SIMILAR PATTERNS OF AMINO ACIDS FOR 1UDU_A_CIAA1003

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus)
PF02078
(Synapsin)
PF02750
(Synapsin_C)
5 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
None
0.96A 1uduA-1auxA:
undetectable
1uduA-1auxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE


(Pseudomonas sp.
7A)
PF00710
(Asparaginase)
5 SER A1220
VAL A1113
LEU A1221
ILE A1315
MET A1318
None
1.24A 1uduA-1djpA:
undetectable
1uduA-1djpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF01012
(ETF)
5 TYR B 211
ILE B 104
VAL B 108
ALA B 109
ILE B 117
None
1.08A 1uduA-1efpB:
undetectable
1uduA-1efpB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 165
VAL A 167
PHE A 169
LEU A  38
ILE A  50
None
1.17A 1uduA-1fnoA:
undetectable
1uduA-1fnoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ifv PROTEIN LLR18B

(Lupinus luteus)
PF00407
(Bet_v_1)
5 ILE A 115
VAL A 117
ALA A   4
PHE A 119
LEU A 126
None
1.19A 1uduA-1ifvA:
undetectable
1uduA-1ifvA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli)
PF00463
(ICL)
5 TYR A 282
SER A  28
ILE A 210
VAL A 214
ALA A 215
None
1.00A 1uduA-1igwA:
undetectable
1uduA-1igwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 SER A 324
ILE A 421
ALA A 372
LEU A 304
ILE A 370
None
1.13A 1uduA-1jscA:
undetectable
1uduA-1jscA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE


(Escherichia
coli)
PF00815
(Histidinol_dh)
5 SER A  69
VAL A 178
ALA A 173
ILE A 169
PHE A 182
None
1.19A 1uduA-1kaeA:
undetectable
1uduA-1kaeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 SER B 446
ALA B 323
LEU B 321
ILE B 537
PHE B 544
None
1.13A 1uduA-1m2vB:
0.8
1uduA-1m2vB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3s HYPOTHETICAL PROTEIN
YCKF


(Bacillus
subtilis)
PF01380
(SIS)
5 ILE A  84
ALA A  51
PHE A  54
LEU A  58
ILE A  67
None
1.10A 1uduA-1m3sA:
undetectable
1uduA-1m3sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbb CYTOCHROME C'

(Rhodobacter
capsulatus)
PF01322
(Cytochrom_C_2)
5 TYR A  13
VAL A  51
ALA A  52
PHE A  55
MET A  78
NBN  A 131 ( 4.3A)
NBN  A 131 (-4.3A)
None
HEM  A 130 ( 4.9A)
None
1.28A 1uduA-1nbbA:
0.6
1uduA-1nbbA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqv TOXIN-COREGULATED
PILUS SUBUNIT


(Vibrio cholerae)
PF05946
(TcpA)
5 VAL A 194
ALA A 195
PHE A 196
LEU A  40
PHE A  88
None
1.24A 1uduA-1oqvA:
undetectable
1uduA-1oqvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 SER A 446
ALA A 323
LEU A 321
ILE A 537
PHE A 544
None
1.23A 1uduA-1pd1A:
undetectable
1uduA-1pd1A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus)
PF02078
(Synapsin)
PF02750
(Synapsin_C)
5 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
None
0.95A 1uduA-1pk8A:
undetectable
1uduA-1pk8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE


(Spinacia
oleracea)
PF00316
(FBPase)
5 SER A  46
ALA A 105
PHE A  91
LEU A  95
ILE A 103
None
1.11A 1uduA-1spiA:
undetectable
1uduA-1spiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1veu MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1 INTERACTING
PROTEIN 1


(Mus musculus)
PF08923
(MAPKK1_Int)
5 SER A  15
VAL A  35
ALA A  36
LEU A  19
ILE A  93
None
1.29A 1uduA-1veuA:
undetectable
1uduA-1veuA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))


(Thermotoga
maritima)
PF00923
(TAL_FSA)
5 ILE A 160
ALA A 174
ILE A 165
MET A 184
PHE A   4
GOL  A 219 ( 4.7A)
None
None
None
None
1.22A 1uduA-1vpxA:
undetectable
1uduA-1vpxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli)
PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C)
5 ILE A  88
ALA A   7
PHE A  82
LEU A  19
ILE A  29
None
1.29A 1uduA-1z7eA:
undetectable
1uduA-1z7eA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
7 TYR A 211
VAL A 380
PHE A 384
LEU A 401
ILE A 409
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.88A 1uduA-1zklA:
34.1
1uduA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ful EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5


(Saccharomyces
cerevisiae)
PF02020
(W2)
5 ILE A 328
ALA A 385
PHE A 388
LEU A 392
MET A 362
None
1.10A 1uduA-2fulA:
undetectable
1uduA-2fulA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
PF01937
(DUF89)
5 ILE A 105
VAL A 101
ALA A 100
PHE A  97
ILE A 166
None
1.10A 1uduA-2g8lA:
undetectable
1uduA-2g8lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3b HUMAN CANCER-RELATED
NTPASE


(Homo sapiens)
PF03266
(NTPase_1)
5 ILE A 138
VAL A   4
PHE A 166
LEU A 176
ILE A  18
None
1.17A 1uduA-2i3bA:
undetectable
1uduA-2i3bA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o34 HYPOTHETICAL PROTEIN

(Desulfovibrio
vulgaris)
no annotation 5 ILE A 108
VAL A 112
ALA A 113
PHE A 116
LEU A  44
None
1.25A 1uduA-2o34A:
undetectable
1uduA-2o34A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae)
PF00710
(Asparaginase)
5 VAL A 205
PHE A 105
LEU A 101
ILE A 208
GLN A  69
None
1.06A 1uduA-2ocdA:
undetectable
1uduA-2ocdA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN


(Shigella
dysenteriae)
PF01497
(Peripla_BP_2)
5 SER A  54
ILE A  26
VAL A  28
ALA A  29
ILE A  65
None
1.26A 1uduA-2r7aA:
undetectable
1uduA-2r7aA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1


(Leishmania
major)
PF00233
(PDEase_I)
5 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
0.58A 1uduA-2r8qA:
37.0
1uduA-2r8qA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 TYR A 554
SER A 636
VAL A 552
PHE A 621
LEU A 648
None
1.19A 1uduA-2wanA:
undetectable
1uduA-2wanA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2


(Mus musculus)
PF00054
(Laminin_G_1)
5 ILE A2635
VAL A2633
PHE A2631
LEU A2595
ILE A2546
None
1.28A 1uduA-2wjsA:
undetectable
1uduA-2wjsA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1


(Homo sapiens)
PF01026
(TatD_DNase)
5 SER A 214
VAL A 273
ALA A 272
LEU A 281
PHE A 195
None
1.12A 1uduA-2xioA:
undetectable
1uduA-2xioA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y25 MYOMESIN

(Homo sapiens)
PF07679
(I-set)
5 SER A1657
ILE A1584
VAL A1582
LEU A1578
PHE A1631
None
1.24A 1uduA-2y25A:
undetectable
1uduA-2y25A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE


(Shewanella sp.
AP1)
PF00245
(Alk_phosphatase)
5 SER A 276
ILE A 191
ALA A 229
LEU A 275
ILE A 226
None
1.29A 1uduA-3a52A:
undetectable
1uduA-3a52A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
9 TYR A 612
ILE A 778
VAL A 782
ALA A 783
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.74A 1uduA-3b2rA:
43.4
1uduA-3b2rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 SER X 479
VAL X 206
ALA X 207
LEU X 480
ILE X 466
None
1.19A 1uduA-3b8aX:
undetectable
1uduA-3b8aX:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
9 TYR A 612
ILE A 778
VAL A 782
ALA A 783
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
None
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.65A 1uduA-3bjcA:
44.6
1uduA-3bjcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctm CARBONYL REDUCTASE

(Candida
parapsilosis)
PF13561
(adh_short_C2)
5 TYR A 254
ILE A  46
VAL A  50
ALA A  51
ILE A  63
None
1.01A 1uduA-3ctmA:
undetectable
1uduA-3ctmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d89 RIESKE
DOMAIN-CONTAINING
PROTEIN


(Mus musculus)
PF13806
(Rieske_2)
5 ILE A  55
VAL A  42
ALA A  52
LEU A  89
ILE A 119
None
1.23A 1uduA-3d89A:
undetectable
1uduA-3d89A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d89 RIESKE
DOMAIN-CONTAINING
PROTEIN


(Mus musculus)
PF13806
(Rieske_2)
5 VAL A  42
ALA A  52
PHE A  44
LEU A  89
ILE A 119
None
1.27A 1uduA-3d89A:
undetectable
1uduA-3d89A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica)
PF13614
(AAA_31)
5 SER A 316
ILE A 393
VAL A 389
ALA A 388
PHE A 385
None
1.24A 1uduA-3ez9A:
undetectable
1uduA-3ez9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6


(Homo sapiens)
PF00531
(Death)
5 TYR A 232
ILE A 236
VAL B 103
ALA B 100
LEU B 165
None
1.23A 1uduA-3ezqA:
undetectable
1uduA-3ezqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6m 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Yersinia pestis)
PF02542
(YgbB)
5 ILE A 148
VAL A  41
ALA A  42
ILE A  98
PHE A   7
None
1.19A 1uduA-3f6mA:
undetectable
1uduA-3f6mA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
5 SER A1678
ILE A1386
ALA A1393
ILE A1400
PHE A 992
None
1.28A 1uduA-3hmjA:
undetectable
1uduA-3hmjA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE


(Cupriavidus
pinatubonensis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 TYR A 196
ILE A 238
ALA A 184
LEU A 264
ILE A 180
BCN  A 301 (-4.5A)
None
None
None
None
1.12A 1uduA-3hwrA:
undetectable
1uduA-3hwrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
5 TYR A 262
ILE A  56
VAL A  60
PHE A  64
ILE A  73
None
NAE  A 311 (-3.8A)
None
None
None
1.21A 1uduA-3i3oA:
undetectable
1uduA-3i3oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilr HEPARIN LYASE I

(Bacteroides
thetaiotaomicron)
PF14099
(Polysacc_lyase)
5 TYR A  90
ILE A  31
VAL A  37
ALA A  38
ILE A  47
None
1.28A 1uduA-3ilrA:
undetectable
1uduA-3ilrA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE


(Cricetulus
griseus)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
5 VAL A  60
ALA A  61
PHE A  62
LEU A  72
ILE A  74
None
1.28A 1uduA-3j97A:
undetectable
1uduA-3j97A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kly PUTATIVE FORMATE
TRANSPORTER 1


(Vibrio cholerae)
PF01226
(Form_Nir_trans)
5 ILE A 238
ALA A 226
PHE A 225
LEU A 132
MET A 218
None
1.16A 1uduA-3klyA:
undetectable
1uduA-3klyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv1 TRANSCRIPTIONAL
REPRESSOR


(Aliivibrio
fischeri)
PF04198
(Sugar-bind)
5 SER A  44
ILE A 243
VAL A 245
ALA A  22
ILE A  24
GOL  A 284 (-3.2A)
None
None
None
None
1.17A 1uduA-3kv1A:
undetectable
1uduA-3kv1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw0 CYSTEINE PEPTIDASE

(Bacillus cereus)
PF05708
(Peptidase_C92)
5 TYR A  14
SER A  93
ILE A  18
ILE A 191
PHE A  27
None
1.08A 1uduA-3kw0A:
undetectable
1uduA-3kw0A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis)
PF00463
(ICL)
5 TYR A 283
SER A  29
ILE A 211
VAL A 215
ALA A 216
None
1.03A 1uduA-3lg3A:
undetectable
1uduA-3lg3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE


(Pseudoalteromonas
haloplanktis)
PF00756
(Esterase)
5 SER A 264
ILE A 143
ALA A 169
PHE A 170
PHE A  61
None
1.26A 1uduA-3ls2A:
undetectable
1uduA-3ls2A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME


([Candida]
glabrata)
PF02110
(HK)
PF02581
(TMP-TENI)
5 ILE A 472
VAL A 493
LEU A 537
ILE A 253
PHE A 486
None
1.08A 1uduA-3nm1A:
undetectable
1uduA-3nm1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ors N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE


(Staphylococcus
aureus)
PF00731
(AIRC)
5 VAL A  81
ALA A  74
LEU A  69
MET A  44
PHE A  47
None
1.20A 1uduA-3orsA:
undetectable
1uduA-3orsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1


(Bacillus
halodurans)
PF00171
(Aldedh)
5 VAL A 422
ALA A 423
PHE A 424
LEU A 337
MET A 385
None
1.27A 1uduA-3qanA:
undetectable
1uduA-3qanA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli)
PF00905
(Transpeptidase)
5 SER A 172
ILE A 112
VAL A 188
LEU A 178
ILE A  76
EDO  A  10 (-2.7A)
None
None
None
None
1.23A 1uduA-3qnbA:
undetectable
1uduA-3qnbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica)
PF13561
(adh_short_C2)
5 TYR A 269
ILE A  61
ALA A  66
LEU A  53
ILE A  78
None
NAD  A 300 (-3.7A)
None
None
None
1.08A 1uduA-3r3sA:
undetectable
1uduA-3r3sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A


(Fervidobacterium
nodosum)
PF00150
(Cellulase)
5 ILE A 145
VAL A 149
ALA A 150
PHE A 153
LEU A 160
None
0.73A 1uduA-3rjyA:
undetectable
1uduA-3rjyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr0 GUANYLATE KINASE

(Coxiella
burnetii)
PF00625
(Guanylate_kin)
5 ILE A 178
VAL A 174
ALA A 173
PHE A 170
ILE A 121
None
0.99A 1uduA-3tr0A:
undetectable
1uduA-3tr0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR


(Caldanaerobacter
subterraneus)
PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
5 SER A 670
ILE A 559
ALA A 606
ILE A 551
PHE A 600
None
1.25A 1uduA-3vthA:
undetectable
1uduA-3vthA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE


(Aquifex
aeolicus)
PF03841
(SelA)
5 SER A 250
ILE A 302
VAL A 296
PHE A 268
ILE A 276
None
1.18A 1uduA-3w1jA:
undetectable
1uduA-3w1jA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)


(Bacteroides
ovatus)
PF00150
(Cellulase)
PF13004
(BACON)
5 ILE A 250
ALA A 293
PHE A 292
LEU A 290
ILE A 247
None
1.16A 1uduA-3zmrA:
undetectable
1uduA-3zmrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN


([Clostridium]
clariflavum)
PF00942
(CBM_3)
5 VAL A  57
ALA A  56
PHE A  55
LEU A  86
PHE A  25
None
1.21A 1uduA-4b96A:
undetectable
1uduA-4b96A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxi ACCESSORY GENE
REGULATOR PROTEIN C


(Staphylococcus
aureus)
PF14501
(HATPase_c_5)
5 ILE A 311
VAL A 354
ALA A 355
PHE A 365
ILE A 315
None
1.29A 1uduA-4bxiA:
undetectable
1uduA-4bxiA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cd8 ENDO-BETA-1,4-MANNAN
ASE


(Alicyclobacillus
acidocaldarius)
no annotation 5 TYR A 262
VAL A 310
ALA A 311
PHE A 314
GLN A  42
None
0.80A 1uduA-4cd8A:
undetectable
1uduA-4cd8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1


(Mytilus
galloprovincialis)
PF00092
(VWA)
5 ILE A 407
VAL A 416
ALA A 394
LEU A 435
ILE A 392
None
1.21A 1uduA-4cn8A:
undetectable
1uduA-4cn8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 ILE A 564
ALA A 555
PHE A 557
ILE A 551
MET A 549
None
1.26A 1uduA-4dpgA:
undetectable
1uduA-4dpgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF


(Escherichia
coli)
PF01656
(CbiA)
5 ALA A 161
PHE A 162
LEU A 197
ILE A 137
PHE A   6
None
1.19A 1uduA-4e09A:
undetectable
1uduA-4e09A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN


(Escherichia
coli)
PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn)
5 ILE A 229
VAL A  37
ALA A 214
LEU A 185
PHE A  29
None
1.22A 1uduA-4finA:
undetectable
1uduA-4finA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
6 TYR A 655
ILE A 822
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.68A 1uduA-4htzA:
39.1
1uduA-4htzA:
35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6e MRNA-DECAPPING
ENZYME SUBUNIT 2


(Saccharomyces
cerevisiae)
PF00293
(NUDIX)
5 ALA A 108
PHE A 131
LEU A 120
ILE A 110
PHE A 207
None
1.06A 1uduA-4k6eA:
undetectable
1uduA-4k6eA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4khb UNCHARACTERIZED
PROTEIN POB3N


(Chaetomium
thermophilum)
no annotation 5 ILE D 145
VAL D 147
PHE D 149
LEU D 175
PHE D 127
None
1.25A 1uduA-4khbD:
undetectable
1uduA-4khbD:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 SER A 433
ILE A 518
ALA A 521
LEU A 432
MET A 458
None
None
PZW  A 801 ( 4.6A)
None
PZW  A 801 (-4.4A)
1.13A 1uduA-4q9zA:
undetectable
1uduA-4q9zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis)
PF13561
(adh_short_C2)
5 ILE A  15
VAL A  19
ALA A  20
PHE A  23
ILE A  32
NAP  A 300 (-3.7A)
None
None
None
None
0.63A 1uduA-4qedA:
undetectable
1uduA-4qedA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2


(Mus musculus)
PF13855
(LRR_8)
5 TYR B 138
ILE B 164
VAL B 162
ILE B 208
MET B 209
None
0.97A 1uduA-4y61B:
undetectable
1uduA-4y61B:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yb9 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5


(Bos taurus)
PF00083
(Sugar_tr)
5 ILE D 172
VAL D 176
ALA D 177
PHE D 180
LEU D 198
None
0.91A 1uduA-4yb9D:
undetectable
1uduA-4yb9D:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye2 CAPPING ENZYME
PROTEIN


(Rotavirus A)
PF05213
(Corona_NS2A)
5 ILE A 798
VAL A 767
LEU A 771
ILE A 795
PHE A 721
None
None
None
A2P  A 901 (-3.9A)
None
1.28A 1uduA-4ye2A:
undetectable
1uduA-4ye2A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
5 SER A 891
ILE A 122
VAL A 126
LEU A 892
MET A 833
None
1.26A 1uduA-5a22A:
undetectable
1uduA-5a22A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B


(Homo sapiens)
PF00233
(PDEase_I)
5 TYR A 222
PHE A 392
LEU A 409
GLN A 421
PHE A 424
None
GOL  A 607 (-3.9A)
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
1.05A 1uduA-5b25A:
33.8
1uduA-5b25A:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpt PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY M MEMBER 1,
GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE
1,GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE 1


(Homo sapiens)
PF02991
(Atg8)
5 ILE A  39
VAL A 114
ALA A 115
PHE A  85
LEU A  83
None
1.18A 1uduA-5dptA:
undetectable
1uduA-5dptA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esz 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160


(Haemophilus
influenzae;
Human
immunodeficiency
virus 1)
PF00516
(GP120)
PF02542
(YgbB)
5 ILE C 305
VAL C 204
ALA C 205
ILE C 255
PHE C 119
None
1.16A 1uduA-5eszC:
undetectable
1uduA-5eszC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN


(Streptomyces
lividans)
PF03067
(LPMO_10)
5 SER A 172
VAL A 199
PHE A 201
LEU A 174
PHE A 150
None
1.18A 1uduA-5ftzA:
undetectable
1uduA-5ftzA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai)
no annotation 5 SER A 149
ILE A 158
VAL A 157
ILE A 143
GLN A 165
None
1.20A 1uduA-5gmtA:
undetectable
1uduA-5gmtA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN


(Pedobacter
heparinus)
PF16265
(DUF4918)
5 TYR A  46
SER A  55
VAL A   8
PHE A   4
GLN A 165
None
1.21A 1uduA-5h0kA:
undetectable
1uduA-5h0kA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei)
no annotation 5 TYR A 668
VAL A 841
PHE A 845
GLN A 875
PHE A 878
LLN  A1003 ( 4.8A)
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
0.70A 1uduA-5h2rA:
36.7
1uduA-5h2rA:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE


(Caldicellulosiruptor
sp. F32)
PF00150
(Cellulase)
5 ILE A 166
VAL A 170
ALA A 171
PHE A 174
LEU A 181
None
0.67A 1uduA-5h4rA:
undetectable
1uduA-5h4rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 SER A  60
ILE A  30
VAL A  32
ALA A  33
ILE A  35
None
1.21A 1uduA-5ip9A:
undetectable
1uduA-5ip9A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3


(Homo sapiens)
PF03850
(Tfb4)
5 SER 3  35
ILE 3  60
VAL 3  15
LEU 3  34
MET 3 119
None
1.28A 1uduA-5ivw3:
undetectable
1uduA-5ivw3:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Paraburkholderia
xenovorans)
PF13561
(adh_short_C2)
5 ILE A  18
VAL A  22
ALA A  23
PHE A  26
ILE A  35
NAD  A 301 (-3.8A)
None
None
None
None
0.77A 1uduA-5jy1A:
undetectable
1uduA-5jy1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
5 TYR A 289
ILE A  81
ALA A  86
LEU A  73
ILE A  98
None
NAD  A 901 (-3.8A)
None
None
None
1.16A 1uduA-5jydA:
undetectable
1uduA-5jydA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
5 TYR A 289
ILE A  81
ALA A  86
PHE A  89
ILE A  98
None
NAD  A 901 (-3.8A)
None
None
None
1.09A 1uduA-5jydA:
undetectable
1uduA-5jydA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB


(Klebsiella
pneumoniae)
PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C)
5 SER A  23
ILE A 192
VAL A  32
ALA A 207
ILE A 209
None
None
PT  A 301 (-4.9A)
None
None
1.20A 1uduA-5l75A:
undetectable
1uduA-5l75A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC


(Pseudomonas
protegens)
no annotation 5 SER C 274
ILE C 377
VAL C 379
ALA C 295
ILE C 313
None
1.16A 1uduA-5mg5C:
undetectable
1uduA-5mg5C:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN


(Agrobacterium
tumefaciens)
no annotation 5 SER A 193
VAL A 115
ALA A 114
ILE A 210
MET A 215
None
1.14A 1uduA-5oreA:
undetectable
1uduA-5oreA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens)
no annotation 5 TYR B 233
ILE B 236
ALA B 277
ILE B 249
PHE A 136
None
1.21A 1uduA-5u7zB:
undetectable
1uduA-5u7zB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa0 PUTATIVE SULFITE
OXIDASE


(Sinorhizobium
meliloti)
no annotation 6 SER A 290
VAL A 124
ALA A 344
PHE A 311
ILE A  68
PHE A  64
None
1.17A 1uduA-5wa0A:
undetectable
1uduA-5wa0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x68 KYNURENINE
3-MONOOXYGENASE


(Homo sapiens)
no annotation 5 ILE A 215
ALA A 225
LEU A 197
ILE A 199
PHE A 261
None
1.27A 1uduA-5x68A:
undetectable
1uduA-5x68A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE


(Salmonella
enterica)
no annotation 5 SER A 348
ILE A 261
VAL A 263
LEU A 297
PHE A 242
LLP  A  78 ( 4.4A)
None
None
None
None
1.22A 1uduA-5ygrA:
undetectable
1uduA-5ygrA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0F23980P

(Kluyveromyces
lactis)
no annotation 5 ALA A 107
PHE A 130
LEU A 119
ILE A 109
PHE A 206
None
1.07A 1uduA-6am0A:
undetectable
1uduA-6am0A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR)
no annotation 5 TYR A  94
SER A 115
VAL A 153
ALA A 152
LEU A 114
None
1.25A 1uduA-6byxA:
undetectable
1uduA-6byxA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE


(Yersinia pestis)
no annotation 5 SER C 126
VAL C  94
ALA C  93
LEU C 119
ILE C  91
None
NAP  C 501 (-3.7A)
NAP  C 501 (-4.8A)
None
None
1.27A 1uduA-6c4mC:
undetectable
1uduA-6c4mC:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens)
no annotation 5 ILE A 126
VAL A 101
ALA A  18
ILE A  16
GLN A  11
None
1.28A 1uduA-6dd6A:
undetectable
1uduA-6dd6A:
undetectable