SIMILAR PATTERNS OF AMINO ACIDS FOR 1UW6_L_NCTL1206

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 TYR A 170
CYH A 155
TRP A 174
MET A 395
 None
None
SO4  A 501 (-4.9A)
None
 1.50A 1uw6L-1ff9A:
0.0
1uw6M-1ff9A:
0.0		 1uw6L-1ff9A:
20.05
1uw6M-1ff9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN

(Prochlorococcus
phage P-SSM2) 		PF05996
(Fe_bilin_red) 		4 TYR A  27
CYH A 159
TYR A 167
TRP A  24
 None
 1.40A 1uw6L-2vclA:
0.0
1uw6M-2vclA:
0.0		 1uw6L-2vclA:
20.83
1uw6M-2vclA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 TYR A 190
CYH A 413
TYR A  23
TRP A 469
 GOL  A 485 (-4.4A)
None
None
None
 1.42A 1uw6L-3n6xA:
0.0
1uw6M-3n6xA:
0.0		 1uw6L-3n6xA:
17.58
1uw6M-3n6xA:
17.58