SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWH_A_BAXA1723_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f3g | GLUCOSE-SPECIFICPHOSPHOCARRIERPROTEIN IIAGLC (Escherichiacoli) |
PF00358(PTS_EIIA_1) | 4 | VAL A 113VAL A 163ILE A 140ILE A 50 | None | 0.82A | 1uwhA-1f3gA:undetectable | 1uwhA-1f3gA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0u | PROTEASOME COMPONENTPUP2 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | ILE D 196VAL D 68ILE D 138ILE D 89 | None | 0.77A | 1uwhA-1g0uD:undetectable | 1uwhA-1g0uD:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gng | GLYCOGEN SYNTHASEKINASE-3 BETA (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 62VAL A 70ILE A 109ILE A 177 | None | 0.57A | 1uwhA-1gngA:21.8 | 1uwhA-1gngA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hf2 | SEPTUMSITE-DETERMININGPROTEIN MINC (Thermotogamaritima) |
PF03775(MinC_C) | 4 | ILE A 62VAL A 63VAL A 122ILE A 148 | None | 0.79A | 1uwhA-1hf2A:undetectable | 1uwhA-1hf2A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyg | L-LACTATE/MALATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ILE A 236VAL A 284ILE A 175ILE A 286 | None | 0.70A | 1uwhA-1hygA:undetectable | 1uwhA-1hygA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyh | L-2-HYDROXYISOCAPROATE DEHYDROGENASE (Weissellaconfusa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ILE A 290VAL A 263VAL A 50ILE A 27 | None | 0.76A | 1uwhA-1hyhA:undetectable | 1uwhA-1hyhA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k4q | GLUTATHIONEREDUCTASE (Homo sapiens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ILE A 205VAL A 251ILE A 289ILE A 168 | None | 0.71A | 1uwhA-1k4qA:undetectable | 1uwhA-1k4qA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lth | L-LACTATEDEHYDROGENASE (T-AND R- STATETETRAMER COMPLEX) (Bifidobacteriumlongum) |
no annotation | 4 | VAL T 251VAL T 36ILE T 13ILE T 72 | None | 0.64A | 1uwhA-1lthT:undetectable | 1uwhA-1lthT:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1py5 | TGF-BETA RECEPTORTYPE I (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 4 | ILE A 211VAL A 219ILE A 259ILE A 329 | PY1 A 700 (-3.6A)PY1 A 700 ( 4.7A)NoneNone | 0.64A | 1uwhA-1py5A:25.6 | 1uwhA-1py5A:29.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | VAL A 603VAL A 643ILE A 653ASP A 810 | STI A 3 ( 4.6A)NoneNoneSTI A 3 (-3.9A) | 0.69A | 1uwhA-1t46A:19.3 | 1uwhA-1t46A:30.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7n | FATTYACID/PHOSPHOLIPIDSYNTHESIS PROTEINPLSX (Enterococcusfaecalis) |
PF02504(FA_synthesis) | 4 | ILE A 110VAL A 111ILE A 309ASP A 92 | None | 0.77A | 1uwhA-1u7nA:undetectable | 1uwhA-1u7nA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5c | CHITOSANASE (Bacillus sp.(in: Bacteria)) |
PF01270(Glyco_hydro_8) | 4 | ILE A 215ILE A 327ILE A 290ASP A 247 | None | 0.76A | 1uwhA-1v5cA:undetectable | 1uwhA-1v5cA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vi1 | FATTYACID/PHOSPHOLIPIDSYNTHESIS PROTEINPLSX (Bacillussubtilis) |
PF02504(FA_synthesis) | 4 | ILE A 111VAL A 112ILE A 307ASP A 93 | None | 0.73A | 1uwhA-1vi1A:undetectable | 1uwhA-1vi1A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wn1 | DIPEPTIDASE (Pyrococcushorikoshii) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | ILE A 285ILE A 212ILE A 154ASP A 215 | NoneNoneNone CO A1003 (-2.8A) | 0.78A | 1uwhA-1wn1A:undetectable | 1uwhA-1wn1A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1n | 4-ALPHA-GLUCANOTRANSFERASE (Solanumtuberosum) |
PF02446(Glyco_hydro_77) | 4 | ILE A 356VAL A 360ILE A 238ASP A 313 | None | 0.76A | 1uwhA-1x1nA:undetectable | 1uwhA-1x1nA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7e | PROTEIN ARNA (Escherichiacoli) |
PF00551(Formyl_trans_N)PF01370(Epimerase)PF02911(Formyl_trans_C) | 5 | ILE A 144VAL A 145VAL A 4ILE A 88ILE A 71 | None | 1.18A | 1uwhA-1z7eA:undetectable | 1uwhA-1z7eA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 5 | ILE A 137VAL A 138ILE A 95ILE A 86ASP A 110 | None | 0.95A | 1uwhA-1zdrA:undetectable | 1uwhA-1zdrA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj0 | PUTATIVE CITRATELYASE, ALFA SUBUNIT (Streptococcusmutans) |
PF04223(CitF) | 4 | ILE A 134VAL A 130ILE A 87ILE A 52 | None | 0.75A | 1uwhA-2hj0A:undetectable | 1uwhA-2hj0A:20.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2jkm | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF07714(Pkinase_Tyr) | 4 | ILE A 428VAL A 436ILE A 483ASP A 564 | BII A1687 (-3.8A)BII A1687 ( 4.7A)NoneNone | 0.67A | 1uwhA-2jkmA:29.0 | 1uwhA-2jkmA:30.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og2 | PUTATIVE SIGNALRECOGNITION PARTICLERECEPTOR (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | ILE A 278VAL A 197ILE A 184ASP A 163 | None | 0.78A | 1uwhA-2og2A:undetectable | 1uwhA-2og2A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qob | EPHRIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | VAL A 813ILE A 874ILE A 730ASP A 806 | None | 0.77A | 1uwhA-2qobA:28.7 | 1uwhA-2qobA:28.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 4 | ILE A 681VAL A 689ILE A 736ASP A 818 | None | 0.70A | 1uwhA-2r2pA:28.7 | 1uwhA-2r2pA:32.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 4 | VAL A 867ILE A 928ILE A 784ASP A 860 | None | 0.77A | 1uwhA-2r2pA:28.7 | 1uwhA-2r2pA:32.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 4 | ILE A 713VAL A1013ILE A1006ILE A1021 | None | 0.78A | 1uwhA-2vdcA:undetectable | 1uwhA-2vdcA:11.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 4 | ILE A 627VAL A 635ILE A 682ASP A 764 | NoneQ9G A1898 ( 4.7A)NoneNone | 0.66A | 1uwhA-2xyuA:29.4 | 1uwhA-2xyuA:32.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7j | PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 30VAL A 38ILE A 90ILE A 149 | B49 A1294 (-3.9A)NoneNoneNone | 0.73A | 1uwhA-2y7jA:15.7 | 1uwhA-2y7jA:23.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dko | EPHRIN TYPE-ARECEPTOR 7 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 4 | VAL A 825ILE A 886ILE A 742ASP A 818 | None | 0.75A | 1uwhA-3dkoA:28.5 | 1uwhA-3dkoA:30.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dtc | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 9 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | ILE A 150ILE A 203ILE A 264ASP A 294 | VIN A6331 (-4.0A)NoneNoneVIN A6331 (-4.0A) | 0.70A | 1uwhA-3dtcA:27.5 | 1uwhA-3dtcA:34.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dtc | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 9 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | ILE A 150VAL A 158ILE A 203ILE A 264 | VIN A6331 (-4.0A)VIN A6331 (-4.7A)NoneNone | 0.66A | 1uwhA-3dtcA:27.5 | 1uwhA-3dtcA:34.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7o | MITOGEN-ACTIVATEDPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 32VAL A 40ILE A 85ILE A 147 | 35F A 1 ( 4.4A)35F A 1 ( 4.8A)NoneNone | 0.75A | 1uwhA-3e7oA:20.6 | 1uwhA-3e7oA:27.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase) | 4 | ILE A 34VAL A 42ILE A 85ASP A 169 | DRK A 1 (-4.2A)DRK A 1 ( 4.9A)NoneNone | 0.74A | 1uwhA-3f3zA:14.7 | 1uwhA-3f3zA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9k | INTEGRASE (Humanimmunodeficiencyvirus 2) |
PF00665(rve)PF02022(Integrase_Zn) | 4 | ILE A 133VAL A 150ILE A 84ILE A 50 | None | 0.79A | 1uwhA-3f9kA:undetectable | 1uwhA-3f9kA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fe3 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 3 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 4 | ILE A 62VAL A 70ILE A 115ILE A 174 | None | 0.66A | 1uwhA-3fe3A:23.2 | 1uwhA-3fe3A:27.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g2f | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-2 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 209VAL A 217ILE A 257ILE A 329 | ADP A 900 (-4.6A)ADP A 900 (-4.3A)NoneNone | 0.66A | 1uwhA-3g2fA:24.8 | 1uwhA-3g2fA:28.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggd | SAM-DEPENDENTMETHYLTRANSFERASE (Trichormusvariabilis) |
PF13649(Methyltransf_25) | 4 | ILE A 102VAL A 80VAL A 240ILE A 161 | NoneNoneNoneEDO A 255 (-4.5A) | 0.71A | 1uwhA-3ggdA:undetectable | 1uwhA-3ggdA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hx6 | TYPE 4 FIMBRIALBIOGENESIS PROTEINPILY1 (Pseudomonasaeruginosa) |
PF05567(Neisseria_PilC) | 4 | ILE A 964VAL A 938VAL A 804ILE A 820 | None | 0.81A | 1uwhA-3hx6A:undetectable | 1uwhA-3hx6A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i05 | TRYPTOPHANYL-TRNASYNTHETASE (Trypanosomabrucei) |
PF00579(tRNA-synt_1b) | 4 | ILE A 168VAL A 165ILE A 110ILE A 136 | None | 0.79A | 1uwhA-3i05A:undetectable | 1uwhA-3i05A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4s | HISTIDINE TRIADPROTEIN (Bradyrhizobiumjaponicum) |
PF01230(HIT) | 4 | VAL A 144VAL A 101ILE A 108ILE A 169 | None | 0.69A | 1uwhA-3i4sA:3.0 | 1uwhA-3i4sA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ics | COENZYME A-DISULFIDEREDUCTASE (Bacillusanthracis) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | VAL A 209VAL A 217ILE A 244ILE A 123 | None | 0.69A | 1uwhA-3icsA:undetectable | 1uwhA-3icsA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 4 | ILE A 59VAL A 67ILE A 112ASP A 193 | None | 0.68A | 1uwhA-3iecA:23.6 | 1uwhA-3iecA:28.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 4 | ILE A 59VAL A 67ILE A 112ILE A 171 | None | 0.79A | 1uwhA-3iecA:23.6 | 1uwhA-3iecA:28.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6r | PUTATIVE TRANSFERASEPH0793 (Pyrococcushorikoshii) |
PF02475(Met_10) | 4 | VAL A 130ILE A 221ILE A 214ASP A 194 | None | 0.71A | 1uwhA-3k6rA:undetectable | 1uwhA-3k6rA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7g | XAA-PRO DIPEPTIDASE (Alteromonas sp.) |
PF00557(Peptidase_M24) | 4 | ILE A 63VAL A 52VAL A 149ILE A 22 | None | 0.70A | 1uwhA-3l7gA:undetectable | 1uwhA-3l7gA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lij | CALCIUM/CALMODULINDEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 4 | VAL A 76VAL A 112ILE A 121ILE A 180 | ANP A 522 (-4.1A)NoneNoneNone | 0.44A | 1uwhA-3lijA:24.8 | 1uwhA-3lijA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljp | CHOLINE OXIDASE (Arthrobacterglobiformis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | ILE A 75VAL A 401VAL A 502ILE A 518 | None | 0.74A | 1uwhA-3ljpA:undetectable | 1uwhA-3ljpA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m99 | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Saccharomycescerevisiae) |
PF00443(UCH)PF02148(zf-UBP) | 4 | VAL A 359VAL A 455ILE A 429ILE A 450 | None | 0.72A | 1uwhA-3m99A:undetectable | 1uwhA-3m99A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2c | PROLIDASE (unidentified) |
PF01979(Amidohydro_1) | 5 | ILE A 357VAL A 358ILE A 367ILE A 27ASP A 374 | None | 0.97A | 1uwhA-3n2cA:undetectable | 1uwhA-3n2cA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00365(PFK) | 4 | VAL A 548VAL A 397ILE A 355ILE A 375 | NoneNoneF6P A 988 (-4.9A)None | 0.80A | 1uwhA-3o8oA:undetectable | 1uwhA-3o8oA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT BETA (Saccharomycescerevisiae) |
PF00365(PFK) | 4 | VAL B 541VAL B 389ILE B 347ILE B 367 | None | 0.83A | 1uwhA-3o8oB:undetectable | 1uwhA-3o8oB:17.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A 355VAL A 363VAL A 396ILE A 405ILE A 464 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)NoneNoneNone | 0.53A | 1uwhA-3omvA:36.4 | 1uwhA-3omvA:72.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psi | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 4 | VAL A 574VAL A 538ILE A 682ASP A 516 | None | 0.75A | 1uwhA-3psiA:undetectable | 1uwhA-3psiA:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 206VAL A 235ILE A 246ILE A 318 | TAK A 2 ( 4.9A)EDO A 489 ( 4.8A)NoneNone | 0.55A | 1uwhA-3q4tA:25.3 | 1uwhA-3q4tA:28.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sto | SERINE PROTEASEINHIBITOR (Schistosomahaematobium) |
PF00079(Serpin) | 4 | ILE A 46VAL A 256ILE A 382ILE A 243 | None | 0.82A | 1uwhA-3stoA:undetectable | 1uwhA-3stoA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzw | TYROSINE-PROTEINKINASE TRANSMEMBRANERECEPTOR ROR2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | VAL A 681ILE A 742ILE A 599ASP A 674 | None | 0.73A | 1uwhA-3zzwA:27.6 | 1uwhA-3zzwA:29.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4apw | ALP12 (Clostridiumtetani) |
no annotation | 4 | ILE A 283VAL A 176VAL A 116ILE A 154 | None | 0.75A | 1uwhA-4apwA:undetectable | 1uwhA-4apwA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0j | MITOCHONDRIAL RHOGTPASE (Drosophilamelanogaster) |
PF00071(Ras)PF08355(EF_assoc_1)PF08356(EF_assoc_2) | 4 | ILE A 373ILE A 427ILE A 319ASP A 402 | None | 0.80A | 1uwhA-4c0jA:undetectable | 1uwhA-4c0jA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czx | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2 (Neurosporacrassa) |
no annotation | 4 | ILE A 181VAL A 143ILE A 124ILE A 103 | None | 0.79A | 1uwhA-4czxA:undetectable | 1uwhA-4czxA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d2i | HERA (Sulfolobussolfataricus) |
PF01935(DUF87)PF05872(DUF853)PF09378(HAS-barrel) | 4 | ILE A 291VAL A 290ILE A 299ILE A 350 | None | 0.81A | 1uwhA-4d2iA:undetectable | 1uwhA-4d2iA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4drs | PYRUVATE KINASE (Cryptosporidiumparvum) |
PF00224(PK)PF02887(PK_C) | 4 | ILE A 271VAL A 292ILE A 389ASP A 354 | None | 0.65A | 1uwhA-4drsA:undetectable | 1uwhA-4drsA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igg | CATENIN ALPHA-1 (Homo sapiens) |
PF01044(Vinculin) | 5 | ILE A 632VAL A 629VAL A 390ILE A 505ASP A 510 | None | 1.32A | 1uwhA-4iggA:undetectable | 1uwhA-4iggA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lct | COP9 SIGNALOSOMECOMPLEX SUBUNIT 1 (Arabidopsisthaliana) |
PF01399(PCI)PF10602(RPN7) | 4 | VAL A 292VAL A 252ILE A 325ILE A 187 | None | 0.77A | 1uwhA-4lctA:2.1 | 1uwhA-4lctA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lix | ENT-COPALYLDIPHOSPHATESYNTHASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 4 | ILE A 208VAL A 171ILE A 220ILE A 226 | AG8 A 901 (-4.3A)NoneNoneNone | 0.82A | 1uwhA-4lixA:undetectable | 1uwhA-4lixA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pf8 | TRAP-T FAMILYTRANSPORTER, DCTP(PERIPLASMICBINDING) SUBUNIT (Sulfitobactersp. NAS-14.1) |
PF03480(DctP) | 4 | ILE A 254VAL A 50ILE A 136ASP A 84 | None | 0.83A | 1uwhA-4pf8A:undetectable | 1uwhA-4pf8A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9t | NUCLEOPORIN NUP133 (Vanderwaltozymapolyspora) |
PF08801(Nucleoporin_N) | 4 | ILE A 285VAL A 433ILE A 356ILE A 446 | None | 0.81A | 1uwhA-4q9tA:undetectable | 1uwhA-4q9tA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0i | SUPPRESSOR OFTUMORIGENICITY 14PROTEIN (Homo sapiens) |
PF00089(Trypsin) | 4 | ILE A 163VAL A 162ILE A 103ILE A 238 | None | 0.82A | 1uwhA-4r0iA:undetectable | 1uwhA-4r0iA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u1r | ATP-DEPENDENT6-PHOSPHOFRUCTOKINASE, PLATELET TYPE (Homo sapiens) |
PF00365(PFK) | 4 | VAL A 367VAL A 216ILE A 174ILE A 194 | None | 0.81A | 1uwhA-4u1rA:undetectable | 1uwhA-4u1rA:16.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uy9 | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 150VAL A 158ILE A 203ILE A 264 | None | 0.64A | 1uwhA-4uy9A:27.2 | 1uwhA-4uy9A:31.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xrl | MITOGEN-ACTIVATEDPROTEIN KINASE 1 (Rattusnorvegicus) |
PF00069(Pkinase) | 4 | ILE A 29VAL A 37ILE A 81ASP A 165 | 42A A 402 ( 4.7A)NoneNoneNone | 0.62A | 1uwhA-4xrlA:22.3 | 1uwhA-4xrlA:27.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylj | DUAL SPECIFICITYTYROSINE-PHOSPHORYLATION-REGULATEDKINASE 1A (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 165VAL A 173ILE A 221ILE A 283 | 4E1 A 505 ( 4.6A)4E1 A 505 (-4.5A)NoneNone | 0.62A | 1uwhA-4yljA:20.9 | 1uwhA-4yljA:27.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypw | TRNA(GUANINE-N(1)-)-METHYLTRANSFERASE (Haemophilusinfluenzae) |
PF01746(tRNA_m1G_MT) | 4 | VAL A 33VAL A 99ILE A 133ASP A 150 | NoneNone4FD A 301 (-4.1A)None | 0.82A | 1uwhA-4ypwA:undetectable | 1uwhA-4ypwA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEMOLYBDOPTERIN-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ILE A 541VAL A 542VAL A 436ILE A 475ASP A 553 | None | 1.42A | 1uwhA-4zohA:undetectable | 1uwhA-4zohA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zsl | MITOGEN-ACTIVATEDPROTEIN KINASE 7 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 61VAL A 69ILE A 114ASP A 200 | None | 0.73A | 1uwhA-4zslA:21.2 | 1uwhA-4zslA:26.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zwo | ORGANOPHOSPHATEANHYDROLASE/PROLIDASE (Alteromonas sp.) |
PF00557(Peptidase_M24) | 4 | ILE A 63VAL A 52VAL A 149ILE A 22 | None | 0.75A | 1uwhA-4zwoA:undetectable | 1uwhA-4zwoA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4j | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 4 | ILE A 93VAL A 298VAL A 366ILE A 64 | None | 0.80A | 1uwhA-5a4jA:undetectable | 1uwhA-5a4jA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahv | ANTH DOMAIN OFENDOCYTIC ADAPTORSLA2ENTH DOMAIN OF EPSINENT1 (Saccharomycescerevisiae) |
PF01417(ENTH)PF07651(ANTH) | 4 | ILE F 188VAL F 252ILE E 102ILE E 84 | None | 0.77A | 1uwhA-5ahvF:undetectable | 1uwhA-5ahvF:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awm | STRESS-ACTIVATEDPROTEIN KINASE JNK (Drosophilamelanogaster) |
PF00069(Pkinase) | 4 | ILE A 30VAL A 38ILE A 83ILE A 145 | ANP A 401 (-4.9A)ANP A 401 (-4.5A)NoneNone | 0.79A | 1uwhA-5awmA:7.0 | 1uwhA-5awmA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci6 | MITOGEN-ACTIVATEDPROTEIN KINASE 6 (Arabidopsisthaliana) |
PF00069(Pkinase) | 4 | ILE A 69VAL A 77ILE A 122ASP A 207 | None | 0.70A | 1uwhA-5ci6A:21.3 | 1uwhA-5ci6A:25.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ci7 | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 22VAL A 30ILE A 75ILE A 134 | 51W A 401 (-3.9A)51W A 401 ( 4.3A)NoneNone | 0.71A | 1uwhA-5ci7A:23.8 | 1uwhA-5ci7A:31.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dll | AMINOPEPTIDASE N (Francisellatularensis) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 4 | ILE A 555VAL A 556VAL A 637ILE A 577 | None | 0.76A | 1uwhA-5dllA:undetectable | 1uwhA-5dllA:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmy | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | ILE A 848VAL A 820ILE A 172ASP A 63 | None | 0.71A | 1uwhA-5dmyA:undetectable | 1uwhA-5dmyA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ezr | CGMP-DEPENDENTPROTEIN KINASE,PUTATIVE (Plasmodiumvivax) |
PF00027(cNMP_binding)PF00069(Pkinase) | 4 | ILE A 540VAL A 548ILE A 594ILE A 653 | 4ZS A 901 (-4.2A)4ZS A 901 (-4.8A)NoneNone | 0.77A | 1uwhA-5ezrA:20.0 | 1uwhA-5ezrA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT RRP42 (Saccharomycescerevisiae) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 4 | VAL E 92ILE E 141ILE E 82ASP E 79 | None | 0.82A | 1uwhA-5g06E:undetectable | 1uwhA-5g06E:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h4r | BETA-1,3-1,4-GLUCANASE (Caldicellulosiruptorsp. F32) |
PF00150(Cellulase) | 4 | ILE A 387VAL A 44ILE A 137ILE A 268 | None | 0.81A | 1uwhA-5h4rA:undetectable | 1uwhA-5h4rA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3s | INOSITOLMONOPHOSPHATASEFAMILY PROTEIN (Staphylococcusaureus) |
PF00459(Inositol_P) | 4 | ILE A 239VAL A 62ILE A 104ILE A 53 | None | 0.74A | 1uwhA-5i3sA:undetectable | 1uwhA-5i3sA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jt8 | BLO T 1 ALLERGEN (Blomiatropicalis) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 4 | ILE A 177VAL A 207VAL A 268ILE A 234 | CL A 402 ( 4.4A)NoneNoneNone | 0.71A | 1uwhA-5jt8A:undetectable | 1uwhA-5jt8A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 276VAL A 284ILE A 327ASP A 407 | IPW A 601 (-4.0A)IPW A 601 (-4.2A)NoneNone | 0.74A | 1uwhA-5kbrA:23.7 | 1uwhA-5kbrA:29.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l6o | EPHRIN TYPE-BRECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | VAL A 827ILE A 888ILE A 742ASP A 820 | None | 0.76A | 1uwhA-5l6oA:28.6 | 1uwhA-5l6oA:32.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oat | SERINE/THREONINE-PROTEIN KINASE PINK1,MITOCHONDRIAL-LIKEPROTEIN (Triboliumcastaneum) |
no annotation | 4 | ILE A 168VAL A 176VAL A 219ILE A 250 | None | 0.72A | 1uwhA-5oatA:20.8 | 1uwhA-5oatA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oat | SERINE/THREONINE-PROTEIN KINASE PINK1,MITOCHONDRIAL-LIKEPROTEIN (Triboliumcastaneum) |
no annotation | 4 | ILE A 168VAL A 219ILE A 250ILE A 333 | None | 0.78A | 1uwhA-5oatA:20.8 | 1uwhA-5oatA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj1 | MDCA (Pseudomonasaeruginosa) |
PF16957(Mal_decarbox_Al) | 4 | ILE A 222VAL A 53ILE A 187ILE A 47 | None | 0.64A | 1uwhA-5vj1A:undetectable | 1uwhA-5vj1A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6o | DNA DAMAGECHECKPOINT PROTEINLCD1 (Saccharomycescerevisiae) |
no annotation | 4 | ILE G 428VAL G 424VAL G 300ILE G 282 | None | 0.78A | 1uwhA-5x6oG:2.3 | 1uwhA-5x6oG:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xap | PROTEIN TRANSLOCASESUBUNIT SECD (Deinococcusradiodurans) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 4 | ILE A 628VAL A 402ILE A 369ASP A 666 | None | 0.82A | 1uwhA-5xapA:undetectable | 1uwhA-5xapA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvu | CASEIN KINASE 2,ALPHA SUBUNIT (Plasmodiumfalciparum) |
PF00069(Pkinase) | 4 | ILE A 49VAL A 57ILE A 98ILE A 156 | ATP A 403 (-4.9A)ATP A 403 (-3.9A)NoneNone | 0.58A | 1uwhA-5xvuA:21.9 | 1uwhA-5xvuA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xzw | SERINE/THREONINE-PROTEIN KINASE RAD53 (Saccharomycescerevisiae) |
no annotation | 4 | VAL A 212VAL A 247ILE A 256ILE A 315 | None | 0.78A | 1uwhA-5xzwA:20.5 | 1uwhA-5xzwA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | X-RAY REPAIRCROSS-COMPLEMENTINGPROTEIN 5 (Homo sapiens) |
PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N) | 4 | ILE B 267VAL B 342ILE B 261ILE B 253 | None | 0.78A | 1uwhA-5y3rB:undetectable | 1uwhA-5y3rB:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9a | CHORISMATE SYNTHASE (Pseudomonasaeruginosa) |
no annotation | 4 | ILE A 81VAL A 27ILE A 150ILE A 285 | None | 0.81A | 1uwhA-5z9aA:undetectable | 1uwhA-5z9aA:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4w | DUAL SPECIFICITYPROTEIN KINASE TTK (Homo sapiens) |
no annotation | 5 | ILE A 531VAL A 539ILE A 585ILE A 643ASP A 664 | CQ7 A 801 (-3.6A)CQ7 A 801 ( 4.8A)NoneNoneNone | 0.84A | 1uwhA-6b4wA:24.7 | 1uwhA-6b4wA:26.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7v | - (-) |
no annotation | 4 | ILE A 173VAL A 125ILE A 83ILE A 116 | None | 0.82A | 1uwhA-6c7vA:undetectable | 1uwhA-6c7vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqi | SERINE/THREONINE-PROTEIN KINASE PINK1,PUTATIVE (Pediculushumanus) |
no annotation | 4 | ILE C 165VAL C 173ILE C 246ILE C 330 | None | 0.60A | 1uwhA-6eqiC:20.8 | 1uwhA-6eqiC:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqi | SERINE/THREONINE-PROTEIN KINASE PINK1,PUTATIVE (Pediculushumanus) |
no annotation | 4 | ILE C 165VAL C 173VAL C 216ILE C 246 | None | 0.71A | 1uwhA-6eqiC:20.8 | 1uwhA-6eqiC:23.94 |