SIMILAR PATTERNS OF AMINO ACIDS FOR 1ULV_A_ACRA3000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE


(Thermotoga
maritima)
PF00128
(Alpha-amylase)
PF09083
(DUF1923)
4 GLN A 503
TRP A 437
GLU A 465
LEU A 521
None
1.49A 1ulvA-1gjuA:
3.6
1ulvA-1gjuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1)
PF00740
(Parvo_coat)
4 GLN A 513
TRP A 109
GLU A  78
LEU A 255
None
1.48A 1ulvA-1k3vA:
undetectable
1ulvA-1k3vA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum)
PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N)
5 GLN A 380
TRP A 437
GLU A 438
LEU A 652
TRP A 654
ACR  A 700 (-3.2A)
ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
None
0.35A 1ulvA-1lf9A:
53.0
1ulvA-1lf9A:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5


(Homo sapiens)
PF00149
(Metallophos)
4 GLN X  66
TRP X 109
GLU X  70
TRP X  13
None
None
SO4  X1308 ( 4.0A)
None
1.30A 1ulvA-2bq8X:
0.0
1ulvA-2bq8X:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1


(Homo sapiens)
PF00043
(GST_C)
PF13417
(GST_N_3)
4 GLN A 102
GLU A 173
LEU A 191
TRP A 194
None
1.33A 1ulvA-2c3nA:
3.6
1ulvA-2c3nA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera)
PF00723
(Glyco_hydro_15)
4 GLN A 143
GLU A 210
LEU A 364
TRP A 362
None
ACR  A 995 (-3.7A)
None
None
1.44A 1ulvA-2f6dA:
31.1
1ulvA-2f6dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera)
PF00723
(Glyco_hydro_15)
4 TRP A 209
GLU A 210
LEU A 471
TRP A 473
None
ACR  A 995 (-3.7A)
None
None
0.38A 1ulvA-2f6dA:
31.1
1ulvA-2f6dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0r HEMIN TRANSPORT
PROTEIN HEMS


(Yersinia
enterocolitica)
PF05171
(HemS)
4 GLN A 316
GLU A 305
LEU A 201
TRP A 189
None
1.44A 1ulvA-2j0rA:
0.0
1ulvA-2j0rA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN 2

(Pseudomonas
aeruginosa)
PF00301
(Rubredoxin)
4 GLN B   5
TRP B  30
LEU B  19
TRP B  37
None
1.40A 1ulvA-2v3bB:
undetectable
1ulvA-2v3bB:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
4 GLN A 124
GLU A 179
LEU A 323
TRP A 321
None
BTB  A 620 (-3.6A)
None
None
1.47A 1ulvA-2vn7A:
30.6
1ulvA-2vn7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
4 TRP A 178
GLU A 179
LEU A 419
TRP A 421
None
BTB  A 620 (-3.6A)
None
None
0.40A 1ulvA-2vn7A:
30.6
1ulvA-2vn7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 GLN A 148
GLU A 203
LEU A 343
TRP A 341
None
TRS  A 701 ( 3.8A)
None
None
1.47A 1ulvA-3eqaA:
9.4
1ulvA-3eqaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 TRP A 202
GLU A 203
LEU A 439
TRP A 441
None
TRS  A 701 ( 3.8A)
None
None
0.35A 1ulvA-3eqaA:
9.4
1ulvA-3eqaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4s PROTEASOME ASSEMBLY
CHAPERONE 2


(Saccharomyces
cerevisiae)
PF09754
(PAC2)
4 GLN P 250
GLU P  52
LEU P 219
TRP P  21
None
1.29A 1ulvA-4g4sP:
undetectable
1ulvA-4g4sP:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqk PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58


(Homo sapiens)
PF16739
(CARD_2)
4 GLN A 111
TRP A 167
LEU A 175
TRP A 186
None
1.47A 1ulvA-4nqkA:
undetectable
1ulvA-4nqkA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus)
PF00724
(Oxidored_FMN)
4 GLN A 168
TRP A  89
GLU A 172
LEU A 127
None
1.50A 1ulvA-4tmcA:
undetectable
1ulvA-4tmcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1


(Saccharomyces
pastorianus)
PF00724
(Oxidored_FMN)
4 GLN A 168
TRP A  89
GLU A 172
LEU A 127
None
1.50A 1ulvA-4yncA:
undetectable
1ulvA-4yncA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 GLN A  99
GLU A  96
LEU A   7
TRP A  10
None
1.35A 1ulvA-5cnxA:
undetectable
1ulvA-5cnxA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii)
PF00150
(Cellulase)
4 GLN A 236
TRP A 141
GLU A 158
LEU A 155
None
1.30A 1ulvA-5d9nA:
undetectable
1ulvA-5d9nA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuc SUS TBC1D15 GAP
DOMAIN


(Sus scrofa)
PF00566
(RabGAP-TBC)
4 GLN A 323
TRP A 348
LEU A 334
TRP A 305
None
1.24A 1ulvA-5tucA:
undetectable
1ulvA-5tucA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN


(Ornithorhynchus
anatinus)
no annotation 4 GLN A 276
TRP A 128
GLU A 239
LEU A 300
None
1.49A 1ulvA-6b4mA:
undetectable
1ulvA-6b4mA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum)
no annotation 4 TRP A 212
GLU A 213
LEU A 451
TRP A 453
None
B3P  A 652 (-3.7A)
None
None
0.37A 1ulvA-6fhvA:
30.7
1ulvA-6fhvA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae)
no annotation 4 GLN A 153
GLU A 208
LEU A 349
TRP A 347
None
ACR  A 801 (-3.9A)
None
None
1.44A 1ulvA-6fhwA:
33.6
1ulvA-6fhwA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae)
no annotation 4 TRP A 207
GLU A 208
LEU A 447
TRP A 449
None
ACR  A 801 (-3.9A)
None
None
0.48A 1ulvA-6fhwA:
33.6
1ulvA-6fhwA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum)
no annotation 4 GLN G1110
TRP G1036
GLU G1108
LEU G1132
None
1.32A 1ulvA-6fmlG:
undetectable
1ulvA-6fmlG:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 4 GLN A 148
GLU A 203
LEU A 343
TRP A 341
None
1.45A 1ulvA-6frvA:
31.4
1ulvA-6frvA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 4 TRP A 202
GLU A 203
LEU A 439
TRP A 441
None
0.28A 1ulvA-6frvA:
31.4
1ulvA-6frvA:
6.15