SIMILAR PATTERNS OF AMINO ACIDS FOR 1UWH_A_BAXA1723

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.54A 1uwhA-1k9aA:
28.1		 1uwhA-1k9aA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 288
GLU A 305
THR A 334
LEU A 373
HIS A 380
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
 0.54A 1uwhA-1opkA:
26.6		 1uwhA-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 230
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.59A 1uwhA-1py5A:
25.6		 1uwhA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
 0.45A 1uwhA-1rjbA:
28.1		 1uwhA-1rjbA:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
GLU A 640
LEU A 644
THR A 670
CYH A 673
LEU A 783
HIS A 790
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
 0.57A 1uwhA-1t46A:
19.3		 1uwhA-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
GLU A  76
LEU A  80
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.73A 1uwhA-1u5qA:
24.9		 1uwhA-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  36
GLU A  55
CYH A  87
LEU A 121
HIS A 128
 HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
None
 0.52A 1uwhA-1zltA:
13.3		 1uwhA-1zltA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
 0.62A 1uwhA-1zwsA:
24.2		 1uwhA-1zwsA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 GOL  A3001 (-3.5A)
None
None
None
None
 0.45A 1uwhA-2a2aA:
24.1		 1uwhA-2a2aA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
GLU A 201
LEU A 205
LEU A 274
HIS A 281
 None
 0.65A 1uwhA-2eu9A:
22.7		 1uwhA-2eu9A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
None
None
None
 0.71A 1uwhA-2gcdA:
25.8		 1uwhA-2gcdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
LEU A  80
LEU A 142
HIS A 149
GLY A 168
 STU  A 400 (-3.2A)
None
None
None
None
None
 0.84A 1uwhA-2gcdA:
25.8		 1uwhA-2gcdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 269
GLU A 286
THR A 315
LEU A 354
HIS A 361
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
 0.55A 1uwhA-2hz0A:
28.4		 1uwhA-2hz0A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.59A 1uwhA-2j0jA:
29.2		 1uwhA-2j0jA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 BII  A1687 (-3.5A)
None
BII  A1687 (-4.1A)
None
None
BII  A1687 ( 3.9A)
 0.67A 1uwhA-2jkmA:
29.0		 1uwhA-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
THR A 663
CYH A 666
LEU A 769
HIS A 776
GLY A 795
 None
 0.52A 1uwhA-2ogvA:
27.8		 1uwhA-2ogvA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
GLU A 230
LEU A 245
THR A 265
LEU A 301
HIS A 319
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.82A 1uwhA-2qluA:
25.2		 1uwhA-2qluA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 449
GLU A 463
LEU A 467
THR A 493
LEU A 530
HIS A 537
 None
 0.66A 1uwhA-2qr7A:
20.4		 1uwhA-2qr7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
None
 0.49A 1uwhA-2w4kA:
24.0		 1uwhA-2w4kA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 445
GLU A 459
LEU A 463
THR A 489
LEU A 526
HIS A 533
 None
 0.86A 1uwhA-2wntA:
20.3		 1uwhA-2wntA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA C  76
LEU C 102
CYH C 132
LEU C 167
HIS C 174
 ANP  C   2 (-3.4A)
None
ANP  C   2 (-4.5A)
None
None
 0.65A 1uwhA-2wtkC:
23.7		 1uwhA-2wtkC:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
GLU A  66
LEU A  70
LEU A 131
HIS A 138
 J60  A1294 (-3.3A)
None
None
None
None
 0.40A 1uwhA-2xikA:
16.8		 1uwhA-2xikA:
29.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.6A)
None
None
None
None
 0.45A 1uwhA-2yabA:
24.0		 1uwhA-2yabA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.58A 1uwhA-2z2wA:
23.6		 1uwhA-2z2wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
None
None
 0.54A 1uwhA-3bqrA:
22.5		 1uwhA-3bqrA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.55A 1uwhA-3d7uA:
19.5		 1uwhA-3d7uA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  51
GLU A  71
LEU A  75
THR A 106
HIS A 148
 NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
 0.51A 1uwhA-3gp0A:
22.5		 1uwhA-3gp0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 859
GLU A 878
LEU A 882
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.45A 1uwhA-3hngA:
29.4		 1uwhA-3hngA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.55A 1uwhA-3kulA:
19.6		 1uwhA-3kulA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 700
GLU A 715
LEU A 719
CYH A 748
LEU A 788
HIS A 795
 ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.2A)
None
None
 0.59A 1uwhA-3lj0A:
23.3		 1uwhA-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA A 579
GLU A 596
LEU A 600
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.66A 1uwhA-3lltA:
21.3		 1uwhA-3lltA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
 0.59A 1uwhA-3mdyA:
24.9		 1uwhA-3mdyA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  46
GLU A  66
LEU A  70
CYH A 106
HIS A 147
 None
 0.50A 1uwhA-3mi9A:
14.5		 1uwhA-3mi9A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 227
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
None
 0.50A 1uwhA-3my0A:
24.9		 1uwhA-3my0A:
27.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 373
GLU A 393
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
 SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
 0.94A 1uwhA-3omvA:
36.3		 1uwhA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
LEU A 459
HIS A 466
GLY A 485
PHE A 475
 SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
None
None
SM5  A   1 (-3.0A)
 1.21A 1uwhA-3omvA:
36.3		 1uwhA-3omvA:
72.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ALA A  38
GLU A  58
LEU A  62
LEU A 125
HIS A 132
 None
 0.68A 1uwhA-3oz6A:
20.7		 1uwhA-3oz6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		6 ALA A  49
LEU A  82
LEU A  91
THR A 112
LEU A 149
HIS A 156
 None
 0.73A 1uwhA-3pg1A:
14.6		 1uwhA-3pg1A:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
None
None
 0.64A 1uwhA-3ppzA:
29.2		 1uwhA-3ppzA:
39.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.82A 1uwhA-3q4tA:
25.3		 1uwhA-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  84
GLU A 115
LEU A 119
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
None
None
 0.65A 1uwhA-3q5iA:
21.5		 1uwhA-3q5iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA B 616
GLU B 635
LEU B 639
CYH B 889
HIS B 933
GLY B 952
 None
 0.77A 1uwhA-3qd2B:
21.8		 1uwhA-3qd2B:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA B 616
GLU B 635
LEU B 639
HIS B 933
GLY B 952
PHE B 942
 None
 1.42A 1uwhA-3qd2B:
21.8		 1uwhA-3qd2B:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLU A 384
LEU A 397
THR A 413
LEU A 451
HIS A 458
 STU  A   1 (-3.7A)
STU  A   1 (-4.6A)
STU  A   1 (-3.9A)
None
None
 0.62A 1uwhA-3s95A:
26.3		 1uwhA-3s95A:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A 315
GLU A 334
LEU A 347
LEU A 404
HIS A 414
GLY A 433
 None
 1.02A 1uwhA-3ulzA:
22.7		 1uwhA-3ulzA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
LEU A 592
LEU A 670
HIS A 677
GLY A 696
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-3.3A)
0F4  A 902 (-4.1A)
 0.91A 1uwhA-3v5qA:
28.6		 1uwhA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 588
LEU A 592
LEU A 670
HIS A 677
GLY A 696
PHE A 698
 0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-3.3A)
0F4  A 902 (-4.1A)
 0.62A 1uwhA-3v5qA:
28.6		 1uwhA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
None
None
 0.65A 1uwhA-3vidA:
27.6		 1uwhA-3vidA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
None
 0.61A 1uwhA-3wzdA:
27.6		 1uwhA-3wzdA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwhA-4a4lA:
24.5		 1uwhA-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.2A)
None
None
 0.69A 1uwhA-4agdA:
28.8		 1uwhA-4agdA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
GLU A  51
LEU A  55
CYH A  83
HIS A 124
 D15  A 500 (-3.4A)
None
None
D15  A 500 (-4.3A)
None
 0.35A 1uwhA-4aguA:
24.8		 1uwhA-4aguA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.56A 1uwhA-4b6lA:
24.5		 1uwhA-4b6lA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
GLU A 110
LEU A 176
HIS A 183
GLY A 202
PHE A 192
 9ZP  A1333 (-3.5A)
None
None
None
9ZP  A1333 ( 4.4A)
9ZP  A1333 (-3.6A)
 1.28A 1uwhA-4b6lA:
24.5		 1uwhA-4b6lA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
GLU A  81
LEU A  85
CYH A 113
LEU A 148
HIS A 155
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-3.7A)
None
None
 0.67A 1uwhA-4bc6A:
22.3		 1uwhA-4bc6A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.37A 1uwhA-4c02A:
24.8		 1uwhA-4c02A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
GLU A 672
THR A 701
LEU A 757
HIS A 764
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
 0.82A 1uwhA-4ckrA:
28.6		 1uwhA-4ckrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  42
GLU A  61
CYH A  99
LEU A 136
HIS A 143
 None
 0.70A 1uwhA-4e3cA:
18.7		 1uwhA-4e3cA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.67A 1uwhA-4eutA:
20.5		 1uwhA-4eutA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.64A 1uwhA-4euuA:
13.8		 1uwhA-4euuA:
25.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 880
GLU A 898
LEU A 902
LEU A 967
HIS A 974
GLY A 993
 IZA  A2001 (-3.4A)
None
None
None
None
None
 1.00A 1uwhA-4gl9A:
26.4		 1uwhA-4gl9A:
30.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
GLU A 871
LEU A 875
LEU A 940
HIS A 947
 19S  A1201 (-3.3A)
None
None
None
None
 0.66A 1uwhA-4hviA:
27.2		 1uwhA-4hviA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
THR A 205
LEU A 243
HIS A 250
GLY A 269
 None
 0.64A 1uwhA-4hzsA:
26.1		 1uwhA-4hzsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.62A 1uwhA-4i6fA:
23.4		 1uwhA-4i6fA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
LEU A 196
HIS A 203
GLY A 222
PHE A 212
 1C7  A 401 (-3.2A)
None
None
None
None
1C7  A 401 (-4.0A)
 1.28A 1uwhA-4i6fA:
23.4		 1uwhA-4i6fA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 ALA A  66
GLU A  87
CYH A 119
LEU A 153
HIS A 160
GLY A 179
 None
 0.77A 1uwhA-4j7bA:
24.5		 1uwhA-4j7bA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  49
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
None
 0.67A 1uwhA-4m69A:
25.9		 1uwhA-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 388
LEU A 406
CYH A 435
LEU A 473
HIS A 480
 None
 0.57A 1uwhA-4o1oA:
16.0		 1uwhA-4o1oA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA B  51
GLU B  70
LEU B  74
LEU B 135
HIS B 142
 ADP  B 500 (-3.3A)
None
None
None
None
 0.57A 1uwhA-4o27B:
15.8		 1uwhA-4o27B:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  67
GLU A  85
THR A 123
CYH A 126
HIS A 171
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.66A 1uwhA-4o38A:
21.0		 1uwhA-4o38A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 390
LEU B 408
CYH B 437
LEU B 475
HIS B 483
 ACP  B 801 (-3.2A)
None
ACP  B 801 (-4.5A)
None
None
 0.66A 1uwhA-4oavB:
17.1		 1uwhA-4oavB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 2TT  A1202 ( 3.9A)
None
None
None
None
2TT  A1202 (-3.4A)
 0.93A 1uwhA-4oliA:
26.4		 1uwhA-4oliA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 248
THR A 301
LEU A 338
HIS A 347
GLY A 367
PHE A 356
 None
 1.45A 1uwhA-4pwnA:
3.6		 1uwhA-4pwnA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.36A 1uwhA-4rt7A:
18.9		 1uwhA-4rt7A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.48A 1uwhA-4xufA:
28.6		 1uwhA-4xufA:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
GLU A 509
LEU A 513
THR A 539
LEU A 577
HIS A 586
 4CV  A 801 (-3.5A)
None
None
4CV  A 801 (-2.8A)
None
None
 0.64A 1uwhA-4yffA:
26.9		 1uwhA-4yffA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  55
GLU A  76
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-3.3A)
None
None
ADP  A 506 ( 4.6A)
None
 0.57A 1uwhA-4ysjA:
24.6		 1uwhA-4ysjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 597
GLU A 612
LEU A 616
CYH A 645
LEU A 679
HIS A 686
 None
 0.67A 1uwhA-4z7gA:
20.9		 1uwhA-4z7gA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		6 ALA A 338
GLU A 179
LEU A 175
LEU A 379
THR A 342
GLY A 380
 None
 1.39A 1uwhA-5e3xA:
undetectable		 1uwhA-5e3xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
GLU A 290
LEU A 305
THR A 325
LEU A 361
HIS A 377
 STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
None
 0.81A 1uwhA-5e8yA:
24.9		 1uwhA-5e8yA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 5U3  A1200 (-3.5A)
None
None
None
None
5U3  A1200 ( 4.9A)
 1.00A 1uwhA-5f1zA:
26.1		 1uwhA-5f1zA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 481
LEU A 514
THR A 529
TRP A 531
CYH A 532
LEU A 567
HIS A 574
GLY A 593
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
None
5XJ  A 801 ( 3.7A)
 0.54A 1uwhA-5fd2A:
36.5		 1uwhA-5fd2A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 481
LEU A 514
THR A 529
TRP A 531
LEU A 567
HIS A 574
GLY A 593
PHE A 583
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
None
None
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-4.3A)
 1.16A 1uwhA-5fd2A:
36.5		 1uwhA-5fd2A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.51A 1uwhA-5grnA:
18.6		 1uwhA-5grnA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.54A 1uwhA-5j5tA:
21.7		 1uwhA-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.82A 1uwhA-5jznA:
23.7		 1uwhA-5jznA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA B 690
THR B 739
CYH B 742
LEU B 777
HIS B 784
 6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
None
None
 0.55A 1uwhA-5kkrB:
18.7		 1uwhA-5kkrB:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 228
GLU A 250
LEU A 263
CYH A 286
LEU A 320
HIS A 329
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.3A)
None
6UY  A 501 (-4.3A)
None
None
 0.93A 1uwhA-5ko1A:
26.9		 1uwhA-5ko1A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 ALA A 174
THR A 227
LEU A 264
HIS A 273
GLY A 293
PHE A 282
 GOL  A 604 ( 3.8A)
GOL  A 604 (-3.9A)
None
None
GOL  A 604 ( 4.6A)
GOL  A 604 ( 4.5A)
 1.33A 1uwhA-5o2cA:
25.4		 1uwhA-5o2cA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 ALA A  38
GLU A  57
LEU A  61
CYH A  89
HIS A 130
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.3A)
None
 0.69A 1uwhA-5tvtA:
23.7		 1uwhA-5tvtA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.65A 1uwhA-5vcxA:
22.7		 1uwhA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 137
THR A 187
LEU A 224
HIS A 231
GLY A 250
PHE A 240
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
None
None
None
H8H  A 401 (-4.3A)
 1.33A 1uwhA-5vcxA:
22.7		 1uwhA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 ALA A  49
GLU A  69
LEU A  82
LEU A 132
HIS A 141
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
VX6  A 402 ( 4.8A)
None
None
 0.51A 1uwhA-5wnmA:
29.1		 1uwhA-5wnmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 ALA A 917
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.68A 1uwhA-5wnoA:
25.1		 1uwhA-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 107
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.6A)
None
None
None
None
 0.53A 1uwhA-5xv7A:
21.0		 1uwhA-5xv7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 ALA A 906
GLU A 925
LEU A 929
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-3.4A)
None
None
None
None
None
 0.90A 1uwhA-6c7yA:
26.0		 1uwhA-6c7yA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 ALA A 715
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.73A 1uwhA-6cnhA:
21.8		 1uwhA-6cnhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.51A 1uwhA-6cz4A:
27.2		 1uwhA-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 ALA A 191
GLU A 208
LEU A 212
LEU A 281
HIS A 288
 3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
 0.52A 1uwhA-6fylA:
22.6		 1uwhA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 ALA A 189
GLU A 206
LEU A 210
LEU A 279
HIS A 286
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
None
 0.68A 1uwhA-6fyvA:
22.5		 1uwhA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		4 VAL A 113
VAL A 163
ILE A 140
ILE A  50
 None
 0.82A 1uwhA-1f3gA:
undetectable		 1uwhA-1f3gA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 ILE D 196
VAL D  68
ILE D 138
ILE D  89
 None
 0.77A 1uwhA-1g0uD:
undetectable		 1uwhA-1g0uD:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  62
VAL A  70
ILE A 109
ILE A 177
 None
 0.57A 1uwhA-1gngA:
21.8		 1uwhA-1gngA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC

(Thermotoga
maritima) 		PF03775
(MinC_C) 		4 ILE A  62
VAL A  63
VAL A 122
ILE A 148
 None
 0.79A 1uwhA-1hf2A:
undetectable		 1uwhA-1hf2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 236
VAL A 284
ILE A 175
ILE A 286
 None
 0.70A 1uwhA-1hygA:
undetectable		 1uwhA-1hygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Weissella
confusa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 290
VAL A 263
VAL A  50
ILE A  27
 None
 0.76A 1uwhA-1hyhA:
undetectable		 1uwhA-1hyhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 205
VAL A 251
ILE A 289
ILE A 168
 None
 0.71A 1uwhA-1k4qA:
undetectable		 1uwhA-1k4qA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 VAL T 251
VAL T  36
ILE T  13
ILE T  72
 None
 0.64A 1uwhA-1lthT:
undetectable		 1uwhA-1lthT:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 ILE A 211
VAL A 219
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
None
None
 0.64A 1uwhA-1py5A:
25.6		 1uwhA-1py5A:
29.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 603
VAL A 643
ILE A 653
ASP A 810
 STI  A   3 ( 4.6A)
None
None
STI  A   3 (-3.9A)
 0.69A 1uwhA-1t46A:
19.3		 1uwhA-1t46A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		4 ILE A 110
VAL A 111
ILE A 309
ASP A  92
 None
 0.77A 1uwhA-1u7nA:
undetectable		 1uwhA-1u7nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 ILE A 215
ILE A 327
ILE A 290
ASP A 247
 None
 0.76A 1uwhA-1v5cA:
undetectable		 1uwhA-1v5cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		4 ILE A 111
VAL A 112
ILE A 307
ASP A  93
 None
 0.73A 1uwhA-1vi1A:
undetectable		 1uwhA-1vi1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 285
ILE A 212
ILE A 154
ASP A 215
 None
None
None
CO  A1003 (-2.8A)
 0.78A 1uwhA-1wn1A:
undetectable		 1uwhA-1wn1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		4 ILE A 356
VAL A 360
ILE A 238
ASP A 313
 None
 0.76A 1uwhA-1x1nA:
undetectable		 1uwhA-1x1nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhA-1z7eA:
undetectable		 1uwhA-1z7eA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		5 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 0.95A 1uwhA-1zdrA:
undetectable		 1uwhA-1zdrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		4 ILE A 134
VAL A 130
ILE A  87
ILE A  52
 None
 0.75A 1uwhA-2hj0A:
undetectable		 1uwhA-2hj0A:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 428
VAL A 436
ILE A 483
ASP A 564
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
None
None
 0.67A 1uwhA-2jkmA:
29.0		 1uwhA-2jkmA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A 278
VAL A 197
ILE A 184
ASP A 163
 None
 0.78A 1uwhA-2og2A:
undetectable		 1uwhA-2og2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 813
ILE A 874
ILE A 730
ASP A 806
 None
 0.77A 1uwhA-2qobA:
28.7		 1uwhA-2qobA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ILE A 681
VAL A 689
ILE A 736
ASP A 818
 None
 0.70A 1uwhA-2r2pA:
28.7		 1uwhA-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 867
ILE A 928
ILE A 784
ASP A 860
 None
 0.77A 1uwhA-2r2pA:
28.7		 1uwhA-2r2pA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 713
VAL A1013
ILE A1006
ILE A1021
 None
 0.78A 1uwhA-2vdcA:
undetectable		 1uwhA-2vdcA:
11.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 627
VAL A 635
ILE A 682
ASP A 764
 None
Q9G  A1898 ( 4.7A)
None
None
 0.66A 1uwhA-2xyuA:
29.4		 1uwhA-2xyuA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  30
VAL A  38
ILE A  90
ILE A 149
 B49  A1294 (-3.9A)
None
None
None
 0.73A 1uwhA-2y7jA:
15.7		 1uwhA-2y7jA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 825
ILE A 886
ILE A 742
ASP A 818
 None
 0.75A 1uwhA-3dkoA:
28.5		 1uwhA-3dkoA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 150
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
None
None
VIN  A6331 (-4.0A)
 0.70A 1uwhA-3dtcA:
27.5		 1uwhA-3dtcA:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 150
VAL A 158
ILE A 203
ILE A 264
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
None
None
 0.66A 1uwhA-3dtcA:
27.5		 1uwhA-3dtcA:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  32
VAL A  40
ILE A  85
ILE A 147
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
None
None
 0.75A 1uwhA-3e7oA:
20.6		 1uwhA-3e7oA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A  34
VAL A  42
ILE A  85
ASP A 169
 DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
None
None
 0.74A 1uwhA-3f3zA:
14.7		 1uwhA-3f3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ILE A 133
VAL A 150
ILE A  84
ILE A  50
 None
 0.79A 1uwhA-3f9kA:
undetectable		 1uwhA-3f9kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  62
VAL A  70
ILE A 115
ILE A 174
 None
 0.66A 1uwhA-3fe3A:
23.2		 1uwhA-3fe3A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 209
VAL A 217
ILE A 257
ILE A 329
 ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
None
None
 0.66A 1uwhA-3g2fA:
24.8		 1uwhA-3g2fA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		4 ILE A 102
VAL A  80
VAL A 240
ILE A 161
 None
None
None
EDO  A 255 (-4.5A)
 0.71A 1uwhA-3ggdA:
undetectable		 1uwhA-3ggdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		4 ILE A 964
VAL A 938
VAL A 804
ILE A 820
 None
 0.81A 1uwhA-3hx6A:
undetectable		 1uwhA-3hx6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00579
(tRNA-synt_1b) 		4 ILE A 168
VAL A 165
ILE A 110
ILE A 136
 None
 0.79A 1uwhA-3i05A:
undetectable		 1uwhA-3i05A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4s HISTIDINE TRIAD
PROTEIN

(Bradyrhizobium
japonicum) 		PF01230
(HIT) 		4 VAL A 144
VAL A 101
ILE A 108
ILE A 169
 None
 0.69A 1uwhA-3i4sA:
3.0		 1uwhA-3i4sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 209
VAL A 217
ILE A 244
ILE A 123
 None
 0.69A 1uwhA-3icsA:
undetectable		 1uwhA-3icsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  59
VAL A  67
ILE A 112
ASP A 193
 None
 0.68A 1uwhA-3iecA:
23.6		 1uwhA-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A  59
VAL A  67
ILE A 112
ILE A 171
 None
 0.79A 1uwhA-3iecA:
23.6		 1uwhA-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		4 VAL A 130
ILE A 221
ILE A 214
ASP A 194
 None
 0.71A 1uwhA-3k6rA:
undetectable		 1uwhA-3k6rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 ILE A  63
VAL A  52
VAL A 149
ILE A  22
 None
 0.70A 1uwhA-3l7gA:
undetectable		 1uwhA-3l7gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  76
VAL A 112
ILE A 121
ILE A 180
 ANP  A 522 (-4.1A)
None
None
None
 0.44A 1uwhA-3lijA:
24.8		 1uwhA-3lijA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A  75
VAL A 401
VAL A 502
ILE A 518
 None
 0.74A 1uwhA-3ljpA:
undetectable		 1uwhA-3ljpA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		4 VAL A 359
VAL A 455
ILE A 429
ILE A 450
 None
 0.72A 1uwhA-3m99A:
undetectable		 1uwhA-3m99A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 ILE A 357
VAL A 358
ILE A 367
ILE A  27
ASP A 374
 None
 0.97A 1uwhA-3n2cA:
undetectable		 1uwhA-3n2cA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 VAL A 548
VAL A 397
ILE A 355
ILE A 375
 None
None
F6P  A 988 (-4.9A)
None
 0.80A 1uwhA-3o8oA:
undetectable		 1uwhA-3o8oA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 VAL B 541
VAL B 389
ILE B 347
ILE B 367
 None
 0.83A 1uwhA-3o8oB:
undetectable		 1uwhA-3o8oB:
17.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 355
VAL A 363
VAL A 396
ILE A 405
ILE A 464
 SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
None
None
None
 0.53A 1uwhA-3omvA:
36.4		 1uwhA-3omvA:
72.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 VAL A 574
VAL A 538
ILE A 682
ASP A 516
 None
 0.75A 1uwhA-3psiA:
undetectable		 1uwhA-3psiA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 206
VAL A 235
ILE A 246
ILE A 318
 TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
None
None
 0.55A 1uwhA-3q4tA:
25.3		 1uwhA-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 ILE A  46
VAL A 256
ILE A 382
ILE A 243
 None
 0.82A 1uwhA-3stoA:
undetectable		 1uwhA-3stoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 681
ILE A 742
ILE A 599
ASP A 674
 None
 0.73A 1uwhA-3zzwA:
27.6		 1uwhA-3zzwA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apw ALP12

(Clostridium
tetani) 		no annotation 4 ILE A 283
VAL A 176
VAL A 116
ILE A 154
 None
 0.75A 1uwhA-4apwA:
undetectable		 1uwhA-4apwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE

(Drosophila
melanogaster) 		PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		4 ILE A 373
ILE A 427
ILE A 319
ASP A 402
 None
 0.80A 1uwhA-4c0jA:
undetectable		 1uwhA-4c0jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 4 ILE A 181
VAL A 143
ILE A 124
ILE A 103
 None
 0.79A 1uwhA-4czxA:
undetectable		 1uwhA-4czxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 ILE A 291
VAL A 290
ILE A 299
ILE A 350
 None
 0.81A 1uwhA-4d2iA:
undetectable		 1uwhA-4d2iA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		4 ILE A 271
VAL A 292
ILE A 389
ASP A 354
 None
 0.65A 1uwhA-4drsA:
undetectable		 1uwhA-4drsA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 ILE A 632
VAL A 629
VAL A 390
ILE A 505
ASP A 510
 None
 1.32A 1uwhA-4iggA:
undetectable		 1uwhA-4iggA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		4 VAL A 292
VAL A 252
ILE A 325
ILE A 187
 None
 0.77A 1uwhA-4lctA:
2.1		 1uwhA-4lctA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 208
VAL A 171
ILE A 220
ILE A 226
 AG8  A 901 (-4.3A)
None
None
None
 0.82A 1uwhA-4lixA:
undetectable		 1uwhA-4lixA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		4 ILE A 254
VAL A  50
ILE A 136
ASP A  84
 None
 0.83A 1uwhA-4pf8A:
undetectable		 1uwhA-4pf8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		4 ILE A 285
VAL A 433
ILE A 356
ILE A 446
 None
 0.81A 1uwhA-4q9tA:
undetectable		 1uwhA-4q9tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 163
VAL A 162
ILE A 103
ILE A 238
 None
 0.82A 1uwhA-4r0iA:
undetectable		 1uwhA-4r0iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 VAL A 367
VAL A 216
ILE A 174
ILE A 194
 None
 0.81A 1uwhA-4u1rA:
undetectable		 1uwhA-4u1rA:
16.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 150
VAL A 158
ILE A 203
ILE A 264
 None
 0.64A 1uwhA-4uy9A:
27.2		 1uwhA-4uy9A:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 ILE A  29
VAL A  37
ILE A  81
ASP A 165
 42A  A 402 ( 4.7A)
None
None
None
 0.62A 1uwhA-4xrlA:
22.3		 1uwhA-4xrlA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 165
VAL A 173
ILE A 221
ILE A 283
 4E1  A 505 ( 4.6A)
4E1  A 505 (-4.5A)
None
None
 0.62A 1uwhA-4yljA:
20.9		 1uwhA-4yljA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Haemophilus
influenzae) 		PF01746
(tRNA_m1G_MT) 		4 VAL A  33
VAL A  99
ILE A 133
ASP A 150
 None
None
4FD  A 301 (-4.1A)
None
 0.82A 1uwhA-4ypwA:
undetectable		 1uwhA-4ypwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE A 541
VAL A 542
VAL A 436
ILE A 475
ASP A 553
 None
 1.42A 1uwhA-4zohA:
undetectable		 1uwhA-4zohA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  61
VAL A  69
ILE A 114
ASP A 200
 None
 0.73A 1uwhA-4zslA:
21.2		 1uwhA-4zslA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 ILE A  63
VAL A  52
VAL A 149
ILE A  22
 None
 0.75A 1uwhA-4zwoA:
undetectable		 1uwhA-4zwoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 ILE A  93
VAL A 298
VAL A 366
ILE A  64
 None
 0.80A 1uwhA-5a4jA:
undetectable		 1uwhA-5a4jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2
ENTH DOMAIN OF EPSIN
ENT1

(Saccharomyces
cerevisiae) 		PF01417
(ENTH)
PF07651
(ANTH) 		4 ILE F 188
VAL F 252
ILE E 102
ILE E  84
 None
 0.77A 1uwhA-5ahvF:
undetectable		 1uwhA-5ahvF:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 ILE A  30
VAL A  38
ILE A  83
ILE A 145
 ANP  A 401 (-4.9A)
ANP  A 401 (-4.5A)
None
None
 0.79A 1uwhA-5awmA:
7.0		 1uwhA-5awmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ILE A  69
VAL A  77
ILE A 122
ASP A 207
 None
 0.70A 1uwhA-5ci6A:
21.3		 1uwhA-5ci6A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  22
VAL A  30
ILE A  75
ILE A 134
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
None
None
 0.71A 1uwhA-5ci7A:
23.8		 1uwhA-5ci7A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 555
VAL A 556
VAL A 637
ILE A 577
 None
 0.76A 1uwhA-5dllA:
undetectable		 1uwhA-5dllA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 848
VAL A 820
ILE A 172
ASP A  63
 None
 0.71A 1uwhA-5dmyA:
undetectable		 1uwhA-5dmyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ILE A 540
VAL A 548
ILE A 594
ILE A 653
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
None
None
 0.77A 1uwhA-5ezrA:
20.0		 1uwhA-5ezrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL E  92
ILE E 141
ILE E  82
ASP E  79
 None
 0.82A 1uwhA-5g06E:
undetectable		 1uwhA-5g06E:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		4 ILE A 387
VAL A  44
ILE A 137
ILE A 268
 None
 0.81A 1uwhA-5h4rA:
undetectable		 1uwhA-5h4rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		4 ILE A 239
VAL A  62
ILE A 104
ILE A  53
 None
 0.74A 1uwhA-5i3sA:
undetectable		 1uwhA-5i3sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 ILE A 177
VAL A 207
VAL A 268
ILE A 234
 CL  A 402 ( 4.4A)
None
None
None
 0.71A 1uwhA-5jt8A:
undetectable		 1uwhA-5jt8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 276
VAL A 284
ILE A 327
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.2A)
None
None
 0.74A 1uwhA-5kbrA:
23.7		 1uwhA-5kbrA:
29.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 827
ILE A 888
ILE A 742
ASP A 820
 None
 0.76A 1uwhA-5l6oA:
28.6		 1uwhA-5l6oA:
32.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 ILE A 168
VAL A 176
VAL A 219
ILE A 250
 None
 0.72A 1uwhA-5oatA:
20.8		 1uwhA-5oatA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 ILE A 168
VAL A 219
ILE A 250
ILE A 333
 None
 0.78A 1uwhA-5oatA:
20.8		 1uwhA-5oatA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 ILE A 222
VAL A  53
ILE A 187
ILE A  47
 None
 0.64A 1uwhA-5vj1A:
undetectable		 1uwhA-5vj1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE G 428
VAL G 424
VAL G 300
ILE G 282
 None
 0.78A 1uwhA-5x6oG:
2.3		 1uwhA-5x6oG:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 ILE A 628
VAL A 402
ILE A 369
ASP A 666
 None
 0.82A 1uwhA-5xapA:
undetectable		 1uwhA-5xapA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ILE A  49
VAL A  57
ILE A  98
ILE A 156
 ATP  A 403 (-4.9A)
ATP  A 403 (-3.9A)
None
None
 0.58A 1uwhA-5xvuA:
21.9		 1uwhA-5xvuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 212
VAL A 247
ILE A 256
ILE A 315
 None
 0.78A 1uwhA-5xzwA:
20.5		 1uwhA-5xzwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 ILE B 267
VAL B 342
ILE B 261
ILE B 253
 None
 0.78A 1uwhA-5y3rB:
undetectable		 1uwhA-5y3rB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9a CHORISMATE SYNTHASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A  81
VAL A  27
ILE A 150
ILE A 285
 None
 0.81A 1uwhA-5z9aA:
undetectable		 1uwhA-5z9aA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 5 ILE A 531
VAL A 539
ILE A 585
ILE A 643
ASP A 664
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.8A)
None
None
None
 0.84A 1uwhA-6b4wA:
24.7		 1uwhA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 4 ILE A 173
VAL A 125
ILE A  83
ILE A 116
 None
 0.82A 1uwhA-6c7vA:
undetectable		 1uwhA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 4 ILE C 165
VAL C 173
ILE C 246
ILE C 330
 None
 0.60A 1uwhA-6eqiC:
20.8		 1uwhA-6eqiC:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 4 ILE C 165
VAL C 173
VAL C 216
ILE C 246
 None
 0.71A 1uwhA-6eqiC:
20.8		 1uwhA-6eqiC:
23.94