SIMILAR PATTERNS OF AMINO ACIDS FOR 1U70_A_MTXA187

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE


(Gallus gallus)
PF00186
(DHFR_1)
8 ILE A   7
ALA A   9
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
None
None
0.61A 1u70A-1dr6A:
31.1
1u70A-1dr6A:
75.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT


(Mus musculus)
PF02883
(Alpha_adaptinC2)
5 ILE A 735
ALA A 709
PHE A 816
PRO A 755
LEU A 760
None
1.29A 1u70A-1gyuA:
undetectable
1u70A-1gyuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyv ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT


(Mus musculus)
PF02883
(Alpha_adaptinC2)
5 ILE A 735
ALA A 709
PHE A 816
PRO A 755
LEU A 760
None
1.36A 1u70A-1gyvA:
undetectable
1u70A-1gyvA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens)
PF07745
(Glyco_hydro_53)
5 ILE A 125
ALA A  69
ASN A  58
LEU A  59
ARG A 119
None
1.19A 1u70A-1hjqA:
undetectable
1u70A-1hjqA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u71 DIHYDROFOLATE
REDUCTASE


(Homo sapiens)
PF00186
(DHFR_1)
8 ILE A   7
ALA A   9
ARG A  22
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-4.5A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
1.18A 1u70A-1u71A:
31.1
1u70A-1u71A:
89.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u71 DIHYDROFOLATE
REDUCTASE


(Homo sapiens)
PF00186
(DHFR_1)
8 ILE A   7
ALA A   9
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
None
0.51A 1u70A-1u71A:
31.1
1u70A-1u71A:
89.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Escherichia
coli)
PF02348
(CTP_transf_3)
5 ILE A 104
ALA A  37
GLN A 227
ASN A 115
LEU A 126
None
1.27A 1u70A-1vh1A:
undetectable
1u70A-1vh1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1


(Arabidopsis
thaliana)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 ALA A 318
PHE A 309
GLN A 107
PRO A 268
TYR A 262
None
1.45A 1u70A-1xj5A:
undetectable
1u70A-1xj5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
vivax)
PF00186
(DHFR_1)
6 ILE A  13
ALA A  15
PRO A 122
LEU A 128
ARG A 131
TYR A 179
CP7  A1240 (-4.1A)
CP7  A1240 (-3.7A)
None
MES  A1241 (-4.5A)
MES  A1241 (-2.7A)
None
0.55A 1u70A-2blbA:
22.1
1u70A-2blbA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida)
PF11647
(MLD)
5 ILE A 941
PHE A 914
GLN A 915
PRO A1066
LEU A1046
None
1.37A 1u70A-2ec5A:
2.5
1u70A-2ec5A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ALA A  28
PRO A  85
LEU A  91
ARG A  94
TYR A 160
NAP  A 523 (-3.7A)
None
None
None
None
0.39A 1u70A-2h2qA:
22.0
1u70A-2h2qA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qk8 DIHYDROFOLATE
REDUCTASE


(Bacillus
anthracis)
PF00186
(DHFR_1)
5 ALA A   8
GLU A  28
LEU A  55
ARG A  58
TYR A 102
MTX  A 200 ( 3.4A)
MTX  A 200 ( 2.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 2.8A)
None
0.49A 1u70A-2qk8A:
20.9
1u70A-2qk8A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron)
PF00703
(Glyco_hydro_2)
5 ALA A 439
ARG A 190
GLN A 418
PRO A 193
TYR A 137
None
1.35A 1u70A-2vmfA:
undetectable
1u70A-2vmfA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus)
PF00795
(CN_hydrolase)
5 ILE A  47
ALA A 244
GLN A  50
PRO A  86
ARG A  61
None
1.49A 1u70A-2w1vA:
undetectable
1u70A-2w1vA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE


(Mycobacterium
avium)
PF00186
(DHFR_1)
5 ALA A  11
PRO A  55
LEU A  61
ARG A  64
TYR A 108
VG9  A1168 ( 3.8A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
0.74A 1u70A-2w3wA:
21.2
1u70A-2w3wA:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003


(Staphylococcus
aureus)
PF00186
(DHFR_1)
5 ILE A   5
ALA A   7
LEU A  54
ARG A  57
TYR A  98
TOP  A1160 (-4.2A)
TOP  A1160 ( 3.6A)
None
None
None
0.43A 1u70A-2w9sA:
20.3
1u70A-2w9sA:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE


(Arthrobacter
sp. KI72)
PF01425
(Amidase)
5 ILE A 177
ALA A 172
GLN A 420
PRO A 267
ASN A 266
None
ACA  A 602 (-3.6A)
None
None
None
1.33A 1u70A-3a2qA:
undetectable
1u70A-3a2qA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxm URACIL-DNA
GLYCOSYLASE


(Leishmania
naiffi)
PF03167
(UDG)
5 ILE A 292
ALA A 290
PHE A 148
PRO A 300
LEU A 303
None
1.49A 1u70A-3cxmA:
undetectable
1u70A-3cxmA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
6 ILE A  14
ALA A  16
PRO A 113
LEU A 119
ARG A 122
TYR A 170
RJ6  A 609 (-4.5A)
RJ6  A 609 (-3.7A)
None
RJ6  A 609 (-4.4A)
None
NDP  A 610 ( 4.9A)
0.43A 1u70A-3dg8A:
22.3
1u70A-3dg8A:
27.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ia4 DIHYDROFOLATE
REDUCTASE


(Moritella
profunda)
PF00186
(DHFR_1)
6 ILE A   6
ALA A   8
GLU A  28
LEU A  55
ARG A  58
TYR A 102
MTX  A 164 (-4.0A)
MTX  A 164 ( 3.7A)
MTX  A 164 (-2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 (-2.9A)
None
0.40A 1u70A-3ia4A:
20.7
1u70A-3ia4A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix9 DIHYDROFOLATE
REDUCTASE


(Streptococcus
pneumoniae)
PF00186
(DHFR_1)
5 ILE A   8
ALA A  10
GLU A  30
LEU A  58
ARG A  61
MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
0.50A 1u70A-3ix9A:
21.2
1u70A-3ix9A:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik)
no annotation 5 ILE A 127
ALA A 124
ARG A 240
PRO A 348
ARG A 132
None
1.29A 1u70A-3j26A:
undetectable
1u70A-3j26A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli)
PF01926
(MMR_HSR1)
PF14714
(KH_dom-like)
5 ILE X 292
ALA X 294
GLU X 332
PHE X 352
ASN X 363
None
None
None
None
G  B1845 ( 3.2A)
1.49A 1u70A-3j8gX:
undetectable
1u70A-3j8gX:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2


(Bluetongue
virus)
PF00898
(Orbi_VP2)
5 ILE A 422
GLN A 541
ASN A 412
LEU A 413
ARG A 549
None
1.45A 1u70A-3j9dA:
undetectable
1u70A-3j9dA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6h NITROREDUCTASE
FAMILY PROTEIN


(Agrobacterium
fabrum)
PF00881
(Nitroreductase)
5 ILE A 129
ALA A 131
PRO A  27
LEU A  24
TYR A  12
None
1.24A 1u70A-3k6hA:
undetectable
1u70A-3k6hA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE


(Babesia bovis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ALA A  16
PRO A  74
LEU A  80
ARG A  83
TYR A 129
NAP  A 512 (-3.7A)
None
None
None
None
0.78A 1u70A-3kjrA:
22.8
1u70A-3kjrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3put HYPOTHETICAL
CONSERVED PROTEIN


(Rhizobium etli)
PF08327
(AHSA1)
5 ALA A  75
GLU A  59
PHE A  38
ASN A 145
LEU A 143
None
HEZ  A 167 ( 4.3A)
HEZ  A 167 ( 4.2A)
None
HEZ  A 167 (-4.5A)
1.35A 1u70A-3putA:
undetectable
1u70A-3putA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
brucei)
PF00186
(DHFR_1)
5 ALA A  34
PRO A  91
LEU A  97
ARG A 100
TYR A 166
WRA  A 602 (-3.9A)
WRA  A 602 (-4.3A)
None
None
None
0.54A 1u70A-3rg9A:
21.9
1u70A-3rg9A:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ILE A 151
ALA A 227
PRO A 215
ASN A 216
LEU A 162
None
1.22A 1u70A-3tqpA:
undetectable
1u70A-3tqpA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ILE A  14
PRO A 113
LEU A 119
ARG A 122
TYR A 170
1CY  A 609 (-4.3A)
None
None
None
None
0.49A 1u70A-3um6A:
22.3
1u70A-3um6A:
15.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vco DIHYDROFOLATE
REDUCTASE


(Schistosoma
mansoni)
PF00186
(DHFR_1)
5 ALA A   8
PRO A  58
LEU A  64
ARG A  67
TYR A 117
None
0.63A 1u70A-3vcoA:
24.4
1u70A-3vcoA:
40.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE


(Pyrobaculum
islandicum)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 ILE A 385
ALA A 387
ARG A 334
GLN A 302
ARG A 345
None
1.47A 1u70A-3vtfA:
2.1
1u70A-3vtfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE


(Bifidobacterium
longum)
PF07944
(Glyco_hydro_127)
5 ARG A 647
GLN A 656
ASN A 572
LEU A 576
TYR A 385
None
1.42A 1u70A-3wrfA:
undetectable
1u70A-3wrfA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE


(Avian
avulavirus 1)
PF00423
(HN)
5 ILE A 565
ALA A 504
PHE A 156
GLN A 157
PRO A 560
None
1.44A 1u70A-4fzhA:
undetectable
1u70A-4fzhA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g8z DIHYDROFOLATE
REDUCTASE


(Pneumocystis
jirovecii)
PF00186
(DHFR_1)
8 ILE X  10
ALA X  12
GLU X  32
PRO X  66
ASN X  69
LEU X  72
ARG X  75
TYR X 129
TOP  X 301 (-4.2A)
NDP  X 302 ( 3.8A)
TOP  X 301 (-3.0A)
TOP  X 301 (-4.8A)
None
None
None
None
0.45A 1u70A-4g8zX:
24.9
1u70A-4g8zX:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h96 DIHYDROFOLATE
REDUCTASE


(Candida
albicans)
PF00186
(DHFR_1)
7 ILE A   9
ALA A  11
GLU A  32
PRO A  63
LEU A  69
ARG A  72
TYR A 118
14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
None
0.71A 1u70A-4h96A:
21.2
1u70A-4h96A:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h98 DIHYDROFOLATE
REDUCTASE


([Candida]
glabrata)
PF00186
(DHFR_1)
7 ILE A   9
ALA A  11
GLU A  32
PRO A  63
LEU A  69
ARG A  72
TYR A 127
14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.4A)
None
None
None
0.44A 1u70A-4h98A:
22.0
1u70A-4h98A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpd PROTEIN CYAY

(Burkholderia
cenocepacia)
PF01491
(Frataxin_Cyay)
5 ILE A  51
ALA A  65
PHE A  44
ASN A  25
LEU A  33
None
None
ACT  A 201 (-4.7A)
None
None
1.29A 1u70A-4jpdA:
undetectable
1u70A-4jpdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1


(Mycobacterium
tuberculosis)
PF05108
(T7SS_ESX1_EccB)
5 ILE A 441
ALA A 235
GLN A 349
PRO A 180
LEU A 172
None
1.23A 1u70A-4kk7A:
undetectable
1u70A-4kk7A:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m2x DIHYDROFOLATE
REDUCTASE


(Mycobacterium
tuberculosis)
PF00186
(DHFR_1)
6 ILE A   5
ALA A   7
PRO A  51
LEU A  57
ARG A  60
TYR A 100
TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.2A)
None
None
None
0.60A 1u70A-4m2xA:
20.2
1u70A-4m2xA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p68 DIHYDROFOLATE
REDUCTASE


(Escherichia
coli)
PF00186
(DHFR_1)
5 ILE A   5
ALA A   7
LYS A  55
ARG A  57
TYR A 100
MTX  A 201 (-4.1A)
MTX  A 201 ( 4.0A)
XCN  A  54 ( 3.1A)
MTX  A 201 (-3.0A)
None
1.11A 1u70A-4p68A:
20.4
1u70A-4p68A:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE


(Brucella
abortus)
PF01041
(DegT_DnrJ_EryC1)
5 ILE A 309
GLN A 359
PRO A 277
ASN A 267
LEU A 270
None
1.17A 1u70A-4qgrA:
undetectable
1u70A-4qgrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE


(Mycobacterium
avium)
PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ALA A1012
ARG A1014
PHE A1034
LEU A 854
TYR A 978
None
1.47A 1u70A-4rcnA:
undetectable
1u70A-4rcnA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 ILE A 191
ALA A 140
PHE A 129
GLN A 131
TYR A 204
None
1.45A 1u70A-4um8A:
undetectable
1u70A-4um8A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Pseudomonas
aeruginosa)
PF01425
(Amidase)
5 ILE A 397
GLN A 459
PRO A 191
LEU A 463
TYR A 265
None
1.50A 1u70A-4wj3A:
undetectable
1u70A-4wj3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byu THIOESTERASE

(Legionella
pneumophila)
PF13279
(4HBT_2)
5 ILE A  77
ALA A 103
PHE A  32
GLN A  36
ARG A  39
None
1.41A 1u70A-5byuA:
undetectable
1u70A-5byuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxv RETHREADED DHFR

(synthetic
construct)
PF00186
(DHFR_1)
5 ILE A   5
ALA A   7
LEU A  71
ARG A  74
TYR A 117
None
NAP  A 201 (-3.7A)
None
None
None
0.30A 1u70A-5dxvA:
12.5
1u70A-5dxvA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus)
PF02016
(Peptidase_S66)
5 ILE A 100
ALA A 104
GLN A  66
PRO A  52
ASN A  53
None
1.23A 1u70A-5f1yA:
undetectable
1u70A-5f1yA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fda DIHYDROFOLATE
REDUCTASE


(Yersinia pestis)
PF00186
(DHFR_1)
5 ILE A   6
ALA A   8
LEU A  55
ARG A  58
TYR A 101
None
1.23A 1u70A-5fdaA:
14.6
1u70A-5fdaA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S


(Oryctolagus
cuniculus)
PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH)
5 ILE A 822
PHE A1306
GLN A1311
ASN A1304
LEU A1294
None
None
PC1  A1915 (-3.7A)
None
None
1.45A 1u70A-5gjvA:
undetectable
1u70A-5gjvA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnw BLR0248 PROTEIN

(Bradyrhizobium
diazoefficiens)
no annotation 5 ALA C 134
PHE C  80
GLN C  78
LEU C  69
ARG C  42
None
None
None
URA  C 301 (-3.9A)
None
1.35A 1u70A-5gnwC:
undetectable
1u70A-5gnwC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mll DNA PROCESSING CHAIN
A (DPRA)


(Helicobacter
pylori)
no annotation 5 ILE A  76
ALA A  47
ARG A 143
PRO A 109
ASN A 112
None
1.39A 1u70A-5mllA:
undetectable
1u70A-5mllA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE


(Cupriavidus
metallidurans)
PF00724
(Oxidored_FMN)
5 ILE A 172
ALA A 164
ARG A 219
ASN A  12
LEU A  13
None
1.43A 1u70A-5ocsA:
undetectable
1u70A-5ocsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 5 ILE A 257
ALA A 240
ARG A 518
GLN A 530
ARG A 253
None
1.47A 1u70A-5ohsA:
undetectable
1u70A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
6 ALA A  10
PHE A  32
PRO A  88
LEU A  94
ARG A  97
TYR A 157
73X  A 704 (-4.0A)
73X  A 704 (-4.7A)
73X  A 704 (-4.0A)
None
None
None
0.51A 1u70A-5t0lA:
23.8
1u70A-5t0lA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgc NLEG5-1 EFFECTOR

(Enterobacteria
phage YYZ-2008)
no annotation 5 ILE A 189
ALA A 181
GLN A 113
ASN A 111
LEU A 114
None
CL  A 306 ( 4.6A)
None
None
None
1.47A 1u70A-5vgcA:
undetectable
1u70A-5vgcA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa0 PUTATIVE SULFITE
OXIDASE


(Sinorhizobium
meliloti)
no annotation 5 ILE A  99
ALA A 250
PRO A 206
ASN A 209
LEU A 210
None
1.39A 1u70A-5wa0A:
undetectable
1u70A-5wa0A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2


(Leptotrichia
shahii)
no annotation 5 ILE A 707
ALA A 705
PHE A 795
ASN A 687
LEU A 683
None
1.44A 1u70A-5wtkA:
undetectable
1u70A-5wtkA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S


(Oryctolagus
cuniculus)
no annotation 5 ILE A 822
PHE A1306
GLN A1311
ASN A1304
LEU A1294
None
1.45A 1u70A-6byoA:
undetectable
1u70A-6byoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE


(Mycolicibacterium
smegmatis)
no annotation 6 ILE A   6
ALA A   8
PRO A  52
LEU A  58
ARG A  61
TYR A  98
MMV  A 202 (-4.0A)
NAP  A 201 (-3.9A)
MMV  A 202 ( 4.6A)
MMV  A 202 (-4.2A)
MMV  A 202 (-2.8A)
None
0.53A 1u70A-6cxmA:
19.8
1u70A-6cxmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1


(Zaire
ebolavirus)
no annotation 5 ALA A  82
GLU A 178
PHE A 160
LEU A 122
TYR A 232
None
1.43A 1u70A-6f5uA:
undetectable
1u70A-6f5uA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1


(Zaire
ebolavirus)
no annotation 5 ALA A  82
GLU A 178
PHE A 160
LEU A 122
TYR A 232
GOL  A 506 ( 4.7A)
GOL  A 506 (-4.0A)
None
None
None
1.38A 1u70A-6f6sA:
undetectable
1u70A-6f6sA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare)
PF00332
(Glyco_hydro_17)
4 SER A 181
ILE A 180
VAL A 193
THR A 262
None
1.19A 1u70A-1ghsA:
0.2
1u70A-1ghsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE


(Homo sapiens)
PF13460
(NAD_binding_10)
4 SER A 202
ILE A 176
VAL A 149
THR A 191
None
1.12A 1u70A-1he3A:
1.8
1u70A-1he3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC


(Thermotoga
maritima)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 SER A 435
ILE A 431
VAL A 343
THR A 331
None
1.07A 1u70A-1j6uA:
4.2
1u70A-1j6uA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1


(Hordeum vulgare)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
4 SER A 524
ILE A 523
VAL A 541
THR A 564
None
1.23A 1u70A-1lq2A:
undetectable
1u70A-1lq2A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE


(Escherichia
coli)
PF16363
(GDP_Man_Dehyd)
4 SER A 171
ILE A 172
VAL A  77
THR A  16
None
0.96A 1u70A-1lrkA:
0.8
1u70A-1lrkA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
4 SER A 139
ILE A 138
VAL A 234
THR A 201
None
NAD  A1300 (-4.4A)
None
None
1.23A 1u70A-1nffA:
1.9
1u70A-1nffA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 SER A 295
ILE A 296
VAL A 249
THR A 167
None
1.09A 1u70A-1q1nA:
1.8
1u70A-1q1nA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Plasmodium
falciparum)
PF00160
(Pro_isomerase)
4 SER A  27
ILE A  29
VAL A 134
THR A 122
None
1.18A 1u70A-1qnhA:
undetectable
1u70A-1qnhA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqe HYPOTHETICAL PROTEIN
PG130


(Staphylococcus
aureus)
PF03992
(ABM)
4 SER A 110
ILE A 108
VAL A  67
THR A  71
None
0.79A 1u70A-1sqeA:
undetectable
1u70A-1sqeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger)
PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N)
4 SER A 113
ILE A 112
VAL A  74
THR A  40
None
1.23A 1u70A-1wmrA:
undetectable
1u70A-1wmrA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 B-PHYCOERYTHRIN BETA
CHAIN


(Rhodomonas sp.
CS24)
PF00502
(Phycobilisome)
4 SER C  32
ILE C  31
VAL C  41
THR C 153
None
None
None
PEB  C 258 (-4.3A)
1.21A 1u70A-1xg0C:
undetectable
1u70A-1xg0C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM


(Thermoplasma
acidophilum)
PF01729
(QRPTase_C)
4 SER A 296
ILE A 295
VAL A 163
THR A 179
None
None
None
NCN  A 401 (-3.1A)
1.05A 1u70A-1ytkA:
undetectable
1u70A-1ytkA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkp HYPOTHETICAL PROTEIN
BA1088


(Bacillus
anthracis)
PF12706
(Lactamase_B_2)
4 SER A 128
ILE A 127
VAL A 150
THR A 210
None
1.21A 1u70A-1zkpA:
undetectable
1u70A-1zkpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli)
PF01144
(CoA_trans)
4 SER A  80
ILE A  79
VAL A  88
THR A 158
None
1.22A 1u70A-2ahwA:
undetectable
1u70A-2ahwA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata)
PF00332
(Glyco_hydro_17)
4 SER A 215
ILE A 214
VAL A 228
THR A 296
None
0.98A 1u70A-2cygA:
undetectable
1u70A-2cygA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D


(Methanothermobacter
thermautotrophicus)
PF00710
(Asparaginase)
4 SER A  94
ILE A  95
VAL A 198
THR A 183
None
1.15A 1u70A-2d6fA:
undetectable
1u70A-2d6fA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC


(Thermotoga
maritima)
PF04509
(CheC)
4 SER A  37
ILE A  36
VAL A 174
THR A  82
None
1.25A 1u70A-2f9zA:
undetectable
1u70A-2f9zA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis)
PF01979
(Amidohydro_1)
4 SER A 353
ILE A 357
VAL A 302
THR A 255
None
1.18A 1u70A-2gwnA:
undetectable
1u70A-2gwnA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis)
PF03309
(Pan_kinase)
4 SER X 228
ILE X 227
VAL X 128
THR X 242
None
1.11A 1u70A-2h3gX:
undetectable
1u70A-2h3gX:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE


(Streptomyces
exfoliatus)
PF13561
(adh_short_C2)
4 SER A 138
ILE A 137
VAL A 239
THR A 205
None
NAD  A 256 (-4.6A)
None
None
1.14A 1u70A-2hsdA:
2.1
1u70A-2hsdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqa MINOR AMPULLATE
FIBROIN 1


(Nephila
antipodiana)
PF12042
(RP1-2)
4 SER A 112
ILE A 111
VAL A  58
THR A 128
None
1.05A 1u70A-2mqaA:
undetectable
1u70A-2mqaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME


(Burkholderia
pseudomallei)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 SER A 221
ILE A 247
VAL A 266
THR A 240
None
0.96A 1u70A-2podA:
undetectable
1u70A-2podA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN


(Staphylococcus
epidermidis)
PF01933
(UPF0052)
4 SER A 281
ILE A 283
VAL A 273
THR A 224
None
1.20A 1u70A-2ppvA:
1.8
1u70A-2ppvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE


(Medicago
truncatula)
PF00201
(UDPGT)
4 SER A 251
ILE A 252
VAL A 223
THR A 131
None
0.75A 1u70A-2pq6A:
undetectable
1u70A-2pq6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG


(Aeropyrum
pernix)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
4 SER A 310
ILE A 311
VAL A 385
THR A 299
None
1.24A 1u70A-2v1uA:
undetectable
1u70A-2v1uA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX


(Bacillus
subtilis)
PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N)
4 SER A 114
ILE A 113
VAL A 148
THR A 162
None
1.24A 1u70A-2vt2A:
2.2
1u70A-2vt2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
PF01163
(RIO1)
4 SER A 379
ILE A 376
VAL A 192
THR A 453
None
1.06A 1u70A-2vwbA:
undetectable
1u70A-2vwbA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
4 SER A1056
ILE A1057
VAL A1089
THR A 972
None
1.21A 1u70A-2vz9A:
undetectable
1u70A-2vz9A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130


(Drosophila
melanogaster)
PF00225
(Kinesin)
4 SER C 145
ILE C 144
VAL C 227
THR C 313
None
1.15A 1u70A-2wbeC:
undetectable
1u70A-2wbeC:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 SER A 175
ILE A 178
VAL A 359
THR A  32
None
1.00A 1u70A-2wgeA:
undetectable
1u70A-2wgeA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus)
no annotation 4 SER A 404
ILE A 406
VAL A 199
THR A 217
None
1.03A 1u70A-2x0fA:
undetectable
1u70A-2x0fA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Thermotoga
maritima)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
4 SER B 166
ILE B 164
VAL B 227
THR B 262
None
1.23A 1u70A-3al0B:
undetectable
1u70A-3al0B:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes)
PF12799
(LRR_4)
4 SER A 103
ILE A 105
VAL A  75
THR A  84
None
1.06A 1u70A-3bz5A:
undetectable
1u70A-3bz5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch2 SERINE-REPEAT
ANTIGEN PROTEIN


(Plasmodium
falciparum)
PF00112
(Peptidase_C1)
4 SER X 816
ILE X 814
VAL X 764
THR X 607
None
1.13A 1u70A-3ch2X:
undetectable
1u70A-3ch2X:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE


(Homo sapiens)
PF02390
(Methyltransf_4)
4 SER A 109
ILE A  78
VAL A  82
THR A 208
None
SAM  A 301 (-3.8A)
None
SAM  A 301 (-2.8A)
0.96A 1u70A-3ckkA:
undetectable
1u70A-3ckkA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE


(Methanocaldococcus
jannaschii)
PF00398
(RrnaAD)
4 SER A 107
ILE A 110
VAL A  98
THR A  45
None
1.01A 1u70A-3fydA:
undetectable
1u70A-3fydA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2p PCZA361.24

(Amycolatopsis
orientalis)
PF13649
(Methyltransf_25)
4 SER A 139
ILE A 142
VAL A 268
THR A  60
None
1.00A 1u70A-3g2pA:
undetectable
1u70A-3g2pA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE


(Brucella
abortus)
PF13561
(adh_short_C2)
4 SER A 145
ILE A 144
VAL A 246
THR A 213
None
1.23A 1u70A-3gafA:
undetectable
1u70A-3gafA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grk ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)


(Brucella
melitensis)
PF13561
(adh_short_C2)
4 SER A 191
ILE A 190
VAL A 223
THR A 197
None
1.21A 1u70A-3grkA:
undetectable
1u70A-3grkA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE


(Methanocaldococcus
jannaschii)
PF00398
(RrnaAD)
4 SER A 107
ILE A 110
VAL A  98
THR A  45
None
0.89A 1u70A-3gryA:
undetectable
1u70A-3gryA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A


(Drosophila
melanogaster)
PF00225
(Kinesin)
4 SER K 503
ILE K 506
VAL K 416
THR K 404
None
1.25A 1u70A-3j2uK:
undetectable
1u70A-3j2uK:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11


(Schizosaccharomyces
pombe)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
4 SER X1151
ILE X1150
VAL X1143
THR X1100
None
1.01A 1u70A-3jb9X:
undetectable
1u70A-3jb9X:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkl PROBABLE CHAPERONE
PROTEIN HSP33


(Saccharomyces
cerevisiae)
no annotation 4 SER A   9
ILE A   8
VAL A 101
THR A 211
None
1.18A 1u70A-3kklA:
undetectable
1u70A-3kklA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
4 SER A 569
ILE A 568
VAL A 435
THR A 198
None
LYS  A 603 (-4.5A)
None
None
1.21A 1u70A-3l76A:
undetectable
1u70A-3l76A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE


(Corynebacterium
glutamicum)
PF13409
(GST_N_2)
PF13410
(GST_C_2)
4 SER A  87
ILE A  86
VAL A 147
THR A 134
None
1.24A 1u70A-3m1gA:
undetectable
1u70A-3m1gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1


(Sus scrofa)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
4 SER A 200
ILE A 199
VAL A 184
THR A 240
None
1.10A 1u70A-3n23A:
undetectable
1u70A-3n23A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus)
PF08762
(CRPV_capsid)
4 SER A 238
ILE A 237
VAL A 253
THR A 257
None
1.25A 1u70A-3napA:
undetectable
1u70A-3napA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P


(Drosophila
melanogaster)
PF11701
(UNC45-central)
4 SER A 648
ILE A 652
VAL A 578
THR A 544
None
1.25A 1u70A-3nowA:
undetectable
1u70A-3nowA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT


(Komagataella
pastoris)
PF00365
(PFK)
4 SER B 443
ILE B 442
VAL B 450
THR B 426
None
1.18A 1u70A-3opyB:
undetectable
1u70A-3opyB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Bartonella
henselae)
PF00698
(Acyl_transf_1)
4 SER A  69
ILE A  73
VAL A  90
THR A 273
None
1.00A 1u70A-3qatA:
undetectable
1u70A-3qatA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwn HYPOTHETICAL
NIGD-LIKE PROTEIN


(Bacteroides
caccae)
PF12667
(NigD_N)
PF17415
(NigD_C)
4 SER A  95
ILE A  93
VAL A  36
THR A 101
None
None
None
CL  A 262 ( 4.3A)
1.10A 1u70A-3qwnA:
undetectable
1u70A-3qwnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
ulcerans)
PF13561
(adh_short_C2)
4 SER A 146
ILE A 145
VAL A 248
THR A 215
None
1.18A 1u70A-3svtA:
undetectable
1u70A-3svtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
4 SER A 155
ILE A 154
VAL A 206
THR A 216
None
NAD  A 300 (-4.7A)
NAD  A 300 (-4.1A)
None
1.17A 1u70A-3sx2A:
undetectable
1u70A-3sx2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE


(Campylobacter
jejuni)
PF04166
(PdxA)
4 SER A   7
ILE A   6
VAL A 330
THR A 334
None
1.05A 1u70A-3tsnA:
undetectable
1u70A-3tsnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 SER A  22
ILE A  23
VAL A 114
THR A 130
None
1.09A 1u70A-3vf1A:
undetectable
1u70A-3vf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E


(Streptomyces
cinnabarigriseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 SER A 235
ILE A 238
VAL A 252
THR A 318
None
None
NAP  A1447 (-3.8A)
None
1.20A 1u70A-4a0sA:
2.2
1u70A-4a0sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE


(Sphingomonas
elodea)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 SER A 338
ILE A 340
VAL A 387
THR A 430
None
1.18A 1u70A-4a7pA:
undetectable
1u70A-4a7pA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1


(Pseudomonas
virus phi6)
no annotation 4 SER A 539
ILE A 535
VAL A  31
THR A  17
None
1.02A 1u70A-4btgA:
undetectable
1u70A-4btgA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 SER A 248
ILE A 247
VAL A 239
THR A 276
1PE  A 306 (-3.1A)
1PE  A 306 ( 3.9A)
1PE  A 306 (-4.6A)
None
1.19A 1u70A-4e13A:
undetectable
1u70A-4e13A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN


(Staphylococcus
aureus)
no annotation 4 SER B2171
ILE B2226
VAL B2193
THR B2187
None
1.13A 1u70A-4f6lB:
undetectable
1u70A-4f6lB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
4 SER A 304
ILE A 306
VAL A 519
THR A 537
None
0.97A 1u70A-4gvlA:
2.5
1u70A-4gvlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'


(Hevea
brasiliensis)
PF00332
(Glyco_hydro_17)
4 SER A 191
ILE A 190
VAL A 204
THR A 271
None
1.04A 1u70A-4iisA:
undetectable
1u70A-4iisA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE


(Caenorhabditis
elegans)
PF00481
(PP2C)
4 SER A 401
ILE A 404
VAL A 417
THR A 263
None
1.24A 1u70A-4jndA:
undetectable
1u70A-4jndA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
4 SER A 140
ILE A 139
VAL A 243
THR A 210
None
1.16A 1u70A-4mowA:
undetectable
1u70A-4mowA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Acholeplasma
laidlawii)
PF13561
(adh_short_C2)
4 SER A 132
ILE A 131
VAL A 234
THR A 201
None
NAD  A 301 (-3.9A)
None
None
1.15A 1u70A-4nbtA:
undetectable
1u70A-4nbtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odi PHOSPHOGLYCERATE
MUTASE PGMII


(Toxoplasma
gondii)
PF00300
(His_Phos_1)
4 SER A 187
ILE A 188
VAL A 196
THR A  89
None
1.14A 1u70A-4odiA:
1.7
1u70A-4odiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN


(Streptomyces
pristinaespiralis)
no annotation 4 SER A 322
ILE A 306
VAL A   7
THR A 329
None
1.24A 1u70A-4okmA:
undetectable
1u70A-4okmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q34 UNCHARACTERIZED
PROTEIN


(Parabacteroides
distasonis)
PF12697
(Abhydrolase_6)
4 SER A 215
ILE A 262
VAL A 222
THR A 237
None
1.13A 1u70A-4q34A:
undetectable
1u70A-4q34A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00571
(CBS)
4 SER G  54
ILE G 114
VAL G  83
THR G 163
None
1.19A 1u70A-4rerG:
undetectable
1u70A-4rerG:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umg PROTEIN LIN-41

(Caenorhabditis
elegans)
PF00630
(Filamin)
4 SER A 699
ILE A 808
VAL A 785
THR A 714
None
1.06A 1u70A-4umgA:
undetectable
1u70A-4umgA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE


(Haemophilus
influenzae)
PF00106
(adh_short)
4 SER A 167
ILE A 166
VAL A 275
THR A 241
None
NAD  A 301 (-3.9A)
None
None
1.16A 1u70A-4wuvA:
undetectable
1u70A-4wuvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 SER A 216
ILE A 219
VAL A 233
THR A 306
None
None
NAP  A 501 (-3.9A)
NAP  A 501 (-3.9A)
1.04A 1u70A-4y1bA:
2.2
1u70A-4y1bA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
4 SER A 282
ILE A 281
VAL A 389
THR A 513
None
1.08A 1u70A-4ydqA:
undetectable
1u70A-4ydqA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens)
PF00294
(PfkB)
4 SER A  94
ILE A  93
VAL A  20
THR A 159
None
1.23A 1u70A-5c41A:
undetectable
1u70A-5c41A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Cryptococcus
neoformans)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 SER A 208
ILE A 207
VAL A 194
THR A  17
None
0.91A 1u70A-5cefA:
undetectable
1u70A-5cefA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))


(Clostridioides
difficile)
PF08501
(Shikimate_dh_N)
4 SER A 243
ILE A 246
VAL A  85
THR A 135
None
1.10A 1u70A-5dzsA:
2.0
1u70A-5dzsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum)
PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C)
4 SER A2099
ILE A2100
VAL A2144
THR A2273
None
1.25A 1u70A-5ejsA:
undetectable
1u70A-5ejsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
4 SER C 262
ILE C 260
VAL C 318
THR C 382
None
1.23A 1u70A-5flzC:
undetectable
1u70A-5flzC:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR


(Acinetobacter
baumannii)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 SER A 131
ILE A 129
VAL A  96
THR A  92
None
1.01A 1u70A-5fr8A:
undetectable
1u70A-5fr8A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1


(Thielavia
terrestris)
PF05183
(RdRP)
4 SER A 590
ILE A 592
VAL A 721
THR A 708
None
1.23A 1u70A-5fswA:
undetectable
1u70A-5fswA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES


(Corynebacterium
glutamicum)
PF00933
(Glyco_hydro_3)
4 SER A 358
ILE A 360
VAL A  79
THR A 318
None
1.13A 1u70A-5iobA:
undetectable
1u70A-5iobA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD


(Klebsiella
pneumoniae)
PF03968
(OstA)
PF04390
(LptE)
PF04453
(OstA_C)
4 SER B  81
ILE B  82
VAL B 122
THR A 614
None
1.04A 1u70A-5iv9B:
undetectable
1u70A-5iv9B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum)
PF00026
(Asp)
4 SER A 278
ILE A 280
VAL A 246
THR A 219
None
1.24A 1u70A-5jodA:
undetectable
1u70A-5jodA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1


(Acidaminococcus
sp. BV3L6)
no annotation 4 SER A 778
ILE A 779
VAL A1027
THR A1046
None
1.02A 1u70A-5kk5A:
undetectable
1u70A-5kk5A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus)
no annotation 4 SER A 236
ILE A 235
VAL A 265
THR A  56
None
1.25A 1u70A-5mktA:
undetectable
1u70A-5mktA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1
VP3


(Black queen
cell virus)
PF08762
(CRPV_capsid)
no annotation
4 SER C 119
ILE C 117
VAL A 109
THR C  22
None
1.25A 1u70A-5mqcC:
undetectable
1u70A-5mqcC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tge PHAGE TERMINASE
LARGE SUBUNIT


(Thermus virus
P74-26)
PF17289
(Terminase_6C)
4 SER A 382
ILE A 381
VAL A 371
THR A 367
None
1.07A 1u70A-5tgeA:
undetectable
1u70A-5tgeA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 SER A 604
ILE A 603
VAL A 477
THR A 556
None
1.16A 1u70A-5ujaA:
undetectable
1u70A-5ujaA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1


(Schizosaccharomyces
pombe)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
4 SER A 161
ILE A 162
VAL A 127
THR A 143
None
1.10A 1u70A-5um6A:
undetectable
1u70A-5um6A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE


(Homo sapiens)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
4 SER A1044
ILE A1043
VAL A1151
THR A1277
None
1.16A 1u70A-5vadA:
undetectable
1u70A-5vadA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x33 LTB4
RECEPTOR,LYSOZYME,LT
B4 RECEPTOR


(Cavia
porcellus;
Escherichia
virus T4)
no annotation 4 SER A 202
ILE A 206
VAL A 226
THR A  55
None
1.20A 1u70A-5x33A:
undetectable
1u70A-5x33A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1


(Homo sapiens)
PF00514
(Arm)
4 SER A 422
ILE A 425
VAL A 398
THR A 355
None
1.24A 1u70A-5xgcA:
undetectable
1u70A-5xgcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)


(Cryptosporidium
parvum)
no annotation 4 SER A 254
ILE A 253
VAL A 361
THR A 485
None
1.09A 1u70A-5xioA:
undetectable
1u70A-5xioA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE


(Eimeria tenella)
no annotation 4 SER A 282
ILE A 281
VAL A 389
THR A 513
None
1.17A 1u70A-5xipA:
undetectable
1u70A-5xipA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)


(Rhizomucor
miehei)
no annotation 4 SER A 385
ILE A 384
VAL A 281
THR A 316
None
1.11A 1u70A-5xwqA:
undetectable
1u70A-5xwqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E


(Pseudomonas sp.
AIU 813)
no annotation 4 SER A 106
ILE A  15
VAL A 250
THR A 232
None
1.19A 1u70A-5yb7A:
undetectable
1u70A-5yb7A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8


(Homo sapiens)
no annotation 4 SER E1422
ILE E1423
VAL E1533
THR E1541
None
1.21A 1u70A-6c3pE:
undetectable
1u70A-6c3pE:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-)
no annotation 4 SER D  38
ILE D  37
VAL D  30
THR D  73
None
1.18A 1u70A-6f45D:
undetectable
1u70A-6f45D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE


(Acetobacterium
woodii)
no annotation 4 SER A 145
ILE A 148
VAL A 179
THR B  95
None
None
None
FAD  B 301 (-2.7A)
0.99A 1u70A-6fahA:
2.2
1u70A-6fahA:
19.88