SIMILAR PATTERNS OF AMINO ACIDS FOR 1UHO_A_VDNA1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)
UREASE (BETA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 HIS B  39
TYR C  39
ALA C  99
GLY C  14
PHE C  13
 None
 1.35A 1uhoA-1a5lB:
undetectable		 1uhoA-1a5lB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 1.01A 1uhoA-1auxA:
undetectable		 1uhoA-1auxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 TYR A 368
TYR A 383
ALA A 406
LEU A 401
PHE A 310
 None
HG  A6005 (-4.6A)
None
None
None
 1.47A 1uhoA-1g8kA:
undetectable		 1uhoA-1g8kA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhn CALNEXIN

(Canis lupus) 		PF00262
(Calreticulin) 		5 TYR A 151
PHE A 436
LEU A 123
GLY A 158
PHE A 155
 None
 1.48A 1uhoA-1jhnA:
undetectable		 1uhoA-1jhnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb3 FERRITIN LIGHT CHAIN
1

(Mus musculus) 		PF00210
(Ferritin) 		5 TYR A 137
ALA A  18
LEU A  23
GLN A  73
PHE A  72
 None
 1.28A 1uhoA-1lb3A:
undetectable		 1uhoA-1lb3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB
N15 ALPHA-BETA
T-CELL RECEPTOR

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR E  49
HIS F 100
ALA E  33
PHE E  32
GLY B  16
 None
 1.15A 1uhoA-1nfdE:
undetectable		 1uhoA-1nfdE:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 0.97A 1uhoA-1pk8A:
undetectable		 1uhoA-1pk8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 736
HIS A 737
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.31A 1uhoA-1sojA:
34.7		 1uhoA-1sojA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 TYR A  16
ALA A 197
LEU A 192
GLN A 256
PHE A 252
 None
None
PLP  A 962 (-4.5A)
None
None
 1.27A 1uhoA-1tdjA:
undetectable		 1uhoA-1tdjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 HIS A  85
ALA A  57
LEU A  64
MET A  95
GLY A  96
 None
 1.36A 1uhoA-1v26A:
undetectable		 1uhoA-1v26A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
PHE A 384
GLN A 413
GLY A 415
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
 0.62A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.76A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 211
HIS A 216
GLN A 413
GLY A 415
PHE A 416
 IBM  A 503 (-4.6A)
ZN  A 501 (-3.3A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
 1.43A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 TYR A 375
ALA A 292
LEU A 516
GLY A 523
PHE A 524
 None
 0.87A 1uhoA-2ahwA:
undetectable		 1uhoA-2ahwA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ALA A 134
PHE A 137
LEU A 141
MET A 187
GLY A 188
 None
 1.32A 1uhoA-2aj4A:
undetectable		 1uhoA-2aj4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A  67
ALA A 123
PHE A  69
LEU A 111
GLY A 118
 None
 1.21A 1uhoA-2f7vA:
undetectable		 1uhoA-2f7vA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE

(Bacteroides
thetaiotaomicron) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 TYR A  25
ALA A 103
PHE A 107
LEU A  41
GLY A  29
 None
 1.36A 1uhoA-2j4gA:
undetectable		 1uhoA-2j4gA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		5 ALA A  59
PHE A  56
LEU A  65
GLN A 101
GLY A 102
 None
 1.36A 1uhoA-2jftA:
undetectable		 1uhoA-2jftA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		5 ALA A  59
PHE A  56
LEU A  65
GLN A 101
GLY A 103
 None
 1.30A 1uhoA-2jftA:
undetectable		 1uhoA-2jftA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 HIS A 168
TYR A 286
ALA A 131
MET A 308
GLY A 310
 None
 1.28A 1uhoA-2jjfA:
undetectable		 1uhoA-2jjfA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		5 ALA A  86
LEU A 158
MET A  68
GLY A  69
PHE A 203
 None
 1.43A 1uhoA-2o3iA:
undetectable		 1uhoA-2o3iA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		5 ALA A  83
PHE A 117
LEU A  96
GLY A  64
PHE A  62
 None
 1.45A 1uhoA-2qy6A:
undetectable		 1uhoA-2qy6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		5 ALA A  83
PHE A 117
LEU A  96
GLY A  65
PHE A  62
 None
 1.41A 1uhoA-2qy6A:
undetectable		 1uhoA-2qy6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 371
HIS A 372
PHE A 552
GLN A 581
GLY A 583
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
None
NPV  A   3 (-3.3A)
 0.40A 1uhoA-2qykA:
36.3		 1uhoA-2qykA:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
HIS A 681
PHE A 857
GLN A 887
GLY A 889
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
None
IBM  A   3 (-3.6A)
 0.63A 1uhoA-2r8qA:
38.1		 1uhoA-2r8qA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 ALA A 310
PHE A 313
LEU A 368
GLY A 390
PHE A 392
 None
 1.39A 1uhoA-2w3pA:
undetectable		 1uhoA-2w3pA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 HIS A 316
ALA A 254
LEU A 199
GLY A 535
PHE A 537
 None
 1.02A 1uhoA-2xn1A:
undetectable		 1uhoA-2xn1A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 ALA A 673
PHE A 678
LEU A 592
MET A 666
GLY A 664
 None
 1.40A 1uhoA-2xsgA:
undetectable		 1uhoA-2xsgA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 HIS A  17
TYR A 184
LEU A 160
GLY A 129
PHE A 131
 None
 1.47A 1uhoA-2ywdA:
undetectable		 1uhoA-2ywdA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 612
HIS A 613
ALA A 783
PHE A 786
MET A 816
GLN A 817
GLY A 819
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 ( 4.1A)
VDN  A   1 (-3.6A)
 0.42A 1uhoA-3b2rA:
46.0		 1uhoA-3b2rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		5 HIS A  71
ALA A  66
PHE A  65
GLY A  56
PHE A  60
 GOL  A 146 (-4.0A)
None
None
None
None
 1.29A 1uhoA-3b8lA:
undetectable		 1uhoA-3b8lA:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 612
HIS A 613
ALA A 783
PHE A 786
GLN A 817
GLY A 819
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
 0.36A 1uhoA-3bjcA:
47.5		 1uhoA-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 612
HIS A 613
PHE A 786
MET A 816
GLN A 817
GLY A 819
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 (-4.8A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
 0.72A 1uhoA-3bjcA:
47.5		 1uhoA-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 617
GLN A 817
GLY A 819
PHE A 820
 None
ZN  A 876 (-3.3A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
 1.42A 1uhoA-3bjcA:
47.5		 1uhoA-3bjcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5n TUBBY-RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		5 TYR A 297
ALA A 476
PHE A 475
LEU A 273
GLY A 454
 None
 1.31A 1uhoA-3c5nA:
undetectable		 1uhoA-3c5nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN
METHYLAMINE
DEHYDROGENASE LIGHT
CHAIN

(Paracoccus
versutus) 		PF02975
(Me-amine-dh_L)
PF06433
(Me-amine-dh_H) 		5 TYR H 150
ALA H 170
LEU H 174
MET L 117
GLY L  79
 None
 1.37A 1uhoA-3c75H:
undetectable		 1uhoA-3c75H:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 325
HIS A 326
PHE A 506
GLN A 535
GLY A 537
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
None
D71  A 901 (-3.9A)
 0.51A 1uhoA-3g4gA:
36.0		 1uhoA-3g4gA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		5 TYR A 351
HIS A 299
LEU A 332
MET A 364
GLY A 366
 None
 1.43A 1uhoA-3iacA:
undetectable		 1uhoA-3iacA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 233
HIS A 234
PHE A 414
GLN A 443
GLY A 445
PHE A 446
 None
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.9A)
ZG2  A 506 (-3.6A)
 0.48A 1uhoA-3o57A:
36.2		 1uhoA-3o57A:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 ALA A  63
PHE A  97
LEU A  76
GLY A  44
PHE A  42
 None
 1.39A 1uhoA-3ps9A:
undetectable		 1uhoA-3ps9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 ALA A  63
PHE A  97
LEU A  76
GLY A  45
PHE A  42
 None
 1.40A 1uhoA-3ps9A:
undetectable		 1uhoA-3ps9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt7 HEMOGLOBIN II

(Phacoides
pectinatus) 		PF00042
(Globin) 		5 HIS A  97
PHE A  44
MET A  31
GLY A  28
PHE A  29
 HEM  A 500 (-3.4A)
HEM  A 500 (-4.0A)
None
None
None
 1.17A 1uhoA-3pt7A:
undetectable		 1uhoA-3pt7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		5 TYR A 221
HIS A 376
ALA A 369
MET A 346
GLN A 345
 None
 1.31A 1uhoA-3puaA:
undetectable		 1uhoA-3puaA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 159
HIS A 160
PHE A 340
GLN A 369
GLY A 371
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
GLY  A 371 ( 0.0A)
PHE  A 372 (-1.3A)
 0.37A 1uhoA-3sl5A:
36.4		 1uhoA-3sl5A:
28.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 524
HIS A 525
ALA A 689
GLY A 728
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
None
C1L  A   1 (-3.5A)
 1.27A 1uhoA-3ui7A:
41.3		 1uhoA-3ui7A:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 524
HIS A 525
PHE A 696
GLN A 726
GLY A 728
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-2.9A)
None
C1L  A   1 (-3.5A)
 0.44A 1uhoA-3ui7A:
41.3		 1uhoA-3ui7A:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 TYR A 551
ALA A 309
PHE A 376
GLN A 471
GLY A 504
 None
None
None
None
ANP  A2001 ( 3.9A)
 1.46A 1uhoA-3ummA:
undetectable		 1uhoA-3ummA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		5 TYR A 367
HIS A 368
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.41A 1uhoA-3v94A:
34.4		 1uhoA-3v94A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s AUTOPHAGY PROTEIN 5
UBIQUITIN-LIKE
PROTEIN ATG12

(Saccharomyces
cerevisiae) 		PF04106
(APG5)
PF04110
(APG12) 		5 ALA C 155
PHE C 154
GLN A 147
GLY A 275
PHE A 276
 None
 1.17A 1uhoA-3w1sC:
undetectable		 1uhoA-3w1sC:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		5 ALA A  75
LEU A  62
GLN A 486
GLY A 484
PHE A 483
 None
 1.22A 1uhoA-4b67A:
undetectable		 1uhoA-4b67A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		5 ALA A 265
PHE A  68
LEU A  77
GLY A  57
PHE A  48
 None
 1.40A 1uhoA-4blaA:
undetectable		 1uhoA-4blaA:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
HIS A 656
PHE A 830
GLN A 859
PHE A 862
 None
 0.21A 1uhoA-4htzA:
40.8		 1uhoA-4htzA:
35.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		6 TYR A 668
HIS A 669
PHE A 844
GLN A 874
GLY A 876
PHE A 877
 None
 0.70A 1uhoA-4i15A:
37.0		 1uhoA-4i15A:
31.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 TYR A 124
ALA A 158
PHE A 157
GLY A  25
PHE A  26
 None
 1.26A 1uhoA-4jypA:
undetectable		 1uhoA-4jypA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh CHAPERONE SYCD
COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ)
PF07720
(TPR_3) 		5 TYR A 228
ALA A 234
LEU B 157
GLY A 243
PHE A 239
 None
 1.48A 1uhoA-4nrhA:
undetectable		 1uhoA-4nrhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus) 		PF07992
(Pyr_redox_2) 		5 ALA A 291
PHE A 290
LEU A 316
GLY A 115
PHE A 103
 None
 1.44A 1uhoA-4ntcA:
undetectable		 1uhoA-4ntcA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 405
HIS A 406
PHE A 586
GLN A 615
GLY A 617
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
 0.42A 1uhoA-4wziA:
36.2		 1uhoA-4wziA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 222
HIS A 223
PHE A 392
GLN A 421
GLY A 423
PHE A 424
 None
4QJ  A 603 ( 4.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-4.2A)
4QJ  A 603 (-3.5A)
 0.65A 1uhoA-5b25A:
34.9		 1uhoA-5b25A:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 222
LEU A 409
GLN A 421
GLY A 423
PHE A 424
 None
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-4.2A)
4QJ  A 603 (-3.5A)
 0.91A 1uhoA-5b25A:
34.9		 1uhoA-5b25A:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 HIS A 104
ALA A 156
PHE A 122
GLY A 145
PHE A 160
 None
 1.22A 1uhoA-5cekA:
undetectable		 1uhoA-5cekA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGJ

(Escherichia
coli) 		PF02682
(CT_C_D) 		5 ALA B 160
LEU B 191
GLN B 133
GLY B 131
PHE B 136
 None
 1.04A 1uhoA-5dudB:
undetectable		 1uhoA-5dudB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 TYR C 327
ALA C 319
LEU C 361
GLY C 438
PHE C 439
 None
 0.96A 1uhoA-5g5gC:
undetectable		 1uhoA-5g5gC:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
HIS A 669
PHE A 845
GLN A 875
GLY A 877
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
None
LLN  A1003 (-3.8A)
 0.60A 1uhoA-5h2rA:
37.6		 1uhoA-5h2rA:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		5 TYR A 180
PHE A  92
LEU A  97
MET A 147
GLY A 192
 None
 1.33A 1uhoA-5huuA:
undetectable		 1uhoA-5huuA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izt OUTER SURFACE
PROTEIN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 TYR A 387
ALA A 385
LEU A 301
MET A 285
GLY A 282
 None
 1.07A 1uhoA-5iztA:
undetectable		 1uhoA-5iztA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		5 TYR A 287
ALA A 446
LEU A 439
MET A 322
PHE A 319
 None
 1.24A 1uhoA-5k9hA:
undetectable		 1uhoA-5k9hA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		5 ALA A 115
PHE A 118
LEU A 122
MET A  79
GLY A  76
 None
None
None
RBF  A 201 (-3.5A)
RBF  A 201 (-2.9A)
 1.50A 1uhoA-5kbwA:
undetectable		 1uhoA-5kbwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		5 ALA A 751
PHE A 752
MET A 709
GLY A 711
PHE A 707
 None
 1.38A 1uhoA-5kd5A:
undetectable		 1uhoA-5kd5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 6 TYR A 405
HIS A 406
PHE A 586
GLN A 615
GLY A 617
PHE A 618
 None
None
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
None
9VE  A 801 (-3.9A)
 0.34A 1uhoA-5ohjA:
36.4		 1uhoA-5ohjA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 TYR A 793
PHE A 823
MET A 754
GLN A 739
GLY A 742
 None
None
9E1  A1001 (-2.8A)
None
None
 1.47A 1uhoA-5vilA:
undetectable		 1uhoA-5vilA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viy BG1 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR H 165
HIS H 220
PHE H 166
LEU H  11
GLY H  94
 None
 1.44A 1uhoA-5viyH:
undetectable		 1uhoA-5viyH:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 6 TYR A 159
HIS A 160
PHE A 340
GLN A 369
GLY A 371
PHE A 372
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 (-4.5A)
AKJ  A 601 (-3.0A)
None
AKJ  A 601 (-4.1A)
 0.33A 1uhoA-5wh6A:
36.6		 1uhoA-5wh6A:
undetectable