SIMILAR PATTERNS OF AMINO ACIDS FOR 1UNJ_X_DVAX2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aun | PR-5D (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 190PRO A 187THR A 188 | None | 0.80A | 1unjX-1aunA:undetectable | 1unjX-1aunA:4.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 3 | THR A 109PRO A 107THR A 111 | None | 0.75A | 1unjX-1cptA:undetectable | 1unjX-1cptA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 3 | THR A 5PRO A 8THR A 7 | None | 0.81A | 1unjX-1eg1A:undetectable | 1unjX-1eg1A:4.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu1 | DIMETHYL SULFOXIDEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | THR A 109PRO A 106THR A 107 | None | 0.85A | 1unjX-1eu1A:undetectable | 1unjX-1eu1A:1.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | THR B 768PRO B 765THR B 766 | None | 0.81A | 1unjX-1ffvB:undetectable | 1unjX-1ffvB:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3p | ANTIBODY FABFRAGMENT (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | THR H 64PRO H 60THR H 62 | None | 0.82A | 1unjX-1h3pH:undetectable | 1unjX-1h3pH:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7w | DIHYDROPYRIMIDINEDEHYDROGENASE (Sus scrofa) |
PF01180(DHO_dh)PF07992(Pyr_redox_2)PF14691(Fer4_20)PF14697(Fer4_21) | 3 | THR A 555PRO A 553THR A 554 | None | 0.82A | 1unjX-1h7wA:undetectable | 1unjX-1h7wA:1.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1he3 | BILIVERDIN IX BETAREDUCTASE (Homo sapiens) |
PF13460(NAD_binding_10) | 3 | THR A 166PRO A 201THR A 199 | None | 0.86A | 1unjX-1he3A:undetectable | 1unjX-1he3A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3e | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 84PRO A 72THR A 70 | None | 0.86A | 1unjX-1j3eA:undetectable | 1unjX-1j3eA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3u | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 149PRO A 146THR A 147 | None | 0.76A | 1unjX-1j3uA:undetectable | 1unjX-1j3uA:2.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 3 | THR A 97PRO A 95THR A 99 | None | 0.80A | 1unjX-1jioA:undetectable | 1unjX-1jioA:7.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kj0 | SERINE PROTEASEINHIBITOR I (Schistocercagregaria) |
PF05375(Pacifastin_I) | 3 | THR A 5PRO A 21THR A 20 | None | 0.80A | 1unjX-1kj0A:undetectable | 1unjX-1kj0A:38.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 149PRO A 137THR A 135 | None | 0.82A | 1unjX-1lrrA:undetectable | 1unjX-1lrrA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 139PRO A 136THR A 137 | None | 0.82A | 1unjX-1ml4A:undetectable | 1unjX-1ml4A:3.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nwa | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA (Mycobacteriumtuberculosis) |
PF01625(PMSR) | 3 | THR A 63PRO A 60THR A 61 | None | 0.84A | 1unjX-1nwaA:undetectable | 1unjX-1nwaA:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcv | OSMOTIN (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 189PRO A 186THR A 187 | None | 0.84A | 1unjX-1pcvA:undetectable | 1unjX-1pcvA:5.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyi | HYPOTHETICAL PROTEIN (Staphylococcusaureus) |
PF13242(Hydrolase_like) | 3 | THR A 245PRO A 241THR A 243 | None | 0.79A | 1unjX-1qyiA:undetectable | 1unjX-1qyiA:2.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tg5 | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Arabidopsisthaliana) |
PF00903(Glyoxalase) | 3 | THR A 95PRO A 93THR A 94 | None | 0.87A | 1unjX-1tg5A:undetectable | 1unjX-1tg5A:3.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | THR A1032PRO A1034THR A1035 | None | 0.79A | 1unjX-1ux6A:undetectable | 1unjX-1ux6A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlr | COAGULATION FACTORXI (Homo sapiens) |
PF00089(Trypsin) | 3 | THR A 36PRO A 37THR A 37 | None | 0.78A | 1unjX-1zlrA:undetectable | 1unjX-1zlrA:4.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | THR C 37PRO C 36THR C 241 | None | 0.82A | 1unjX-1zrtC:undetectable | 1unjX-1zrtC:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwt | MAJOR STRUCTURALSUBUNIT OFBUNDLE-FORMING PILUS (Escherichiacoli) |
PF05307(Bundlin) | 3 | THR A 99PRO A 137THR A 136 | None | 0.86A | 1unjX-1zwtA:undetectable | 1unjX-1zwtA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2be7 | ASPARTATECARBAMOYLTRANSFERASECATALYTIC CHAIN (Moritellaprofunda) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 138PRO A 135THR A 136 | None | 0.86A | 1unjX-2be7A:undetectable | 1unjX-2be7A:3.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cl2 | PUTATIVELAMINARINASE (Phanerochaetechrysosporium) |
no annotation | 3 | THR A 252PRO A 100THR A 98 | None | 0.86A | 1unjX-2cl2A:undetectable | 1unjX-2cl2A:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ksk | SUGARCANE DEFENSIN 5 (Saccharumofficinarum) |
PF00304(Gamma-thionin) | 3 | THR A 2PRO A 5THR A 4 | None | 0.82A | 1unjX-2kskA:undetectable | 1unjX-2kskA:8.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ljp | RIBONUCLEASE PPROTEIN COMPONENT (Escherichiacoli) |
PF00825(Ribonuclease_P) | 3 | THR A 34PRO A 31THR A 30 | None | 0.81A | 1unjX-2ljpA:undetectable | 1unjX-2ljpA:8.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nnu | REGULATORY PROTEINE2 (Alphapapillomavirus9) |
PF00508(PPV_E2_N) | 3 | THR A 104PRO A 106THR A 107 | None | 0.81A | 1unjX-2nnuA:undetectable | 1unjX-2nnuA:5.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT BETA (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF16073(SAT) | 3 | THR B 56PRO B 54THR B 55 | None | 0.83A | 1unjX-2pffB:undetectable | 1unjX-2pffB:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgw | ASPARTATECARBAMOYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 135PRO A 132THR A 133 | None | 0.86A | 1unjX-2rgwA:undetectable | 1unjX-2rgwA:3.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7z | HEAT SHOCK COGNATE71 KDA PROTEIN (Rattusnorvegicus) |
PF00012(HSP70) | 3 | THR A 66PRO A 63THR A 64 | None | 0.81A | 1unjX-2v7zA:undetectable | 1unjX-2v7zA:3.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9q | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 3 | THR A 230PRO A 186THR A 228 | None | 0.76A | 1unjX-2v9qA:undetectable | 1unjX-2v9qA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn6 | THYROXINE-BINDINGGLOBULIN (Homo sapiens) |
PF00079(Serpin) | 3 | THR A 38PRO A 42THR A 41 | NoneNoneEDO A1363 ( 3.9A) | 0.85A | 1unjX-2xn6A:undetectable | 1unjX-2xn6A:3.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5l | TYLACTONE SYNTHASESTARTER MODULE ANDMODULES 1 & 2 (Streptomycesfradiae) |
PF08659(KR) | 3 | THR A 37PRO A 35THR A 36 | None | 0.83A | 1unjX-2z5lA:undetectable | 1unjX-2z5lA:6.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 3 | THR A 278PRO A 274THR A 276 | NoneFAD A 600 ( 4.9A)None | 0.77A | 1unjX-2z5xA:undetectable | 1unjX-2z5xA:1.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 3 | THR A 547PRO A 545THR A 546 | NoneCYN A 605 ( 3.6A)CYN A 605 (-3.7A) | 0.86A | 1unjX-3ayxA:undetectable | 1unjX-3ayxA:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A 121PRO A 151THR A 150 | None | 0.86A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A1121PRO A1151THR A1150 | None | 0.87A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A2121PRO A2151THR A2150 | None | 0.87A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 3 | THR A5121PRO A5151THR A5150 | None | 0.87A | 1unjX-3cmuA:undetectable | 1unjX-3cmuA:0.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6j | PUTATIVE HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacteroidesfragilis) |
PF13419(HAD_2) | 3 | THR A 96PRO A 93THR A 94 | None | 0.84A | 1unjX-3d6jA:undetectable | 1unjX-3d6jA:4.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg6 | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 3 | THR A 704PRO A 700THR A 702 | None | 0.79A | 1unjX-3fg6A:undetectable | 1unjX-3fg6A:3.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmt | PROTEIN SEQA (Escherichiacoli) |
PF03925(SeqA)PF17206(SeqA_N) | 3 | THR A 149PRO A 137THR A 135 | None | 0.84A | 1unjX-3fmtA:undetectable | 1unjX-3fmtA:5.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 3 | THR A 166PRO A 165THR A 147 | None | 0.83A | 1unjX-3h1qA:undetectable | 1unjX-3h1qA:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 3 | THR A 638PRO A 635THR A 636 | None | 0.61A | 1unjX-3ikmA:undetectable | 1unjX-3ikmA:0.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iq2 | SORTING NEXIN-7 (Homo sapiens) |
PF00787(PX) | 3 | THR A 135PRO A 132THR A 133 | None | 0.83A | 1unjX-3iq2A:undetectable | 1unjX-3iq2A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 3 | THR A 124PRO A 121THR A 122 | None CL A 465 (-4.1A) CL A 465 (-4.1A) | 0.75A | 1unjX-3k9dA:undetectable | 1unjX-3k9dA:3.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxm | ASPARTATECARBAMOYLTRANSFERASE (Yersinia pestis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 139PRO A 136THR A 137 | None | 0.77A | 1unjX-3lxmA:undetectable | 1unjX-3lxmA:3.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgg | METHYLTRANSFERASE (Methanosarcinamazei) |
PF13847(Methyltransf_31) | 3 | THR A 254PRO A 150THR A 248 | None | 0.84A | 1unjX-3mggA:undetectable | 1unjX-3mggA:7.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mh9 | LIPOPROTEIN LPRG (Mycobacteriumtuberculosis) |
no annotation | 3 | THR C 114PRO C 117THR C 116 | None | 0.81A | 1unjX-3mh9C:undetectable | 1unjX-3mh9C:5.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mha | LIPOPROTEIN LPRG (Mycobacteriumtuberculosis) |
PF07161(LppX_LprAFG) | 3 | THR A 114PRO A 117THR A 116 | None | 0.84A | 1unjX-3mhaA:undetectable | 1unjX-3mhaA:6.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my7 | ALCOHOLDEHYDROGENASE/ACETALDEHYDE DEHYDROGENASE (Vibrioparahaemolyticus) |
PF00171(Aldedh) | 3 | THR A 119PRO A 116THR A 117 | None CL A 453 ( 4.6A) CL A 453 ( 4.4A) | 0.74A | 1unjX-3my7A:undetectable | 1unjX-3my7A:3.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 3 | THR A 129PRO A 125THR A 127 | None | 0.73A | 1unjX-3nz4A:undetectable | 1unjX-3nz4A:1.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 3 | THR A 270PRO A 266THR A 268 | None | 0.81A | 1unjX-3q1yA:undetectable | 1unjX-3q1yA:5.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 3 | THR L 554PRO L 552THR L 553 | NoneNFU L1004 (-3.6A)NFU L1004 (-3.8A) | 0.86A | 1unjX-3rgwL:undetectable | 1unjX-3rgwL:1.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sc2 | SERINECARBOXYPEPTIDASE II(CPDW-II) (Triticumaestivum) |
PF00450(Peptidase_S10) | 3 | THR B 346PRO B 342THR B 344 | None | 0.70A | 1unjX-3sc2B:undetectable | 1unjX-3sc2B:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 3 | THR L 533PRO L 531THR L 532 | NoneFCO L 601 (-3.5A)FCO L 601 (-3.7A) | 0.83A | 1unjX-3uscL:undetectable | 1unjX-3uscL:2.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zsu | TLL2057 PROTEIN (Thermosynechococcuselongatus) |
no annotation | 3 | THR A 105PRO A 102THR A 103 | None | 0.83A | 1unjX-3zsuA:undetectable | 1unjX-3zsuA:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1r | LIP (Serratiamarcescens) |
PF12790(T6SS-SciN) | 3 | THR A 145PRO A 142THR A 143 | None | 0.84A | 1unjX-4a1rA:undetectable | 1unjX-4a1rA:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 3 | THR A 423PRO A 420THR A 421 | None | 0.73A | 1unjX-4av6A:undetectable | 1unjX-4av6A:2.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 3 | THR A 297PRO A 299THR A 295 | None | 0.70A | 1unjX-4btpA:undetectable | 1unjX-4btpA:3.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 3 | THR A 647PRO A 649THR A 650 | None | 0.74A | 1unjX-4byfA:undetectable | 1unjX-4byfA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 3 | THR A 536PRO A 534THR A 535 | NoneNFU A1004 (-3.8A)NFU A1004 (-3.7A) | 0.87A | 1unjX-4c3oA:undetectable | 1unjX-4c3oA:2.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eog | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09455(Cas_DxTHG) | 3 | THR A 176PRO A 173THR A 174 | None | 0.80A | 1unjX-4eogA:undetectable | 1unjX-4eogA:5.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1h | TYROSYL-DNAPHOSPHODIESTERASE 2 (Danio rerio) |
PF03372(Exo_endo_phos) | 3 | THR A 211PRO A 209THR A 210 | None | 0.74A | 1unjX-4f1hA:undetectable | 1unjX-4f1hA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fd0 | LEUCINE RICHHYPOTHETICAL PROTEIN (Bacteroidescaccae) |
PF07523(Big_3)PF13306(LRR_5) | 3 | THR A 217PRO A 192THR A 193 | None | 0.86A | 1unjX-4fd0A:undetectable | 1unjX-4fd0A:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | THR A 268PRO A 186THR A 187 | None | 0.78A | 1unjX-4fnqA:undetectable | 1unjX-4fnqA:1.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | HEAT SHOCK COGNATE71 KDA PROTEIN (Homo sapiens) |
PF00012(HSP70) | 3 | THR A 66PRO A 63THR A 64 | None | 0.87A | 1unjX-4hwiA:undetectable | 1unjX-4hwiA:5.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j4j | DNA DC->DU-EDITINGENZYME APOBEC-3F (Homo sapiens) |
PF08210(APOBEC_N) | 3 | THR A -17PRO A -20THR A -19 | None | 0.86A | 1unjX-4j4jA:undetectable | 1unjX-4j4jA:8.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k24 | ANTI-UPAR ANTIBODY,HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | THR H 117PRO H 147THR H 116 | None | 0.79A | 1unjX-4k24H:undetectable | 1unjX-4k24H:7.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l2j | OSMOTIN: ANTIFUNGALLATICIFER PROTEIN (Calotropisprocera) |
PF00314(Thaumatin) | 3 | THR A 189PRO A 186THR A 187 | None | 0.84A | 1unjX-4l2jA:undetectable | 1unjX-4l2jA:3.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n8g | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Chromohalobactersalexigens) |
PF03480(DctP) | 3 | THR A 202PRO A 198THR A 200 | None | 0.85A | 1unjX-4n8gA:undetectable | 1unjX-4n8gA:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oh7 | ORNITHINECARBAMOYLTRANSFERASE (Brucellamelitensis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 211PRO A 187THR A 186 | None | 0.85A | 1unjX-4oh7A:undetectable | 1unjX-4oh7A:3.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovj | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Alicyclobacillusacidocaldarius) |
PF13416(SBP_bac_8) | 3 | THR A 259PRO A 255THR A 257 | None | 0.76A | 1unjX-4ovjA:undetectable | 1unjX-4ovjA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmh | PECTINESTERASE (Sitophilusoryzae) |
PF01095(Pectinesterase) | 3 | THR A 111PRO A 113THR A 143 | None | 0.81A | 1unjX-4pmhA:undetectable | 1unjX-4pmhA:3.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 3 | THR A 166PRO A 168THR A 162 | None | 0.85A | 1unjX-4s3jA:undetectable | 1unjX-4s3jA:2.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u16 | MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Rattusnorvegicus;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 231PRO A 228THR A 229 | None | 0.82A | 1unjX-4u16A:undetectable | 1unjX-4u16A:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uu9 | MEDI7814 (Homo sapiens) |
PF07686(V-set) | 3 | THR B 95PRO B 93THR B 94 | None | 0.86A | 1unjX-4uu9B:undetectable | 1unjX-4uu9B:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uz1 | NOTUM (Homo sapiens) |
PF03283(PAE) | 3 | THR A 282PRO A 287THR A 284 | None | 0.87A | 1unjX-4uz1A:undetectable | 1unjX-4uz1A:2.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 3 | THR A 305PRO A 302THR A 303 | None | 0.78A | 1unjX-4wzbA:undetectable | 1unjX-4wzbA:4.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xnz | LIGHT CHAIN OFANTIBODY VRC06B (Homo sapiens) |
no annotation | 3 | THR L 97PRO L 8THR L 10 | None | 0.85A | 1unjX-4xnzL:undetectable | 1unjX-4xnzL:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvh | CARBOHYDRATEESTERASE FAMILY 2(CE2) (Chaetomium) |
PF13472(Lipase_GDSL_2) | 3 | THR A 285PRO A 287THR A 288 | None | 0.66A | 1unjX-4xvhA:undetectable | 1unjX-4xvhA:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bw8 | UBIQUITIN-LIKEPROTEIN MDY2 (Saccharomycescerevisiae) |
PF16843(Get5_bdg) | 3 | THR D 23PRO D 25THR D 21 | None | 0.80A | 1unjX-5bw8D:undetectable | 1unjX-5bw8D:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 3 | THR A 116PRO A 113THR A 114 | None | 0.72A | 1unjX-5bwyA:undetectable | 1unjX-5bwyA:2.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 3 | THR D1946PRO D1943THR D1944 | None | 0.69A | 1unjX-5disD:undetectable | 1unjX-5disD:2.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dyn | PUTATIVE PEPTIDASE (Bacteroidesfragilis) |
PF03415(Peptidase_C11) | 3 | THR B 282PRO B 278THR B 388 | None | 0.77A | 1unjX-5dynB:undetectable | 1unjX-5dynB:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eod | COAGULATION FACTORXI (Homo sapiens) |
PF00024(PAN_1)PF00089(Trypsin) | 3 | THR A 390PRO A 392THR A 393 | None | 0.76A | 1unjX-5eodA:undetectable | 1unjX-5eodA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5has | SEC7 (Thielaviaterrestris) |
PF12783(Sec7_N)PF16213(DCB) | 3 | THR A 64PRO A 62THR A 66 | None | 0.78A | 1unjX-5hasA:undetectable | 1unjX-5hasA:2.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs8 | HTH-TYPETRANSCRIPTIONALREGULATOR YODB (Bacillussubtilis) |
PF01638(HxlR) | 3 | THR A 39PRO A 43THR A 41 | None | 0.71A | 1unjX-5hs8A:undetectable | 1unjX-5hs8A:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j78 | ACETALDEHYDEDEHYDROGENASE(ACETYLATING) (Parageobacillusthermoglucosidasius) |
PF00171(Aldedh) | 3 | THR A 146PRO A 143THR A 144 | NoneACT A1005 (-3.9A)ACT A1005 (-3.3A) | 0.71A | 1unjX-5j78A:undetectable | 1unjX-5j78A:2.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 3 | THR A 203PRO A 200THR A 201 | None | 0.72A | 1unjX-5jfmA:undetectable | 1unjX-5jfmA:3.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj3 | PRE-MRNA-SPLICINGFACTOR BUD31 (Saccharomycescerevisiae) |
PF01125(G10) | 3 | THR L 24PRO L 21THR L 22 | None | 0.79A | 1unjX-5lj3L:undetectable | 1unjX-5lj3L:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqz | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Archaeoglobusfulgidus) |
no annotation | 3 | THR A 199PRO A 201THR A 228 | NoneNoneTAM A 303 (-3.9A) | 0.80A | 1unjX-5mqzA:undetectable | 1unjX-5mqzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT4,P52,GENERALTRANSCRIPTION FACTORIIH SUBUNIT 4 (Homo sapiens) |
no annotation | 3 | THR D 388PRO D 385THR D 386 | None | 0.67A | 1unjX-5of4D:undetectable | 1unjX-5of4D:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tte | E3 UBIQUITIN-PROTEINLIGASE ARIH1 (Homo sapiens) |
PF01485(IBR) | 3 | THR B 131PRO B 127THR B 129 | None | 0.77A | 1unjX-5tteB:undetectable | 1unjX-5tteB:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udh | E3 UBIQUITIN-PROTEINLIGASE ARIH1 (Homo sapiens) |
PF01485(IBR) | 3 | THR A 131PRO A 127THR A 129 | None | 0.86A | 1unjX-5udhA:undetectable | 1unjX-5udhA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujz | SCFV (Homo sapiens) |
PF07686(V-set) | 3 | THR G 104PRO G 8THR G 10 | None | 0.86A | 1unjX-5ujzG:undetectable | 1unjX-5ujzG:3.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0a | GLUCANASE (Trichodermaharzianum) |
no annotation | 3 | THR A 5PRO A 8THR A 7 | THR A 5 ( 0.8A)PRO A 8 ( 1.1A)THR A 7 ( 0.8A) | 0.86A | 1unjX-5w0aA:undetectable | 1unjX-5w0aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 3 | THR A 502PRO A 504THR A 505 | None | 0.64A | 1unjX-5w1uA:undetectable | 1unjX-5w1uA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjn | CYTOCHROME P450 (Corynebacteriumglutamicum) |
PF00067(p450) | 3 | THR A 172PRO A 169THR A 170 | None | 0.83A | 1unjX-5xjnA:undetectable | 1unjX-5xjnA:2.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 3 | THR A1076PRO A1073THR A1074 | None | 0.81A | 1unjX-6bq1A:undetectable | 1unjX-6bq1A:undetectable |