SIMILAR PATTERNS OF AMINO ACIDS FOR 1UNM_E_DVAE2_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		3 THR A 190
PRO A 187
THR A 188
 None
 0.82A 1unmE-1aunA:
undetectable		 1unmE-1aunA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		3 THR A 192
PRO A 194
THR A 217
 None
 0.85A 1unmE-1cj2A:
undetectable		 1unmE-1cj2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 THR A 109
PRO A 107
THR A 111
 None
 0.71A 1unmE-1cptA:
undetectable		 1unmE-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		3 THR A 396
PRO A 392
THR A 394
 None
 0.87A 1unmE-1e8tA:
undetectable		 1unmE-1e8tA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 THR A   5
PRO A   8
THR A   7
 None
 0.81A 1unmE-1eg1A:
undetectable		 1unmE-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 THR B 768
PRO B 765
THR B 766
 None
 0.80A 1unmE-1ffvB:
undetectable		 1unmE-1ffvB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  64
PRO H  60
THR H  62
 None
 0.82A 1unmE-1h3pH:
undetectable		 1unmE-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 THR A 166
PRO A 201
THR A 199
 None
 0.86A 1unmE-1he3A:
undetectable		 1unmE-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		3 THR A  84
PRO A  72
THR A  70
 None
 0.85A 1unmE-1j3eA:
undetectable		 1unmE-1j3eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 THR A 149
PRO A 146
THR A 147
 None
 0.78A 1unmE-1j3uA:
undetectable		 1unmE-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 THR A  97
PRO A  95
THR A  99
 None
 0.78A 1unmE-1jioA:
undetectable		 1unmE-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I

(Schistocerca
gregaria) 		PF05375
(Pacifastin_I) 		3 THR A   5
PRO A  21
THR A  20
 None
 0.83A 1unmE-1kj0A:
undetectable		 1unmE-1kj0A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		3 THR A 149
PRO A 137
THR A 135
 None
 0.83A 1unmE-1lrrA:
undetectable		 1unmE-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR A 139
PRO A 136
THR A 137
 None
 0.84A 1unmE-1ml4A:
undetectable		 1unmE-1ml4A:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		3 THR A  63
PRO A  60
THR A  61
 None
 0.81A 1unmE-1nwaA:
undetectable		 1unmE-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcv OSMOTIN

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		3 THR A 189
PRO A 186
THR A 187
 None
 0.84A 1unmE-1pcvA:
undetectable		 1unmE-1pcvA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		3 THR A 245
PRO A 241
THR A 243
 None
 0.80A 1unmE-1qyiA:
undetectable		 1unmE-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		3 THR A1032
PRO A1034
THR A1035
 None
 0.83A 1unmE-1ux6A:
undetectable		 1unmE-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A  36
PRO A  37
THR A  37
 None
 0.86A 1unmE-1zlrA:
undetectable		 1unmE-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 THR C  37
PRO C  36
THR C 241
 None
 0.82A 1unmE-1zrtC:
undetectable		 1unmE-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS

(Escherichia
coli) 		PF05307
(Bundlin) 		3 THR A  99
PRO A 137
THR A 136
 None
 0.87A 1unmE-1zwtA:
undetectable		 1unmE-1zwtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 3 THR A 252
PRO A 100
THR A  98
 None
 0.87A 1unmE-2cl2A:
undetectable		 1unmE-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7x ENVELOPE
GLYCOPROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF07948
(Nairovirus_M) 		3 THR A  41
PRO A  43
THR A  35
 None
 0.87A 1unmE-2l7xA:
undetectable		 1unmE-2l7xA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00508
(PPV_E2_N) 		3 THR A 104
PRO A 106
THR A 107
 None
 0.82A 1unmE-2nnuA:
undetectable		 1unmE-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		3 THR A 620
PRO A 617
THR A 618
 None
 0.86A 1unmE-2oceA:
undetectable		 1unmE-2oceA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR A 135
PRO A 132
THR A 133
 None
 0.85A 1unmE-2rgwA:
undetectable		 1unmE-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		3 THR A  66
PRO A  63
THR A  64
 None
 0.76A 1unmE-2v7zA:
undetectable		 1unmE-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 THR A 230
PRO A 186
THR A 228
 None
 0.76A 1unmE-2v9qA:
undetectable		 1unmE-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Pseudomonas
aeruginosa) 		PF03548
(LolA) 		3 THR A 106
PRO A 109
THR A 108
 None
 0.85A 1unmE-2w7qA:
undetectable		 1unmE-2w7qA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.87A 1unmE-2xn6A:
undetectable		 1unmE-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.77A 1unmE-2z5xA:
undetectable		 1unmE-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 THR A 113
PRO A 117
THR A 115
 None
 0.81A 1unmE-3ai7A:
undetectable		 1unmE-3ai7A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		3 THR A  96
PRO A  93
THR A  94
 None
 0.83A 1unmE-3d6jA:
undetectable		 1unmE-3d6jA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		3 THR A 704
PRO A 700
THR A 702
 None
 0.78A 1unmE-3fg6A:
undetectable		 1unmE-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmt PROTEIN SEQA

(Escherichia
coli) 		PF03925
(SeqA)
PF17206
(SeqA_N) 		3 THR A 149
PRO A 137
THR A 135
 None
 0.84A 1unmE-3fmtA:
undetectable		 1unmE-3fmtA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		3 THR A 166
PRO A 165
THR A 147
 None
 0.83A 1unmE-3h1qA:
undetectable		 1unmE-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 THR A 638
PRO A 635
THR A 636
 None
 0.62A 1unmE-3ikmA:
undetectable		 1unmE-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens) 		PF00787
(PX) 		3 THR A 135
PRO A 132
THR A 133
 None
 0.86A 1unmE-3iq2A:
undetectable		 1unmE-3iq2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.76A 1unmE-3k9dA:
undetectable		 1unmE-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		3 THR A  48
PRO A 195
THR A  46
 None
 0.84A 1unmE-3krvA:
undetectable		 1unmE-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR A 139
PRO A 136
THR A 137
 None
 0.80A 1unmE-3lxmA:
undetectable		 1unmE-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 THR A  51
PRO A  50
THR A  53
 None
 0.85A 1unmE-3m9vA:
undetectable		 1unmE-3m9vA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		3 THR A 119
PRO A 116
THR A 117
 None
CL  A 453 ( 4.6A)
CL  A 453 ( 4.4A)
 0.77A 1unmE-3my7A:
undetectable		 1unmE-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 THR A 129
PRO A 125
THR A 127
 None
 0.76A 1unmE-3nz4A:
undetectable		 1unmE-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		3 THR A 367
PRO A 366
THR A 410
 None
 0.82A 1unmE-3p40A:
undetectable		 1unmE-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		3 THR A 270
PRO A 266
THR A 268
 None
 0.81A 1unmE-3q1yA:
undetectable		 1unmE-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 THR A 145
PRO A 142
THR A 143
 None
 0.87A 1unmE-3rd8A:
undetectable		 1unmE-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		3 THR B 346
PRO B 342
THR B 344
 None
 0.72A 1unmE-3sc2B:
undetectable		 1unmE-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsu TLL2057 PROTEIN

(Thermosynechococcus
elongatus) 		no annotation 3 THR A 105
PRO A 102
THR A 103
 None
 0.82A 1unmE-3zsuA:
undetectable		 1unmE-3zsuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens) 		PF12790
(T6SS-SciN) 		3 THR A 145
PRO A 142
THR A 143
 None
 0.81A 1unmE-4a1rA:
undetectable		 1unmE-4a1rA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 THR A 147
PRO A 144
THR A 145
 None
 0.86A 1unmE-4apbA:
undetectable		 1unmE-4apbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 THR A 423
PRO A 420
THR A 421
 None
 0.74A 1unmE-4av6A:
undetectable		 1unmE-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 3 THR A 297
PRO A 299
THR A 295
 None
 0.71A 1unmE-4btpA:
undetectable		 1unmE-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 THR A 647
PRO A 649
THR A 650
 None
 0.78A 1unmE-4byfA:
undetectable		 1unmE-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		3 THR A 468
PRO A 465
THR A 466
 None
 0.85A 1unmE-4c02A:
undetectable		 1unmE-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 248
PRO A 252
THR A 250
 None
 0.86A 1unmE-4dzaA:
undetectable		 1unmE-4dzaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		3 THR A 176
PRO A 173
THR A 174
 None
 0.78A 1unmE-4eogA:
undetectable		 1unmE-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		3 THR A 211
PRO A 209
THR A 210
 None
 0.85A 1unmE-4f1hA:
undetectable		 1unmE-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		3 THR A 217
PRO A 192
THR A 194
 None
 0.83A 1unmE-4fd0A:
undetectable		 1unmE-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		3 THR A 217
PRO A 192
THR A 194
 None
 0.82A 1unmE-4fdwA:
undetectable		 1unmE-4fdwA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 THR A 268
PRO A 186
THR A 187
 None
 0.86A 1unmE-4fnqA:
undetectable		 1unmE-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 3 THR A 210
PRO A 234
THR A 232
 None
 0.86A 1unmE-4g4iA:
undetectable		 1unmE-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		3 THR A  66
PRO A  63
THR A  64
 None
 0.87A 1unmE-4hwiA:
undetectable		 1unmE-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		PF08210
(APOBEC_N) 		3 THR A -17
PRO A -20
THR A -19
 None
 0.84A 1unmE-4j4jA:
undetectable		 1unmE-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H 117
PRO H 147
THR H 116
 None
 0.87A 1unmE-4k24H:
undetectable		 1unmE-4k24H:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		3 THR A  50
PRO A  47
THR A  48
 None
 0.86A 1unmE-4kjdA:
undetectable		 1unmE-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN

(Calotropis
procera) 		PF00314
(Thaumatin) 		3 THR A 189
PRO A 186
THR A 187
 None
 0.82A 1unmE-4l2jA:
undetectable		 1unmE-4l2jA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		3 THR A 202
PRO A 198
THR A 200
 None
 0.86A 1unmE-4n8gA:
undetectable		 1unmE-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		3 THR A 684
PRO A 681
THR A 682
 None
 0.87A 1unmE-4ot9A:
undetectable		 1unmE-4ot9A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		3 THR A 259
PRO A 255
THR A 257
 None
 0.77A 1unmE-4ovjA:
undetectable		 1unmE-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		3 THR A 111
PRO A 113
THR A 143
 None
 0.81A 1unmE-4pmhA:
undetectable		 1unmE-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		3 THR A 301
PRO A 303
THR A 165
 None
 0.86A 1unmE-4ry1A:
undetectable		 1unmE-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 THR A 166
PRO A 168
THR A 162
 None
 0.82A 1unmE-4s3jA:
undetectable		 1unmE-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 THR A 231
PRO A 228
THR A 229
 None
 0.81A 1unmE-4u16A:
undetectable		 1unmE-4u16A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 THR A 305
PRO A 302
THR A 303
 None
 0.75A 1unmE-4wzbA:
undetectable		 1unmE-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B

(Homo sapiens) 		no annotation 3 THR L  97
PRO L   8
THR L  10
 None
 0.84A 1unmE-4xnzL:
undetectable		 1unmE-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)

(Chaetomium) 		PF13472
(Lipase_GDSL_2) 		3 THR A 285
PRO A 287
THR A 288
 None
 0.71A 1unmE-4xvhA:
undetectable		 1unmE-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 THR 1  70
PRO 1 188
THR 1  68
 None
 0.85A 1unmE-5ac91:
undetectable		 1unmE-5ac91:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2

(Saccharomyces
cerevisiae) 		PF16843
(Get5_bdg) 		3 THR D  23
PRO D  25
THR D  21
 None
 0.74A 1unmE-5bw8D:
undetectable		 1unmE-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		3 THR A 116
PRO A 113
THR A 114
 None
 0.74A 1unmE-5bwyA:
undetectable		 1unmE-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		3 THR D1946
PRO D1943
THR D1944
 None
 0.74A 1unmE-5disD:
undetectable		 1unmE-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		3 THR B 282
PRO B 278
THR B 388
 None
 0.86A 1unmE-5dynB:
undetectable		 1unmE-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 THR A 390
PRO A 392
THR A 393
 None
 0.82A 1unmE-5eodA:
undetectable		 1unmE-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		3 THR A  64
PRO A  62
THR A  66
 None
 0.77A 1unmE-5hasA:
undetectable		 1unmE-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB

(Bacillus
subtilis) 		PF01638
(HxlR) 		3 THR A  39
PRO A  43
THR A  41
 None
 0.67A 1unmE-5hs8A:
undetectable		 1unmE-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 THR A  56
PRO A  83
THR A  81
 None
 0.85A 1unmE-5ifyA:
undetectable		 1unmE-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		3 THR A 146
PRO A 143
THR A 144
 None
ACT  A1005 (-3.9A)
ACT  A1005 (-3.3A)
 0.74A 1unmE-5j78A:
undetectable		 1unmE-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		3 THR A 203
PRO A 200
THR A 201
 None
 0.77A 1unmE-5jfmA:
undetectable		 1unmE-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		3 THR L  24
PRO L  21
THR L  22
 None
 0.77A 1unmE-5lj3L:
undetectable		 1unmE-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.77A 1unmE-5mqzA:
undetectable		 1unmE-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 3 THR A  77
PRO A 255
THR A  75
 None
 0.81A 1unmE-5nmpA:
undetectable		 1unmE-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4

(Homo sapiens) 		no annotation 3 THR D 388
PRO D 385
THR D 386
 None
 0.75A 1unmE-5of4D:
undetectable		 1unmE-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR B 131
PRO B 127
THR B 129
 None
 0.78A 1unmE-5tteB:
undetectable		 1unmE-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR A 131
PRO A 127
THR A 129
 None
 0.85A 1unmE-5udhA:
undetectable		 1unmE-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		3 THR G 104
PRO G   8
THR G  10
 None
 0.83A 1unmE-5ujzG:
undetectable		 1unmE-5ujzG:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 3 THR A   5
PRO A   8
THR A   7
 THR  A   5 ( 0.8A)
PRO  A   8 ( 1.1A)
THR  A   7 ( 0.8A)
 0.84A 1unmE-5w0aA:
undetectable		 1unmE-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		3 THR A 502
PRO A 504
THR A 505
 None
 0.73A 1unmE-5w1uA:
undetectable		 1unmE-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 THR A 172
PRO A 169
THR A 170
 None
 0.84A 1unmE-5xjnA:
undetectable		 1unmE-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 THR A1076
PRO A1073
THR A1074
 None
 0.80A 1unmE-6bq1A:
undetectable		 1unmE-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 3 THR A 217
PRO A 193
THR A 192
 None
 0.85A 1unmE-6dllA:
undetectable		 1unmE-6dllA:
undetectable