SIMILAR PATTERNS OF AMINO ACIDS FOR 1UTD_Q_TRPQ81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 GLY A 431
ALA A 378
THR A 370
THR A 394
SER A 374
 None
 1.36A 1utdQ-1fc9A:
undetectable
1utdR-1fc9A:
undetectable		 1utdQ-1fc9A:
12.11
1utdR-1fc9A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3q SEDLIN

(Mus musculus) 		PF04628
(Sedlin_N) 		5 GLY A  11
HIS A  12
THR A  77
HIS A  80
ILE A   9
 None
 0.98A 1utdQ-1h3qA:
0.1
1utdR-1h3qA:
0.1		 1utdQ-1h3qA:
19.12
1utdR-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iom CITRATE SYNTHASE

(Thermus
thermophilus) 		PF00285
(Citrate_synt) 		5 HIS A 153
ALA A 182
THR A  47
ILE A 179
SER A 339
 None
 1.33A 1utdQ-1iomA:
undetectable
1utdR-1iomA:
undetectable		 1utdQ-1iomA:
11.08
1utdR-1iomA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.10A 1utdQ-1l5jA:
undetectable
1utdR-1l5jA:
undetectable		 1utdQ-1l5jA:
7.07
1utdR-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 THR A 688
HIS A 652
THR A 655
ILE A 679
THR A 591
 None
 1.33A 1utdQ-1lzxA:
undetectable
1utdR-1lzxA:
undetectable		 1utdQ-1lzxA:
10.02
1utdR-1lzxA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 THR A 457
HIS A 421
THR A 424
ILE A 448
THR A 360
 None
 1.33A 1utdQ-1m9qA:
undetectable
1utdR-1m9qA:
0.0		 1utdQ-1m9qA:
9.88
1utdR-1m9qA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 GLY B 156
ALA B 151
THR B 139
HIS B 103
THR B 137
 None
 1.23A 1utdQ-1mioB:
undetectable
1utdR-1mioB:
undetectable		 1utdQ-1mioB:
9.76
1utdR-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 GLY A 116
ALA A 262
THR A 123
ILE A 102
SER A 121
 MG  A 401 (-3.8A)
None
None
None
None
 1.29A 1utdQ-1n0wA:
undetectable
1utdR-1n0wA:
undetectable		 1utdQ-1n0wA:
14.40
1utdR-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus;
Bean pod mottle
virus) 		PF02248
(Como_SCP)
PF02247
(Como_LCP) 		5 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
 None
 1.08A 1utdQ-1pgw2:
undetectable
1utdR-1pgw2:
0.9		 1utdQ-1pgw2:
11.68
1utdR-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
 None
 1.34A 1utdQ-1ps9A:
undetectable
1utdR-1ps9A:
undetectable		 1utdQ-1ps9A:
8.10
1utdR-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 188
ALA A 196
THR A  49
THR A 183
THR A  40
 None
 1.16A 1utdQ-1v9cA:
undetectable
1utdR-1v9cA:
undetectable		 1utdQ-1v9cA:
19.25
1utdR-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 GLY A  15
ALA A  23
THR A 252
ILE A  13
SER A 495
 FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
None
 1.04A 1utdQ-1yy5A:
undetectable
1utdR-1yy5A:
undetectable		 1utdQ-1yy5A:
9.73
1utdR-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 GLY A 238
HIS A 237
THR A 172
ILE A 183
THR A 271
 None
None
FLC  A 501 (-4.7A)
None
ZN  A 500 ( 4.4A)
 1.10A 1utdQ-1zb7A:
undetectable
1utdR-1zb7A:
undetectable		 1utdQ-1zb7A:
9.28
1utdR-1zb7A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 GLY A 227
THR A 186
HIS A 185
THR A 184
ILE A 226
 None
 1.20A 1utdQ-1zwxA:
undetectable
1utdR-1zwxA:
undetectable		 1utdQ-1zwxA:
13.62
1utdR-1zwxA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 127
HIS A 134
THR A 136
ILE A 125
SER A  59
 None
 1.16A 1utdQ-2be7A:
undetectable
1utdR-2be7A:
undetectable		 1utdQ-2be7A:
13.19
1utdR-2be7A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		5 HIS A 175
ALA A 159
THR A  98
ILE A  96
THR A 183
 None
 1.26A 1utdQ-2d6fA:
undetectable
1utdR-2d6fA:
undetectable		 1utdQ-2d6fA:
12.81
1utdR-2d6fA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.94A 1utdQ-2dw4A:
undetectable
1utdR-2dw4A:
undetectable		 1utdQ-2dw4A:
8.15
1utdR-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 HIS A 103
HIS A  99
THR A 100
ILE A 190
THR A 172
 ZN  A 300 (-4.4A)
ZN  A 300 (-3.9A)
None
None
None
 1.23A 1utdQ-2e1bA:
undetectable
1utdR-2e1bA:
undetectable		 1utdQ-2e1bA:
18.18
1utdR-2e1bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		5 GLY A 284
HIS A 240
ALA A 308
HIS A 291
ILE A 286
 None
CU  A 517 (-3.1A)
None
CU  A 517 ( 3.1A)
None
 1.34A 1utdQ-2eijA:
undetectable
1utdR-2eijA:
undetectable		 1utdQ-2eijA:
9.53
1utdR-2eijA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT

(Escherichia
coli) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		5 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.21A 1utdQ-2f1fA:
undetectable
1utdR-2f1fA:
undetectable		 1utdQ-2f1fA:
20.48
1utdR-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 GLY B 677
ALA B 688
THR B 417
HIS B 682
ILE B 676
 None
None
None
NI  B 901 (-2.8A)
None
 1.07A 1utdQ-2fffB:
undetectable
1utdR-2fffB:
undetectable		 1utdQ-2fffB:
11.03
1utdR-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 GLY A 229
HIS A 230
HIS A 227
ILE A 111
THR A 265
 None
None
ZN  A   1 (-3.3A)
None
None
 1.24A 1utdQ-2nz9A:
undetectable
1utdR-2nz9A:
undetectable		 1utdQ-2nz9A:
4.73
1utdR-2nz9A:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 HIS A 230
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 1.00A 1utdQ-2o2cA:
undetectable
1utdR-2o2cA:
undetectable		 1utdQ-2o2cA:
9.57
1utdR-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		5 GLY A  55
HIS A 157
THR A  11
THR A 154
ILE A  57
 None
 1.36A 1utdQ-2ok8A:
undetectable
1utdR-2ok8A:
undetectable		 1utdQ-2ok8A:
12.05
1utdR-2ok8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 HIS A  32
THR A 203
HIS A 202
THR A 101
SER A 178
 None
None
None
GG9  A 501 (-3.3A)
GG9  A 501 ( 4.8A)
 1.31A 1utdQ-2pqdA:
undetectable
1utdR-2pqdA:
undetectable		 1utdQ-2pqdA:
10.20
1utdR-2pqdA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
GSP  A 401 (-3.6A)
None
 1.33A 1utdQ-2q1yA:
undetectable
1utdR-2q1yA:
undetectable		 1utdQ-2q1yA:
12.94
1utdR-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 GLY A  72
HIS A  71
ALA A  19
THR A  98
ILE A  66
 None
 1.02A 1utdQ-2qcvA:
undetectable
1utdR-2qcvA:
undetectable		 1utdQ-2qcvA:
15.70
1utdR-2qcvA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ALA A 111
THR A  61
HIS A  62
THR A 124
ILE A 153
 None
None
ZN  A 501 (-3.3A)
None
None
 1.20A 1utdQ-2qt3A:
undetectable
1utdR-2qt3A:
undetectable		 1utdQ-2qt3A:
14.29
1utdR-2qt3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		5 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 1utdQ-2x7vA:
undetectable
1utdR-2x7vA:
undetectable		 1utdQ-2x7vA:
13.50
1utdR-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 435
ALA A 407
THR A 442
THR A 439
SER A 402
 ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
None
 1.24A 1utdQ-2xzlA:
undetectable
1utdR-2xzlA:
undetectable		 1utdQ-2xzlA:
7.24
1utdR-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.31A 1utdQ-2zy2A:
undetectable
1utdR-2zy2A:
undetectable		 1utdQ-2zy2A:
8.61
1utdR-2zy2A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.36A 1utdQ-3a1nA:
undetectable
1utdR-3a1nA:
undetectable		 1utdQ-3a1nA:
13.02
1utdR-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 GLY A 181
HIS A 180
HIS A 183
ALA A 188
ILE A 145
 None
 1.35A 1utdQ-3afgA:
2.9
1utdR-3afgA:
3.0		 1utdQ-3afgA:
11.86
1utdR-3afgA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 166
ALA A 194
THR A 284
ILE A 187
THR A 295
 None
 1.06A 1utdQ-3b9gA:
undetectable
1utdR-3b9gA:
undetectable		 1utdQ-3b9gA:
13.11
1utdR-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ALA A 187
THR A 426
THR A 414
ILE A 184
SER A 191
 None
 0.97A 1utdQ-3cb5A:
undetectable
1utdR-3cb5A:
undetectable		 1utdQ-3cb5A:
9.95
1utdR-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dse BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 GLY A 229
HIS A 230
HIS A 227
ILE A 111
THR A 265
 None
None
ZN  A 501 (-3.3A)
None
None
 1.17A 1utdQ-3dseA:
undetectable
1utdR-3dseA:
undetectable		 1utdQ-3dseA:
10.71
1utdR-3dseA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 HIS A 607
ALA A 677
THR A 610
HIS A 611
ILE A 471
 ZN  A 771 ( 3.4A)
None
None
ZN  A 771 ( 3.3A)
None
 1.34A 1utdQ-3dwbA:
undetectable
1utdR-3dwbA:
undetectable		 1utdQ-3dwbA:
7.51
1utdR-3dwbA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A 111
ALA A 117
THR A 138
ILE A 110
SER A 115
 None
 1.27A 1utdQ-3e7dA:
undetectable
1utdR-3e7dA:
undetectable		 1utdQ-3e7dA:
17.31
1utdR-3e7dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 GLY A 208
ALA A 212
THR A 239
HIS A 204
SER A 214
 None
 1.32A 1utdQ-3eegA:
undetectable
1utdR-3eegA:
undetectable		 1utdQ-3eegA:
17.23
1utdR-3eegA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 GLY A  86
ALA A  94
THR A 246
ILE A  84
SER A 322
 AHZ  A 500 (-3.0A)
None
None
None
None
 1.16A 1utdQ-3jskA:
undetectable
1utdR-3jskA:
undetectable		 1utdQ-3jskA:
13.37
1utdR-3jskA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		5 GLY A 192
THR A 151
HIS A 150
THR A 149
ILE A 191
 None
 1.16A 1utdQ-3k55A:
undetectable
1utdR-3k55A:
undetectable		 1utdQ-3k55A:
13.73
1utdR-3k55A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		5 GLY A 282
ALA A 221
HIS A 277
ILE A 307
THR A 358
 None
 1.31A 1utdQ-3k5hA:
undetectable
1utdR-3k5hA:
undetectable		 1utdQ-3k5hA:
11.53
1utdR-3k5hA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		5 HIS A 212
ALA A 220
HIS A   7
THR A 230
ILE A 217
 None
None
ACT  A 252 ( 3.6A)
None
None
 1.34A 1utdQ-3ks5A:
undetectable
1utdR-3ks5A:
undetectable		 1utdQ-3ks5A:
14.74
1utdR-3ks5A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		5 GLY A  58
ALA A 109
HIS A  85
ILE A 128
SER A 107
 None
 1.18A 1utdQ-3ktoA:
undetectable
1utdR-3ktoA:
undetectable		 1utdQ-3ktoA:
18.94
1utdR-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1utdQ-3l8kA:
undetectable
1utdR-3l8kA:
undetectable		 1utdQ-3l8kA:
11.76
1utdR-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 GLY A 237
HIS A 234
ALA A 173
THR A 416
THR A 194
 None
 1.17A 1utdQ-3q8nA:
undetectable
1utdR-3q8nA:
undetectable		 1utdQ-3q8nA:
9.98
1utdR-3q8nA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqy RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
PROTEIN FUSION

(Ophiostoma
novo-ulmi) 		PF00961
(LAGLIDADG_1) 		5 GLY A 127
HIS A 122
ILE A 125
THR A  41
SER A  35
 None
 1.20A 1utdQ-3qqyA:
undetectable
1utdR-3qqyA:
undetectable		 1utdQ-3qqyA:
14.86
1utdR-3qqyA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.20A 1utdQ-3rwbA:
undetectable
1utdR-3rwbA:
undetectable		 1utdQ-3rwbA:
16.06
1utdR-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 HIS A 235
ALA A 212
HIS A 236
ILE A 208
SER A 214
 ZN  A 461 (-3.4A)
None
None
None
None
 1.26A 1utdQ-3tqoA:
undetectable
1utdR-3tqoA:
undetectable		 1utdQ-3tqoA:
10.75
1utdR-3tqoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 124
HIS A 130
THR A 132
ILE A 122
SER A  58
 None
 1.21A 1utdQ-3txxA:
undetectable
1utdR-3txxA:
undetectable		 1utdQ-3txxA:
11.21
1utdR-3txxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 325
ALA A 212
THR A 320
ILE A 326
SER A 215
 None
 1.23A 1utdQ-3u0oA:
undetectable
1utdR-3u0oA:
undetectable		 1utdQ-3u0oA:
13.79
1utdR-3u0oA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLY A 133
HIS A 151
THR A 152
ILE A 134
SER A 148
 None
 1.15A 1utdQ-3wpeA:
undetectable
1utdR-3wpeA:
undetectable		 1utdQ-3wpeA:
7.17
1utdR-3wpeA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 GLY A 209
HIS A 388
THR A 387
ILE A 208
THR A 213
 None
FMN  A 500 (-4.6A)
None
None
FMN  A 500 ( 4.6A)
 1.18A 1utdQ-3x0yA:
undetectable
1utdR-3x0yA:
undetectable		 1utdQ-3x0yA:
11.36
1utdR-3x0yA:
11.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.35A 1utdQ-3zteA:
14.5
1utdR-3zteA:
14.9		 1utdQ-3zteA:
78.21
1utdR-3zteA:
78.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 GLY A 229
HIS A 230
HIS A 227
ILE A 111
THR A 265
 None
None
ZN  A1916 (-3.3A)
None
None
 1.17A 1utdQ-3zusA:
undetectable
1utdR-3zusA:
undetectable		 1utdQ-3zusA:
6.44
1utdR-3zusA:
6.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.41A 1utdQ-3zzlA:
12.8
1utdR-3zzlA:
12.9		 1utdQ-3zzlA:
71.43
1utdR-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		5 HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.78A 1utdQ-3zzlA:
12.8
1utdR-3zzlA:
12.9		 1utdQ-3zzlA:
71.43
1utdR-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.27A 1utdQ-3zzqA:
13.3
1utdR-3zzqA:
13.5		 1utdQ-3zzqA:
80.00
1utdR-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
 0.86A 1utdQ-3zzqA:
13.3
1utdR-3zzqA:
13.5		 1utdQ-3zzqA:
80.00
1utdR-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.25A 1utdQ-3zzsA:
13.3
1utdR-3zzsA:
13.4		 1utdQ-3zzsA:
100.00
1utdR-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 None
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
 0.78A 1utdQ-3zzsA:
13.3
1utdR-3zzsA:
13.4		 1utdQ-3zzsA:
100.00
1utdR-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ALA A 320
THR A 377
HIS A 249
THR A 250
ILE A 315
 None
None
HEM  A1715 (-3.9A)
None
None
 1.31A 1utdQ-4aj9A:
undetectable
1utdR-4aj9A:
undetectable		 1utdQ-4aj9A:
8.76
1utdR-4aj9A:
8.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 1utdQ-4b27A:
12.9
1utdR-4b27A:
13.0		 1utdQ-4b27A:
76.32
1utdR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
 0.79A 1utdQ-4b27A:
12.9
1utdR-4b27A:
13.0		 1utdQ-4b27A:
76.32
1utdR-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 ALA A 500
THR A 572
THR A 545
ILE A 547
SER A 504
 None
 1.17A 1utdQ-4bx9A:
undetectable
1utdR-4bx9A:
undetectable		 1utdQ-4bx9A:
7.91
1utdR-4bx9A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 SO4  A 607 (-3.4A)
None
None
SO4  A 607 (-4.3A)
None
 1.23A 1utdQ-4e6eA:
undetectable
1utdR-4e6eA:
undetectable		 1utdQ-4e6eA:
12.06
1utdR-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ALA A  69
HIS A  54
THR A  55
ILE A  57
THR A  76
 None
 1.20A 1utdQ-4fc7A:
undetectable
1utdR-4fc7A:
undetectable		 1utdQ-4fc7A:
16.60
1utdR-4fc7A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 GLY A 203
ALA A 233
HIS A 207
ILE A 245
SER A 252
 None
 1.13A 1utdQ-4fqdA:
undetectable
1utdR-4fqdA:
undetectable		 1utdQ-4fqdA:
9.50
1utdR-4fqdA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 GLY A 389
ALA A 397
THR A 626
ILE A 387
SER A 811
 FAD  A 901 (-3.3A)
None
None
None
None
 1.00A 1utdQ-4hsuA:
undetectable
1utdR-4hsuA:
undetectable		 1utdQ-4hsuA:
7.64
1utdR-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 GLY B 191
THR B 340
THR B 339
ILE B 194
THR B 169
 None
 1.06A 1utdQ-4i6mB:
undetectable
1utdR-4i6mB:
undetectable		 1utdQ-4i6mB:
11.93
1utdR-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre IMMUNOGLOBULIN
GAMMA-2A, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  33
ALA B  79
THR B  53
ILE B  51
SER B  77
 None
 1.09A 1utdQ-4jreB:
undetectable
1utdR-4jreB:
undetectable		 1utdQ-4jreB:
15.89
1utdR-4jreB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 HIS A  66
ALA A 103
THR A  44
THR A  40
ILE A  34
 None
 1.19A 1utdQ-4kpoA:
undetectable
1utdR-4kpoA:
undetectable		 1utdQ-4kpoA:
15.07
1utdR-4kpoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		5 GLY A 213
ALA A 217
THR A 244
HIS A 209
SER A 219
 None
None
None
ZN  A 401 ( 3.4A)
None
 1.14A 1utdQ-4ov4A:
undetectable
1utdR-4ov4A:
undetectable		 1utdQ-4ov4A:
11.11
1utdR-4ov4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 GLY A  84
ALA A  71
HIS A 119
THR A 115
THR A  87
 None
 1.35A 1utdQ-4q0gA:
undetectable
1utdR-4q0gA:
undetectable		 1utdQ-4q0gA:
9.33
1utdR-4q0gA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		5 GLY A 164
ALA A 144
THR A 115
THR A 169
SER A 142
 None
 1.16A 1utdQ-4xgnA:
undetectable
1utdR-4xgnA:
undetectable		 1utdQ-4xgnA:
13.85
1utdR-4xgnA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 GLY A 287
HIS A 242
THR A  11
HIS A 290
THR A 132
 None
 1.25A 1utdQ-4xiaA:
undetectable
1utdR-4xiaA:
undetectable		 1utdQ-4xiaA:
12.47
1utdR-4xiaA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 5 GLY A 184
HIS A  84
ALA A 304
THR A 187
SER A 126
 None
 1.29A 1utdQ-5ah1A:
undetectable
1utdR-5ah1A:
undetectable		 1utdQ-5ah1A:
10.95
1utdR-5ah1A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 GLY A 232
ALA A 209
THR A 122
THR A 231
ILE A 236
 None
 1.30A 1utdQ-5dmhA:
undetectable
1utdR-5dmhA:
undetectable		 1utdQ-5dmhA:
9.45
1utdR-5dmhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 245
ALA A  85
THR A 244
ILE A 240
SER A  87
 None
None
None
None
PLP  A 501 (-3.7A)
 1.32A 1utdQ-5dx5A:
undetectable
1utdR-5dx5A:
undetectable		 1utdQ-5dx5A:
11.50
1utdR-5dx5A:
11.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 None
 0.28A 1utdQ-5eexA:
15.0
1utdR-5eexA:
15.2		 1utdQ-5eexA:
100.00
1utdR-5eexA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 None
 0.78A 1utdQ-5eexA:
15.0
1utdR-5eexA:
15.2		 1utdQ-5eexA:
100.00
1utdR-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho1 MAGNETOSOME PROTEIN
MAMB

(Magnetospira
sp. QH-2) 		PF16916
(ZT_dimer) 		5 GLY A 237
HIS A 245
ALA A 219
HIS A 283
ILE A 235
 None
ZN  A 301 (-3.4A)
None
ZN  A 301 (-3.3A)
None
 1.33A 1utdQ-5ho1A:
undetectable
1utdR-5ho1A:
undetectable		 1utdQ-5ho1A:
20.37
1utdR-5ho1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		5 GLY B1459
HIS B1548
THR B1539
HIS B1546
ILE B1458
 None
 1.15A 1utdQ-5hzkB:
undetectable
1utdR-5hzkB:
undetectable		 1utdQ-5hzkB:
9.11
1utdR-5hzkB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A 901 (-3.3A)
None
None
None
None
 0.97A 1utdQ-5l3dA:
undetectable
1utdR-5l3dA:
undetectable		 1utdQ-5l3dA:
6.27
1utdR-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgc ARCE4A

(Arthrobacter
sp. AW19M34-1) 		PF01522
(Polysacc_deac_1) 		5 GLY A  80
THR A 199
HIS A  77
THR A  54
ILE A 118
 None
 1.11A 1utdQ-5lgcA:
undetectable
1utdR-5lgcA:
undetectable		 1utdQ-5lgcA:
17.89
1utdR-5lgcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A2074
HIS A2081
THR A2083
ILE A2072
SER A2008
 None
 1.31A 1utdQ-5nnnA:
undetectable
1utdR-5nnnA:
undetectable		 1utdQ-5nnnA:
15.08
1utdR-5nnnA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 GLY A 172
ALA A 180
THR A 190
ILE A 175
SER A 186
 None
 1.16A 1utdQ-5o1mA:
undetectable
1utdR-5o1mA:
undetectable		 1utdQ-5o1mA:
12.64
1utdR-5o1mA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile) 		no annotation 5 GLY C  51
HIS C  89
ALA C  71
THR C  90
ILE C  52
 None
 1.36A 1utdQ-5ol2C:
undetectable
1utdR-5ol2C:
undetectable		 1utdQ-5ol2C:
11.38
1utdR-5ol2C:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		5 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
 EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
 1.36A 1utdQ-5u2pA:
undetectable
1utdR-5u2pA:
undetectable		 1utdQ-5u2pA:
11.24
1utdR-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 538
HIS A 542
ALA A 481
HIS A 755
THR A 541
 None
 1.13A 1utdQ-5ux5A:
undetectable
1utdR-5ux5A:
undetectable		 1utdQ-5ux5A:
5.76
1utdR-5ux5A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  99
HIS A 253
ALA A 104
ILE A 100
SER A 106
 None
 1.35A 1utdQ-5xd7A:
undetectable
1utdR-5xd7A:
undetectable		 1utdQ-5xd7A:
11.52
1utdR-5xd7A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		5 GLY A 282
HIS A 243
THR A  12
HIS A 285
THR A 133
 None
 1.28A 1utdQ-5y4jA:
undetectable
1utdR-5y4jA:
undetectable		 1utdQ-5y4jA:
16.30
1utdR-5y4jA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 GLY C  65
ALA C 278
HIS C 271
ILE C 138
SER C 276
 None
 1.35A 1utdQ-5y6qC:
undetectable
1utdR-5y6qC:
undetectable		 1utdQ-5y6qC:
undetectable
1utdR-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLY A 147
ALA A 622
HIS A 626
THR A 627
ILE A 148
 SO4  A 706 ( 4.4A)
None
SO4  A 706 (-3.9A)
None
None
 1.22A 1utdQ-5y6rA:
undetectable
1utdR-5y6rA:
undetectable		 1utdQ-5y6rA:
undetectable
1utdR-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLY A 147
ALA A 622
THR A 627
ILE A 148
SER A 618
 SO4  A 706 ( 4.4A)
None
None
None
None
 1.32A 1utdQ-5y6rA:
undetectable
1utdR-5y6rA:
undetectable		 1utdQ-5y6rA:
undetectable
1utdR-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 GLY A 126
ALA A 133
THR A 122
THR A 124
ILE A 159
 PO4  A 504 (-4.5A)
None
None
PO4  A 504 (-3.6A)
None
 1.07A 1utdQ-5ygrA:
undetectable
1utdR-5ygrA:
undetectable		 1utdQ-5ygrA:
undetectable
1utdR-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 GLY A  34
ALA A  60
THR A  35
ILE A  71
SER A  58
 None
 1.21A 1utdQ-5z73A:
undetectable
1utdR-5z73A:
undetectable		 1utdQ-5z73A:
undetectable
1utdR-5z73A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 GLY A 134
HIS A 152
THR A 153
ILE A 135
SER A 149
 None
 1.10A 1utdQ-5zlnA:
undetectable
1utdR-5zlnA:
undetectable		 1utdQ-5zlnA:
undetectable
1utdR-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 GLY A 803
HIS A 801
ALA A 745
THR A1328
ILE A 806
 None
None
None
ATP  A1602 (-3.9A)
None
 1.27A 1utdQ-6bhuA:
undetectable
1utdR-6bhuA:
undetectable		 1utdQ-6bhuA:
undetectable
1utdR-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY

(Thermobifida
fusca) 		no annotation 5 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.27A 1utdQ-6c66G:
undetectable
1utdR-6c66G:
undetectable		 1utdQ-6c66G:
undetectable
1utdR-6c66G:
undetectable