SIMILAR PATTERNS OF AMINO ACIDS FOR 1UOB_A_PNNA1311_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8k PROTEIN
(NEUROTROPHIN-3)


(Homo sapiens)
PF00243
(NGF)
3 ARG A 100
ARG A  31
ILE A  28
None
0.76A 1uobA-1b8kA:
0.0
1uobA-1b8kA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI


(Neisseria
gonorrhoeae)
PF09015
(NgoMIV_restric)
3 ARG A 191
ARG A 194
ILE A 231
None
0.76A 1uobA-1fiuA:
0.0
1uobA-1fiuA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnf FIBRONECTIN

(Homo sapiens)
PF00041
(fn3)
3 ARG A1358
ARG A1360
ILE A1410
None
0.74A 1uobA-1fnfA:
0.0
1uobA-1fnfA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB


(Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
3 ARG A   2
ARG A  32
ILE A 118
None
0.72A 1uobA-1iirA:
0.0
1uobA-1iirA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE


(Pyrococcus
horikoshii)
PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2)
3 ARG A 207
ARG A 348
ILE A 212
G  D 938 ( 4.4A)
None
None
0.80A 1uobA-1j2bA:
0.0
1uobA-1j2bA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME


(Geobacillus
stearothermophilus)
PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2)
3 ARG A 160
ARG A 163
ILE A 141
None
0.79A 1uobA-1mivA:
0.0
1uobA-1mivA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans)
PF00722
(Glyco_hydro_16)
3 ARG A 246
ARG A 346
ILE A 187
NA  A1007 (-4.1A)
None
None
0.77A 1uobA-1o4zA:
1.5
1uobA-1o4zA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Rattus
norvegicus)
PF01593
(Amino_oxidase)
3 ARG A  45
ARG A  47
ILE A  23
FAD  A 652 (-4.3A)
None
FAD  A 652 (-4.8A)
0.66A 1uobA-1o5wA:
0.0
1uobA-1o5wA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE


(Mycobacterium
tuberculosis)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
3 ARG A 235
ARG A 239
ILE A 219
None
0.67A 1uobA-1qpoA:
0.0
1uobA-1qpoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)


(Rhinovirus A)
PF00073
(Rhv)
3 ARG 1 223
ARG 1 158
ILE 1 235
None
0.62A 1uobA-1r1a1:
undetectable
1uobA-1r1a1:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Escherichia
coli)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ARG A 361
ARG A 360
ILE A  95
None
0.64A 1uobA-1t4bA:
undetectable
1uobA-1t4bA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpr LUCIFERASE

(Lingulodinium
polyedra)
PF10284
(Luciferase_3H)
PF10285
(Luciferase_cat)
3 ARG A1124
ARG A1143
ILE A1163
None
0.80A 1uobA-1vprA:
undetectable
1uobA-1vprA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT


(Streptomyces
coelicolor)
PF01039
(Carboxyl_trans)
3 ARG A 393
ARG A 392
ILE A 528
None
0.77A 1uobA-1xnyA:
undetectable
1uobA-1xnyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens)
PF00004
(AAA)
PF09336
(Vps4_C)
3 ARG A 289
ARG A 295
ILE A 236
None
0.75A 1uobA-1xwiA:
undetectable
1uobA-1xwiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3


(Homo sapiens)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
3 ARG A 336
ARG A 368
ILE A 159
None
0.81A 1uobA-1y8pA:
undetectable
1uobA-1y8pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE


(Danio rerio)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
3 ARG X 603
ARG X 600
ILE X 612
SO4  X 902 ( 2.9A)
SO4  X 902 (-2.8A)
None
0.64A 1uobA-1z3iX:
undetectable
1uobA-1z3iX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
3 ARG A 363
ARG A 411
ILE A 416
None
0.78A 1uobA-1z8lA:
undetectable
1uobA-1z8lA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 ARG A 128
ARG A 118
ILE A  33
None
0.67A 1uobA-1zk7A:
undetectable
1uobA-1zk7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
3 ARG A  73
ARG A  69
ILE A 250
None
0.78A 1uobA-2cx9A:
undetectable
1uobA-2cx9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE


(Pyrococcus
horikoshii)
PF00390
(malic)
PF03949
(Malic_M)
3 ARG A 386
ARG A 383
ILE A 412
None
0.82A 1uobA-2dvmA:
undetectable
1uobA-2dvmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
3 ARG A 310
ARG A 312
ILE A 584
FAD  A1001 (-4.4A)
None
None
0.76A 1uobA-2dw4A:
undetectable
1uobA-2dw4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1


(Bos taurus)
PF00115
(COX1)
3 ARG A 439
ARG A 438
ILE A  37
HEA  A 515 (-3.8A)
HEA  A 516 ( 3.1A)
HEA  A 515 (-4.2A)
0.79A 1uobA-2eijA:
undetectable
1uobA-2eijA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE


(Agrobacterium
fabrum)
PF00348
(polyprenyl_synt)
3 ARG A 227
ARG A 248
ILE A 235
None
0.64A 1uobA-2h8oA:
undetectable
1uobA-2h8oA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00891
(Methyltransf_2)
PF16864
(Dimerisation2)
3 ARG A 218
ARG A 193
ILE A 185
None
0.80A 1uobA-2ip2A:
undetectable
1uobA-2ip2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus)
PF01593
(Amino_oxidase)
3 ARG A  44
ARG A  46
ILE A 255
FAD  A1489 (-3.9A)
None
None
0.80A 1uobA-2jb1A:
undetectable
1uobA-2jb1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN


(Homo sapiens)
PF01823
(MACPF)
3 ARG A 454
ARG A 450
ILE A 434
None
0.79A 1uobA-2qqhA:
undetectable
1uobA-2qqhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III


(Thermus
thermophilus)
PF00115
(COX1)
PF00510
(COX3)
3 ARG A 448
ARG A 447
ILE A  49
HAS  A1015 (-3.9A)
HAS  A1016 ( 3.1A)
HAS  A1015 (-4.1A)
0.78A 1uobA-2yevA:
undetectable
1uobA-2yevA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE


(Archaeoglobus
fulgidus)
PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD)
3 ARG A 418
ARG A 367
ILE A 411
None
0.82A 1uobA-2ztgA:
undetectable
1uobA-2ztgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
3 ARG A 110
ARG A 103
ILE A  78
SO4  A 249 ( 4.6A)
SO4  A 249 (-3.2A)
None
0.76A 1uobA-3aizA:
undetectable
1uobA-3aizA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C


(Oryza sativa)
PF00244
(14-3-3)
3 ARG C  58
ARG C  62
ILE C  90
None
0.82A 1uobA-3axyC:
undetectable
1uobA-3axyC:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Chromohalobacter
salexigens)
PF01370
(Epimerase)
3 ARG A   4
ARG A  30
ILE A  67
None
0.64A 1uobA-3ay3A:
undetectable
1uobA-3ay3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785


(Rhodopseudomonas
palustris)
PF11578
(DUF3237)
3 ARG A 140
ARG A  90
ILE A 147
None
0.54A 1uobA-3c5oA:
undetectable
1uobA-3c5oA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ca9 DEOXYURIDINE
TRIPHOSPHATASE


(Paramecium
bursaria
Chlorella virus
IL3A)
PF00692
(dUTPase)
3 ARG A 106
ARG A  63
ILE A 101
None
0.74A 1uobA-3ca9A:
undetectable
1uobA-3ca9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Burkholderia
pseudomallei)
PF14681
(UPRTase)
3 ARG A 102
ARG A 129
ILE A  98
None
0.69A 1uobA-3dmpA:
undetectable
1uobA-3dmpA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1


(Schizosaccharomyces
pombe)
no annotation 3 ARG C  16
ARG C  15
ILE C  22
None
0.62A 1uobA-3e20C:
undetectable
1uobA-3e20C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN


(Bacteroides
thetaiotaomicron)
PF10282
(Lactonase)
3 ARG A 331
ARG A 300
ILE A 250
None
0.81A 1uobA-3fgbA:
undetectable
1uobA-3fgbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaa UNCHARACTERIZED
PROTEIN TA1441


(Thermoplasma
acidophilum)
PF09754
(PAC2)
3 ARG A  76
ARG A  80
ILE A  64
None
0.71A 1uobA-3gaaA:
undetectable
1uobA-3gaaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in5 DNA POLYMERASE KAPPA

(Homo sapiens)
PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C)
3 ARG A 339
ARG A  97
ILE A 335
None
0.69A 1uobA-3in5A:
undetectable
1uobA-3in5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus)
no annotation 3 ARG A 800
ARG A 862
ILE A 855
None
0.82A 1uobA-3j3iA:
undetectable
1uobA-3j3iA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693


(Bordetella
bronchiseptica)
PF04909
(Amidohydro_2)
3 ARG A 203
ARG A 204
ILE A 197
None
0.74A 1uobA-3k4wA:
undetectable
1uobA-3k4wA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN


(Bacteroides
vulgatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 ARG A 224
ARG A 152
ILE A 193
EDO  A 516 (-3.0A)
EDO  A 516 (-3.8A)
None
0.78A 1uobA-3myvA:
undetectable
1uobA-3myvA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p48 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Saccharomyces
cerevisiae)
PF00692
(dUTPase)
3 ARG A 111
ARG A  68
ILE A 106
None
DUP  A 148 (-3.8A)
None
0.79A 1uobA-3p48A:
undetectable
1uobA-3p48A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Vibrio cholerae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ARG A 361
ARG A 360
ILE A  94
None
0.70A 1uobA-3pzrA:
undetectable
1uobA-3pzrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL


(Homo sapiens)
PF00271
(Helicase_C)
PF12513
(SUV3_C)
3 ARG A 473
ARG A 470
ILE A 351
ANP  A 801 (-3.0A)
ANP  A 801 (-3.0A)
None
0.82A 1uobA-3rc3A:
undetectable
1uobA-3rc3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rft URONATE
DEHYDROGENASE


(Agrobacterium
fabrum)
PF01370
(Epimerase)
3 ARG A   5
ARG A  31
ILE A  68
SO4  A 268 (-3.0A)
None
None
0.81A 1uobA-3rftA:
undetectable
1uobA-3rftA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus)
PF03566
(Peptidase_A21)
3 ARG A 217
ARG A 219
ILE A 157
None
0.69A 1uobA-3s6pA:
undetectable
1uobA-3s6pA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz6 CONSERVED DOMAIN
PROTEIN


(Bacillus
anthracis)
PF05031
(NEAT)
3 ARG A  54
ARG A  57
ILE A 131
None
0.75A 1uobA-3sz6A:
undetectable
1uobA-3sz6A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Burkholderia
thailandensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ARG A 365
ARG A 364
ILE A  94
EDO  A 374 (-3.9A)
EDO  A 374 (-4.3A)
None
0.64A 1uobA-3uw3A:
undetectable
1uobA-3uw3A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdd PROTEIN VP1

(Rhinovirus A)
PF00073
(Rhv)
3 ARG A 219
ARG A 156
ILE A 139
None
0.77A 1uobA-3vddA:
undetectable
1uobA-3vddA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdd PROTEIN VP1

(Rhinovirus A)
PF00073
(Rhv)
3 ARG A 219
ARG A 156
ILE A 231
None
0.82A 1uobA-3vddA:
undetectable
1uobA-3vddA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
3 ARG A 576
ARG A 471
ILE A 525
None
0.70A 1uobA-3wxoA:
undetectable
1uobA-3wxoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf4 DUTPASE

(Staphylococcus
virus 80alpha)
PF00692
(dUTPase)
3 ARG A 134
ARG A  64
ILE A 129
None
0.72A 1uobA-3zf4A:
undetectable
1uobA-3zf4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides)
PF04244
(DPRP)
3 ARG A  89
ARG A  90
ILE A  83
None
0.70A 1uobA-3zxsA:
undetectable
1uobA-3zxsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atf BETA-AGARASE B

(Zobellia
galactanivorans)
PF00722
(Glyco_hydro_16)
3 ARG A 246
ARG A 346
ILE A 187
None
0.67A 1uobA-4atfA:
undetectable
1uobA-4atfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE


(Rhodococcus
jostii)
PF01494
(FAD_binding_3)
3 ARG A 110
ARG A 187
ILE A 215
FAD  A1398 (-2.6A)
FAD  A1398 (-3.6A)
P3A  A1399 (-4.4A)
0.79A 1uobA-4bk1A:
undetectable
1uobA-4bk1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exb PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF00248
(Aldo_ket_red)
3 ARG A 119
ARG A 123
ILE A 129
None
0.73A 1uobA-4exbA:
undetectable
1uobA-4exbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk6 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Mycobacteroides
abscessus)
PF00692
(dUTPase)
3 ARG A 106
ARG A  60
ILE A 101
None
0.72A 1uobA-4gk6A:
undetectable
1uobA-4gk6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvz 26 KDA PERIPLASMIC
IMMUNOGENIC PROTEIN


(Brucella
abortus)
PF04402
(SIMPL)
3 ARG A 133
ARG A 135
ILE A 143
None
0.74A 1uobA-4hvzA:
undetectable
1uobA-4hvzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN


(Arabidopsis
thaliana)
PF12697
(Abhydrolase_6)
3 ARG A 123
ARG A 199
ILE A 201
None
0.80A 1uobA-4jypA:
undetectable
1uobA-4jypA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
3 ARG A 947
ARG A 943
ILE A 716
None
0.78A 1uobA-4kxbA:
undetectable
1uobA-4kxbA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1


(Caenorhabditis
elegans)
PF00004
(AAA)
PF09336
(Vps4_C)
3 ARG A 471
ARG A 477
ILE A 417
None
0.81A 1uobA-4l15A:
undetectable
1uobA-4l15A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me4 METAL DEPENDENT
PHOSPHOHYDROLASE


(Persephonella
marina)
PF01590
(GAF)
PF01966
(HD)
3 ARG A 107
ARG A 105
ILE A 109
None
0.69A 1uobA-4me4A:
undetectable
1uobA-4me4A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind)
3 ARG A 979
ARG A 982
ILE A 935
None
0.57A 1uobA-4o3mA:
undetectable
1uobA-4o3mA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q25 PHOSPHATE-SPECIFIC
TRANSPORT SYSTEM
ACCESSORY PROTEIN
PHOU HOMOLOG


(Pseudomonas
aeruginosa)
PF01895
(PhoU)
3 ARG A 203
ARG A 199
ILE A 133
None
0.69A 1uobA-4q25A:
undetectable
1uobA-4q25A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21


(Pyrococcus
furiosus;
Sulfolobus
solfataricus)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
3 ARG A 110
ARG A 211
ILE A 107
None
0.63A 1uobA-4r7yA:
undetectable
1uobA-4r7yA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 ARG A 307
ARG A 337
ILE A 304
None
0.81A 1uobA-4rvwA:
undetectable
1uobA-4rvwA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE


(Francisella
tularensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ARG A 357
ARG A 356
ILE A  95
None
0.77A 1uobA-4wojA:
undetectable
1uobA-4wojA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE


(Sulfolobus
acidocaldarius)
PF00180
(Iso_dh)
3 ARG A 117
ARG A  96
ILE A 217
IPM  A 402 (-2.8A)
IPM  A 402 (-2.9A)
None
0.79A 1uobA-4y1pA:
undetectable
1uobA-4y1pA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 ARG A 369
ARG A   7
ILE A 366
None
0.80A 1uobA-4y2wA:
undetectable
1uobA-4y2wA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Pseudomonas
aeruginosa)
no annotation 3 ARG C 362
ARG C 361
ILE C  95
None
0.67A 1uobA-5bntC:
undetectable
1uobA-5bntC:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cct DUTPASE

(Staphylococcus
virus 80alpha)
PF00692
(dUTPase)
3 ARG A 134
ARG A  64
ILE A 129
None
0.77A 1uobA-5cctA:
undetectable
1uobA-5cctA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
3 ARG A 225
ARG A 156
ILE A 190
None
0.73A 1uobA-5ck0A:
undetectable
1uobA-5ck0A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr9 ABC-TYPE
FE3+-HYDROXAMATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Saccharomonospora
viridis)
PF01497
(Peripla_BP_2)
3 ARG A 183
ARG A 186
ILE A 174
None
0.79A 1uobA-5cr9A:
undetectable
1uobA-5cr9A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN


(Mycolicibacterium
smegmatis)
PF05108
(T7SS_ESX1_EccB)
3 ARG A 367
ARG A 368
ILE A 364
None
0.68A 1uobA-5cyuA:
undetectable
1uobA-5cyuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes)
no annotation 3 ARG B 413
ARG B 417
ILE B 408
BGC  B 601 ( 3.1A)
BGC  B 601 ( 4.8A)
None
0.82A 1uobA-5do8B:
undetectable
1uobA-5do8B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7h T-CELL
IMMUNOGLOBULIN AND
MUCIN
DOMAIN-CONTAINING
PROTEIN 4


(Homo sapiens)
no annotation 3 ARG B  64
ARG B  58
ILE B  69
None
0.71A 1uobA-5f7hB:
undetectable
1uobA-5f7hB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE


(Thermococcus
kodakarensis)
PF02449
(Glyco_hydro_42)
3 ARG A 266
ARG A 269
ILE A 275
None
0.82A 1uobA-5gsmA:
undetectable
1uobA-5gsmA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig8 ATP GRASP LIGASE

(Microcystis
aeruginosa)
no annotation 3 ARG A  80
ARG A  79
ILE A 125
None
0.80A 1uobA-5ig8A:
undetectable
1uobA-5ig8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S3


(Pyrococcus
abyssi)
PF00189
(Ribosomal_S3_C)
PF07650
(KH_2)
3 ARG Z  63
ARG Z  67
ILE Z  80
None
0.82A 1uobA-5jb3Z:
undetectable
1uobA-5jb3Z:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2


(Homo sapiens)
PF01094
(ANF_receptor)
3 ARG A 276
ARG A 275
ILE A 278
None
0.79A 1uobA-5kc8A:
undetectable
1uobA-5kc8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knh DARPIN 6G9

(synthetic
construct)
PF12796
(Ank_2)
3 ARG D  56
ARG D  90
ILE D  95
None
0.66A 1uobA-5knhD:
undetectable
1uobA-5knhD:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2


(Rattus
norvegicus)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
3 ARG A 276
ARG A 275
ILE A 278
None
0.82A 1uobA-5l2eA:
undetectable
1uobA-5l2eA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
3 ARG A 310
ARG A 312
ILE A 584
FAD  A 901 (-4.2A)
None
None
0.68A 1uobA-5l3dA:
undetectable
1uobA-5l3dA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct)
PF00023
(Ank)
PF12796
(Ank_2)
3 ARG A 178
ARG A 212
ILE A 217
None
0.76A 1uobA-5le9A:
undetectable
1uobA-5le9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE


(Pseudomonas
aeruginosa)
PF00563
(EAL)
3 ARG B  53
ARG B  43
ILE B  58
C2E  B 304 (-3.7A)
C2E  B 304 (-2.6A)
C2E  B 304 ( 4.1A)
0.75A 1uobA-5mkgB:
undetectable
1uobA-5mkgB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002


(Bacteroides
thetaiotaomicron)
no annotation 3 ARG A  83
ARG A  51
ILE A 312
None
0.77A 1uobA-5mqpA:
undetectable
1uobA-5mqpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Sulfolobus
acidocaldarius)
no annotation 3 ARG A 142
ARG A 143
ILE A 146
None
0.59A 1uobA-5mwrA:
undetectable
1uobA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
3 ARG A 455
ARG A 188
ILE A 473
None
0.78A 1uobA-5nd5A:
undetectable
1uobA-5nd5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
3 ARG T 817
ARG T 813
ILE T 863
None
0.83A 1uobA-5ojsT:
undetectable
1uobA-5ojsT:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t09 TYPE III SECRETION
SYSTEM EFFECTOR
HOPBA1


(Pseudomonas
syringae)
no annotation 3 ARG A  30
ARG A  33
ILE A 232
None
0.63A 1uobA-5t09A:
undetectable
1uobA-5t09A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE


(Zymomonas
mobilis)
no annotation 3 ARG A  38
ARG A 362
ILE A  30
None
0.61A 1uobA-5utiA:
undetectable
1uobA-5utiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8j CYCLIC GMP-AMP
SYNTHASE


(Homo sapiens)
PF03281
(Mab-21)
3 ARG A 353
ARG A 349
ILE A 386
None
0.61A 1uobA-5v8jA:
undetectable
1uobA-5v8jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjy DUTP PYROPHOSPHATASE

(Naegleria
fowleri)
PF00692
(dUTPase)
3 ARG A 109
ARG A  66
ILE A 104
None
0.76A 1uobA-5vjyA:
undetectable
1uobA-5vjyA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vym BETA-GALACTOSIDASE
BGAB


(Bifidobacterium
adolescentis)
PF08532
(Glyco_hydro_42M)
3 ARG A  33
ARG A  37
ILE A   6
None
0.75A 1uobA-5vymA:
undetectable
1uobA-5vymA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8d AUTOINDUCER SYNTHASE

(Bradyrhizobium
japonicum)
PF00765
(Autoind_synth)
3 ARG A  69
ARG A  24
ILE A   5
None
0.72A 1uobA-5w8dA:
undetectable
1uobA-5w8dA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA


(Chaetomium
thermophilum)
no annotation 3 ARG B2627
ARG B2631
ILE B2614
None
0.77A 1uobA-5wfcB:
undetectable
1uobA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-)
no annotation 3 ARG A 177
ARG A 213
ILE A 185
None
0.68A 1uobA-5yf0A:
undetectable
1uobA-5yf0A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1


(Zygosaccharomyces
rouxii)
no annotation 3 ARG A 379
ARG A 337
ILE A 301
None
0.81A 1uobA-5yk7A:
undetectable
1uobA-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Neisseria
gonorrhoeae)
no annotation 3 ARG A 362
ARG A 361
ILE A  95
SO4  A 405 (-3.6A)
None
None
0.64A 1uobA-6bacA:
undetectable
1uobA-6bacA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans)
no annotation 3 ARG A 135
ARG A 137
ILE A  74
None
0.80A 1uobA-6d3uA:
undetectable
1uobA-6d3uA:
undetectable