SIMILAR PATTERNS OF AMINO ACIDS FOR 1UPF_B_URFB999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE


(Gadus morhua)
PF00171
(Aldedh)
5 ALA A 164
TYR A 167
ILE A 171
ASP A 118
PHE A 169
None
1.42A 1upfB-1a4sA:
undetectable
1upfB-1a4sA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)


(Escherichia
coli)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
4 ALA A 253
TYR A 255
ILE A 256
ILE A   5
None
0.91A 1upfB-1b0aA:
4.5
1upfB-1b0aA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 MET 1 144
ALA 1 142
ILE 1 141
ASP 1 104
PHE 1 107
None
1.49A 1upfB-1gt91:
undetectable
1upfB-1gt91:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 ALA A 106
ILE A 109
ILE A  72
ASP A  74
None
0.92A 1upfB-1h74A:
undetectable
1upfB-1h74A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1


(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 MET A 244
ALA A 240
ILE A 203
ILE A 201
None
0.86A 1upfB-1hjvA:
undetectable
1upfB-1hjvA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE


([Bacillus]
caldolyticus)
PF14681
(UPRTase)
4 ALA A 135
TYR A 193
ILE A 194
ASP A 200
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
U5P  A 250 (-4.4A)
0.35A 1upfB-1i5eA:
27.7
1upfB-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE


([Bacillus]
caldolyticus)
PF14681
(UPRTase)
4 MET A 133
ALA A 135
TYR A 193
ILE A 194
U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
0.59A 1upfB-1i5eA:
27.7
1upfB-1i5eA:
36.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB


(Thermotoga
maritima)
PF05491
(RuvB_C)
PF05496
(RuvB_N)
4 ALA A 209
ILE A 189
ILE A 200
ASP A 202
None
0.77A 1upfB-1in8A:
undetectable
1upfB-1in8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E


(Chondrostereum
purpureum)
PF00295
(Glyco_hydro_28)
5 ALA A 159
ILE A 184
ILE A 176
ASP A 156
PHE A 155
None
1.45A 1upfB-1k5cA:
undetectable
1upfB-1k5cA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE


(Salmonella
enterica)
PF00155
(Aminotran_1_2)
4 ALA A 114
TYR A 111
ILE A 183
ASP A 185
None
0.91A 1upfB-1lc7A:
3.3
1upfB-1lc7A:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermotoga
maritima)
PF14681
(UPRTase)
5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
U5P  A 600 (-4.0A)
0.55A 1upfB-1o5oA:
27.5
1upfB-1o5oA:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Bacillus
subtilis)
PF01070
(FMN_dh)
4 MET A 254
ALA A 256
ILE A 208
ILE A 245
None
0.91A 1upfB-1p0nA:
undetectable
1upfB-1p0nA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110


(Staphylococcus
aureus)
PF03180
(Lipoprotein_9)
4 TYR A 252
ILE A 255
ILE A  43
ASP A  88
None
0.82A 1upfB-1p99A:
undetectable
1upfB-1p99A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE


(Candida
albicans)
PF01238
(PMI_typeI)
4 ALA A 163
ILE A 181
ILE A 184
ASP A 156
None
0.85A 1upfB-1pmiA:
undetectable
1upfB-1pmiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)


(Homo sapiens)
PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N)
4 ALA A 168
ILE A 171
ILE A 210
PHE A 207
None
0.88A 1upfB-1r5lA:
undetectable
1upfB-1r5lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA


(Mannheimia
haemolytica)
PF13343
(SBP_bac_6)
4 ALA A 298
ILE A  60
ILE A 231
PHE A  88
None
0.92A 1upfB-1si1A:
undetectable
1upfB-1si1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32)
PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ)
5 MET A 333
ALA A 331
ILE A 330
ASP A 293
PHE A 296
None
1.33A 1upfB-1t1eA:
undetectable
1upfB-1t1eA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 ALA A 131
TYR A 128
ILE A 108
ILE A 200
ASP A 202
None
None
None
None
PLP  A 400 (-2.9A)
1.33A 1upfB-1u08A:
4.1
1upfB-1u08A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens)
PF08623
(TIP120)
4 MET C 158
ALA C 154
ILE C 142
ILE C 176
None
0.66A 1upfB-1u6gC:
undetectable
1upfB-1u6gC:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii)
PF01351
(RNase_HII)
4 ALA A   4
ILE A 140
ILE A  30
ASP A  26
None
0.94A 1upfB-1uaxA:
undetectable
1upfB-1uaxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiz MACROPHAGE MIGRATION
INHIBITORY FACTOR


(Xenopus laevis)
PF01187
(MIF)
4 ALA A  27
ILE A  37
ILE A  39
ASP A  21
None
0.92A 1upfB-1uizA:
undetectable
1upfB-1uizA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermus
thermophilus)
PF14681
(UPRTase)
5 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
None
SO4  A 517 (-3.3A)
None
None
SO4  A 514 ( 4.4A)
0.52A 1upfB-1v9sA:
26.8
1upfB-1v9sA:
37.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2


(Infectious
bursal disease
virus)
PF01766
(Birna_VP2)
5 ALA J 232
TYR J 206
ILE J 308
ILE J 305
ASP J 235
None
1.15A 1upfB-1wcdJ:
undetectable
1upfB-1wcdJ:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Sulfolobus
solfataricus)
PF14681
(UPRTase)
5 MET A 142
ALA A 144
TYR A 202
ILE A 203
ASP A 209
U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
U5P  A1250 (-4.1A)
0.55A 1upfB-1xttA:
24.2
1upfB-1xttA:
34.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 ALA A 104
TYR A 117
ILE A 110
PHE A  99
None
None
None
NAP  A 900 ( 4.9A)
0.90A 1upfB-1ys4A:
2.2
1upfB-1ys4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris)
PF02915
(Rubrerythrin)
4 ALA A 112
TYR A 160
ILE A  62
ASP A 105
None
0.89A 1upfB-1yuzA:
undetectable
1upfB-1yuzA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq7 HYPOTHETICAL PROTEIN
MM0484


(Methanosarcina
mazei)
PF01871
(AMMECR1)
4 ALA A  14
ILE A  74
ILE A 105
PHE A 185
None
0.78A 1upfB-1zq7A:
undetectable
1upfB-1zq7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B


(Bacillus
subtilis)
PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB)
5 ALA A  70
TYR A  74
ILE A 139
ILE A 138
PHE A  89
None
1.31A 1upfB-2d7dA:
2.9
1upfB-2d7dA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN


(Pyrococcus
horikoshii)
PF00574
(CLP_protease)
4 TYR A  25
ILE A  56
ILE A  82
ASP A  51
None
0.85A 1upfB-2deoA:
undetectable
1upfB-2deoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
4 ALA A 127
TYR A 124
ILE A 195
ASP A 197
None
EPE  A 501 (-4.9A)
None
EPE  A 501 (-3.5A)
0.78A 1upfB-2douA:
3.9
1upfB-2douA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 ALA A 153
ILE A 160
ILE A 162
PHE A 186
None
0.81A 1upfB-2dzdA:
undetectable
1upfB-2dzdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus)
PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C)
4 MET A  78
ALA A  82
ILE A  83
ILE A 105
None
0.92A 1upfB-2e28A:
undetectable
1upfB-2e28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2d METALLOPROTEINASE
INHIBITOR 2


(Bos taurus)
PF00965
(TIMP)
5 MET C1096
ALA C1090
ILE C1017
ILE C1086
ASP C1102
None
1.20A 1upfB-2e2dC:
undetectable
1upfB-2e2dC:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Aquifex
aeolicus)
PF14681
(UPRTase)
4 MET A 130
ALA A 132
TYR A 190
ILE A 191
None
SO4  A1301 (-3.1A)
None
None
0.88A 1upfB-2e55A:
25.8
1upfB-2e55A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE


(Geobacillus
kaustophilus)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
4 ALA A  70
ILE A  69
ILE A  29
PHE A  58
None
0.93A 1upfB-2eggA:
4.1
1upfB-2eggA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Escherichia
coli)
PF14681
(UPRTase)
5 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
None
SO4  A 210 (-3.5A)
None
None
None
0.81A 1upfB-2ehjA:
26.9
1upfB-2ehjA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7


(Homo sapiens)
PF00069
(Pkinase)
4 MET A 632
ILE A 569
ILE A 574
ASP A 572
None
None
None
TRS  A 801 ( 4.9A)
0.84A 1upfB-2f57A:
undetectable
1upfB-2f57A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP


(Zoanthus sp.)
PF01353
(GFP)
4 ALA A 223
TYR A  75
ILE A 224
PHE A 199
None
0.91A 1upfB-2fl1A:
undetectable
1upfB-2fl1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Staphylococcus
aureus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 MET A 232
ALA A  52
ILE A 196
PHE A 204
None
0.92A 1upfB-2gqdA:
undetectable
1upfB-2gqdA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh8 HYPOTHETICAL PROTEIN
YDFO


(Escherichia
coli)
PF07166
(DUF1398)
4 ILE A  11
ILE A  15
ASP A  17
PHE A  16
None
0.91A 1upfB-2hh8A:
undetectable
1upfB-2hh8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae)
PF00481
(PP2C)
4 MET A 570
ALA A 572
ILE A 520
ASP A 553
None
0.83A 1upfB-2i0oA:
undetectable
1upfB-2i0oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2


(Homo sapiens)
PF00248
(Aldo_ket_red)
4 ALA A 245
ILE A 255
ILE A 296
ASP A 238
None
0.92A 1upfB-2ipjA:
undetectable
1upfB-2ipjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae)
PF00005
(ABC_tran)
5 ALA A1474
TYR A1493
ILE A1475
ILE A1593
ASP A1567
None
1.37A 1upfB-2ix8A:
undetectable
1upfB-2ix8A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixf ANTIGEN PEPTIDE
TRANSPORTER 1


(Rattus
norvegicus)
PF00005
(ABC_tran)
5 ALA A 577
ILE A 589
ILE A 602
ASP A 610
PHE A 572
GOL  A   3 (-3.2A)
GOL  A   3 ( 4.8A)
None
None
None
1.42A 1upfB-2ixfA:
undetectable
1upfB-2ixfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3


(Brevibacillus
brevis)
PF00550
(PP-binding)
PF00668
(Condensation)
5 ALA A 421
ILE A 286
ILE A 353
ASP A 431
PHE A 430
None
1.01A 1upfB-2jgpA:
undetectable
1upfB-2jgpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli)
PF00781
(DAGK_cat)
4 ALA A  96
ILE A  70
ASP A 269
PHE A  99
None
0.94A 1upfB-2jgrA:
undetectable
1upfB-2jgrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9d UNCHARACTERIZED
PROTEIN


(Methylobacillus
flagellatus)
PF12112
(DUF3579)
4 MET A  82
ALA A  85
ILE A  15
ILE A  13
None
0.92A 1upfB-2l9dA:
undetectable
1upfB-2l9dA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF08712
(Nfu_N)
4 ALA A 110
ILE A  17
ILE A  19
ASP A 103
None
0.93A 1upfB-2ltlA:
undetectable
1upfB-2ltlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogr FLUORESCENT PROTEIN
FP538


(Zoanthus sp.)
PF01353
(GFP)
4 ALA A 223
TYR A  75
ILE A 224
PHE A 199
None
0.92A 1upfB-2ogrA:
undetectable
1upfB-2ogrA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE


(Trichormus
variabilis)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
4 ALA A  95
TYR A  90
ILE A  86
ILE A  25
COA  A 500 (-3.9A)
None
COA  A 500 (-3.9A)
None
0.75A 1upfB-2ozgA:
undetectable
1upfB-2ozgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB


(Nitrosomonas
europaea)
PF01272
(GreA_GreB)
PF14760
(Rnk_N)
4 ALA A  14
ILE A   9
ILE A  50
ASP A  46
None
0.88A 1upfB-2pn0A:
undetectable
1upfB-2pn0A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506


(Zoanthus sp.)
PF01353
(GFP)
4 ALA A 223
TYR A  75
ILE A 224
PHE A 199
None
0.92A 1upfB-2pxsA:
undetectable
1upfB-2pxsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
4 ALA A 227
ILE A 226
ILE A 238
ASP A 221
None
0.86A 1upfB-2v7gA:
undetectable
1upfB-2v7gA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A


(Deinococcus
radiodurans)
PF00005
(ABC_tran)
4 ALA A 710
ILE A 707
ASP A 610
PHE A 609
None
0.91A 1upfB-2vf8A:
undetectable
1upfB-2vf8A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri)
PF07201
(HrpJ)
4 TYR A 114
ILE A  90
ASP A  92
PHE A  91
None
0.93A 1upfB-2vj5A:
undetectable
1upfB-2vj5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN


(Methylococcus
capsulatus)
no annotation 4 TYR A  94
ILE A 331
ILE A 333
PHE A 139
None
0.82A 1upfB-2vowA:
undetectable
1upfB-2vowA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID


(Neisseria
gonorrhoeae)
PF00497
(SBP_bac_3)
4 MET A 254
ALA A 252
ILE A 251
ASP A  84
None
0.88A 1upfB-2yjpA:
undetectable
1upfB-2yjpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE


(Pseudomonas sp.
P-501)
no annotation 4 ALA A 123
ILE A 136
ILE A 520
ASP A 134
None
0.89A 1upfB-2yr5A:
undetectable
1upfB-2yr5A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu4 E3 SUMO-PROTEIN
LIGASE NSE2


(Homo sapiens)
PF11789
(zf-Nse)
4 MET A  38
ALA A  34
ILE A  35
ILE A  61
None
0.86A 1upfB-2yu4A:
undetectable
1upfB-2yu4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN


(Pyrococcus
horikoshii)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
4 ALA A  97
TYR A 140
ILE A 137
ILE A  71
None
0.92A 1upfB-2yxlA:
undetectable
1upfB-2yxlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN


(Thermotoga
maritima)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
4 MET A 198
ALA A 201
ILE A 204
ASP A 219
None
0.83A 1upfB-2yyzA:
undetectable
1upfB-2yyzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN


(Streptomyces
coelicolor)
PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N)
4 ALA A 194
TYR A 186
ILE A 184
ILE A 135
None
0.91A 1upfB-2zdsA:
undetectable
1upfB-2zdsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT


(Thermococcus
kodakarensis)
PF01008
(IF-2B)
4 ALA A 209
ILE A 251
ASP A 280
PHE A 279
None
0.80A 1upfB-3a9cA:
3.6
1upfB-3a9cA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 ALA A 586
TYR A 584
ILE A 635
ASP A 376
None
0.80A 1upfB-3aqpA:
undetectable
1upfB-3aqpA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs4 UNCHARACTERIZED
PROTEIN PH0321


(Pyrococcus
horikoshii)
no annotation 4 MET A  53
ALA A 144
ILE A 145
ILE A  63
None
0.92A 1upfB-3bs4A:
2.2
1upfB-3bs4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE


(Methanococcus
maripaludis)
PF08241
(Methyltransf_11)
4 TYR A 197
ILE A 210
ILE A 208
PHE A 185
None
0.77A 1upfB-3dlcA:
undetectable
1upfB-3dlcA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Burkholderia
pseudomallei)
PF14681
(UPRTase)
5 MET A 137
ALA A 139
TYR A 199
ILE A 200
ASP A 206
None
0.54A 1upfB-3dmpA:
25.9
1upfB-3dmpA:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II


(Bartonella
henselae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 MET A 239
ALA A  49
ILE A 201
PHE A 209
None
0.93A 1upfB-3e60A:
undetectable
1upfB-3e60A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria)
PF01353
(GFP)
4 ALA A 268
TYR A 250
ILE A 251
ILE A 101
None
0.90A 1upfB-3evpA:
undetectable
1upfB-3evpA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezs AMINOTRANSFERASE
ASPB


(Helicobacter
pylori)
PF00155
(Aminotran_1_2)
4 ALA A 123
TYR A 120
ILE A 190
ASP A 192
None
None
None
EDO  A 379 (-3.2A)
0.91A 1upfB-3ezsA:
3.3
1upfB-3ezsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE


(Ruegeria sp.
TM1040)
PF00202
(Aminotran_3)
4 ALA A 221
TYR A 133
ILE A 130
ILE A 283
None
0.93A 1upfB-3fcrA:
3.3
1upfB-3fcrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens)
PF02645
(DegV)
4 MET A   1
ILE A 130
ILE A 139
PHE A 136
None
0.84A 1upfB-3fdjA:
undetectable
1upfB-3fdjA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE


(Homo sapiens;
Saccharomyces
cerevisiae)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
4 ALA A 301
ILE A 292
ASP A 257
PHE A 256
None
0.85A 1upfB-3fjoA:
2.3
1upfB-3fjoA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Clostridium
acetobutylicum)
PF00155
(Aminotran_1_2)
4 TYR A 111
ILE A  95
ILE A 181
ASP A 183
None
0.92A 1upfB-3ftbA:
3.4
1upfB-3ftbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE


(Burkholderia
pseudomallei)
PF13561
(adh_short_C2)
4 MET A 128
ALA A 126
ILE A 125
ILE A 136
None
0.83A 1upfB-3gk3A:
3.2
1upfB-3gk3A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1


(Mycobacterium
tuberculosis)
PF00464
(SHMT)
4 ALA A 105
TYR A 243
ILE A 247
ASP A 219
None
0.93A 1upfB-3h7fA:
3.5
1upfB-3h7fA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE


(Salmonella
enterica)
PF02614
(UxaC)
4 MET A 147
ILE A 179
ILE A  41
ASP A  44
None
0.87A 1upfB-3iacA:
undetectable
1upfB-3iacA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4


(Mus musculus)
no annotation 4 ALA K 784
TYR K 810
ILE K 811
ILE K 804
None
0.76A 1upfB-3jblK:
undetectable
1upfB-3jblK:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2


(Homo sapiens)
PF01401
(Peptidase_M2)
4 ALA A 533
ILE A 544
ILE A 407
PHE A 525
None
0.94A 1upfB-3kbhA:
undetectable
1upfB-3kbhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5


(Homo sapiens)
PF00069
(Pkinase)
4 ALA A 717
ILE A 637
ILE A 641
PHE A 722
None
0.90A 1upfB-3kn5A:
undetectable
1upfB-3kn5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Agrobacterium
fabrum)
PF03009
(GDPD)
5 ALA A 202
ILE A 173
ILE A 184
ASP A 205
PHE A 206
None
None
None
ACT  A 254 (-3.7A)
None
1.37A 1upfB-3ks5A:
undetectable
1upfB-3ks5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
mutans)
PF00117
(GATase)
5 ALA A 153
TYR A 174
ILE A 167
ILE A 166
ASP A 127
None
1.49A 1upfB-3l7nA:
undetectable
1upfB-3l7nA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9k RE64145P

(Drosophila
melanogaster)
PF03259
(Robl_LC7)
4 MET A  47
ALA A  44
ILE A  90
ILE A  79
None
0.93A 1upfB-3l9kA:
undetectable
1upfB-3l9kA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776


(Streptococcus
mutans)
PF10672
(Methyltrans_SAM)
4 ALA A 211
ILE A 288
ILE A 290
PHE A 226
None
None
None
SAH  A 401 (-4.1A)
0.92A 1upfB-3ldfA:
2.9
1upfB-3ldfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwz 3-DEHYDROQUINATE
DEHYDRATASE


(Yersinia pestis)
PF01220
(DHquinase_II)
4 ALA A 142
ILE A 100
ILE A 127
PHE A 137
None
0.89A 1upfB-3lwzA:
3.2
1upfB-3lwzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nec INFLAMMATORY
PROFILIN


(Toxoplasma
gondii)
PF00235
(Profilin)
5 ALA A  26
ILE A 131
ILE A 124
ASP A 110
PHE A 109
None
1.23A 1upfB-3necA:
undetectable
1upfB-3necA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM


(Rhodopseudomonas
palustris)
no annotation 4 MET B 324
ALA B 322
ILE B 321
ILE B 109
None
0.91A 1upfB-3nndB:
undetectable
1upfB-3nndB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5y SENSOR PROTEIN

(Bacillus
halodurans)
PF13492
(GAF_3)
4 ALA A 142
TYR A 107
ILE A 106
ILE A 104
None
0.68A 1upfB-3o5yA:
undetectable
1upfB-3o5yA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1


(Vibrio cholerae)
PF01048
(PNP_UDP_1)
4 MET A 238
ALA A 242
ILE A 213
PHE A 235
None
0.93A 1upfB-3of3A:
undetectable
1upfB-3of3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oov METHYL-ACCEPTING
CHEMOTAXIS PROTEIN,
PUTATIVE


(Geobacter
sulfurreducens)
PF13185
(GAF_2)
4 TYR A  83
ILE A 114
ASP A  79
PHE A  77
None
0.85A 1upfB-3oovA:
undetectable
1upfB-3oovA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria;
Escherichia
coli)
PF01353
(GFP)
PF01547
(SBP_bac_1)
4 ALA A 522
TYR A 504
ILE A 505
ILE A 355
None
0.92A 1upfB-3osrA:
undetectable
1upfB-3osrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis)
PF12741
(SusD-like)
4 ALA A 241
ILE A 179
ILE A 131
PHE A 209
None
0.79A 1upfB-3p1uA:
undetectable
1upfB-3p1uA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8b TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG


(Pyrococcus
furiosus)
PF00467
(KOW)
PF03439
(Spt5-NGN)
4 ALA B  19
TYR B  23
ILE B  22
ILE B  33
None
0.90A 1upfB-3p8bB:
undetectable
1upfB-3p8bB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE


(Homo sapiens)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 ALA A 324
ILE A 315
ASP A 280
PHE A 279
None
0.89A 1upfB-3qfsA:
undetectable
1upfB-3qfsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE


(Coxiella
burnetii)
PF01041
(DegT_DnrJ_EryC1)
4 ALA A 145
ILE A 126
ILE A 110
ASP A 137
None
None
None
NA  A 373 (-4.8A)
0.88A 1upfB-3uwcA:
3.8
1upfB-3uwcA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx4 PUTATIVE ABC
TRANSPORTER,
ATP-BINDING PROTEIN
COMA


(Streptococcus
mutans)
PF00005
(ABC_tran)
4 TYR A 606
ILE A 574
ILE A 716
ASP A 689
None
None
None
MG  A 802 ( 3.9A)
0.83A 1upfB-3vx4A:
undetectable
1upfB-3vx4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyv HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 MET B 115
ALA B 111
ILE B   6
ILE B  10
None
0.93A 1upfB-4cyvB:
undetectable
1upfB-4cyvB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eun THERMORESISTANT
GLUCOKINASE


(Janibacter sp.
HTCC2649)
PF01202
(SKI)
4 MET A  49
ALA A  47
ILE A  46
ASP A  59
None
0.87A 1upfB-4eunA:
undetectable
1upfB-4eunA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqv HEMAGGLUTININ HA2

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 MET B 115
ALA B 111
ILE B   6
ILE B  10
None
0.91A 1upfB-4fqvB:
undetectable
1upfB-4fqvB:
20.68