SIMILAR PATTERNS OF AMINO ACIDS FOR 1UOB_A_PNNA1311_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlj UDP-GLUCOSE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 SER A 232
LEU A 221
HIS A 248
PHE A 218
ILE A 245
 None
 1.49A 1uobA-1dljA:
undetectable		 1uobA-1dljA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		5 LEU A 158
HIS A 243
ASP A 185
LEU A 223
PHE A 264
 None
FE2  A 901 ( 3.4A)
FE2  A 901 ( 2.2A)
None
AKG  A 902 (-4.9A)
 1.43A 1uobA-1e5iA:
44.6		 1uobA-1e5iA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		12 MET A  73
SER A 102
LEU A 158
MET A 180
HIS A 183
ASP A 185
LEU A 204
HIS A 243
SER A 260
VAL A 262
PHE A 264
ILE A 305
 None
None
None
AKG  A 902 ( 3.7A)
FE2  A 901 ( 3.5A)
FE2  A 901 ( 2.2A)
AKG  A 902 ( 3.7A)
FE2  A 901 ( 3.4A)
AKG  A 902 (-2.8A)
AKG  A 902 ( 4.8A)
AKG  A 902 (-4.9A)
AKG  A 902 (-4.5A)
 0.22A 1uobA-1e5iA:
44.6		 1uobA-1e5iA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		7 SER A 102
LEU A 158
HIS A 243
ASP A 185
SER A 260
VAL A 262
PHE A 264
 None
None
FE2  A 901 ( 3.4A)
FE2  A 901 ( 2.2A)
AKG  A 902 (-2.8A)
AKG  A 902 ( 4.8A)
AKG  A 902 (-4.9A)
 1.36A 1uobA-1e5iA:
44.6		 1uobA-1e5iA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 LEU A 190
LEU A  62
VAL A 196
PHE A 187
ILE A 183
 None
 1.25A 1uobA-1fuuA:
undetectable		 1uobA-1fuuA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcw PROTEIN (HEMOGLOBIN)
PROTEIN (HEMOGLOBIN)

(Mustelus
griseus;
Mustelus
griseus) 		PF00042
(Globin)
PF00042
(Globin) 		5 LEU A 101
HIS A 121
ASP A 125
LEU B  95
ILE A 106
 HEM  A 141 (-4.4A)
None
None
None
None
 1.43A 1uobA-1gcwA:
undetectable		 1uobA-1gcwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		5 LEU A   7
ASP A 201
HIS A 151
SER A  57
VAL A  34
 None
 1.29A 1uobA-1j6oA:
undetectable		 1uobA-1j6oA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8u 6-OXO CAMPHOR
HYDROLASE

(Rhodococcus
erythropolis) 		PF00378
(ECH_1) 		5 SER A 129
LEU A 104
ASP A 154
LEU A 173
HIS A 145
 None
 1.02A 1uobA-1o8uA:
undetectable		 1uobA-1o8uA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 SER A 118
LEU A 116
ASP A 263
HIS A 339
VAL A 122
 None
None
2PG  A 801 ( 4.4A)
2PG  A 801 ( 4.7A)
2PG  A 801 ( 4.9A)
 1.26A 1uobA-1o99A:
undetectable		 1uobA-1o99A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 LEU A 126
LEU A  26
VAL A  92
PHE A 131
ILE A  77
 None
 1.36A 1uobA-1wnoA:
undetectable		 1uobA-1wnoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		5 MET A 101
HIS A 175
ASP A 177
LEU A 206
HIS A 264
 None
FE2  A 450 ( 3.3A)
FE2  A 450 ( 2.8A)
None
FE2  A 450 ( 3.4A)
 1.43A 1uobA-2a1xA:
10.6		 1uobA-2a1xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		5 SER A1924
ASP A1902
HIS A1954
VAL A1927
PHE A1897
 None
 1.28A 1uobA-2adoA:
undetectable		 1uobA-2adoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		5 SER A1924
HIS A1954
ASP A1902
VAL A1927
PHE A1897
 None
 1.20A 1uobA-2adoA:
undetectable		 1uobA-2adoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 LEU B 316
SER B 336
VAL B 332
PHE B 328
ILE B 240
 None
 1.40A 1uobA-2afhB:
undetectable		 1uobA-2afhB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 LEU A 410
LEU A 253
VAL A 232
PHE A 233
ILE A 417
 None
 1.32A 1uobA-2bg9A:
undetectable		 1uobA-2bg9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjs ISOPENICILLIN N
SYNTHETASE

(Aspergillus
nidulans) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 HIS A 214
ASP A 216
LEU A 231
HIS A 270
SER A 281
PHE A 285
 FE  A1323 ( 3.3A)
FE  A1323 ( 2.5A)
None
FE  A1323 (-3.5A)
ACV  A1324 (-2.7A)
ACV  A1324 (-4.6A)
 0.69A 1uobA-2bjsA:
23.1		 1uobA-2bjsA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 HIS A 206
ASP A 360
HIS A 211
SER A 308
PHE A 200
 FE  A1441 ( 3.2A)
FE  A1441 ( 2.0A)
FE  A1441 (-3.3A)
None
EDO  A1442 (-3.7A)
 1.28A 1uobA-2bmoA:
undetectable		 1uobA-2bmoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brt LEUCOANTHOCYANIDIN
DIOXYGENASE

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 HIS A 232
ASP A 234
LEU A 249
HIS A 288
SER A 300
PHE A 304
 FE2  A1350 ( 3.5A)
FE2  A1350 (-2.6A)
AKG  A1351 ( 4.0A)
FE2  A1350 ( 3.5A)
AKG  A1351 (-2.5A)
NAR  A1352 ( 3.5A)
 0.47A 1uobA-2brtA:
22.1		 1uobA-2brtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1i PEPTIDOGLYCAN GLCNAC
DEACETYLASE

(Streptococcus
pneumoniae) 		PF01522
(Polysacc_deac_1) 		5 SER A 327
ASP A 418
LEU A 312
VAL A 301
ILE A 419
 None
 1.20A 1uobA-2c1iA:
undetectable		 1uobA-2c1iA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 SER A 106
LEU A 152
LEU A 231
VAL A  85
ILE A 203
 None
 1.28A 1uobA-2e7jA:
undetectable		 1uobA-2e7jA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		5 ASP A 148
LEU A 219
HIS A 152
PHE A 179
ILE A 149
 ACT  A 238 (-2.7A)
None
ACT  A 238 (-3.8A)
ACT  A 238 (-4.9A)
None
 1.29A 1uobA-2hs5A:
undetectable		 1uobA-2hs5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 SER A 178
LEU A 147
LEU A 291
HIS A 290
PHE A 146
 None
 1.38A 1uobA-2ip2A:
undetectable		 1uobA-2ip2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A  84
HIS A 248
ASP A 336
LEU A 314
HIS A 285
 None
ZN  A 493 (-3.2A)
ZN  A 493 (-2.9A)
None
ZN  A 493 (-3.5A)
 1.19A 1uobA-2pajA:
undetectable		 1uobA-2pajA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE

(Streptomyces
avermitilis) 		PF05721
(PhyH) 		5 LEU A 218
HIS A 137
ASP A 139
SER A 172
PHE A 220
 None
FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
None
OGA  A 268 (-4.9A)
 1.46A 1uobA-2rdsA:
9.9		 1uobA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 SER A 363
LEU A  82
LEU A 286
PHE A  79
ILE A  75
 None
 1.42A 1uobA-2v95A:
undetectable		 1uobA-2v95A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		5 HIS A 283
LEU A 301
HIS A 329
VAL A 343
PHE A 345
 MN  A1006 ( 3.4A)
None
MN  A1006 (-3.5A)
None
None
 0.77A 1uobA-2vqaA:
3.9		 1uobA-2vqaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LEU A 145
LEU A  58
VAL A 134
PHE A 136
ILE A  78
 None
 1.06A 1uobA-2xvgA:
undetectable		 1uobA-2xvgA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE

(Neisseria
meningitidis) 		PF07922
(Glyco_transf_52) 		5 SER A 360
LEU A 326
ASP A 164
HIS A 211
PHE A 215
 None
 1.24A 1uobA-2yk6A:
undetectable		 1uobA-2yk6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtz PUTATIVE CHLORITE
DISMUTASE TA0507

(Thermoplasma
acidophilum) 		PF06778
(Chlor_dismutase) 		5 SER A  88
LEU A   9
VAL A  59
PHE A  61
ILE A  34
 None
 1.25A 1uobA-3dtzA:
undetectable		 1uobA-3dtzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 LEU A 321
LEU A 203
SER A 264
VAL A 261
PHE A 192
 None
 1.38A 1uobA-3emyA:
undetectable		 1uobA-3emyA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		5 SER A 335
LEU A  34
LEU A 304
HIS A 113
VAL A  18
 None
 1.30A 1uobA-3epjA:
undetectable		 1uobA-3epjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 SER A 488
LEU A 470
LEU A 277
VAL A 291
ILE A 479
 None
 1.12A 1uobA-3gdnA:
undetectable		 1uobA-3gdnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 SER B 131
LEU B 129
ASP B 284
HIS B 360
VAL B 135
 None
None
2PG  B 565 ( 4.5A)
3PG  B 564 ( 4.2A)
2PG  B 565 (-4.6A)
 1.23A 1uobA-3igzB:
undetectable		 1uobA-3igzB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 SER A  95
LEU A  93
LEU A 373
VAL A 139
ILE A 108
 None
 1.33A 1uobA-3jtmA:
undetectable		 1uobA-3jtmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		5 LEU A 369
MET A 312
LEU A 253
VAL A 295
ILE A 292
 None
None
GOL  A 439 ( 4.9A)
None
None
 1.36A 1uobA-3k1tA:
undetectable		 1uobA-3k1tA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvs CADHERIN-23

(Mus musculus) 		PF00028
(Cadherin) 		5 SER A  27
LEU A  66
VAL A  64
PHE A  55
ILE A  97
 None
 1.28A 1uobA-3mvsA:
undetectable		 1uobA-3mvsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 LEU A 150
HIS A 173
ASP A 175
HIS A 230
SER A 246
PHE A 250
 None
 0.58A 1uobA-3on7A:
23.2		 1uobA-3on7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 LEU A 150
HIS A 173
ASP A 175
LEU A 190
HIS A 230
PHE A 250
 None
 0.42A 1uobA-3on7A:
23.2		 1uobA-3on7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 HIS A 190
ASP A 192
HIS A 247
SER A 263
PHE A 267
 EDO  A 314 (-4.4A)
None
EDO  A 314 (-4.5A)
None
None
 0.65A 1uobA-3ooxA:
24.0		 1uobA-3ooxA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 HIS A 190
ASP A 192
LEU A 207
HIS A 247
PHE A 267
 EDO  A 314 (-4.4A)
None
EDO  A 314 ( 4.8A)
EDO  A 314 (-4.5A)
None
 0.34A 1uobA-3ooxA:
24.0		 1uobA-3ooxA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 SER A 277
LEU A 274
MET A 185
SER A 237
ILE A 176
 None
 1.42A 1uobA-3opbA:
undetectable		 1uobA-3opbA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF00378
(ECH_1) 		5 SER A   6
LEU A 110
VAL A  50
PHE A  34
ILE A  26
 None
 1.49A 1uobA-3ot6A:
undetectable		 1uobA-3ot6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyz MALATE SYNTHASE

(Haloferax
volcanii) 		PF03328
(HpcH_HpaI) 		5 SER A 150
LEU A 146
MET A  85
VAL A 140
ILE A 105
 None
None
CL  A 704 ( 4.1A)
None
None
 1.45A 1uobA-3oyzA:
undetectable		 1uobA-3oyzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 SER A1158
LEU A1155
LEU A1038
PHE A1152
ILE A1055
 None
 1.39A 1uobA-3s5kA:
undetectable		 1uobA-3s5kA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 SER A 424
LEU A 394
LEU A 342
VAL A 417
PHE A 397
 None
 1.49A 1uobA-3v4pA:
undetectable		 1uobA-3v4pA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 LEU A 410
LEU A 253
VAL A 232
PHE A 233
ILE A 417
 None
 1.32A 1uobA-4booA:
undetectable		 1uobA-4booA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 327
ASP A 366
SER A 356
VAL A 352
ILE A 409
 None
 1.42A 1uobA-4flnA:
undetectable		 1uobA-4flnA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		5 SER A 178
LEU A  41
SER A 172
VAL A  58
ILE A  82
 None
 1.46A 1uobA-4ibnA:
undetectable		 1uobA-4ibnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF13640
(2OG-FeII_Oxy_3) 		5 HIS A 124
ASP A 126
HIS A 183
SER A 194
VAL A 139
 MN  A 401 ( 3.3A)
MN  A 401 ( 2.6A)
MN  A 401 ( 3.3A)
OGA  A 402 ( 3.7A)
OGA  A 402 ( 4.9A)
 1.44A 1uobA-4j25A:
10.3		 1uobA-4j25A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF13640
(2OG-FeII_Oxy_3) 		5 HIS A 124
ASP A 126
LEU A 154
HIS A 183
SER A 194
 MN  A 401 ( 3.3A)
MN  A 401 ( 2.6A)
OGA  A 402 (-3.7A)
MN  A 401 ( 3.3A)
OGA  A 402 ( 3.7A)
 0.61A 1uobA-4j25A:
10.3		 1uobA-4j25A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi) 		no annotation 5 HIS A 229
ASP A 231
LEU A 253
HIS A 279
VAL A 293
 MN  A 401 ( 3.4A)
MN  A 401 ( 2.7A)
OGA  A 413 (-3.8A)
MN  A 401 ( 3.4A)
OGA  A 413 (-4.9A)
 0.68A 1uobA-4lt5A:
8.2		 1uobA-4lt5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 5 SER B 141
LEU B 131
HIS B 127
VAL B  59
ILE B 115
 None
 1.43A 1uobA-4lwoB:
undetectable		 1uobA-4lwoB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhu ECTOINE HYDROXYLASE

(Sphingopyxis
alaskensis) 		PF05721
(PhyH) 		5 LEU A 284
HIS A 144
ASP A 146
LEU A 178
HIS A 245
 None
FE  A 401 (-3.7A)
FE  A 401 (-2.6A)
None
FE  A 401 (-3.9A)
 0.98A 1uobA-4mhuA:
10.7		 1uobA-4mhuA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 222
LEU A 305
VAL A 283
PHE A 219
ILE A 162
 None
 0.97A 1uobA-4mksA:
undetectable		 1uobA-4mksA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ASP B 388
HIS B 237
SER B 214
VAL B 408
PHE B 416
 None
 1.37A 1uobA-4r3zB:
undetectable		 1uobA-4r3zB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
HEMOPEXIN

(Haemophilus
influenzae;
Oryctolagus
cuniculus) 		PF05860
(Haemagg_act)
PF00045
(Hemopexin) 		5 LEU B 137
HIS A 560
ASP B 148
LEU A 552
PHE B 146
 None
 1.30A 1uobA-4rt6B:
undetectable		 1uobA-4rt6B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaa PUTATIVE OXYGENASE

(Streptomyces
viridochromogenes) 		PF05721
(PhyH) 		5 HIS A 125
ASP A 127
LEU A 153
HIS A 196
VAL A 211
 NI  A 301 (-3.4A)
NI  A 301 (-2.5A)
None
NI  A 301 (-3.4A)
None
 0.55A 1uobA-4xaaA:
10.7		 1uobA-4xaaA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		5 HIS A 129
ASP A 131
LEU A 160
HIS A 215
VAL A 230
 NI  A 301 (-3.3A)
NI  A 301 (-2.5A)
None
NI  A 301 ( 3.3A)
AKG  A 303 ( 4.8A)
 0.89A 1uobA-4xacA:
9.7		 1uobA-4xacA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 HIS A 235
ASP A 237
LEU A 252
HIS A 293
SER A 305
PHE A 309
 NA  A 400 (-3.7A)
NA  A 400 (-2.3A)
None
NA  A 400 (-3.7A)
None
None
 0.67A 1uobA-4xaeA:
21.4		 1uobA-4xaeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 SER A 153
LEU A 252
HIS A 293
SER A 305
PHE A 309
 None
None
NA  A 400 (-3.7A)
None
None
 1.39A 1uobA-4xaeA:
21.4		 1uobA-4xaeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 SER A 400
HIS A 419
HIS A 252
VAL A 406
PHE A  99
 None
CU  A 802 (-3.1A)
CU  A 801 (-3.2A)
None
None
 1.48A 1uobA-4yzwA:
undetectable		 1uobA-4yzwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		5 LEU A  56
LEU A 182
VAL A 139
PHE A  64
ILE A 263
 None
 1.33A 1uobA-4zaaA:
undetectable		 1uobA-4zaaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 LEU B 561
ASP B 647
HIS B 324
SER B 383
VAL B 467
 None
 1.22A 1uobA-4zktB:
undetectable		 1uobA-4zktB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3o THYMINE DIOXYGENASE

(Neurospora
crassa) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 HIS A 214
ASP A 216
LEU A 231
HIS A 271
SER A 288
PHE A 292
 CA  A 407 (-3.4A)
CA  A 407 (-2.5A)
None
CA  A 407 (-3.4A)
None
None
 0.82A 1uobA-5c3oA:
23.3		 1uobA-5c3oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3o THYMINE DIOXYGENASE

(Neurospora
crassa) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 SER A 120
HIS A 214
ASP A 216
HIS A 271
PHE A 292
 EDO  A 406 (-3.5A)
CA  A 407 (-3.4A)
CA  A 407 (-2.5A)
CA  A 407 (-3.4A)
None
 1.05A 1uobA-5c3oA:
23.3		 1uobA-5c3oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg9 TET-LIKE DIOXYGENASE

(Naegleria
gruberi) 		no annotation 5 HIS A 229
ASP A 231
LEU A 253
HIS A 279
VAL A 293
 MN  A 403 ( 3.3A)
MN  A 403 ( 2.5A)
AKG  A 402 (-3.7A)
MN  A 403 ( 3.4A)
AKG  A 402 (-4.8A)
 0.65A 1uobA-5cg9A:
8.1		 1uobA-5cg9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		5 HIS A1382
ASP A1384
HIS A1881
SER A1898
VAL A1900
 FE  A2003 (-3.3A)
FE  A2003 ( 2.4A)
FE  A2003 ( 3.2A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
 0.61A 1uobA-5deuA:
7.6		 1uobA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		5 SER A1286
HIS A1881
LEU A1872
SER A1898
VAL A1900
 None
FE  A2003 ( 3.2A)
None
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
 1.50A 1uobA-5deuA:
7.6		 1uobA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 SER A 151
LEU A 211
SER A 188
VAL A 192
ILE A 254
 None
 1.29A 1uobA-5ecoA:
undetectable		 1uobA-5ecoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		5 LEU A 300
ASP A 293
LEU A 330
SER A 276
ILE A 284
 None
 1.31A 1uobA-5ejyA:
undetectable		 1uobA-5ejyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5equ SNON,SNON

(Streptomyces
nogalater) 		PF05721
(PhyH) 		5 MET A 161
HIS A 213
ASP A 132
HIS A 207
SER A 226
 AKG  A 301 ( 3.7A)
FE  A 300 ( 3.2A)
FE  A 300 (-2.2A)
AKG  A 301 (-4.2A)
AKG  A 301 ( 4.9A)
 1.16A 1uobA-5equA:
9.9		 1uobA-5equA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 HIS A 180
ASP A 182
HIS A 237
SER A 163
PHE A 253
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 2.2A)
ZN  A 401 ( 3.3A)
None
None
 1.13A 1uobA-5gjaA:
21.9		 1uobA-5gjaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 HIS A 180
ASP A 182
LEU A 198
HIS A 237
SER A 249
PHE A 253
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 2.2A)
None
ZN  A 401 ( 3.3A)
6PC  A 402 ( 4.5A)
None
 0.62A 1uobA-5gjaA:
21.9		 1uobA-5gjaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 LEU A1044
LEU A1098
VAL A1053
PHE A1055
ILE A1031
 None
 1.49A 1uobA-5h42A:
undetectable		 1uobA-5h42A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 SER A 287
LEU A 292
SER A 322
VAL A 337
ILE A 424
 None
None
None
ATP  A 601 (-4.9A)
None
 1.39A 1uobA-5ie2A:
undetectable		 1uobA-5ie2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 SER A 257
HIS A 288
ASP A 342
HIS A 328
VAL A 293
 None
None
CA  A 608 ( 2.9A)
None
None
 1.36A 1uobA-5k8gA:
undetectable		 1uobA-5k8gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 HIS A 189
ASP A 191
LEU A 206
HIS A 268
PHE A 283
 FE  A 401 (-3.3A)
FE  A 401 (-2.4A)
OGA  A 402 (-3.5A)
FE  A 401 ( 3.2A)
ARG  A 403 ( 4.2A)
 0.50A 1uobA-5lunA:
21.1		 1uobA-5lunA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU A 305
HIS A 290
ASP A 353
SER A 320
PHE A 355
 None
 1.45A 1uobA-5m2nA:
undetectable		 1uobA-5m2nA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A2001
LEU A2028
VAL A1971
PHE A1945
ILE A2014
 None
 1.46A 1uobA-5nugA:
undetectable		 1uobA-5nugA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 6 HIS A 238
ASP A 240
LEU A 256
HIS A 295
SER A 307
PHE A 311
 NI  A 401 ( 3.3A)
NI  A 401 ( 2.5A)
AKG  A 402 (-3.6A)
NI  A 401 ( 3.3A)
AKG  A 402 (-2.5A)
AKG  A 402 (-4.8A)
 0.45A 1uobA-5o9wA:
22.8		 1uobA-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcv 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 1

(Petunia x
hybrida) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 HIS A 177
ASP A 179
LEU A 195
HIS A 234
SER A 246
PHE A 250
 NI  A 401 ( 3.3A)
NI  A 401 ( 2.4A)
1AC  A 402 ( 4.5A)
NI  A 401 ( 3.3A)
None
None
 0.85A 1uobA-5tcvA:
19.6		 1uobA-5tcvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 5 LEU A 197
HIS A 313
ASP A 314
SER A 245
PHE A 194
 None
None
SAM  A 501 ( 4.2A)
SAM  A 501 (-3.5A)
SAM  A 501 (-3.7A)
 1.23A 1uobA-5w7pA:
undetectable		 1uobA-5w7pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 MET A  60
LEU A  91
ASP A  94
LEU A 162
HIS A 117
 None
None
None
None
PLP  A 504 (-3.9A)
 1.46A 1uobA-5x7nA:
undetectable		 1uobA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zm4 DIOXYGENASE ANDA

(Aspergillus
stellatus) 		no annotation 5 LEU A 205
HIS A 135
ASP A 137
SER A 179
PHE A 207
 None
FE  A 301 ( 3.4A)
FE  A 301 (-2.5A)
None
None
 1.48A 1uobA-5zm4A:
10.8		 1uobA-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 HIS A 825
ASP A 827
HIS A 877
VAL A 891
PHE A 893
 FE2  A 934 (-3.6A)
FE2  A 934 ( 2.8A)
FE2  A 934 (-3.5A)
None
None
 0.55A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 HIS A 877
ASP A 827
HIS A 869
VAL A 891
PHE A 893
 FE2  A 934 (-3.5A)
FE2  A 934 ( 2.8A)
None
None
None
 1.23A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 LEU A 808
HIS A 825
HIS A 877
VAL A 891
PHE A 893
 None
FE2  A 934 (-3.6A)
FE2  A 934 (-3.5A)
None
None
 0.79A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 LEU A 808
HIS A 877
HIS A 869
VAL A 891
PHE A 893
 None
FE2  A 934 (-3.5A)
None
None
None
 1.15A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3b UNCHARACTERIZED
PROTEIN

(Streptomyces
cattleya) 		no annotation 5 LEU A 194
MET A 216
SER A 223
VAL A 225
ILE A 197
 None
 1.37A 1uobA-6c3bA:
undetectable		 1uobA-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1

(Sacbrood virus) 		no annotation 5 LEU A 130
LEU A  42
VAL A  47
PHE A  56
ILE A  58
 None
 1.49A 1uobA-6egxA:
undetectable		 1uobA-6egxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 5 LEU A 261
ASP A 237
SER A 391
PHE A 236
ILE A 234
 None
ARG  A 501 ( 4.8A)
None
None
ARG  A 501 (-3.7A)
 1.27A 1uobA-6f34A:
undetectable		 1uobA-6f34A:
undetectable