SIMILAR PATTERNS OF AMINO ACIDS FOR 1UTD_O_TRPO81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 ALA A 585
THR A 596
ILE A 639
GLY A 593
ALA A 588
 None
 0.96A 1utdO-1c30A:
0.0
1utdP-1c30A:
0.7		 1utdO-1c30A:
5.50
1utdP-1c30A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		5 GLY A 120
THR A 271
ILE A 118
GLY A 227
ALA A 232
 None
 0.95A 1utdO-1hi9A:
undetectable
1utdP-1hi9A:
0.0		 1utdO-1hi9A:
15.08
1utdP-1hi9A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 723
ALA A 740
ILE A 725
GLY A 225
ALA A 741
 None
None
None
6FA  A 801 (-3.3A)
None
 1.02A 1utdO-1naaA:
undetectable
1utdP-1naaA:
undetectable		 1utdO-1naaA:
7.39
1utdP-1naaA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		5 GLY A 151
ALA A 177
ILE A 104
SER A  95
ALA A  94
 None
 1.04A 1utdO-1odiA:
0.0
1utdP-1odiA:
undetectable		 1utdO-1odiA:
14.71
1utdP-1odiA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 ALA A 204
THR A 192
ILE A 208
GLY A 157
ALA A 198
 None
 0.95A 1utdO-1oy1A:
undetectable
1utdP-1oy1A:
undetectable		 1utdO-1oy1A:
16.00
1utdP-1oy1A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 GLY A  69
ALA A  83
ILE A  85
GLY A  46
ALA A  76
 None
 0.99A 1utdO-1pweA:
undetectable
1utdP-1pweA:
undetectable		 1utdO-1pweA:
13.98
1utdP-1pweA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 GLY B 209
HIS B 219
THR B 223
ILE B 248
GLY B 262
 None
MGM  B 379 (-3.7A)
None
None
None
 0.99A 1utdO-1tnuB:
undetectable
1utdP-1tnuB:
undetectable		 1utdO-1tnuB:
12.68
1utdP-1tnuB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		5 GLY A 296
ALA A 197
HIS A 194
ILE A 291
GLY A 193
 None
 0.75A 1utdO-1wd3A:
0.2
1utdP-1wd3A:
0.2		 1utdO-1wd3A:
9.13
1utdP-1wd3A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 GLY A  15
ALA A  23
THR A 252
ILE A  13
SER A 495
 FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
None
 1.01A 1utdO-1yy5A:
undetectable
1utdP-1yy5A:
undetectable		 1utdO-1yy5A:
9.73
1utdP-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 HIS A  21
ALA A 141
ILE A  18
GLY A 119
THR A 100
 None
 1.02A 1utdO-2b42A:
undetectable
1utdP-2b42A:
undetectable		 1utdO-2b42A:
10.50
1utdP-2b42A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		5 GLY A 537
THR A 659
HIS A 534
THR A 510
GLY A 533
 None
 1.03A 1utdO-2c79A:
undetectable
1utdP-2c79A:
undetectable		 1utdO-2c79A:
14.85
1utdP-2c79A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 GLY A 140
HIS A 139
HIS A  99
GLY A 239
ALA A 123
 None
None
MN  A 301 ( 3.2A)
None
MN  A 302 ( 4.5A)
 0.97A 1utdO-2cevA:
undetectable
1utdP-2cevA:
undetectable		 1utdO-2cevA:
14.81
1utdP-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		5 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.93A 1utdO-2detA:
undetectable
1utdP-2detA:
undetectable		 1utdO-2detA:
11.89
1utdP-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.93A 1utdO-2dw4A:
undetectable
1utdP-2dw4A:
undetectable		 1utdO-2dw4A:
8.15
1utdP-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 HIS A 190
THR A 124
THR A 121
GLY A 187
THR A 189
 DGL  A 278 ( 4.5A)
None
DGL  A 278 (-3.6A)
None
DGL  A 278 (-3.0A)
 1.03A 1utdO-2dwuA:
undetectable
1utdP-2dwuA:
undetectable		 1utdO-2dwuA:
16.50
1utdP-2dwuA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 GLY A 309
ALA A 325
GLY A 477
SER A 323
ALA A 324
 None
 0.91A 1utdO-2ehqA:
undetectable
1utdP-2ehqA:
undetectable		 1utdO-2ehqA:
9.82
1utdP-2ehqA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 1.01A 1utdO-2fknA:
undetectable
1utdP-2fknA:
undetectable		 1utdO-2fknA:
9.42
1utdP-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		5 GLY A 221
ALA A 205
ILE A 219
GLY A 138
ALA A 177
 None
 0.96A 1utdO-2fn9A:
undetectable
1utdP-2fn9A:
undetectable		 1utdO-2fn9A:
16.13
1utdP-2fn9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		5 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.96A 1utdO-2gtxA:
undetectable
1utdP-2gtxA:
undetectable		 1utdO-2gtxA:
18.59
1utdP-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 GLY A 168
HIS A  70
ALA A 178
ILE A 205
GLY A 191
 None
 0.98A 1utdO-2hj0A:
undetectable
1utdP-2hj0A:
undetectable		 1utdO-2hj0A:
10.04
1utdP-2hj0A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A  23
HIS A  59
ALA A  87
HIS A  58
ILE A  25
 None
 0.85A 1utdO-2i3aA:
undetectable
1utdP-2i3aA:
undetectable		 1utdO-2i3aA:
12.78
1utdP-2i3aA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.04A 1utdO-2o2cA:
undetectable
1utdP-2o2cA:
undetectable		 1utdO-2o2cA:
9.57
1utdP-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 271
ALA A 284
ILE A 275
GLY A 314
ALA A 285
 None
 0.99A 1utdO-2pgwA:
undetectable
1utdP-2pgwA:
undetectable		 1utdO-2pgwA:
9.87
1utdP-2pgwA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B
CYTOCHROME C1

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		5 GLY B 109
HIS B 111
ALA B 159
HIS A 291
GLY B   2
 None
 1.00A 1utdO-2qjpB:
undetectable
1utdP-2qjpB:
undetectable		 1utdO-2qjpB:
14.45
1utdP-2qjpB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
 None
 1.04A 1utdO-2v7gA:
undetectable
1utdP-2v7gA:
undetectable		 1utdO-2v7gA:
8.79
1utdP-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhe ACETYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep) 		5 HIS A 134
ILE A 129
GLY A 172
SER A 157
ALA A 139
 None
None
COA  A 300 (-3.5A)
None
None
 0.95A 1utdO-2vheA:
undetectable
1utdP-2vheA:
undetectable		 1utdO-2vheA:
15.62
1utdP-2vheA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY B 456
HIS B 314
ALA B 529
ILE B 457
GLY B 345
 None
None
HPA  B1780 ( 3.2A)
None
None
 0.91A 1utdO-2w55B:
undetectable
1utdP-2w55B:
undetectable		 1utdO-2w55B:
7.21
1utdP-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8u CHITIN DEACETYLASE

(Aspergillus
nidulans) 		PF01522
(Polysacc_deac_1) 		5 GLY A  95
THR A 223
HIS A  92
THR A  69
GLY A  91
 None
 0.99A 1utdO-2y8uA:
undetectable
1utdP-2y8uA:
undetectable		 1utdO-2y8uA:
14.60
1utdP-2y8uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 125
THR A 332
GLY A 289
SER A 300
ALA A 266
 None
 1.00A 1utdO-2zviA:
undetectable
1utdP-2zviA:
undetectable		 1utdO-2zviA:
10.43
1utdP-2zviA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 166
ALA A 194
THR A 284
ILE A 187
THR A 295
 None
 1.03A 1utdO-3b9gA:
undetectable
1utdP-3b9gA:
undetectable		 1utdO-3b9gA:
13.11
1utdP-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ALA A 187
THR A 426
THR A 414
ILE A 184
SER A 191
 None
 0.96A 1utdO-3cb5A:
undetectable
1utdP-3cb5A:
undetectable		 1utdO-3cb5A:
9.95
1utdP-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 1.00A 1utdO-3d8xA:
undetectable
1utdP-3d8xA:
undetectable		 1utdO-3d8xA:
13.12
1utdP-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		5 GLY A 251
ALA A 107
THR A 247
ILE A 204
GLY A 332
 None
 0.94A 1utdO-3fmqA:
undetectable
1utdP-3fmqA:
undetectable		 1utdO-3fmqA:
13.14
1utdP-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 THR A  92
ILE A  96
GLY A 117
SER A 269
ALA A 270
 PRP  A 401 (-4.2A)
None
PRP  A 401 (-3.2A)
None
None
 0.99A 1utdO-3gbrA:
undetectable
1utdP-3gbrA:
undetectable		 1utdO-3gbrA:
14.29
1utdP-3gbrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A 155
ALA A 146
ILE A 198
GLY A 103
ALA A 145
 None
 1.01A 1utdO-3gvcA:
undetectable
1utdP-3gvcA:
undetectable		 1utdO-3gvcA:
13.97
1utdP-3gvcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 GLY A 363
ALA A 352
THR A 378
ILE A 359
GLY A 396
 None
 0.93A 1utdO-3iwjA:
undetectable
1utdP-3iwjA:
undetectable		 1utdO-3iwjA:
10.54
1utdP-3iwjA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 GLY A 363
ALA A 352
THR A 378
ILE A 359
GLY A 396
 None
 0.91A 1utdO-3iwkA:
undetectable
1utdP-3iwkA:
undetectable		 1utdO-3iwkA:
10.34
1utdP-3iwkA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3w 50S RIBOSOMAL
PROTEIN L15

(Bacillus
subtilis) 		PF00828
(Ribosomal_L27A) 		5 ALA L 132
THR L 142
ILE L 111
GLY L 140
ALA L 135
 None
 1.02A 1utdO-3j3wL:
undetectable
1utdP-3j3wL:
undetectable		 1utdO-3j3wL:
19.40
1utdP-3j3wL:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9x D-XYLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 GLY A 220
ALA A 203
ILE A 218
GLY A 131
ALA A 174
 None
 1.02A 1utdO-3m9xA:
undetectable
1utdP-3m9xA:
undetectable		 1utdO-3m9xA:
12.87
1utdP-3m9xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		6 GLY A 229
ALA A 224
THR A 177
GLY A 239
SER A 222
ALA A 223
 None
 1.45A 1utdO-3qomA:
undetectable
1utdP-3qomA:
undetectable		 1utdO-3qomA:
11.23
1utdP-3qomA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 120
ALA A 111
HIS A 108
GLY A  94
ALA A  97
 None
None
ZN  A 186 (-3.3A)
None
None
 0.92A 1utdO-3s6lA:
undetectable
1utdP-3s6lA:
undetectable		 1utdO-3s6lA:
18.71
1utdP-3s6lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
 None
None
RMO  C1317 ( 3.6A)
None
None
 0.95A 1utdO-3sr6C:
undetectable
1utdP-3sr6C:
undetectable		 1utdO-3sr6C:
7.93
1utdP-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ALA A 124
THR A  14
GLY A  94
SER A 120
ALA A 121
 None
None
NAP  A 601 (-3.2A)
None
None
 1.00A 1utdO-3toxA:
undetectable
1utdP-3toxA:
undetectable		 1utdO-3toxA:
15.71
1utdP-3toxA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ALA A 124
THR A  14
ILE A  12
GLY A  94
SER A 120
 None
None
None
NAP  A 601 (-3.2A)
None
 0.99A 1utdO-3toxA:
undetectable
1utdP-3toxA:
undetectable		 1utdO-3toxA:
15.71
1utdP-3toxA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trh PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CARBOXYLTRANSFERASE
SUBUNIT

(Coxiella
burnetii) 		PF00731
(AIRC) 		5 GLY A  86
THR A 115
ILE A  85
GLY A 118
ALA A  22
 None
 0.95A 1utdO-3trhA:
undetectable
1utdP-3trhA:
undetectable		 1utdO-3trhA:
18.79
1utdP-3trhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 GLY A 146
ALA A 257
ILE A 272
GLY A 170
ALA A 256
 None
 0.96A 1utdO-3vpzA:
undetectable
1utdP-3vpzA:
undetectable		 1utdO-3vpzA:
12.77
1utdP-3vpzA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
None
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.33A 1utdO-3zteA:
14.8
1utdP-3zteA:
14.2		 1utdO-3zteA:
78.21
1utdP-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.41A 1utdO-3zzlA:
12.9
1utdP-3zzlA:
13.1		 1utdO-3zzlA:
71.43
1utdP-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
TRP  A  81 ( 3.7A)
 1.00A 1utdO-3zzlA:
12.9
1utdP-3zzlA:
13.1		 1utdO-3zzlA:
71.43
1utdP-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.23A 1utdO-3zzqA:
13.4
1utdP-3zzqA:
13.6		 1utdO-3zzqA:
80.00
1utdP-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ALA A  46
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 3.7A)
 1.04A 1utdO-3zzqA:
13.4
1utdP-3zzqA:
13.6		 1utdO-3zzqA:
80.00
1utdP-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.24A 1utdO-3zzsA:
13.4
1utdP-3zzsA:
13.5		 1utdO-3zzsA:
100.00
1utdP-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 3.8A)
 1.09A 1utdO-3zzsA:
13.4
1utdP-3zzsA:
13.5		 1utdO-3zzsA:
100.00
1utdP-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 GLY A 360
ALA A 349
THR A 375
ILE A 356
GLY A 393
 None
 1.03A 1utdO-4a0mA:
undetectable
1utdP-4a0mA:
undetectable		 1utdO-4a0mA:
9.68
1utdP-4a0mA:
9.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 1utdO-4b27A:
13.0
1utdP-4b27A:
13.1		 1utdO-4b27A:
76.32
1utdP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.14A 1utdO-4b27A:
13.0
1utdP-4b27A:
13.1		 1utdO-4b27A:
76.32
1utdP-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.79A 1utdO-4cnkA:
undetectable
1utdP-4cnkA:
undetectable		 1utdO-4cnkA:
12.76
1utdP-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLY A 350
ALA A 338
THR A 363
ILE A 346
GLY A 381
 None
None
None
None
GOL  A 600 (-4.6A)
 0.98A 1utdO-4dalA:
undetectable
1utdP-4dalA:
undetectable		 1utdO-4dalA:
9.83
1utdP-4dalA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		5 GLY A 176
HIS A 175
HIS A 135
GLY A 255
ALA A 160
 UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
None
MN  A 401 ( 4.8A)
 0.99A 1utdO-4dz4A:
undetectable
1utdP-4dz4A:
undetectable		 1utdO-4dz4A:
11.56
1utdP-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo7 METHIONINE
AMINOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF00557
(Peptidase_M24) 		5 GLY A 106
HIS A 105
THR A 201
THR A 236
GLY A 171
 None
None
MN  A 301 ( 3.8A)
None
None
 0.99A 1utdO-4fo7A:
undetectable
1utdP-4fo7A:
undetectable		 1utdO-4fo7A:
15.30
1utdP-4fo7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuk METHIONINE
AMINOPEPTIDASE

(Trypanosoma
brucei) 		PF00557
(Peptidase_M24) 		5 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.02A 1utdO-4fukA:
undetectable
1utdP-4fukA:
undetectable		 1utdO-4fukA:
11.94
1utdP-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.97A 1utdO-4h27A:
undetectable
1utdP-4h27A:
undetectable		 1utdO-4h27A:
13.46
1utdP-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 GLY A 389
ALA A 397
THR A 626
ILE A 387
SER A 811
 FAD  A 901 (-3.3A)
None
None
None
None
 0.97A 1utdO-4hsuA:
undetectable
1utdP-4hsuA:
undetectable		 1utdO-4hsuA:
7.64
1utdP-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 ( 3.6A)
None
None
 1.00A 1utdO-4hxxA:
undetectable
1utdP-4hxxA:
undetectable		 1utdO-4hxxA:
11.80
1utdP-4hxxA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
 None
 0.97A 1utdO-4i8pA:
undetectable
1utdP-4i8pA:
undetectable		 1utdO-4i8pA:
9.81
1utdP-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 GLY A 364
ALA A 353
THR A 379
ILE A 360
GLY A 397
 None
 0.93A 1utdO-4i8qA:
undetectable
1utdP-4i8qA:
undetectable		 1utdO-4i8qA:
9.01
1utdP-4i8qA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 1.00A 1utdO-4iu6A:
undetectable
1utdP-4iu6A:
undetectable		 1utdO-4iu6A:
12.50
1utdP-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 ACETALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 GLY B 128
ALA B 189
THR B 132
GLY B 182
ALA B 175
 None
 1.02A 1utdO-4jn6B:
undetectable
1utdP-4jn6B:
undetectable		 1utdO-4jn6B:
14.09
1utdP-4jn6B:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		5 GLY A 191
ALA A 119
ILE A 190
GLY A 206
THR A 174
 None
 0.96A 1utdO-4m7gA:
undetectable
1utdP-4m7gA:
undetectable		 1utdO-4m7gA:
17.16
1utdP-4m7gA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Enterococcus
faecalis) 		PF04095
(NAPRTase) 		5 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.04A 1utdO-4mzyA:
undetectable
1utdP-4mzyA:
undetectable		 1utdO-4mzyA:
13.27
1utdP-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE

(Rhodotorula
mucilaginosa) 		PF13561
(adh_short_C2) 		5 ALA A  44
THR A  31
ILE A 111
GLY A  52
ALA A  47
 None
 0.86A 1utdO-4o0lA:
undetectable
1utdP-4o0lA:
undetectable		 1utdO-4o0lA:
15.27
1utdP-4o0lA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		5 GLY A 188
THR A 219
ILE A 189
GLY A   9
ALA A  12
 ASP  A 402 (-3.6A)
ASP  A 402 (-3.7A)
ASP  A 402 (-4.5A)
None
None
 1.04A 1utdO-4o48A:
0.4
1utdP-4o48A:
0.4		 1utdO-4o48A:
14.56
1utdP-4o48A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		5 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.93A 1utdO-4ookA:
undetectable
1utdP-4ookA:
undetectable		 1utdO-4ookA:
13.69
1utdP-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		6 GLY A  84
ALA A  71
HIS A 119
THR A 115
THR A  87
ALA A  68
 None
 1.37A 1utdO-4q0gA:
undetectable
1utdP-4q0gA:
undetectable		 1utdO-4q0gA:
9.33
1utdP-4q0gA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 GLY A 673
ILE A 670
GLY A 646
SER A 638
ALA A 662
 None
 0.98A 1utdO-4u7tA:
undetectable
1utdP-4u7tA:
undetectable		 1utdO-4u7tA:
9.89
1utdP-4u7tA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1521
THR A1364
GLY A1302
THR A1309
ALA A1335
 None
 0.88A 1utdO-4wxxA:
undetectable
1utdP-4wxxA:
undetectable		 1utdO-4wxxA:
4.84
1utdP-4wxxA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		5 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
 None
 1.03A 1utdO-4yhsA:
undetectable
1utdP-4yhsA:
undetectable		 1utdO-4yhsA:
14.02
1utdP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus musculus) 		PF01370
(Epimerase) 		5 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
 None
 1.02A 1utdO-4yraA:
undetectable
1utdP-4yraA:
undetectable		 1utdO-4yraA:
12.91
1utdP-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A1006
HIS A 884
ALA A1079
ILE A1007
GLY A 915
 None
None
URC  A3007 (-3.4A)
None
BCT  A3006 (-3.9A)
 0.94A 1utdO-4yswA:
undetectable
1utdP-4yswA:
undetectable		 1utdO-4yswA:
5.06
1utdP-4yswA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 GLY A 243
ALA A 226
ILE A 241
GLY A 154
ALA A 197
 None
 1.01A 1utdO-4ywhA:
undetectable
1utdP-4ywhA:
undetectable		 1utdO-4ywhA:
12.05
1utdP-4ywhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 ALA A  79
THR A  90
ILE A  58
GLY A  87
ALA A  82
 None
 0.91A 1utdO-5a5gA:
undetectable
1utdP-5a5gA:
undetectable		 1utdO-5a5gA:
10.41
1utdP-5a5gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		5 GLY A 115
ALA A 105
THR A 245
HIS A 248
ALA A 217
 None
 1.00A 1utdO-5b7nA:
undetectable
1utdP-5b7nA:
undetectable		 1utdO-5b7nA:
15.74
1utdP-5b7nA:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 None
 0.27A 1utdO-5eexA:
15.2
1utdP-5eexA:
15.3		 1utdO-5eexA:
100.00
1utdP-5eexA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 None
 1.11A 1utdO-5eexA:
15.2
1utdP-5eexA:
15.3		 1utdO-5eexA:
100.00
1utdP-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		5 GLY A 181
HIS A 184
THR A 151
ILE A 131
ALA A 189
 None
 1.01A 1utdO-5gggA:
undetectable
1utdP-5gggA:
undetectable		 1utdO-5gggA:
8.92
1utdP-5gggA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF15711
(ILEI) 		5 GLY A 181
HIS A 184
THR A 151
ILE A 131
ALA A 189
 None
 1.02A 1utdO-5ggkA:
undetectable
1utdP-5ggkA:
undetectable		 1utdO-5ggkA:
23.23
1utdP-5ggkA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 GLY B 378
ALA B 423
THR B 376
GLY B 343
THR B 327
 None
 1.01A 1utdO-5iklB:
undetectable
1utdP-5iklB:
undetectable		 1utdO-5iklB:
10.40
1utdP-5iklB:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 GLY A 232
ALA A 180
ILE A 236
GLY A  83
ALA A 181
 2OH  A 402 ( 3.8A)
2OH  A 402 ( 3.8A)
None
None
2OH  A 402 (-3.9A)
 0.85A 1utdO-5it1A:
undetectable
1utdP-5it1A:
undetectable		 1utdO-5it1A:
9.04
1utdP-5it1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A 901 (-3.3A)
None
None
None
None
 0.95A 1utdO-5l3dA:
undetectable
1utdP-5l3dA:
undetectable		 1utdO-5l3dA:
6.27
1utdP-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgc ARCE4A

(Arthrobacter
sp. AW19M34-1) 		PF01522
(Polysacc_deac_1) 		6 GLY A  80
THR A 199
HIS A  77
THR A  54
ILE A 118
GLY A  76
 None
 1.06A 1utdO-5lgcA:
undetectable
1utdP-5lgcA:
undetectable		 1utdO-5lgcA:
17.89
1utdP-5lgcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		5 ALA A 204
THR A 192
ILE A 208
GLY A 157
ALA A 198
 None
 1.01A 1utdO-5lirA:
undetectable
1utdP-5lirA:
undetectable		 1utdO-5lirA:
15.02
1utdP-5lirA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 5 GLY A 335
ALA A 379
THR A 361
GLY A 383
ALA A 380
 None
 0.97A 1utdO-5oj3A:
undetectable
1utdP-5oj3A:
undetectable		 1utdO-5oj3A:
undetectable
1utdP-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 GLY A 165
ALA A 103
THR A  21
ILE A 168
ALA A 104
 None
 0.96A 1utdO-5sy4A:
undetectable
1utdP-5sy4A:
undetectable		 1utdO-5sy4A:
17.62
1utdP-5sy4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 5 GLY A 225
THR A 278
ILE A 269
GLY A  22
THR A  20
 None
 0.90A 1utdO-5u6fA:
1.5
1utdP-5u6fA:
1.9		 1utdO-5u6fA:
undetectable
1utdP-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 765
ALA A 781
GLY A 933
SER A 779
ALA A 780
 None
 0.89A 1utdO-5ur2A:
undetectable
1utdP-5ur2A:
undetectable		 1utdO-5ur2A:
6.57
1utdP-5ur2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE

(Azospirillum
brasilense) 		PF00171
(Aldedh) 		5 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.92A 1utdO-5x5tA:
undetectable
1utdP-5x5tA:
undetectable		 1utdO-5x5tA:
10.44
1utdP-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z72 CCPC

(Bacillus
velezensis) 		no annotation 5 ILE A 218
GLY A 148
THR A 262
SER A 129
ALA A  98
 FLC  A 303 ( 4.5A)
None
None
FLC  A 303 ( 2.1A)
FLC  A 303 (-3.1A)
 0.95A 1utdO-5z72A:
undetectable
1utdP-5z72A:
undetectable		 1utdO-5z72A:
undetectable
1utdP-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 HIS B 402
THR B 403
ILE B 405
GLY B 180
ALA B 208
 None
 1.00A 1utdO-6btmB:
undetectable
1utdP-6btmB:
undetectable		 1utdO-6btmB:
undetectable
1utdP-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd 26S PROTEASOME
SUBUNIT S5A

(Rattus
norvegicus) 		no annotation 5 ALA W  93
HIS W 105
ILE W 109
GLY W 102
ALA W  96
 None
 1.02A 1utdO-6epdW:
undetectable
1utdP-6epdW:
undetectable		 1utdO-6epdW:
undetectable
1utdP-6epdW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ALA A 239
HIS A 233
THR A 234
GLY A 123
THR A 182
 None
 0.99A 1utdO-6fc0A:
undetectable
1utdP-6fc0A:
undetectable		 1utdO-6fc0A:
undetectable
1utdP-6fc0A:
undetectable