SIMILAR PATTERNS OF AMINO ACIDS FOR 1UDU_B_CIAB2003_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdo ALCOHOL
DEHYDROGENASE

(Gadus morhua) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  71
ILE A  40
ILE A  91
VAL A 158
ALA A 157
 None
 1.02A 1uduB-1cdoA:
undetectable		 1uduB-1cdoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 ALA A 407
ILE A 406
ILE A 351
VAL A 347
ALA A 388
 None
 1.01A 1uduB-1d6mA:
undetectable		 1uduB-1d6mA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ALA A 644
GLN A 586
VAL A 589
PHE A 591
LEU A 606
 None
 1.05A 1uduB-1dedA:
undetectable		 1uduB-1dedA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2s SENSORY RHODOPSIN II
SENSORY RHODOPSIN II
TRANSDUCER

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin)
no annotation 		5 ALA A  12
ILE A  13
VAL A 198
ALA A 195
LEU B  32
 None
 1.07A 1uduB-1h2sA:
undetectable		 1uduB-1h2sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 ALA A  15
VAL A  32
ALA A  31
PHE A  57
PHE A  51
 None
 1.04A 1uduB-1ia5A:
undetectable		 1uduB-1ia5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ALA A 388
VAL A 295
ALA A 316
PHE A 319
LEU A 324
 None
 1.04A 1uduB-1iqrA:
undetectable		 1uduB-1iqrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01135
(PCMT) 		5 ALA A  87
ILE A  86
VAL A  39
PHE A  43
LEU A  28
 None
 1.09A 1uduB-1jg3A:
undetectable		 1uduB-1jg3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		5 ALA A 319
ILE A 318
VAL A 348
ALA A 349
PHE A 352
 ACR  A 700 (-3.2A)
None
None
None
None
 0.94A 1uduB-1lf9A:
undetectable		 1uduB-1lf9A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 0.94A 1uduB-1pk8A:
undetectable		 1uduB-1pk8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		5 ALA A 139
ILE A 236
VAL A 164
ALA A 165
PHE A 168
 None
 0.72A 1uduB-1t98A:
1.0		 1uduB-1t98A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		5 ALA A  43
ILE A  45
ILE A 136
ALA A 141
PHE A 144
 None
None
None
None
EDO  A 303 (-4.5A)
 1.06A 1uduB-1vq0A:
undetectable		 1uduB-1vq0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553

(Thermotoga
maritima) 		PF02424
(ApbE) 		5 ALA A 205
ILE A 204
ILE A 225
VAL A 216
LEU A  53
 None
MPD  A   1 ( 4.2A)
None
None
None
 0.98A 1uduB-1vrmA:
undetectable		 1uduB-1vrmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		5 TYR A  77
ALA A  94
ILE A  93
ILE A  75
ALA A  57
 None
 1.06A 1uduB-1wscA:
undetectable		 1uduB-1wscA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.73A 1uduB-1zklA:
34.2		 1uduB-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ALA A  21
ILE A  22
ILE A  54
ALA A  14
LEU A  12
 None
 0.91A 1uduB-2awaA:
undetectable		 1uduB-2awaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		5 ILE A 305
VAL A 228
ALA A 229
PHE A 232
LEU A 324
 None
 0.96A 1uduB-2bznA:
undetectable		 1uduB-2bznA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpe RNA-BINDING PROTEIN
EWS

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A 426
ILE A 363
VAL A 365
ALA A 413
PHE A 380
 None
 0.92A 1uduB-2cpeA:
undetectable		 1uduB-2cpeA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		5 TYR A 286
ILE A  26
ILE A   4
VAL A 282
ALA A 281
 None
 1.09A 1uduB-2e2nA:
undetectable		 1uduB-2e2nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Aquifex
aeolicus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A 318
ILE A 316
ILE A 242
ALA A 213
LEU A 223
 None
 1.02A 1uduB-2ep7A:
undetectable		 1uduB-2ep7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ful EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		5 ILE A 328
ALA A 385
PHE A 388
LEU A 392
MET A 362
 None
 1.09A 1uduB-2fulA:
undetectable		 1uduB-2fulA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 ALA A  22
ILE A  18
ILE A 141
VAL A 189
ALA A 150
 None
 1.10A 1uduB-2hmfA:
undetectable		 1uduB-2hmfA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ALA A 250
ILE A 254
VAL A  12
PHE A  44
MET A  41
 None
 1.10A 1uduB-2ho4A:
undetectable		 1uduB-2ho4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5i UPF0249 PROTEIN
EF_3048

(Enterococcus
faecalis) 		PF04794
(YdjC) 		5 ALA A  10
ILE A  23
VAL A  19
ALA A  18
MET A 229
 None
 1.01A 1uduB-2i5iA:
undetectable		 1uduB-2i5iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ALA X 398
ILE X 400
ALA X 436
LEU X  75
MET X  66
 None
 1.09A 1uduB-2iv2X:
undetectable		 1uduB-2iv2X:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ALA A 359
ILE A 358
ILE A 376
ALA A 336
LEU A 279
 None
 1.04A 1uduB-2iyoA:
undetectable		 1uduB-2iyoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l29 INSULIN-LIKE GROWTH
FACTOR 2 RECEPTOR
VARIANT

(Homo sapiens) 		PF00878
(CIMR) 		5 TYR A1606
GLN A1569
ILE A1572
VAL A1574
ALA A1565
 None
 1.02A 1uduB-2l29A:
undetectable		 1uduB-2l29A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5

(Arabidopsis
thaliana) 		PF00071
(Ras) 		5 ILE C 154
ILE C 113
ALA C  84
PHE C  85
LEU C  87
 None
 1.07A 1uduB-2ntyC:
undetectable		 1uduB-2ntyC:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF

(Bacillus
subtilis) 		PF00448
(SRP54) 		5 ILE A 173
ALA A 208
PHE A 209
LEU A 230
MET A 200
 None
 0.99A 1uduB-2px0A:
undetectable		 1uduB-2px0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ALA A 164
ILE A 134
VAL A 182
PHE A 220
LEU A 252
 None
 0.97A 1uduB-2qghA:
undetectable		 1uduB-2qghA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r15 MYOMESIN-1

(Homo sapiens) 		PF07679
(I-set) 		5 ILE A1633
ILE A1584
VAL A1582
LEU A1578
PHE A1631
 None
 1.07A 1uduB-2r15A:
undetectable		 1uduB-2r15A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.58A 1uduB-2r8qA:
37.0		 1uduB-2r8qA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ALA A 358
ILE A 357
ILE A 375
ALA A 335
LEU A 277
 None
 1.05A 1uduB-2w8zA:
undetectable		 1uduB-2w8zA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we5 CARBAMATE KINASE 1

(Enterococcus
faecalis) 		PF00696
(AA_kinase) 		5 ILE A 184
ILE A  46
VAL A   7
ALA A   8
LEU A 292
 None
 1.11A 1uduB-2we5A:
undetectable		 1uduB-2we5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 353
ILE A 354
ILE A 297
PHE A 266
LEU A 265
 None
None
None
KCX  A 262 ( 4.5A)
KCX  A 262 ( 4.4A)
 1.03A 1uduB-2wtzA:
undetectable		 1uduB-2wtzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y25 MYOMESIN

(Homo sapiens) 		PF07679
(I-set) 		5 ILE A1633
ILE A1584
VAL A1582
LEU A1578
PHE A1631
 None
 1.02A 1uduB-2y25A:
undetectable		 1uduB-2y25A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ALA A 357
ILE A 356
ILE A 374
ALA A 334
LEU A 277
 None
 1.05A 1uduB-2zygA:
undetectable		 1uduB-2zygA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1y ACIDIC RIBOSOMAL
PROTEIN P0

(Pyrococcus
horikoshii) 		PF00466
(Ribosomal_L10) 		5 ALA G 246
ILE G 243
VAL G 229
ALA G 228
PHE G 225
 None
 1.01A 1uduB-3a1yG:
undetectable		 1uduB-3a1yG:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		5 ALA A 453
ILE A 456
ILE A 423
VAL A 176
ALA A 170
 None
 1.04A 1uduB-3al0A:
undetectable		 1uduB-3al0A:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
ALA A 783
PHE A 786
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.4A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.60A 1uduB-3b2rA:
43.4		 1uduB-3b2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
ALA A 783
PHE A 786
MET A 816
GLN A 817
PHE A 820
 None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.6A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.63A 1uduB-3bjcA:
44.7		 1uduB-3bjcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		6 ALA A 641
GLN A 583
ILE A 584
VAL A 586
PHE A 588
LEU A 603
 None
 1.16A 1uduB-3bmwA:
undetectable		 1uduB-3bmwA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		5 ALA A 137
ILE A 138
ALA A  99
LEU A  72
PHE A 106
 None
 1.09A 1uduB-3c1oA:
undetectable		 1uduB-3c1oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3q TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Staphylococcus
epidermidis) 		PF01715
(IPPT) 		5 ILE A  12
VAL A  27
ALA A  28
PHE A  31
PHE A   8
 None
 1.09A 1uduB-3d3qA:
undetectable		 1uduB-3d3qA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebj POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
 1.00A 1uduB-3ebjA:
undetectable		 1uduB-3ebjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		5 ALA A 132
ILE A 229
ILE A  94
VAL A  92
ALA A 198
 None
 1.06A 1uduB-3eeiA:
undetectable		 1uduB-3eeiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehc SNOAL-LIKE
POLYKETIDE CYCLASE

(Agrobacterium
fabrum) 		PF07366
(SnoaL) 		5 ALA A 121
ILE A 122
GLN A 125
LEU A  57
PHE A  85
 None
 0.99A 1uduB-3ehcA:
undetectable		 1uduB-3ehcA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C) 		5 ALA A 139
ILE A 236
VAL A 164
ALA A 165
PHE A 168
 None
 0.73A 1uduB-3euhA:
undetectable		 1uduB-3euhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 TYR A 141
ILE A  73
VAL A 137
MET A  99
PHE A 101
 None
 1.10A 1uduB-3g7uA:
undetectable		 1uduB-3g7uA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grf ORNITHINE
CARBAMOYLTRANSFERASE

(Giardia
intestinalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A  14
ILE A  12
VAL A 316
ALA A 315
MET A 142
 None
 1.09A 1uduB-3grfA:
undetectable		 1uduB-3grfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 ALA A 180
ILE A 181
ILE A 488
ALA A 428
LEU A 299
 None
 0.98A 1uduB-3hq2A:
undetectable		 1uduB-3hq2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 ALA A 397
ILE A 394
ILE A 291
PHE A 256
GLN A 293
 None
 1.03A 1uduB-3i04A:
undetectable		 1uduB-3i04A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		5 ILE A 263
ILE A 169
VAL A 165
ALA A 164
PHE A 161
 None
 1.02A 1uduB-3kcuA:
undetectable		 1uduB-3kcuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN BETA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		5 ALA B 138
ILE B 139
ILE B  44
VAL B  93
ALA B  96
 None
 1.10A 1uduB-3kvsB:
undetectable		 1uduB-3kvsB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 ILE A 434
GLN A 430
ILE A 403
VAL A 399
ALA A 448
 None
 1.01A 1uduB-3pc3A:
undetectable		 1uduB-3pc3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 ALA A 137
ILE A 138
ILE A 241
VAL A 285
ALA A 286
 None
 1.09A 1uduB-3qfhA:
undetectable		 1uduB-3qfhA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		5 ILE A 145
VAL A 149
ALA A 150
PHE A 153
LEU A 160
 None
 0.73A 1uduB-3rjyA:
undetectable		 1uduB-3rjyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		5 ALA A 327
VAL A 311
ALA A 310
PHE A 312
LEU A  19
 None
 1.00A 1uduB-3rp7A:
undetectable		 1uduB-3rp7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		5 ALA A  69
ILE A  26
VAL A  98
ALA A  99
PHE A 102
 None
None
IOD  A 352 ( 4.1A)
None
None
 1.00A 1uduB-3s99A:
undetectable		 1uduB-3s99A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		5 ILE A 111
ILE A 180
VAL A 184
PHE A 188
LEU A  86
 None
 1.00A 1uduB-3tqrA:
undetectable		 1uduB-3tqrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		5 TYR A 367
ALA A 524
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.59A 1uduB-3v94A:
33.5		 1uduB-3v94A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		5 ALA A 226
ILE A 227
ILE A 110
VAL A 115
LEU A 172
 None
 0.82A 1uduB-3vvaA:
undetectable		 1uduB-3vvaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 TYR A 213
ALA A  36
VAL A 209
ALA A 208
LEU A 201
 None
 1.01A 1uduB-4a9aA:
undetectable		 1uduB-4a9aA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 ALA A  66
ILE A  69
ILE A 243
VAL A 247
LEU A 506
 None
 1.07A 1uduB-4ainA:
undetectable		 1uduB-4ainA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cd8 ENDO-BETA-1,4-MANNAN
ASE

(Alicyclobacillus
acidocaldarius) 		no annotation 5 TYR A 262
VAL A 310
ALA A 311
PHE A 314
GLN A  42
 None
 0.78A 1uduB-4cd8A:
undetectable		 1uduB-4cd8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ILE A 664
ILE A 678
VAL A 676
PHE A 674
LEU A 631
 None
 1.05A 1uduB-4d8mA:
undetectable		 1uduB-4d8mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esj TYPE-2 RESTRICTION
ENZYME DPNI

(Streptococcus
pneumoniae) 		PF06044
(DpnI) 		5 ILE A 236
GLN A 233
ILE A 192
PHE A 117
PHE A 177
 None
 1.10A 1uduB-4esjA:
undetectable		 1uduB-4esjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 181
ILE A 222
ILE A 182
LEU A 135
PHE A 189
 None
 1.09A 1uduB-4gisA:
undetectable		 1uduB-4gisA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
ILE A 822
PHE A 830
GLN A 859
PHE A 862
 None
 0.68A 1uduB-4htzA:
39.1		 1uduB-4htzA:
35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 ALA A 645
GLN A 587
VAL A 590
PHE A 592
LEU A 607
 None
 1.09A 1uduB-4jclA:
undetectable		 1uduB-4jclA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5o POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
None
X48  A 306 ( 4.9A)
None
None
 0.97A 1uduB-4m5oA:
undetectable		 1uduB-4m5oA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfz POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
 0.90A 1uduB-4nfzA:
undetectable		 1uduB-4nfzA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 ALA A 327
ILE A 330
ILE A 255
VAL A 153
ALA A 251
 None
 1.07A 1uduB-4npaA:
undetectable		 1uduB-4npaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx9 FLAGELLIN

(Pseudomonas
aeruginosa) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		5 ILE A  71
ILE A 156
VAL A 158
ALA A 144
LEU A 136
 None
 0.96A 1uduB-4nx9A:
undetectable		 1uduB-4nx9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onr DECORIN-BINDING
PROTEIN DBPA

(Borreliella
burgdorferi) 		PF02352
(Decorin_bind) 		5 ILE A  96
ILE A 156
VAL A 138
LEU A 126
PHE A  92
 None
 0.96A 1uduB-4onrA:
undetectable		 1uduB-4onrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		5 ALA A  79
ILE A  39
VAL A 108
ALA A 109
PHE A 112
 None
 1.07A 1uduB-4p98A:
undetectable		 1uduB-4p98A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		5 ILE A 456
ILE A 341
ALA A 284
PHE A 285
LEU A 527
 None
 1.07A 1uduB-4r12A:
undetectable		 1uduB-4r12A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A 317
ILE A 182
VAL A 184
ALA A 197
LEU A 162
 None
 1.03A 1uduB-4r70A:
undetectable		 1uduB-4r70A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		5 ALA A 210
ILE A 159
VAL A 161
ALA A 222
PHE A 227
 None
 1.00A 1uduB-4ry8A:
undetectable		 1uduB-4ry8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 ALA A 190
ILE A 194
GLN A 309
ILE A 174
LEU A 239
 None
 1.01A 1uduB-4u1rA:
undetectable		 1uduB-4u1rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		5 ALA A 290
ILE A 291
ILE A 283
ALA A 342
PHE A 320
 None
 0.99A 1uduB-4uz1A:
undetectable		 1uduB-4uz1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE

(Sphingobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 ALA A 285
ILE A 286
ILE A 266
VAL A 268
ALA A 243
 None
 1.03A 1uduB-4wdrA:
undetectable		 1uduB-4wdrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yb9 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Bos taurus) 		PF00083
(Sugar_tr) 		5 ILE D 172
VAL D 176
ALA D 177
PHE D 180
LEU D 198
 None
 0.92A 1uduB-4yb9D:
undetectable		 1uduB-4yb9D:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ALA A 309
ILE A 244
ALA A 286
LEU A 275
PHE A 267
 None
 1.10A 1uduB-5a3yA:
undetectable		 1uduB-5a3yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 222
PHE A 392
LEU A 409
GLN A 421
PHE A 424
 None
GOL  A 607 (-3.9A)
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 1.01A 1uduB-5b25A:
33.9		 1uduB-5b25A:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		6 ALA A 182
ILE A 181
ILE A 183
VAL A 161
ALA A 158
LEU A 268
 None
 1.29A 1uduB-5b58A:
undetectable		 1uduB-5b58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		5 ALA A 148
ILE A 179
ILE A 135
VAL A 160
ALA A 159
 None
 1.09A 1uduB-5b7sA:
undetectable		 1uduB-5b7sA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 ALA E 199
GLN E 187
ILE E 177
PHE E 213
GLN E 184
 None
 1.08A 1uduB-5e24E:
undetectable		 1uduB-5e24E:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ILE A1717
ILE A1956
VAL A1979
ALA A1978
PHE A1827
 None
 0.93A 1uduB-5fbyA:
undetectable		 1uduB-5fbyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffq SHUY-LIKE PROTEIN

(Escherichia
coli) 		PF13460
(NAD_binding_10) 		5 ALA A  71
ILE A  98
VAL A  30
ALA A  31
PHE A  50
 None
 1.08A 1uduB-5ffqA:
undetectable		 1uduB-5ffqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		5 GLN A 290
ALA A 229
PHE A 227
LEU A 239
GLN A 232
 None
 1.01A 1uduB-5fprA:
undetectable		 1uduB-5fprA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 5 TYR A 668
VAL A 841
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.68A 1uduB-5h2rA:
36.7		 1uduB-5h2rA:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		5 ILE A 166
VAL A 170
ALA A 171
PHE A 174
LEU A 181
 None
 0.68A 1uduB-5h4rA:
undetectable		 1uduB-5h4rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 ALA A 140
ILE A 143
ILE A 176
VAL A 180
ALA A 181
 None
 0.95A 1uduB-5hn4A:
undetectable		 1uduB-5hn4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ALA A 257
ILE A 262
ALA A 242
LEU A 208
PHE A 120
 None
 1.05A 1uduB-5isoA:
undetectable		 1uduB-5isoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ALA A 466
ALA A 457
PHE A 193
LEU A 487
PHE A 483
 None
 1.08A 1uduB-5nd1A:
undetectable		 1uduB-5nd1A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A  53
ILE A  13
VAL A  17
ALA A  18
PHE A  21
 1PE  A1001 ( 3.8A)
None
None
None
None
 0.88A 1uduB-5oqpA:
undetectable		 1uduB-5oqpA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ALA A 177
ILE A 178
ILE A 153
LEU A  63
GLN A 369
 None
 0.92A 1uduB-5w4bA:
undetectable		 1uduB-5w4bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysq TM0415

(Thermotoga
maritima) 		no annotation 5 ALA A  31
ILE A  32
VAL A  65
PHE A  67
PHE A  57
 None
 1.07A 1uduB-5ysqA:
undetectable		 1uduB-5ysqA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9a CHORISMATE SYNTHASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 327
ILE A 330
ILE A 206
VAL A 208
ALA A 287
 None
 1.02A 1uduB-5z9aA:
undetectable		 1uduB-5z9aA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 5 ALA A 221
ILE A 220
ILE A 189
LEU A 313
MET A 200
 UDP  A 401 ( 4.0A)
None
None
None
None
 0.86A 1uduB-6ejjA:
undetectable		 1uduB-6ejjA:
12.46