SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWH_A_BAXA1723_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC


(Escherichia
coli)
PF00358
(PTS_EIIA_1)
4 VAL A 113
VAL A 163
ILE A 140
ILE A  50
None
0.82A 1uwhA-1f3gA:
undetectable
1uwhA-1f3gA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
4 ILE D 196
VAL D  68
ILE D 138
ILE D  89
None
0.77A 1uwhA-1g0uD:
undetectable
1uwhA-1g0uD:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  62
VAL A  70
ILE A 109
ILE A 177
None
0.57A 1uwhA-1gngA:
21.8
1uwhA-1gngA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC


(Thermotoga
maritima)
PF03775
(MinC_C)
4 ILE A  62
VAL A  63
VAL A 122
ILE A 148
None
0.79A 1uwhA-1hf2A:
undetectable
1uwhA-1hf2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A 236
VAL A 284
ILE A 175
ILE A 286
None
0.70A 1uwhA-1hygA:
undetectable
1uwhA-1hygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE


(Weissella
confusa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A 290
VAL A 263
VAL A  50
ILE A  27
None
0.76A 1uwhA-1hyhA:
undetectable
1uwhA-1hyhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE


(Homo sapiens)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ILE A 205
VAL A 251
ILE A 289
ILE A 168
None
0.71A 1uwhA-1k4qA:
undetectable
1uwhA-1k4qA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)


(Bifidobacterium
longum)
no annotation 4 VAL T 251
VAL T  36
ILE T  13
ILE T  72
None
0.64A 1uwhA-1lthT:
undetectable
1uwhA-1lthT:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
4 ILE A 211
VAL A 219
ILE A 259
ILE A 329
PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
None
None
0.64A 1uwhA-1py5A:
25.6
1uwhA-1py5A:
29.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 VAL A 603
VAL A 643
ILE A 653
ASP A 810
STI  A   3 ( 4.6A)
None
None
STI  A   3 (-3.9A)
0.69A 1uwhA-1t46A:
19.3
1uwhA-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX


(Enterococcus
faecalis)
PF02504
(FA_synthesis)
4 ILE A 110
VAL A 111
ILE A 309
ASP A  92
None
0.77A 1uwhA-1u7nA:
undetectable
1uwhA-1u7nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria))
PF01270
(Glyco_hydro_8)
4 ILE A 215
ILE A 327
ILE A 290
ASP A 247
None
0.76A 1uwhA-1v5cA:
undetectable
1uwhA-1v5cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX


(Bacillus
subtilis)
PF02504
(FA_synthesis)
4 ILE A 111
VAL A 112
ILE A 307
ASP A  93
None
0.73A 1uwhA-1vi1A:
undetectable
1uwhA-1vi1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 ILE A 285
ILE A 212
ILE A 154
ASP A 215
None
None
None
CO  A1003 (-2.8A)
0.78A 1uwhA-1wn1A:
undetectable
1uwhA-1wn1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE


(Solanum
tuberosum)
PF02446
(Glyco_hydro_77)
4 ILE A 356
VAL A 360
ILE A 238
ASP A 313
None
0.76A 1uwhA-1x1nA:
undetectable
1uwhA-1x1nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli)
PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C)
5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
None
1.18A 1uwhA-1z7eA:
undetectable
1uwhA-1z7eA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdr DIHYDROFOLATE
REDUCTASE


(Geobacillus
stearothermophilus)
PF00186
(DHFR_1)
5 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
None
0.95A 1uwhA-1zdrA:
undetectable
1uwhA-1zdrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT


(Streptococcus
mutans)
PF04223
(CitF)
4 ILE A 134
VAL A 130
ILE A  87
ILE A  52
None
0.75A 1uwhA-2hj0A:
undetectable
1uwhA-2hj0A:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF07714
(Pkinase_Tyr)
4 ILE A 428
VAL A 436
ILE A 483
ASP A 564
BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
None
None
0.67A 1uwhA-2jkmA:
29.0
1uwhA-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 ILE A 278
VAL A 197
ILE A 184
ASP A 163
None
0.78A 1uwhA-2og2A:
undetectable
1uwhA-2og2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 VAL A 813
ILE A 874
ILE A 730
ASP A 806
None
0.77A 1uwhA-2qobA:
28.7
1uwhA-2qobA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
4 ILE A 681
VAL A 689
ILE A 736
ASP A 818
None
0.70A 1uwhA-2r2pA:
28.7
1uwhA-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
4 VAL A 867
ILE A 928
ILE A 784
ASP A 860
None
0.77A 1uwhA-2r2pA:
28.7
1uwhA-2r2pA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
4 ILE A 713
VAL A1013
ILE A1006
ILE A1021
None
0.78A 1uwhA-2vdcA:
undetectable
1uwhA-2vdcA:
11.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
4 ILE A 627
VAL A 635
ILE A 682
ASP A 764
None
Q9G  A1898 ( 4.7A)
None
None
0.66A 1uwhA-2xyuA:
29.4
1uwhA-2xyuA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  30
VAL A  38
ILE A  90
ILE A 149
B49  A1294 (-3.9A)
None
None
None
0.73A 1uwhA-2y7jA:
15.7
1uwhA-2y7jA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
4 VAL A 825
ILE A 886
ILE A 742
ASP A 818
None
0.75A 1uwhA-3dkoA:
28.5
1uwhA-3dkoA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 ILE A 150
ILE A 203
ILE A 264
ASP A 294
VIN  A6331 (-4.0A)
None
None
VIN  A6331 (-4.0A)
0.70A 1uwhA-3dtcA:
27.5
1uwhA-3dtcA:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 ILE A 150
VAL A 158
ILE A 203
ILE A 264
VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
None
None
0.66A 1uwhA-3dtcA:
27.5
1uwhA-3dtcA:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  32
VAL A  40
ILE A  85
ILE A 147
35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
None
None
0.75A 1uwhA-3e7oA:
20.6
1uwhA-3e7oA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
4 ILE A  34
VAL A  42
ILE A  85
ASP A 169
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
None
None
0.74A 1uwhA-3f3zA:
14.7
1uwhA-3f3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2)
PF00665
(rve)
PF02022
(Integrase_Zn)
4 ILE A 133
VAL A 150
ILE A  84
ILE A  50
None
0.79A 1uwhA-3f9kA:
undetectable
1uwhA-3f9kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
4 ILE A  62
VAL A  70
ILE A 115
ILE A 174
None
0.66A 1uwhA-3fe3A:
23.2
1uwhA-3fe3A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A 209
VAL A 217
ILE A 257
ILE A 329
ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
None
None
0.66A 1uwhA-3g2fA:
24.8
1uwhA-3g2fA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE


(Trichormus
variabilis)
PF13649
(Methyltransf_25)
4 ILE A 102
VAL A  80
VAL A 240
ILE A 161
None
None
None
EDO  A 255 (-4.5A)
0.71A 1uwhA-3ggdA:
undetectable
1uwhA-3ggdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1


(Pseudomonas
aeruginosa)
PF05567
(Neisseria_PilC)
4 ILE A 964
VAL A 938
VAL A 804
ILE A 820
None
0.81A 1uwhA-3hx6A:
undetectable
1uwhA-3hx6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE


(Trypanosoma
brucei)
PF00579
(tRNA-synt_1b)
4 ILE A 168
VAL A 165
ILE A 110
ILE A 136
None
0.79A 1uwhA-3i05A:
undetectable
1uwhA-3i05A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4s HISTIDINE TRIAD
PROTEIN


(Bradyrhizobium
japonicum)
PF01230
(HIT)
4 VAL A 144
VAL A 101
ILE A 108
ILE A 169
None
0.69A 1uwhA-3i4sA:
3.0
1uwhA-3i4sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE


(Bacillus
anthracis)
PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 VAL A 209
VAL A 217
ILE A 244
ILE A 123
None
0.69A 1uwhA-3icsA:
undetectable
1uwhA-3icsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
4 ILE A  59
VAL A  67
ILE A 112
ASP A 193
None
0.68A 1uwhA-3iecA:
23.6
1uwhA-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
4 ILE A  59
VAL A  67
ILE A 112
ILE A 171
None
0.79A 1uwhA-3iecA:
23.6
1uwhA-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793


(Pyrococcus
horikoshii)
PF02475
(Met_10)
4 VAL A 130
ILE A 221
ILE A 214
ASP A 194
None
0.71A 1uwhA-3k6rA:
undetectable
1uwhA-3k6rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.)
PF00557
(Peptidase_M24)
4 ILE A  63
VAL A  52
VAL A 149
ILE A  22
None
0.70A 1uwhA-3l7gA:
undetectable
1uwhA-3l7gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 VAL A  76
VAL A 112
ILE A 121
ILE A 180
ANP  A 522 (-4.1A)
None
None
None
0.44A 1uwhA-3lijA:
24.8
1uwhA-3lijA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ILE A  75
VAL A 401
VAL A 502
ILE A 518
None
0.74A 1uwhA-3ljpA:
undetectable
1uwhA-3ljpA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Saccharomyces
cerevisiae)
PF00443
(UCH)
PF02148
(zf-UBP)
4 VAL A 359
VAL A 455
ILE A 429
ILE A 450
None
0.72A 1uwhA-3m99A:
undetectable
1uwhA-3m99A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified)
PF01979
(Amidohydro_1)
5 ILE A 357
VAL A 358
ILE A 367
ILE A  27
ASP A 374
None
0.97A 1uwhA-3n2cA:
undetectable
1uwhA-3n2cA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
4 VAL A 548
VAL A 397
ILE A 355
ILE A 375
None
None
F6P  A 988 (-4.9A)
None
0.80A 1uwhA-3o8oA:
undetectable
1uwhA-3o8oA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
4 VAL B 541
VAL B 389
ILE B 347
ILE B 367
None
0.83A 1uwhA-3o8oB:
undetectable
1uwhA-3o8oB:
17.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 355
VAL A 363
VAL A 396
ILE A 405
ILE A 464
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
None
None
None
0.53A 1uwhA-3omvA:
36.4
1uwhA-3omvA:
72.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
4 VAL A 574
VAL A 538
ILE A 682
ASP A 516
None
0.75A 1uwhA-3psiA:
undetectable
1uwhA-3psiA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 206
VAL A 235
ILE A 246
ILE A 318
TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
None
None
0.55A 1uwhA-3q4tA:
25.3
1uwhA-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR


(Schistosoma
haematobium)
PF00079
(Serpin)
4 ILE A  46
VAL A 256
ILE A 382
ILE A 243
None
0.82A 1uwhA-3stoA:
undetectable
1uwhA-3stoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 VAL A 681
ILE A 742
ILE A 599
ASP A 674
None
0.73A 1uwhA-3zzwA:
27.6
1uwhA-3zzwA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apw ALP12

(Clostridium
tetani)
no annotation 4 ILE A 283
VAL A 176
VAL A 116
ILE A 154
None
0.75A 1uwhA-4apwA:
undetectable
1uwhA-4apwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE


(Drosophila
melanogaster)
PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2)
4 ILE A 373
ILE A 427
ILE A 319
ASP A 402
None
0.80A 1uwhA-4c0jA:
undetectable
1uwhA-4c0jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Neurospora
crassa)
no annotation 4 ILE A 181
VAL A 143
ILE A 124
ILE A 103
None
0.79A 1uwhA-4czxA:
undetectable
1uwhA-4czxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus)
PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel)
4 ILE A 291
VAL A 290
ILE A 299
ILE A 350
None
0.81A 1uwhA-4d2iA:
undetectable
1uwhA-4d2iA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum)
PF00224
(PK)
PF02887
(PK_C)
4 ILE A 271
VAL A 292
ILE A 389
ASP A 354
None
0.65A 1uwhA-4drsA:
undetectable
1uwhA-4drsA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens)
PF01044
(Vinculin)
5 ILE A 632
VAL A 629
VAL A 390
ILE A 505
ASP A 510
None
1.32A 1uwhA-4iggA:
undetectable
1uwhA-4iggA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1


(Arabidopsis
thaliana)
PF01399
(PCI)
PF10602
(RPN7)
4 VAL A 292
VAL A 252
ILE A 325
ILE A 187
None
0.77A 1uwhA-4lctA:
2.1
1uwhA-4lctA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 ILE A 208
VAL A 171
ILE A 220
ILE A 226
AG8  A 901 (-4.3A)
None
None
None
0.82A 1uwhA-4lixA:
undetectable
1uwhA-4lixA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT


(Sulfitobacter
sp. NAS-14.1)
PF03480
(DctP)
4 ILE A 254
VAL A  50
ILE A 136
ASP A  84
None
0.83A 1uwhA-4pf8A:
undetectable
1uwhA-4pf8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora)
PF08801
(Nucleoporin_N)
4 ILE A 285
VAL A 433
ILE A 356
ILE A 446
None
0.81A 1uwhA-4q9tA:
undetectable
1uwhA-4q9tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN


(Homo sapiens)
PF00089
(Trypsin)
4 ILE A 163
VAL A 162
ILE A 103
ILE A 238
None
0.82A 1uwhA-4r0iA:
undetectable
1uwhA-4r0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE


(Homo sapiens)
PF00365
(PFK)
4 VAL A 367
VAL A 216
ILE A 174
ILE A 194
None
0.81A 1uwhA-4u1rA:
undetectable
1uwhA-4u1rA:
16.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A 150
VAL A 158
ILE A 203
ILE A 264
None
0.64A 1uwhA-4uy9A:
27.2
1uwhA-4uy9A:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1


(Rattus
norvegicus)
PF00069
(Pkinase)
4 ILE A  29
VAL A  37
ILE A  81
ASP A 165
42A  A 402 ( 4.7A)
None
None
None
0.62A 1uwhA-4xrlA:
22.3
1uwhA-4xrlA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A 165
VAL A 173
ILE A 221
ILE A 283
4E1  A 505 ( 4.6A)
4E1  A 505 (-4.5A)
None
None
0.62A 1uwhA-4yljA:
20.9
1uwhA-4yljA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE


(Haemophilus
influenzae)
PF01746
(tRNA_m1G_MT)
4 VAL A  33
VAL A  99
ILE A 133
ASP A 150
None
None
4FD  A 301 (-4.1A)
None
0.82A 1uwhA-4ypwA:
undetectable
1uwhA-4ypwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT


(Sulfurisphaera
tokodaii)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ILE A 541
VAL A 542
VAL A 436
ILE A 475
ASP A 553
None
1.42A 1uwhA-4zohA:
undetectable
1uwhA-4zohA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  61
VAL A  69
ILE A 114
ASP A 200
None
0.73A 1uwhA-4zslA:
21.2
1uwhA-4zslA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E


(Alteromonas sp.)
PF00557
(Peptidase_M24)
4 ILE A  63
VAL A  52
VAL A 149
ILE A  22
None
0.75A 1uwhA-4zwoA:
undetectable
1uwhA-4zwoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
4 ILE A  93
VAL A 298
VAL A 366
ILE A  64
None
0.80A 1uwhA-5a4jA:
undetectable
1uwhA-5a4jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2
ENTH DOMAIN OF EPSIN
ENT1


(Saccharomyces
cerevisiae)
PF01417
(ENTH)
PF07651
(ANTH)
4 ILE F 188
VAL F 252
ILE E 102
ILE E  84
None
0.77A 1uwhA-5ahvF:
undetectable
1uwhA-5ahvF:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK


(Drosophila
melanogaster)
PF00069
(Pkinase)
4 ILE A  30
VAL A  38
ILE A  83
ILE A 145
ANP  A 401 (-4.9A)
ANP  A 401 (-4.5A)
None
None
0.79A 1uwhA-5awmA:
7.0
1uwhA-5awmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
4 ILE A  69
VAL A  77
ILE A 122
ASP A 207
None
0.70A 1uwhA-5ci6A:
21.3
1uwhA-5ci6A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  22
VAL A  30
ILE A  75
ILE A 134
51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
None
None
0.71A 1uwhA-5ci7A:
23.8
1uwhA-5ci7A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
4 ILE A 555
VAL A 556
VAL A 637
ILE A 577
None
0.76A 1uwhA-5dllA:
undetectable
1uwhA-5dllA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 ILE A 848
VAL A 820
ILE A 172
ASP A  63
None
0.71A 1uwhA-5dmyA:
undetectable
1uwhA-5dmyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE


(Plasmodium
vivax)
PF00027
(cNMP_binding)
PF00069
(Pkinase)
4 ILE A 540
VAL A 548
ILE A 594
ILE A 653
4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
None
None
0.77A 1uwhA-5ezrA:
20.0
1uwhA-5ezrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42


(Saccharomyces
cerevisiae)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 VAL E  92
ILE E 141
ILE E  82
ASP E  79
None
0.82A 1uwhA-5g06E:
undetectable
1uwhA-5g06E:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE


(Caldicellulosiruptor
sp. F32)
PF00150
(Cellulase)
4 ILE A 387
VAL A  44
ILE A 137
ILE A 268
None
0.81A 1uwhA-5h4rA:
undetectable
1uwhA-5h4rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN


(Staphylococcus
aureus)
PF00459
(Inositol_P)
4 ILE A 239
VAL A  62
ILE A 104
ILE A  53
None
0.74A 1uwhA-5i3sA:
undetectable
1uwhA-5i3sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis)
PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29)
4 ILE A 177
VAL A 207
VAL A 268
ILE A 234
CL  A 402 ( 4.4A)
None
None
None
0.71A 1uwhA-5jt8A:
undetectable
1uwhA-5jt8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A 276
VAL A 284
ILE A 327
ASP A 407
IPW  A 601 (-4.0A)
IPW  A 601 (-4.2A)
None
None
0.74A 1uwhA-5kbrA:
23.7
1uwhA-5kbrA:
29.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 VAL A 827
ILE A 888
ILE A 742
ASP A 820
None
0.76A 1uwhA-5l6oA:
28.6
1uwhA-5l6oA:
32.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN


(Tribolium
castaneum)
no annotation 4 ILE A 168
VAL A 176
VAL A 219
ILE A 250
None
0.72A 1uwhA-5oatA:
20.8
1uwhA-5oatA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN


(Tribolium
castaneum)
no annotation 4 ILE A 168
VAL A 219
ILE A 250
ILE A 333
None
0.78A 1uwhA-5oatA:
20.8
1uwhA-5oatA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa)
PF16957
(Mal_decarbox_Al)
4 ILE A 222
VAL A  53
ILE A 187
ILE A  47
None
0.64A 1uwhA-5vj1A:
undetectable
1uwhA-5vj1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1


(Saccharomyces
cerevisiae)
no annotation 4 ILE G 428
VAL G 424
VAL G 300
ILE G 282
None
0.78A 1uwhA-5x6oG:
2.3
1uwhA-5x6oG:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD


(Deinococcus
radiodurans)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 ILE A 628
VAL A 402
ILE A 369
ASP A 666
None
0.82A 1uwhA-5xapA:
undetectable
1uwhA-5xapA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT


(Plasmodium
falciparum)
PF00069
(Pkinase)
4 ILE A  49
VAL A  57
ILE A  98
ILE A 156
ATP  A 403 (-4.9A)
ATP  A 403 (-3.9A)
None
None
0.58A 1uwhA-5xvuA:
21.9
1uwhA-5xvuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53


(Saccharomyces
cerevisiae)
no annotation 4 VAL A 212
VAL A 247
ILE A 256
ILE A 315
None
0.78A 1uwhA-5xzwA:
20.5
1uwhA-5xzwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5


(Homo sapiens)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
4 ILE B 267
VAL B 342
ILE B 261
ILE B 253
None
0.78A 1uwhA-5y3rB:
undetectable
1uwhA-5y3rB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9a CHORISMATE SYNTHASE

(Pseudomonas
aeruginosa)
no annotation 4 ILE A  81
VAL A  27
ILE A 150
ILE A 285
None
0.81A 1uwhA-5z9aA:
undetectable
1uwhA-5z9aA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK


(Homo sapiens)
no annotation 5 ILE A 531
VAL A 539
ILE A 585
ILE A 643
ASP A 664
CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.8A)
None
None
None
0.84A 1uwhA-6b4wA:
24.7
1uwhA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-)
no annotation 4 ILE A 173
VAL A 125
ILE A  83
ILE A 116
None
0.82A 1uwhA-6c7vA:
undetectable
1uwhA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE


(Pediculus
humanus)
no annotation 4 ILE C 165
VAL C 173
ILE C 246
ILE C 330
None
0.60A 1uwhA-6eqiC:
20.8
1uwhA-6eqiC:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE


(Pediculus
humanus)
no annotation 4 ILE C 165
VAL C 173
VAL C 216
ILE C 246
None
0.71A 1uwhA-6eqiC:
20.8
1uwhA-6eqiC:
23.94