SIMILAR PATTERNS OF AMINO ACIDS FOR 1UTD_J_TRPJ81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 213
THR A  32
ILE A   4
SER A  58
 None
 0.78A 1utdJ-1ajkA:
0.0
1utdK-1ajkA:
0.3		 1utdJ-1ajkA:
16.82
1utdK-1ajkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.76A 1utdJ-1ajoA:
0.0
1utdK-1ajoA:
0.0		 1utdJ-1ajoA:
18.54
1utdK-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.75A 1utdJ-1axkA:
1.1
1utdK-1axkA:
0.9		 1utdJ-1axkA:
11.17
1utdK-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 118
ALA A  25
THR A 125
THR A  82
 None
 0.72A 1utdJ-1c3xA:
undetectable
1utdK-1c3xA:
0.0		 1utdJ-1c3xA:
14.98
1utdK-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.76A 1utdJ-1cpnA:
1.0
1utdK-1cpnA:
0.8		 1utdJ-1cpnA:
15.35
1utdK-1cpnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLY A  39
THR A  43
ILE A 411
THR A  48
 None
 0.81A 1utdJ-1d9zA:
0.0
1utdK-1d9zA:
0.0		 1utdJ-1d9zA:
7.86
1utdK-1d9zA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.72A 1utdJ-1f26A:
0.0
1utdK-1f26A:
0.0		 1utdJ-1f26A:
11.72
1utdK-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.64A 1utdJ-1flgA:
0.0
1utdK-1flgA:
0.0		 1utdJ-1flgA:
8.63
1utdK-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 ALA A 131
HIS A  77
ILE A 138
THR A  82
 None
 0.80A 1utdJ-1gw1A:
undetectable
1utdK-1gw1A:
undetectable		 1utdJ-1gw1A:
14.09
1utdK-1gw1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3q SEDLIN

(Mus musculus) 		PF04628
(Sedlin_N) 		4 GLY A  11
THR A  77
HIS A  80
ILE A   9
 None
 0.78A 1utdJ-1h3qA:
undetectable
1utdK-1h3qA:
0.8		 1utdJ-1h3qA:
19.12
1utdK-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 GLY A  11
ALA A  20
ILE A  33
THR A 428
 FAD  A 579 (-3.1A)
None
None
None
 0.76A 1utdJ-1h81A:
undetectable
1utdK-1h81A:
undetectable		 1utdJ-1h81A:
9.76
1utdK-1h81A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.13A 1utdJ-1l5jA:
undetectable
1utdK-1l5jA:
undetectable		 1utdJ-1l5jA:
7.07
1utdK-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 GLY A 307
ALA A 313
ILE A 309
SER A 315
 None
 0.70A 1utdJ-1l8wA:
undetectable
1utdK-1l8wA:
undetectable		 1utdJ-1l8wA:
11.14
1utdK-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PO4  A 655 (-3.6A)
None
None
None
 0.81A 1utdJ-1lw3A:
undetectable
1utdK-1lw3A:
undetectable		 1utdJ-1lw3A:
7.46
1utdK-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 THR A 688
HIS A 652
THR A 655
ILE A 679
THR A 591
 None
 1.34A 1utdJ-1lzxA:
undetectable
1utdK-1lzxA:
undetectable		 1utdJ-1lzxA:
10.02
1utdK-1lzxA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 THR A 457
HIS A 421
THR A 424
ILE A 448
THR A 360
 None
 1.33A 1utdJ-1m9qA:
undetectable
1utdK-1m9qA:
undetectable		 1utdJ-1m9qA:
9.88
1utdK-1m9qA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.80A 1utdJ-1macA:
undetectable
1utdK-1macA:
undetectable		 1utdJ-1macA:
17.79
1utdK-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 GLY B 156
ALA B 151
THR B 139
HIS B 103
THR B 137
 None
 1.30A 1utdJ-1mioB:
undetectable
1utdK-1mioB:
undetectable		 1utdJ-1mioB:
9.76
1utdK-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.78A 1utdJ-1mlzA:
undetectable
1utdK-1mlzA:
undetectable		 1utdJ-1mlzA:
12.63
1utdK-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 GLY A 116
ALA A 262
THR A 123
ILE A 102
SER A 121
 MG  A 401 (-3.8A)
None
None
None
None
 1.29A 1utdJ-1n0wA:
undetectable
1utdK-1n0wA:
undetectable		 1utdJ-1n0wA:
14.40
1utdK-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ob1 ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  33
ALA B  24
THR B  52
ILE B  34
 None
 0.79A 1utdJ-1ob1B:
undetectable
1utdK-1ob1B:
undetectable		 1utdJ-1ob1B:
12.50
1utdK-1ob1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 105
ALA Q  96
THR Q  99
THR Q 376
 None
 0.74A 1utdJ-1oh2Q:
undetectable
1utdK-1oh2Q:
undetectable		 1utdJ-1oh2Q:
12.04
1utdK-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
 None
 1.39A 1utdJ-1ps9A:
undetectable
1utdK-1ps9A:
undetectable		 1utdJ-1ps9A:
8.10
1utdK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1utdJ-1ptjA:
undetectable
1utdK-1ptjA:
undetectable		 1utdJ-1ptjA:
13.14
1utdK-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.08A 1utdJ-1q8fA:
undetectable
1utdK-1q8fA:
undetectable		 1utdJ-1q8fA:
13.50
1utdK-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 GLY A  10
ALA A  23
ILE A  36
THR A 312
 None
 0.80A 1utdJ-1qmhA:
undetectable
1utdK-1qmhA:
undetectable		 1utdJ-1qmhA:
15.23
1utdK-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 188
ALA A 196
THR A  49
THR A 183
THR A  40
 None
 1.14A 1utdJ-1v9cA:
undetectable
1utdK-1v9cA:
undetectable		 1utdJ-1v9cA:
19.25
1utdK-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.80A 1utdJ-1vb4A:
0.5
1utdK-1vb4A:
undetectable		 1utdJ-1vb4A:
14.55
1utdK-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 GLY A 296
ALA A 183
THR A 291
ILE A 298
 None
 0.81A 1utdJ-1vliA:
undetectable
1utdK-1vliA:
undetectable		 1utdJ-1vliA:
13.01
1utdK-1vliA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 GLY A  90
ALA A 121
THR A 104
ILE A  91
SER A  98
 None
 1.37A 1utdJ-1vpxA:
undetectable
1utdK-1vpxA:
undetectable		 1utdJ-1vpxA:
18.53
1utdK-1vpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 GLY A 296
ALA A 197
HIS A 194
ILE A 291
 None
 0.67A 1utdJ-1wd3A:
undetectable
1utdK-1wd3A:
undetectable		 1utdJ-1wd3A:
9.13
1utdK-1wd3A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.63A 1utdJ-1wkmA:
undetectable
1utdK-1wkmA:
undetectable		 1utdJ-1wkmA:
15.29
1utdK-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.74A 1utdJ-1x9jA:
undetectable
1utdK-1x9jA:
undetectable		 1utdJ-1x9jA:
13.28
1utdK-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.75A 1utdJ-1y6jA:
undetectable
1utdK-1y6jA:
undetectable		 1utdJ-1y6jA:
15.48
1utdK-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 ALA A  23
HIS A 480
THR A 252
ILE A  13
SER A 495
 None
None
FAD  A 803 (-4.6A)
None
None
 1.29A 1utdJ-1yy5A:
undetectable
1utdK-1yy5A:
undetectable		 1utdJ-1yy5A:
9.73
1utdK-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 GLY A  15
ALA A  23
THR A 252
ILE A  13
SER A 495
 FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
None
 0.96A 1utdJ-1yy5A:
undetectable
1utdK-1yy5A:
undetectable		 1utdJ-1yy5A:
9.73
1utdK-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 GLY A 341
THR A 376
ILE A 340
THR A 200
SER A 209
 None
 1.26A 1utdJ-1z6rA:
undetectable
1utdK-1z6rA:
undetectable		 1utdJ-1z6rA:
11.00
1utdK-1z6rA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.75A 1utdJ-1zsqA:
undetectable
1utdK-1zsqA:
undetectable		 1utdJ-1zsqA:
12.02
1utdK-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 GLY A 227
THR A 186
HIS A 185
THR A 184
ILE A 226
 None
 1.24A 1utdJ-1zwxA:
undetectable
1utdK-1zwxA:
undetectable		 1utdJ-1zwxA:
13.62
1utdK-1zwxA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLY A 152
THR A 143
ILE A 163
THR A 399
 None
 0.77A 1utdJ-2ahwA:
undetectable
1utdK-2ahwA:
undetectable		 1utdJ-2ahwA:
9.98
1utdK-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.77A 1utdJ-2amhA:
undetectable
1utdK-2amhA:
undetectable		 1utdJ-2amhA:
19.19
1utdK-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.88A 1utdJ-2dw4A:
undetectable
1utdK-2dw4A:
undetectable		 1utdJ-2dw4A:
8.15
1utdK-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.72A 1utdJ-2e28A:
undetectable
1utdK-2e28A:
undetectable		 1utdJ-2e28A:
9.86
1utdK-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 182
ALA A 208
THR A 185
THR A 319
 NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
 0.73A 1utdJ-2eerA:
undetectable
1utdK-2eerA:
undetectable		 1utdJ-2eerA:
13.02
1utdK-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 GLY B 677
ALA B 688
THR B 417
HIS B 682
ILE B 676
 None
None
None
NI  B 901 (-2.8A)
None
 1.11A 1utdJ-2fffB:
undetectable
1utdK-2fffB:
undetectable		 1utdJ-2fffB:
11.03
1utdK-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 GLY A 145
ALA A  92
THR A  84
ILE A 149
 None
 0.80A 1utdJ-2g02A:
undetectable
1utdK-2g02A:
undetectable		 1utdJ-2g02A:
9.83
1utdK-2g02A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 GLY A 215
ALA A 239
THR A  26
THR A 217
ILE A 243
 ADP  A 301 (-3.2A)
None
None
None
ADP  A 301 (-4.1A)
 1.28A 1utdJ-2i5bA:
undetectable
1utdK-2i5bA:
undetectable		 1utdJ-2i5bA:
18.03
1utdK-2i5bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		4 GLY A 200
ALA A 208
ILE A 198
THR A  25
 None
 0.78A 1utdJ-2ij9A:
undetectable
1utdK-2ij9A:
undetectable		 1utdJ-2ij9A:
17.14
1utdK-2ij9A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.57A 1utdJ-2jifA:
undetectable
1utdK-2jifA:
undetectable		 1utdJ-2jifA:
10.55
1utdK-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  90
ALA A  96
THR A 297
ILE A  92
SER A  98
 None
 1.36A 1utdJ-2o56A:
undetectable
1utdK-2o56A:
undetectable		 1utdJ-2o56A:
11.99
1utdK-2o56A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		5 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1utdJ-2p5uA:
undetectable
1utdK-2p5uA:
undetectable		 1utdJ-2p5uA:
12.68
1utdK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF14597
(Lactamase_B_5) 		4 ALA A  70
THR A  77
THR A  79
ILE A  81
 None
 0.74A 1utdJ-2p97A:
undetectable
1utdK-2p97A:
undetectable		 1utdJ-2p97A:
18.13
1utdK-2p97A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
GSP  A 401 (-3.6A)
None
 1.36A 1utdJ-2q1yA:
undetectable
1utdK-2q1yA:
undetectable		 1utdJ-2q1yA:
12.94
1utdK-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ALA A 111
THR A  61
HIS A  62
THR A 124
ILE A 153
 None
None
ZN  A 501 (-3.3A)
None
None
 1.14A 1utdJ-2qt3A:
undetectable
1utdK-2qt3A:
undetectable		 1utdJ-2qt3A:
14.29
1utdK-2qt3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 GLY A 358
THR A 207
ILE A 361
SER A 337
 None
 0.70A 1utdJ-2qveA:
undetectable
1utdK-2qveA:
undetectable		 1utdJ-2qveA:
11.96
1utdK-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.69A 1utdJ-2vq0A:
0.6
1utdK-2vq0A:
undetectable		 1utdJ-2vq0A:
13.28
1utdK-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 ALA A 368
THR A   4
THR A  50
ILE A 385
 None
 0.79A 1utdJ-2vunA:
undetectable
1utdK-2vunA:
undetectable		 1utdJ-2vunA:
12.90
1utdK-2vunA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
 None
None
ZN  A1566 (-3.5A)
None
None
 1.20A 1utdJ-2w9mA:
undetectable
1utdK-2w9mA:
undetectable		 1utdJ-2w9mA:
8.00
1utdK-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.81A 1utdJ-2wghA:
undetectable
1utdK-2wghA:
undetectable		 1utdJ-2wghA:
8.38
1utdK-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 435
ALA A 407
THR A 442
THR A 439
SER A 402
 ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
None
 1.21A 1utdJ-2xzlA:
undetectable
1utdK-2xzlA:
undetectable		 1utdJ-2xzlA:
7.24
1utdK-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 GLY A 124
ALA A 221
ILE A 218
SER A 225
 None
 0.77A 1utdJ-2yikA:
undetectable
1utdK-2yikA:
undetectable		 1utdJ-2yikA:
8.51
1utdK-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ALA A  60
HIS A  83
THR A  84
SER A  62
 None
 0.78A 1utdJ-2yk0A:
undetectable
1utdK-2yk0A:
undetectable		 1utdJ-2yk0A:
6.32
1utdK-2yk0A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.35A 1utdJ-3a1nA:
undetectable
1utdK-3a1nA:
undetectable		 1utdJ-3a1nA:
13.02
1utdK-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
 None
 1.25A 1utdJ-3b4wA:
undetectable
1utdK-3b4wA:
undetectable		 1utdJ-3b4wA:
10.29
1utdK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 166
ALA A 194
THR A 284
ILE A 187
THR A 295
 None
 1.00A 1utdJ-3b9gA:
undetectable
1utdK-3b9gA:
undetectable		 1utdJ-3b9gA:
13.11
1utdK-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.80A 1utdJ-3cb5A:
undetectable
1utdK-3cb5A:
undetectable		 1utdJ-3cb5A:
9.95
1utdK-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 GLY A 110
HIS A 134
THR A 135
ILE A 164
 None
 0.68A 1utdJ-3cq5A:
undetectable
1utdK-3cq5A:
undetectable		 1utdJ-3cq5A:
13.50
1utdK-3cq5A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A 111
ALA A 117
THR A 138
ILE A 110
SER A 115
 None
 1.28A 1utdJ-3e7dA:
undetectable
1utdK-3e7dA:
undetectable		 1utdJ-3e7dA:
17.31
1utdK-3e7dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 GLY A 270
ALA A 238
THR A 267
ILE A 235
THR A 173
 None
None
None
None
MYR  A 315 ( 4.9A)
 1.39A 1utdJ-3ee4A:
undetectable
1utdK-3ee4A:
undetectable		 1utdJ-3ee4A:
12.95
1utdK-3ee4A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 GLY A 208
ALA A 212
THR A 239
HIS A 204
SER A 214
 None
 1.37A 1utdJ-3eegA:
undetectable
1utdK-3eegA:
undetectable		 1utdJ-3eegA:
17.23
1utdK-3eegA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 1utdJ-3f2bA:
undetectable
1utdK-3f2bA:
undetectable		 1utdJ-3f2bA:
6.36
1utdK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.80A 1utdJ-3f2bA:
undetectable
1utdK-3f2bA:
undetectable		 1utdJ-3f2bA:
6.36
1utdK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		4 GLY A 149
ALA A  38
THR A 134
THR A 145
 None
 0.63A 1utdJ-3faoA:
undetectable
1utdK-3faoA:
undetectable		 1utdJ-3faoA:
18.44
1utdK-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.75A 1utdJ-3fmqA:
undetectable
1utdK-3fmqA:
undetectable		 1utdJ-3fmqA:
13.14
1utdK-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.78A 1utdJ-3fpzA:
undetectable
1utdK-3fpzA:
undetectable		 1utdJ-3fpzA:
16.03
1utdK-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.70A 1utdJ-3hhsB:
undetectable
1utdK-3hhsB:
undetectable		 1utdJ-3hhsB:
8.46
1utdK-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 174
ALA A 140
THR A 457
ILE A 173
THR A 442
 None
 1.18A 1utdJ-3hpaA:
undetectable
1utdK-3hpaA:
undetectable		 1utdJ-3hpaA:
10.65
1utdK-3hpaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 GLY A 393
THR A 355
ILE A 394
THR A 189
SER A 342
 None
 1.37A 1utdJ-3hq2A:
undetectable
1utdK-3hq2A:
undetectable		 1utdJ-3hq2A:
8.96
1utdK-3hq2A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		4 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.78A 1utdJ-3i4iA:
undetectable
1utdK-3i4iA:
undetectable		 1utdJ-3i4iA:
16.44
1utdK-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9g SONEPCIZUMAB
ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  78
HIS H  32
ILE H  51
SER H  24
 None
 0.79A 1utdJ-3i9gH:
undetectable
1utdK-3i9gH:
1.5		 1utdJ-3i9gH:
12.83
1utdK-3i9gH:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 GLY A 116
THR A  70
HIS A 121
SER A  66
 None
 0.59A 1utdJ-3ihaA:
undetectable
1utdK-3ihaA:
undetectable		 1utdJ-3ihaA:
7.68
1utdK-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  31
ALA A   8
THR A  87
ILE A  81
 None
 0.80A 1utdJ-3ip1A:
undetectable
1utdK-3ip1A:
undetectable		 1utdJ-3ip1A:
11.50
1utdK-3ip1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 GLY A  86
ALA A  94
THR A 246
ILE A  84
SER A 322
 AHZ  A 500 (-3.0A)
None
None
None
None
 1.13A 1utdJ-3jskA:
undetectable
1utdK-3jskA:
undetectable		 1utdJ-3jskA:
13.37
1utdK-3jskA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		5 GLY A 192
THR A 151
HIS A 150
THR A 149
ILE A 191
 None
 1.21A 1utdJ-3k55A:
undetectable
1utdK-3k55A:
undetectable		 1utdJ-3k55A:
13.73
1utdK-3k55A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		5 GLY A  58
ALA A 109
HIS A  85
ILE A 128
SER A 107
 None
 1.22A 1utdJ-3ktoA:
undetectable
1utdK-3ktoA:
undetectable		 1utdJ-3ktoA:
18.94
1utdK-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		4 GLY A  23
ALA A 123
THR A 200
ILE A  22
 None
 0.81A 1utdJ-3kwpA:
undetectable
1utdK-3kwpA:
undetectable		 1utdJ-3kwpA:
15.00
1utdK-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Homo sapiens) 		PF01409
(tRNA-synt_2d) 		5 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.45A 1utdJ-3l4gA:
undetectable
1utdK-3l4gA:
undetectable		 1utdJ-3l4gA:
9.81
1utdK-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liu PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 GLY A  68
ALA A 122
HIS A 104
ILE A  78
 None
 0.75A 1utdJ-3liuA:
1.6
1utdK-3liuA:
undetectable		 1utdJ-3liuA:
12.19
1utdK-3liuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		4 GLY A 147
THR A 204
HIS A 130
ILE A 146
 None
 0.78A 1utdJ-3mdqA:
undetectable
1utdK-3mdqA:
undetectable		 1utdJ-3mdqA:
14.24
1utdK-3mdqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 466
ALA A 403
THR A 442
ILE A 467
 None
EDO  A 619 (-3.5A)
None
None
 0.78A 1utdJ-3mosA:
undetectable
1utdK-3mosA:
undetectable		 1utdJ-3mosA:
8.81
1utdK-3mosA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.67A 1utdJ-3myxA:
3.9
1utdK-3myxA:
4.0		 1utdJ-3myxA:
16.88
1utdK-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz2 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 GLY A  63
ALA A 149
THR A 157
ILE A  90
 None
 0.81A 1utdJ-3mz2A:
undetectable
1utdK-3mz2A:
undetectable		 1utdJ-3mz2A:
16.07
1utdK-3mz2A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 143
ALA A  82
HIS A  76
ILE A 105
 None
 0.75A 1utdJ-3o04A:
undetectable
1utdK-3o04A:
undetectable		 1utdJ-3o04A:
12.22
1utdK-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.73A 1utdJ-3or2B:
undetectable
1utdK-3or2B:
undetectable		 1utdJ-3or2B:
11.35
1utdK-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.48A 1utdJ-3q88A:
undetectable
1utdK-3q88A:
undetectable		 1utdJ-3q88A:
10.28
1utdK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 GLY A  94
ALA A  41
HIS A  38
ILE A  93
 None
 0.77A 1utdJ-3qbdA:
undetectable
1utdK-3qbdA:
undetectable		 1utdJ-3qbdA:
14.20
1utdK-3qbdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 GLY M 125
ILE M   7
THR M  94
SER M  43
 None
 0.80A 1utdJ-3rkoM:
undetectable
1utdK-3rkoM:
undetectable		 1utdJ-3rkoM:
9.84
1utdK-3rkoM:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.77A 1utdJ-3rotA:
undetectable
1utdK-3rotA:
undetectable		 1utdJ-3rotA:
13.47
1utdK-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.23A 1utdJ-3rwbA:
undetectable
1utdK-3rwbA:
undetectable		 1utdJ-3rwbA:
16.06
1utdK-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLY A  53
ALA A 251
THR A 274
ILE A 248
 None
 0.78A 1utdJ-3snhA:
undetectable
1utdK-3snhA:
undetectable		 1utdJ-3snhA:
6.70
1utdK-3snhA:
6.70