SIMILAR PATTERNS OF AMINO ACIDS FOR 1UTD_B_TRPB81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 213
THR A  32
ILE A   4
SER A  58
 None
 0.76A 1utdB-1ajkA:
0.3
1utdC-1ajkA:
0.1		 1utdB-1ajkA:
16.82
1utdC-1ajkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.77A 1utdB-1ajoA:
1.1
1utdC-1ajoA:
1.4		 1utdB-1ajoA:
18.54
1utdC-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.76A 1utdB-1axkA:
1.1
1utdC-1axkA:
1.2		 1utdB-1axkA:
11.17
1utdC-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 118
ALA A  25
THR A 125
THR A  82
 None
 0.74A 1utdB-1c3xA:
undetectable
1utdC-1c3xA:
undetectable		 1utdB-1c3xA:
14.98
1utdC-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.78A 1utdB-1cpnA:
0.9
1utdC-1cpnA:
0.9		 1utdB-1cpnA:
15.35
1utdC-1cpnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLY A  39
THR A  43
ILE A 411
THR A  48
 None
 0.80A 1utdB-1d9zA:
0.0
1utdC-1d9zA:
0.0		 1utdB-1d9zA:
7.86
1utdC-1d9zA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 GLY A  84
HIS A  79
ILE A  86
SER A  76
 None
ZN  A 500 (-3.4A)
None
None
 0.81A 1utdB-1ddkA:
0.0
1utdC-1ddkA:
0.0		 1utdB-1ddkA:
17.04
1utdC-1ddkA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.67A 1utdB-1f26A:
0.0
1utdC-1f26A:
0.0		 1utdB-1f26A:
11.72
1utdC-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.67A 1utdB-1flgA:
0.0
1utdC-1flgA:
0.0		 1utdB-1flgA:
8.63
1utdC-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3q SEDLIN

(Mus musculus) 		PF04628
(Sedlin_N) 		4 GLY A  11
THR A  77
HIS A  80
ILE A   9
 None
 0.79A 1utdB-1h3qA:
undetectable
1utdC-1h3qA:
undetectable		 1utdB-1h3qA:
19.12
1utdC-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 GLY A  11
ALA A  20
ILE A  33
THR A 428
 FAD  A 579 (-3.1A)
None
None
None
 0.78A 1utdB-1h81A:
undetectable
1utdC-1h81A:
undetectable		 1utdB-1h81A:
9.76
1utdC-1h81A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.14A 1utdB-1l5jA:
undetectable
1utdC-1l5jA:
undetectable		 1utdB-1l5jA:
7.07
1utdC-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 GLY A 307
ALA A 313
ILE A 309
SER A 315
 None
 0.66A 1utdB-1l8wA:
undetectable
1utdC-1l8wA:
undetectable		 1utdB-1l8wA:
11.14
1utdC-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 THR A 688
HIS A 652
THR A 655
ILE A 679
THR A 591
 None
 1.36A 1utdB-1lzxA:
undetectable
1utdC-1lzxA:
undetectable		 1utdB-1lzxA:
10.02
1utdC-1lzxA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 THR A 457
HIS A 421
THR A 424
ILE A 448
THR A 360
 None
 1.35A 1utdB-1m9qA:
undetectable
1utdC-1m9qA:
undetectable		 1utdB-1m9qA:
9.88
1utdC-1m9qA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.80A 1utdB-1macA:
undetectable
1utdC-1macA:
undetectable		 1utdB-1macA:
17.79
1utdC-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 GLY B 156
ALA B 151
THR B 139
HIS B 103
THR B 137
 None
 1.36A 1utdB-1mioB:
undetectable
1utdC-1mioB:
undetectable		 1utdB-1mioB:
9.76
1utdC-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.81A 1utdB-1mlzA:
undetectable
1utdC-1mlzA:
undetectable		 1utdB-1mlzA:
12.63
1utdC-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 GLY A 116
ALA A 262
THR A 123
ILE A 102
SER A 121
 MG  A 401 (-3.8A)
None
None
None
None
 1.29A 1utdB-1n0wA:
undetectable
1utdC-1n0wA:
undetectable		 1utdB-1n0wA:
14.40
1utdC-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ob1 ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  33
ALA B  24
THR B  52
ILE B  34
 None
 0.78A 1utdB-1ob1B:
1.5
1utdC-1ob1B:
undetectable		 1utdB-1ob1B:
12.50
1utdC-1ob1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 105
ALA Q  96
THR Q  99
THR Q 376
 None
 0.72A 1utdB-1oh2Q:
undetectable
1utdC-1oh2Q:
undetectable		 1utdB-1oh2Q:
12.04
1utdC-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
 None
 1.41A 1utdB-1ps9A:
undetectable
1utdC-1ps9A:
undetectable		 1utdB-1ps9A:
8.10
1utdC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.71A 1utdB-1ptjA:
undetectable
1utdC-1ptjA:
undetectable		 1utdB-1ptjA:
13.14
1utdC-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 GLY A 152
ALA A 174
THR A 273
ILE A 167
THR A 287
 None
 1.10A 1utdB-1q8fA:
undetectable
1utdC-1q8fA:
undetectable		 1utdB-1q8fA:
13.50
1utdC-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 GLY A  54
ALA A  80
ILE A  58
THR A  87
 None
 0.80A 1utdB-1t5oA:
undetectable
1utdC-1t5oA:
undetectable		 1utdB-1t5oA:
13.33
1utdC-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 188
ALA A 196
THR A  49
THR A 183
THR A  40
 None
 1.14A 1utdB-1v9cA:
undetectable
1utdC-1v9cA:
undetectable		 1utdB-1v9cA:
19.25
1utdC-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 GLY A  90
ALA A 121
THR A 104
ILE A  91
SER A  98
 None
 1.40A 1utdB-1vpxA:
undetectable
1utdC-1vpxA:
undetectable		 1utdB-1vpxA:
18.53
1utdC-1vpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 GLY A 296
ALA A 197
HIS A 194
ILE A 291
 None
 0.68A 1utdB-1wd3A:
undetectable
1utdC-1wd3A:
undetectable		 1utdB-1wd3A:
9.13
1utdC-1wd3A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.66A 1utdB-1wkmA:
undetectable
1utdC-1wkmA:
undetectable		 1utdB-1wkmA:
15.29
1utdC-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.76A 1utdB-1x9jA:
undetectable
1utdC-1x9jA:
undetectable		 1utdB-1x9jA:
13.28
1utdC-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.79A 1utdB-1y6jA:
undetectable
1utdC-1y6jA:
undetectable		 1utdB-1y6jA:
15.48
1utdC-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 GLY A  15
ALA A  23
THR A 252
ILE A  13
SER A 495
 FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
None
 0.97A 1utdB-1yy5A:
undetectable
1utdC-1yy5A:
undetectable		 1utdB-1yy5A:
9.73
1utdC-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 GLY A 341
THR A 376
ILE A 340
THR A 200
SER A 209
 None
 1.29A 1utdB-1z6rA:
undetectable
1utdC-1z6rA:
undetectable		 1utdB-1z6rA:
11.00
1utdC-1z6rA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.77A 1utdB-1zsqA:
undetectable
1utdC-1zsqA:
undetectable		 1utdB-1zsqA:
12.02
1utdC-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 GLY A 227
THR A 186
HIS A 185
THR A 184
ILE A 226
 None
 1.24A 1utdB-1zwxA:
undetectable
1utdC-1zwxA:
undetectable		 1utdB-1zwxA:
13.62
1utdC-1zwxA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLY A 152
THR A 143
ILE A 163
THR A 399
 None
 0.77A 1utdB-2ahwA:
undetectable
1utdC-2ahwA:
undetectable		 1utdB-2ahwA:
9.98
1utdC-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.79A 1utdB-2amhA:
undetectable
1utdC-2amhA:
undetectable		 1utdB-2amhA:
19.19
1utdC-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 GLY A 103
ALA A  61
ILE A  26
THR A  58
 None
 0.79A 1utdB-2c2iA:
undetectable
1utdC-2c2iA:
undetectable		 1utdB-2c2iA:
22.14
1utdC-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.80A 1utdB-2cevA:
undetectable
1utdC-2cevA:
undetectable		 1utdB-2cevA:
14.81
1utdC-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 ALA A  22
ILE A  67
THR A 189
SER A  18
 None
None
None
SO4  A5001 (-2.7A)
 0.79A 1utdB-2detA:
undetectable
1utdC-2detA:
undetectable		 1utdB-2detA:
11.89
1utdC-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.90A 1utdB-2dw4A:
undetectable
1utdC-2dw4A:
undetectable		 1utdB-2dw4A:
8.15
1utdC-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.76A 1utdB-2e28A:
undetectable
1utdC-2e28A:
undetectable		 1utdB-2e28A:
9.86
1utdC-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 182
ALA A 208
THR A 185
THR A 319
 NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
 0.71A 1utdB-2eerA:
undetectable
1utdC-2eerA:
undetectable		 1utdB-2eerA:
13.02
1utdC-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 GLY B 677
ALA B 688
THR B 417
HIS B 682
ILE B 676
 None
None
None
NI  B 901 (-2.8A)
None
 1.10A 1utdB-2fffB:
undetectable
1utdC-2fffB:
undetectable		 1utdB-2fffB:
11.03
1utdC-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 GLY A 145
ALA A  92
THR A  84
ILE A 149
 None
 0.79A 1utdB-2g02A:
undetectable
1utdC-2g02A:
undetectable		 1utdB-2g02A:
9.83
1utdC-2g02A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 GLY A 215
ALA A 239
THR A  26
THR A 217
ILE A 243
 ADP  A 301 (-3.2A)
None
None
None
ADP  A 301 (-4.1A)
 1.29A 1utdB-2i5bA:
undetectable
1utdC-2i5bA:
undetectable		 1utdB-2i5bA:
18.03
1utdC-2i5bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		4 GLY A 200
ALA A 208
ILE A 198
THR A  25
 None
 0.80A 1utdB-2ij9A:
undetectable
1utdC-2ij9A:
undetectable		 1utdB-2ij9A:
17.14
1utdC-2ij9A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.58A 1utdB-2jifA:
undetectable
1utdC-2jifA:
undetectable		 1utdB-2jifA:
10.55
1utdC-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  90
ALA A  96
THR A 297
ILE A  92
SER A  98
 None
 1.33A 1utdB-2o56A:
undetectable
1utdC-2o56A:
undetectable		 1utdB-2o56A:
11.99
1utdC-2o56A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		5 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 1utdB-2p5uA:
undetectable
1utdC-2p5uA:
undetectable		 1utdB-2p5uA:
12.68
1utdC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF14597
(Lactamase_B_5) 		4 ALA A  70
THR A  77
THR A  79
ILE A  81
 None
 0.75A 1utdB-2p97A:
undetectable
1utdC-2p97A:
undetectable		 1utdB-2p97A:
18.13
1utdC-2p97A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
GSP  A 401 (-3.6A)
None
 1.36A 1utdB-2q1yA:
undetectable
1utdC-2q1yA:
undetectable		 1utdB-2q1yA:
12.94
1utdC-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ALA A 111
THR A  61
HIS A  62
THR A 124
ILE A 153
 None
None
ZN  A 501 (-3.3A)
None
None
 1.13A 1utdB-2qt3A:
undetectable
1utdC-2qt3A:
undetectable		 1utdB-2qt3A:
14.29
1utdC-2qt3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 GLY A 358
THR A 207
ILE A 361
SER A 337
 None
 0.72A 1utdB-2qveA:
undetectable
1utdC-2qveA:
undetectable		 1utdB-2qveA:
11.96
1utdC-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.71A 1utdB-2vq0A:
undetectable
1utdC-2vq0A:
undetectable		 1utdB-2vq0A:
13.28
1utdC-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 ALA A 368
THR A   4
THR A  50
ILE A 385
 None
 0.80A 1utdB-2vunA:
undetectable
1utdC-2vunA:
undetectable		 1utdB-2vunA:
12.90
1utdC-2vunA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.79A 1utdB-2wghA:
undetectable
1utdC-2wghA:
undetectable		 1utdB-2wghA:
8.38
1utdC-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 THR A 641
HIS A 620
ILE A 209
SER A 653
 None
 0.77A 1utdB-2xvgA:
undetectable
1utdC-2xvgA:
2.7		 1utdB-2xvgA:
5.10
1utdC-2xvgA:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 435
ALA A 407
THR A 442
THR A 439
SER A 402
 ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
None
 1.24A 1utdB-2xzlA:
undetectable
1utdC-2xzlA:
undetectable		 1utdB-2xzlA:
7.24
1utdC-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 GLY A 124
ALA A 221
ILE A 218
SER A 225
 None
 0.76A 1utdB-2yikA:
undetectable
1utdC-2yikA:
undetectable		 1utdB-2yikA:
8.51
1utdC-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ALA A  60
HIS A  83
THR A  84
SER A  62
 None
 0.76A 1utdB-2yk0A:
undetectable
1utdC-2yk0A:
undetectable		 1utdB-2yk0A:
6.32
1utdC-2yk0A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.35A 1utdB-3a1nA:
undetectable
1utdC-3a1nA:
undetectable		 1utdB-3a1nA:
13.02
1utdC-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
 None
 1.26A 1utdB-3b4wA:
undetectable
1utdC-3b4wA:
undetectable		 1utdB-3b4wA:
10.29
1utdC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 166
ALA A 194
THR A 284
ILE A 187
THR A 295
 None
 1.03A 1utdB-3b9gA:
undetectable
1utdC-3b9gA:
undetectable		 1utdB-3b9gA:
13.11
1utdC-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.80A 1utdB-3cb5A:
undetectable
1utdC-3cb5A:
undetectable		 1utdB-3cb5A:
9.95
1utdC-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 GLY A 110
HIS A 134
THR A 135
ILE A 164
 None
 0.69A 1utdB-3cq5A:
undetectable
1utdC-3cq5A:
undetectable		 1utdB-3cq5A:
13.50
1utdC-3cq5A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A 111
ALA A 117
THR A 138
ILE A 110
SER A 115
 None
 1.29A 1utdB-3e7dA:
undetectable
1utdC-3e7dA:
undetectable		 1utdB-3e7dA:
17.31
1utdC-3e7dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 GLY A 270
ALA A 238
THR A 267
ILE A 235
THR A 173
 None
None
None
None
MYR  A 315 ( 4.9A)
 1.39A 1utdB-3ee4A:
undetectable
1utdC-3ee4A:
undetectable		 1utdB-3ee4A:
12.95
1utdC-3ee4A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 GLY A 208
ALA A 212
THR A 239
HIS A 204
SER A 214
 None
 1.39A 1utdB-3eegA:
undetectable
1utdC-3eegA:
undetectable		 1utdB-3eegA:
17.23
1utdC-3eegA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.43A 1utdB-3f2bA:
undetectable
1utdC-3f2bA:
undetectable		 1utdB-3f2bA:
6.36
1utdC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.81A 1utdB-3f2bA:
undetectable
1utdC-3f2bA:
undetectable		 1utdB-3f2bA:
6.36
1utdC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		4 GLY A 149
ALA A  38
THR A 134
THR A 145
 None
 0.62A 1utdB-3faoA:
undetectable
1utdC-3faoA:
undetectable		 1utdB-3faoA:
18.44
1utdC-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.79A 1utdB-3fmqA:
undetectable
1utdC-3fmqA:
undetectable		 1utdB-3fmqA:
13.14
1utdC-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.81A 1utdB-3fpzA:
undetectable
1utdC-3fpzA:
undetectable		 1utdB-3fpzA:
16.03
1utdC-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A1443
THR A1351
HIS A1279
ILE A1369
SER A1429
 None
 1.30A 1utdB-3greA:
undetectable
1utdC-3greA:
undetectable		 1utdB-3greA:
12.01
1utdC-3greA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 THR A  56
ILE A  54
THR A 173
SER A 141
 NA  A 358 (-4.0A)
None
None
None
 0.78A 1utdB-3h84A:
undetectable
1utdC-3h84A:
undetectable		 1utdB-3h84A:
12.99
1utdC-3h84A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.69A 1utdB-3hhsB:
undetectable
1utdC-3hhsB:
undetectable		 1utdB-3hhsB:
8.46
1utdC-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 174
ALA A 140
THR A 457
ILE A 173
THR A 442
 None
 1.21A 1utdB-3hpaA:
undetectable
1utdC-3hpaA:
undetectable		 1utdB-3hpaA:
10.65
1utdC-3hpaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 GLY A 393
THR A 355
ILE A 394
THR A 189
SER A 342
 None
 1.39A 1utdB-3hq2A:
undetectable
1utdC-3hq2A:
undetectable		 1utdB-3hq2A:
8.96
1utdC-3hq2A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		4 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.80A 1utdB-3i4iA:
undetectable
1utdC-3i4iA:
undetectable		 1utdB-3i4iA:
16.44
1utdC-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 THR A 348
ILE A 321
THR A 249
SER A 345
 None
None
FMN  A1002 (-3.8A)
ORO  A1003 (-3.2A)
 0.79A 1utdB-3i6rA:
undetectable
1utdC-3i6rA:
undetectable		 1utdB-3i6rA:
10.60
1utdC-3i6rA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 GLY A 116
THR A  70
HIS A 121
SER A  66
 None
 0.60A 1utdB-3ihaA:
undetectable
1utdC-3ihaA:
undetectable		 1utdB-3ihaA:
7.68
1utdC-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  31
ALA A   8
THR A  87
ILE A  81
 None
 0.80A 1utdB-3ip1A:
undetectable
1utdC-3ip1A:
undetectable		 1utdB-3ip1A:
11.50
1utdC-3ip1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLY F 366
THR F 364
ILE F 401
THR F 333
 None
 0.80A 1utdB-3jbrF:
undetectable
1utdC-3jbrF:
undetectable		 1utdB-3jbrF:
5.20
1utdC-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 GLY A  86
ALA A  94
THR A 246
ILE A  84
SER A 322
 AHZ  A 500 (-3.0A)
None
None
None
None
 1.13A 1utdB-3jskA:
undetectable
1utdC-3jskA:
undetectable		 1utdB-3jskA:
13.37
1utdC-3jskA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		5 GLY A 192
THR A 151
HIS A 150
THR A 149
ILE A 191
 None
 1.21A 1utdB-3k55A:
undetectable
1utdC-3k55A:
undetectable		 1utdB-3k55A:
13.73
1utdC-3k55A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		5 GLY A  58
ALA A 109
HIS A  85
ILE A 128
SER A 107
 None
 1.24A 1utdB-3ktoA:
undetectable
1utdC-3ktoA:
undetectable		 1utdB-3ktoA:
18.94
1utdC-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Homo sapiens) 		PF01409
(tRNA-synt_2d) 		5 GLY A 458
THR A 328
HIS A 327
ILE A 373
SER A 332
 PHE  A 509 (-3.6A)
None
None
None
None
 1.43A 1utdB-3l4gA:
undetectable
1utdC-3l4gA:
undetectable		 1utdB-3l4gA:
9.81
1utdC-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liu PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 GLY A  68
ALA A 122
HIS A 104
ILE A  78
 None
 0.78A 1utdB-3liuA:
undetectable
1utdC-3liuA:
undetectable		 1utdB-3liuA:
12.19
1utdC-3liuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 466
ALA A 403
THR A 442
ILE A 467
 None
EDO  A 619 (-3.5A)
None
None
 0.79A 1utdB-3mosA:
undetectable
1utdC-3mosA:
undetectable		 1utdB-3mosA:
8.81
1utdC-3mosA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.66A 1utdB-3myxA:
undetectable
1utdC-3myxA:
4.0		 1utdB-3myxA:
16.88
1utdC-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz2 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 GLY A  63
ALA A 149
THR A 157
ILE A  90
 None
 0.81A 1utdB-3mz2A:
undetectable
1utdC-3mz2A:
undetectable		 1utdB-3mz2A:
16.07
1utdC-3mz2A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 143
ALA A  82
HIS A  76
ILE A 105
 None
 0.80A 1utdB-3o04A:
undetectable
1utdC-3o04A:
undetectable		 1utdB-3o04A:
12.22
1utdC-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.78A 1utdB-3or2B:
undetectable
1utdC-3or2B:
undetectable		 1utdB-3or2B:
11.35
1utdC-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		4 ALA A 189
HIS A 178
THR A 177
ILE A 202
 None
CO  A 328 (-3.3A)
None
None
 0.77A 1utdB-3orwA:
undetectable
1utdC-3orwA:
undetectable		 1utdB-3orwA:
14.98
1utdC-3orwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.46A 1utdB-3q88A:
undetectable
1utdC-3q88A:
undetectable		 1utdB-3q88A:
10.28
1utdC-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 GLY A  94
ALA A  41
HIS A  38
ILE A  93
 None
 0.79A 1utdB-3qbdA:
undetectable
1utdC-3qbdA:
undetectable		 1utdB-3qbdA:
14.20
1utdC-3qbdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 GLY M 125
ILE M   7
THR M  94
SER M  43
 None
 0.80A 1utdB-3rkoM:
undetectable
1utdC-3rkoM:
undetectable		 1utdB-3rkoM:
9.84
1utdC-3rkoM:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.77A 1utdB-3rotA:
undetectable
1utdC-3rotA:
undetectable		 1utdB-3rotA:
13.47
1utdC-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.24A 1utdB-3rwbA:
undetectable
1utdC-3rwbA:
undetectable		 1utdB-3rwbA:
16.06
1utdC-3rwbA:
16.06