SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWH_B_BAXB1723

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
GLU A  51
LEU A  55
CYH A  83
HIS A 124
 None
 0.80A 1uwhB-1h4lA:
14.6		 1uwhB-1h4lA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.54A 1uwhB-1k9aA:
27.7		 1uwhB-1k9aA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
 0.53A 1uwhB-1opkA:
26.5		 1uwhB-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 230
LYS A 232
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.56A 1uwhB-1py5A:
25.5		 1uwhB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A 185
LYS A 187
GLU A 202
LEU A 206
LEU A 226
HIS A 292
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
None
 0.73A 1uwhB-1q8yA:
20.7		 1uwhB-1q8yA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
 0.72A 1uwhB-1rjbA:
27.8		 1uwhB-1rjbA:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
CYH A 673
LEU A 783
HIS A 790
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
 0.59A 1uwhB-1t46A:
18.9		 1uwhB-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ALA A  55
LYS A  57
GLU A  76
LEU A  80
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.72A 1uwhB-1u5qA:
24.7		 1uwhB-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
None
None
 0.64A 1uwhB-1zltA:
8.5		 1uwhB-1zltA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
 0.65A 1uwhB-1zwsA:
24.1		 1uwhB-1zwsA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 GOL  A3001 (-3.5A)
None
None
None
None
None
 0.52A 1uwhB-2a2aA:
23.9		 1uwhB-2a2aA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
LYS A 186
GLU A 201
LEU A 205
LEU A 274
HIS A 281
 None
 0.69A 1uwhB-2eu9A:
22.6		 1uwhB-2eu9A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.0A)
None
None
None
 0.78A 1uwhB-2gcdA:
25.6		 1uwhB-2gcdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
LEU A  80
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
None
None
None
None
 0.90A 1uwhB-2gcdA:
25.6		 1uwhB-2gcdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
LYS A 271
GLU A 286
THR A 315
LEU A 354
HIS A 361
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
 0.68A 1uwhB-2hz0A:
28.3		 1uwhB-2hz0A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.57A 1uwhB-2j0jA:
29.1		 1uwhB-2j0jA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
BII  A1687 (-4.1A)
None
None
BII  A1687 ( 3.9A)
 0.71A 1uwhB-2jkmA:
16.1		 1uwhB-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
THR A 663
CYH A 666
LEU A 769
HIS A 776
GLY A 795
 None
 0.51A 1uwhB-2ogvA:
27.5		 1uwhB-2ogvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
LYS A 616
GLU A 633
LEU A 769
HIS A 776
GLY A 795
 None
 0.71A 1uwhB-2ogvA:
27.5		 1uwhB-2ogvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
LYS A 217
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.82A 1uwhB-2qluA:
25.1		 1uwhB-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 449
LYS A 451
GLU A 463
LEU A 467
THR A 493
LEU A 530
HIS A 537
 None
 0.63A 1uwhB-2qr7A:
20.4		 1uwhB-2qr7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
 0.51A 1uwhB-2w4kA:
23.8		 1uwhB-2w4kA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LYS A 447
GLU A 459
LEU A 463
THR A 489
LEU A 526
HIS A 533
 None
 0.81A 1uwhB-2wntA:
20.2		 1uwhB-2wntA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA C  76
LYS C  78
LEU C 102
CYH C 132
LEU C 167
HIS C 174
 ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
None
None
 0.68A 1uwhB-2wtkC:
23.5		 1uwhB-2wtkC:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
None
 0.48A 1uwhB-2yabA:
23.8		 1uwhB-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
None
None
 0.60A 1uwhB-3bqrA:
22.4		 1uwhB-3bqrA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.54A 1uwhB-3d7uA:
19.2		 1uwhB-3d7uA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  51
LYS A  53
GLU A  71
LEU A  75
THR A 106
HIS A 148
 NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
 0.67A 1uwhB-3gp0A:
22.5		 1uwhB-3gp0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
LYS A 861
GLU A 878
LEU A 882
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.50A 1uwhB-3hngA:
29.2		 1uwhB-3hngA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
LYS A 667
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.60A 1uwhB-3kulA:
19.4		 1uwhB-3kulA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 ALA A 700
LYS A 702
GLU A 715
LEU A 719
CYH A 748
LEU A 788
HIS A 795
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
ADP  A2101 (-4.2A)
None
None
 0.66A 1uwhB-3lj0A:
23.3		 1uwhB-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA A 579
LYS A 581
GLU A 596
LEU A 600
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.71A 1uwhB-3lltA:
21.2		 1uwhB-3lltA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ALA A 229
LYS A 231
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
None
 0.63A 1uwhB-3mdyA:
24.7		 1uwhB-3mdyA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  46
LYS A  48
GLU A  66
LEU A  70
CYH A 106
HIS A 147
 None
 0.61A 1uwhB-3mi9A:
14.4		 1uwhB-3mi9A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
LYS A 229
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
None
 0.63A 1uwhB-3my0A:
24.9		 1uwhB-3my0A:
27.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 373
LYS A 375
GLU A 393
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
 0.95A 1uwhB-3omvA:
36.3		 1uwhB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 373
LYS A 375
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
 0.81A 1uwhB-3omvA:
36.3		 1uwhB-3omvA:
72.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		6 ALA A  49
LEU A  82
LEU A  91
THR A 112
LEU A 149
HIS A 156
 None
 0.73A 1uwhB-3pg1A:
14.5		 1uwhB-3pg1A:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
LYS A 578
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
None
 0.60A 1uwhB-3ppzA:
29.1		 1uwhB-3ppzA:
39.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 217
LYS A 219
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.93A 1uwhB-3q4tA:
25.2		 1uwhB-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
None
 0.72A 1uwhB-3q5iA:
21.4		 1uwhB-3q5iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA B 616
LYS B 618
GLU B 635
LEU B 639
CYH B 889
HIS B 933
GLY B 952
 None
 0.76A 1uwhB-3qd2B:
21.7		 1uwhB-3qd2B:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 368
GLU A 384
LEU A 397
THR A 413
LEU A 451
HIS A 458
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-4.6A)
STU  A   1 (-3.9A)
None
None
 0.70A 1uwhB-3s95A:
26.1		 1uwhB-3s95A:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
None
None
 0.65A 1uwhB-3vidA:
27.4		 1uwhB-3vidA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
 4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
None
 0.62A 1uwhB-3vidA:
27.4		 1uwhB-3vidA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
None
 0.61A 1uwhB-3wzdA:
27.4		 1uwhB-3wzdA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
 LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
 0.68A 1uwhB-3wzdA:
27.4		 1uwhB-3wzdA:
29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1978
LYS A1980
LEU A2010
LEU A2070
HIS A2077
GLY A2101
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
 0.80A 1uwhB-3zbfA:
19.0		 1uwhB-3zbfA:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
GLU A  50
LEU A  54
LEU A 116
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
None
 0.81A 1uwhB-3zduA:
22.9		 1uwhB-3zduA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 649
LYS A 651
GLU A 668
THR A 697
LEU A 735
HIS A 742
 None
 0.81A 1uwhB-3zfxA:
28.9		 1uwhB-3zfxA:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  80
LYS A  82
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwhB-4a4lA:
24.3		 1uwhB-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.2A)
None
None
 0.70A 1uwhB-4agdA:
28.4		 1uwhB-4agdA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
GLU A  51
LEU A  55
CYH A  83
HIS A 124
 D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
D15  A 500 (-4.3A)
None
 0.46A 1uwhB-4aguA:
24.6		 1uwhB-4aguA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  89
LYS A  91
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.60A 1uwhB-4b6lA:
24.3		 1uwhB-4b6lA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
GLU A  81
LEU A  85
CYH A 113
LEU A 148
HIS A 155
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-3.7A)
None
None
 0.67A 1uwhB-4bc6A:
22.1		 1uwhB-4bc6A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
LYS A 235
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.58A 1uwhB-4c02A:
24.7		 1uwhB-4c02A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
LYS A 655
GLU A 672
THR A 701
LEU A 757
HIS A 764
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
 0.59A 1uwhB-4ckrA:
28.4		 1uwhB-4ckrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  42
LYS A  44
GLU A  61
CYH A  99
LEU A 136
HIS A 143
 None
 0.70A 1uwhB-4e3cA:
18.8		 1uwhB-4e3cA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.70A 1uwhB-4eutA:
20.5		 1uwhB-4eutA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.66A 1uwhB-4euuA:
13.8		 1uwhB-4euuA:
25.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 880
LYS A 882
GLU A 898
LEU A 902
LEU A 967
HIS A 974
GLY A 993
 IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
None
None
 0.93A 1uwhB-4gl9A:
26.0		 1uwhB-4gl9A:
30.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
LYS A 855
GLU A 871
LEU A 875
LEU A 940
HIS A 947
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
None
 0.64A 1uwhB-4hviA:
27.0		 1uwhB-4hviA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 ALA A 156
LYS A 158
THR A 205
LEU A 243
HIS A 250
GLY A 269
 None
 0.73A 1uwhB-4hzsA:
25.9		 1uwhB-4hzsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.66A 1uwhB-4i6fA:
23.1		 1uwhB-4i6fA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 ALA A  66
LYS A  68
GLU A  87
CYH A 119
LEU A 153
HIS A 160
GLY A 179
 None
 0.83A 1uwhB-4j7bA:
24.3		 1uwhB-4j7bA:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A  61
LYS A  63
GLU A  77
LEU A  81
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
None
None
None
None
 0.73A 1uwhB-4l52A:
27.1		 1uwhB-4l52A:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
LYS A  51
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
None
 0.74A 1uwhB-4m69A:
25.8		 1uwhB-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  99
LYS A 101
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.2A)
None
None
 0.76A 1uwhB-4mvfA:
20.9		 1uwhB-4mvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ALA A 388
LYS A 390
LEU A 406
CYH A 435
LEU A 473
HIS A 480
 None
 0.81A 1uwhB-4o1oA:
15.9		 1uwhB-4o1oA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA B  51
LYS B  53
GLU B  70
LEU B  74
LEU B 135
HIS B 142
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
 0.58A 1uwhB-4o27B:
15.6		 1uwhB-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
None
 0.68A 1uwhB-4o38A:
21.0		 1uwhB-4o38A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ALA B 390
LYS B 392
LEU B 408
CYH B 437
LEU B 475
HIS B 483
 ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
None
ACP  B 801 (-4.5A)
None
None
 0.79A 1uwhB-4oavB:
17.1		 1uwhB-4oavB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 928
LYS A 930
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 2TT  A1202 ( 3.9A)
None
None
None
None
None
2TT  A1202 (-3.4A)
 0.95A 1uwhB-4oliA:
26.3		 1uwhB-4oliA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.45A 1uwhB-4rt7A:
18.7		 1uwhB-4rt7A:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
LYS A  37
GLU A  52
THR A  81
LEU A 120
HIS A 127
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 0.83A 1uwhB-4ueuA:
28.4		 1uwhB-4ueuA:
36.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.59A 1uwhB-4xufA:
28.4		 1uwhB-4xufA:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 488
LYS A 490
GLU A 509
LEU A 513
THR A 539
LEU A 577
HIS A 586
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
None
None
 0.64A 1uwhB-4yffA:
17.2		 1uwhB-4yffA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
 0.64A 1uwhB-4ysjA:
24.3		 1uwhB-4ysjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 597
GLU A 612
LEU A 616
CYH A 645
LEU A 679
HIS A 686
 None
 0.68A 1uwhB-4z7gA:
20.8		 1uwhB-4z7gA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
GLU A 290
LEU A 305
THR A 325
LEU A 361
HIS A 377
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
 0.80A 1uwhB-5e8yA:
24.8		 1uwhB-5e8yA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 928
LYS A 930
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 5U3  A1200 (-3.5A)
None
None
None
None
None
5U3  A1200 ( 4.9A)
 0.96A 1uwhB-5f1zA:
25.8		 1uwhB-5f1zA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
CYH A 532
LEU A 567
HIS A 574
GLY A 593
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
None
5XJ  A 801 ( 3.7A)
 0.54A 1uwhB-5fd2A:
36.4		 1uwhB-5fd2A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 756
LYS A 758
GLU A 775
LEU A 779
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
None
 0.80A 1uwhB-5fm2A:
27.4		 1uwhB-5fm2A:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.52A 1uwhB-5grnA:
18.5		 1uwhB-5grnA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  50
LYS A  52
GLU A  66
LEU A  70
LEU A 142
HIS A 149
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
None
None
FMT  A 403 (-4.6A)
 0.81A 1uwhB-5idnA:
12.1		 1uwhB-5idnA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
LYS A  45
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
None
None
 0.53A 1uwhB-5j5tA:
21.5		 1uwhB-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.82A 1uwhB-5jznA:
23.6		 1uwhB-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 228
LYS A 230
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
 0.88A 1uwhB-5ko1A:
26.8		 1uwhB-5ko1A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 176
LYS A 178
GLU A 193
LEU A 197
LEU A 266
HIS A 273
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
None
None
 0.84A 1uwhB-5lxdA:
20.4		 1uwhB-5lxdA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 119
LYS A 121
GLU A 136
LEU A 140
LEU A 215
HIS A 223
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
 0.75A 1uwhB-5myvA:
19.7		 1uwhB-5myvA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 6 ALA A  38
LYS A  40
GLU A  57
LEU A  61
CYH A  89
HIS A 130
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.3A)
None
 0.71A 1uwhB-5tvtA:
23.6		 1uwhB-5tvtA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.65A 1uwhB-5vcxA:
22.6		 1uwhB-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 ALA A 917
LYS A 919
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.78A 1uwhB-5wnoA:
25.0		 1uwhB-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 ALA A 107
LYS A 109
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
 0.69A 1uwhB-5xv7A:
20.9		 1uwhB-5xv7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 ALA A 236
LYS A 238
GLU A 253
LEU A 257
LEU A 326
HIS A 333
 HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.6A)
None
None
None
 0.78A 1uwhB-5y86A:
20.5		 1uwhB-5y86A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ALA A 906
LYS A 908
GLU A 925
LEU A 929
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
None
 0.85A 1uwhB-6c7yA:
25.7		 1uwhB-6c7yA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 7 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.75A 1uwhB-6cnhA:
21.7		 1uwhB-6cnhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.50A 1uwhB-6cz4A:
26.8		 1uwhB-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 ALA A 191
LYS A 193
GLU A 208
LEU A 212
LEU A 281
HIS A 288
 3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
 0.59A 1uwhB-6fylA:
22.4		 1uwhB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 ALA A 189
LYS A 191
GLU A 206
LEU A 210
LEU A 279
HIS A 286
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.67A 1uwhB-6fyvA:
22.4		 1uwhB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		4 ILE A 264
VAL A 292
VAL A  31
ILE A 371
 None
 0.86A 1uwhB-1a0dA:
0.0		 1uwhB-1a0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A  55
VAL A  82
ILE A  67
ILE A  34
ASP A  72
 None
 1.24A 1uwhB-1a6dA:
0.0		 1uwhB-1a6dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 ILE A1299
VAL A1325
ILE A1032
ASP A1170
 None
 0.85A 1uwhB-1c0iA:
undetectable		 1uwhB-1c0iA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 268
VAL A 189
ILE A 194
ILE A 203
ASP A 238
 None
 1.25A 1uwhB-1e0tA:
undetectable		 1uwhB-1e0tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		4 VAL A 113
VAL A 163
ILE A 140
ILE A  50
 None
 0.81A 1uwhB-1f3gA:
undetectable		 1uwhB-1f3gA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE D 196
VAL D 193
VAL D  68
ILE D 138
ILE D  89
 None
 1.47A 1uwhB-1g0uD:
0.0		 1uwhB-1g0uD:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  62
VAL A  70
ILE A 109
ILE A 177
 None
 0.58A 1uwhB-1gngA:
21.6		 1uwhB-1gngA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC

(Thermotoga
maritima) 		PF03775
(MinC_C) 		4 ILE A  62
VAL A  63
VAL A 122
ILE A 148
 None
 0.79A 1uwhB-1hf2A:
0.3		 1uwhB-1hf2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		4 ILE A 218
VAL A 134
ILE A  59
ILE A  19
 None
 0.81A 1uwhB-1hujA:
0.0		 1uwhB-1hujA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 236
VAL A 239
VAL A 284
ILE A 175
ILE A 286
 None
 1.12A 1uwhB-1hygA:
undetectable		 1uwhB-1hygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Weissella
confusa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 290
VAL A 263
VAL A  50
ILE A  27
 None
 0.76A 1uwhB-1hyhA:
undetectable		 1uwhB-1hyhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE F 220
VAL F 136
ILE F 207
ILE F 168
ASP F 187
 None
 1.37A 1uwhB-1j8mF:
undetectable		 1uwhB-1j8mF:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 VAL A 136
ILE A  57
ILE A  17
ASP A   9
 None
 0.87A 1uwhB-1jfxA:
undetectable		 1uwhB-1jfxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		4 ILE A  71
VAL A  67
VAL A 211
ILE A 124
 None
 0.81A 1uwhB-1jm1A:
undetectable		 1uwhB-1jm1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 205
VAL A 251
ILE A 289
ILE A 168
 None
 0.70A 1uwhB-1k4qA:
undetectable		 1uwhB-1k4qA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 VAL T 251
VAL T  36
ILE T  13
ILE T  72
 None
 0.63A 1uwhB-1lthT:
undetectable		 1uwhB-1lthT:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 720
VAL A1048
ILE A1041
ILE A1056
 None
 0.82A 1uwhB-1ofeA:
undetectable		 1uwhB-1ofeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 283
VAL A 154
VAL A 119
ILE A 109
 None
 0.81A 1uwhB-1pquA:
undetectable		 1uwhB-1pquA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 ILE A 211
VAL A 219
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
None
None
 0.64A 1uwhB-1py5A:
25.5		 1uwhB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 372
VAL A 375
ILE A 227
ILE A  39
 None
 0.77A 1uwhB-1r3nA:
undetectable		 1uwhB-1r3nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 144
VAL A 145
ILE A 426
ASP A 423
 None
 0.83A 1uwhB-1r9jA:
undetectable		 1uwhB-1r9jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3d ARSENATE REDUCTASE

(Escherichia
coli) 		PF03960
(ArsC) 		4 VAL A  55
ILE A  92
ILE A  48
ASP A  83
 None
 0.72A 1uwhB-1s3dA:
undetectable		 1uwhB-1s3dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 ILE A  46
VAL A  47
VAL A  22
ILE A  36
 None
 0.87A 1uwhB-1sivA:
undetectable		 1uwhB-1sivA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 603
VAL A 643
ILE A 653
ASP A 810
 STI  A   3 ( 4.6A)
None
None
STI  A   3 (-3.9A)
 0.69A 1uwhB-1t46A:
18.9		 1uwhB-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 280
VAL A 153
VAL A 118
ILE A 108
 None
 0.79A 1uwhB-1t4bA:
undetectable		 1uwhB-1t4bA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		4 ILE A 110
VAL A 111
ILE A 309
ASP A  92
 None
 0.78A 1uwhB-1u7nA:
undetectable		 1uwhB-1u7nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 ILE A 215
ILE A 327
ILE A 290
ASP A 247
 None
 0.76A 1uwhB-1v5cA:
undetectable		 1uwhB-1v5cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		4 ILE A 111
VAL A 112
ILE A 307
ASP A  93
 None
 0.74A 1uwhB-1vi1A:
undetectable		 1uwhB-1vi1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		4 ILE A 164
VAL A  13
ILE A  51
ILE A   7
 None
 0.87A 1uwhB-1vkmA:
undetectable		 1uwhB-1vkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 ILE A 114
VAL A 274
ILE A 195
ILE A 243
 None
None
NAP  A1330 (-4.2A)
NAP  A1330 (-4.0A)
 0.85A 1uwhB-1w8dA:
undetectable		 1uwhB-1w8dA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 285
ILE A 212
ILE A 154
ASP A 215
 None
None
None
CO  A1003 (-2.8A)
 0.79A 1uwhB-1wn1A:
undetectable		 1uwhB-1wn1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		4 ILE A 356
VAL A 360
ILE A 238
ASP A 313
 None
 0.76A 1uwhB-1x1nA:
undetectable		 1uwhB-1x1nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A   6
ILE A 312
ILE A 131
ASP A 146
 None
 0.75A 1uwhB-1xdiA:
undetectable		 1uwhB-1xdiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 ILE A  11
VAL A   9
ILE A 251
ASP A 244
 None
 0.80A 1uwhB-1xkqA:
undetectable		 1uwhB-1xkqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhB-1yrwA:
undetectable		 1uwhB-1yrwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhB-1z7eA:
undetectable		 1uwhB-1z7eA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		5 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 0.95A 1uwhB-1zdrA:
undetectable		 1uwhB-1zdrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ILE A  85
VAL A  86
ILE A  47
ILE A 164
 None
 0.87A 1uwhB-1zl6A:
undetectable		 1uwhB-1zl6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.94A 1uwhB-1zrzA:
22.6		 1uwhB-1zrzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  33
ILE A 144
ILE A 139
ASP A   8
 None
 0.79A 1uwhB-1zy8A:
undetectable		 1uwhB-1zy8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  70
VAL A  78
ILE A 123
ILE A 185
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
None
None
 0.86A 1uwhB-2b1pA:
4.5		 1uwhB-2b1pA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		5 ILE A 334
VAL A 239
ILE A 312
ILE A  50
ASP A 227
 None
 1.39A 1uwhB-2bznA:
undetectable		 1uwhB-2bznA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb9 FENGYCIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 VAL A  94
ILE A 109
ILE A 160
ASP A 106
 None
 0.83A 1uwhB-2cb9A:
undetectable		 1uwhB-2cb9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 ILE A 384
VAL A 392
VAL A 589
ILE A 665
ILE A 466
 None
 1.41A 1uwhB-2d3iA:
undetectable		 1uwhB-2d3iA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 ILE A 755
VAL A 838
VAL A 742
ILE A 738
 None
 0.83A 1uwhB-2ec5A:
2.6		 1uwhB-2ec5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		5 ILE A 266
VAL A 229
VAL A  90
ILE A  56
ASP A  37
 None
 1.48A 1uwhB-2fk6A:
undetectable		 1uwhB-2fk6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 ILE A  84
VAL A 462
ILE A  98
ILE A 387
 None
 0.81A 1uwhB-2ftwA:
undetectable		 1uwhB-2ftwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		4 ILE A 287
VAL A 282
VAL A 101
ILE A 157
 None
 0.87A 1uwhB-2gp4A:
undetectable		 1uwhB-2gp4A:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 823
ILE A 884
ILE A 738
ASP A 816
 None
 0.83A 1uwhB-2henA:
28.3		 1uwhB-2henA:
32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		4 ILE A 134
VAL A 130
ILE A  87
ILE A  52
 None
 0.75A 1uwhB-2hj0A:
undetectable		 1uwhB-2hj0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 333
ILE A 107
ILE A 166
ASP A 159
 None
 0.86A 1uwhB-2hw6A:
22.4		 1uwhB-2hw6A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 428
VAL A 436
ILE A 483
ASP A 564
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
None
None
 0.67A 1uwhB-2jkmA:
16.1		 1uwhB-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0t SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF00790
(VHS) 		4 ILE B 104
VAL B 103
VAL B  20
ILE B  39
 None
 0.80A 1uwhB-2l0tB:
undetectable		 1uwhB-2l0tB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A 278
VAL A 197
ILE A 184
ASP A 163
 None
 0.78A 1uwhB-2og2A:
undetectable		 1uwhB-2og2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 ILE A 266
VAL A 263
VAL A 194
ILE A 135
 None
 0.85A 1uwhB-2pbgA:
undetectable		 1uwhB-2pbgA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 VAL A  51
VAL A 142
ILE A  66
ILE A 198
ASP A 204
 None
 1.44A 1uwhB-2pbyA:
undetectable		 1uwhB-2pbyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe9 UNCHARACTERIZED
PROTEIN YIZA

(Bacillus
subtilis) 		PF05163
(DinB) 		4 VAL A  35
ILE A 121
ILE A  86
ASP A  47
 CIT  A 201 (-4.7A)
None
None
None
 0.86A 1uwhB-2qe9A:
undetectable		 1uwhB-2qe9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4

(Phytolacca
dioica) 		PF00161
(RIP) 		4 VAL A 154
VAL A   8
ILE A 141
ASP A 147
 None
 0.87A 1uwhB-2qesA:
undetectable		 1uwhB-2qesA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 813
ILE A 874
ILE A 730
ASP A 806
 None
 0.78A 1uwhB-2qobA:
28.4		 1uwhB-2qobA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		5 ILE A 165
VAL A 164
VAL A 273
ILE A 240
ASP A 264
 None
 1.42A 1uwhB-2qr6A:
undetectable		 1uwhB-2qr6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxt LIPASE

(Bacillus
subtilis) 		PF01674
(Lipase_2) 		4 ILE A 135
VAL A 136
ILE A  73
ILE A  87
 None
 0.85A 1uwhB-2qxtA:
undetectable		 1uwhB-2qxtA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ILE A 681
VAL A 689
ILE A 736
ASP A 818
 None
 0.71A 1uwhB-2r2pA:
28.4		 1uwhB-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 867
ILE A 928
ILE A 784
ASP A 860
 None
 0.77A 1uwhB-2r2pA:
28.4		 1uwhB-2r2pA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 713
VAL A1013
ILE A1006
ILE A1021
 None
 0.78A 1uwhB-2vdcA:
undetectable		 1uwhB-2vdcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 716
VAL A 715
VAL A 294
ILE A 532
 None
 0.87A 1uwhB-2vdcA:
undetectable		 1uwhB-2vdcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		4 ILE A 270
VAL A 253
VAL A 142
ILE A 173
 None
 0.87A 1uwhB-2w38A:
undetectable		 1uwhB-2w38A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4l DEOXYCYTIDYLATE
DEAMINASE

(Homo sapiens) 		PF00383
(dCMP_cyt_deam_1) 		4 ILE A 162
VAL A 125
ILE A  41
ILE A 117
 ILE  A 162 ( 0.6A)
VAL  A 125 ( 0.6A)
ILE  A  41 ( 0.7A)
ILE  A 117 ( 0.7A)
 0.86A 1uwhB-2w4lA:
undetectable		 1uwhB-2w4lA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE B  75
VAL B  85
VAL B 121
ILE B 130
 ANP  B 432 (-4.4A)
ANP  B 432 (-4.6A)
None
None
 0.79A 1uwhB-2wtkB:
23.4		 1uwhB-2wtkB:
27.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 627
VAL A 635
ILE A 682
ASP A 764
 None
Q9G  A1898 ( 4.7A)
None
None
 0.66A 1uwhB-2xyuA:
29.1		 1uwhB-2xyuA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 813
ILE A 874
ILE A 730
ASP A 806
 None
 0.83A 1uwhB-2xyuA:
29.1		 1uwhB-2xyuA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  30
VAL A  38
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.74A 1uwhB-2y7jA:
15.7		 1uwhB-2y7jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 VAL A  27
ILE A 176
ILE A  23
ASP A 152
 None
 0.75A 1uwhB-2y9xA:
undetectable		 1uwhB-2y9xA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 ILE A 124
VAL A 125
ILE A 298
ASP A 234
 None
 0.85A 1uwhB-2zamA:
undetectable		 1uwhB-2zamA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ILE A 216
VAL A 278
ILE A 194
ILE A 430
 None
 0.86A 1uwhB-2zr2A:
undetectable		 1uwhB-2zr2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9i HOMOCITRATE SYNTHASE

(Thermus
thermophilus) 		PF00682
(HMGL-like) 		4 ILE A  42
VAL A 158
ILE A 123
ASP A  92
 None
None
None
LYS  A 378 (-3.3A)
 0.82A 1uwhB-3a9iA:
undetectable		 1uwhB-3a9iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9i HOMOCITRATE SYNTHASE

(Thermus
thermophilus) 		PF00682
(HMGL-like) 		4 ILE A 231
VAL A 158
ILE A  91
ILE A 120
 None
 0.81A 1uwhB-3a9iA:
undetectable		 1uwhB-3a9iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  18
VAL A  26
ILE A  74
ILE A 137
 3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
None
None
 0.81A 1uwhB-3c0iA:
24.6		 1uwhB-3c0iA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 ILE A 784
VAL A 721
ILE A 728
ILE A 674
 None
 0.82A 1uwhB-3c2gA:
undetectable		 1uwhB-3c2gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A 186
VAL A 183
VAL A  73
ILE A  82
ILE A  10
 None
 1.41A 1uwhB-3db2A:
undetectable		 1uwhB-3db2A:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 825
ILE A 886
ILE A 742
ASP A 818
 None
 0.75A 1uwhB-3dkoA:
28.2		 1uwhB-3dkoA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 150
VAL A 158
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
None
None
VIN  A6331 (-4.0A)
 0.80A 1uwhB-3dtcA:
27.2		 1uwhB-3dtcA:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ILE A  73
VAL A 210
ILE A  91
ILE A 121
 None
 0.81A 1uwhB-3e77A:
undetectable		 1uwhB-3e77A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  32
VAL A  40
ILE A  85
ILE A 147
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
None
None
 0.75A 1uwhB-3e7oA:
20.5		 1uwhB-3e7oA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A  34
VAL A  42
ILE A  85
ASP A 169
 DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
None
None
 0.74A 1uwhB-3f3zA:
8.7		 1uwhB-3f3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ILE A 133
VAL A 150
ILE A  84
ILE A  50
 None
 0.80A 1uwhB-3f9kA:
undetectable		 1uwhB-3f9kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  62
VAL A  70
ILE A 115
ILE A 174
 None
 0.66A 1uwhB-3fe3A:
23.2		 1uwhB-3fe3A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		5 ILE A 239
VAL A 252
VAL A  60
ILE A 162
ASP A  55
 None
 1.35A 1uwhB-3fqdA:
undetectable		 1uwhB-3fqdA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 209
VAL A 217
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
None
None
 0.66A 1uwhB-3g2fA:
24.8		 1uwhB-3g2fA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		4 ILE A 102
VAL A  80
VAL A 240
ILE A 161
 None
None
None
EDO  A 255 (-4.5A)
 0.71A 1uwhB-3ggdA:
undetectable		 1uwhB-3ggdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 VAL A 389
ILE A 403
ILE A 360
ASP A 370
 None
 0.86A 1uwhB-3h09A:
undetectable		 1uwhB-3h09A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		4 ILE A 100
VAL A 130
ILE A  66
ILE A  84
 None
 0.86A 1uwhB-3h5lA:
undetectable		 1uwhB-3h5lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		5 ILE A 125
VAL A 124
ILE A  42
ILE A  85
ASP A  94
 None
 1.45A 1uwhB-3hh8A:
undetectable		 1uwhB-3hh8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn6 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Borreliella
burgdorferi) 		PF01182
(Glucosamine_iso) 		4 ILE A   4
VAL A 238
ILE A  61
ILE A  97
 None
 0.85A 1uwhB-3hn6A:
undetectable		 1uwhB-3hn6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		4 ILE A 964
VAL A 938
VAL A 804
ILE A 820
 None
 0.81A 1uwhB-3hx6A:
undetectable		 1uwhB-3hx6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00579
(tRNA-synt_1b) 		4 ILE A 168
VAL A 165
ILE A 110
ILE A 136
 None
 0.80A 1uwhB-3i05A:
undetectable		 1uwhB-3i05A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4s HISTIDINE TRIAD
PROTEIN

(Bradyrhizobium
japonicum) 		PF01230
(HIT) 		4 VAL A 144
VAL A 101
ILE A 108
ILE A 169
 None
 0.70A 1uwhB-3i4sA:
3.0		 1uwhB-3i4sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 209
VAL A 217
ILE A 244
ILE A 123
 None
 0.69A 1uwhB-3icsA:
undetectable		 1uwhB-3icsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A  59
VAL A  67
ILE A 112
ILE A 171
ASP A 193
 None
 0.90A 1uwhB-3iecA:
23.5		 1uwhB-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jte RESPONSE REGULATOR
RECEIVER PROTEIN

(Ruminiclostridium
thermocellum) 		PF00072
(Response_reg) 		4 ILE A  25
VAL A  80
ILE A  50
ILE A  71
 None
 0.87A 1uwhB-3jteA:
undetectable		 1uwhB-3jteA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		4 VAL A 130
ILE A 221
ILE A 214
ASP A 194
 None
 0.72A 1uwhB-3k6rA:
undetectable		 1uwhB-3k6rA:
20.92