SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWJ_A_BAXA1723

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.58A 1uwjA-1k9aA:
7.7		 1uwjA-1k9aA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		6 VAL A 296
ALA A 292
LEU A 224
HIS A 204
GLY A 225
SER A 366
 None
 1.43A 1uwjA-1ofeA:
undetectable		 1uwjA-1ofeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 275
ALA A 288
GLU A 305
THR A 334
LEU A 373
HIS A 380
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
 0.66A 1uwjA-1opkA:
7.1		 1uwjA-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 219
ALA A 230
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.51A 1uwjA-1py5A:
6.5		 1uwjA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
 0.51A 1uwjA-1rjbA:
7.7		 1uwjA-1rjbA:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
THR A 670
CYH A 673
LEU A 783
HIS A 790
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
 0.66A 1uwjA-1t46A:
28.2		 1uwjA-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 352
ALA A 367
GLU A 386
LEU A 452
HIS A 459
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
 0.52A 1uwjA-1u59A:
7.2		 1uwjA-1u59A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.75A 1uwjA-1u5qA:
7.1		 1uwjA-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
None
 0.58A 1uwjA-1zltA:
6.8		 1uwjA-1zltA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 None
GOL  A3001 (-3.5A)
None
None
None
 0.55A 1uwjA-2a2aA:
6.6		 1uwjA-2a2aA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
None
None
None
 0.75A 1uwjA-2gcdA:
7.9		 1uwjA-2gcdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
HIS A 752
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
None
 0.92A 1uwjA-2henA:
27.8		 1uwjA-2henA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.64A 1uwjA-2j0jA:
11.6		 1uwjA-2j0jA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		6 VAL A 116
ALA A 107
THR A  81
THR A 104
GLY A 187
SER A 127
 None
 1.34A 1uwjA-2jfwA:
undetectable		 1uwjA-2jfwA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.1A)
None
None
BII  A1687 ( 3.9A)
 0.74A 1uwjA-2jkmA:
28.1		 1uwjA-2jkmA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
GLU A 288
THR A 316
HIS A 362
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
 0.51A 1uwjA-2og8A:
8.1		 1uwjA-2og8A:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
THR A 663
CYH A 666
LEU A 769
HIS A 776
GLY A 795
 None
 0.57A 1uwjA-2ogvA:
11.4		 1uwjA-2ogvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 495
ALA A 515
GLU A 534
LEU A 617
HIS A 624
 None
 0.47A 1uwjA-2psqA:
7.5		 1uwjA-2psqA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.88A 1uwjA-2qluA:
6.5		 1uwjA-2qluA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
GLU A 724
THR A 753
LEU A 791
HIS A 798
 None
 0.88A 1uwjA-2r2pA:
7.5		 1uwjA-2r2pA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
 0.51A 1uwjA-2w4kA:
6.8		 1uwjA-2w4kA:
26.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
 0.52A 1uwjA-2xikA:
7.8		 1uwjA-2xikA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
THR A 699
LEU A 737
HIS A 744
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.5A)
None
None
 0.43A 1uwjA-2xyuA:
7.8		 1uwjA-2xyuA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
None
 0.57A 1uwjA-2yabA:
6.7		 1uwjA-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 313
ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.56A 1uwjA-2z2wA:
22.9		 1uwjA-2z2wA:
26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1010
ALA A1028
GLU A1047
LEU A1123
HIS A1130
GLY A1149
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
None
None
 0.76A 1uwjA-2z8cA:
8.2		 1uwjA-2z8cA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 None
C4F  A   1 (-3.3A)
None
None
None
 0.50A 1uwjA-3c4fA:
7.5		 1uwjA-3c4fA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.58A 1uwjA-3d7uA:
7.7		 1uwjA-3d7uA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  38
ALA A  51
GLU A  71
THR A 106
HIS A 148
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
 0.53A 1uwjA-3gp0A:
5.6		 1uwjA-3gp0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 841
ALA A 859
GLU A 878
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.61A 1uwjA-3hngA:
8.2		 1uwjA-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.58A 1uwjA-3kulA:
7.9		 1uwjA-3kulA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 689
ALA A 700
GLU A 715
CYH A 748
LEU A 788
HIS A 795
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
ADP  A2101 (-4.2A)
None
None
 0.60A 1uwjA-3lj0A:
7.8		 1uwjA-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 VAL A 218
ALA A 229
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
 0.71A 1uwjA-3mdyA:
6.6		 1uwjA-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
None
 0.53A 1uwjA-3my0A:
9.5		 1uwjA-3my0A:
27.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 363
ALA A 373
GLU A 393
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
 0.96A 1uwjA-3omvA:
13.2		 1uwjA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 363
ALA A 373
THR A 400
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
 0.71A 1uwjA-3omvA:
13.2		 1uwjA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1096
ALA A1112
LEU A1144
LEU A1199
HIS A1206
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
None
None
 0.54A 1uwjA-3plsA:
7.2		 1uwjA-3plsA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 VAL A 565
ALA A 576
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
None
None
 0.70A 1uwjA-3ppzA:
8.0		 1uwjA-3ppzA:
39.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 1uwjA-3q4tA:
6.9		 1uwjA-3q4tA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  71
ALA A  84
GLU A 115
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
None
None
 0.68A 1uwjA-3q5iA:
7.2		 1uwjA-3q5iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B 603
ALA B 616
GLU B 635
CYH B 889
HIS B 933
GLY B 952
 None
 0.76A 1uwjA-3qd2B:
21.5		 1uwjA-3qd2B:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 431
ALA A 443
THR A 489
LEU A 527
HIS A 534
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
None
None
 0.47A 1uwjA-3sxsA:
26.7		 1uwjA-3sxsA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
None
 0.46A 1uwjA-3tt0A:
7.3		 1uwjA-3tt0A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 303
ALA A 315
GLU A 334
LEU A 347
LEU A 404
HIS A 414
GLY A 433
 None
 1.14A 1uwjA-3ulzA:
6.3		 1uwjA-3ulzA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 552
ALA A 570
LEU A 670
HIS A 677
GLY A 696
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-3.3A)
 0.53A 1uwjA-3v5qA:
8.3		 1uwjA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
None
None
 0.71A 1uwjA-3vidA:
7.7		 1uwjA-3vidA:
27.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
None
None
 0.65A 1uwjA-3wzdA:
7.8		 1uwjA-3wzdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1959
ALA A1978
LEU A2010
LEU A2070
HIS A2077
GLY A2101
 None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
 0.82A 1uwjA-3zbfA:
10.4		 1uwjA-3zbfA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
GLU A 668
THR A 697
LEU A 735
HIS A 742
 None
 0.75A 1uwjA-3zfxA:
7.6		 1uwjA-3zfxA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwjA-4a4lA:
6.7		 1uwjA-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
None
None
 0.66A 1uwjA-4agdA:
7.2		 1uwjA-4agdA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  31
GLU A  51
CYH A  83
HIS A 124
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
D15  A 500 (-4.3A)
None
 0.39A 1uwjA-4aguA:
24.0		 1uwjA-4aguA:
25.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
HIS A 214
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
None
 0.87A 1uwjA-4aw5A:
28.4		 1uwjA-4aw5A:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.56A 1uwjA-4b6lA:
6.6		 1uwjA-4b6lA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  50
ALA A  63
GLU A  81
CYH A 113
LEU A 148
HIS A 155
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-3.7A)
None
None
 0.74A 1uwjA-4bc6A:
22.0		 1uwjA-4bc6A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 222
ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.48A 1uwjA-4c02A:
6.9		 1uwjA-4c02A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 653
GLU A 672
THR A 701
LEU A 757
HIS A 764
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
 0.69A 1uwjA-4ckrA:
7.8		 1uwjA-4ckrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 863
ALA A 880
GLU A 898
LEU A 967
HIS A 974
GLY A 993
 None
IZA  A2001 (-3.4A)
None
None
None
None
 0.84A 1uwjA-4gl9A:
9.7		 1uwjA-4gl9A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
THR A 205
LEU A 243
HIS A 250
GLY A 269
 None
 0.55A 1uwjA-4hzsA:
10.8		 1uwjA-4hzsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.63A 1uwjA-4i6fA:
22.7		 1uwjA-4i6fA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 ALA A  66
GLU A  87
CYH A 119
LEU A 153
HIS A 160
GLY A 179
 None
 0.76A 1uwjA-4j7bA:
24.0		 1uwjA-4j7bA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
LEU A  73
CYH A  92
LEU A 127
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
 0.33A 1uwjA-4jxfA:
19.1		 1uwjA-4jxfA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
GLU A  70
CYH A 102
LEU A 137
HIS A 144
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.0A)
None
None
 1.05A 1uwjA-4lg4A:
7.1		 1uwjA-4lg4A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
None
 0.69A 1uwjA-4m69A:
7.4		 1uwjA-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  86
ALA A  99
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
None
None
 0.76A 1uwjA-4mvfA:
20.6		 1uwjA-4mvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B  38
ALA B  51
GLU B  70
LEU B 135
HIS B 142
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
 0.45A 1uwjA-4o27B:
7.5		 1uwjA-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
GLU A  85
THR A 123
CYH A 126
HIS A 171
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.54A 1uwjA-4o38A:
20.6		 1uwjA-4o38A:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 235
ALA A 248
THR A 301
LEU A 338
HIS A 347
GLY A 367
 None
 0.80A 1uwjA-4pwnA:
10.2		 1uwjA-4pwnA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.46A 1uwjA-4rt7A:
10.2		 1uwjA-4rt7A:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 0.85A 1uwjA-4ueuA:
11.4		 1uwjA-4ueuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
ALA A  72
GLU A  90
CYH A 129
LEU A 165
HIS A 174
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
None
None
 0.82A 1uwjA-4wsqA:
5.5		 1uwjA-4wsqA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 481
ALA A 501
GLU A 520
LEU A 603
HIS A 610
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
None
 0.45A 1uwjA-4xcuA:
27.0		 1uwjA-4xcuA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 416
ALA A 428
THR A 474
LEU A 512
HIS A 519
 None
 0.52A 1uwjA-4xi2A:
7.8		 1uwjA-4xi2A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.46A 1uwjA-4xufA:
27.5		 1uwjA-4xufA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 VAL A 416
ALA A 428
THR A 474
LEU A 512
HIS A 519
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
 0.48A 1uwjA-4y93A:
11.5		 1uwjA-4y93A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 477
ALA A 488
GLU A 509
THR A 539
LEU A 577
 None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
None
 0.37A 1uwjA-4yffA:
26.2		 1uwjA-4yffA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 586
ALA A 597
GLU A 612
CYH A 645
LEU A 679
HIS A 686
 None
 0.67A 1uwjA-4z7gA:
5.2		 1uwjA-4z7gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
None
 0.46A 1uwjA-5a46A:
7.4		 1uwjA-5a46A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
GLU A 290
LEU A 305
THR A 325
LEU A 361
HIS A 377
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
 0.81A 1uwjA-5e8yA:
6.7		 1uwjA-5e8yA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
GLU A 290
LEU A 305
THR A 325
SER A 401
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
 1.12A 1uwjA-5e8yA:
6.7		 1uwjA-5e8yA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 471
ALA A 481
THR A 508
LEU A 514
THR A 529
TRP A 531
CYH A 532
LEU A 567
HIS A 574
GLY A 593
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
None
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
None
5XJ  A 801 ( 3.7A)
 0.55A 1uwjA-5fd2A:
35.4		 1uwjA-5fd2A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 607
ALA A 625
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.59A 1uwjA-5grnA:
7.8		 1uwjA-5grnA:
28.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  30
ALA A  43
THR A  82
LEU A 121
HIS A 131
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-3.7A)
None
None
 0.57A 1uwjA-5hesA:
10.3		 1uwjA-5hesA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1092
ALA A1108
LEU A1140
LEU A1195
HIS A1202
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
None
 0.52A 1uwjA-5horA:
7.4		 1uwjA-5horA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.62A 1uwjA-5j5tA:
21.3		 1uwjA-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 404
ALA A 417
GLU A 436
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 ( 4.7A)
 0.77A 1uwjA-5jznA:
7.1		 1uwjA-5jznA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL B 680
ALA B 690
THR B 739
LEU B 777
HIS B 784
 6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
None
None
 0.48A 1uwjA-5kkrB:
10.1		 1uwjA-5kkrB:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 228
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
 0.93A 1uwjA-5ko1A:
8.6		 1uwjA-5ko1A:
26.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 647
ALA A 663
THR A 711
LEU A 749
HIS A 756
 None
6P6  A1001 (-3.3A)
6P6  A1001 (-3.5A)
None
DIO  A1002 (-4.1A)
 0.51A 1uwjA-5l6oA:
27.6		 1uwjA-5l6oA:
33.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 VAL A 161
ALA A 174
THR A 227
LEU A 264
HIS A 273
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
None
None
GOL  A 604 ( 4.6A)
 0.64A 1uwjA-5o2cA:
9.8		 1uwjA-5o2cA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.66A 1uwjA-5vcxA:
6.9		 1uwjA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 226
ALA A 239
GLU A 259
CYH A 292
HIS A 337
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
8X7  A 501 (-3.8A)
None
None
 0.85A 1uwjA-5vdkA:
21.7		 1uwjA-5vdkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 VAL A  36
ALA A  49
GLU A  69
LEU A  82
LEU A 132
HIS A 141
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
VX6  A 402 ( 4.8A)
None
None
 0.54A 1uwjA-5wnmA:
9.0		 1uwjA-5wnmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 VAL A 899
ALA A 917
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.70A 1uwjA-5wnoA:
8.5		 1uwjA-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 6 VAL A  37
ALA A  50
LEU A 102
THR A 118
HIS A 163
SER A 186
 ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
None
None
 1.02A 1uwjA-5x1tA:
22.7		 1uwjA-5x1tA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 VAL A  94
ALA A 107
GLU A 124
LEU A 203
HIS A 211
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
None
 0.58A 1uwjA-5xv7A:
5.4		 1uwjA-5xv7A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 VAL A 374
ALA A 388
GLU A 409
CYH A 441
LEU A 475
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
None
 0.53A 1uwjA-6c0tA:
7.6		 1uwjA-6c0tA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 VAL A 889
ALA A 906
GLU A 925
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
None
 0.76A 1uwjA-6c7yA:
7.1		 1uwjA-6c7yA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 VAL A 205
ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.64A 1uwjA-6cz4A:
10.7		 1uwjA-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 VAL A 177
ALA A 191
GLU A 208
LEU A 281
HIS A 288
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
 0.56A 1uwjA-6fylA:
22.2		 1uwjA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 424
ILE A  47
ILE A  89
ASP A  44
 None
 0.72A 1uwjA-1ewkA:
undetectable		 1uwjA-1ewkA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  62
LYS A  85
ILE A 109
ILE A 177
 None
 0.73A 1uwjA-1gngA:
8.1		 1uwjA-1gngA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  10
LYS A  33
LEU A  55
ILE A  63
 None
 0.84A 1uwjA-1h4lA:
5.5		 1uwjA-1h4lA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		4 ILE A  88
LEU A 123
ILE A 121
ASP A  48
 None
 0.86A 1uwjA-1hylA:
undetectable		 1uwjA-1hylA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of9 PORE-FORMING PEPTIDE
AMEOBAPORE A

(Entamoeba
histolytica) 		PF03489
(SapB_2) 		4 LEU A  18
ILE A  31
ILE A  58
ASP A  25
 None
 0.64A 1uwjA-1of9A:
undetectable		 1uwjA-1of9A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 ILE A 211
LYS A 232
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.9A)
None
None
 0.60A 1uwjA-1py5A:
6.5		 1uwjA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LYS A 187
LEU A 206
ILE A 225
ILE A 290
 ADP  A 810 (-3.1A)
None
None
None
 0.51A 1uwjA-1q8yA:
5.5		 1uwjA-1q8yA:
24.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 623
LEU A 644
ILE A 653
ASP A 810
 STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
None
STI  A   3 (-3.9A)
 0.55A 1uwjA-1t46A:
28.2		 1uwjA-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvc METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 201
ILE A 214
ILE A 235
ASP A 209
 None
 0.72A 1uwjA-1tvcA:
undetectable		 1uwjA-1tvcA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 ILE A 215
ILE A 327
ILE A 290
ASP A 247
 None
 0.82A 1uwjA-1v5cA:
undetectable		 1uwjA-1v5cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica) 		PF00270
(DEAD) 		4 ILE A 183
LEU A 374
ILE A 242
ILE A 266
 None
 0.83A 1uwjA-1wrbA:
undetectable		 1uwjA-1wrbA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE B 273
LYS B 296
LEU B 312
ILE B 320
 None
 0.81A 1uwjA-2a1aB:
21.9		 1uwjA-2a1aB:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 ILE A 442
LEU A 520
ILE A 427
ASP A 433
 None
 0.83A 1uwjA-2d7dA:
undetectable		 1uwjA-2d7dA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9z PROTEIN KINASE C, NU
TYPE

(Homo sapiens) 		PF00169
(PH) 		4 LEU A  53
ILE A 118
ILE A  51
ASP A  32
 None
 0.81A 1uwjA-2d9zA:
undetectable		 1uwjA-2d9zA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga8 HYPOTHETICAL 39.9
KDA PROTEIN

(Saccharomyces
cerevisiae) 		PF07728
(AAA_5) 		4 ILE A 347
LEU A  44
ILE A 262
ASP A  10
 None
CME  A  45 ( 3.7A)
None
None
 0.86A 1uwjA-2ga8A:
undetectable		 1uwjA-2ga8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  78
LEU A  98
ILE A 107
ILE A 166
 None
 0.74A 1uwjA-2hw6A:
22.3		 1uwjA-2hw6A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 ILE A 428
LYS A 454
ILE A 483
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.7A)
 0.86A 1uwjA-2j0jA:
11.6		 1uwjA-2j0jA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 428
LYS A 454
ILE A 483
ASP A 564
 BII  A1687 (-3.8A)
BII  A1687 (-2.9A)
None
None
 0.75A 1uwjA-2jkmA:
28.1		 1uwjA-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 ILE A  80
LYS A  19
ILE A 188
ASP A 174
 None
ASP  A1234 (-2.9A)
None
ASP  A1234 (-2.8A)
 0.81A 1uwjA-2v25A:
undetectable		 1uwjA-2v25A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 424
LYS A 447
LEU A 463
ILE A 472
 None
 0.67A 1uwjA-2wntA:
19.8		 1uwjA-2wntA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 627
LYS A 653
ILE A 682
ASP A 764
 None
Q9G  A1898 (-4.8A)
None
None
 0.83A 1uwjA-2xyuA:
7.8		 1uwjA-2xyuA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  30
LEU A  81
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.88A 1uwjA-2y7jA:
7.4		 1uwjA-2y7jA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  30
LYS A  53
LEU A  81
ILE A  90
 B49  A1294 (-3.9A)
None
None
None
 0.75A 1uwjA-2y7jA:
7.4		 1uwjA-2y7jA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		4 LYS A  42
LEU A  68
ILE A  76
ILE A 135
 AMP  A1302 (-2.8A)
None
None
None
 0.49A 1uwjA-2yabA:
6.7		 1uwjA-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 123
LEU A 147
ILE A 155
ILE A 214
 STU  A 400 ( 4.3A)
None
None
None
 0.68A 1uwjA-3a62A:
6.8		 1uwjA-3a62A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 LEU A 147
ILE A  70
ILE A  76
PHE A  88
 None
 0.90A 1uwjA-3bxaA:
undetectable		 1uwjA-3bxaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A1028
LEU A1056
ILE A1064
ILE A1124
 ADP  A   1 (-3.0A)
None
None
None
 0.64A 1uwjA-3dlsA:
7.5		 1uwjA-3dlsA:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 150
LYS A 171
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
None
None
None
VIN  A6331 (-4.0A)
 1.07A 1uwjA-3dtcA:
12.8		 1uwjA-3dtcA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS X  69
LEU X  86
ILE X  95
ILE X 153
 CCK  X 351 (-3.5A)
None
None
None
 0.82A 1uwjA-3e3bX:
5.8		 1uwjA-3e3bX:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  32
LYS A  55
LEU A  77
ASP A 169
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.6A)
None
None
 0.75A 1uwjA-3e7oA:
6.5		 1uwjA-3e7oA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  32
LYS A  55
LEU A  77
ILE A  85
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.6A)
None
None
 0.77A 1uwjA-3e7oA:
6.5		 1uwjA-3e7oA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fuy PUTATIVE INTEGRON
GENE CASSETTE
PROTEIN

(uncultured
bacterium) 		no annotation 4 ILE A 122
ILE A  73
ILE A  16
ASP A  46
 None
 0.88A 1uwjA-3fuyA:
undetectable		 1uwjA-3fuyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 209
LYS A 230
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-2.8A)
None
None
 0.70A 1uwjA-3g2fA:
6.5		 1uwjA-3g2fA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  59
LYS A  82
ILE A 112
ASP A 193
 None
 0.78A 1uwjA-3iecA:
6.6		 1uwjA-3iecA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  59
LYS A  82
ILE A 112
ILE A 171
 None
 0.88A 1uwjA-3iecA:
6.6		 1uwjA-3iecA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		4 LEU A  31
ILE A  14
ILE A 129
ASP A 124
 None
 0.85A 1uwjA-3ktoA:
undetectable		 1uwjA-3ktoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)

(Sulfolobus
solfataricus) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		4 LYS A 321
ILE A 262
ILE A 333
ASP A 329
 None
None
SCN  A 366 (-3.5A)
None
 0.81A 1uwjA-3kxiA:
undetectable		 1uwjA-3kxiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A 581
LEU A 600
ILE A 613
ASP A 720
 ANP  A 877 (-2.7A)
None
None
ANP  A 877 (-2.9A)
 0.75A 1uwjA-3lltA:
7.2		 1uwjA-3lltA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		4 ILE A 210
LYS A 231
ILE A 258
ILE A 328
 LDN  A   1 (-4.1A)
None
None
None
 0.83A 1uwjA-3mdyA:
6.6		 1uwjA-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE B1013
LEU A  41
ILE A  73
ILE A 160
 None
 0.78A 1uwjA-3myrB:
undetectable		 1uwjA-3myrB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  51
LEU A  73
ILE A  81
ILE A 140
 ADP  A 314 (-2.8A)
None
None
None
 0.61A 1uwjA-3nizA:
5.8		 1uwjA-3nizA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 4 LEU B 300
ILE B 314
ILE B 329
ASP B 309
 None
 0.83A 1uwjA-3ogkB:
undetectable		 1uwjA-3ogkB:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 355
LYS A 375
LEU A 397
ILE A 405
ILE A 464
 SM5  A   1 (-4.3A)
SM5  A   1 (-3.5A)
None
None
None
 0.71A 1uwjA-3omvA:
13.2		 1uwjA-3omvA:
72.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 LEU A 217
ILE A 140
ILE A 146
PHE A 158
 None
 0.88A 1uwjA-3rwaA:
undetectable		 1uwjA-3rwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN

(Leishmania
major) 		PF00782
(DSPc) 		4 LEU A 127
ILE A 142
ILE A 158
ASP A 137
 None
 0.83A 1uwjA-3s4oA:
undetectable		 1uwjA-3s4oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A 179
LEU A  40
ILE A  79
PHE A 129
 None
 0.89A 1uwjA-3s8dA:
undetectable		 1uwjA-3s8dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 592
ILE A 600
ASP A 697
PHE A 698
 0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.76A 1uwjA-3v5qA:
8.3		 1uwjA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqs LAMININ SUBUNIT
BETA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 ILE A 177
LEU A 227
ILE A 216
ASP A 211
 None
 0.76A 1uwjA-4aqsA:
undetectable		 1uwjA-4aqsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ILE A  66
LEU A  81
ILE A  97
ILE A  51
 None
 0.71A 1uwjA-4ay1A:
undetectable		 1uwjA-4ay1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  61
LYS A  84
LEU A 106
ILE A 114
ASP A 200
 R4L  A1394 (-4.0A)
None
None
None
None
 0.76A 1uwjA-4b99A:
5.5		 1uwjA-4b99A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE

(Drosophila
melanogaster) 		PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		4 ILE A 373
ILE A 427
ILE A 319
ASP A 402
 None
 0.79A 1uwjA-4c0jA:
undetectable		 1uwjA-4c0jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  64
LYS A  90
LEU A 108
ILE A 173
 None
ADP  A 601 (-2.6A)
None
None
 0.88A 1uwjA-4f99A:
5.1		 1uwjA-4f99A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 4 LEU A 138
ILE A  84
ILE A  48
ASP A  81
 None
 0.87A 1uwjA-4fekA:
undetectable		 1uwjA-4fekA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 LEU A 136
ILE A 348
ILE A 302
ASP A 345
 None
 0.72A 1uwjA-4j9vA:
undetectable		 1uwjA-4j9vA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 366
ILE A 133
ILE A 191
ASP A 184
 None
 0.80A 1uwjA-4jr7A:
4.6		 1uwjA-4jr7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LYS A  69
LEU A  86
ILE A 133
ILE A 191
 GNP  A 401 (-3.3A)
None
None
None
 0.61A 1uwjA-4jr7A:
4.6		 1uwjA-4jr7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		4 LEU A  22
ILE A   8
ILE A 127
ASP A   5
 None
 0.89A 1uwjA-4k22A:
undetectable		 1uwjA-4k22A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ILE A 389
LYS A 387
LEU A 457
ASP A 267
 None
 0.74A 1uwjA-4kc8A:
undetectable		 1uwjA-4kc8A:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A  63
LEU A  81
ILE A  89
ASP A 175
 None
None
None
1UL  A 501 (-4.2A)
 0.85A 1uwjA-4l52A:
10.3		 1uwjA-4l52A:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS E  68
LEU E  85
ILE E  94
ILE E 152
 None
 0.62A 1uwjA-4md8E:
4.8		 1uwjA-4md8E:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9x PUTATIVE
MONOOXYGENASE

(Pectobacterium
atrosepticum) 		PF01494
(FAD_binding_3) 		4 LEU A  22
ILE A   8
ILE A 127
ASP A   5
 None
 0.84A 1uwjA-4n9xA:
undetectable		 1uwjA-4n9xA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 ILE B 174
ILE B  56
ILE B  97
PHE B 275
 None
 0.89A 1uwjA-4ouaB:
undetectable		 1uwjA-4ouaB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 ILE A 174
ILE A  56
ILE A  97
PHE A 275
 None
 0.89A 1uwjA-4ouaA:
undetectable		 1uwjA-4ouaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		4 ILE A 131
LEU A 114
ILE A 181
ASP A 175
 None
 0.82A 1uwjA-4p6bA:
undetectable		 1uwjA-4p6bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 ILE A  27
LEU A  74
ILE A  82
ASP A 167
 ANP  A 402 (-4.6A)
None
None
ANP  A 402 ( 2.6A)
 0.84A 1uwjA-4qnyA:
22.2		 1uwjA-4qnyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 ILE A  27
LYS A  51
LEU A  74
ILE A  82
 ANP  A 402 (-4.6A)
ANP  A 402 (-2.8A)
None
None
 0.72A 1uwjA-4qnyA:
22.2		 1uwjA-4qnyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ILE A 642
ILE A 746
ILE A 794
PHE A 682
 None
 0.88A 1uwjA-4rt6A:
undetectable		 1uwjA-4rt6A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		4 LEU A 591
ILE A 191
ASP A 186
PHE A 210
 None
 0.81A 1uwjA-4uirA:
undetectable		 1uwjA-4uirA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 ILE A  29
LEU A  73
ILE A  81
ASP A 165
 42A  A 402 ( 4.7A)
None
None
None
 0.85A 1uwjA-4xrlA:
21.9		 1uwjA-4xrlA:
27.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 469
LYS A 490
LEU A 513
ILE A 584
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.9A)
None
None
 0.75A 1uwjA-4yffA:
26.2		 1uwjA-4yffA:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 165
LYS A 188
LEU A 207
ILE A 221
ILE A 283
 4E1  A 505 ( 4.6A)
4E1  A 505 (-2.7A)
None
None
None
 0.64A 1uwjA-4yljA:
6.5		 1uwjA-4yljA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LYS A  57
LEU A  80
ILE A  88
ILE A 147
 ADP  A 506 (-2.4A)
None
None
None
 0.53A 1uwjA-4ysjA:
7.0		 1uwjA-4ysjA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		4 ILE A 180
ILE A 279
ILE A 236
ASP A 242
 None
 0.83A 1uwjA-5advA:
undetectable		 1uwjA-5advA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 ILE A 328
LEU A 315
ILE A 276
ILE A 303
 None
 0.84A 1uwjA-5c9eA:
undetectable		 1uwjA-5c9eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ILE A  69
LYS A  92
LEU A 114
ILE A 122
ASP A 207
 None
 1.02A 1uwjA-5ci6A:
7.8		 1uwjA-5ci6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clr LEGK4

(Legionella
pneumophila) 		PF00069
(Pkinase) 		4 LEU A  27
ILE A  36
ILE A  72
ASP A  96
 None
 0.87A 1uwjA-5clrA:
15.7		 1uwjA-5clrA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		4 ILE A  42
ILE A  19
ASP A  65
PHE A  66
 None
 0.79A 1uwjA-5dgqA:
undetectable		 1uwjA-5dgqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 LEU A 819
ILE A 790
ILE A 858
ASP A 812
 None
 0.81A 1uwjA-5dmyA:
undetectable		 1uwjA-5dmyA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ILE A 540
LYS A 563
ILE A 594
ASP A 675
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
 0.87A 1uwjA-5ezrA:
10.3		 1uwjA-5ezrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ILE A 540
LYS A 563
ILE A 594
ILE A 653
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
 0.87A 1uwjA-5ezrA:
10.3		 1uwjA-5ezrA:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
LYS A 483
ILE A 513
ILE A 572
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-3.8A)
None
None
 0.59A 1uwjA-5fd2A:
35.4		 1uwjA-5fd2A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 ILE A 169
ILE A  16
ILE A  78
PHE A  58
 None
 0.84A 1uwjA-5fgnA:
undetectable		 1uwjA-5fgnA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu4 CYSTEINE PROTEASE

(Listeria
monocytogenes) 		PF04203
(Sortase) 		4 LEU A  53
ILE A  77
ILE A  68
PHE A 148
 None
 0.89A 1uwjA-5hu4A:
undetectable		 1uwjA-5hu4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 LEU A  49
ILE A 249
ILE A 139
ASP A  56
 None
 0.85A 1uwjA-5infA:
undetectable		 1uwjA-5infA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 276
LYS A 299
ILE A 327
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.5A)
None
None
 0.82A 1uwjA-5kbrA:
7.4		 1uwjA-5kbrA:
30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 155
LYS A 178
LEU A 197
ILE A 271
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.5A)
None
None
 0.78A 1uwjA-5lxdA:
7.6		 1uwjA-5lxdA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1

(Homo sapiens) 		no annotation 4 ILE A  15
LEU A  29
ILE A  43
ILE A  91
 None
None
GOL  A 203 (-4.5A)
None
 0.89A 1uwjA-5onsA:
undetectable		 1uwjA-5onsA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 ILE A 223
LEU A 184
ILE A 135
ILE A 168
 None
None
None
MLY  A 169 ( 3.7A)
 0.81A 1uwjA-5thmA:
undetectable		 1uwjA-5thmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 ILE A  17
LEU A  61
ILE A  69
ASP A 150
 7LV  A 401 (-4.3A)
None
None
7LV  A 401 (-4.2A)
 0.89A 1uwjA-5tvtA:
7.3		 1uwjA-5tvtA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 ILE A  17
LYS A  40
LEU A  61
ILE A  69
 7LV  A 401 (-4.3A)
7LV  A 401 (-3.0A)
None
None
 0.75A 1uwjA-5tvtA:
7.3		 1uwjA-5tvtA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 364
LEU A 288
ILE A 329
PHE A 354
 None
 0.90A 1uwjA-5u7qA:
7.6		 1uwjA-5u7qA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v07 EXONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE Z 125
LEU Z 155
ILE Z  74
PHE Z  77
 None
 0.86A 1uwjA-5v07Z:
undetectable		 1uwjA-5v07Z:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 ILE A 145
LEU A 211
ILE A 389
ILE A 218
 None
 0.74A 1uwjA-5x09A:
undetectable		 1uwjA-5x09A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 4 ILE A 390
LEU A  11
ILE A  34
ILE A  16
 None
 0.85A 1uwjA-5xgwA:
undetectable		 1uwjA-5xgwA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE A  49
LYS A  72
LEU A  89
ILE A  98
ILE A 156
 ATP  A 403 (-4.9A)
ATP  A 403 (-3.2A)
None
None
None
 0.70A 1uwjA-5xvuA:
6.2		 1uwjA-5xvuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 4 ILE A 215
LYS A 238
LEU A 257
ILE A 331
 None
HRM  A 601 (-3.3A)
None
None
 0.80A 1uwjA-5y86A:
6.3		 1uwjA-5y86A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 ILE A 531
LEU A 575
ILE A 585
ASP A 664
 CQ7  A 801 (-3.6A)
None
None
None
 0.79A 1uwjA-6b4wA:
10.7		 1uwjA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 ILE A 531
LYS A 553
LEU A 575
ILE A 585
 CQ7  A 801 (-3.6A)
CQ7  A 801 (-3.2A)
None
None
 0.82A 1uwjA-6b4wA:
10.7		 1uwjA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 4 ILE A 495
ILE A 383
ILE A 467
PHE A 476
 None
 0.88A 1uwjA-6d6vA:
undetectable		 1uwjA-6d6vA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 4 ILE C 165
LYS C 193
ILE C 246
ILE C 330
 None
 0.64A 1uwjA-6eqiC:
8.2		 1uwjA-6eqiC:
24.12