SIMILAR PATTERNS OF AMINO ACIDS FOR 1UOB_A_PNNA1311_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b8k | PROTEIN(NEUROTROPHIN-3) (Homo sapiens) |
PF00243(NGF) | 3 | ARG A 100ARG A 31ILE A 28 | None | 0.76A | 1uobA-1b8kA:0.0 | 1uobA-1b8kA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fiu | TYPE II RESTRICTIONENZYME NGOMI (Neisseriagonorrhoeae) |
PF09015(NgoMIV_restric) | 3 | ARG A 191ARG A 194ILE A 231 | None | 0.76A | 1uobA-1fiuA:0.0 | 1uobA-1fiuA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fnf | FIBRONECTIN (Homo sapiens) |
PF00041(fn3) | 3 | ARG A1358ARG A1360ILE A1410 | None | 0.74A | 1uobA-1fnfA:0.0 | 1uobA-1fnfA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iir | GLYCOSYLTRANSFERASEGTFB (Amycolatopsisorientalis) |
PF03033(Glyco_transf_28) | 3 | ARG A 2ARG A 32ILE A 118 | None | 0.72A | 1uobA-1iirA:0.0 | 1uobA-1iirA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2b | ARCHAEOSINETRNA-GUANINETRANSGLYCOSYLASE (Pyrococcushorikoshii) |
PF01472(PUA)PF01702(TGT)PF14809(TGT_C1)PF14810(TGT_C2) | 3 | ARG A 207ARG A 348ILE A 212 | G D 938 ( 4.4A)NoneNone | 0.80A | 1uobA-1j2bA:0.0 | 1uobA-1j2bA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1miv | TRNA CCA-ADDINGENZYME (Geobacillusstearothermophilus) |
PF01743(PolyA_pol)PF12627(PolyA_pol_RNAbd)PF13735(tRNA_NucTran2_2) | 3 | ARG A 160ARG A 163ILE A 141 | None | 0.79A | 1uobA-1mivA:0.0 | 1uobA-1mivA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o4z | BETA-AGARASE B (Zobelliagalactanivorans) |
PF00722(Glyco_hydro_16) | 3 | ARG A 246ARG A 346ILE A 187 | NA A1007 (-4.1A)NoneNone | 0.77A | 1uobA-1o4zA:1.5 | 1uobA-1o4zA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5w | AMINE OXIDASE[FLAVIN-CONTAINING]A (Rattusnorvegicus) |
PF01593(Amino_oxidase) | 3 | ARG A 45ARG A 47ILE A 23 | FAD A 652 (-4.3A)NoneFAD A 652 (-4.8A) | 0.66A | 1uobA-1o5wA:0.0 | 1uobA-1o5wA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qpo | QUINOLINATE ACIDPHOSPHORIBOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 3 | ARG A 235ARG A 239ILE A 219 | None | 0.67A | 1uobA-1qpoA:0.0 | 1uobA-1qpoA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP1) (Rhinovirus A) |
PF00073(Rhv) | 3 | ARG 1 223ARG 1 158ILE 1 235 | None | 0.62A | 1uobA-1r1a1:undetectable | 1uobA-1r1a1:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t4b | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Escherichiacoli) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | ARG A 361ARG A 360ILE A 95 | None | 0.64A | 1uobA-1t4bA:undetectable | 1uobA-1t4bA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpr | LUCIFERASE (Lingulodiniumpolyedra) |
PF10284(Luciferase_3H)PF10285(Luciferase_cat) | 3 | ARG A1124ARG A1143ILE A1163 | None | 0.80A | 1uobA-1vprA:undetectable | 1uobA-1vprA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xny | PROPIONYL-COACARBOXYLASE COMPLEXB SUBUNIT (Streptomycescoelicolor) |
PF01039(Carboxyl_trans) | 3 | ARG A 393ARG A 392ILE A 528 | None | 0.77A | 1uobA-1xnyA:undetectable | 1uobA-1xnyA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwi | SKD1 PROTEIN (Homo sapiens) |
PF00004(AAA)PF09336(Vps4_C) | 3 | ARG A 289ARG A 295ILE A 236 | None | 0.75A | 1uobA-1xwiA:undetectable | 1uobA-1xwiA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8p | [PYRUVATEDEHYDROGENASE[LIPOAMIDE]] KINASEISOZYME 3 (Homo sapiens) |
PF02518(HATPase_c)PF10436(BCDHK_Adom3) | 3 | ARG A 336ARG A 368ILE A 159 | None | 0.81A | 1uobA-1y8pA:undetectable | 1uobA-1y8pA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 3 | ARG X 603ARG X 600ILE X 612 | SO4 X 902 ( 2.9A)SO4 X 902 (-2.8A)None | 0.64A | 1uobA-1z3iX:undetectable | 1uobA-1z3iX:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z8l | GLUTAMATECARBOXYPEPTIDASE II (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 3 | ARG A 363ARG A 411ILE A 416 | None | 0.78A | 1uobA-1z8lA:undetectable | 1uobA-1z8lA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zk7 | MERCURIC REDUCTASE (Pseudomonasaeruginosa) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | ARG A 128ARG A 118ILE A 33 | None | 0.67A | 1uobA-1zk7A:undetectable | 1uobA-1zk7A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cx9 | ACYL-COADEHYDROGENASE (Thermusthermophilus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 3 | ARG A 73ARG A 69ILE A 250 | None | 0.78A | 1uobA-2cx9A:undetectable | 1uobA-2cx9A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dvm | 439AA LONGHYPOTHETICAL MALATEOXIDOREDUCTASE (Pyrococcushorikoshii) |
PF00390(malic)PF03949(Malic_M) | 3 | ARG A 386ARG A 383ILE A 412 | None | 0.82A | 1uobA-2dvmA:undetectable | 1uobA-2dvmA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw4 | LYSINE-SPECIFICHISTONE DEMETHYLASE1 (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 3 | ARG A 310ARG A 312ILE A 584 | FAD A1001 (-4.4A)NoneNone | 0.76A | 1uobA-2dw4A:undetectable | 1uobA-2dw4A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eij | CYTOCHROME C OXIDASESUBUNIT 1 (Bos taurus) |
PF00115(COX1) | 3 | ARG A 439ARG A 438ILE A 37 | HEA A 515 (-3.8A)HEA A 516 ( 3.1A)HEA A 515 (-4.2A) | 0.79A | 1uobA-2eijA:undetectable | 1uobA-2eijA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8o | GERANYLTRANSTRANSFERASE (Agrobacteriumfabrum) |
PF00348(polyprenyl_synt) | 3 | ARG A 227ARG A 248ILE A 235 | None | 0.64A | 1uobA-2h8oA:undetectable | 1uobA-2h8oA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ip2 | PROBABLEPHENAZINE-SPECIFICMETHYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 3 | ARG A 218ARG A 193ILE A 185 | None | 0.80A | 1uobA-2ip2A:undetectable | 1uobA-2ip2A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jb1 | L-AMINO ACID OXIDASE (Rhodococcusopacus) |
PF01593(Amino_oxidase) | 3 | ARG A 44ARG A 46ILE A 255 | FAD A1489 (-3.9A)NoneNone | 0.80A | 1uobA-2jb1A:undetectable | 1uobA-2jb1A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqh | COMPLEMENT COMPONENTC8 ALPHA CHAIN (Homo sapiens) |
PF01823(MACPF) | 3 | ARG A 454ARG A 450ILE A 434 | None | 0.79A | 1uobA-2qqhA:undetectable | 1uobA-2qqhA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASEPOLYPEPTIDE I+III (Thermusthermophilus) |
PF00115(COX1)PF00510(COX3) | 3 | ARG A 448ARG A 447ILE A 49 | HAS A1015 (-3.9A)HAS A1016 ( 3.1A)HAS A1015 (-4.1A) | 0.78A | 1uobA-2yevA:undetectable | 1uobA-2yevA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ztg | ALANYL-TRNASYNTHETASE (Archaeoglobusfulgidus) |
PF01411(tRNA-synt_2c)PF07973(tRNA_SAD) | 3 | ARG A 418ARG A 367ILE A 411 | None | 0.82A | 1uobA-2ztgA:undetectable | 1uobA-2ztgA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiz | DNA POLYMERASESLIDING CLAMP B (Sulfurisphaeratokodaii) |
PF00705(PCNA_N)PF02747(PCNA_C) | 3 | ARG A 110ARG A 103ILE A 78 | SO4 A 249 ( 4.6A)SO4 A 249 (-3.2A)None | 0.76A | 1uobA-3aizA:undetectable | 1uobA-3aizA:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axy | 14-3-3-LIKE PROTEINGF14-C (Oryza sativa) |
PF00244(14-3-3) | 3 | ARG C 58ARG C 62ILE C 90 | None | 0.82A | 1uobA-3axyC:undetectable | 1uobA-3axyC:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ay3 | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Chromohalobactersalexigens) |
PF01370(Epimerase) | 3 | ARG A 4ARG A 30ILE A 67 | None | 0.64A | 1uobA-3ay3A:undetectable | 1uobA-3ay3A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5o | UPF0311 PROTEINRPA1785 (Rhodopseudomonaspalustris) |
PF11578(DUF3237) | 3 | ARG A 140ARG A 90ILE A 147 | None | 0.54A | 1uobA-3c5oA:undetectable | 1uobA-3c5oA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ca9 | DEOXYURIDINETRIPHOSPHATASE (ParameciumbursariaChlorella virusIL3A) |
PF00692(dUTPase) | 3 | ARG A 106ARG A 63ILE A 101 | None | 0.74A | 1uobA-3ca9A:undetectable | 1uobA-3ca9A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmp | URACILPHOSPHORIBOSYLTRANSFERASE (Burkholderiapseudomallei) |
PF14681(UPRTase) | 3 | ARG A 102ARG A 129ILE A 98 | None | 0.69A | 1uobA-3dmpA:undetectable | 1uobA-3dmpA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e20 | EUKARYOTIC PEPTIDECHAIN RELEASE FACTORSUBUNIT 1 (Schizosaccharomycespombe) |
no annotation | 3 | ARG C 16ARG C 15ILE C 22 | None | 0.62A | 1uobA-3e20C:undetectable | 1uobA-3e20C:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fgb | UNCHARACTERIZEDPROTEIN Q89ZH8_BACTN (Bacteroidesthetaiotaomicron) |
PF10282(Lactonase) | 3 | ARG A 331ARG A 300ILE A 250 | None | 0.81A | 1uobA-3fgbA:undetectable | 1uobA-3fgbA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gaa | UNCHARACTERIZEDPROTEIN TA1441 (Thermoplasmaacidophilum) |
PF09754(PAC2) | 3 | ARG A 76ARG A 80ILE A 64 | None | 0.71A | 1uobA-3gaaA:undetectable | 1uobA-3gaaA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in5 | DNA POLYMERASE KAPPA (Homo sapiens) |
PF00817(IMS)PF11798(IMS_HHH)PF11799(IMS_C) | 3 | ARG A 339ARG A 97ILE A 335 | None | 0.69A | 1uobA-3in5A:undetectable | 1uobA-3in5A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j3i | CAPSID PROTEIN (Penicilliumchrysogenumvirus) |
no annotation | 3 | ARG A 800ARG A 862ILE A 855 | None | 0.82A | 1uobA-3j3iA:undetectable | 1uobA-3j3iA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4w | UNCHARACTERIZEDPROTEIN BB4693 (Bordetellabronchiseptica) |
PF04909(Amidohydro_2) | 3 | ARG A 203ARG A 204ILE A 197 | None | 0.74A | 1uobA-3k4wA:undetectable | 1uobA-3k4wA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myv | SUSD SUPERFAMILYPROTEIN (Bacteroidesvulgatus) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | ARG A 224ARG A 152ILE A 193 | EDO A 516 (-3.0A)EDO A 516 (-3.8A)None | 0.78A | 1uobA-3myvA:undetectable | 1uobA-3myvA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p48 | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Saccharomycescerevisiae) |
PF00692(dUTPase) | 3 | ARG A 111ARG A 68ILE A 106 | NoneDUP A 148 (-3.8A)None | 0.79A | 1uobA-3p48A:undetectable | 1uobA-3p48A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzr | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Vibrio cholerae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | ARG A 361ARG A 360ILE A 94 | None | 0.70A | 1uobA-3pzrA:undetectable | 1uobA-3pzrA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc3 | ATP-DEPENDENT RNAHELICASE SUPV3L1,MITOCHONDRIAL (Homo sapiens) |
PF00271(Helicase_C)PF12513(SUV3_C) | 3 | ARG A 473ARG A 470ILE A 351 | ANP A 801 (-3.0A)ANP A 801 (-3.0A)None | 0.82A | 1uobA-3rc3A:undetectable | 1uobA-3rc3A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rft | URONATEDEHYDROGENASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 3 | ARG A 5ARG A 31ILE A 68 | SO4 A 268 (-3.0A)NoneNone | 0.81A | 1uobA-3rftA:undetectable | 1uobA-3rftA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6p | CAPSID PROTEIN (Helicoverpaarmigera stuntvirus) |
PF03566(Peptidase_A21) | 3 | ARG A 217ARG A 219ILE A 157 | None | 0.69A | 1uobA-3s6pA:undetectable | 1uobA-3s6pA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sz6 | CONSERVED DOMAINPROTEIN (Bacillusanthracis) |
PF05031(NEAT) | 3 | ARG A 54ARG A 57ILE A 131 | None | 0.75A | 1uobA-3sz6A:undetectable | 1uobA-3sz6A:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw3 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Burkholderiathailandensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | ARG A 365ARG A 364ILE A 94 | EDO A 374 (-3.9A)EDO A 374 (-4.3A)None | 0.64A | 1uobA-3uw3A:undetectable | 1uobA-3uw3A:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vdd | PROTEIN VP1 (Rhinovirus A) |
PF00073(Rhv) | 3 | ARG A 219ARG A 156ILE A 139 | None | 0.77A | 1uobA-3vddA:undetectable | 1uobA-3vddA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vdd | PROTEIN VP1 (Rhinovirus A) |
PF00073(Rhv) | 3 | ARG A 219ARG A 156ILE A 231 | None | 0.82A | 1uobA-3vddA:undetectable | 1uobA-3vddA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 3 | ARG A 576ARG A 471ILE A 525 | None | 0.70A | 1uobA-3wxoA:undetectable | 1uobA-3wxoA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zf4 | DUTPASE (Staphylococcusvirus 80alpha) |
PF00692(dUTPase) | 3 | ARG A 134ARG A 64ILE A 129 | None | 0.72A | 1uobA-3zf4A:undetectable | 1uobA-3zf4A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxs | CRYPTOCHROME B (Rhodobactersphaeroides) |
PF04244(DPRP) | 3 | ARG A 89ARG A 90ILE A 83 | None | 0.70A | 1uobA-3zxsA:undetectable | 1uobA-3zxsA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atf | BETA-AGARASE B (Zobelliagalactanivorans) |
PF00722(Glyco_hydro_16) | 3 | ARG A 246ARG A 346ILE A 187 | None | 0.67A | 1uobA-4atfA:undetectable | 1uobA-4atfA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bk1 | PROBABLE SALICYLATEMONOOXYGENASE (Rhodococcusjostii) |
PF01494(FAD_binding_3) | 3 | ARG A 110ARG A 187ILE A 215 | FAD A1398 (-2.6A)FAD A1398 (-3.6A)P3A A1399 (-4.4A) | 0.79A | 1uobA-4bk1A:undetectable | 1uobA-4bk1A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exb | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00248(Aldo_ket_red) | 3 | ARG A 119ARG A 123ILE A 129 | None | 0.73A | 1uobA-4exbA:undetectable | 1uobA-4exbA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk6 | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Mycobacteroidesabscessus) |
PF00692(dUTPase) | 3 | ARG A 106ARG A 60ILE A 101 | None | 0.72A | 1uobA-4gk6A:undetectable | 1uobA-4gk6A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvz | 26 KDA PERIPLASMICIMMUNOGENIC PROTEIN (Brucellaabortus) |
PF04402(SIMPL) | 3 | ARG A 133ARG A 135ILE A 143 | None | 0.74A | 1uobA-4hvzA:undetectable | 1uobA-4hvzA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyp | HYDROLASE,ALPHA/BETA FOLDFAMILY PROTEIN (Arabidopsisthaliana) |
PF12697(Abhydrolase_6) | 3 | ARG A 123ARG A 199ILE A 201 | None | 0.80A | 1uobA-4jypA:undetectable | 1uobA-4jypA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kxb | GLUTAMYLAMINOPEPTIDASE (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 3 | ARG A 947ARG A 943ILE A 716 | None | 0.78A | 1uobA-4kxbA:undetectable | 1uobA-4kxbA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l15 | FIDGETIN-LIKEPROTEIN 1 (Caenorhabditiselegans) |
PF00004(AAA)PF09336(Vps4_C) | 3 | ARG A 471ARG A 477ILE A 417 | None | 0.81A | 1uobA-4l15A:undetectable | 1uobA-4l15A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4me4 | METAL DEPENDENTPHOSPHOHYDROLASE (Persephonellamarina) |
PF01590(GAF)PF01966(HD) | 3 | ARG A 107ARG A 105ILE A 109 | None | 0.69A | 1uobA-4me4A:undetectable | 1uobA-4me4A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o3m | BLOOM SYNDROMEPROTEIN (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF00570(HRDC)PF09382(RQC)PF16124(RecQ_Zn_bind) | 3 | ARG A 979ARG A 982ILE A 935 | None | 0.57A | 1uobA-4o3mA:undetectable | 1uobA-4o3mA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q25 | PHOSPHATE-SPECIFICTRANSPORT SYSTEMACCESSORY PROTEINPHOU HOMOLOG (Pseudomonasaeruginosa) |
PF01895(PhoU) | 3 | ARG A 203ARG A 199ILE A 133 | None | 0.69A | 1uobA-4q25A:undetectable | 1uobA-4q25A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7y | MINICHROMOSOMEMAINTENANCE PROTEINMCM, CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus;Sulfolobussolfataricus) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 3 | ARG A 110ARG A 211ILE A 107 | None | 0.63A | 1uobA-4r7yA:undetectable | 1uobA-4r7yA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvw | ZNUD (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ARG A 307ARG A 337ILE A 304 | None | 0.81A | 1uobA-4rvwA:undetectable | 1uobA-4rvwA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woj | ASPARTATESEMIALDEHYDEDEHYDROGENASE (Francisellatularensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | ARG A 357ARG A 356ILE A 95 | None | 0.77A | 1uobA-4wojA:undetectable | 1uobA-4wojA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1p | 3-ISOPROPYLMALATEDEHYDROGENASE (Sulfolobusacidocaldarius) |
PF00180(Iso_dh) | 3 | ARG A 117ARG A 96ILE A 217 | IPM A 402 (-2.8A)IPM A 402 (-2.9A)None | 0.79A | 1uobA-4y1pA:undetectable | 1uobA-4y1pA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y2w | ALANINE RACEMASE 1 (Caldanaerobactersubterraneus) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | ARG A 369ARG A 7ILE A 366 | None | 0.80A | 1uobA-4y2wA:undetectable | 1uobA-4y2wA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnt | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Pseudomonasaeruginosa) |
no annotation | 3 | ARG C 362ARG C 361ILE C 95 | None | 0.67A | 1uobA-5bntC:undetectable | 1uobA-5bntC:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cct | DUTPASE (Staphylococcusvirus 80alpha) |
PF00692(dUTPase) | 3 | ARG A 134ARG A 64ILE A 129 | None | 0.77A | 1uobA-5cctA:undetectable | 1uobA-5cctA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ck0 | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | ARG A 225ARG A 156ILE A 190 | None | 0.73A | 1uobA-5ck0A:undetectable | 1uobA-5ck0A:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cr9 | ABC-TYPEFE3+-HYDROXAMATETRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Saccharomonosporaviridis) |
PF01497(Peripla_BP_2) | 3 | ARG A 183ARG A 186ILE A 174 | None | 0.79A | 1uobA-5cr9A:undetectable | 1uobA-5cr9A:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyu | CONSERVED MEMBRANEPROTEIN (Mycolicibacteriumsmegmatis) |
PF05108(T7SS_ESX1_EccB) | 3 | ARG A 367ARG A 368ILE A 364 | None | 0.68A | 1uobA-5cyuA:undetectable | 1uobA-5cyuA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5do8 | LMO0184 PROTEIN (Listeriamonocytogenes) |
no annotation | 3 | ARG B 413ARG B 417ILE B 408 | BGC B 601 ( 3.1A)BGC B 601 ( 4.8A)None | 0.82A | 1uobA-5do8B:undetectable | 1uobA-5do8B:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7h | T-CELLIMMUNOGLOBULIN ANDMUCINDOMAIN-CONTAININGPROTEIN 4 (Homo sapiens) |
no annotation | 3 | ARG B 64ARG B 58ILE B 69 | None | 0.71A | 1uobA-5f7hB:undetectable | 1uobA-5f7hB:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsm | EXO-BETA-D-GLUCOSAMINIDASE (Thermococcuskodakarensis) |
PF02449(Glyco_hydro_42) | 3 | ARG A 266ARG A 269ILE A 275 | None | 0.82A | 1uobA-5gsmA:undetectable | 1uobA-5gsmA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig8 | ATP GRASP LIGASE (Microcystisaeruginosa) |
no annotation | 3 | ARG A 80ARG A 79ILE A 125 | None | 0.80A | 1uobA-5ig8A:undetectable | 1uobA-5ig8A:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jb3 | 30S RIBOSOMALPROTEIN S3 (Pyrococcusabyssi) |
PF00189(Ribosomal_S3_C)PF07650(KH_2) | 3 | ARG Z 63ARG Z 67ILE Z 80 | None | 0.82A | 1uobA-5jb3Z:undetectable | 1uobA-5jb3Z:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kc8 | GLUTAMATE RECEPTORIONOTROPIC, DELTA-2 (Homo sapiens) |
PF01094(ANF_receptor) | 3 | ARG A 276ARG A 275ILE A 278 | None | 0.79A | 1uobA-5kc8A:undetectable | 1uobA-5kc8A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5knh | DARPIN 6G9 (syntheticconstruct) |
PF12796(Ank_2) | 3 | ARG D 56ARG D 90ILE D 95 | None | 0.66A | 1uobA-5knhD:undetectable | 1uobA-5knhD:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2e | GLUTAMATE RECEPTORIONOTROPIC,DELTA-2,GLUTAMATERECEPTOR IONOTROPIC,DELTA-2 (Rattusnorvegicus) |
PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 3 | ARG A 276ARG A 275ILE A 278 | None | 0.82A | 1uobA-5l2eA:undetectable | 1uobA-5l2eA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 3 | ARG A 310ARG A 312ILE A 584 | FAD A 901 (-4.2A)NoneNone | 0.68A | 1uobA-5l3dA:undetectable | 1uobA-5l3dA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5le9 | DD_OFF7_09_3G124 (syntheticconstruct) |
PF00023(Ank)PF12796(Ank_2) | 3 | ARG A 178ARG A 212ILE A 217 | None | 0.76A | 1uobA-5le9A:undetectable | 1uobA-5le9A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkg | DIGUANYLATEPHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF00563(EAL) | 3 | ARG B 53ARG B 43ILE B 58 | C2E B 304 (-3.7A)C2E B 304 (-2.6A)C2E B 304 ( 4.1A) | 0.75A | 1uobA-5mkgB:undetectable | 1uobA-5mkgB:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqp | GLYCOSIDE HYDROLASEBT_1002 (Bacteroidesthetaiotaomicron) |
no annotation | 3 | ARG A 83ARG A 51ILE A 312 | None | 0.77A | 1uobA-5mqpA:undetectable | 1uobA-5mqpA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwr | TETR FAMILYTRANSCRIPTIONALREGULATOR (Sulfolobusacidocaldarius) |
no annotation | 3 | ARG A 142ARG A 143ILE A 146 | None | 0.59A | 1uobA-5mwrA:undetectable | 1uobA-5mwrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd5 | TRANSKETOLASE (Chlamydomonasreinhardtii) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | ARG A 455ARG A 188ILE A 473 | None | 0.78A | 1uobA-5nd5A:undetectable | 1uobA-5nd5A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 3 | ARG T 817ARG T 813ILE T 863 | None | 0.83A | 1uobA-5ojsT:undetectable | 1uobA-5ojsT:6.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t09 | TYPE III SECRETIONSYSTEM EFFECTORHOPBA1 (Pseudomonassyringae) |
no annotation | 3 | ARG A 30ARG A 33ILE A 232 | None | 0.63A | 1uobA-5t09A:undetectable | 1uobA-5t09A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uti | QUEUINETRNA-RIBOSYLTRANSFERASE (Zymomonasmobilis) |
no annotation | 3 | ARG A 38ARG A 362ILE A 30 | None | 0.61A | 1uobA-5utiA:undetectable | 1uobA-5utiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8j | CYCLIC GMP-AMPSYNTHASE (Homo sapiens) |
PF03281(Mab-21) | 3 | ARG A 353ARG A 349ILE A 386 | None | 0.61A | 1uobA-5v8jA:undetectable | 1uobA-5v8jA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vjy | DUTP PYROPHOSPHATASE (Naegleriafowleri) |
PF00692(dUTPase) | 3 | ARG A 109ARG A 66ILE A 104 | None | 0.76A | 1uobA-5vjyA:undetectable | 1uobA-5vjyA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vym | BETA-GALACTOSIDASEBGAB (Bifidobacteriumadolescentis) |
PF08532(Glyco_hydro_42M) | 3 | ARG A 33ARG A 37ILE A 6 | None | 0.75A | 1uobA-5vymA:undetectable | 1uobA-5vymA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8d | AUTOINDUCER SYNTHASE (Bradyrhizobiumjaponicum) |
PF00765(Autoind_synth) | 3 | ARG A 69ARG A 24ILE A 5 | None | 0.72A | 1uobA-5w8dA:undetectable | 1uobA-5w8dA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wfc | HISTONE-LYSINE-N-METHYLTRANSFERASE EZH2,POLYCOMB PROTEINSUZ12 CHIMERA (Chaetomiumthermophilum) |
no annotation | 3 | ARG B2627ARG B2631ILE B2614 | None | 0.77A | 1uobA-5wfcB:undetectable | 1uobA-5wfcB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yf0 | - (-) |
no annotation | 3 | ARG A 177ARG A 213ILE A 185 | None | 0.68A | 1uobA-5yf0A:undetectable | 1uobA-5yf0A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yk7 | MAINTENANCE OFMITOCHONDRIALMORPHOLOGY PROTEIN 1 (Zygosaccharomycesrouxii) |
no annotation | 3 | ARG A 379ARG A 337ILE A 301 | None | 0.81A | 1uobA-5yk7A:undetectable | 1uobA-5yk7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bac | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Neisseriagonorrhoeae) |
no annotation | 3 | ARG A 362ARG A 361ILE A 95 | SO4 A 405 (-3.6A)NoneNone | 0.64A | 1uobA-6bacA:undetectable | 1uobA-6bacA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d3u | ULVAN LYASE (Nonlabensulvanivorans) |
no annotation | 3 | ARG A 135ARG A 137ILE A 74 | None | 0.80A | 1uobA-6d3uA:undetectable | 1uobA-6d3uA:undetectable |