SIMILAR PATTERNS OF AMINO ACIDS FOR 1UTD_L_TRPL81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY C  56
HIS B  39
ALA C  99
ILE C 112
GLY C  40
 None
 1.00A 1utdL-1a5lC:
undetectable
1utdM-1a5lC:
undetectable		 1utdL-1a5lC:
9.36
1utdM-1a5lC:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 ALA A 585
THR A 596
ILE A 639
GLY A 593
ALA A 588
 None
 0.95A 1utdL-1c30A:
0.3
1utdM-1c30A:
0.7		 1utdL-1c30A:
5.50
1utdM-1c30A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 HIS A 209
THR A 115
ILE A 205
GLY A  78
ALA A 123
 None
 0.91A 1utdL-1dgfA:
0.0
1utdM-1dgfA:
undetectable		 1utdL-1dgfA:
9.73
1utdM-1dgfA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		5 GLY A 120
THR A 271
ILE A 118
GLY A 227
ALA A 232
 None
 0.94A 1utdL-1hi9A:
undetectable
1utdM-1hi9A:
0.3		 1utdL-1hi9A:
15.08
1utdM-1hi9A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 ALA A 204
THR A 192
ILE A 208
GLY A 157
ALA A 198
 None
 0.97A 1utdL-1oy1A:
undetectable
1utdM-1oy1A:
undetectable		 1utdL-1oy1A:
16.00
1utdM-1oy1A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 GLY A  69
ALA A  83
ILE A  85
GLY A  46
ALA A  76
 None
 0.98A 1utdL-1pweA:
undetectable
1utdM-1pweA:
undetectable		 1utdL-1pweA:
13.98
1utdM-1pweA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		5 GLY A 108
HIS A 142
HIS A  80
ILE A  84
GLY A 144
 None
None
None
None
BME  A 302 (-3.3A)
 1.02A 1utdL-1t8hA:
undetectable
1utdM-1t8hA:
undetectable		 1utdL-1t8hA:
13.00
1utdM-1t8hA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 GLY B 209
HIS B 219
THR B 223
ILE B 248
GLY B 262
 None
MGM  B 379 (-3.7A)
None
None
None
 0.95A 1utdL-1tnuB:
undetectable
1utdM-1tnuB:
undetectable		 1utdL-1tnuB:
12.68
1utdM-1tnuB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		5 GLY A 296
ALA A 197
HIS A 194
ILE A 291
GLY A 193
 None
 0.73A 1utdL-1wd3A:
undetectable
1utdM-1wd3A:
undetectable		 1utdL-1wd3A:
9.13
1utdM-1wd3A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLY A 250
HIS A 249
HIS A 247
THR A 245
ILE A 243
 None
 1.01A 1utdL-2b24A:
undetectable
1utdM-2b24A:
undetectable		 1utdL-2b24A:
9.29
1utdM-2b24A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		5 GLY A 537
THR A 659
HIS A 534
THR A 510
GLY A 533
 None
 0.99A 1utdL-2c79A:
undetectable
1utdM-2c79A:
undetectable		 1utdL-2c79A:
14.85
1utdM-2c79A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		5 ALA A  22
ILE A  67
GLY A  14
THR A 189
SER A  18
 None
None
SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
 0.93A 1utdL-2detA:
undetectable
1utdM-2detA:
undetectable		 1utdL-2detA:
11.89
1utdM-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.98A 1utdL-2dw4A:
undetectable
1utdM-2dw4A:
undetectable		 1utdL-2dw4A:
8.15
1utdM-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 ALA A  80
THR A 124
THR A 121
GLY A 187
THR A 189
 None
None
DGL  A 278 (-3.6A)
None
DGL  A 278 (-3.0A)
 0.96A 1utdL-2dwuA:
undetectable
1utdM-2dwuA:
undetectable		 1utdL-2dwuA:
16.50
1utdM-2dwuA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 GLY A 309
ALA A 325
GLY A 477
SER A 323
ALA A 324
 None
 0.90A 1utdL-2ehqA:
undetectable
1utdM-2ehqA:
undetectable		 1utdL-2ehqA:
9.82
1utdM-2ehqA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 GLY B 677
ALA B 688
THR B 417
HIS B 682
ILE B 676
 None
None
None
NI  B 901 (-2.8A)
None
 1.00A 1utdL-2fffB:
undetectable
1utdM-2fffB:
undetectable		 1utdL-2fffB:
11.03
1utdM-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		5 GLY A 221
ALA A 205
ILE A 219
GLY A 138
ALA A 177
 None
 0.96A 1utdL-2fn9A:
undetectable
1utdM-2fn9A:
undetectable		 1utdL-2fn9A:
16.13
1utdM-2fn9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 GLY A  96
HIS A  92
ALA A  25
ILE A  99
SER A  29
 EDO  A 277 (-3.4A)
None
None
None
None
 1.03A 1utdL-2ftzA:
undetectable
1utdM-2ftzA:
undetectable		 1utdL-2ftzA:
16.55
1utdM-2ftzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		5 GLY A 107
HIS A 106
THR A 202
THR A 237
GLY A 172
 None
None
MN  A   1 ( 3.7A)
None
None
 0.91A 1utdL-2gtxA:
undetectable
1utdM-2gtxA:
undetectable		 1utdL-2gtxA:
18.59
1utdM-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 ALA A  77
THR A 121
THR A 118
GLY A 184
THR A 186
 None
None
DGL  A 501 (-3.6A)
None
DGL  A 501 (-3.0A)
 0.99A 1utdL-2gzmA:
undetectable
1utdM-2gzmA:
undetectable		 1utdL-2gzmA:
13.75
1utdM-2gzmA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		5 ALA A  75
THR A 119
THR A 116
GLY A 183
THR A 185
 None
None
DGL  A1267 (-3.7A)
None
DGL  A1267 (-2.8A)
 0.98A 1utdL-2jfqA:
undetectable
1utdM-2jfqA:
undetectable		 1utdL-2jfqA:
16.22
1utdM-2jfqA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 ALA A 273
THR A 252
HIS A 199
ILE A 203
ALA A 276
 None
 1.02A 1utdL-2o2cA:
undetectable
1utdM-2o2cA:
undetectable		 1utdL-2o2cA:
9.57
1utdM-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 HIS A 230
ALA A 273
THR A 252
HIS A 199
ILE A 203
 None
 0.93A 1utdL-2o2cA:
undetectable
1utdM-2o2cA:
undetectable		 1utdL-2o2cA:
9.57
1utdM-2o2cA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		5 GLY C 207
HIS C 206
ALA C 260
HIS C 222
ALA C 261
 None
 0.95A 1utdL-2p9nC:
undetectable
1utdM-2p9nC:
undetectable		 1utdL-2p9nC:
11.08
1utdM-2p9nC:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 271
ALA A 284
ILE A 275
GLY A 314
ALA A 285
 None
 1.01A 1utdL-2pgwA:
undetectable
1utdM-2pgwA:
undetectable		 1utdL-2pgwA:
9.87
1utdM-2pgwA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 GLY A  72
HIS A  71
ALA A  19
THR A  98
ILE A  66
 None
 0.97A 1utdL-2qcvA:
undetectable
1utdM-2qcvA:
undetectable		 1utdL-2qcvA:
15.70
1utdM-2qcvA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A 174
ALA A 275
HIS A 205
GLY A 203
ALA A 226
 PLP  A 400 ( 3.3A)
PLP  A 400 ( 4.0A)
None
None
None
 0.95A 1utdL-2rkbA:
undetectable
1utdM-2rkbA:
undetectable		 1utdL-2rkbA:
12.38
1utdM-2rkbA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhe ACETYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep) 		5 HIS A 134
ILE A 129
GLY A 172
SER A 157
ALA A 139
 None
None
COA  A 300 (-3.5A)
None
None
 0.95A 1utdL-2vheA:
undetectable
1utdM-2vheA:
undetectable		 1utdL-2vheA:
15.62
1utdM-2vheA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		5 ALA A  77
THR A 121
THR A 118
GLY A 184
THR A 186
 None
None
DGL  A1270 (-3.6A)
None
DGL  A1270 (-3.0A)
 0.98A 1utdL-2vvtA:
undetectable
1utdM-2vvtA:
undetectable		 1utdL-2vvtA:
12.76
1utdM-2vvtA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x75 ADENYLOSUCCINATE
LYASE

(Staphylococcus
aureus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 GLY A 286
ALA A 227
ILE A 288
GLY A 279
ALA A 230
 None
 0.96A 1utdL-2x75A:
undetectable
1utdM-2x75A:
undetectable		 1utdL-2x75A:
10.67
1utdM-2x75A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8u CHITIN DEACETYLASE

(Aspergillus
nidulans) 		PF01522
(Polysacc_deac_1) 		5 GLY A  95
THR A 223
HIS A  92
THR A  69
GLY A  91
 None
 0.95A 1utdL-2y8uA:
undetectable
1utdM-2y8uA:
undetectable		 1utdL-2y8uA:
14.60
1utdM-2y8uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 125
THR A 332
GLY A 289
SER A 300
ALA A 266
 None
 0.97A 1utdL-2zviA:
0.5
1utdM-2zviA:
undetectable		 1utdL-2zviA:
10.43
1utdM-2zviA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1523
THR A1367
GLY A1305
THR A1312
ALA A1338
 None
 0.96A 1utdL-3av6A:
undetectable
1utdM-3av6A:
undetectable		 1utdL-3av6A:
4.82
1utdM-3av6A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.99A 1utdL-3d8xA:
undetectable
1utdM-3d8xA:
undetectable		 1utdL-3d8xA:
13.12
1utdM-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF03740
(PdxJ) 		5 GLY A  41
ALA A  34
THR A  67
ILE A  42
ALA A  37
 None
 0.98A 1utdL-3f4nA:
undetectable
1utdM-3f4nA:
undetectable		 1utdL-3f4nA:
13.58
1utdM-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		5 GLY A 251
ALA A 107
THR A 247
ILE A 204
GLY A 332
 None
 0.96A 1utdL-3fmqA:
undetectable
1utdM-3fmqA:
undetectable		 1utdL-3fmqA:
13.14
1utdM-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 THR A  92
ILE A  96
GLY A 117
SER A 269
ALA A 270
 PRP  A 401 (-4.2A)
None
PRP  A 401 (-3.2A)
None
None
 1.01A 1utdL-3gbrA:
undetectable
1utdM-3gbrA:
undetectable		 1utdL-3gbrA:
14.29
1utdM-3gbrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A 155
ALA A 146
ILE A 198
GLY A 103
ALA A 145
 None
 1.01A 1utdL-3gvcA:
undetectable
1utdM-3gvcA:
undetectable		 1utdL-3gvcA:
13.97
1utdM-3gvcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 GLY A 363
ALA A 352
THR A 378
ILE A 359
GLY A 396
 None
 0.95A 1utdL-3iwjA:
undetectable
1utdM-3iwjA:
undetectable		 1utdL-3iwjA:
10.54
1utdM-3iwjA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 GLY A 363
ALA A 352
THR A 378
ILE A 359
GLY A 396
 None
 0.93A 1utdL-3iwkA:
undetectable
1utdM-3iwkA:
undetectable		 1utdL-3iwkA:
10.34
1utdM-3iwkA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3w 50S RIBOSOMAL
PROTEIN L15

(Bacillus
subtilis) 		PF00828
(Ribosomal_L27A) 		5 ALA L 132
THR L 142
ILE L 111
GLY L 140
ALA L 135
 None
 1.02A 1utdL-3j3wL:
undetectable
1utdM-3j3wL:
undetectable		 1utdL-3j3wL:
19.40
1utdM-3j3wL:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY A 326
HIS A 170
ALA A 370
ILE A 385
GLY A 310
 None
 0.87A 1utdL-3la4A:
undetectable
1utdM-3la4A:
undetectable		 1utdL-3la4A:
6.68
1utdM-3la4A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		6 GLY A 229
ALA A 224
THR A 177
GLY A 239
SER A 222
ALA A 223
 None
 1.46A 1utdL-3qomA:
undetectable
1utdM-3qomA:
undetectable		 1utdL-3qomA:
11.23
1utdM-3qomA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 120
ALA A 111
HIS A 108
GLY A  94
ALA A  97
 None
None
ZN  A 186 (-3.3A)
None
None
 0.96A 1utdL-3s6lA:
undetectable
1utdM-3s6lA:
undetectable		 1utdL-3s6lA:
18.71
1utdM-3s6lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7z PUTATIVE ASPARTATE
RACEMASE

(Salmonella
enterica) 		PF01177
(Asp_Glu_race) 		5 ALA A  86
THR A 127
THR A 124
GLY A 192
THR A 194
 None
None
SIN  A 300 (-4.0A)
None
SIN  A 300 (-3.3A)
 0.99A 1utdL-3s7zA:
undetectable
1utdM-3s7zA:
undetectable		 1utdL-3s7zA:
12.92
1utdM-3s7zA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ALA A 124
THR A  14
ILE A  12
GLY A  94
SER A 120
 None
None
None
NAP  A 601 (-3.2A)
None
 1.03A 1utdL-3toxA:
undetectable
1utdM-3toxA:
undetectable		 1utdL-3toxA:
15.71
1utdM-3toxA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trh PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CARBOXYLTRANSFERASE
SUBUNIT

(Coxiella
burnetii) 		PF00731
(AIRC) 		5 GLY A  86
THR A 115
ILE A  85
GLY A 118
ALA A  22
 None
 0.97A 1utdL-3trhA:
undetectable
1utdM-3trhA:
undetectable		 1utdL-3trhA:
18.79
1utdM-3trhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpy FHA
DOMAIN-CONTAINING
PROTEIN DDL

(Arabidopsis
thaliana) 		PF00498
(FHA) 		5 HIS A  62
THR A  53
ILE A  51
GLY A 120
THR A  96
 None
 0.85A 1utdL-3vpyA:
undetectable
1utdM-3vpyA:
undetectable		 1utdL-3vpyA:
26.74
1utdM-3vpyA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 GLY A 146
ALA A 257
ILE A 272
GLY A 170
ALA A 256
 None
 0.96A 1utdL-3vpzA:
undetectable
1utdM-3vpzA:
undetectable		 1utdL-3vpzA:
12.77
1utdM-3vpzA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.37A 1utdL-3zteA:
14.4
1utdM-3zteA:
14.2		 1utdL-3zteA:
78.21
1utdM-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.44A 1utdL-3zzlA:
12.7
1utdM-3zzlA:
13.1		 1utdL-3zzlA:
71.43
1utdM-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 TRP  A  81 (-3.5A)
TRP  A  81 ( 4.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
TRP  A  81 ( 3.7A)
 1.05A 1utdL-3zzlA:
12.7
1utdM-3zzlA:
13.1		 1utdL-3zzlA:
71.43
1utdM-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.26A 1utdL-3zzqA:
13.2
1utdM-3zzqA:
13.6		 1utdL-3zzqA:
80.00
1utdM-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.26A 1utdL-3zzsA:
13.2
1utdM-3zzsA:
13.4		 1utdL-3zzsA:
100.00
1utdM-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 TRP  A1072 (-3.5A)
TRP  A1072 ( 4.7A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 3.8A)
 1.15A 1utdL-3zzsA:
13.2
1utdM-3zzsA:
13.4		 1utdL-3zzsA:
100.00
1utdM-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 GLY A 360
ALA A 349
THR A 375
ILE A 356
GLY A 393
 None
 1.02A 1utdL-4a0mA:
undetectable
1utdM-4a0mA:
undetectable		 1utdL-4a0mA:
9.68
1utdM-4a0mA:
9.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 1utdL-4b27A:
12.8
1utdM-4b27A:
13.1		 1utdL-4b27A:
76.32
1utdM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.21A 1utdL-4b27A:
12.8
1utdM-4b27A:
13.1		 1utdL-4b27A:
76.32
1utdM-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.80A 1utdL-4cnkA:
undetectable
1utdM-4cnkA:
undetectable		 1utdL-4cnkA:
12.76
1utdM-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLY A 350
ALA A 338
THR A 363
ILE A 346
GLY A 381
 None
None
None
None
GOL  A 600 (-4.6A)
 0.99A 1utdL-4dalA:
undetectable
1utdM-4dalA:
undetectable		 1utdL-4dalA:
9.83
1utdM-4dalA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ALA A 132
THR A 393
THR A 143
GLY A 140
ALA A 135
 None
 0.91A 1utdL-4dioA:
undetectable
1utdM-4dioA:
undetectable		 1utdL-4dioA:
11.11
1utdM-4dioA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 HIS A  26
THR A  23
ILE A  90
GLY A 178
ALA A 154
 None
 1.01A 1utdL-4e13A:
undetectable
1utdM-4e13A:
undetectable		 1utdL-4e13A:
15.81
1utdM-4e13A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo7 METHIONINE
AMINOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF00557
(Peptidase_M24) 		5 GLY A 106
HIS A 105
THR A 201
THR A 236
GLY A 171
 None
None
MN  A 301 ( 3.8A)
None
None
 0.96A 1utdL-4fo7A:
undetectable
1utdM-4fo7A:
undetectable		 1utdL-4fo7A:
15.30
1utdM-4fo7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuk METHIONINE
AMINOPEPTIDASE

(Trypanosoma
brucei) 		PF00557
(Peptidase_M24) 		5 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.01A 1utdL-4fukA:
undetectable
1utdM-4fukA:
undetectable		 1utdL-4fukA:
11.94
1utdM-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.96A 1utdL-4h27A:
undetectable
1utdM-4h27A:
undetectable		 1utdL-4h27A:
13.46
1utdM-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 ( 3.6A)
None
None
 0.99A 1utdL-4hxxA:
undetectable
1utdM-4hxxA:
undetectable		 1utdL-4hxxA:
11.80
1utdM-4hxxA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
 None
 0.97A 1utdL-4i8pA:
undetectable
1utdM-4i8pA:
undetectable		 1utdL-4i8pA:
9.81
1utdM-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 GLY A 364
ALA A 353
THR A 379
ILE A 360
GLY A 397
 None
 0.94A 1utdL-4i8qA:
undetectable
1utdM-4i8qA:
undetectable		 1utdL-4i8qA:
9.01
1utdM-4i8qA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 0.98A 1utdL-4iu6A:
undetectable
1utdM-4iu6A:
undetectable		 1utdL-4iu6A:
12.50
1utdM-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 ACETALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 GLY B 128
ALA B 189
THR B 132
GLY B 182
ALA B 175
 None
 1.00A 1utdL-4jn6B:
undetectable
1utdM-4jn6B:
undetectable		 1utdL-4jn6B:
14.09
1utdM-4jn6B:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		5 GLY A 191
ALA A 119
ILE A 190
GLY A 206
THR A 174
 None
 0.95A 1utdL-4m7gA:
undetectable
1utdM-4m7gA:
undetectable		 1utdL-4m7gA:
17.16
1utdM-4m7gA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE

(Rhodotorula
mucilaginosa) 		PF13561
(adh_short_C2) 		5 ALA A  44
THR A  31
ILE A 111
GLY A  52
ALA A  47
 None
 0.84A 1utdL-4o0lA:
undetectable
1utdM-4o0lA:
undetectable		 1utdL-4o0lA:
15.27
1utdM-4o0lA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		5 GLY A 141
HIS A 140
THR A 236
THR A 271
GLY A 206
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
None
 0.90A 1utdL-4ookA:
undetectable
1utdM-4ookA:
undetectable		 1utdL-4ookA:
13.69
1utdM-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		6 GLY A  84
ALA A  71
HIS A 119
THR A 115
THR A  87
ALA A  68
 None
 1.35A 1utdL-4q0gA:
undetectable
1utdM-4q0gA:
undetectable		 1utdL-4q0gA:
9.33
1utdM-4q0gA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		6 GLY A 673
HIS A 677
ILE A 670
GLY A 646
SER A 638
ALA A 662
 None
 1.37A 1utdL-4u7tA:
undetectable
1utdM-4u7tA:
undetectable		 1utdL-4u7tA:
9.89
1utdM-4u7tA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		5 GLY A  96
HIS A  92
ALA A  25
ILE A  99
SER A  29
 None
 0.97A 1utdL-4wk5A:
undetectable
1utdM-4wk5A:
undetectable		 1utdL-4wk5A:
14.19
1utdM-4wk5A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1521
THR A1364
GLY A1302
THR A1309
ALA A1335
 None
 0.86A 1utdL-4wxxA:
undetectable
1utdM-4wxxA:
undetectable		 1utdL-4wxxA:
4.84
1utdM-4wxxA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus musculus) 		PF01370
(Epimerase) 		5 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
 None
 1.01A 1utdL-4yraA:
undetectable
1utdM-4yraA:
undetectable		 1utdL-4yraA:
12.91
1utdM-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		5 GLY A 358
ALA A 347
THR A 375
ILE A 354
GLY A 393
 None
 0.97A 1utdL-4zwlA:
undetectable
1utdM-4zwlA:
undetectable		 1utdL-4zwlA:
9.48
1utdM-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 ALA A  79
THR A  90
ILE A  58
GLY A  87
ALA A  82
 None
 0.91A 1utdL-5a5gA:
undetectable
1utdM-5a5gA:
undetectable		 1utdL-5a5gA:
10.41
1utdM-5a5gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		5 GLY A 115
ALA A 105
THR A 245
HIS A 248
ALA A 217
 None
 1.03A 1utdL-5b7nA:
undetectable
1utdM-5b7nA:
undetectable		 1utdL-5b7nA:
15.74
1utdM-5b7nA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A   6
HIS A 194
ILE A   5
GLY A 196
ALA A 244
 None
 0.96A 1utdL-5cdeA:
undetectable
1utdM-5cdeA:
undetectable		 1utdL-5cdeA:
10.71
1utdM-5cdeA:
10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 None
 0.28A 1utdL-5eexA:
14.9
1utdM-5eexA:
15.4		 1utdL-5eexA:
100.00
1utdM-5eexA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 None
 1.17A 1utdL-5eexA:
14.9
1utdM-5eexA:
15.4		 1utdL-5eexA:
100.00
1utdM-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 GLY A 422
HIS A 423
HIS A 455
THR A 203
ALA A 480
 None
ZN  A 702 (-3.2A)
ZN  A 702 ( 3.1A)
None
None
 1.00A 1utdL-5ficA:
undetectable
1utdM-5ficA:
undetectable		 1utdL-5ficA:
9.11
1utdM-5ficA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 GLY A 220
ALA A 236
THR A 208
GLY A 202
ALA A 232
 None
 0.97A 1utdL-5i2hA:
undetectable
1utdM-5i2hA:
undetectable		 1utdL-5i2hA:
12.43
1utdM-5i2hA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 GLY A 232
ALA A 180
ILE A 236
GLY A  83
ALA A 181
 2OH  A 402 ( 3.8A)
2OH  A 402 ( 3.8A)
None
None
2OH  A 402 (-3.9A)
 0.86A 1utdL-5it1A:
undetectable
1utdM-5it1A:
undetectable		 1utdL-5it1A:
9.04
1utdM-5it1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN

(Mamastrovirus
1;
Mus musculus) 		PF12226
(Astro_capsid_p)
PF07686
(V-set) 		5 GLY C  49
HIS C  35
THR A 461
GLY C 101
SER A 463
 None
 1.00A 1utdL-5kovC:
undetectable
1utdM-5kovC:
undetectable		 1utdL-5kovC:
15.16
1utdM-5kovC:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A 901 (-3.3A)
None
None
None
None
 1.00A 1utdL-5l3dA:
undetectable
1utdM-5l3dA:
undetectable		 1utdL-5l3dA:
6.27
1utdM-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgc ARCE4A

(Arthrobacter
sp. AW19M34-1) 		PF01522
(Polysacc_deac_1) 		6 GLY A  80
THR A 199
HIS A  77
THR A  54
ILE A 118
GLY A  76
 None
 1.03A 1utdL-5lgcA:
undetectable
1utdM-5lgcA:
undetectable		 1utdL-5lgcA:
17.89
1utdM-5lgcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 5 GLY A 335
ALA A 379
THR A 361
GLY A 383
ALA A 380
 None
 0.99A 1utdL-5oj3A:
undetectable
1utdM-5oj3A:
undetectable		 1utdL-5oj3A:
undetectable
1utdM-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 GLY A 165
ALA A 103
THR A  21
ILE A 168
ALA A 104
 None
 0.97A 1utdL-5sy4A:
undetectable
1utdM-5sy4A:
undetectable		 1utdL-5sy4A:
17.62
1utdM-5sy4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 5 GLY A 225
THR A 278
ILE A 269
GLY A  22
THR A  20
 None
 0.89A 1utdL-5u6fA:
2.2
1utdM-5u6fA:
1.9		 1utdL-5u6fA:
undetectable
1utdM-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 765
ALA A 781
GLY A 933
SER A 779
ALA A 780
 None
 0.88A 1utdL-5ur2A:
undetectable
1utdM-5ur2A:
undetectable		 1utdL-5ur2A:
6.57
1utdM-5ur2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE

(Azospirillum
brasilense) 		PF00171
(Aldedh) 		5 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.93A 1utdL-5x5tA:
undetectable
1utdM-5x5tA:
undetectable		 1utdL-5x5tA:
10.44
1utdM-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivorans) 		no annotation 5 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
 None
 1.03A 1utdL-5yapA:
undetectable
1utdM-5yapA:
undetectable		 1utdL-5yapA:
undetectable
1utdM-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z72 CCPC

(Bacillus
velezensis) 		no annotation 5 ILE A 218
GLY A 148
THR A 262
SER A 129
ALA A  98
 FLC  A 303 ( 4.5A)
None
None
FLC  A 303 ( 2.1A)
FLC  A 303 (-3.1A)
 0.95A 1utdL-5z72A:
undetectable
1utdM-5z72A:
undetectable		 1utdL-5z72A:
undetectable
1utdM-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 5 GLY A  30
ALA A 255
ILE A  34
GLY A 351
SER A 355
 None
 1.03A 1utdL-6bn2A:
undetectable
1utdM-6bn2A:
undetectable		 1utdL-6bn2A:
undetectable
1utdM-6bn2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd 26S PROTEASOME
SUBUNIT S5A

(Rattus
norvegicus) 		no annotation 5 ALA W  93
HIS W 105
ILE W 109
GLY W 102
ALA W  96
 None
 0.99A 1utdL-6epdW:
undetectable
1utdM-6epdW:
undetectable		 1utdL-6epdW:
undetectable
1utdM-6epdW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ALA A 239
HIS A 233
THR A 234
GLY A 123
THR A 182
 None
 1.01A 1utdL-6fc0A:
0.6
1utdM-6fc0A:
undetectable		 1utdL-6fc0A:
undetectable
1utdM-6fc0A:
undetectable