SIMILAR PATTERNS OF AMINO ACIDS FOR 1UUJ_B_ACTB1077_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		3 ARG A 169
TYR A 161
LYS A 160
 None
 0.98A 1uujB-1b0zA:
0.0		 1uujB-1b0zA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00769
(ERM) 		3 ARG C 508
TYR C 556
LYS C 555
 None
 1.01A 1uujB-1ef1C:
undetectable		 1uujB-1ef1C:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlv MAJOR CENTROMERE
AUTOANTIGEN B

(Homo sapiens) 		PF03221
(HTH_Tnp_Tc5)
PF04218
(CENP-B_N) 		3 ARG A  66
TYR A  59
LYS A  58
 None
 0.99A 1uujB-1hlvA:
1.0		 1uujB-1hlvA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		3 ARG A 204
TYR A 243
LYS A 242
 None
 0.81A 1uujB-1hm6A:
0.0		 1uujB-1hm6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		3 ARG A  32
TYR A  22
LYS A  21
 None
 1.07A 1uujB-1htdA:
0.0		 1uujB-1htdA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 ARG A  34
TYR A  24
LYS A  23
 None
 0.97A 1uujB-1kugA:
0.0		 1uujB-1kugA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		3 ARG A 512
TYR A 546
LYS A 545
 None
 0.84A 1uujB-1n11A:
undetectable		 1uujB-1n11A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		3 ARG A  32
TYR A  22
LYS A  21
 None
 0.97A 1uujB-1nd1A:
0.0		 1uujB-1nd1A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 ARG A 155
TYR A 481
LYS A 229
 None
 0.96A 1uujB-1nj1A:
undetectable		 1uujB-1nj1A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ARG A 185
TYR A 173
LYS A   3
 None
 0.85A 1uujB-1rxwA:
0.0		 1uujB-1rxwA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suj CONE ARRESTIN

(Ambystoma
tigrinum) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		3 ARG A  24
TYR A   8
LYS A   6
 None
 0.85A 1uujB-1sujA:
undetectable		 1uujB-1sujA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5l PRION PROTEIN

(Trachemys
scripta) 		PF00377
(Prion) 		3 ARG A 175
TYR A 166
LYS A 164
 None
 0.67A 1uujB-1u5lA:
undetectable		 1uujB-1u5lA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		3 ARG A 305
TYR A 262
LYS A 266
 None
 0.78A 1uujB-1us4A:
undetectable		 1uujB-1us4A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpm ACYL-COA HYDROLASE

(Bacillus
halodurans) 		PF03061
(4HBT) 		3 ARG A  16
TYR A  37
LYS A  33
 None
 0.68A 1uujB-1vpmA:
undetectable		 1uujB-1vpmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		3 ARG A  32
TYR A  22
LYS A  21
 None
 0.95A 1uujB-1wniA:
undetectable		 1uujB-1wniA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 ARG A 234
TYR A 229
LYS A 227
 None
 0.97A 1uujB-1wznA:
undetectable		 1uujB-1wznA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		3 ARG A  68
TYR A  18
LYS A  20
 None
 1.01A 1uujB-1xqwA:
undetectable		 1uujB-1xqwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		3 ARG 1 268
TYR 1 280
LYS 1 284
 None
 0.81A 1uujB-1y791:
1.0		 1uujB-1y791:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		3 ARG A 103
TYR A 125
LYS A 121
 None
 0.92A 1uujB-1ybdA:
undetectable		 1uujB-1ybdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		3 ARG E 156
TYR E 179
LYS E 178
 None
 0.79A 1uujB-1z5yE:
undetectable		 1uujB-1z5yE:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		3 ARG A  64
TYR A  36
LYS A  40
 None
 0.72A 1uujB-1z9aA:
undetectable		 1uujB-1z9aA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 225
TYR A  32
LYS A  31
 None
 0.99A 1uujB-2d1qA:
undetectable		 1uujB-2d1qA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 515
TYR A 446
LYS A 447
 None
 0.97A 1uujB-2d1qA:
undetectable		 1uujB-2d1qA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		3 ARG A 342
TYR A 311
LYS A 315
 None
 0.68A 1uujB-2e7jA:
undetectable		 1uujB-2e7jA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 ARG A 225
TYR A 215
LYS A 214
 None
 0.98A 1uujB-2erqA:
undetectable		 1uujB-2erqA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 ARG A 493
TYR A 462
LYS A 460
 None
 0.69A 1uujB-2fvmA:
undetectable		 1uujB-2fvmA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igi OLIGORIBONUCLEASE

(Escherichia
coli) 		PF00929
(RNase_T) 		3 ARG A  23
TYR A 118
LYS A 117
 None
 0.97A 1uujB-2igiA:
undetectable		 1uujB-2igiA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 ARG A 178
TYR A 148
LYS A 152
 None
 0.80A 1uujB-2j0jA:
undetectable		 1uujB-2j0jA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0r HEMIN TRANSPORT
PROTEIN HEMS

(Yersinia
enterocolitica) 		PF05171
(HemS) 		3 ARG A  39
TYR A   9
LYS A  13
 None
 0.92A 1uujB-2j0rA:
undetectable		 1uujB-2j0rA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4n PROTEIN PF0246

(Pyrococcus
furiosus) 		no annotation 3 ARG A  85
TYR A  77
LYS A  44
 None
 1.01A 1uujB-2k4nA:
undetectable		 1uujB-2k4nA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsj DNA REPAIR PROTEIN
REV1

(Mus musculus) 		PF16727
(REV1_C) 		3 ARG A  83
TYR A  80
LYS A  37
 None
 0.97A 1uujB-2lsjA:
undetectable		 1uujB-2lsjA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		3 ARG A 221
TYR A 183
LYS A 187
 None
 1.03A 1uujB-2oodA:
undetectable		 1uujB-2oodA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 ARG A 322
TYR A 329
LYS A 333
 None
 0.99A 1uujB-2pxjA:
undetectable		 1uujB-2pxjA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ARG A 121
TYR A 184
LYS A 188
 None
 0.86A 1uujB-2qp4A:
undetectable		 1uujB-2qp4A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfk SMALL NUCLEOLAR RNP
SIMILAR TO GAR1

(Pyrococcus
furiosus) 		PF04410
(Gar1) 		3 ARG C   3
TYR C  71
LYS C  33
 None
 1.07A 1uujB-2rfkC:
undetectable		 1uujB-2rfkC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 144
TYR A 287
LYS A 283
 None
 0.76A 1uujB-2rgwA:
undetectable		 1uujB-2rgwA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkt CTP SYNTHASE 2

(Homo sapiens) 		PF00117
(GATase) 		3 ARG A 311
TYR A 307
LYS A 306
 None
 0.88A 1uujB-2vktA:
undetectable		 1uujB-2vktA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 ARG A 147
TYR A 223
LYS A 222
 None
 0.95A 1uujB-2yijA:
undetectable		 1uujB-2yijA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 203
TYR A 170
LYS A 174
 None
 1.00A 1uujB-2zc8A:
undetectable		 1uujB-2zc8A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ARG O 382
TYR O 474
LYS O 478
 None
 1.03A 1uujB-2zf5O:
1.4		 1uujB-2zf5O:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		3 ARG A 762
TYR A 662
LYS A 666
 None
 0.83A 1uujB-3a6pA:
undetectable		 1uujB-3a6pA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		3 ARG A 218
TYR A 182
LYS A 186
 None
 0.35A 1uujB-3d1cA:
undetectable		 1uujB-3d1cA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcz PUTATIVE RNFG
SUBUNIT OF ELECTRON
TRANSPORT COMPLEX

(Thermotoga
maritima) 		PF04205
(FMN_bind) 		3 ARG A 217
TYR A  81
LYS A  79
 None
 0.92A 1uujB-3dczA:
undetectable		 1uujB-3dczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		3 ARG A 154
TYR A 156
LYS A 142
 SO4  A 222 (-3.2A)
SO4  A 222 (-4.6A)
SO4  A 222 (-2.7A)
 1.05A 1uujB-3e23A:
undetectable		 1uujB-3e23A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		3 ARG A  36
TYR A  83
LYS A  82
 None
 1.07A 1uujB-3f8rA:
undetectable		 1uujB-3f8rA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF08996
(zf-DNA_Pol) 		3 ARG B1335
TYR B1448
LYS B1447
 None
 1.03A 1uujB-3floB:
undetectable		 1uujB-3floB:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		3 ARG A 585
TYR A 587
LYS A 399
 None
 0.98A 1uujB-3fqdA:
undetectable		 1uujB-3fqdA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		3 ARG A 516
TYR A 513
LYS A 625
 DCP  A 101 (-2.9A)
DCP  A 101 (-4.7A)
DCP  A 101 (-2.9A)
 1.00A 1uujB-3gqcA:
undetectable		 1uujB-3gqcA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		3 ARG A1372
TYR A1368
LYS A1305
 None
 1.06A 1uujB-3hrrA:
0.5		 1uujB-3hrrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli) 		PF00480
(ROK) 		3 ARG A 228
TYR A 266
LYS A 265
 None
 1.01A 1uujB-3htvA:
undetectable		 1uujB-3htvA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzz TYPE IV PILIN
STRUCTURAL SUBUNIT

(Pseudomonas
aeruginosa) 		PF00114
(Pilin) 		3 ARG A  32
TYR A  78
LYS A  77
 None
 0.92A 1uujB-3jzzA:
undetectable		 1uujB-3jzzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		3 ARG A 346
TYR A 259
LYS A 263
 None
 0.90A 1uujB-3my7A:
0.8		 1uujB-3my7A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1g BROTHER OF CDO

(Homo sapiens) 		PF00041
(fn3) 		3 ARG C 753
TYR C 763
LYS C 789
 None
 1.07A 1uujB-3n1gC:
undetectable		 1uujB-3n1gC:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ARG A  58
TYR A 449
LYS A 450
 None
 1.01A 1uujB-3ng0A:
undetectable		 1uujB-3ng0A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		3 ARG A  90
TYR A 165
LYS A 169
 GOL  A 278 (-3.4A)
NHE  A 276 (-4.7A)
NHE  A 276 ( 4.7A)
 0.89A 1uujB-3nibA:
undetectable		 1uujB-3nibA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ARG A 432
TYR A 320
LYS A 322
 None
 0.88A 1uujB-3rj8A:
undetectable		 1uujB-3rj8A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		3 ARG A 232
TYR A 241
LYS A 422
 None
None
NDP  A 801 ( 4.1A)
 1.03A 1uujB-3slkA:
undetectable		 1uujB-3slkA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ARG A 366
TYR A 193
LYS A 187
 None
 1.01A 1uujB-3ss6A:
undetectable		 1uujB-3ss6A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		3 ARG B 325
TYR B 290
LYS B 294
 None
 0.76A 1uujB-3ufxB:
undetectable		 1uujB-3ufxB:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		3 ARG A 132
TYR A 137
LYS A 141
 None
 0.98A 1uujB-3v4yA:
undetectable		 1uujB-3v4yA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		3 ARG A 147
TYR A 104
LYS A 108
 None
 0.87A 1uujB-3wg6A:
undetectable		 1uujB-3wg6A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		3 ARG A  32
TYR A  22
LYS A  21
 None
 1.00A 1uujB-4aigA:
undetectable		 1uujB-4aigA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		3 ARG A 232
TYR A 236
LYS A 240
 None
 1.06A 1uujB-4aurA:
1.6		 1uujB-4aurA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE

(Physcomitrella
patens) 		PF01507
(PAPS_reduct) 		3 ARG A 131
TYR A 264
LYS A 263
 None
 1.01A 1uujB-4bwvA:
undetectable		 1uujB-4bwvA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		3 ARG A  77
TYR A 106
LYS A 105
 None
 0.96A 1uujB-4c1lA:
undetectable		 1uujB-4c1lA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		3 ARG A 178
TYR A 142
LYS A 305
 SO4  A 504 (-4.5A)
SO4  A 504 (-4.7A)
SO4  A 504 (-2.8A)
 0.86A 1uujB-4eogA:
undetectable		 1uujB-4eogA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoy MICROTUBULE-ASSOCIAT
ED PROTEIN 1 LIGHT
CHAIN 3

(Plasmodium
falciparum) 		PF02991
(Atg8) 		3 ARG A  22
TYR A 104
LYS A 108
 None
 1.07A 1uujB-4eoyA:
undetectable		 1uujB-4eoyA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		3 ARG A 388
TYR A 349
LYS A 353
 None
 0.89A 1uujB-4eppA:
undetectable		 1uujB-4eppA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		3 ARG A 140
TYR A 120
LYS A 124
 ACT  A 601 (-3.2A)
None
ACT  A 601 (-3.1A)
 0.70A 1uujB-4f53A:
0.0		 1uujB-4f53A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		3 ARG A 253
TYR A 287
LYS A 319
 None
 1.03A 1uujB-4h3sA:
undetectable		 1uujB-4h3sA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 220
TYR A 276
LYS A 272
 None
 0.90A 1uujB-4hozA:
undetectable		 1uujB-4hozA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 ARG C 195
TYR C 152
LYS C 156
 None
 0.74A 1uujB-4i99C:
undetectable		 1uujB-4i99C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		3 ARG D 697
TYR D 699
LYS D 677
 None
 1.06A 1uujB-4j3oD:
undetectable		 1uujB-4j3oD:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 ARG A  34
TYR A  24
LYS A  23
 None
 0.97A 1uujB-4j4mA:
undetectable		 1uujB-4j4mA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		3 ARG A 678
TYR A 518
LYS A 519
 None
 1.00A 1uujB-4oonA:
undetectable		 1uujB-4oonA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe6 PUTATIVE ABC
TRANSPORTER

(Thermobispora
bispora) 		PF13407
(Peripla_BP_4) 		3 ARG A 182
TYR A 194
LYS A 198
 None
 0.97A 1uujB-4pe6A:
undetectable		 1uujB-4pe6A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		3 ARG B 352
TYR B  14
LYS B  18
 None
 0.99A 1uujB-4pswB:
undetectable		 1uujB-4pswB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		3 ARG A 115
TYR A  86
LYS A  90
 None
 1.04A 1uujB-4rgqA:
1.6		 1uujB-4rgqA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		3 ARG A2539
TYR A2573
LYS A2572
 None
 1.02A 1uujB-4rlvA:
undetectable		 1uujB-4rlvA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Human
coronavirus
229E) 		PF06471
(NSP11) 		3 ARG A 125
TYR A  81
LYS A  82
 None
 0.97A 1uujB-4s1tA:
undetectable		 1uujB-4s1tA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		3 ARG A 154
TYR A 123
LYS A 127
 None
 0.66A 1uujB-4ur8A:
undetectable		 1uujB-4ur8A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		3 ARG A 272
TYR A 268
LYS A 261
 U  D  20 ( 4.0A)
None
None
 0.56A 1uujB-4ycoA:
undetectable		 1uujB-4ycoA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywl CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ARG A 228
TYR A 153
LYS A 151
 None
 1.06A 1uujB-4ywlA:
undetectable		 1uujB-4ywlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		3 ARG A 280
TYR A 256
LYS A 260
 None
 0.89A 1uujB-4ztcA:
0.1		 1uujB-4ztcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		3 ARG A 287
TYR A 277
LYS A 275
 None
 1.04A 1uujB-5cvoA:
undetectable		 1uujB-5cvoA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		3 ARG A 548
TYR A 435
LYS A 439
 None
 1.08A 1uujB-5e3cA:
1.6		 1uujB-5e3cA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 ARG A  88
TYR A 166
LYS A 170
 None
 0.98A 1uujB-5h8wA:
undetectable		 1uujB-5h8wA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifw TETHER CONTAINING
UBX DOMAIN FOR GLUT4

(Homo sapiens) 		PF00789
(UBX) 		3 ARG A 492
TYR A 493
LYS A 390
 None
 0.93A 1uujB-5ifwA:
undetectable		 1uujB-5ifwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		3 ARG A 416
TYR A 535
LYS A 515
 None
 1.02A 1uujB-5ijlA:
undetectable		 1uujB-5ijlA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 ARG A 256
TYR A 216
LYS A 206
 None
 1.04A 1uujB-5j1lA:
undetectable		 1uujB-5j1lA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 ARG A 453
TYR A 477
LYS A 216
 None
 1.07A 1uujB-5jbgA:
1.4		 1uujB-5jbgA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		3 ARG A 176
TYR A 228
LYS A 179
 None
 0.97A 1uujB-5kssA:
undetectable		 1uujB-5kssA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00421
(PSII)
PF01716
(MSP) 		3 ARG C 370
TYR O 102
LYS O 106
 None
 0.81A 1uujB-5mdxC:
undetectable		 1uujB-5mdxC:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B

(Mus musculus) 		no annotation 3 ARG A 779
TYR A 728
LYS A 732
 None
 0.87A 1uujB-5ml0A:
undetectable		 1uujB-5ml0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		3 ARG B 271
TYR B 270
LYS B 336
 None
 0.73A 1uujB-5njfB:
undetectable		 1uujB-5njfB:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugw TELOMERASE REVERSE
TRANSCRIPTASE

(Homo sapiens) 		no annotation 3 ARG A 972
TYR A1010
LYS A1081
 None
 0.87A 1uujB-5ugwA:
undetectable		 1uujB-5ugwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 3 ARG A 247
TYR A 244
LYS A 183
 None
 0.93A 1uujB-5xepA:
undetectable		 1uujB-5xepA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y33 ALGINATE LYASE

(Flavobacterium
sp. UMI-01) 		no annotation 3 ARG A 195
TYR A 254
LYS A 252
 None
 1.04A 1uujB-5y33A:
undetectable		 1uujB-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czs -

(-) 		no annotation 3 ARG A  54
TYR A  46
LYS A  44
 None
None
SO4  A 409 ( 4.0A)
 1.07A 1uujB-6czsA:
undetectable		 1uujB-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG i 305
TYR i 260
LYS i 264
 C  21216 ( 3.7A)
None
C  21216 ( 4.8A)
 0.96A 1uujB-6faii:
undetectable		 1uujB-6faii:
undetectable