SIMILAR PATTERNS OF AMINO ACIDS FOR 1U70_A_MTXA187
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 8 | ILE A 7ALA A 9GLU A 30PRO A 61ASN A 64LEU A 67ARG A 70TYR A 121 | HBI A 198 (-4.1A)HBI A 198 ( 3.6A)HBI A 198 (-3.0A)NoneNoneNoneNoneNone | 0.61A | 1u70A-1dr6A:31.1 | 1u70A-1dr6A:75.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyu | ADAPTER-RELATEDPROTEIN COMPLEX 1GAMMA 1 SUBUNIT (Mus musculus) |
PF02883(Alpha_adaptinC2) | 5 | ILE A 735ALA A 709PHE A 816PRO A 755LEU A 760 | None | 1.29A | 1u70A-1gyuA:undetectable | 1u70A-1gyuA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyv | ADAPTER-RELATEDPROTEIN COMPLEX 1GAMMA 1 SUBUNIT (Mus musculus) |
PF02883(Alpha_adaptinC2) | 5 | ILE A 735ALA A 709PHE A 816PRO A 755LEU A 760 | None | 1.36A | 1u70A-1gyvA:undetectable | 1u70A-1gyvA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hjq | BETA-1,4-GALACTANASE (Humicolainsolens) |
PF07745(Glyco_hydro_53) | 5 | ILE A 125ALA A 69ASN A 58LEU A 59ARG A 119 | None | 1.19A | 1u70A-1hjqA:undetectable | 1u70A-1hjqA:18.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u71 | DIHYDROFOLATEREDUCTASE (Homo sapiens) |
PF00186(DHFR_1) | 8 | ILE A 7ALA A 9ARG A 22GLU A 30PRO A 61ASN A 64LEU A 67ARG A 70 | MXA A 187 (-4.5A)MXA A 187 (-3.6A)MXA A 187 (-4.5A)MXA A 187 (-2.9A)MXA A 187 (-4.4A)MXA A 187 (-4.5A)NoneNone | 1.18A | 1u70A-1u71A:31.1 | 1u70A-1u71A:89.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u71 | DIHYDROFOLATEREDUCTASE (Homo sapiens) |
PF00186(DHFR_1) | 8 | ILE A 7ALA A 9GLU A 30PRO A 61ASN A 64LEU A 67ARG A 70TYR A 121 | MXA A 187 (-4.5A)MXA A 187 (-3.6A)MXA A 187 (-2.9A)MXA A 187 (-4.4A)MXA A 187 (-4.5A)NoneNoneNone | 0.51A | 1u70A-1u71A:31.1 | 1u70A-1u71A:89.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vh1 | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Escherichiacoli) |
PF02348(CTP_transf_3) | 5 | ILE A 104ALA A 37GLN A 227ASN A 115LEU A 126 | None | 1.27A | 1u70A-1vh1A:undetectable | 1u70A-1vh1A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xj5 | SPERMIDINE SYNTHASE1 (Arabidopsisthaliana) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | ALA A 318PHE A 309GLN A 107PRO A 268TYR A 262 | None | 1.45A | 1u70A-1xj5A:undetectable | 1u70A-1xj5A:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 6 | ILE A 13ALA A 15PRO A 122LEU A 128ARG A 131TYR A 179 | CP7 A1240 (-4.1A)CP7 A1240 (-3.7A)NoneMES A1241 (-4.5A)MES A1241 (-2.7A)None | 0.55A | 1u70A-2blbA:22.1 | 1u70A-2blbA:29.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ec5 | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 5 | ILE A 941PHE A 914GLN A 915PRO A1066LEU A1046 | None | 1.37A | 1u70A-2ec5A:2.5 | 1u70A-2ec5A:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 28PRO A 85LEU A 91ARG A 94TYR A 160 | NAP A 523 (-3.7A)NoneNoneNoneNone | 0.39A | 1u70A-2h2qA:22.0 | 1u70A-2h2qA:18.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qk8 | DIHYDROFOLATEREDUCTASE (Bacillusanthracis) |
PF00186(DHFR_1) | 5 | ALA A 8GLU A 28LEU A 55ARG A 58TYR A 102 | MTX A 200 ( 3.4A)MTX A 200 ( 2.8A)MTX A 200 ( 4.1A)MTX A 200 ( 2.8A)None | 0.49A | 1u70A-2qk8A:20.9 | 1u70A-2qk8A:33.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmf | BETA-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2) | 5 | ALA A 439ARG A 190GLN A 418PRO A 193TYR A 137 | None | 1.35A | 1u70A-2vmfA:undetectable | 1u70A-2vmfA:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1v | NITRILASE HOMOLOG 2 (Mus musculus) |
PF00795(CN_hydrolase) | 5 | ILE A 47ALA A 244GLN A 50PRO A 86ARG A 61 | None | 1.49A | 1u70A-2w1vA:undetectable | 1u70A-2w1vA:20.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 5 | ALA A 11PRO A 55LEU A 61ARG A 64TYR A 108 | VG9 A1168 ( 3.8A)VG9 A1168 ( 4.6A)VG9 A1168 ( 4.4A)VG9 A1168 ( 3.7A)None | 0.74A | 1u70A-2w3wA:21.2 | 1u70A-2w3wA:32.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 5 | ILE A 5ALA A 7LEU A 54ARG A 57TYR A 98 | TOP A1160 (-4.2A)TOP A1160 ( 3.6A)NoneNoneNone | 0.43A | 1u70A-2w9sA:20.3 | 1u70A-2w9sA:33.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2q | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobactersp. KI72) |
PF01425(Amidase) | 5 | ILE A 177ALA A 172GLN A 420PRO A 267ASN A 266 | NoneACA A 602 (-3.6A)NoneNoneNone | 1.33A | 1u70A-3a2qA:undetectable | 1u70A-3a2qA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cxm | URACIL-DNAGLYCOSYLASE (Leishmanianaiffi) |
PF03167(UDG) | 5 | ILE A 292ALA A 290PHE A 148PRO A 300LEU A 303 | None | 1.49A | 1u70A-3cxmA:undetectable | 1u70A-3cxmA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 6 | ILE A 14ALA A 16PRO A 113LEU A 119ARG A 122TYR A 170 | RJ6 A 609 (-4.5A)RJ6 A 609 (-3.7A)NoneRJ6 A 609 (-4.4A)NoneNDP A 610 ( 4.9A) | 0.43A | 1u70A-3dg8A:22.3 | 1u70A-3dg8A:27.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 6 | ILE A 6ALA A 8GLU A 28LEU A 55ARG A 58TYR A 102 | MTX A 164 (-4.0A)MTX A 164 ( 3.7A)MTX A 164 (-2.9A)MTX A 164 ( 4.4A)MTX A 164 (-2.9A)None | 0.40A | 1u70A-3ia4A:20.7 | 1u70A-3ia4A:31.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ix9 | DIHYDROFOLATEREDUCTASE (Streptococcuspneumoniae) |
PF00186(DHFR_1) | 5 | ILE A 8ALA A 10GLU A 30LEU A 58ARG A 61 | MTX A 200 (-4.1A)MTX A 200 (-3.8A)MTX A 200 (-2.7A)MTX A 200 ( 4.0A)MTX A 200 (-2.9A) | 0.50A | 1u70A-3ix9A:21.2 | 1u70A-3ix9A:32.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j26 | CAPSID PROTEIN V20 (Mimivirus-dependentvirus Sputnik) |
no annotation | 5 | ILE A 127ALA A 124ARG A 240PRO A 348ARG A 132 | None | 1.29A | 1u70A-3j26A:undetectable | 1u70A-3j26A:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j8g | GTPASE DER (Escherichiacoli) |
PF01926(MMR_HSR1)PF14714(KH_dom-like) | 5 | ILE X 292ALA X 294GLU X 332PHE X 352ASN X 363 | NoneNoneNoneNone G B1845 ( 3.2A) | 1.49A | 1u70A-3j8gX:undetectable | 1u70A-3j8gX:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 5 | ILE A 422GLN A 541ASN A 412LEU A 413ARG A 549 | None | 1.45A | 1u70A-3j9dA:undetectable | 1u70A-3j9dA:11.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6h | NITROREDUCTASEFAMILY PROTEIN (Agrobacteriumfabrum) |
PF00881(Nitroreductase) | 5 | ILE A 129ALA A 131PRO A 27LEU A 24TYR A 12 | None | 1.24A | 1u70A-3k6hA:undetectable | 1u70A-3k6hA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 16PRO A 74LEU A 80ARG A 83TYR A 129 | NAP A 512 (-3.7A)NoneNoneNoneNone | 0.78A | 1u70A-3kjrA:22.8 | 1u70A-3kjrA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3put | HYPOTHETICALCONSERVED PROTEIN (Rhizobium etli) |
PF08327(AHSA1) | 5 | ALA A 75GLU A 59PHE A 38ASN A 145LEU A 143 | NoneHEZ A 167 ( 4.3A)HEZ A 167 ( 4.2A)NoneHEZ A 167 (-4.5A) | 1.35A | 1u70A-3putA:undetectable | 1u70A-3putA:21.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rg9 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomabrucei) |
PF00186(DHFR_1) | 5 | ALA A 34PRO A 91LEU A 97ARG A 100TYR A 166 | WRA A 602 (-3.9A)WRA A 602 (-4.3A)NoneNoneNone | 0.54A | 1u70A-3rg9A:21.9 | 1u70A-3rg9A:31.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqp | ENOLASE (Coxiellaburnetii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ILE A 151ALA A 227PRO A 215ASN A 216LEU A 162 | None | 1.22A | 1u70A-3tqpA:undetectable | 1u70A-3tqpA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ILE A 14PRO A 113LEU A 119ARG A 122TYR A 170 | 1CY A 609 (-4.3A)NoneNoneNoneNone | 0.49A | 1u70A-3um6A:22.3 | 1u70A-3um6A:15.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 5 | ALA A 8PRO A 58LEU A 64ARG A 67TYR A 117 | None | 0.63A | 1u70A-3vcoA:24.4 | 1u70A-3vcoA:40.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtf | UDP-GLUCOSE6-DEHYDROGENASE (Pyrobaculumislandicum) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | ILE A 385ALA A 387ARG A 334GLN A 302ARG A 345 | None | 1.47A | 1u70A-3vtfA:2.1 | 1u70A-3vtfA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrf | NON-REDUCING ENDBETA-L-ARABINOFURANOSIDASE (Bifidobacteriumlongum) |
PF07944(Glyco_hydro_127) | 5 | ARG A 647GLN A 656ASN A 572LEU A 576TYR A 385 | None | 1.42A | 1u70A-3wrfA:undetectable | 1u70A-3wrfA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzh | HEMAGGLUTININ-NEURAMINIDASE (Avianavulavirus 1) |
PF00423(HN) | 5 | ILE A 565ALA A 504PHE A 156GLN A 157PRO A 560 | None | 1.44A | 1u70A-4fzhA:undetectable | 1u70A-4fzhA:16.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 8 | ILE X 10ALA X 12GLU X 32PRO X 66ASN X 69LEU X 72ARG X 75TYR X 129 | TOP X 301 (-4.2A)NDP X 302 ( 3.8A)TOP X 301 (-3.0A)TOP X 301 (-4.8A)NoneNoneNoneNone | 0.45A | 1u70A-4g8zX:24.9 | 1u70A-4g8zX:36.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 7 | ILE A 9ALA A 11GLU A 32PRO A 63LEU A 69ARG A 72TYR A 118 | 14Q A 202 (-4.3A)14Q A 202 ( 3.7A)14Q A 202 (-2.8A)NoneNoneNoneNone | 0.71A | 1u70A-4h96A:21.2 | 1u70A-4h96A:35.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 7 | ILE A 9ALA A 11GLU A 32PRO A 63LEU A 69ARG A 72TYR A 127 | 14Q A 302 (-4.1A)14Q A 302 ( 3.4A)14Q A 302 (-2.8A)14Q A 302 (-4.4A)NoneNoneNone | 0.44A | 1u70A-4h98A:22.0 | 1u70A-4h98A:38.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jpd | PROTEIN CYAY (Burkholderiacenocepacia) |
PF01491(Frataxin_Cyay) | 5 | ILE A 51ALA A 65PHE A 44ASN A 25LEU A 33 | NoneNoneACT A 201 (-4.7A)NoneNone | 1.29A | 1u70A-4jpdA:undetectable | 1u70A-4jpdA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kk7 | ESX-1 SECRETIONSYSTEM PROTEIN ECCB1 (Mycobacteriumtuberculosis) |
PF05108(T7SS_ESX1_EccB) | 5 | ILE A 441ALA A 235GLN A 349PRO A 180LEU A 172 | None | 1.23A | 1u70A-4kk7A:undetectable | 1u70A-4kk7A:18.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m2x | DIHYDROFOLATEREDUCTASE (Mycobacteriumtuberculosis) |
PF00186(DHFR_1) | 6 | ILE A 5ALA A 7PRO A 51LEU A 57ARG A 60TYR A 100 | TMQ A 202 (-4.0A)TMQ A 202 ( 3.5A)TMQ A 202 (-4.2A)NoneNoneNone | 0.60A | 1u70A-4m2xA:20.2 | 1u70A-4m2xA:31.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 5 | ILE A 5ALA A 7LYS A 55ARG A 57TYR A 100 | MTX A 201 (-4.1A)MTX A 201 ( 4.0A)XCN A 54 ( 3.1A)MTX A 201 (-3.0A)None | 1.11A | 1u70A-4p68A:20.4 | 1u70A-4p68A:32.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qgr | DEGT/DNRJ/ERYC1/STRSAMINOTRANSFERASE (Brucellaabortus) |
PF01041(DegT_DnrJ_EryC1) | 5 | ILE A 309GLN A 359PRO A 277ASN A 267LEU A 270 | None | 1.17A | 1u70A-4qgrA:undetectable | 1u70A-4qgrA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rcn | LONG-CHAIN ACYL-COACARBOXYLASE (Mycobacteriumavium) |
PF00289(Biotin_carb_N)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ALA A1012ARG A1014PHE A1034LEU A 854TYR A 978 | None | 1.47A | 1u70A-4rcnA:undetectable | 1u70A-4rcnA:10.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um8 | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | ILE A 191ALA A 140PHE A 129GLN A 131TYR A 204 | None | 1.45A | 1u70A-4um8A:undetectable | 1u70A-4um8A:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj3 | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Pseudomonasaeruginosa) |
PF01425(Amidase) | 5 | ILE A 397GLN A 459PRO A 191LEU A 463TYR A 265 | None | 1.50A | 1u70A-4wj3A:undetectable | 1u70A-4wj3A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5byu | THIOESTERASE (Legionellapneumophila) |
PF13279(4HBT_2) | 5 | ILE A 77ALA A 103PHE A 32GLN A 36ARG A 39 | None | 1.41A | 1u70A-5byuA:undetectable | 1u70A-5byuA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 5 | ILE A 5ALA A 7LEU A 71ARG A 74TYR A 117 | NoneNAP A 201 (-3.7A)NoneNoneNone | 0.30A | 1u70A-5dxvA:12.5 | 1u70A-5dxvA:29.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f1y | MCCC FAMILY PROTEIN (Bacillus cereus) |
PF02016(Peptidase_S66) | 5 | ILE A 100ALA A 104GLN A 66PRO A 52ASN A 53 | None | 1.23A | 1u70A-5f1yA:undetectable | 1u70A-5f1yA:20.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fda | DIHYDROFOLATEREDUCTASE (Yersinia pestis) |
PF00186(DHFR_1) | 5 | ILE A 6ALA A 8LEU A 55ARG A 58TYR A 101 | None | 1.23A | 1u70A-5fdaA:14.6 | 1u70A-5fdaA:31.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gjv | VOLTAGE-DEPENDENTL-TYPE CALCIUMCHANNEL SUBUNITALPHA-1S (Oryctolaguscuniculus) |
PF00520(Ion_trans)PF08763(Ca_chan_IQ)PF16905(GPHH) | 5 | ILE A 822PHE A1306GLN A1311ASN A1304LEU A1294 | NoneNonePC1 A1915 (-3.7A)NoneNone | 1.45A | 1u70A-5gjvA:undetectable | 1u70A-5gjvA:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnw | BLR0248 PROTEIN (Bradyrhizobiumdiazoefficiens) |
no annotation | 5 | ALA C 134PHE C 80GLN C 78LEU C 69ARG C 42 | NoneNoneNoneURA C 301 (-3.9A)None | 1.35A | 1u70A-5gnwC:undetectable | 1u70A-5gnwC:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mll | DNA PROCESSING CHAINA (DPRA) (Helicobacterpylori) |
no annotation | 5 | ILE A 76ALA A 47ARG A 143PRO A 109ASN A 112 | None | 1.39A | 1u70A-5mllA:undetectable | 1u70A-5mllA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ocs | PUTATIVENADH-DEPENTDENTFLAVINOXIDOREDUCTASE (Cupriavidusmetallidurans) |
PF00724(Oxidored_FMN) | 5 | ILE A 172ALA A 164ARG A 219ASN A 12LEU A 13 | None | 1.43A | 1u70A-5ocsA:undetectable | 1u70A-5ocsA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohs | - (-) |
no annotation | 5 | ILE A 257ALA A 240ARG A 518GLN A 530ARG A 253 | None | 1.47A | 1u70A-5ohsA:undetectable | 1u70A-5ohsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | ALA A 10PHE A 32PRO A 88LEU A 94ARG A 97TYR A 157 | 73X A 704 (-4.0A)73X A 704 (-4.7A)73X A 704 (-4.0A)NoneNoneNone | 0.51A | 1u70A-5t0lA:23.8 | 1u70A-5t0lA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vgc | NLEG5-1 EFFECTOR (Enterobacteriaphage YYZ-2008) |
no annotation | 5 | ILE A 189ALA A 181GLN A 113ASN A 111LEU A 114 | None CL A 306 ( 4.6A)NoneNoneNone | 1.47A | 1u70A-5vgcA:undetectable | 1u70A-5vgcA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wa0 | PUTATIVE SULFITEOXIDASE (Sinorhizobiummeliloti) |
no annotation | 5 | ILE A 99ALA A 250PRO A 206ASN A 209LEU A 210 | None | 1.39A | 1u70A-5wa0A:undetectable | 1u70A-5wa0A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wtk | CRISPR-ASSOCIATEDENDORIBONUCLEASEC2C2 (Leptotrichiashahii) |
no annotation | 5 | ILE A 707ALA A 705PHE A 795ASN A 687LEU A 683 | None | 1.44A | 1u70A-5wtkA:undetectable | 1u70A-5wtkA:8.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byo | VOLTAGE-DEPENDENTL-TYPE CALCIUMCHANNEL SUBUNITALPHA-1S (Oryctolaguscuniculus) |
no annotation | 5 | ILE A 822PHE A1306GLN A1311ASN A1304LEU A1294 | None | 1.45A | 1u70A-6byoA:undetectable | 1u70A-6byoA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 6 | ILE A 6ALA A 8PRO A 52LEU A 58ARG A 61TYR A 98 | MMV A 202 (-4.0A)NAP A 201 (-3.9A)MMV A 202 ( 4.6A)MMV A 202 (-4.2A)MMV A 202 (-2.8A)None | 0.53A | 1u70A-6cxmA:19.8 | 1u70A-6cxmA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5u | ENVELOPEGLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1 (Zaireebolavirus) |
no annotation | 5 | ALA A 82GLU A 178PHE A 160LEU A 122TYR A 232 | None | 1.43A | 1u70A-6f5uA:undetectable | 1u70A-6f5uA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f6s | ENVELOPEGLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1 (Zaireebolavirus) |
no annotation | 5 | ALA A 82GLU A 178PHE A 160LEU A 122TYR A 232 | GOL A 506 ( 4.7A)GOL A 506 (-4.0A)NoneNoneNone | 1.38A | 1u70A-6f6sA:undetectable | 1u70A-6f6sA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ghs | 1,3-BETA-GLUCANASE (Hordeum vulgare) |
PF00332(Glyco_hydro_17) | 4 | SER A 181ILE A 180VAL A 193THR A 262 | None | 1.19A | 1u70A-1ghsA:0.2 | 1u70A-1ghsA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1he3 | BILIVERDIN IX BETAREDUCTASE (Homo sapiens) |
PF13460(NAD_binding_10) | 4 | SER A 202ILE A 176VAL A 149THR A 191 | None | 1.12A | 1u70A-1he3A:1.8 | 1u70A-1he3A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6u | UDP-N-ACETYLMURAMATE-ALANINE LIGASE MURC (Thermotogamaritima) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | SER A 435ILE A 431VAL A 343THR A 331 | None | 1.07A | 1u70A-1j6uA:4.2 | 1u70A-1j6uA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lq2 | BETA-D-GLUCANGLUCOHYDROLASEISOENZYME EXO1 (Hordeum vulgare) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 4 | SER A 524ILE A 523VAL A 541THR A 564 | None | 1.23A | 1u70A-1lq2A:undetectable | 1u70A-1lq2A:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrk | UDP-GLUCOSE4-EPIMERASE (Escherichiacoli) |
PF16363(GDP_Man_Dehyd) | 4 | SER A 171ILE A 172VAL A 77THR A 16 | None | 0.96A | 1u70A-1lrkA:0.8 | 1u70A-1lrkA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nff | PUTATIVEOXIDOREDUCTASERV2002 (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 4 | SER A 139ILE A 138VAL A 234THR A 201 | NoneNAD A1300 (-4.4A)NoneNone | 1.23A | 1u70A-1nffA:1.9 | 1u70A-1nffA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1n | HYPOTHETICALZINC-TYPE ALCOHOLDEHYDROGENASE-LIKEPROTEIN IN PRE5-FET4INTERGENIC REGION (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | SER A 295ILE A 296VAL A 249THR A 167 | None | 1.09A | 1u70A-1q1nA:1.8 | 1u70A-1q1nA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnh | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Plasmodiumfalciparum) |
PF00160(Pro_isomerase) | 4 | SER A 27ILE A 29VAL A 134THR A 122 | None | 1.18A | 1u70A-1qnhA:undetectable | 1u70A-1qnhA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqe | HYPOTHETICAL PROTEINPG130 (Staphylococcusaureus) |
PF03992(ABM) | 4 | SER A 110ILE A 108VAL A 67THR A 71 | None | 0.79A | 1u70A-1sqeA:undetectable | 1u70A-1sqeA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmr | ISOPULLULANASE (Aspergillusniger) |
PF03718(Glyco_hydro_49)PF17433(Glyco_hydro_49N) | 4 | SER A 113ILE A 112VAL A 74THR A 40 | None | 1.23A | 1u70A-1wmrA:undetectable | 1u70A-1wmrA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xg0 | B-PHYCOERYTHRIN BETACHAIN (Rhodomonas sp.CS24) |
PF00502(Phycobilisome) | 4 | SER C 32ILE C 31VAL C 41THR C 153 | NoneNoneNonePEB C 258 (-4.3A) | 1.21A | 1u70A-1xg0C:undetectable | 1u70A-1xg0C:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ytk | NICOTINATEPHOSPHORIBOSYLTRANSFERASE FROMTHERMOPLASMAACIDOPHILUM (Thermoplasmaacidophilum) |
PF01729(QRPTase_C) | 4 | SER A 296ILE A 295VAL A 163THR A 179 | NoneNoneNoneNCN A 401 (-3.1A) | 1.05A | 1u70A-1ytkA:undetectable | 1u70A-1ytkA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkp | HYPOTHETICAL PROTEINBA1088 (Bacillusanthracis) |
PF12706(Lactamase_B_2) | 4 | SER A 128ILE A 127VAL A 150THR A 210 | None | 1.21A | 1u70A-1zkpA:undetectable | 1u70A-1zkpA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ahw | PUTATIVE ENZYME YDIF (Escherichiacoli) |
PF01144(CoA_trans) | 4 | SER A 80ILE A 79VAL A 88THR A 158 | None | 1.22A | 1u70A-2ahwA:undetectable | 1u70A-2ahwA:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cyg | BETA-1, 3-GLUCANANSE (Musa acuminata) |
PF00332(Glyco_hydro_17) | 4 | SER A 215ILE A 214VAL A 228THR A 296 | None | 0.98A | 1u70A-2cygA:undetectable | 1u70A-2cygA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d6f | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT D (Methanothermobacterthermautotrophicus) |
PF00710(Asparaginase) | 4 | SER A 94ILE A 95VAL A 198THR A 183 | None | 1.15A | 1u70A-2d6fA:undetectable | 1u70A-2d6fA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9z | CHEMOTAXIS PROTEINCHEC (Thermotogamaritima) |
PF04509(CheC) | 4 | SER A 37ILE A 36VAL A 174THR A 82 | None | 1.25A | 1u70A-2f9zA:undetectable | 1u70A-2f9zA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwn | DIHYDROOROTASE (Porphyromonasgingivalis) |
PF01979(Amidohydro_1) | 4 | SER A 353ILE A 357VAL A 302THR A 255 | None | 1.18A | 1u70A-2gwnA:undetectable | 1u70A-2gwnA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h3g | BIOSYNTHETIC PROTEIN (Bacillusanthracis) |
PF03309(Pan_kinase) | 4 | SER X 228ILE X 227VAL X 128THR X 242 | None | 1.11A | 1u70A-2h3gX:undetectable | 1u70A-2h3gX:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsd | 3-ALPHA, 20BETA-HYDROXYSTEROIDDEHYDROGENASE (Streptomycesexfoliatus) |
PF13561(adh_short_C2) | 4 | SER A 138ILE A 137VAL A 239THR A 205 | NoneNAD A 256 (-4.6A)NoneNone | 1.14A | 1u70A-2hsdA:2.1 | 1u70A-2hsdA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mqa | MINOR AMPULLATEFIBROIN 1 (Nephilaantipodiana) |
PF12042(RP1-2) | 4 | SER A 112ILE A 111VAL A 58THR A 128 | None | 1.05A | 1u70A-2mqaA:undetectable | 1u70A-2mqaA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pod | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME (Burkholderiapseudomallei) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | SER A 221ILE A 247VAL A 266THR A 240 | None | 0.96A | 1u70A-2podA:undetectable | 1u70A-2podA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppv | UNCHARACTERIZEDPROTEIN (Staphylococcusepidermidis) |
PF01933(UPF0052) | 4 | SER A 281ILE A 283VAL A 273THR A 224 | None | 1.20A | 1u70A-2ppvA:1.8 | 1u70A-2ppvA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq6 | UDP-GLUCURONOSYL/UDP-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | SER A 251ILE A 252VAL A 223THR A 131 | None | 0.75A | 1u70A-2pq6A:undetectable | 1u70A-2pq6A:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v1u | CELL DIVISIONCONTROL PROTEIN 6HOMOLOG (Aeropyrumpernix) |
PF09079(Cdc6_C)PF13191(AAA_16) | 4 | SER A 310ILE A 311VAL A 385THR A 299 | None | 1.24A | 1u70A-2v1uA:undetectable | 1u70A-2v1uA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vt2 | REDOX-SENSINGTRANSCRIPTIONALREPRESSOR REX (Bacillussubtilis) |
PF02629(CoA_binding)PF06971(Put_DNA-bind_N) | 4 | SER A 114ILE A 113VAL A 148THR A 162 | None | 1.24A | 1u70A-2vt2A:2.2 | 1u70A-2vt2A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwb | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22)PF01163(RIO1) | 4 | SER A 379ILE A 376VAL A 192THR A 453 | None | 1.06A | 1u70A-2vwbA:undetectable | 1u70A-2vwbA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 4 | SER A1056ILE A1057VAL A1089THR A 972 | None | 1.21A | 1u70A-2vz9A:undetectable | 1u70A-2vz9A:6.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbe | BIPOLAR KINESINKRP-130 (Drosophilamelanogaster) |
PF00225(Kinesin) | 4 | SER C 145ILE C 144VAL C 227THR C 313 | None | 1.15A | 1u70A-2wbeC:undetectable | 1u70A-2wbeC:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wge | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 1 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | SER A 175ILE A 178VAL A 359THR A 32 | None | 1.00A | 1u70A-2wgeA:undetectable | 1u70A-2wgeA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0f | WSAF (Geobacillusstearothermophilus) |
no annotation | 4 | SER A 404ILE A 406VAL A 199THR A 217 | None | 1.03A | 1u70A-2x0fA:undetectable | 1u70A-2x0fA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3al0 | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT B (Thermotogamaritima) |
PF02637(GatB_Yqey)PF02934(GatB_N) | 4 | SER B 166ILE B 164VAL B 227THR B 262 | None | 1.23A | 1u70A-3al0B:undetectable | 1u70A-3al0B:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bz5 | INTERNALIN-J (Listeriamonocytogenes) |
PF12799(LRR_4) | 4 | SER A 103ILE A 105VAL A 75THR A 84 | None | 1.06A | 1u70A-3bz5A:undetectable | 1u70A-3bz5A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ch2 | SERINE-REPEATANTIGEN PROTEIN (Plasmodiumfalciparum) |
PF00112(Peptidase_C1) | 4 | SER X 816ILE X 814VAL X 764THR X 607 | None | 1.13A | 1u70A-3ch2X:undetectable | 1u70A-3ch2X:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckk | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Homo sapiens) |
PF02390(Methyltransf_4) | 4 | SER A 109ILE A 78VAL A 82THR A 208 | NoneSAM A 301 (-3.8A)NoneSAM A 301 (-2.8A) | 0.96A | 1u70A-3ckkA:undetectable | 1u70A-3ckkA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fyd | PROBABLEDIMETHYLADENOSINETRANSFERASE (Methanocaldococcusjannaschii) |
PF00398(RrnaAD) | 4 | SER A 107ILE A 110VAL A 98THR A 45 | None | 1.01A | 1u70A-3fydA:undetectable | 1u70A-3fydA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g2p | PCZA361.24 (Amycolatopsisorientalis) |
PF13649(Methyltransf_25) | 4 | SER A 139ILE A 142VAL A 268THR A 60 | None | 1.00A | 1u70A-3g2pA:undetectable | 1u70A-3g2pA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gaf | 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Brucellaabortus) |
PF13561(adh_short_C2) | 4 | SER A 145ILE A 144VAL A 246THR A 213 | None | 1.23A | 1u70A-3gafA:undetectable | 1u70A-3gafA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grk | ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE(NADH) (Brucellamelitensis) |
PF13561(adh_short_C2) | 4 | SER A 191ILE A 190VAL A 223THR A 197 | None | 1.21A | 1u70A-3grkA:undetectable | 1u70A-3grkA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gry | DIMETHYLADENOSINETRANSFERASE (Methanocaldococcusjannaschii) |
PF00398(RrnaAD) | 4 | SER A 107ILE A 110VAL A 98THR A 45 | None | 0.89A | 1u70A-3gryA:undetectable | 1u70A-3gryA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2u | KINESIN-LIKE PROTEINKLP10A (Drosophilamelanogaster) |
PF00225(Kinesin) | 4 | SER K 503ILE K 506VAL K 416THR K 404 | None | 1.25A | 1u70A-3j2uK:undetectable | 1u70A-3j2uK:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF11 (Schizosaccharomycespombe) |
PF13087(AAA_12)PF16399(Aquarius_N) | 4 | SER X1151ILE X1150VAL X1143THR X1100 | None | 1.01A | 1u70A-3jb9X:undetectable | 1u70A-3jb9X:9.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kkl | PROBABLE CHAPERONEPROTEIN HSP33 (Saccharomycescerevisiae) |
no annotation | 4 | SER A 9ILE A 8VAL A 101THR A 211 | None | 1.18A | 1u70A-3kklA:undetectable | 1u70A-3kklA:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l76 | ASPARTOKINASE (Synechocystissp. PCC 6803) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 4 | SER A 569ILE A 568VAL A 435THR A 198 | NoneLYS A 603 (-4.5A)NoneNone | 1.21A | 1u70A-3l76A:undetectable | 1u70A-3l76A:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1g | PUTATIVE GLUTATHIONES-TRANSFERASE (Corynebacteriumglutamicum) |
PF13409(GST_N_2)PF13410(GST_C_2) | 4 | SER A 87ILE A 86VAL A 147THR A 134 | None | 1.24A | 1u70A-3m1gA:undetectable | 1u70A-3m1gA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n23 | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 (Sus scrofa) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 4 | SER A 200ILE A 199VAL A 184THR A 240 | None | 1.10A | 1u70A-3n23A:undetectable | 1u70A-3n23A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nap | CAPSID PROTEIN (Triatoma virus) |
PF08762(CRPV_capsid) | 4 | SER A 238ILE A 237VAL A 253THR A 257 | None | 1.25A | 1u70A-3napA:undetectable | 1u70A-3napA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 4 | SER A 648ILE A 652VAL A 578THR A 544 | None | 1.25A | 1u70A-3nowA:undetectable | 1u70A-3nowA:12.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opy | 6-PHOSPHOFRUCTO-1-KINASE BETA-SUBUNIT (Komagataellapastoris) |
PF00365(PFK) | 4 | SER B 443ILE B 442VAL B 450THR B 426 | None | 1.18A | 1u70A-3opyB:undetectable | 1u70A-3opyB:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qat | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Bartonellahenselae) |
PF00698(Acyl_transf_1) | 4 | SER A 69ILE A 73VAL A 90THR A 273 | None | 1.00A | 1u70A-3qatA:undetectable | 1u70A-3qatA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qwn | HYPOTHETICALNIGD-LIKE PROTEIN (Bacteroidescaccae) |
PF12667(NigD_N)PF17415(NigD_C) | 4 | SER A 95ILE A 93VAL A 36THR A 101 | NoneNoneNone CL A 262 ( 4.3A) | 1.10A | 1u70A-3qwnA:undetectable | 1u70A-3qwnA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3svt | SHORT-CHAIN TYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumulcerans) |
PF13561(adh_short_C2) | 4 | SER A 146ILE A 145VAL A 248THR A 215 | None | 1.18A | 1u70A-3svtA:undetectable | 1u70A-3svtA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sx2 | PUTATIVE3-KETOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 4 | SER A 155ILE A 154VAL A 206THR A 216 | NoneNAD A 300 (-4.7A)NAD A 300 (-4.1A)None | 1.17A | 1u70A-3sx2A:undetectable | 1u70A-3sx2A:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsn | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Campylobacterjejuni) |
PF04166(PdxA) | 4 | SER A 7ILE A 6VAL A 330THR A 334 | None | 1.05A | 1u70A-3tsnA:undetectable | 1u70A-3tsnA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vf1 | 11R-LIPOXYGENASE (Gersemiafruticosa) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | SER A 22ILE A 23VAL A 114THR A 130 | None | 1.09A | 1u70A-3vf1A:undetectable | 1u70A-3vf1A:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0s | OCTENOYL-COAREDUCTASE/CARBOXYLASE (Streptomycescinnabarigriseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | SER A 235ILE A 238VAL A 252THR A 318 | NoneNoneNAP A1447 (-3.8A)None | 1.20A | 1u70A-4a0sA:2.2 | 1u70A-4a0sA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a7p | UDP-GLUCOSEDEHYDROGENASE (Sphingomonaselodea) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 4 | SER A 338ILE A 340VAL A 387THR A 430 | None | 1.18A | 1u70A-4a7pA:undetectable | 1u70A-4a7pA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btg | MAJOR INNER PROTEINP1 (Pseudomonasvirus phi6) |
no annotation | 4 | SER A 539ILE A 535VAL A 31THR A 17 | None | 1.02A | 1u70A-4btgA:undetectable | 1u70A-4btgA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e13 | DIKETOREDUCTASE (Acinetobacterbaylyi) |
PF00725(3HCDH)PF02737(3HCDH_N) | 4 | SER A 248ILE A 247VAL A 239THR A 276 | 1PE A 306 (-3.1A)1PE A 306 ( 3.9A)1PE A 306 (-4.6A)None | 1.19A | 1u70A-4e13A:undetectable | 1u70A-4e13A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f6l | AUSA REDUCTASEDOMAIN PROTEIN (Staphylococcusaureus) |
no annotation | 4 | SER B2171ILE B2226VAL B2193THR B2187 | None | 1.13A | 1u70A-4f6lB:undetectable | 1u70A-4f6lB:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvl | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N) | 4 | SER A 304ILE A 306VAL A 519THR A 537 | None | 0.97A | 1u70A-4gvlA:2.5 | 1u70A-4gvlA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iis | BETA-1,3-GLUCANASEFORM 'RRII GLN 2' (Heveabrasiliensis) |
PF00332(Glyco_hydro_17) | 4 | SER A 191ILE A 190VAL A 204THR A 271 | None | 1.04A | 1u70A-4iisA:undetectable | 1u70A-4iisA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnd | CA(2+)/CALMODULIN-DEPENDENT PROTEINKINASE PHOSPHATASE (Caenorhabditiselegans) |
PF00481(PP2C) | 4 | SER A 401ILE A 404VAL A 417THR A 263 | None | 1.24A | 1u70A-4jndA:undetectable | 1u70A-4jndA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mow | GLUCOSE1-DEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 4 | SER A 140ILE A 139VAL A 243THR A 210 | None | 1.16A | 1u70A-4mowA:undetectable | 1u70A-4mowA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbt | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Acholeplasmalaidlawii) |
PF13561(adh_short_C2) | 4 | SER A 132ILE A 131VAL A 234THR A 201 | NoneNAD A 301 (-3.9A)NoneNone | 1.15A | 1u70A-4nbtA:undetectable | 1u70A-4nbtA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4odi | PHOSPHOGLYCERATEMUTASE PGMII (Toxoplasmagondii) |
PF00300(His_Phos_1) | 4 | SER A 187ILE A 188VAL A 196THR A 89 | None | 1.14A | 1u70A-4odiA:1.7 | 1u70A-4odiA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okm | TERPENE SYNTHASEMETAL-BINDINGDOMAIN-CONTAININGPROTEIN (Streptomycespristinaespiralis) |
no annotation | 4 | SER A 322ILE A 306VAL A 7THR A 329 | None | 1.24A | 1u70A-4okmA:undetectable | 1u70A-4okmA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q34 | UNCHARACTERIZEDPROTEIN (Parabacteroidesdistasonis) |
PF12697(Abhydrolase_6) | 4 | SER A 215ILE A 262VAL A 222THR A 237 | None | 1.13A | 1u70A-4q34A:undetectable | 1u70A-4q34A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rer | 5'-AMP-ACTIVATEDPROTEIN KINASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00571(CBS) | 4 | SER G 54ILE G 114VAL G 83THR G 163 | None | 1.19A | 1u70A-4rerG:undetectable | 1u70A-4rerG:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4umg | PROTEIN LIN-41 (Caenorhabditiselegans) |
PF00630(Filamin) | 4 | SER A 699ILE A 808VAL A 785THR A 714 | None | 1.06A | 1u70A-4umgA:undetectable | 1u70A-4umgA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wuv | 2-HYDROXYCYCLOHEXANECARBOXYL-COADEHYDROGENASE (Haemophilusinfluenzae) |
PF00106(adh_short) | 4 | SER A 167ILE A 166VAL A 275THR A 241 | NoneNAD A 301 (-3.9A)NoneNone | 1.16A | 1u70A-4wuvA:undetectable | 1u70A-4wuvA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1b | ANTE (Streptomycessp. NRRL 2288) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | SER A 216ILE A 219VAL A 233THR A 306 | NoneNoneNAP A 501 (-3.9A)NAP A 501 (-3.9A) | 1.04A | 1u70A-4y1bA:2.2 | 1u70A-4y1bA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | SER A 282ILE A 281VAL A 389THR A 513 | None | 1.08A | 1u70A-4ydqA:undetectable | 1u70A-4ydqA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c41 | RIBOKINASE (Homo sapiens) |
PF00294(PfkB) | 4 | SER A 94ILE A 93VAL A 20THR A 159 | None | 1.23A | 1u70A-5c41A:undetectable | 1u70A-5c41A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cef | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Cryptococcusneoformans) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | SER A 208ILE A 207VAL A 194THR A 17 | None | 0.91A | 1u70A-5cefA:undetectable | 1u70A-5cefA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dzs | SHIKIMATEDEHYDROGENASE(NADP(+)) (Clostridioidesdifficile) |
PF08501(Shikimate_dh_N) | 4 | SER A 243ILE A 246VAL A 85THR A 135 | None | 1.10A | 1u70A-5dzsA:2.0 | 1u70A-5dzsA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ejs | MYOSIN-I HEAVY CHAIN (Dictyosteliumdiscoideum) |
PF00373(FERM_M)PF00784(MyTH4)PF09380(FERM_C) | 4 | SER A2099ILE A2100VAL A2144THR A2273 | None | 1.25A | 1u70A-5ejsA:undetectable | 1u70A-5ejsA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5flz | TUBULIN GAMMA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 4 | SER C 262ILE C 260VAL C 318THR C 382 | None | 1.23A | 1u70A-5flzC:undetectable | 1u70A-5flzC:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fr8 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | SER A 131ILE A 129VAL A 96THR A 92 | None | 1.01A | 1u70A-5fr8A:undetectable | 1u70A-5fr8A:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsw | RNA DEPENDENT RNAPOLYMERASE QDE-1 (Thielaviaterrestris) |
PF05183(RdRP) | 4 | SER A 590ILE A 592VAL A 721THR A 708 | None | 1.23A | 1u70A-5fswA:undetectable | 1u70A-5fswA:10.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iob | BETA-GLUCOSIDASE-RELATED GLYCOSIDASES (Corynebacteriumglutamicum) |
PF00933(Glyco_hydro_3) | 4 | SER A 358ILE A 360VAL A 79THR A 318 | None | 1.13A | 1u70A-5iobA:undetectable | 1u70A-5iobA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iv9 | LPS-ASSEMBLYLIPOPROTEIN LPTELPS-ASSEMBLY PROTEINLPTD (Klebsiellapneumoniae) |
PF03968(OstA)PF04390(LptE)PF04453(OstA_C) | 4 | SER B 81ILE B 82VAL B 122THR A 614 | None | 1.04A | 1u70A-5iv9B:undetectable | 1u70A-5iv9B:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jod | PROPLASMEPSIN IV (Plasmodiumfalciparum) |
PF00026(Asp) | 4 | SER A 278ILE A 280VAL A 246THR A 219 | None | 1.24A | 1u70A-5jodA:undetectable | 1u70A-5jodA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kk5 | CRISPR-ASSOCIATEDENDONUCLEASE CPF1 (Acidaminococcussp. BV3L6) |
no annotation | 4 | SER A 778ILE A 779VAL A1027THR A1046 | None | 1.02A | 1u70A-5kk5A:undetectable | 1u70A-5kk5A:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkt | RENIN-1 (Mus musculus) |
no annotation | 4 | SER A 236ILE A 235VAL A 265THR A 56 | None | 1.25A | 1u70A-5mktA:undetectable | 1u70A-5mktA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqc | VP1VP3 (Black queencell virus) |
PF08762(CRPV_capsid)no annotation | 4 | SER C 119ILE C 117VAL A 109THR C 22 | None | 1.25A | 1u70A-5mqcC:undetectable | 1u70A-5mqcC:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tge | PHAGE TERMINASELARGE SUBUNIT (Thermus virusP74-26) |
PF17289(Terminase_6C) | 4 | SER A 382ILE A 381VAL A 371THR A 367 | None | 1.07A | 1u70A-5tgeA:undetectable | 1u70A-5tgeA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uja | BOVINE MULTIDRUGRESISTANCE PROTEIN 1(MRP1),MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 4 | SER A 604ILE A 603VAL A 477THR A 556 | None | 1.16A | 1u70A-5ujaA:undetectable | 1u70A-5ujaA:8.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 4 | SER A 161ILE A 162VAL A 127THR A 143 | None | 1.10A | 1u70A-5um6A:undetectable | 1u70A-5um6A:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vad | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | SER A1044ILE A1043VAL A1151THR A1277 | None | 1.16A | 1u70A-5vadA:undetectable | 1u70A-5vadA:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x33 | LTB4RECEPTOR,LYSOZYME,LTB4 RECEPTOR (Caviaporcellus;Escherichiavirus T4) |
no annotation | 4 | SER A 202ILE A 206VAL A 226THR A 55 | None | 1.20A | 1u70A-5x33A:undetectable | 1u70A-5x33A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgc | RAP1 GTPASE-GDPDISSOCIATIONSTIMULATOR 1 (Homo sapiens) |
PF00514(Arm) | 4 | SER A 422ILE A 425VAL A 398THR A 355 | None | 1.24A | 1u70A-5xgcA:undetectable | 1u70A-5xgcA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xio | PROLINE-TRNASYNTHETASE CLASS IIAARS (YBAK RNABINDING DOMAIN PLUSTRNA SYNTHETASE) (Cryptosporidiumparvum) |
no annotation | 4 | SER A 254ILE A 253VAL A 361THR A 485 | None | 1.09A | 1u70A-5xioA:undetectable | 1u70A-5xioA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xip | PROLYL-TRNASYNTHETASE, PUTATIVE (Eimeria tenella) |
no annotation | 4 | SER A 282ILE A 281VAL A 389THR A 513 | None | 1.17A | 1u70A-5xipA:undetectable | 1u70A-5xipA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwq | FUNGAL CHITINASEFROM RHIZOMUCORMIEHEI (NATIVEPROTEIN) (Rhizomucormiehei) |
no annotation | 4 | SER A 385ILE A 384VAL A 281THR A 316 | None | 1.11A | 1u70A-5xwqA:undetectable | 1u70A-5xwqA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yb7 | L-AMINO ACIDOXIDASE/MONOOXYGENASE (Pseudomonas sp.AIU 813) |
no annotation | 4 | SER A 106ILE A 15VAL A 250THR A 232 | None | 1.19A | 1u70A-5yb7A:undetectable | 1u70A-5yb7A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c3p | ATP-BINDING CASSETTESUB-FAMILY C MEMBER8 (Homo sapiens) |
no annotation | 4 | SER E1422ILE E1423VAL E1533THR E1541 | None | 1.21A | 1u70A-6c3pE:undetectable | 1u70A-6c3pE:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f45 | - (-) |
no annotation | 4 | SER D 38ILE D 37VAL D 30THR D 73 | None | 1.18A | 1u70A-6f45D:undetectable | 1u70A-6f45D:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fah | CAFFEYL-COAREDUCTASE-ETFCOMPLEX SUBUNIT CARDCAFFEYL-COAREDUCTASE-ETFCOMPLEX SUBUNIT CARE (Acetobacteriumwoodii) |
no annotation | 4 | SER A 145ILE A 148VAL A 179THR B 95 | NoneNoneNoneFAD B 301 (-2.7A) | 0.99A | 1u70A-6fahA:2.2 | 1u70A-6fahA:19.88 |