SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWH_B_BAXB1723_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		4 ILE A 264
VAL A 292
VAL A  31
ILE A 371
 None
 0.86A 1uwhB-1a0dA:
0.0		 1uwhB-1a0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A  55
VAL A  82
ILE A  67
ILE A  34
ASP A  72
 None
 1.24A 1uwhB-1a6dA:
0.0		 1uwhB-1a6dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 ILE A1299
VAL A1325
ILE A1032
ASP A1170
 None
 0.85A 1uwhB-1c0iA:
undetectable		 1uwhB-1c0iA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 268
VAL A 189
ILE A 194
ILE A 203
ASP A 238
 None
 1.25A 1uwhB-1e0tA:
undetectable		 1uwhB-1e0tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		4 VAL A 113
VAL A 163
ILE A 140
ILE A  50
 None
 0.81A 1uwhB-1f3gA:
undetectable		 1uwhB-1f3gA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE D 196
VAL D 193
VAL D  68
ILE D 138
ILE D  89
 None
 1.47A 1uwhB-1g0uD:
0.0		 1uwhB-1g0uD:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  62
VAL A  70
ILE A 109
ILE A 177
 None
 0.58A 1uwhB-1gngA:
21.6		 1uwhB-1gngA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC

(Thermotoga
maritima) 		PF03775
(MinC_C) 		4 ILE A  62
VAL A  63
VAL A 122
ILE A 148
 None
 0.79A 1uwhB-1hf2A:
0.3		 1uwhB-1hf2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		4 ILE A 218
VAL A 134
ILE A  59
ILE A  19
 None
 0.81A 1uwhB-1hujA:
0.0		 1uwhB-1hujA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 236
VAL A 239
VAL A 284
ILE A 175
ILE A 286
 None
 1.12A 1uwhB-1hygA:
undetectable		 1uwhB-1hygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Weissella
confusa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 290
VAL A 263
VAL A  50
ILE A  27
 None
 0.76A 1uwhB-1hyhA:
undetectable		 1uwhB-1hyhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE F 220
VAL F 136
ILE F 207
ILE F 168
ASP F 187
 None
 1.37A 1uwhB-1j8mF:
undetectable		 1uwhB-1j8mF:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 VAL A 136
ILE A  57
ILE A  17
ASP A   9
 None
 0.87A 1uwhB-1jfxA:
undetectable		 1uwhB-1jfxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		4 ILE A  71
VAL A  67
VAL A 211
ILE A 124
 None
 0.81A 1uwhB-1jm1A:
undetectable		 1uwhB-1jm1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 205
VAL A 251
ILE A 289
ILE A 168
 None
 0.70A 1uwhB-1k4qA:
undetectable		 1uwhB-1k4qA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 VAL T 251
VAL T  36
ILE T  13
ILE T  72
 None
 0.63A 1uwhB-1lthT:
undetectable		 1uwhB-1lthT:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 720
VAL A1048
ILE A1041
ILE A1056
 None
 0.82A 1uwhB-1ofeA:
undetectable		 1uwhB-1ofeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 283
VAL A 154
VAL A 119
ILE A 109
 None
 0.81A 1uwhB-1pquA:
undetectable		 1uwhB-1pquA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 ILE A 211
VAL A 219
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
None
None
 0.64A 1uwhB-1py5A:
25.5		 1uwhB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 372
VAL A 375
ILE A 227
ILE A  39
 None
 0.77A 1uwhB-1r3nA:
undetectable		 1uwhB-1r3nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 144
VAL A 145
ILE A 426
ASP A 423
 None
 0.83A 1uwhB-1r9jA:
undetectable		 1uwhB-1r9jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3d ARSENATE REDUCTASE

(Escherichia
coli) 		PF03960
(ArsC) 		4 VAL A  55
ILE A  92
ILE A  48
ASP A  83
 None
 0.72A 1uwhB-1s3dA:
undetectable		 1uwhB-1s3dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 ILE A  46
VAL A  47
VAL A  22
ILE A  36
 None
 0.87A 1uwhB-1sivA:
undetectable		 1uwhB-1sivA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 603
VAL A 643
ILE A 653
ASP A 810
 STI  A   3 ( 4.6A)
None
None
STI  A   3 (-3.9A)
 0.69A 1uwhB-1t46A:
18.9		 1uwhB-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 280
VAL A 153
VAL A 118
ILE A 108
 None
 0.79A 1uwhB-1t4bA:
undetectable		 1uwhB-1t4bA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		4 ILE A 110
VAL A 111
ILE A 309
ASP A  92
 None
 0.78A 1uwhB-1u7nA:
undetectable		 1uwhB-1u7nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 ILE A 215
ILE A 327
ILE A 290
ASP A 247
 None
 0.76A 1uwhB-1v5cA:
undetectable		 1uwhB-1v5cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		4 ILE A 111
VAL A 112
ILE A 307
ASP A  93
 None
 0.74A 1uwhB-1vi1A:
undetectable		 1uwhB-1vi1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		4 ILE A 164
VAL A  13
ILE A  51
ILE A   7
 None
 0.87A 1uwhB-1vkmA:
undetectable		 1uwhB-1vkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 ILE A 114
VAL A 274
ILE A 195
ILE A 243
 None
None
NAP  A1330 (-4.2A)
NAP  A1330 (-4.0A)
 0.85A 1uwhB-1w8dA:
undetectable		 1uwhB-1w8dA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 285
ILE A 212
ILE A 154
ASP A 215
 None
None
None
CO  A1003 (-2.8A)
 0.79A 1uwhB-1wn1A:
undetectable		 1uwhB-1wn1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		4 ILE A 356
VAL A 360
ILE A 238
ASP A 313
 None
 0.76A 1uwhB-1x1nA:
undetectable		 1uwhB-1x1nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A   6
ILE A 312
ILE A 131
ASP A 146
 None
 0.75A 1uwhB-1xdiA:
undetectable		 1uwhB-1xdiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 ILE A  11
VAL A   9
ILE A 251
ASP A 244
 None
 0.80A 1uwhB-1xkqA:
undetectable		 1uwhB-1xkqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhB-1yrwA:
undetectable		 1uwhB-1yrwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhB-1z7eA:
undetectable		 1uwhB-1z7eA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		5 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 0.95A 1uwhB-1zdrA:
undetectable		 1uwhB-1zdrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ILE A  85
VAL A  86
ILE A  47
ILE A 164
 None
 0.87A 1uwhB-1zl6A:
undetectable		 1uwhB-1zl6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.94A 1uwhB-1zrzA:
22.6		 1uwhB-1zrzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  33
ILE A 144
ILE A 139
ASP A   8
 None
 0.79A 1uwhB-1zy8A:
undetectable		 1uwhB-1zy8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  70
VAL A  78
ILE A 123
ILE A 185
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
None
None
 0.86A 1uwhB-2b1pA:
4.5		 1uwhB-2b1pA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		5 ILE A 334
VAL A 239
ILE A 312
ILE A  50
ASP A 227
 None
 1.39A 1uwhB-2bznA:
undetectable		 1uwhB-2bznA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb9 FENGYCIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 VAL A  94
ILE A 109
ILE A 160
ASP A 106
 None
 0.83A 1uwhB-2cb9A:
undetectable		 1uwhB-2cb9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 ILE A 384
VAL A 392
VAL A 589
ILE A 665
ILE A 466
 None
 1.41A 1uwhB-2d3iA:
undetectable		 1uwhB-2d3iA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 ILE A 755
VAL A 838
VAL A 742
ILE A 738
 None
 0.83A 1uwhB-2ec5A:
2.6		 1uwhB-2ec5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		5 ILE A 266
VAL A 229
VAL A  90
ILE A  56
ASP A  37
 None
 1.48A 1uwhB-2fk6A:
undetectable		 1uwhB-2fk6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 ILE A  84
VAL A 462
ILE A  98
ILE A 387
 None
 0.81A 1uwhB-2ftwA:
undetectable		 1uwhB-2ftwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		4 ILE A 287
VAL A 282
VAL A 101
ILE A 157
 None
 0.87A 1uwhB-2gp4A:
undetectable		 1uwhB-2gp4A:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 823
ILE A 884
ILE A 738
ASP A 816
 None
 0.83A 1uwhB-2henA:
28.3		 1uwhB-2henA:
32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		4 ILE A 134
VAL A 130
ILE A  87
ILE A  52
 None
 0.75A 1uwhB-2hj0A:
undetectable		 1uwhB-2hj0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 333
ILE A 107
ILE A 166
ASP A 159
 None
 0.86A 1uwhB-2hw6A:
22.4		 1uwhB-2hw6A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 428
VAL A 436
ILE A 483
ASP A 564
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
None
None
 0.67A 1uwhB-2jkmA:
16.1		 1uwhB-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0t SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF00790
(VHS) 		4 ILE B 104
VAL B 103
VAL B  20
ILE B  39
 None
 0.80A 1uwhB-2l0tB:
undetectable		 1uwhB-2l0tB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A 278
VAL A 197
ILE A 184
ASP A 163
 None
 0.78A 1uwhB-2og2A:
undetectable		 1uwhB-2og2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 ILE A 266
VAL A 263
VAL A 194
ILE A 135
 None
 0.85A 1uwhB-2pbgA:
undetectable		 1uwhB-2pbgA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 VAL A  51
VAL A 142
ILE A  66
ILE A 198
ASP A 204
 None
 1.44A 1uwhB-2pbyA:
undetectable		 1uwhB-2pbyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe9 UNCHARACTERIZED
PROTEIN YIZA

(Bacillus
subtilis) 		PF05163
(DinB) 		4 VAL A  35
ILE A 121
ILE A  86
ASP A  47
 CIT  A 201 (-4.7A)
None
None
None
 0.86A 1uwhB-2qe9A:
undetectable		 1uwhB-2qe9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4

(Phytolacca
dioica) 		PF00161
(RIP) 		4 VAL A 154
VAL A   8
ILE A 141
ASP A 147
 None
 0.87A 1uwhB-2qesA:
undetectable		 1uwhB-2qesA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 813
ILE A 874
ILE A 730
ASP A 806
 None
 0.78A 1uwhB-2qobA:
28.4		 1uwhB-2qobA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		5 ILE A 165
VAL A 164
VAL A 273
ILE A 240
ASP A 264
 None
 1.42A 1uwhB-2qr6A:
undetectable		 1uwhB-2qr6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxt LIPASE

(Bacillus
subtilis) 		PF01674
(Lipase_2) 		4 ILE A 135
VAL A 136
ILE A  73
ILE A  87
 None
 0.85A 1uwhB-2qxtA:
undetectable		 1uwhB-2qxtA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ILE A 681
VAL A 689
ILE A 736
ASP A 818
 None
 0.71A 1uwhB-2r2pA:
28.4		 1uwhB-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 867
ILE A 928
ILE A 784
ASP A 860
 None
 0.77A 1uwhB-2r2pA:
28.4		 1uwhB-2r2pA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 713
VAL A1013
ILE A1006
ILE A1021
 None
 0.78A 1uwhB-2vdcA:
undetectable		 1uwhB-2vdcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 716
VAL A 715
VAL A 294
ILE A 532
 None
 0.87A 1uwhB-2vdcA:
undetectable		 1uwhB-2vdcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		4 ILE A 270
VAL A 253
VAL A 142
ILE A 173
 None
 0.87A 1uwhB-2w38A:
undetectable		 1uwhB-2w38A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4l DEOXYCYTIDYLATE
DEAMINASE

(Homo sapiens) 		PF00383
(dCMP_cyt_deam_1) 		4 ILE A 162
VAL A 125
ILE A  41
ILE A 117
 ILE  A 162 ( 0.6A)
VAL  A 125 ( 0.6A)
ILE  A  41 ( 0.7A)
ILE  A 117 ( 0.7A)
 0.86A 1uwhB-2w4lA:
undetectable		 1uwhB-2w4lA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE B  75
VAL B  85
VAL B 121
ILE B 130
 ANP  B 432 (-4.4A)
ANP  B 432 (-4.6A)
None
None
 0.79A 1uwhB-2wtkB:
23.4		 1uwhB-2wtkB:
27.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 627
VAL A 635
ILE A 682
ASP A 764
 None
Q9G  A1898 ( 4.7A)
None
None
 0.66A 1uwhB-2xyuA:
29.1		 1uwhB-2xyuA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 813
ILE A 874
ILE A 730
ASP A 806
 None
 0.83A 1uwhB-2xyuA:
29.1		 1uwhB-2xyuA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  30
VAL A  38
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.74A 1uwhB-2y7jA:
15.7		 1uwhB-2y7jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 VAL A  27
ILE A 176
ILE A  23
ASP A 152
 None
 0.75A 1uwhB-2y9xA:
undetectable		 1uwhB-2y9xA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 ILE A 124
VAL A 125
ILE A 298
ASP A 234
 None
 0.85A 1uwhB-2zamA:
undetectable		 1uwhB-2zamA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ILE A 216
VAL A 278
ILE A 194
ILE A 430
 None
 0.86A 1uwhB-2zr2A:
undetectable		 1uwhB-2zr2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9i HOMOCITRATE SYNTHASE

(Thermus
thermophilus) 		PF00682
(HMGL-like) 		4 ILE A  42
VAL A 158
ILE A 123
ASP A  92
 None
None
None
LYS  A 378 (-3.3A)
 0.82A 1uwhB-3a9iA:
undetectable		 1uwhB-3a9iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9i HOMOCITRATE SYNTHASE

(Thermus
thermophilus) 		PF00682
(HMGL-like) 		4 ILE A 231
VAL A 158
ILE A  91
ILE A 120
 None
 0.81A 1uwhB-3a9iA:
undetectable		 1uwhB-3a9iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  18
VAL A  26
ILE A  74
ILE A 137
 3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
None
None
 0.81A 1uwhB-3c0iA:
24.6		 1uwhB-3c0iA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 ILE A 784
VAL A 721
ILE A 728
ILE A 674
 None
 0.82A 1uwhB-3c2gA:
undetectable		 1uwhB-3c2gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A 186
VAL A 183
VAL A  73
ILE A  82
ILE A  10
 None
 1.41A 1uwhB-3db2A:
undetectable		 1uwhB-3db2A:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 825
ILE A 886
ILE A 742
ASP A 818
 None
 0.75A 1uwhB-3dkoA:
28.2		 1uwhB-3dkoA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 150
VAL A 158
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
None
None
VIN  A6331 (-4.0A)
 0.80A 1uwhB-3dtcA:
27.2		 1uwhB-3dtcA:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ILE A  73
VAL A 210
ILE A  91
ILE A 121
 None
 0.81A 1uwhB-3e77A:
undetectable		 1uwhB-3e77A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  32
VAL A  40
ILE A  85
ILE A 147
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
None
None
 0.75A 1uwhB-3e7oA:
20.5		 1uwhB-3e7oA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A  34
VAL A  42
ILE A  85
ASP A 169
 DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
None
None
 0.74A 1uwhB-3f3zA:
8.7		 1uwhB-3f3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ILE A 133
VAL A 150
ILE A  84
ILE A  50
 None
 0.80A 1uwhB-3f9kA:
undetectable		 1uwhB-3f9kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  62
VAL A  70
ILE A 115
ILE A 174
 None
 0.66A 1uwhB-3fe3A:
23.2		 1uwhB-3fe3A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		5 ILE A 239
VAL A 252
VAL A  60
ILE A 162
ASP A  55
 None
 1.35A 1uwhB-3fqdA:
undetectable		 1uwhB-3fqdA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 209
VAL A 217
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
None
None
 0.66A 1uwhB-3g2fA:
24.8		 1uwhB-3g2fA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		4 ILE A 102
VAL A  80
VAL A 240
ILE A 161
 None
None
None
EDO  A 255 (-4.5A)
 0.71A 1uwhB-3ggdA:
undetectable		 1uwhB-3ggdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 VAL A 389
ILE A 403
ILE A 360
ASP A 370
 None
 0.86A 1uwhB-3h09A:
undetectable		 1uwhB-3h09A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		4 ILE A 100
VAL A 130
ILE A  66
ILE A  84
 None
 0.86A 1uwhB-3h5lA:
undetectable		 1uwhB-3h5lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		5 ILE A 125
VAL A 124
ILE A  42
ILE A  85
ASP A  94
 None
 1.45A 1uwhB-3hh8A:
undetectable		 1uwhB-3hh8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn6 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Borreliella
burgdorferi) 		PF01182
(Glucosamine_iso) 		4 ILE A   4
VAL A 238
ILE A  61
ILE A  97
 None
 0.85A 1uwhB-3hn6A:
undetectable		 1uwhB-3hn6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		4 ILE A 964
VAL A 938
VAL A 804
ILE A 820
 None
 0.81A 1uwhB-3hx6A:
undetectable		 1uwhB-3hx6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00579
(tRNA-synt_1b) 		4 ILE A 168
VAL A 165
ILE A 110
ILE A 136
 None
 0.80A 1uwhB-3i05A:
undetectable		 1uwhB-3i05A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4s HISTIDINE TRIAD
PROTEIN

(Bradyrhizobium
japonicum) 		PF01230
(HIT) 		4 VAL A 144
VAL A 101
ILE A 108
ILE A 169
 None
 0.70A 1uwhB-3i4sA:
3.0		 1uwhB-3i4sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 209
VAL A 217
ILE A 244
ILE A 123
 None
 0.69A 1uwhB-3icsA:
undetectable		 1uwhB-3icsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A  59
VAL A  67
ILE A 112
ILE A 171
ASP A 193
 None
 0.90A 1uwhB-3iecA:
23.5		 1uwhB-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jte RESPONSE REGULATOR
RECEIVER PROTEIN

(Ruminiclostridium
thermocellum) 		PF00072
(Response_reg) 		4 ILE A  25
VAL A  80
ILE A  50
ILE A  71
 None
 0.87A 1uwhB-3jteA:
undetectable		 1uwhB-3jteA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		4 VAL A 130
ILE A 221
ILE A 214
ASP A 194
 None
 0.72A 1uwhB-3k6rA:
undetectable		 1uwhB-3k6rA:
20.92