SIMILAR PATTERNS OF AMINO ACIDS FOR 1URM_A_BEZA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4o PEROXIREDOXIN 5

(Homo sapiens) 		PF08534
(Redoxin) 		8 PRO A  40
THR A  44
PRO A  45
GLY A  46
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.29A 1urmA-1h4oA:
33.8		 1urmA-1h4oA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nm3 PROTEIN HI0572

(Haemophilus
influenzae) 		PF00462
(Glutaredoxin)
PF08534
(Redoxin) 		6 PRO A  42
THR A  46
PRO A  47
LEU A 118
PHE A 120
ARG A 126
 None
 0.89A 1urmA-1nm3A:
23.1		 1urmA-1nm3A:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR

(Homo sapiens;
Homo sapiens) 		PF00386
(C1q)
PF00386
(C1q) 		5 PRO A  93
PRO A 221
GLY A 135
LEU B 220
PHE B 221
 None
 1.50A 1urmA-1pk6A:
undetectable		 1urmA-1pk6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		5 THR A 283
PRO A 284
GLY A 285
LEU A  78
ARG A  46
 None
 1.31A 1urmA-1tklA:
undetectable		 1urmA-1tklA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		5 PRO A 112
PRO A 121
SER A 118
LEU A  25
THR A 114
 None
 1.45A 1urmA-1wlsA:
undetectable		 1urmA-1wlsA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y25 PROBABLE THIOL
PEROXIDASE

(Mycobacterium
tuberculosis) 		PF08534
(Redoxin) 		5 PRO A  53
THR A  57
PRO A  58
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.50A 1urmA-1y25A:
19.1		 1urmA-1y25A:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y25 PROBABLE THIOL
PEROXIDASE

(Mycobacterium
tuberculosis) 		PF08534
(Redoxin) 		5 PRO A  53
THR A  57
PRO A  58
SER A  60
LEU A   6
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-2.8A)
None
 1.10A 1urmA-1y25A:
19.1		 1urmA-1y25A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 THR A 420
GLY A 519
SER A 419
LEU A 436
PHE A 447
 None
 1.39A 1urmA-1y9gA:
undetectable		 1urmA-1y9gA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA) 		6 PRO A 100
THR A 104
PRO A 105
GLY A 106
SER A 107
ARG A 175
 None
 0.86A 1urmA-2a4vA:
20.1		 1urmA-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		5 PRO A  74
THR A  76
GLY A  78
LEU A  63
ARG A  82
 None
 1.37A 1urmA-2e67A:
undetectable		 1urmA-2e67A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ers INTERLEUKIN-15
RECEPTOR ALPHA CHAIN

(Homo sapiens) 		no annotation 5 PRO A  89
PRO A  36
SER A  38
LEU A  72
THR A  87
 None
 1.44A 1urmA-2ersA:
undetectable		 1urmA-2ersA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		5 THR A 319
SER A 243
LEU A  75
PHE A 321
ARG A 232
 None
 1.48A 1urmA-2phlA:
undetectable		 1urmA-2phlA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v41 PEROXIREDOXIN 6.

(Arenicola
marina) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 PRO A  38
THR A  42
PRO A  43
SER A  45
ARG A 128
 BEZ  A1222 ( 4.6A)
BEZ  A1222 (-3.6A)
BEZ  A1222 (-3.2A)
BEZ  A1222 (-3.0A)
BEZ  A1222 (-3.3A)
 0.52A 1urmA-2v41A:
17.9		 1urmA-2v41A:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wfc PEROXIREDOXIN 5

(Arenicola
marina) 		PF08534
(Redoxin) 		5 PRO A  67
THR A  71
GLY A  73
SER A  74
LEU A 139
 None
 1.42A 1urmA-2wfcA:
31.0		 1urmA-2wfcA:
61.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wfc PEROXIREDOXIN 5

(Arenicola
marina) 		PF08534
(Redoxin) 		6 PRO A  67
THR A  71
PRO A  72
GLY A  73
SER A  74
ARG A 152
 None
 0.45A 1urmA-2wfcA:
31.0		 1urmA-2wfcA:
61.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wfc PEROXIREDOXIN 5

(Arenicola
marina) 		PF08534
(Redoxin) 		6 THR A  71
PRO A  72
GLY A  73
SER A  74
LEU A 141
ARG A 152
 None
 0.50A 1urmA-2wfcA:
31.0		 1urmA-2wfcA:
61.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		5 PRO A  20
THR A  22
PRO A  23
GLY A  24
ARG A  26
 None
 1.26A 1urmA-3bzmA:
undetectable		 1urmA-3bzmA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drn PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		6 PRO A  38
THR A  42
PRO A  43
GLY A  44
SER A  45
ARG A 112
 CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-2.5A)
CIT  A 500 (-3.7A)
 0.65A 1urmA-3drnA:
18.9		 1urmA-3drnA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		5 THR A 215
GLY A 310
LEU A 281
PHE A 256
THR A 302
 None
None
GOL  A 512 (-4.7A)
None
GOL  A 512 (-4.7A)
 1.33A 1urmA-3ivrA:
undetectable		 1urmA-3ivrA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		5 PRO A  40
THR A  44
PRO A  45
GLY A  46
ARG A 122
 None
 0.64A 1urmA-3ixrA:
18.2		 1urmA-3ixrA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		5 PRO A  40
THR A  44
PRO A  45
GLY A  46
SER A  47
 None
 1.03A 1urmA-3ixrA:
18.2		 1urmA-3ixrA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns4 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 53

(Saccharomyces
cerevisiae) 		PF16854
(VPS53_C) 		5 PRO A 600
GLY A 711
LEU A 762
PHE A 758
ARG A 611
 None
 1.18A 1urmA-3ns4A:
undetectable		 1urmA-3ns4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		5 PRO A 186
PRO A 121
GLY A 122
LEU A 346
PHE A 345
 None
 1.32A 1urmA-3oepA:
undetectable		 1urmA-3oepA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5e TRANSALDOLASE

(Corynebacterium
glutamicum) 		PF00923
(TAL_FSA) 		5 PRO A 141
THR A 143
PRO A 144
GLY A 145
SER A 146
 None
 1.13A 1urmA-3r5eA:
undetectable		 1urmA-3r5eA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 THR A  88
SER A 139
LEU A 232
PHE A  28
ARG A 183
 None
 1.37A 1urmA-3toxA:
2.3		 1urmA-3toxA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af2 THIOL PEROXIDASE

(Escherichia
coli) 		PF08534
(Redoxin) 		5 PRO A  54
THR A  58
SER A  61
LEU A 127
ARG A 133
 None
 0.93A 1urmA-4af2A:
18.7		 1urmA-4af2A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE

(Thermotoga
maritima) 		PF00578
(AhpC-TSA)
PF00881
(Nitroreductase) 		5 PRO A  33
THR A  37
GLY A  39
SER A  40
ARG A 103
 None
SO4  A 402 (-3.4A)
SO4  A 402 (-3.3A)
SO4  A 402 (-3.6A)
SO4  A 402 (-3.5A)
 0.54A 1urmA-4eo3A:
17.4		 1urmA-4eo3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox6 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK

(Synechococcus
elongatus) 		PF00936
(BMC) 		5 PRO A  16
THR A  68
PRO A  69
GLY A  70
LEU A  18
 None
 1.42A 1urmA-4ox6A:
undetectable		 1urmA-4ox6A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 PRO A 112
PRO A 121
SER A 118
LEU A  25
THR A 114
 None
 1.50A 1urmA-4q0mA:
undetectable		 1urmA-4q0mA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 PRO A 279
PRO A 638
GLY A 639
SER A 640
ARG A 188
 None
EDO  A 721 (-4.2A)
None
None
EDO  A 717 (-3.8A)
 0.92A 1urmA-4wd1A:
undetectable		 1urmA-4wd1A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 PRO A 525
PRO A 364
GLY A 365
PHE A 538
THR A 521
 None
None
ONL  A 601 (-3.3A)
None
None
 1.48A 1urmA-4zdkA:
undetectable		 1urmA-4zdkA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enu ALKYL HYDROPEROXIDE
REDUCTASE/ THIOL
SPECIFIC
ANTIOXIDANT/ MAL
ALLERGEN

(Burkholderia
ambifaria) 		PF00578
(AhpC-TSA) 		5 PRO A  37
THR A  41
PRO A  42
GLY A  43
ARG A 119
 None
 0.54A 1urmA-5enuA:
18.5		 1urmA-5enuA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 PRO A  45
THR A  49
PRO A  50
GLY A  51
ARG A 124
 None
 0.68A 1urmA-5epfA:
20.7		 1urmA-5epfA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		5 PRO A 358
GLY A 359
SER A 360
LEU A 349
PHE A 284
 None
 1.47A 1urmA-5fx8A:
undetectable		 1urmA-5fx8A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipg BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xanthomonas
campestris) 		PF00578
(AhpC-TSA) 		5 PRO A  41
THR A  45
PRO A  46
GLY A  47
ARG A 123
 None
 0.87A 1urmA-5ipgA:
17.5		 1urmA-5ipgA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		5 PRO A 151
THR A 177
PRO A 178
GLY A 179
SER A 180
 None
 1.29A 1urmA-5izdA:
2.3		 1urmA-5izdA:
16.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9c PEROXIREDOXIN ASP F3

(Aspergillus
fumigatus) 		PF08534
(Redoxin) 		5 PRO A  54
THR A  58
PRO A  59
SER A  61
ARG A 134
 None
 0.57A 1urmA-5j9cA:
23.6		 1urmA-5j9cA:
33.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus) 		PF08534
(Redoxin) 		5 PRO A  41
THR A  45
PRO A  46
PHE A 117
ARG A 124
 None
 0.90A 1urmA-5k1gA:
27.0		 1urmA-5k1gA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A) 		PF12944
(HAV_VP) 		5 THR A 252
PRO A 140
GLY A 139
SER A 255
LEU A 249
 None
 1.48A 1urmA-5wtfA:
undetectable		 1urmA-5wtfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 5 PRO A 337
THR A 340
GLY A 353
SER A 341
LEU A 332
 None
 1.42A 1urmA-5xgwA:
undetectable		 1urmA-5xgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 5 PRO A  56
THR A  44
SER A 112
LEU A  34
PHE A  93
 None
 1.40A 1urmA-6c29A:
undetectable		 1urmA-6c29A:
undetectable