SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWJ_A_BAXA1723_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 424
ILE A  47
ILE A  89
ASP A  44
 None
 0.72A 1uwjA-1ewkA:
undetectable		 1uwjA-1ewkA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  62
LYS A  85
ILE A 109
ILE A 177
 None
 0.73A 1uwjA-1gngA:
8.1		 1uwjA-1gngA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  10
LYS A  33
LEU A  55
ILE A  63
 None
 0.84A 1uwjA-1h4lA:
5.5		 1uwjA-1h4lA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		4 ILE A  88
LEU A 123
ILE A 121
ASP A  48
 None
 0.86A 1uwjA-1hylA:
undetectable		 1uwjA-1hylA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of9 PORE-FORMING PEPTIDE
AMEOBAPORE A

(Entamoeba
histolytica) 		PF03489
(SapB_2) 		4 LEU A  18
ILE A  31
ILE A  58
ASP A  25
 None
 0.64A 1uwjA-1of9A:
undetectable		 1uwjA-1of9A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 ILE A 211
LYS A 232
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.9A)
None
None
 0.60A 1uwjA-1py5A:
6.5		 1uwjA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LYS A 187
LEU A 206
ILE A 225
ILE A 290
 ADP  A 810 (-3.1A)
None
None
None
 0.51A 1uwjA-1q8yA:
5.5		 1uwjA-1q8yA:
24.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 623
LEU A 644
ILE A 653
ASP A 810
 STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
None
STI  A   3 (-3.9A)
 0.55A 1uwjA-1t46A:
28.2		 1uwjA-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvc METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 201
ILE A 214
ILE A 235
ASP A 209
 None
 0.72A 1uwjA-1tvcA:
undetectable		 1uwjA-1tvcA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 ILE A 215
ILE A 327
ILE A 290
ASP A 247
 None
 0.82A 1uwjA-1v5cA:
undetectable		 1uwjA-1v5cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica) 		PF00270
(DEAD) 		4 ILE A 183
LEU A 374
ILE A 242
ILE A 266
 None
 0.83A 1uwjA-1wrbA:
undetectable		 1uwjA-1wrbA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE B 273
LYS B 296
LEU B 312
ILE B 320
 None
 0.81A 1uwjA-2a1aB:
21.9		 1uwjA-2a1aB:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 ILE A 442
LEU A 520
ILE A 427
ASP A 433
 None
 0.83A 1uwjA-2d7dA:
undetectable		 1uwjA-2d7dA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9z PROTEIN KINASE C, NU
TYPE

(Homo sapiens) 		PF00169
(PH) 		4 LEU A  53
ILE A 118
ILE A  51
ASP A  32
 None
 0.81A 1uwjA-2d9zA:
undetectable		 1uwjA-2d9zA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga8 HYPOTHETICAL 39.9
KDA PROTEIN

(Saccharomyces
cerevisiae) 		PF07728
(AAA_5) 		4 ILE A 347
LEU A  44
ILE A 262
ASP A  10
 None
CME  A  45 ( 3.7A)
None
None
 0.86A 1uwjA-2ga8A:
undetectable		 1uwjA-2ga8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  78
LEU A  98
ILE A 107
ILE A 166
 None
 0.74A 1uwjA-2hw6A:
22.3		 1uwjA-2hw6A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 ILE A 428
LYS A 454
ILE A 483
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.7A)
 0.86A 1uwjA-2j0jA:
11.6		 1uwjA-2j0jA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 428
LYS A 454
ILE A 483
ASP A 564
 BII  A1687 (-3.8A)
BII  A1687 (-2.9A)
None
None
 0.75A 1uwjA-2jkmA:
28.1		 1uwjA-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 ILE A  80
LYS A  19
ILE A 188
ASP A 174
 None
ASP  A1234 (-2.9A)
None
ASP  A1234 (-2.8A)
 0.81A 1uwjA-2v25A:
undetectable		 1uwjA-2v25A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 424
LYS A 447
LEU A 463
ILE A 472
 None
 0.67A 1uwjA-2wntA:
19.8		 1uwjA-2wntA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 627
LYS A 653
ILE A 682
ASP A 764
 None
Q9G  A1898 (-4.8A)
None
None
 0.83A 1uwjA-2xyuA:
7.8		 1uwjA-2xyuA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  30
LEU A  81
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.88A 1uwjA-2y7jA:
7.4		 1uwjA-2y7jA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  30
LYS A  53
LEU A  81
ILE A  90
 B49  A1294 (-3.9A)
None
None
None
 0.75A 1uwjA-2y7jA:
7.4		 1uwjA-2y7jA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		4 LYS A  42
LEU A  68
ILE A  76
ILE A 135
 AMP  A1302 (-2.8A)
None
None
None
 0.49A 1uwjA-2yabA:
6.7		 1uwjA-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 123
LEU A 147
ILE A 155
ILE A 214
 STU  A 400 ( 4.3A)
None
None
None
 0.68A 1uwjA-3a62A:
6.8		 1uwjA-3a62A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 LEU A 147
ILE A  70
ILE A  76
PHE A  88
 None
 0.90A 1uwjA-3bxaA:
undetectable		 1uwjA-3bxaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A1028
LEU A1056
ILE A1064
ILE A1124
 ADP  A   1 (-3.0A)
None
None
None
 0.64A 1uwjA-3dlsA:
7.5		 1uwjA-3dlsA:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 150
LYS A 171
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
None
None
None
VIN  A6331 (-4.0A)
 1.07A 1uwjA-3dtcA:
12.8		 1uwjA-3dtcA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS X  69
LEU X  86
ILE X  95
ILE X 153
 CCK  X 351 (-3.5A)
None
None
None
 0.82A 1uwjA-3e3bX:
5.8		 1uwjA-3e3bX:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  32
LYS A  55
LEU A  77
ASP A 169
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.6A)
None
None
 0.75A 1uwjA-3e7oA:
6.5		 1uwjA-3e7oA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  32
LYS A  55
LEU A  77
ILE A  85
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.6A)
None
None
 0.77A 1uwjA-3e7oA:
6.5		 1uwjA-3e7oA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fuy PUTATIVE INTEGRON
GENE CASSETTE
PROTEIN

(uncultured
bacterium) 		no annotation 4 ILE A 122
ILE A  73
ILE A  16
ASP A  46
 None
 0.88A 1uwjA-3fuyA:
undetectable		 1uwjA-3fuyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 209
LYS A 230
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-2.8A)
None
None
 0.70A 1uwjA-3g2fA:
6.5		 1uwjA-3g2fA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  59
LYS A  82
ILE A 112
ASP A 193
 None
 0.78A 1uwjA-3iecA:
6.6		 1uwjA-3iecA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  59
LYS A  82
ILE A 112
ILE A 171
 None
 0.88A 1uwjA-3iecA:
6.6		 1uwjA-3iecA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		4 LEU A  31
ILE A  14
ILE A 129
ASP A 124
 None
 0.85A 1uwjA-3ktoA:
undetectable		 1uwjA-3ktoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)

(Sulfolobus
solfataricus) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		4 LYS A 321
ILE A 262
ILE A 333
ASP A 329
 None
None
SCN  A 366 (-3.5A)
None
 0.81A 1uwjA-3kxiA:
undetectable		 1uwjA-3kxiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A 581
LEU A 600
ILE A 613
ASP A 720
 ANP  A 877 (-2.7A)
None
None
ANP  A 877 (-2.9A)
 0.75A 1uwjA-3lltA:
7.2		 1uwjA-3lltA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		4 ILE A 210
LYS A 231
ILE A 258
ILE A 328
 LDN  A   1 (-4.1A)
None
None
None
 0.83A 1uwjA-3mdyA:
6.6		 1uwjA-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE B1013
LEU A  41
ILE A  73
ILE A 160
 None
 0.78A 1uwjA-3myrB:
undetectable		 1uwjA-3myrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  51
LEU A  73
ILE A  81
ILE A 140
 ADP  A 314 (-2.8A)
None
None
None
 0.61A 1uwjA-3nizA:
5.8		 1uwjA-3nizA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 4 LEU B 300
ILE B 314
ILE B 329
ASP B 309
 None
 0.83A 1uwjA-3ogkB:
undetectable		 1uwjA-3ogkB:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 355
LYS A 375
LEU A 397
ILE A 405
ILE A 464
 SM5  A   1 (-4.3A)
SM5  A   1 (-3.5A)
None
None
None
 0.71A 1uwjA-3omvA:
13.2		 1uwjA-3omvA:
72.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 LEU A 217
ILE A 140
ILE A 146
PHE A 158
 None
 0.88A 1uwjA-3rwaA:
undetectable		 1uwjA-3rwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN

(Leishmania
major) 		PF00782
(DSPc) 		4 LEU A 127
ILE A 142
ILE A 158
ASP A 137
 None
 0.83A 1uwjA-3s4oA:
undetectable		 1uwjA-3s4oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A 179
LEU A  40
ILE A  79
PHE A 129
 None
 0.89A 1uwjA-3s8dA:
undetectable		 1uwjA-3s8dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 592
ILE A 600
ASP A 697
PHE A 698
 0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.76A 1uwjA-3v5qA:
8.3		 1uwjA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqs LAMININ SUBUNIT
BETA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 ILE A 177
LEU A 227
ILE A 216
ASP A 211
 None
 0.76A 1uwjA-4aqsA:
undetectable		 1uwjA-4aqsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ILE A  66
LEU A  81
ILE A  97
ILE A  51
 None
 0.71A 1uwjA-4ay1A:
undetectable		 1uwjA-4ay1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  61
LYS A  84
LEU A 106
ILE A 114
ASP A 200
 R4L  A1394 (-4.0A)
None
None
None
None
 0.76A 1uwjA-4b99A:
5.5		 1uwjA-4b99A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE

(Drosophila
melanogaster) 		PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		4 ILE A 373
ILE A 427
ILE A 319
ASP A 402
 None
 0.79A 1uwjA-4c0jA:
undetectable		 1uwjA-4c0jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  64
LYS A  90
LEU A 108
ILE A 173
 None
ADP  A 601 (-2.6A)
None
None
 0.88A 1uwjA-4f99A:
5.1		 1uwjA-4f99A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 4 LEU A 138
ILE A  84
ILE A  48
ASP A  81
 None
 0.87A 1uwjA-4fekA:
undetectable		 1uwjA-4fekA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 LEU A 136
ILE A 348
ILE A 302
ASP A 345
 None
 0.72A 1uwjA-4j9vA:
undetectable		 1uwjA-4j9vA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 366
ILE A 133
ILE A 191
ASP A 184
 None
 0.80A 1uwjA-4jr7A:
4.6		 1uwjA-4jr7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LYS A  69
LEU A  86
ILE A 133
ILE A 191
 GNP  A 401 (-3.3A)
None
None
None
 0.61A 1uwjA-4jr7A:
4.6		 1uwjA-4jr7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		4 LEU A  22
ILE A   8
ILE A 127
ASP A   5
 None
 0.89A 1uwjA-4k22A:
undetectable		 1uwjA-4k22A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ILE A 389
LYS A 387
LEU A 457
ASP A 267
 None
 0.74A 1uwjA-4kc8A:
undetectable		 1uwjA-4kc8A:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A  63
LEU A  81
ILE A  89
ASP A 175
 None
None
None
1UL  A 501 (-4.2A)
 0.85A 1uwjA-4l52A:
10.3		 1uwjA-4l52A:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS E  68
LEU E  85
ILE E  94
ILE E 152
 None
 0.62A 1uwjA-4md8E:
4.8		 1uwjA-4md8E:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9x PUTATIVE
MONOOXYGENASE

(Pectobacterium
atrosepticum) 		PF01494
(FAD_binding_3) 		4 LEU A  22
ILE A   8
ILE A 127
ASP A   5
 None
 0.84A 1uwjA-4n9xA:
undetectable		 1uwjA-4n9xA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 ILE B 174
ILE B  56
ILE B  97
PHE B 275
 None
 0.89A 1uwjA-4ouaB:
undetectable		 1uwjA-4ouaB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 ILE A 174
ILE A  56
ILE A  97
PHE A 275
 None
 0.89A 1uwjA-4ouaA:
undetectable		 1uwjA-4ouaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		4 ILE A 131
LEU A 114
ILE A 181
ASP A 175
 None
 0.82A 1uwjA-4p6bA:
undetectable		 1uwjA-4p6bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 ILE A  27
LEU A  74
ILE A  82
ASP A 167
 ANP  A 402 (-4.6A)
None
None
ANP  A 402 ( 2.6A)
 0.84A 1uwjA-4qnyA:
22.2		 1uwjA-4qnyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 ILE A  27
LYS A  51
LEU A  74
ILE A  82
 ANP  A 402 (-4.6A)
ANP  A 402 (-2.8A)
None
None
 0.72A 1uwjA-4qnyA:
22.2		 1uwjA-4qnyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ILE A 642
ILE A 746
ILE A 794
PHE A 682
 None
 0.88A 1uwjA-4rt6A:
undetectable		 1uwjA-4rt6A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		4 LEU A 591
ILE A 191
ASP A 186
PHE A 210
 None
 0.81A 1uwjA-4uirA:
undetectable		 1uwjA-4uirA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 ILE A  29
LEU A  73
ILE A  81
ASP A 165
 42A  A 402 ( 4.7A)
None
None
None
 0.85A 1uwjA-4xrlA:
21.9		 1uwjA-4xrlA:
27.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 469
LYS A 490
LEU A 513
ILE A 584
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.9A)
None
None
 0.75A 1uwjA-4yffA:
26.2		 1uwjA-4yffA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 165
LYS A 188
LEU A 207
ILE A 221
ILE A 283
 4E1  A 505 ( 4.6A)
4E1  A 505 (-2.7A)
None
None
None
 0.64A 1uwjA-4yljA:
6.5		 1uwjA-4yljA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LYS A  57
LEU A  80
ILE A  88
ILE A 147
 ADP  A 506 (-2.4A)
None
None
None
 0.53A 1uwjA-4ysjA:
7.0		 1uwjA-4ysjA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		4 ILE A 180
ILE A 279
ILE A 236
ASP A 242
 None
 0.83A 1uwjA-5advA:
undetectable		 1uwjA-5advA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 ILE A 328
LEU A 315
ILE A 276
ILE A 303
 None
 0.84A 1uwjA-5c9eA:
undetectable		 1uwjA-5c9eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ILE A  69
LYS A  92
LEU A 114
ILE A 122
ASP A 207
 None
 1.02A 1uwjA-5ci6A:
7.8		 1uwjA-5ci6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clr LEGK4

(Legionella
pneumophila) 		PF00069
(Pkinase) 		4 LEU A  27
ILE A  36
ILE A  72
ASP A  96
 None
 0.87A 1uwjA-5clrA:
15.7		 1uwjA-5clrA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		4 ILE A  42
ILE A  19
ASP A  65
PHE A  66
 None
 0.79A 1uwjA-5dgqA:
undetectable		 1uwjA-5dgqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 LEU A 819
ILE A 790
ILE A 858
ASP A 812
 None
 0.81A 1uwjA-5dmyA:
undetectable		 1uwjA-5dmyA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ILE A 540
LYS A 563
ILE A 594
ASP A 675
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
 0.87A 1uwjA-5ezrA:
10.3		 1uwjA-5ezrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ILE A 540
LYS A 563
ILE A 594
ILE A 653
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
 0.87A 1uwjA-5ezrA:
10.3		 1uwjA-5ezrA:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
LYS A 483
ILE A 513
ILE A 572
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-3.8A)
None
None
 0.59A 1uwjA-5fd2A:
35.4		 1uwjA-5fd2A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 ILE A 169
ILE A  16
ILE A  78
PHE A  58
 None
 0.84A 1uwjA-5fgnA:
undetectable		 1uwjA-5fgnA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu4 CYSTEINE PROTEASE

(Listeria
monocytogenes) 		PF04203
(Sortase) 		4 LEU A  53
ILE A  77
ILE A  68
PHE A 148
 None
 0.89A 1uwjA-5hu4A:
undetectable		 1uwjA-5hu4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 LEU A  49
ILE A 249
ILE A 139
ASP A  56
 None
 0.85A 1uwjA-5infA:
undetectable		 1uwjA-5infA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 276
LYS A 299
ILE A 327
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.5A)
None
None
 0.82A 1uwjA-5kbrA:
7.4		 1uwjA-5kbrA:
30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 155
LYS A 178
LEU A 197
ILE A 271
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.5A)
None
None
 0.78A 1uwjA-5lxdA:
7.6		 1uwjA-5lxdA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1

(Homo sapiens) 		no annotation 4 ILE A  15
LEU A  29
ILE A  43
ILE A  91
 None
None
GOL  A 203 (-4.5A)
None
 0.89A 1uwjA-5onsA:
undetectable		 1uwjA-5onsA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 ILE A 223
LEU A 184
ILE A 135
ILE A 168
 None
None
None
MLY  A 169 ( 3.7A)
 0.81A 1uwjA-5thmA:
undetectable		 1uwjA-5thmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 ILE A  17
LEU A  61
ILE A  69
ASP A 150
 7LV  A 401 (-4.3A)
None
None
7LV  A 401 (-4.2A)
 0.89A 1uwjA-5tvtA:
7.3		 1uwjA-5tvtA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 ILE A  17
LYS A  40
LEU A  61
ILE A  69
 7LV  A 401 (-4.3A)
7LV  A 401 (-3.0A)
None
None
 0.75A 1uwjA-5tvtA:
7.3		 1uwjA-5tvtA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 364
LEU A 288
ILE A 329
PHE A 354
 None
 0.90A 1uwjA-5u7qA:
7.6		 1uwjA-5u7qA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v07 EXONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE Z 125
LEU Z 155
ILE Z  74
PHE Z  77
 None
 0.86A 1uwjA-5v07Z:
undetectable		 1uwjA-5v07Z:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 ILE A 145
LEU A 211
ILE A 389
ILE A 218
 None
 0.74A 1uwjA-5x09A:
undetectable		 1uwjA-5x09A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 4 ILE A 390
LEU A  11
ILE A  34
ILE A  16
 None
 0.85A 1uwjA-5xgwA:
undetectable		 1uwjA-5xgwA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE A  49
LYS A  72
LEU A  89
ILE A  98
ILE A 156
 ATP  A 403 (-4.9A)
ATP  A 403 (-3.2A)
None
None
None
 0.70A 1uwjA-5xvuA:
6.2		 1uwjA-5xvuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 4 ILE A 215
LYS A 238
LEU A 257
ILE A 331
 None
HRM  A 601 (-3.3A)
None
None
 0.80A 1uwjA-5y86A:
6.3		 1uwjA-5y86A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 ILE A 531
LEU A 575
ILE A 585
ASP A 664
 CQ7  A 801 (-3.6A)
None
None
None
 0.79A 1uwjA-6b4wA:
10.7		 1uwjA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 ILE A 531
LYS A 553
LEU A 575
ILE A 585
 CQ7  A 801 (-3.6A)
CQ7  A 801 (-3.2A)
None
None
 0.82A 1uwjA-6b4wA:
10.7		 1uwjA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 4 ILE A 495
ILE A 383
ILE A 467
PHE A 476
 None
 0.88A 1uwjA-6d6vA:
undetectable		 1uwjA-6d6vA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 4 ILE C 165
LYS C 193
ILE C 246
ILE C 330
 None
 0.64A 1uwjA-6eqiC:
8.2		 1uwjA-6eqiC:
24.12