SIMILAR PATTERNS OF AMINO ACIDS FOR 1UNJ_F_DVAF2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)


(Pseudomonas
fluorescens)
PF01494
(FAD_binding_3)
3 THR A 192
PRO A 194
THR A 217
None
0.84A 1unjF-1cj2A:
undetectable
1unjF-1cj2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
3 THR A 109
PRO A 107
THR A 111
None
0.78A 1unjF-1cptA:
undetectable
1unjF-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
3 THR B 493
PRO B 491
THR B 492
None
FNE  B 543 (-3.7A)
FNE  B 543 (-3.8A)
0.83A 1unjF-1e3dB:
undetectable
1unjF-1e3dB:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE


(Avian
avulavirus 1)
PF00423
(HN)
3 THR A 396
PRO A 392
THR A 394
None
0.86A 1unjF-1e8tA:
undetectable
1unjF-1e8tA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H  64
PRO H  60
THR H  62
None
0.76A 1unjF-1h3pH:
undetectable
1unjF-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
3 THR A 555
PRO A 553
THR A 554
None
0.79A 1unjF-1h7wA:
undetectable
1unjF-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 149
PRO A 146
THR A 147
None
0.81A 1unjF-1j3uA:
undetectable
1unjF-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  97
PRO A  95
THR A  99
None
0.85A 1unjF-1jioA:
undetectable
1unjF-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I


(Schistocerca
gregaria)
PF05375
(Pacifastin_I)
3 THR A   5
PRO A  21
THR A  20
None
0.86A 1unjF-1kj0A:
undetectable
1unjF-1kj0A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)


(Escherichia
coli)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1)
3 THR A 687
PRO A 614
THR A 688
None
0.77A 1unjF-1qafA:
undetectable
1unjF-1qafA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus)
PF13242
(Hydrolase_like)
3 THR A 245
PRO A 241
THR A 243
None
0.71A 1unjF-1qyiA:
undetectable
1unjF-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rin PEA LECTIN

(Pisum sativum)
PF00139
(Lectin_legB)
3 THR A  26
PRO A  13
THR A  27
None
0.80A 1unjF-1rinA:
undetectable
1unjF-1rinA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS


(Escherichia
coli)
PF01614
(IclR)
3 THR A 100
PRO A  98
THR A  99
None
0.85A 1unjF-1tf1A:
undetectable
1unjF-1tf1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Arabidopsis
thaliana)
PF00903
(Glyoxalase)
3 THR A  95
PRO A  93
THR A  94
None
0.83A 1unjF-1tg5A:
undetectable
1unjF-1tg5A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujt KIAA1568 PROTEIN

(Homo sapiens)
PF00041
(fn3)
3 THR A 111
PRO A  29
THR A 112
None
0.79A 1unjF-1ujtA:
undetectable
1unjF-1ujtA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 THR C  37
PRO C  36
THR C 241
None
0.78A 1unjF-1zrtC:
undetectable
1unjF-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 106
PRO A   2
THR A 107
None
0.85A 1unjF-2b42A:
undetectable
1unjF-2b42A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE


(Homo sapiens)
PF03167
(UDG)
3 THR A 196
PRO A 198
THR A 121
None
0.84A 1unjF-2d07A:
undetectable
1unjF-2d07A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgy POSSIBLE EXPORTED
PROTEIN


(Mycobacterium
tuberculosis)
no annotation 3 THR A  17
PRO A  15
THR A  16
None
0.82A 1unjF-2kgyA:
undetectable
1unjF-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksk SUGARCANE DEFENSIN 5

(Saccharum
officinarum)
PF00304
(Gamma-thionin)
3 THR A   2
PRO A   5
THR A   4
None
0.86A 1unjF-2kskA:
undetectable
1unjF-2kskA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2


(Alphapapillomavirus
9)
PF00508
(PPV_E2_N)
3 THR A 104
PRO A 106
THR A 107
None
0.80A 1unjF-2nnuA:
undetectable
1unjF-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
3 THR B  56
PRO B  54
THR B  55
None
0.78A 1unjF-2pffB:
undetectable
1unjF-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
3 THR A 857
PRO A 855
THR A 856
None
0.85A 1unjF-2r6fA:
undetectable
1unjF-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A 230
PRO A 186
THR A 228
None
0.77A 1unjF-2v9qA:
undetectable
1unjF-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A


(Deinococcus
radiodurans)
PF00005
(ABC_tran)
3 THR A 762
PRO A 760
THR A 761
None
0.86A 1unjF-2vf8A:
undetectable
1unjF-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3q INTERLEUKIN-15
RECEPTOR ALPHA CHAIN


(Homo sapiens)
no annotation 3 THR B  57
PRO B  59
THR B  58
None
0.83A 1unjF-2z3qB:
undetectable
1unjF-2z3qB:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2


(Streptomyces
fradiae)
PF08659
(KR)
3 THR A  37
PRO A  35
THR A  36
None
0.80A 1unjF-2z5lA:
undetectable
1unjF-2z5lA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 278
PRO A 274
THR A 276
None
FAD  A 600 ( 4.9A)
None
0.73A 1unjF-2z5xA:
undetectable
1unjF-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
3 THR A 113
PRO A 117
THR A 115
None
0.81A 1unjF-3ai7A:
undetectable
1unjF-3ai7A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
3 THR A 547
PRO A 545
THR A 546
None
CYN  A 605 ( 3.6A)
CYN  A 605 (-3.7A)
0.80A 1unjF-3ayxA:
undetectable
1unjF-3ayxA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
3 THR A 704
PRO A 700
THR A 702
None
0.76A 1unjF-3fg6A:
undetectable
1unjF-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
3 THR A 166
PRO A 165
THR A 147
None
0.81A 1unjF-3h1qA:
undetectable
1unjF-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hag CAPSID PROTEIN

(Orthohepevirus
A)
PF03014
(SP2)
3 THR A 217
PRO A 219
THR A 218
None
0.86A 1unjF-3hagA:
undetectable
1unjF-3hagA:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 108
PRO A   4
THR A 109
None
0.84A 1unjF-3hd8A:
undetectable
1unjF-3hd8A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
3 THR A 196
PRO A 198
THR A 197
None
0.86A 1unjF-3hmjA:
undetectable
1unjF-3hmjA:
0.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1


(Thermus
thermophilus)
PF02074
(Peptidase_M32)
3 THR A 259
PRO A 246
THR A 260
None
0.76A 1unjF-3hoaA:
undetectable
1unjF-3hoaA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Herpetosiphon
aurantiacus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 THR A   4
PRO A   2
THR A   3
None
0.85A 1unjF-3ik4A:
undetectable
1unjF-3ik4A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 638
PRO A 635
THR A 636
None
0.63A 1unjF-3ikmA:
undetectable
1unjF-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
3 THR A 124
PRO A 121
THR A 122
None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
0.82A 1unjF-3k9dA:
undetectable
1unjF-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 139
PRO A 136
THR A 137
None
0.86A 1unjF-3lxmA:
undetectable
1unjF-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei)
PF13847
(Methyltransf_31)
3 THR A 254
PRO A 150
THR A 248
None
0.83A 1unjF-3mggA:
undetectable
1unjF-3mggA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis)
no annotation 3 THR C 114
PRO C 117
THR C 116
None
0.80A 1unjF-3mh9C:
undetectable
1unjF-3mh9C:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis)
PF07161
(LppX_LprAFG)
3 THR A 114
PRO A 117
THR A 116
None
0.82A 1unjF-3mhaA:
undetectable
1unjF-3mhaA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
3 THR A 119
PRO A 116
THR A 117
None
CL  A 453 ( 4.6A)
CL  A 453 ( 4.4A)
0.79A 1unjF-3my7A:
undetectable
1unjF-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nre ALDOSE 1-EPIMERASE

(Escherichia
coli)
PF01263
(Aldose_epim)
3 THR A 225
PRO A 228
THR A 226
None
0.84A 1unjF-3nreA:
undetectable
1unjF-3nreA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
3 THR A 129
PRO A 125
THR A 127
None
0.71A 1unjF-3nz4A:
undetectable
1unjF-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II


(Streptococcus
suis)
PF00155
(Aminotran_1_2)
3 THR A 154
PRO A 152
THR A 153
None
0.86A 1unjF-3op7A:
undetectable
1unjF-3op7A:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens)
PF13927
(Ig_3)
3 THR A 367
PRO A 366
THR A 410
None
0.82A 1unjF-3p40A:
undetectable
1unjF-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 THR A 270
PRO A 266
THR A 268
None
0.76A 1unjF-3q1yA:
undetectable
1unjF-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
3 THR L 554
PRO L 552
THR L 553
None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
0.81A 1unjF-3rgwL:
undetectable
1unjF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 346
PRO B 342
THR B 344
None
0.68A 1unjF-3sc2B:
undetectable
1unjF-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
3 THR L 533
PRO L 531
THR L 532
None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
0.77A 1unjF-3uscL:
undetectable
1unjF-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis)
PF03583
(LIP)
3 THR A  23
PRO A  25
THR A  24
None
0.86A 1unjF-3zpxA:
undetectable
1unjF-3zpxA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
3 THR A  69
PRO A  65
THR A  67
None
0.84A 1unjF-4aioA:
undetectable
1unjF-4aioA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
3 THR A 423
PRO A 420
THR A 421
None
0.78A 1unjF-4av6A:
undetectable
1unjF-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 297
PRO A 299
THR A 295
None
0.71A 1unjF-4btpA:
undetectable
1unjF-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
3 THR A 536
PRO A 534
THR A 535
None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
0.80A 1unjF-4c3oA:
undetectable
1unjF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09455
(Cas_DxTHG)
3 THR A 176
PRO A 173
THR A 174
None
0.85A 1unjF-4eogA:
undetectable
1unjF-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 211
PRO A 209
THR A 210
None
0.73A 1unjF-4f1hA:
undetectable
1unjF-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
caccae)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 217
PRO A 192
THR A 193
None
0.75A 1unjF-4fd0A:
undetectable
1unjF-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
caccae)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 217
PRO A 192
THR A 194
None
0.86A 1unjF-4fd0A:
undetectable
1unjF-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
ovatus)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 217
PRO A 192
THR A 194
None
0.85A 1unjF-4fdwA:
undetectable
1unjF-4fdwA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)


(Mycobacteroides
abscessus)
PF00202
(Aminotran_3)
3 THR A  73
PRO A 423
THR A  72
None
0.86A 1unjF-4ffcA:
undetectable
1unjF-4ffcA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
3 THR A 268
PRO A 186
THR A 187
None
0.81A 1unjF-4fnqA:
undetectable
1unjF-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
3 THR A 148
PRO A 145
THR A 149
P6G  A 305 ( 4.5A)
None
None
0.85A 1unjF-4h16A:
undetectable
1unjF-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H 117
PRO H 147
THR H 116
None
0.72A 1unjF-4k24H:
undetectable
1unjF-4k24H:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN


(Xylanimonas
cellulosilytica)
PF01471
(PG_binding_1)
PF03734
(YkuD)
3 THR A 248
PRO A 250
THR A 249
None
0.86A 1unjF-4lpqA:
undetectable
1unjF-4lpqA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Enterococcus
faecalis)
PF04095
(NAPRTase)
3 THR A 358
PRO A 360
THR A 359
None
None
MLA  A 517 (-3.9A)
0.83A 1unjF-4mzyA:
undetectable
1unjF-4mzyA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Chromohalobacter
salexigens)
PF03480
(DctP)
3 THR A 202
PRO A 198
THR A 200
None
0.84A 1unjF-4n8gA:
undetectable
1unjF-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A 259
PRO A 255
THR A 257
None
0.73A 1unjF-4ovjA:
undetectable
1unjF-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae)
PF01095
(Pectinesterase)
3 THR A 111
PRO A 113
THR A 143
None
0.76A 1unjF-4pmhA:
undetectable
1unjF-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN


(Pectobacterium
atrosepticum)
PF13416
(SBP_bac_8)
3 THR A 301
PRO A 303
THR A 165
None
0.84A 1unjF-4ry1A:
undetectable
1unjF-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
3 THR A 166
PRO A 168
THR A 162
None
0.81A 1unjF-4s3jA:
undetectable
1unjF-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
3 THR A 305
PRO A 302
THR A 303
None
0.84A 1unjF-4wzbA:
undetectable
1unjF-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B


(Homo sapiens)
no annotation 3 THR L  97
PRO L   8
THR L  10
None
0.74A 1unjF-4xnzL:
undetectable
1unjF-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 285
PRO A 287
THR A 288
None
0.80A 1unjF-4xvhA:
undetectable
1unjF-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1


(Gallus gallus)
PF03493
(BK_channel_a)
3 THR C 973
PRO C 975
THR C 974
None
0.85A 1unjF-5a6fC:
undetectable
1unjF-5a6fC:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2


(Saccharomyces
cerevisiae)
PF16843
(Get5_bdg)
3 THR D  23
PRO D  25
THR D  21
None
0.77A 1unjF-5bw8D:
undetectable
1unjF-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum)
PF00026
(Asp)
3 THR A 116
PRO A 113
THR A 114
None
0.86A 1unjF-5bwyA:
undetectable
1unjF-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1946
PRO D1943
THR D1944
None
0.82A 1unjF-5disD:
undetectable
1unjF-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 282
PRO B 278
THR B 388
None
0.83A 1unjF-5dynB:
undetectable
1unjF-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans)
PF02074
(Peptidase_M32)
3 THR A 249
PRO A 236
THR A 250
None
0.83A 1unjF-5givA:
undetectable
1unjF-5givA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
3 THR A  64
PRO A  62
THR A  66
None
0.82A 1unjF-5hasA:
undetectable
1unjF-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB


(Bacillus
subtilis)
PF01638
(HxlR)
3 THR A  39
PRO A  43
THR A  41
None
0.70A 1unjF-5hs8A:
undetectable
1unjF-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Burkholderia
vietnamiensis)
PF00483
(NTP_transferase)
3 THR A  56
PRO A  83
THR A  81
None
0.85A 1unjF-5ifyA:
undetectable
1unjF-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER


(Shigella
flexneri)
PF02395
(Peptidase_S6)
3 THR A  54
PRO A  62
THR A  56
None
0.86A 1unjF-5j44A:
undetectable
1unjF-5j44A:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
3 THR A 146
PRO A 143
THR A 144
None
ACT  A1005 (-3.9A)
ACT  A1005 (-3.3A)
0.78A 1unjF-5j78A:
undetectable
1unjF-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 203
PRO A 200
THR A 201
None
0.79A 1unjF-5jfmA:
undetectable
1unjF-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31


(Saccharomyces
cerevisiae)
PF01125
(G10)
3 THR L  24
PRO L  21
THR L  22
None
0.84A 1unjF-5lj3L:
undetectable
1unjF-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Archaeoglobus
fulgidus)
no annotation 3 THR A 199
PRO A 201
THR A 228
None
None
TAM  A 303 (-3.9A)
0.83A 1unjF-5mqzA:
undetectable
1unjF-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
3 THR A  69
PRO A  67
THR A  68
None
0.78A 1unjF-5ngkA:
undetectable
1unjF-5ngkA:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2v NUCLEOLYSIN TIA-1
ISOFORM P40


(Homo sapiens)
PF00076
(RRM_1)
3 THR A  83
PRO A   6
THR A  82
None
0.86A 1unjF-5o2vA:
undetectable
1unjF-5o2vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 388
PRO D 385
THR D 386
None
0.67A 1unjF-5of4D:
undetectable
1unjF-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR B 131
PRO B 127
THR B 129
None
0.76A 1unjF-5tteB:
undetectable
1unjF-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR A 131
PRO A 127
THR A 129
None
0.80A 1unjF-5udhA:
undetectable
1unjF-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens)
PF07686
(V-set)
3 THR G 104
PRO G   8
THR G  10
None
0.73A 1unjF-5ujzG:
undetectable
1unjF-5ujzG:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 502
PRO A 504
THR A 505
None
0.70A 1unjF-5w1uA:
undetectable
1unjF-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3


(Saccharomyces
cerevisiae)
no annotation 3 THR A 209
PRO A 181
THR A 182
None
0.85A 1unjF-5xynA:
undetectable
1unjF-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 3 THR A1076
PRO A1073
THR A1074
None
0.85A 1unjF-6bq1A:
undetectable
1unjF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-)
no annotation 3 THR M 154
PRO M 150
THR M 152
None
0.85A 1unjF-6criM:
undetectable
1unjF-6criM:
undetectable