SIMILAR PATTERNS OF AMINO ACIDS FOR 1UNJ_W_DVAW8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 THR A 188
THR A 190
PRO A 187
None
0.77A 1unjW-1aunA:
undetectable
1unjW-1aunA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 THR A 223
THR A 117
PRO A 224
None
0.84A 1unjW-1bhgA:
undetectable
1unjW-1bhgA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
3 THR A 111
THR A 109
PRO A 107
None
0.72A 1unjW-1cptA:
undetectable
1unjW-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
3 THR A   7
THR A   5
PRO A   8
None
0.76A 1unjW-1eg1A:
undetectable
1unjW-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE


(Rhodobacter
sphaeroides)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
3 THR A 107
THR A 109
PRO A 106
None
0.83A 1unjW-1eu1A:
undetectable
1unjW-1eu1A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 THR B 766
THR B 768
PRO B 765
None
0.76A 1unjW-1ffvB:
undetectable
1unjW-1ffvB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H  62
THR H  64
PRO H  60
None
0.86A 1unjW-1h3pH:
undetectable
1unjW-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 147
THR A 149
PRO A 146
None
0.77A 1unjW-1j3uA:
undetectable
1unjW-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  99
THR A  97
PRO A  95
None
0.79A 1unjW-1jioA:
undetectable
1unjW-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I


(Schistocerca
gregaria)
PF05375
(Pacifastin_I)
3 THR A  20
THR A   5
PRO A  21
None
0.80A 1unjW-1kj0A:
undetectable
1unjW-1kj0A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
3 THR A 135
THR A 149
PRO A 137
None
0.83A 1unjW-1lrrA:
undetectable
1unjW-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE


(Pyrococcus
abyssi)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 137
THR A 139
PRO A 136
None
0.82A 1unjW-1ml4A:
undetectable
1unjW-1ml4A:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq7 NUCLEAR RECEPTOR
ROR-BETA


(Rattus
norvegicus)
PF00104
(Hormone_recep)
3 THR A 415
THR A 417
PRO A 414
None
0.84A 1unjW-1nq7A:
undetectable
1unjW-1nq7A:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA


(Mycobacterium
tuberculosis)
PF01625
(PMSR)
3 THR A  61
THR A  63
PRO A  60
None
0.76A 1unjW-1nwaA:
undetectable
1unjW-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcv OSMOTIN

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 THR A 187
THR A 189
PRO A 186
None
0.81A 1unjW-1pcvA:
undetectable
1unjW-1pcvA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus)
PF13242
(Hydrolase_like)
3 THR A 243
THR A 245
PRO A 241
None
0.85A 1unjW-1qyiA:
undetectable
1unjW-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
3 THR A1035
THR A1032
PRO A1034
None
0.80A 1unjW-1ux6A:
undetectable
1unjW-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
3 THR A  37
THR A  36
PRO A  37
None
0.85A 1unjW-1zlrA:
undetectable
1unjW-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 THR C 241
THR C  37
PRO C  36
None
0.84A 1unjW-1zrtC:
undetectable
1unjW-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS


(Escherichia
coli)
PF05307
(Bundlin)
3 THR A 136
THR A  99
PRO A 137
None
0.83A 1unjW-1zwtA:
undetectable
1unjW-1zwtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN


(Moritella
profunda)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 136
THR A 138
PRO A 135
None
0.85A 1unjW-2be7A:
undetectable
1unjW-2be7A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00202
(Aminotran_3)
3 THR A 183
THR A 185
PRO A 182
None
0.86A 1unjW-2jjfA:
undetectable
1unjW-2jjfA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljp RIBONUCLEASE P
PROTEIN COMPONENT


(Escherichia
coli)
PF00825
(Ribonuclease_P)
3 THR A  30
THR A  34
PRO A  31
None
0.83A 1unjW-2ljpA:
undetectable
1unjW-2ljpA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2


(Alphapapillomavirus
9)
PF00508
(PPV_E2_N)
3 THR A 107
THR A 104
PRO A 106
None
0.80A 1unjW-2nnuA:
undetectable
1unjW-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201


(Pseudomonas
aeruginosa)
PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF)
3 THR A 618
THR A 620
PRO A 617
None
0.81A 1unjW-2oceA:
undetectable
1unjW-2oceA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE


(Methanocaldococcus
jannaschii)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 133
THR A 135
PRO A 132
None
0.82A 1unjW-2rgwA:
undetectable
1unjW-2rgwA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN


(Rattus
norvegicus)
PF00012
(HSP70)
3 THR A  64
THR A  66
PRO A  63
None
0.72A 1unjW-2v7zA:
undetectable
1unjW-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A 228
THR A 230
PRO A 186
None
0.74A 1unjW-2v9qA:
undetectable
1unjW-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN


(Pseudomonas
aeruginosa)
PF03548
(LolA)
3 THR A 108
THR A 106
PRO A 109
None
0.81A 1unjW-2w7qA:
undetectable
1unjW-2w7qA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
3 THR A  41
THR A  38
PRO A  42
EDO  A1363 ( 3.9A)
None
None
0.84A 1unjW-2xn6A:
undetectable
1unjW-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 276
THR A 278
PRO A 274
None
None
FAD  A 600 ( 4.9A)
0.82A 1unjW-2z5xA:
undetectable
1unjW-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
3 THR A 115
THR A 113
PRO A 117
None
0.85A 1unjW-3ai7A:
undetectable
1unjW-3ai7A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE


(Bacteroides
thetaiotaomicron)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 THR A   7
THR A   9
PRO A   6
None
0.85A 1unjW-3ct9A:
undetectable
1unjW-3ct9A:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
fragilis)
PF13419
(HAD_2)
3 THR A  94
THR A  96
PRO A  93
None
0.81A 1unjW-3d6jA:
undetectable
1unjW-3d6jA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
3 THR A 702
THR A 704
PRO A 700
None
0.82A 1unjW-3fg6A:
undetectable
1unjW-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmt PROTEIN SEQA

(Escherichia
coli)
PF03925
(SeqA)
PF17206
(SeqA_N)
3 THR A 135
THR A 149
PRO A 137
None
0.84A 1unjW-3fmtA:
undetectable
1unjW-3fmtA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
3 THR A 147
THR A 166
PRO A 165
None
0.82A 1unjW-3h1qA:
undetectable
1unjW-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Ruegeria
pomeroyi)
PF13458
(Peripla_BP_6)
3 THR A 395
THR A 397
PRO A 394
None
0.83A 1unjW-3h5lA:
undetectable
1unjW-3h5lA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 636
THR A 638
PRO A 635
None
0.66A 1unjW-3ikmA:
undetectable
1unjW-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens)
PF00787
(PX)
3 THR A 133
THR A 135
PRO A 132
None
0.83A 1unjW-3iq2A:
undetectable
1unjW-3iq2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
3 THR A 122
THR A 124
PRO A 121
CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
0.74A 1unjW-3k9dA:
undetectable
1unjW-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus)
PF04199
(Cyclase)
3 THR A  46
THR A  48
PRO A 195
None
0.86A 1unjW-3krvA:
undetectable
1unjW-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 137
THR A 139
PRO A 136
None
0.76A 1unjW-3lxmA:
undetectable
1unjW-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis)
no annotation 3 THR C 116
THR C 114
PRO C 117
None
0.85A 1unjW-3mh9C:
undetectable
1unjW-3mh9C:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
3 THR A 117
THR A 119
PRO A 116
CL  A 453 ( 4.4A)
None
CL  A 453 ( 4.6A)
0.76A 1unjW-3my7A:
undetectable
1unjW-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
3 THR A 127
THR A 129
PRO A 125
None
0.79A 1unjW-3nz4A:
undetectable
1unjW-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 THR A 268
THR A 270
PRO A 266
None
0.84A 1unjW-3q1yA:
undetectable
1unjW-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15


(Mycobacterium
marinum)
PF00378
(ECH_1)
3 THR A 197
THR A 199
PRO A 196
None
0.85A 1unjW-3qk8A:
undetectable
1unjW-3qk8A:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II


(Mycolicibacterium
smegmatis)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 143
THR A 145
PRO A 142
None
0.84A 1unjW-3rd8A:
undetectable
1unjW-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 344
THR B 346
PRO B 342
None
0.77A 1unjW-3sc2B:
undetectable
1unjW-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsu TLL2057 PROTEIN

(Thermosynechococcus
elongatus)
no annotation 3 THR A 103
THR A 105
PRO A 102
None
0.78A 1unjW-3zsuA:
undetectable
1unjW-3zsuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens)
PF12790
(T6SS-SciN)
3 THR A 143
THR A 145
PRO A 142
None
0.78A 1unjW-4a1rA:
undetectable
1unjW-4a1rA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II


(Mycobacterium
tuberculosis)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 145
THR A 147
PRO A 144
None
0.84A 1unjW-4apbA:
undetectable
1unjW-4apbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
3 THR A 421
THR A 423
PRO A 420
None
0.72A 1unjW-4av6A:
undetectable
1unjW-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brz HALOALKANE
DEHALOGENASE


(Rhodobacteraceae)
PF00561
(Abhydrolase_1)
3 THR A 203
THR A 205
PRO A 202
None
0.84A 1unjW-4brzA:
undetectable
1unjW-4brzA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 295
THR A 297
PRO A 299
None
0.74A 1unjW-4btpA:
undetectable
1unjW-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC


(Homo sapiens)
PF00063
(Myosin_head)
PF00612
(IQ)
3 THR A 650
THR A 647
PRO A 649
None
0.76A 1unjW-4byfA:
undetectable
1unjW-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
3 THR A 466
THR A 468
PRO A 465
None
0.83A 1unjW-4c02A:
undetectable
1unjW-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09455
(Cas_DxTHG)
3 THR A 174
THR A 176
PRO A 173
None
0.75A 1unjW-4eogA:
undetectable
1unjW-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 210
THR A 211
PRO A 209
None
0.83A 1unjW-4f1hA:
undetectable
1unjW-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
caccae)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 194
THR A 217
PRO A 192
None
0.85A 1unjW-4fd0A:
undetectable
1unjW-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
ovatus)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 194
THR A 217
PRO A 192
None
0.84A 1unjW-4fdwA:
undetectable
1unjW-4fdwA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
3 THR A 187
THR A 268
PRO A 186
None
0.86A 1unjW-4fnqA:
undetectable
1unjW-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN


(Homo sapiens)
PF00012
(HSP70)
3 THR A  64
THR A  66
PRO A  63
None
0.84A 1unjW-4hwiA:
undetectable
1unjW-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F


(Homo sapiens)
PF08210
(APOBEC_N)
3 THR A -19
THR A -17
PRO A -20
None
0.82A 1unjW-4j4jA:
undetectable
1unjW-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1


(Rattus
norvegicus)
PF00245
(Alk_phosphatase)
3 THR A  48
THR A  50
PRO A  47
None
0.83A 1unjW-4kjdA:
undetectable
1unjW-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN


(Calotropis
procera)
PF00314
(Thaumatin)
3 THR A 187
THR A 189
PRO A 186
None
0.77A 1unjW-4l2jA:
undetectable
1unjW-4l2jA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB


(Mycobacterium
tuberculosis)
PF13416
(SBP_bac_8)
3 THR A 334
THR A 336
PRO A 333
None
0.86A 1unjW-4mfiA:
undetectable
1unjW-4mfiA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT


(Homo sapiens)
PF12796
(Ank_2)
3 THR A 682
THR A 684
PRO A 681
None
0.85A 1unjW-4ot9A:
undetectable
1unjW-4ot9A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE


(Leptospira
biflexa)
PF00682
(HMGL-like)
3 THR A 178
THR A 208
PRO A 176
KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
0.86A 1unjW-4ov4A:
undetectable
1unjW-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A 257
THR A 259
PRO A 255
None
0.82A 1unjW-4ovjA:
undetectable
1unjW-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae)
PF01095
(Pectinesterase)
3 THR A 143
THR A 111
PRO A 113
None
0.84A 1unjW-4pmhA:
undetectable
1unjW-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
3 THR A 162
THR A 166
PRO A 168
None
0.86A 1unjW-4s3jA:
undetectable
1unjW-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3


(Rattus
norvegicus;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
3 THR A 229
THR A 231
PRO A 228
None
0.79A 1unjW-4u16A:
undetectable
1unjW-4u16A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
3 THR A 303
THR A 305
PRO A 302
None
0.73A 1unjW-4wzbA:
undetectable
1unjW-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 288
THR A 285
PRO A 287
None
0.67A 1unjW-4xvhA:
undetectable
1unjW-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
3 THR 1  68
THR 1  70
PRO 1 188
None
0.82A 1unjW-5ac91:
undetectable
1unjW-5ac91:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum)
no annotation 3 THR A 280
THR A 282
PRO A 279
None
0.85A 1unjW-5affA:
undetectable
1unjW-5affA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2


(Saccharomyces
cerevisiae)
PF16843
(Get5_bdg)
3 THR D  21
THR D  23
PRO D  25
None
0.79A 1unjW-5bw8D:
undetectable
1unjW-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum)
PF00026
(Asp)
3 THR A 114
THR A 116
PRO A 113
None
0.69A 1unjW-5bwyA:
undetectable
1unjW-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1944
THR D1946
PRO D1943
None
0.71A 1unjW-5disD:
undetectable
1unjW-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 388
THR B 282
PRO B 278
None
0.83A 1unjW-5dynB:
undetectable
1unjW-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 THR A 393
THR A 390
PRO A 392
None
0.78A 1unjW-5eodA:
undetectable
1unjW-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2


(Homo sapiens)
PF00012
(HSP70)
3 THR A  64
THR A  66
PRO A  63
None
0.85A 1unjW-5fpnA:
undetectable
1unjW-5fpnA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
3 THR A  66
THR A  64
PRO A  62
None
0.79A 1unjW-5hasA:
undetectable
1unjW-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB


(Bacillus
subtilis)
PF01638
(HxlR)
3 THR A  41
THR A  39
PRO A  43
None
0.69A 1unjW-5hs8A:
undetectable
1unjW-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
3 THR A 144
THR A 146
PRO A 143
ACT  A1005 (-3.3A)
None
ACT  A1005 (-3.9A)
0.72A 1unjW-5j78A:
undetectable
1unjW-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 197
THR A 195
PRO A 200
1VU  A 601 ( 4.8A)
None
None
0.79A 1unjW-5jfmA:
undetectable
1unjW-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 201
THR A 203
PRO A 200
None
0.75A 1unjW-5jfmA:
undetectable
1unjW-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31


(Saccharomyces
cerevisiae)
PF01125
(G10)
3 THR L  22
THR L  24
PRO L  21
None
0.73A 1unjW-5lj3L:
undetectable
1unjW-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Archaeoglobus
fulgidus)
no annotation 3 THR A 228
THR A 199
PRO A 201
TAM  A 303 (-3.9A)
None
None
0.79A 1unjW-5mqzA:
undetectable
1unjW-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum)
no annotation 3 THR A  75
THR A  77
PRO A 255
None
0.82A 1unjW-5nmpA:
undetectable
1unjW-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 386
THR D 388
PRO D 385
None
0.77A 1unjW-5of4D:
undetectable
1unjW-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR B 129
THR B 131
PRO B 127
None
0.80A 1unjW-5tteB:
undetectable
1unjW-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum)
no annotation 3 THR A   7
THR A   5
PRO A   8
THR  A   7 ( 0.8A)
THR  A   5 ( 0.8A)
PRO  A   8 ( 1.1A)
0.79A 1unjW-5w0aA:
undetectable
1unjW-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 505
THR A 502
PRO A 504
None
0.72A 1unjW-5w1uA:
undetectable
1unjW-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR


(Danio rerio)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R)
3 THR A 538
THR A 500
PRO A 539
None
0.85A 1unjW-5w81A:
undetectable
1unjW-5w81A:
1.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum)
PF00067
(p450)
3 THR A 170
THR A 172
PRO A 169
None
0.82A 1unjW-5xjnA:
undetectable
1unjW-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 3 THR A1074
THR A1076
PRO A1073
None
0.75A 1unjW-6bq1A:
undetectable
1unjW-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE


(Pseudomonas
putida)
no annotation 3 THR A 192
THR A 217
PRO A 193
None
0.80A 1unjW-6dllA:
undetectable
1unjW-6dllA:
undetectable