SIMILAR PATTERNS OF AMINO ACIDS FOR 1UTD_M_TRPM81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		5 THR A 125
HIS A 129
THR A 126
ARG A 100
THR A 252
 PLP  A1000 ( 4.5A)
None
PLP  A1000 ( 4.8A)
PLP  A1000 (-3.8A)
None
 1.34A 1utdM-1c7gA:
undetectable
1utdN-1c7gA:
undetectable		 1utdM-1c7gA:
12.25
1utdN-1c7gA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.06A 1utdM-1l5jA:
undetectable
1utdN-1l5jA:
undetectable		 1utdM-1l5jA:
7.07
1utdN-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 THR A 688
HIS A 652
THR A 655
ILE A 679
THR A 591
 None
 1.36A 1utdM-1lzxA:
undetectable
1utdN-1lzxA:
undetectable		 1utdM-1lzxA:
10.02
1utdN-1lzxA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 THR A 457
HIS A 421
THR A 424
ILE A 448
THR A 360
 None
 1.36A 1utdM-1m9qA:
0.0
1utdN-1m9qA:
0.0		 1utdM-1m9qA:
9.88
1utdN-1m9qA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 GLY B 156
ALA B 151
THR B 139
HIS B 103
THR B 137
 None
 1.29A 1utdM-1mioB:
0.0
1utdN-1mioB:
undetectable		 1utdM-1mioB:
9.76
1utdN-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 GLY A 116
ALA A 262
THR A 123
ILE A 102
SER A 121
 MG  A 401 (-3.8A)
None
None
None
None
 1.28A 1utdM-1n0wA:
0.0
1utdN-1n0wA:
0.0		 1utdM-1n0wA:
14.40
1utdN-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.16A 1utdM-1q8fA:
undetectable
1utdN-1q8fA:
undetectable		 1utdM-1q8fA:
13.50
1utdN-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 188
ALA A 196
THR A  49
THR A 183
THR A  40
 None
 1.12A 1utdM-1v9cA:
undetectable
1utdN-1v9cA:
0.0		 1utdM-1v9cA:
19.25
1utdN-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 GLY A  92
THR A  91
ILE A  13
ARG A  86
THR A  61
 None
 1.15A 1utdM-1vm7A:
undetectable
1utdN-1vm7A:
undetectable		 1utdM-1vm7A:
12.22
1utdN-1vm7A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 GLY A  15
ALA A  23
THR A 252
ILE A  13
SER A 495
 FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
None
 1.04A 1utdM-1yy5A:
undetectable
1utdN-1yy5A:
undetectable		 1utdM-1yy5A:
9.73
1utdN-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0f RAB14, MEMBER RAS
ONCOGENE FAMILY

(Homo sapiens) 		PF00071
(Ras) 		5 GLY A  86
ALA A 109
THR A 117
ILE A 119
ARG A  82
 None
 0.99A 1utdM-1z0fA:
undetectable
1utdN-1z0fA:
undetectable		 1utdM-1z0fA:
16.57
1utdN-1z0fA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 GLY A 238
HIS A 237
THR A 172
ILE A 183
THR A 271
 None
None
FLC  A 501 (-4.7A)
None
ZN  A 500 ( 4.4A)
 1.23A 1utdM-1zb7A:
undetectable
1utdN-1zb7A:
undetectable		 1utdM-1zb7A:
9.28
1utdN-1zb7A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 GLY A 326
HIS A 325
ALA A 275
THR A 211
HIS A 208
 None
 1.31A 1utdM-1zbrA:
undetectable
1utdN-1zbrA:
undetectable		 1utdM-1zbrA:
11.24
1utdN-1zbrA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 GLY A 227
THR A 186
HIS A 185
THR A 184
ILE A 226
 None
 1.19A 1utdM-1zwxA:
undetectable
1utdN-1zwxA:
undetectable		 1utdM-1zwxA:
13.62
1utdN-1zwxA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 GLY A 458
ALA A 455
ILE A 457
ARG A 358
THR A 351
 None
 1.36A 1utdM-2b3oA:
undetectable
1utdN-2b3oA:
undetectable		 1utdM-2b3oA:
10.15
1utdN-2b3oA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.95A 1utdM-2dw4A:
undetectable
1utdN-2dw4A:
undetectable		 1utdM-2dw4A:
8.15
1utdN-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT

(Escherichia
coli) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		5 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 1utdM-2f1fA:
undetectable
1utdN-2f1fA:
undetectable		 1utdM-2f1fA:
20.48
1utdN-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 GLY B 677
ALA B 688
THR B 417
HIS B 682
ILE B 676
 None
None
None
NI  B 901 (-2.8A)
None
 1.06A 1utdM-2fffB:
undetectable
1utdN-2fffB:
undetectable		 1utdM-2fffB:
11.03
1utdN-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 1utdM-2ftpA:
undetectable
1utdN-2ftpA:
undetectable		 1utdM-2ftpA:
12.42
1utdN-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A  23
HIS A  59
ALA A  87
HIS A  58
ILE A  25
 None
 0.89A 1utdM-2i3aA:
undetectable
1utdN-2i3aA:
undetectable		 1utdM-2i3aA:
12.78
1utdN-2i3aA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 GLY A 215
ALA A 239
THR A  26
THR A 217
ILE A 243
 ADP  A 301 (-3.2A)
None
None
None
ADP  A 301 (-4.1A)
 1.29A 1utdM-2i5bA:
undetectable
1utdN-2i5bA:
undetectable		 1utdM-2i5bA:
18.03
1utdN-2i5bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  90
ALA A  96
THR A 297
ILE A  92
SER A  98
 None
 1.34A 1utdM-2o56A:
undetectable
1utdN-2o56A:
undetectable		 1utdM-2o56A:
11.99
1utdN-2o56A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		5 GLY A  55
HIS A 157
THR A  11
THR A 154
ILE A  57
 None
 1.33A 1utdM-2ok8A:
undetectable
1utdN-2ok8A:
undetectable		 1utdM-2ok8A:
12.05
1utdN-2ok8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prx THIOESTERASE
SUPERFAMILY PROTEIN

(Shewanella
loihica) 		PF03061
(4HBT) 		5 GLY A 117
HIS A  68
ALA A  76
THR A  39
ILE A 119
 None
 1.36A 1utdM-2prxA:
undetectable
1utdN-2prxA:
undetectable		 1utdM-2prxA:
18.54
1utdN-2prxA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
GSP  A 401 (-3.6A)
None
 1.35A 1utdM-2q1yA:
undetectable
1utdN-2q1yA:
undetectable		 1utdM-2q1yA:
12.94
1utdN-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ALA A 111
THR A  61
HIS A  62
THR A 124
ILE A 153
 None
None
ZN  A 501 (-3.3A)
None
None
 1.17A 1utdM-2qt3A:
undetectable
1utdN-2qt3A:
undetectable		 1utdM-2qt3A:
14.29
1utdN-2qt3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 569
HIS A 571
THR A 580
THR A 579
ILE A 568
 PG4  A1595 (-4.3A)
PG4  A1595 ( 3.7A)
PG4  A1595 (-4.1A)
PG4  A1595 (-3.9A)
PG4  A1595 (-4.4A)
 1.23A 1utdM-2v6oA:
undetectable
1utdN-2v6oA:
undetectable		 1utdM-2v6oA:
8.02
1utdN-2v6oA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
 None
None
ZN  A1566 (-3.5A)
None
None
 1.24A 1utdM-2w9mA:
undetectable
1utdN-2w9mA:
undetectable		 1utdM-2w9mA:
8.00
1utdN-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 435
ALA A 407
THR A 442
THR A 439
SER A 402
 ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
None
 1.27A 1utdM-2xzlA:
undetectable
1utdN-2xzlA:
undetectable		 1utdM-2xzlA:
7.24
1utdN-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8u CHITIN DEACETYLASE

(Aspergillus
nidulans) 		PF01522
(Polysacc_deac_1) 		5 GLY A  95
THR A 223
HIS A  92
THR A  69
ARG A  67
 None
 1.19A 1utdM-2y8uA:
undetectable
1utdN-2y8uA:
undetectable		 1utdM-2y8uA:
14.60
1utdN-2y8uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.28A 1utdM-2zy2A:
undetectable
1utdN-2zy2A:
undetectable		 1utdM-2zy2A:
8.61
1utdN-2zy2A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.32A 1utdM-3a1nA:
undetectable
1utdN-3a1nA:
undetectable		 1utdM-3a1nA:
13.02
1utdN-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 166
ALA A 194
THR A 284
ILE A 187
THR A 295
 None
 1.06A 1utdM-3b9gA:
undetectable
1utdN-3b9gA:
undetectable		 1utdM-3b9gA:
13.11
1utdN-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 GLY A 258
HIS A 243
ALA A 218
ILE A 234
ARG A 290
 None
 1.33A 1utdM-3dc8A:
undetectable
1utdN-3dc8A:
undetectable		 1utdM-3dc8A:
10.52
1utdN-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		5 GLY A 116
HIS A  79
THR A  77
ILE A 117
ARG A  83
 None
 1.28A 1utdM-3dt8A:
undetectable
1utdN-3dt8A:
undetectable		 1utdM-3dt8A:
15.02
1utdN-3dt8A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A 111
ALA A 117
THR A 138
ILE A 110
SER A 115
 None
 1.29A 1utdM-3e7dA:
undetectable
1utdN-3e7dA:
undetectable		 1utdM-3e7dA:
17.31
1utdN-3e7dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 GLY A 208
ALA A 212
THR A 239
HIS A 204
SER A 214
 None
 1.33A 1utdM-3eegA:
undetectable
1utdN-3eegA:
undetectable		 1utdM-3eegA:
17.23
1utdN-3eegA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori) 		PF04371
(PAD_porph) 		5 GLY A 320
HIS A 319
ALA A 270
THR A 205
HIS A 202
 None
 1.31A 1utdM-3hvmA:
undetectable
1utdN-3hvmA:
undetectable		 1utdM-3hvmA:
13.98
1utdN-3hvmA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 GLY A 117
HIS A 113
HIS A 246
ILE A 120
ARG A 555
 None
CYN  A 900 (-4.1A)
None
None
None
 1.22A 1utdM-3i04A:
undetectable
1utdN-3i04A:
undetectable		 1utdM-3i04A:
7.87
1utdN-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 GLY A 117
HIS A 113
THR A 249
HIS A 246
ARG A 555
 None
CYN  A 900 (-4.1A)
None
None
None
 1.36A 1utdM-3i04A:
undetectable
1utdN-3i04A:
undetectable		 1utdM-3i04A:
7.87
1utdN-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 GLY A  86
ALA A  94
THR A 246
ILE A  84
SER A 322
 AHZ  A 500 (-3.0A)
None
None
None
None
 1.17A 1utdM-3jskA:
undetectable
1utdN-3jskA:
undetectable		 1utdM-3jskA:
13.37
1utdN-3jskA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		5 GLY A 192
THR A 151
HIS A 150
THR A 149
ILE A 191
 None
 1.15A 1utdM-3k55A:
undetectable
1utdN-3k55A:
undetectable		 1utdM-3k55A:
13.73
1utdN-3k55A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		5 GLY A  58
ALA A 109
HIS A  85
ILE A 128
SER A 107
 None
 1.20A 1utdM-3ktoA:
undetectable
1utdN-3ktoA:
undetectable		 1utdM-3ktoA:
18.94
1utdN-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 GLY A  88
HIS A  87
ALA A 102
THR A  81
ILE A 104
 None
 1.20A 1utdM-3l6cA:
undetectable
1utdN-3l6cA:
undetectable		 1utdM-3l6cA:
14.11
1utdN-3l6cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A  88
HIS A  87
ALA A 102
THR A  81
ILE A 104
 None
 1.21A 1utdM-3l6rA:
undetectable
1utdN-3l6rA:
undetectable		 1utdM-3l6rA:
12.84
1utdN-3l6rA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  14
ALA A 325
THR A 304
ILE A 135
ARG A 319
 None
 1.32A 1utdM-3l8kA:
undetectable
1utdN-3l8kA:
undetectable		 1utdM-3l8kA:
11.76
1utdN-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.26A 1utdM-3l8kA:
undetectable
1utdN-3l8kA:
undetectable		 1utdM-3l8kA:
11.76
1utdN-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 GLY A 237
HIS A 234
ALA A 173
THR A 416
THR A 194
 None
 1.19A 1utdM-3q8nA:
undetectable
1utdN-3q8nA:
undetectable		 1utdM-3q8nA:
9.98
1utdN-3q8nA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.19A 1utdM-3rwbA:
undetectable
1utdN-3rwbA:
undetectable		 1utdM-3rwbA:
16.06
1utdN-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Bacillus
anthracis) 		PF00908
(dTDP_sugar_isom) 		5 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 1utdM-3rykA:
2.2
1utdN-3rykA:
2.3		 1utdM-3rykA:
18.40
1utdN-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 HIS A 235
ALA A 212
HIS A 236
ILE A 208
SER A 214
 ZN  A 461 (-3.4A)
None
None
None
None
 1.23A 1utdM-3tqoA:
undetectable
1utdN-3tqoA:
undetectable		 1utdM-3tqoA:
10.75
1utdN-3tqoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 124
HIS A 130
THR A 132
ILE A 122
SER A  58
 None
 1.19A 1utdM-3txxA:
undetectable
1utdN-3txxA:
undetectable		 1utdM-3txxA:
11.21
1utdN-3txxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcq FERREDOXIN

(Cyanidioschyzon
merolae) 		PF00111
(Fer2) 		5 GLY A  50
HIS A  91
THR A  77
ILE A  88
ARG A  41
 None
 1.37A 1utdM-3wcqA:
undetectable
1utdN-3wcqA:
undetectable		 1utdM-3wcqA:
25.25
1utdN-3wcqA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLY A 133
HIS A 151
THR A 152
ILE A 134
SER A 148
 None
 1.19A 1utdM-3wpeA:
undetectable
1utdN-3wpeA:
undetectable		 1utdM-3wpeA:
7.17
1utdN-3wpeA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 GLY A 209
HIS A 388
THR A 387
ILE A 208
THR A 213
 None
FMN  A 500 (-4.6A)
None
None
FMN  A 500 ( 4.6A)
 1.15A 1utdM-3x0yA:
undetectable
1utdN-3x0yA:
undetectable		 1utdM-3x0yA:
11.36
1utdN-3x0yA:
11.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
None
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.28A 1utdM-3zteA:
14.2
1utdN-3zteA:
14.3		 1utdM-3zteA:
78.21
1utdN-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.37A 1utdM-3zzlA:
13.1
1utdN-3zzlA:
13.1		 1utdM-3zzlA:
71.43
1utdN-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.21A 1utdM-3zzqA:
13.6
1utdN-3zzqA:
13.6		 1utdM-3zzqA:
80.00
1utdN-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.23A 1utdM-3zzsA:
13.4
1utdN-3zzsA:
13.5		 1utdM-3zzsA:
100.00
1utdN-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 228
HIS A 313
THR A 318
THR A 314
SER A 322
 NAP  A1447 (-3.2A)
NAP  A1447 (-4.3A)
None
NAP  A1447 (-4.6A)
None
 1.31A 1utdM-4a0sA:
undetectable
1utdN-4a0sA:
undetectable		 1utdM-4a0sA:
10.76
1utdN-4a0sA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ALA A 320
THR A 377
HIS A 249
THR A 250
ILE A 315
 None
None
HEM  A1715 (-3.9A)
None
None
 1.25A 1utdM-4aj9A:
undetectable
1utdN-4aj9A:
undetectable		 1utdM-4aj9A:
8.76
1utdN-4aj9A:
8.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 1utdM-4b27A:
13.1
1utdN-4b27A:
13.1		 1utdM-4b27A:
76.32
1utdN-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bu0 S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF12738
(PTCB-BRCT) 		5 HIS A  46
ALA A  34
ILE A  75
ARG A  37
THR A  45
 GOL  A1187 (-4.7A)
None
None
None
GOL  A1187 ( 3.9A)
 1.19A 1utdM-4bu0A:
undetectable
1utdN-4bu0A:
undetectable		 1utdM-4bu0A:
16.76
1utdN-4bu0A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		5 GLY A 462
HIS A 457
ALA A 259
HIS A 455
ARG A 172
 None
None
FAD  A1449 (-4.9A)
None
FAD  A1449 (-3.9A)
 1.30A 1utdM-4bv6A:
undetectable
1utdN-4bv6A:
undetectable		 1utdM-4bv6A:
9.71
1utdN-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 ALA A 500
THR A 572
THR A 545
ILE A 547
SER A 504
 None
 1.12A 1utdM-4bx9A:
undetectable
1utdN-4bx9A:
undetectable		 1utdM-4bx9A:
7.91
1utdN-4bx9A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 GLY A 124
HIS A 123
ALA A 138
THR A 117
ILE A 140
 None
 1.11A 1utdM-4d9iA:
undetectable
1utdN-4d9iA:
undetectable		 1utdM-4d9iA:
11.42
1utdN-4d9iA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 SO4  A 607 (-3.4A)
None
None
SO4  A 607 (-4.3A)
None
 1.26A 1utdM-4e6eA:
undetectable
1utdN-4e6eA:
undetectable		 1utdM-4e6eA:
12.06
1utdN-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ALA A  69
HIS A  54
THR A  55
ILE A  57
THR A  76
 None
 1.21A 1utdM-4fc7A:
undetectable
1utdN-4fc7A:
undetectable		 1utdM-4fc7A:
16.60
1utdN-4fc7A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 GLY A 389
ALA A 397
THR A 626
ILE A 387
SER A 811
 FAD  A 901 (-3.3A)
None
None
None
None
 0.99A 1utdM-4hsuA:
undetectable
1utdN-4hsuA:
undetectable		 1utdM-4hsuA:
7.64
1utdN-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 GLY B 191
THR B 340
THR B 339
ILE B 194
THR B 169
 None
 1.03A 1utdM-4i6mB:
undetectable
1utdN-4i6mB:
undetectable		 1utdM-4i6mB:
11.93
1utdN-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre IMMUNOGLOBULIN
GAMMA-2A, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  33
ALA B  79
THR B  53
ILE B  51
SER B  77
 None
 1.04A 1utdM-4jreB:
1.6
1utdN-4jreB:
undetectable		 1utdM-4jreB:
15.89
1utdN-4jreB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 HIS A  66
ALA A 103
THR A  44
THR A  40
ILE A  34
 None
 1.24A 1utdM-4kpoA:
undetectable
1utdN-4kpoA:
undetectable		 1utdM-4kpoA:
15.07
1utdN-4kpoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 GLY E 470
HIS E 472
THR E 481
THR E 480
ILE E 469
 None
 1.15A 1utdM-4kprE:
undetectable
1utdN-4kprE:
undetectable		 1utdM-4kprE:
9.64
1utdN-4kprE:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
 FMT  A 501 (-3.4A)
None
None
None
None
 1.28A 1utdM-4kv7A:
undetectable
1utdN-4kv7A:
undetectable		 1utdM-4kv7A:
13.40
1utdN-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 GLY A 433
ALA A 421
THR A 381
ILE A 431
ARG A 374
 None
 1.31A 1utdM-4nhoA:
undetectable
1utdN-4nhoA:
undetectable		 1utdM-4nhoA:
9.43
1utdN-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6i NUCLEOPROTEIN

(Lymphocytic
choriomeningitis
mammarenavirus) 		PF17290
(Arena_ncap_C) 		5 GLY A 385
HIS A 424
ALA A 519
ILE A 383
ARG A 485
 None
 1.29A 1utdM-4o6iA:
undetectable
1utdN-4o6iA:
undetectable		 1utdM-4o6iA:
13.91
1utdN-4o6iA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.25A 1utdM-4ohtA:
undetectable
1utdN-4ohtA:
undetectable		 1utdM-4ohtA:
9.89
1utdN-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		5 GLY A 213
ALA A 217
THR A 244
HIS A 209
SER A 219
 None
None
None
ZN  A 401 ( 3.4A)
None
 1.15A 1utdM-4ov4A:
undetectable
1utdN-4ov4A:
undetectable		 1utdM-4ov4A:
11.11
1utdN-4ov4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 GLY A  84
ALA A  71
HIS A 119
THR A 115
THR A  87
 None
 1.35A 1utdM-4q0gA:
undetectable
1utdN-4q0gA:
undetectable		 1utdM-4q0gA:
9.33
1utdN-4q0gA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A3045
HIS A3071
THR A3057
ILE A2993
ARG A3060
 None
 1.36A 1utdM-4qyrA:
undetectable
1utdN-4qyrA:
undetectable		 1utdM-4qyrA:
7.32
1utdN-4qyrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 GLY A 232
ALA A 209
THR A 122
THR A 231
ILE A 236
 None
 1.31A 1utdM-5dmhA:
undetectable
1utdN-5dmhA:
undetectable		 1utdM-5dmhA:
9.45
1utdN-5dmhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 245
ALA A  85
THR A 244
ILE A 240
SER A  87
 None
None
None
None
PLP  A 501 (-3.7A)
 1.31A 1utdM-5dx5A:
undetectable
1utdN-5dx5A:
undetectable		 1utdM-5dx5A:
11.50
1utdN-5dx5A:
11.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 None
 0.25A 1utdM-5eexA:
15.4
1utdN-5eexA:
15.4		 1utdM-5eexA:
100.00
1utdN-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans) 		PF00344
(SecY) 		5 GLY Y 178
ALA Y 185
THR Y  21
ILE Y 182
THR Y 412
 None
 1.30A 1utdM-5eulY:
undetectable
1utdN-5eulY:
undetectable		 1utdM-5eulY:
10.61
1utdN-5eulY:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9p ANTHRONE
OXIDASE-LIKE PROTEIN

(Streptomyces
ambofaciens) 		PF03992
(ABM) 		5 GLY A 117
HIS A 226
THR A  48
ILE A 116
SER A 229
 None
 1.37A 1utdM-5f9pA:
undetectable
1utdN-5f9pA:
undetectable		 1utdM-5f9pA:
15.35
1utdN-5f9pA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 GLY A  83
HIS A  87
THR A 105
THR A 108
ILE A 112
 None
 1.26A 1utdM-5habA:
undetectable
1utdN-5habA:
undetectable		 1utdM-5habA:
12.91
1utdN-5habA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		5 GLY B1459
HIS B1548
THR B1539
HIS B1546
ILE B1458
 None
 1.22A 1utdM-5hzkB:
undetectable
1utdN-5hzkB:
undetectable		 1utdM-5hzkB:
9.11
1utdN-5hzkB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		5 GLY A 609
THR A  58
THR A  55
ARG A  86
THR A 162
 C8E  A 702 ( 4.0A)
None
None
None
None
 1.36A 1utdM-5ivaA:
undetectable
1utdN-5ivaA:
undetectable		 1utdM-5ivaA:
8.31
1utdN-5ivaA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A 901 (-3.3A)
None
None
None
None
 0.97A 1utdM-5l3dA:
undetectable
1utdN-5l3dA:
undetectable		 1utdM-5l3dA:
6.27
1utdN-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgc ARCE4A

(Arthrobacter
sp. AW19M34-1) 		PF01522
(Polysacc_deac_1) 		5 GLY A  80
THR A 199
HIS A  77
THR A  54
ILE A 118
 None
 1.11A 1utdM-5lgcA:
undetectable
1utdN-5lgcA:
undetectable		 1utdM-5lgcA:
17.89
1utdN-5lgcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls4 NUCLEOPROTEIN

(Mopeia
mammarenavirus) 		PF17290
(Arena_ncap_C) 		5 GLY A 393
HIS A 432
ALA A 531
ILE A 391
ARG A 493
 None
 1.34A 1utdM-5ls4A:
undetectable
1utdN-5ls4A:
undetectable		 1utdM-5ls4A:
15.84
1utdN-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 GLY A 172
ALA A 180
THR A 190
ILE A 175
SER A 186
 None
 1.19A 1utdM-5o1mA:
undetectable
1utdN-5o1mA:
undetectable		 1utdM-5o1mA:
12.64
1utdN-5o1mA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 874
ALA A 726
THR A 846
ILE A 696
SER A 724
 None
None
None
None
SO4  A2003 (-2.4A)
 1.17A 1utdM-5ux5A:
undetectable
1utdN-5ux5A:
undetectable		 1utdM-5ux5A:
5.76
1utdN-5ux5A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 GLY A 568
HIS A 570
THR A 579
THR A 578
ILE A 567
 None
 1.19A 1utdM-5w1jA:
undetectable
1utdN-5w1jA:
undetectable		 1utdM-5w1jA:
8.72
1utdN-5w1jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLY A 147
ALA A 622
HIS A 626
THR A 627
ILE A 148
 SO4  A 706 ( 4.4A)
None
SO4  A 706 (-3.9A)
None
None
 1.17A 1utdM-5y6rA:
undetectable
1utdN-5y6rA:
undetectable		 1utdM-5y6rA:
undetectable
1utdN-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLY A 147
ALA A 622
THR A 627
ILE A 148
SER A 618
 SO4  A 706 ( 4.4A)
None
None
None
None
 1.33A 1utdM-5y6rA:
undetectable
1utdN-5y6rA:
undetectable		 1utdM-5y6rA:
undetectable
1utdN-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 GLY A 126
ALA A 133
THR A 122
THR A 124
ILE A 159
 PO4  A 504 (-4.5A)
None
None
PO4  A 504 (-3.6A)
None
 1.06A 1utdM-5ygrA:
undetectable
1utdN-5ygrA:
undetectable		 1utdM-5ygrA:
undetectable
1utdN-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 GLY A  34
ALA A  60
THR A  35
ILE A  71
SER A  58
 None
 1.24A 1utdM-5z73A:
undetectable
1utdN-5z73A:
undetectable		 1utdM-5z73A:
undetectable
1utdN-5z73A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 GLY A 134
HIS A 152
THR A 153
ILE A 135
SER A 149
 None
 1.14A 1utdM-5zlnA:
undetectable
1utdN-5zlnA:
undetectable		 1utdM-5zlnA:
undetectable
1utdN-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2v TERB OXIDOREDUCTASE

(Streptomyces) 		no annotation 5 GLY A 237
HIS A 219
ALA A 170
ARG A 277
THR A 282
 None
 1.32A 1utdM-6d2vA:
undetectable
1utdN-6d2vA:
undetectable		 1utdM-6d2vA:
undetectable
1utdN-6d2vA:
undetectable