SIMILAR PATTERNS OF AMINO ACIDS FOR 1UNJ_X_DVAX8
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aun | PR-5D (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 188THR A 190PRO A 187 | None | 0.83A | 1unjX-1aunA:undetectable | 1unjX-1aunA:4.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 3 | THR A 111THR A 109PRO A 107 | None | 0.75A | 1unjX-1cptA:undetectable | 1unjX-1cptA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 3 | THR A 7THR A 5PRO A 8 | None | 0.83A | 1unjX-1eg1A:undetectable | 1unjX-1eg1A:4.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu1 | DIMETHYL SULFOXIDEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | THR A 107THR A 109PRO A 106 | None | 0.82A | 1unjX-1eu1A:undetectable | 1unjX-1eu1A:1.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ff9 | SACCHAROPINEREDUCTASE (Magnaporthegrisea) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 3 | THR A 331THR A 339PRO A 332 | None | 0.85A | 1unjX-1ff9A:undetectable | 1unjX-1ff9A:2.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | THR B 766THR B 768PRO B 765 | None | 0.79A | 1unjX-1ffvB:undetectable | 1unjX-1ffvB:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3p | ANTIBODY FABFRAGMENT (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | THR H 62THR H 64PRO H 60 | None | 0.83A | 1unjX-1h3pH:undetectable | 1unjX-1h3pH:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7w | DIHYDROPYRIMIDINEDEHYDROGENASE (Sus scrofa) |
PF01180(DHO_dh)PF07992(Pyr_redox_2)PF14691(Fer4_20)PF14697(Fer4_21) | 3 | THR A 554THR A 555PRO A 553 | None | 0.80A | 1unjX-1h7wA:undetectable | 1unjX-1h7wA:1.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1he3 | BILIVERDIN IX BETAREDUCTASE (Homo sapiens) |
PF13460(NAD_binding_10) | 3 | THR A 199THR A 166PRO A 201 | None | 0.84A | 1unjX-1he3A:undetectable | 1unjX-1he3A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3u | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 147THR A 149PRO A 146 | None | 0.76A | 1unjX-1j3uA:undetectable | 1unjX-1j3uA:2.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 3 | THR A 99THR A 97PRO A 95 | None | 0.79A | 1unjX-1jioA:undetectable | 1unjX-1jioA:7.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kj0 | SERINE PROTEASEINHIBITOR I (Schistocercagregaria) |
PF05375(Pacifastin_I) | 3 | THR A 20THR A 5PRO A 21 | None | 0.81A | 1unjX-1kj0A:undetectable | 1unjX-1kj0A:38.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 135THR A 149PRO A 137 | None | 0.85A | 1unjX-1lrrA:undetectable | 1unjX-1lrrA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhm | S-ADENOSYLMETHIONINEDECARBOXYLASE (Solanumtuberosum) |
PF01536(SAM_decarbox) | 3 | THR A 251THR A 257PRO A 252 | None | 0.85A | 1unjX-1mhmA:undetectable | 1unjX-1mhmA:4.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 137THR A 139PRO A 136 | None | 0.82A | 1unjX-1ml4A:undetectable | 1unjX-1ml4A:3.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nq7 | NUCLEAR RECEPTORROR-BETA (Rattusnorvegicus) |
PF00104(Hormone_recep) | 3 | THR A 415THR A 417PRO A 414 | None | 0.85A | 1unjX-1nq7A:undetectable | 1unjX-1nq7A:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nwa | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA (Mycobacteriumtuberculosis) |
PF01625(PMSR) | 3 | THR A 61THR A 63PRO A 60 | None | 0.84A | 1unjX-1nwaA:undetectable | 1unjX-1nwaA:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcv | OSMOTIN (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 187THR A 189PRO A 186 | None | 0.84A | 1unjX-1pcvA:undetectable | 1unjX-1pcvA:5.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qqh | PAPILLOMAVIRUSTRANSCRIPTION FACTORE2 (Alphapapillomavirus7) |
PF00508(PPV_E2_N) | 3 | THR A 107THR A 104PRO A 106 | None | 0.86A | 1unjX-1qqhA:undetectable | 1unjX-1qqhA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyi | HYPOTHETICAL PROTEIN (Staphylococcusaureus) |
PF13242(Hydrolase_like) | 3 | THR A 243THR A 245PRO A 241 | None | 0.83A | 1unjX-1qyiA:undetectable | 1unjX-1qyiA:2.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | THR A1035THR A1032PRO A1034 | None | 0.78A | 1unjX-1ux6A:undetectable | 1unjX-1ux6A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlr | COAGULATION FACTORXI (Homo sapiens) |
PF00089(Trypsin) | 3 | THR A 37THR A 36PRO A 37 | None | 0.80A | 1unjX-1zlrA:undetectable | 1unjX-1zlrA:4.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | THR C 241THR C 37PRO C 36 | None | 0.84A | 1unjX-1zrtC:undetectable | 1unjX-1zrtC:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2be7 | ASPARTATECARBAMOYLTRANSFERASECATALYTIC CHAIN (Moritellaprofunda) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 136THR A 138PRO A 135 | None | 0.85A | 1unjX-2be7A:undetectable | 1unjX-2be7A:3.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ksk | SUGARCANE DEFENSIN 5 (Saccharumofficinarum) |
PF00304(Gamma-thionin) | 3 | THR A 4THR A 2PRO A 5 | None | 0.84A | 1unjX-2kskA:undetectable | 1unjX-2kskA:8.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ljp | RIBONUCLEASE PPROTEIN COMPONENT (Escherichiacoli) |
PF00825(Ribonuclease_P) | 3 | THR A 30THR A 34PRO A 31 | None | 0.81A | 1unjX-2ljpA:undetectable | 1unjX-2ljpA:8.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nnu | REGULATORY PROTEINE2 (Alphapapillomavirus9) |
PF00508(PPV_E2_N) | 3 | THR A 107THR A 104PRO A 106 | None | 0.77A | 1unjX-2nnuA:undetectable | 1unjX-2nnuA:5.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT BETA (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF16073(SAT) | 3 | THR B 55THR B 56PRO B 54 | None | 0.81A | 1unjX-2pffB:undetectable | 1unjX-2pffB:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgw | ASPARTATECARBAMOYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 133THR A 135PRO A 132 | None | 0.84A | 1unjX-2rgwA:undetectable | 1unjX-2rgwA:3.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rs5 | HUMAN RHINOVIRUS 14COAT PROTEIN(SUBUNIT VP2) (Rhinovirus B) |
PF00073(Rhv) | 3 | THR 2 147THR 2 145PRO 2 149 | None | 0.83A | 1unjX-2rs52:undetectable | 1unjX-2rs52:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7z | HEAT SHOCK COGNATE71 KDA PROTEIN (Rattusnorvegicus) |
PF00012(HSP70) | 3 | THR A 64THR A 66PRO A 63 | None | 0.79A | 1unjX-2v7zA:undetectable | 1unjX-2v7zA:3.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9q | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 3 | THR A 228THR A 230PRO A 186 | None | 0.73A | 1unjX-2v9qA:undetectable | 1unjX-2v9qA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn6 | THYROXINE-BINDINGGLOBULIN (Homo sapiens) |
PF00079(Serpin) | 3 | THR A 41THR A 38PRO A 42 | EDO A1363 ( 3.9A)NoneNone | 0.83A | 1unjX-2xn6A:undetectable | 1unjX-2xn6A:3.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5l | TYLACTONE SYNTHASESTARTER MODULE ANDMODULES 1 & 2 (Streptomycesfradiae) |
PF08659(KR) | 3 | THR A 36THR A 37PRO A 35 | None | 0.82A | 1unjX-2z5lA:undetectable | 1unjX-2z5lA:6.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 3 | THR A 276THR A 278PRO A 274 | NoneNoneFAD A 600 ( 4.9A) | 0.80A | 1unjX-2z5xA:undetectable | 1unjX-2z5xA:1.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 3 | THR A 546THR A 547PRO A 545 | CYN A 605 (-3.7A)NoneCYN A 605 ( 3.6A) | 0.83A | 1unjX-3ayxA:undetectable | 1unjX-3ayxA:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A 150THR A 121PRO A 151 | None | 0.85A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A1150THR A1121PRO A1151 | None | 0.85A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A2150THR A2121PRO A2151 | None | 0.86A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A3150THR A3121PRO A3151 | None | 0.86A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A4150THR A4121PRO A4151 | None | 0.86A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A5150THR A5121PRO A5151 | None | 0.85A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6j | PUTATIVE HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacteroidesfragilis) |
PF13419(HAD_2) | 3 | THR A 94THR A 96PRO A 93 | None | 0.82A | 1unjX-3d6jA:undetectable | 1unjX-3d6jA:4.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg6 | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 3 | THR A 702THR A 704PRO A 700 | None | 0.84A | 1unjX-3fg6A:undetectable | 1unjX-3fg6A:3.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 3 | THR A 147THR A 166PRO A 165 | None | 0.82A | 1unjX-3h1qA:undetectable | 1unjX-3h1qA:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 3 | THR A 636THR A 638PRO A 635 | None | 0.66A | 1unjX-3ikmA:undetectable | 1unjX-3ikmA:0.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iq2 | SORTING NEXIN-7 (Homo sapiens) |
PF00787(PX) | 3 | THR A 133THR A 135PRO A 132 | None | 0.82A | 1unjX-3iq2A:undetectable | 1unjX-3iq2A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 3 | THR A 122THR A 124PRO A 121 | CL A 465 (-4.1A)None CL A 465 (-4.1A) | 0.77A | 1unjX-3k9dA:undetectable | 1unjX-3k9dA:3.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxm | ASPARTATECARBAMOYLTRANSFERASE (Yersinia pestis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 137THR A 139PRO A 136 | None | 0.76A | 1unjX-3lxmA:undetectable | 1unjX-3lxmA:3.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgg | METHYLTRANSFERASE (Methanosarcinamazei) |
PF13847(Methyltransf_31) | 3 | THR A 248THR A 254PRO A 150 | None | 0.84A | 1unjX-3mggA:undetectable | 1unjX-3mggA:7.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mh9 | LIPOPROTEIN LPRG (Mycobacteriumtuberculosis) |
no annotation | 3 | THR C 116THR C 114PRO C 117 | None | 0.82A | 1unjX-3mh9C:undetectable | 1unjX-3mh9C:5.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mha | LIPOPROTEIN LPRG (Mycobacteriumtuberculosis) |
PF07161(LppX_LprAFG) | 3 | THR A 116THR A 114PRO A 117 | None | 0.85A | 1unjX-3mhaA:undetectable | 1unjX-3mhaA:6.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my7 | ALCOHOLDEHYDROGENASE/ACETALDEHYDE DEHYDROGENASE (Vibrioparahaemolyticus) |
PF00171(Aldedh) | 3 | THR A 117THR A 119PRO A 116 | CL A 453 ( 4.4A)None CL A 453 ( 4.6A) | 0.77A | 1unjX-3my7A:undetectable | 1unjX-3my7A:3.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 3 | THR A 127THR A 129PRO A 125 | None | 0.76A | 1unjX-3nz4A:undetectable | 1unjX-3nz4A:1.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 3 | THR A 268THR A 270PRO A 266 | None | 0.81A | 1unjX-3q1yA:undetectable | 1unjX-3q1yA:5.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd8 | FUMARATE HYDRATASECLASS II (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 143THR A 145PRO A 142 | None | 0.85A | 1unjX-3rd8A:undetectable | 1unjX-3rd8A:2.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 3 | THR L 553THR L 554PRO L 552 | NFU L1004 (-3.8A)NoneNFU L1004 (-3.6A) | 0.84A | 1unjX-3rgwL:undetectable | 1unjX-3rgwL:1.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sc2 | SERINECARBOXYPEPTIDASE II(CPDW-II) (Triticumaestivum) |
PF00450(Peptidase_S10) | 3 | THR B 344THR B 346PRO B 342 | None | 0.71A | 1unjX-3sc2B:undetectable | 1unjX-3sc2B:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 3 | THR L 532THR L 533PRO L 531 | FCO L 601 (-3.7A)NoneFCO L 601 (-3.5A) | 0.81A | 1unjX-3uscL:undetectable | 1unjX-3uscL:2.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zsu | TLL2057 PROTEIN (Thermosynechococcuselongatus) |
no annotation | 3 | THR A 103THR A 105PRO A 102 | None | 0.80A | 1unjX-3zsuA:undetectable | 1unjX-3zsuA:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1r | LIP (Serratiamarcescens) |
PF12790(T6SS-SciN) | 3 | THR A 143THR A 145PRO A 142 | None | 0.82A | 1unjX-4a1rA:undetectable | 1unjX-4a1rA:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4apb | FUMARATE HYDRATASECLASS II (Mycobacteriumtuberculosis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 145THR A 147PRO A 144 | None | 0.86A | 1unjX-4apbA:undetectable | 1unjX-4apbA:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 3 | THR A 421THR A 423PRO A 420 | None | 0.72A | 1unjX-4av6A:undetectable | 1unjX-4av6A:2.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 3 | THR A 295THR A 297PRO A 299 | None | 0.68A | 1unjX-4btpA:undetectable | 1unjX-4btpA:3.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 3 | THR A 650THR A 647PRO A 649 | None | 0.74A | 1unjX-4byfA:undetectable | 1unjX-4byfA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 3 | THR A 466THR A 468PRO A 465 | None | 0.85A | 1unjX-4c02A:undetectable | 1unjX-4c02A:3.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 3 | THR A 535THR A 536PRO A 534 | NFU A1004 (-3.7A)NoneNFU A1004 (-3.8A) | 0.85A | 1unjX-4c3oA:undetectable | 1unjX-4c3oA:2.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eog | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09455(Cas_DxTHG) | 3 | THR A 174THR A 176PRO A 173 | None | 0.77A | 1unjX-4eogA:undetectable | 1unjX-4eogA:5.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1h | TYROSYL-DNAPHOSPHODIESTERASE 2 (Danio rerio) |
PF03372(Exo_endo_phos) | 3 | THR A 210THR A 211PRO A 209 | None | 0.74A | 1unjX-4f1hA:undetectable | 1unjX-4f1hA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | THR A 187THR A 268PRO A 186 | None | 0.78A | 1unjX-4fnqA:undetectable | 1unjX-4fnqA:1.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k24 | ANTI-UPAR ANTIBODY,HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | THR H 116THR H 117PRO H 147 | None | 0.80A | 1unjX-4k24H:undetectable | 1unjX-4k24H:7.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjd | INTESTINAL-TYPEALKALINE PHOSPHATASE1 (Rattusnorvegicus) |
PF00245(Alk_phosphatase) | 3 | THR A 48THR A 50PRO A 47 | None | 0.85A | 1unjX-4kjdA:undetectable | 1unjX-4kjdA:2.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l2j | OSMOTIN: ANTIFUNGALLATICIFER PROTEIN (Calotropisprocera) |
PF00314(Thaumatin) | 3 | THR A 187THR A 189PRO A 186 | None | 0.82A | 1unjX-4l2jA:undetectable | 1unjX-4l2jA:3.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n8g | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Chromohalobactersalexigens) |
PF03480(DctP) | 3 | THR A 200THR A 202PRO A 198 | None | 0.85A | 1unjX-4n8gA:undetectable | 1unjX-4n8gA:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oh7 | ORNITHINECARBAMOYLTRANSFERASE (Brucellamelitensis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 186THR A 211PRO A 187 | None | 0.84A | 1unjX-4oh7A:undetectable | 1unjX-4oh7A:3.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovj | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Alicyclobacillusacidocaldarius) |
PF13416(SBP_bac_8) | 3 | THR A 257THR A 259PRO A 255 | None | 0.81A | 1unjX-4ovjA:undetectable | 1unjX-4ovjA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmh | PECTINESTERASE (Sitophilusoryzae) |
PF01095(Pectinesterase) | 3 | THR A 143THR A 111PRO A 113 | None | 0.80A | 1unjX-4pmhA:undetectable | 1unjX-4pmhA:3.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 3 | THR A 162THR A 166PRO A 168 | None | 0.86A | 1unjX-4s3jA:undetectable | 1unjX-4s3jA:2.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u16 | MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Rattusnorvegicus;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 229THR A 231PRO A 228 | None | 0.82A | 1unjX-4u16A:undetectable | 1unjX-4u16A:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uu9 | MEDI7814 (Homo sapiens) |
PF07686(V-set) | 3 | THR B 94THR B 95PRO B 93 | None | 0.86A | 1unjX-4uu9B:undetectable | 1unjX-4uu9B:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uz1 | NOTUM (Homo sapiens) |
PF03283(PAE) | 3 | THR A 284THR A 282PRO A 287 | None | 0.82A | 1unjX-4uz1A:undetectable | 1unjX-4uz1A:2.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 3 | THR A 303THR A 305PRO A 302 | None | 0.77A | 1unjX-4wzbA:undetectable | 1unjX-4wzbA:4.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvh | CARBOHYDRATEESTERASE FAMILY 2(CE2) (Chaetomium) |
PF13472(Lipase_GDSL_2) | 3 | THR A 288THR A 285PRO A 287 | None | 0.66A | 1unjX-4xvhA:undetectable | 1unjX-4xvhA:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bw8 | UBIQUITIN-LIKEPROTEIN MDY2 (Saccharomycescerevisiae) |
PF16843(Get5_bdg) | 3 | THR D 21THR D 23PRO D 25 | None | 0.79A | 1unjX-5bw8D:undetectable | 1unjX-5bw8D:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 3 | THR A 114THR A 116PRO A 113 | None | 0.74A | 1unjX-5bwyA:undetectable | 1unjX-5bwyA:2.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 3 | THR D1944THR D1946PRO D1943 | None | 0.69A | 1unjX-5disD:undetectable | 1unjX-5disD:2.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dyn | PUTATIVE PEPTIDASE (Bacteroidesfragilis) |
PF03415(Peptidase_C11) | 3 | THR B 388THR B 282PRO B 278 | None | 0.77A | 1unjX-5dynB:undetectable | 1unjX-5dynB:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eod | COAGULATION FACTORXI (Homo sapiens) |
PF00024(PAN_1)PF00089(Trypsin) | 3 | THR A 393THR A 390PRO A 392 | None | 0.72A | 1unjX-5eodA:undetectable | 1unjX-5eodA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5has | SEC7 (Thielaviaterrestris) |
PF12783(Sec7_N)PF16213(DCB) | 3 | THR A 66THR A 64PRO A 62 | None | 0.78A | 1unjX-5hasA:undetectable | 1unjX-5hasA:2.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs8 | HTH-TYPETRANSCRIPTIONALREGULATOR YODB (Bacillussubtilis) |
PF01638(HxlR) | 3 | THR A 41THR A 39PRO A 43 | None | 0.68A | 1unjX-5hs8A:undetectable | 1unjX-5hs8A:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j78 | ACETALDEHYDEDEHYDROGENASE(ACETYLATING) (Parageobacillusthermoglucosidasius) |
PF00171(Aldedh) | 3 | THR A 144THR A 146PRO A 143 | ACT A1005 (-3.3A)NoneACT A1005 (-3.9A) | 0.74A | 1unjX-5j78A:undetectable | 1unjX-5j78A:2.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 3 | THR A 201THR A 203PRO A 200 | None | 0.75A | 1unjX-5jfmA:undetectable | 1unjX-5jfmA:3.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj3 | PRE-MRNA-SPLICINGFACTOR BUD31 (Saccharomycescerevisiae) |
PF01125(G10) | 3 | THR L 22THR L 24PRO L 21 | None | 0.77A | 1unjX-5lj3L:undetectable | 1unjX-5lj3L:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqz | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Archaeoglobusfulgidus) |
no annotation | 3 | THR A 228THR A 199PRO A 201 | TAM A 303 (-3.9A)NoneNone | 0.79A | 1unjX-5mqzA:undetectable | 1unjX-5mqzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT4,P52,GENERALTRANSCRIPTION FACTORIIH SUBUNIT 4 (Homo sapiens) |
no annotation | 3 | THR D 386THR D 388PRO D 385 | None | 0.69A | 1unjX-5of4D:undetectable | 1unjX-5of4D:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tte | E3 UBIQUITIN-PROTEINLIGASE ARIH1 (Homo sapiens) |
PF01485(IBR) | 3 | THR B 129THR B 131PRO B 127 | None | 0.79A | 1unjX-5tteB:undetectable | 1unjX-5tteB:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 3 | THR A 505THR A 502PRO A 504 | None | 0.64A | 1unjX-5w1uA:undetectable | 1unjX-5w1uA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjn | CYTOCHROME P450 (Corynebacteriumglutamicum) |
PF00067(p450) | 3 | THR A 170THR A 172PRO A 169 | None | 0.83A | 1unjX-5xjnA:undetectable | 1unjX-5xjnA:2.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyn | PLATINUM SENSITIVITYPROTEIN 3 (Saccharomycescerevisiae) |
no annotation | 3 | THR A 182THR A 209PRO A 181 | None | 0.85A | 1unjX-5xynA:undetectable | 1unjX-5xynA:3.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 3 | THR A1074THR A1076PRO A1073 | None | 0.77A | 1unjX-6bq1A:undetectable | 1unjX-6bq1A:undetectable |