6 VAL A 222
ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
0.47A 1uwjB-4c02A:
7.0
1uwjB-4c02A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 624
ALA A 653
GLU A 672
THR A 701
LEU A 757
HIS A 764
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
0.70A 1uwjB-4ckrA:
7.8
1uwjB-4ckrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
6 ILE A 567
VAL A 575
ALA A 588
GLU A 607
LEU A 674
HIS A 681
GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
1.10A 1uwjB-4e93A:
28.7
1uwjB-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4


(Homo sapiens)
PF00069
(Pkinase)
PF00786
(PBD)
6 ILE A 327
VAL A 335
ALA A 348
GLU A 366
LEU A 431
HIS A 438
None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
None
0.82A 1uwjB-4fieA:
7.5
1uwjB-4fieA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 VAL A 863
ALA A 880
GLU A 898
LEU A 967
HIS A 974
GLY A 993
None
IZA  A2001 (-3.4A)
None
None
None
None
0.83A 1uwjB-4gl9A:
9.8
1uwjB-4gl9A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14604
(SH3_9)
6 VAL A 140
ALA A 156
THR A 205
LEU A 243
HIS A 250
GLY A 269
None
0.54A 1uwjB-4hzsA:
10.8
1uwjB-4hzsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A 109
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
None
None
0.62A 1uwjB-4i6fA:
4.5
1uwjB-4i6fA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio)
PF00069
(Pkinase)
6 ALA A  66
GLU A  87
CYH A 119
LEU A 153
HIS A 160
GLY A 179
None
0.76A 1uwjB-4j7bA:
24.1
1uwjB-4j7bA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  26
ALA A  39
LEU A  73
CYH A  92
LEU A 127
631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
0.34A 1uwjB-4jxfA:
19.1
1uwjB-4jxfA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  41
ALA A  54
GLU A  70
CYH A 102
LEU A 137
HIS A 144
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.0A)
None
None
1.05A 1uwjB-4lg4A:
23.5
1uwjB-4lg4A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL A  36
ALA A  49
LEU A  74
THR A  95
LEU A 132
HIS A 141
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
None
0.69A 1uwjB-4m69A:
7.5
1uwjB-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2


(Plasmodium
falciparum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 VAL A  86
ALA A  99
GLU A 117
CYH A 149
LEU A 183
HIS A 190
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
None
None
0.75A 1uwjB-4mvfA:
20.1
1uwjB-4mvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24


(Homo sapiens)
PF00069
(Pkinase)
5 VAL B  38
ALA B  51
GLU B  70
LEU B 135
HIS B 142
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
0.45A 1uwjB-4o27B:
7.5
1uwjB-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  54
ALA A  67
GLU A  85
THR A 123
CYH A 126
HIS A 171
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
0.54A 1uwjB-4o38A:
20.9
1uwjB-4o38A:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A 227
VAL A 235
ALA A 248
THR A 301
LEU A 338
GLY A 367
None
1.29A 1uwjB-4pwnA:
8.8
1uwjB-4pwnA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 235
ALA A 248
THR A 301
LEU A 338
HIS A 347
GLY A 367
None
0.80A 1uwjB-4pwnA:
8.8
1uwjB-4pwnA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
0.46A 1uwjB-4rt7A:
10.3
1uwjB-4rt7A:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 VAL A  22
ALA A  35
GLU A  52
THR A  81
LEU A 120
HIS A 127
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
0.85A 1uwjB-4ueuA:
11.5
1uwjB-4ueuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  60
ALA A  72
GLU A  90
CYH A 129
LEU A 165
HIS A 174
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
None
None
0.82A 1uwjB-4wsqA:
23.2
1uwjB-4wsqA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 481
ALA A 501
GLU A 520
LEU A 603
HIS A 610
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
None
0.45A 1uwjB-4xcuA:
27.2
1uwjB-4xcuA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
0.45A 1uwjB-4xufA:
27.4
1uwjB-4xufA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
5 VAL A 416
ALA A 428
THR A 474
LEU A 512
HIS A 519
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
0.47A 1uwjB-4y93A:
11.5
1uwjB-4y93A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 469
ALA A 488
GLU A 509
THR A 539
LEU A 577
HIS A 586
4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
None
None
0.80A 1uwjB-4yffA:
26.2
1uwjB-4yffA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 469
VAL A 477
ALA A 488
GLU A 509
THR A 539
LEU A 577
4CV  A 801 (-4.3A)
None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
None
0.71A 1uwjB-4yffA:
26.2
1uwjB-4yffA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Homo sapiens)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
6 VAL A 586
ALA A 597
GLU A 612
CYH A 645
LEU A 679
HIS A 686
None
0.66A 1uwjB-4z7gA:
5.2
1uwjB-4z7gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
None
0.46A 1uwjB-5a46A:
7.4
1uwjB-5a46A:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  22
VAL A  30
ALA A  44
CYH A  95
LEU A 129
HIS A 136
51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
None
None
0.92A 1uwjB-5ci7A:
22.7
1uwjB-5ci7A:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 258
ALA A 275
GLU A 290
LEU A 305
THR A 325
LEU A 361
HIS A 377
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
0.80A 1uwjB-5e8yA:
6.5
1uwjB-5e8yA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ILE A 463
VAL A 471
ALA A 481
LEU A 514
THR A 529
TRP A 531
CYH A 532
GLY A 593
LYS A 601
5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 ( 3.7A)
None
0.98A 1uwjB-5fd2A:
35.3
1uwjB-5fd2A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 ILE A 463
VAL A 471
ALA A 481
LEU A 514
THR A 529
TRP A 531
CYH A 532
LEU A 567
HIS A 574
GLY A 593
5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
None
5XJ  A 801 ( 3.7A)
0.58A 1uwjB-5fd2A:
35.3
1uwjB-5fd2A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 607
ALA A 625
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
0.58A 1uwjB-5grnA:
7.8
1uwjB-5grnA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A  22
VAL A  30
ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
6G2  A 901 (-3.8A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
0.85A 1uwjB-5j5tA:
21.1
1uwjB-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A 396
VAL A 404
ALA A 417
GLU A 436
LEU A 502
HIS A 509
GLY A 532
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 ( 4.7A)
0.89A 1uwjB-5jznA:
7.1
1uwjB-5jznA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE B 672
VAL B 680
ALA B 690
THR B 739
CYH B 742
LEU B 777
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
None
1.07A 1uwjB-5kkrB:
10.1
1uwjB-5kkrB:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE B 672
VAL B 680
ALA B 690
THR B 739
LEU B 777
HIS B 784
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
None
None
0.87A 1uwjB-5kkrB:
10.1
1uwjB-5kkrB:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 228
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
0.92A 1uwjB-5ko1A:
8.6
1uwjB-5ko1A:
26.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 639
VAL A 647
ALA A 663
THR A 711
LEU A 749
HIS A 756
6P6  A1001 (-4.0A)
None
6P6  A1001 (-3.3A)
6P6  A1001 (-3.5A)
None
DIO  A1002 (-4.1A)
0.62A 1uwjB-5l6oA:
8.3
1uwjB-5l6oA:
33.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
6 ILE A 889
VAL A 897
ALA A 909
GLU A 927
LEU A 997
HIS A1007
None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
None
0.95A 1uwjB-5lpyA:
6.5
1uwjB-5lpyA:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3


(Homo sapiens)
PF00069
(Pkinase)
PF12202
(OSR1_C)
6 VAL A 161
ALA A 174
THR A 227
LEU A 264
HIS A 273
GLY A 293
None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
None
None
GOL  A 604 ( 4.6A)
0.63A 1uwjB-5o2cA:
8.6
1uwjB-5o2cA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
0.66A 1uwjB-5vcxA:
5.6
1uwjB-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A 218
VAL A 226
ALA A 239
GLU A 259
CYH A 292
HIS A 337
GLY A 379
8X7  A 501 ( 4.0A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
8X7  A 501 (-3.8A)
None
None
0.97A 1uwjB-5vdkA:
21.7
1uwjB-5vdkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4


(Mus musculus)
no annotation 6 VAL A  36
ALA A  49
GLU A  69
LEU A  82
LEU A 132
HIS A 141
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
VX6  A 402 ( 4.8A)
None
None
0.54A 1uwjB-5wnmA:
9.1
1uwjB-5wnmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 6 VAL A 899
ALA A 917
LEU A 947
THR A 963
LEU A1001
HIS A1008
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
0.70A 1uwjB-5wnoA:
8.4
1uwjB-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14)
no annotation 6 ILE A  29
VAL A  37
ALA A  50
LEU A 102
THR A 118
HIS A 163
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
None
1.04A 1uwjB-5x1tA:
22.6
1uwjB-5x1tA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3


(Homo sapiens)
no annotation 6 ILE A 215
VAL A 223
ALA A 236
GLU A 253
LEU A 326
HIS A 333
None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
None
1.00A 1uwjB-5y86A:
6.3
1uwjB-5y86A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1


(Homo sapiens)
no annotation 6 VAL A 889
ALA A 906
GLU A 925
LEU A 994
HIS A1001
GLY A1020
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
None
0.76A 1uwjB-6c7yA:
24.8
1uwjB-6c7yA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 7 VAL A 205
ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
0.64A 1uwjB-6cz4A:
10.7
1uwjB-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus)
PF00079
(Serpin)
3 ILE A 279
ASP A 276
PHE A 259
None
0.60A 1uwjB-1c8oA:
undetectable
1uwjB-1c8oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22)
PF09251
(PhageP22-tail)
3 ILE A 180
ASP A 159
PHE A 160
None
0.63A 1uwjB-1clwA:
0.0
1uwjB-1clwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA


(Bacillus
thuringiensis)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid)
3 ILE A 146
ASP A 190
PHE A 187
None
0.44A 1uwjB-1i5pA:
1.3
1uwjB-1i5pA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR


(Escherichia
coli)
PF13377
(Peripla_BP_3)
3 ILE A 289
ASP A 292
PHE A 293
None
0.50A 1uwjB-1jyeA:
undetectable
1uwjB-1jyeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA


(Treponema
pallidum)
PF01297
(ZnuA)
3 ILE A 251
ASP A 200
PHE A 202
None
0.64A 1uwjB-1k0fA:
0.0
1uwjB-1k0fA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi)
PF00365
(PFK)
3 ILE A 465
ASP A 441
PHE A 438
None
0.61A 1uwjB-1kzhA:
undetectable
1uwjB-1kzhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens)
PF00782
(DSPc)
PF14671
(DSPn)
3 ILE A 177
ASP A  88
PHE A  89
None
0.46A 1uwjB-1oheA:
0.0
1uwjB-1oheA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A 798
ASP A 810
PHE A 811
None
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.57A 1uwjB-1t46A:
28.4
1uwjB-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli)
PF13377
(Peripla_BP_3)
3 ILE A 289
ASP A 292
PHE A 293
None
0.53A 1uwjB-1tlfA:
undetectable
1uwjB-1tlfA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)


(Treponema
pallidum)
PF01297
(ZnuA)
3 ILE A 251
ASP A 200
PHE A 202
None
0.60A 1uwjB-1toaA:
undetectable
1uwjB-1toaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE


(Populus tremula)
PF00722
(Glyco_hydro_16)
PF06955
(XET_C)
3 ILE A 139
ASP A  87
PHE A  88
None
0.63A 1uwjB-1un1A:
undetectable
1uwjB-1un1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE


(Staphylococcus
aureus)
PF13365
(Trypsin_2)
3 ILE A  96
ASP A  44
PHE A  99
None
0.63A 1uwjB-1wczA:
undetectable
1uwjB-1wczA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
3 ILE A  88
ASP A  75
PHE A  23
None
0.41A 1uwjB-2b5mA:
undetectable
1uwjB-2b5mA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens)
PF00478
(IMPDH)
3 ILE A  51
ASP A 237
PHE A 232
None
0.64A 1uwjB-2bznA:
undetectable
1uwjB-2bznA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Pyrococcus
horikoshii)
PF00215
(OMPdecase)
3 ILE A 103
ASP A  80
PHE A  75
None
0.53A 1uwjB-2czdA:
undetectable
1uwjB-2czdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
3 ILE A 448
ASP A 361
PHE A 360
None
0.41A 1uwjB-2g39A:
undetectable
1uwjB-2g39A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2


(Homo sapiens)
PF00255
(GSHPx)
3 ILE A  14
ASP A  22
PHE A  23
None
0.52A 1uwjB-2he3A:
undetectable
1uwjB-2he3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A


(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
3 ILE A 226
ASP A 213
PHE A 214
None
0.55A 1uwjB-2inrA:
undetectable
1uwjB-2inrA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j67 TOLL LIKE RECEPTOR
10


(Homo sapiens)
PF01582
(TIR)
3 ILE A 638
ASP A 644
PHE A 700
None
0.66A 1uwjB-2j67A:
undetectable
1uwjB-2j67A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780


(Pyrococcus
abyssi)
PF05958
(tRNA_U5-meth_tr)
3 ILE A 362
ASP A 375
PHE A 372
None
0.62A 1uwjB-2jjqA:
undetectable
1uwjB-2jjqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z


(Saccharomyces
cerevisiae)
PF00125
(Histone)
PF16211
(Histone_H2A_C)
3 ILE A  69
ASP A  36
PHE A  33
None
0.44A 1uwjB-2jssA:
undetectable
1uwjB-2jssA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbf ATP-DEPENDENT RNA
HELICASE DBP5


(Saccharomyces
cerevisiae)
PF00271
(Helicase_C)
3 ILE A 475
ASP A 310
PHE A 439
None
0.54A 1uwjB-2kbfA:
undetectable
1uwjB-2kbfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhs CBP21

(Serratia
marcescens)
PF03067
(LPMO_10)
3 ILE A 147
ASP A 113
PHE A 112
None
0.63A 1uwjB-2lhsA:
undetectable
1uwjB-2lhsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2


(Homo sapiens)
PF13676
(TIR_2)
3 ILE A  83
ASP A  89
PHE A 143
None
0.53A 1uwjB-2m1wA:
undetectable
1uwjB-2m1wA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m2a FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Escherichia
coli)
PF00254
(FKBP_C)
3 ILE A 121
ASP A 124
PHE A 125
None
0.62A 1uwjB-2m2aA:
undetectable
1uwjB-2m2aA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus)
PF00183
(HSP90)
PF02518
(HATPase_c)
3 ILE A 210
ASP A 207
PHE A 203
None
0.59A 1uwjB-2o1vA:
undetectable
1uwjB-2o1vA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1l HYPOTHETICAL PROTEIN

(Vibrio cholerae)
PF10980
(DUF2787)
3 ILE A  62
ASP A  79
PHE A  80
None
0.50A 1uwjB-2v1lA:
undetectable
1uwjB-2v1lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE


(unidentified
phage)
PF09251
(PhageP22-tail)
3 ILE A 225
ASP A 204
PHE A 205
None
0.65A 1uwjB-2v5iA:
undetectable
1uwjB-2v5iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
3 ILE A 701
ASP A 720
PHE A 717
None
0.46A 1uwjB-2vcaA:
undetectable
1uwjB-2vcaA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82


(Saccharomyces
cerevisiae)
no annotation 3 ILE B 165
ASP B 168
PHE B 148
None
0.64A 1uwjB-2vduB:
undetectable
1uwjB-2vduB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvq SMALL S PROTEIN

(Podospora
anserina)
PF14479
(HeLo)
3 ILE A 207
ASP A  46
PHE A  25
None
0.58A 1uwjB-2wvqA:
undetectable
1uwjB-2wvqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN


(Clostridium
botulinum)
PF07952
(Toxin_trans)
3 ILE B 764
ASP B 767
PHE B 768
None
0.39A 1uwjB-2xhlB:
undetectable
1uwjB-2xhlB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
3 ILE A 367
ASP A 358
PHE A 359
None
0.61A 1uwjB-2xy9A:
undetectable
1uwjB-2xy9A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
3 ILE A 345
ASP A 336
PHE A 337
None
0.61A 1uwjB-2xydA:
undetectable
1uwjB-2xydA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Bacteroides
vulgatus)
PF00891
(Methyltransf_2)
3 ILE A 267
ASP A 324
PHE A 320
None
0.65A 1uwjB-3dp7A:
undetectable
1uwjB-3dp7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti)
PF13407
(Peripla_BP_4)
3 ILE A 310
ASP A 314
PHE A 315
None
0.65A 1uwjB-3ejwA:
undetectable
1uwjB-3ejwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhn PROTEIN TRANSPORT
PROTEIN TIP20


(Saccharomyces
cerevisiae)
PF04437
(RINT1_TIP1)
3 ILE A 595
ASP A 620
PHE A 617
None
0.55A 1uwjB-3fhnA:
undetectable
1uwjB-3fhnA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG


(Aquifex
aeolicus)
PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N)
3 ILE A 264
ASP A 292
PHE A 289
None
0.57A 1uwjB-3hjlA:
undetectable
1uwjB-3hjlA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
3 ILE A1028
ASP A1040
PHE A1041
None
None
8ST  A2001 ( 3.7A)
0.65A 1uwjB-3hngA:
27.9
1uwjB-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE


(uncultured
murine large
bowel bacterium
BAC 14)
PF00722
(Glyco_hydro_16)
3 ILE A 148
ASP A 145
PHE A 140
None
0.66A 1uwjB-3i4iA:
undetectable
1uwjB-3i4iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
PF02219
(MTHFR)
3 ILE A 170
ASP A 197
PHE A 194
None
0.58A 1uwjB-3ijdA:
undetectable
1uwjB-3ijdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE


(Thermotoga
maritima)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 ILE A 312
ASP A 305
PHE A 126
None
0.65A 1uwjB-3ip3A:
undetectable
1uwjB-3ip3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv1 P22 PROTEIN

(Trypanosoma
brucei)
PF02330
(MAM33)
3 ILE A  75
ASP A  82
PHE A  90
None
0.61A 1uwjB-3jv1A:
undetectable
1uwjB-3jv1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC


(Escherichia
coli)
PF13614
(AAA_31)
3 ILE A 561
ASP A 605
PHE A 604
None
0.66A 1uwjB-3la6A:
undetectable
1uwjB-3la6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1


(Homo sapiens)
PF00962
(A_deaminase)
PF08451
(A_deaminase_N)
3 ILE A 262
ASP A 297
PHE A 328
None
0.61A 1uwjB-3lggA:
undetectable
1uwjB-3lggA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI


(Bacteroides
ovatus)
PF00877
(NLPC_P60)
3 ILE A 180
ASP A 245
PHE A 306
GOL  A 332 ( 4.8A)
None
None
0.64A 1uwjB-3npfA:
undetectable
1uwjB-3npfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E


(Bacteroides
ovatus)
PF09471
(Peptidase_M64)
PF16217
(M64_N)
3 ILE A 278
ASP A 196
PHE A 193
None
0.67A 1uwjB-3p1vA:
undetectable
1uwjB-3p1vA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE


(Borreliella
burgdorferi)
PF01406
(tRNA-synt_1e)
3 ILE A  44
ASP A 108
PHE A 105
None
0.56A 1uwjB-3sp1A:
undetectable
1uwjB-3sp1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL


(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
3 ILE A1120
ASP A1213
PHE A1214
None
0.58A 1uwjB-3topA:
undetectable
1uwjB-3topA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum)
PF00104
(Hormone_recep)
3 ILE A 596
ASP A 590
PHE A 462
None
0.66A 1uwjB-3up3A:
undetectable
1uwjB-3up3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE


(Pseudoalteromonas
sp. BB1)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
3 ILE A  42
ASP A 317
PHE A 353
None
0.64A 1uwjB-3uszA:
undetectable
1uwjB-3uszA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
3 ILE A 181
ASP A 247
PHE A 248
GOL  A 706 ( 4.4A)
None
None
0.56A 1uwjB-3ve2A:
undetectable
1uwjB-3ve2A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE


(Streptococcus
pneumoniae)
PF00162
(PGK)
3 ILE A 362
ASP A 356
PHE A 326
None
ANP  A1401 (-3.4A)
None
0.45A 1uwjB-3zlbA:
undetectable
1uwjB-3zlbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA


(Salmonella
enterica)
PF03193
(RsgA_GTPase)
3 ILE V 219
ASP V 271
PHE V 266
None
0.59A 1uwjB-4a2iV:
undetectable
1uwjB-4a2iV:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 ILE A 164
ASP A 223
PHE A 220
None
0.53A 1uwjB-4bf5A:
undetectable
1uwjB-4bf5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE


(Trypanosoma
brucei)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
3 ILE A   7
ASP A 235
PHE A 258
None
None
GOL  A1298 ( 4.0A)
0.64A 1uwjB-4cjxA:
undetectable
1uwjB-4cjxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckk DNA GYRASE SUBUNIT A

(Escherichia
coli)
PF00521
(DNA_topoisoIV)
3 ILE A 229
ASP A 216
PHE A 217
None
0.58A 1uwjB-4ckkA:
0.2
1uwjB-4ckkA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora)
PF02435
(Glyco_hydro_68)
3 ILE A 144
ASP A  52
PHE A  53
None
0.63A 1uwjB-4d47A:
undetectable
1uwjB-4d47A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis)
PF00521
(DNA_topoisoIV)
3 ILE A 230
ASP A 217
PHE A 218
None
0.53A 1uwjB-4ddqA:
undetectable
1uwjB-4ddqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF09471
(Peptidase_M64)
PF16217
(M64_N)
3 ILE A 278
ASP A 196
PHE A 193
None
0.63A 1uwjB-4df9A:
undetectable
1uwjB-4df9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE


(Staphylococcus
aureus)
PF00162
(PGK)
3 ILE A 360
ASP A 354
PHE A 324
None
0.57A 1uwjB-4dg5A:
undetectable
1uwjB-4dg5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)


(Agrobacterium
fabrum)
PF13416
(SBP_bac_8)
3 ILE A 165
ASP A 172
PHE A 145
None
0.63A 1uwjB-4euoA:
undetectable
1uwjB-4euoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA


(Streptococcus
pneumoniae)
PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c)
3 ILE A1225
ASP A1212
PHE A1213
None
0.57A 1uwjB-4i3hA:
0.2
1uwjB-4i3hA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR


(Streptococcus
pyogenes)
PF01475
(FUR)
3 ILE A 139
ASP A 112
PHE A 113
None
0.56A 1uwjB-4i7hA:
undetectable
1uwjB-4i7hA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
3 ILE A 268
ASP A 254
PHE A 251
None
0.61A 1uwjB-4mlaA:
undetectable
1uwjB-4mlaA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL


(Homo sapiens)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
3 ILE D 885
ASP D 951
PHE D 947
MLY  D 884 ( 4.0A)
None
MLY  D 946 ( 4.7A)
0.59A 1uwjB-4ngeD:
1.8
1uwjB-4ngeD:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofs PROBABLE LIPOAMIDE
ACYLTRANSFERASE


(Thermoplasma
acidophilum)
PF00198
(2-oxoacid_dh)
3 ILE A  66
ASP A 209
PHE A 206
None
0.66A 1uwjB-4ofsA:
undetectable
1uwjB-4ofsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS


(Escherichia
coli)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
3 ILE A 276
ASP A 283
PHE A 284
None
0.59A 1uwjB-4pdxA:
undetectable
1uwjB-4pdxA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
3 ILE A 709
ASP A 713
PHE A 714
None
0.57A 1uwjB-4pj3A:
undetectable
1uwjB-4pj3A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A


(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
3 ILE B1230
ASP B1217
PHE B1218
None
0.52A 1uwjB-4plbB:
2.5
1uwjB-4plbB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN


(Bacteroides
fragilis)
PF01368
(DHH)
3 ILE A  26
ASP A  99
PHE A 100
None
0.46A 1uwjB-4py9A:
undetectable
1uwjB-4py9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
3 ILE A 317
ASP A  47
PHE A  44
None
0.54A 1uwjB-4qs9A:
undetectable
1uwjB-4qs9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1j GU4 NUCLEIC-BINDING
PROTEIN 1


(Saccharomyces
cerevisiae)
PF01588
(tRNA_bind)
3 ILE A 126
ASP A  10
PHE A  11
None
0.57A 1uwjB-4r1jA:
undetectable
1uwjB-4r1jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr4 TYPE III
IODOTHYRONINE
DEIODINASE


(Mus musculus)
PF00837
(T4_deiodinase)
3 ILE A 115
ASP A 124
PHE A 125
None
0.59A 1uwjB-4tr4A:
undetectable
1uwjB-4tr4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
3 ILE A  81
ASP A 117
PHE A 118
None
0.66A 1uwjB-4wzbA:
undetectable
1uwjB-4wzbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620)
no annotation 3 ILE A 299
ASP A 270
PHE A 271
None
0.60A 1uwjB-4xn3A:
undetectable
1uwjB-4xn3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yds FLAGELLA-RELATED
PROTEIN H


(Sulfolobus
acidocaldarius)
PF06745
(ATPase)
3 ILE A 153
ASP A 117
PHE A  44
None
0.60A 1uwjB-4ydsA:
undetectable
1uwjB-4ydsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001)
PF01425
(Amidase)
3 ILE A 460
ASP A 393
PHE A 389
None
0.59A 1uwjB-4yjiA:
undetectable
1uwjB-4yjiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE


(Eimeria tenella)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
3 ILE A 307
ASP A 392
PHE A 393
None
CA  A 502 (-3.1A)
None
0.60A 1uwjB-4ysjA:
24.3
1uwjB-4ysjA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae)
PF00521
(DNA_topoisoIV)
3 ILE A 227
ASP A 214
PHE A 215
None
0.59A 1uwjB-4z2eA:
2.6
1uwjB-4z2eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE


(Streptococcus
pneumoniae)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
3 ILE A1225
ASP A1212
PHE A1213
None
0.57A 1uwjB-4z3oA:
undetectable
1uwjB-4z3oA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
3 ILE A 511
ASP A 378
PHE A 375
None
0.63A 1uwjB-4zr5A:
undetectable
1uwjB-4zr5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME


(Drosophila
melanogaster)
PF01401
(Peptidase_M2)
3 ILE A 351
ASP A 342
PHE A 343
None
0.64A 1uwjB-5a2rA:
undetectable
1uwjB-5a2rA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT


(Sulfurisphaera
tokodaii)
PF01558
(POR)
PF01855
(POR_N)
3 ILE A 364
ASP A 359
PHE A 320
None
0.50A 1uwjB-5b48A:
undetectable
1uwjB-5b48A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
3 ILE A 230
ASP A 217
PHE A 218
ILE  A 230 ( 0.7A)
ASP  A 217 ( 0.5A)
PHE  A 218 ( 1.3A)
0.57A 1uwjB-5cdnA:
1.8
1uwjB-5cdnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
3 ILE A  88
ASP A  75
PHE A  23
None
0.30A 1uwjB-5fqdA:
undetectable
1uwjB-5fqdA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
3 ILE A 176
ASP A 243
PHE A 185
None
0.66A 1uwjB-5gmsA:
undetectable
1uwjB-5gmsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
3 ILE A 267
ASP A 198
PHE A 199
None
6GA  A1015 (-3.1A)
None
0.58A 1uwjB-5j6sA:
undetectable
1uwjB-5j6sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npt TELOMERASE REVERSE
TRANSCRIPTASE


(Ogataea
polymorpha)
no annotation 3 ILE A 115
ASP A   4
PHE A   3
None
0.61A 1uwjB-5nptA:
undetectable
1uwjB-5nptA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 3 ILE A 453
ASP A 418
PHE A 438
None
0.66A 1uwjB-5obuA:
undetectable
1uwjB-5obuA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli)
PF01965
(DJ-1_PfpI)
3 ILE A 101
ASP A 147
PHE A 119
None
0.59A 1uwjB-5sy4A:
undetectable
1uwjB-5sy4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
3 ILE A  40
ASP A 273
PHE A 295
None
0.64A 1uwjB-5tc4A:
undetectable
1uwjB-5tc4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubj ALPHA-L-ARABINOFURAN
OSIDASE AXHA-2


(Aspergillus
nidulans)
PF03664
(Glyco_hydro_62)
3 ILE A 186
ASP A 287
PHE A 105
None
0.61A 1uwjB-5ubjA:
undetectable
1uwjB-5ubjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11


(Homo sapiens)
no annotation 3 ILE X 217
ASP X 211
PHE X 232
None
0.66A 1uwjB-5vfrX:
undetectable
1uwjB-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE


(Malbranchea
aurantiaca)
PF04820
(Trp_halogenase)
3 ILE A  69
ASP A 169
PHE A 170
None
None
FAD  A 701 (-4.5A)
0.57A 1uwjB-5wgxA:
undetectable
1uwjB-5wgxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14


(Saccharomyces
cerevisiae)
PF00782
(DSPc)
PF14671
(DSPn)
3 ILE A 139
ASP A  50
PHE A  51
None
0.39A 1uwjB-5xw5A:
undetectable
1uwjB-5xw5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqq MEMBRANE-ANCHORED
LIPID-BINDING
PROTEIN YSP2


(Saccharomyces
cerevisiae)
no annotation 3 ILE A1136
ASP A1140
PHE A1144
None
0.64A 1uwjB-5yqqA:
undetectable
1uwjB-5yqqA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri)
no annotation 3 ILE A 161
ASP A 382
PHE A 381
None
0.63A 1uwjB-6bljA:
1.4
1uwjB-6bljA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum)
no annotation 3 ILE J 175
ASP J 137
PHE J 140
None
0.58A 1uwjB-6fhsJ:
undetectable
1uwjB-6fhsJ:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A


(Mus musculus)
no annotation 3 ILE A 535
ASP A 504
PHE A 502
None
0.57A 1uwjB-6fnwA:
undetectable
1uwjB-6fnwA:
16.54