SIMILAR PATTERNS OF AMINO ACIDS FOR 1U1J_A_C2FA773

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 ARG A 247
SER A 242
ARG A  88
VAL A 245
 None
 1.08A 1u1jA-1a0pA:
undetectable		 1u1jA-1a0pA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 4 ARG A 120
HIS A  34
SER A  33
VAL A 121
 PO4  A 400 ( 3.8A)
None
None
None
 1.19A 1u1jA-1aqzA:
undetectable		 1u1jA-1aqzA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cd1 CD1

(Mus musculus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 ARG A 204
HIS A 209
SER A 194
VAL A 196
 None
 1.27A 1u1jA-1cd1A:
undetectable		 1u1jA-1cd1A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 ARG A 521
ASN A 449
VAL A 518
TRP A 452
 None
 1.27A 1u1jA-1fftA:
undetectable		 1u1jA-1fftA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ARG A1270
ASN A1276
SER A1272
ARG A1320
 None
 1.30A 1u1jA-1fnfA:
undetectable		 1u1jA-1fnfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxm GAMMA-DELTA T-CELL
RECEPTOR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS A 179
HIS A 201
SER A 192
VAL A 155
 None
 1.12A 1u1jA-1hxmA:
undetectable		 1u1jA-1hxmA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ARG A 637
ASN A 230
HIS A 206
VAL A 636
 None
 1.36A 1u1jA-1kehA:
undetectable		 1u1jA-1kehA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LYS A  28
ASN A  83
SER A  88
VAL A  90
 None
 1.26A 1u1jA-1ksiA:
undetectable		 1u1jA-1ksiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 ARG A  42
HIS A  14
SER A   9
ARG A   3
 None
 1.26A 1u1jA-1l0wA:
undetectable		 1u1jA-1l0wA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n2o PANTOTHENATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF02569
(Pantoate_ligase) 		4 LYS A  83
ASN A 199
HIS A  44
SER A 197
 None
None
SO4  A 601 (-3.9A)
SO4  A 601 (-3.0A)
 1.15A 1u1jA-1n2oA:
2.2		 1u1jA-1n2oA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oah CYTOCHROME C NITRITE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF02335
(Cytochrom_C552) 		4 HIS A 387
SER A 290
ARG A 412
TRP A 285
 None
 1.33A 1u1jA-1oahA:
undetectable		 1u1jA-1oahA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p22 F-BOX/WD-REPEAT
PROTEIN 1A

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		4 ARG A 285
HIS A 518
SER A 536
ARG A 521
 SEP  C  33 ( 3.7A)
None
None
None
 1.14A 1u1jA-1p22A:
undetectable		 1u1jA-1p22A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 ARG A 203
LYS A 202
SER A 196
VAL A 454
 None
 1.31A 1u1jA-1pemA:
2.2		 1u1jA-1pemA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  15
LYS A  18
ASN A 116
HIS A 118
SER A 517
VAL A 523
TRP A 567
 None
 0.33A 1u1jA-1u1hA:
66.4		 1u1jA-1u1hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  18
ASN A 116
HIS A 118
SER A 517
ARG A 521
 None
 1.24A 1u1jA-1u1hA:
66.4		 1u1jA-1u1hA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ASN A 108
HIS A  83
SER A 112
VAL A 155
 None
 1.33A 1u1jA-1ulsA:
2.1		 1u1jA-1ulsA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4

(Homo sapiens) 		PF00169
(PH) 		4 ARG A1075
LYS A1063
SER A1098
ARG A1129
 4IP  A2154 (-3.6A)
4IP  A2154 (-2.5A)
None
4IP  A2154 (-2.5A)
 1.20A 1u1jA-1uprA:
undetectable		 1u1jA-1uprA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ARG A 337
SER A 361
ARG A 360
VAL A 345
 None
 1.23A 1u1jA-1uypA:
undetectable		 1u1jA-1uypA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 ARG A 383
ASN A 388
ARG A 335
TRP A 390
 None
 1.29A 1u1jA-1uz4A:
11.8		 1u1jA-1uz4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 ASN B  85
HIS B  81
SER B 230
VAL B 186
 None
PLP  B 400 (-3.9A)
PLP  B 400 (-2.7A)
None
 1.36A 1u1jA-1wdwB:
undetectable		 1u1jA-1wdwB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 ARG A  44
ASN A  64
SER A  66
ARG A  95
 None
 0.75A 1u1jA-1wzcA:
undetectable		 1u1jA-1wzcA:
15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  15
LYS A  18
ASN A 109
HIS A 111
SER A 489
ARG A 493
TRP A 539
 C2F  A1882 ( 4.6A)
C2F  A1882 (-2.4A)
C2F  A1882 (-3.7A)
None
C2F  A1882 (-3.0A)
C2F  A1882 ( 3.5A)
C2F  A1882 (-3.7A)
 0.86A 1u1jA-1xpgA:
47.5		 1u1jA-1xpgA:
41.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z01 2-OXO-1,2-DIHYDROQUI
NOLINE
8-MONOOXYGENASE,
OXYGENASE COMPONENT

(Pseudomonas
putida) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ARG A 290
HIS A 199
ARG A 348
VAL A 312
 None
 1.35A 1u1jA-1z01A:
undetectable		 1u1jA-1z01A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 ASN 3 104
HIS 3  96
SER 3  95
ARG 3  93
 None
 1.30A 1u1jA-1z7z3:
undetectable		 1u1jA-1z7z3:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 ARG A 198
HIS A 193
ARG A 164
VAL A 117
 PLP  A 419 (-2.9A)
None
None
None
 1.27A 1u1jA-2a5hA:
4.8		 1u1jA-2a5hA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		4 HIS A 188
SER A 191
ARG A 193
VAL A 161
 None
 1.31A 1u1jA-2a9jA:
undetectable		 1u1jA-2a9jA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cql 60S RIBOSOMAL
PROTEIN L9

(Homo sapiens) 		PF00347
(Ribosomal_L6) 		4 ASN A  79
HIS A  76
SER A  75
ARG A  71
 None
 0.80A 1u1jA-2cqlA:
undetectable		 1u1jA-2cqlA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		4 ARG A 245
HIS A 204
ARG A 243
VAL A 134
 None
 1.33A 1u1jA-2cu2A:
undetectable		 1u1jA-2cu2A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 770
ASN A 726
ARG A 734
VAL A 768
 None
 1.01A 1u1jA-2f3oA:
undetectable		 1u1jA-2f3oA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 ARG A  92
HIS A 107
SER A  75
VAL A  87
 None
FE2  A1326 ( 3.4A)
None
None
 1.02A 1u1jA-2ivpA:
undetectable		 1u1jA-2ivpA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kh2 SCFV

(Mus musculus) 		PF07686
(V-set) 		4 ARG B 227
ASN B 203
SER B 159
ARG B 160
 None
 1.01A 1u1jA-2kh2B:
undetectable		 1u1jA-2kh2B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls8 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ARG A  56
ASN A 114
SER A  59
ARG A  57
 None
 1.19A 1u1jA-2ls8A:
undetectable		 1u1jA-2ls8A:
10.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  16
ASN A 115
HIS A 117
SER A 500
ARG A 504
VAL A 506
TRP A 550
 None
 0.90A 1u1jA-2nq5A:
50.7		 1u1jA-2nq5A:
46.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  16
LYS A  19
ASN A 115
HIS A 117
ARG A 504
VAL A 506
TRP A 550
 None
 0.75A 1u1jA-2nq5A:
50.7		 1u1jA-2nq5A:
46.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		4 ARG A  35
ASN A 115
HIS A  58
SER A  45
 None
 1.05A 1u1jA-2o61A:
undetectable		 1u1jA-2o61A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v14 KINESIN-LIKE MOTOR
PROTEIN C20ORF23

(Homo sapiens) 		PF00787
(PX) 		4 ARG A1261
ARG A1269
VAL A1206
TRP A1215
 None
 1.35A 1u1jA-2v14A:
undetectable		 1u1jA-2v14A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ARG A 116
ASN A  86
SER A  88
ARG A  90
 None
 1.20A 1u1jA-2x2iA:
7.7		 1u1jA-2x2iA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 LYS A   5
HIS A 202
SER A 206
VAL A 210
 SO4  A 401 ( 4.3A)
None
None
None
 1.35A 1u1jA-2zzrA:
undetectable		 1u1jA-2zzrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4r UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF06254
(YdaT_toxin) 		4 HIS A  95
SER A  94
ARG A  93
VAL A 104
 None
 1.27A 1u1jA-3c4rA:
undetectable		 1u1jA-3c4rA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d19 CONSERVED
METALLOPROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 ARG A 236
HIS A  37
ARG A  32
VAL A 256
 None
FE  A 302 (-3.4A)
None
None
 1.34A 1u1jA-3d19A:
undetectable		 1u1jA-3d19A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1b TETR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 ARG A 112
HIS A 103
SER A 106
VAL A  22
 None
SO4  A 204 (-4.2A)
None
None
 1.34A 1u1jA-3f1bA:
undetectable		 1u1jA-3f1bA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ARG A 224
ASN A 273
SER A 268
ARG A 270
 None
None
None
PO4  A 556 ( 4.8A)
 1.23A 1u1jA-3gdeA:
undetectable		 1u1jA-3gdeA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A1190
ASN A1227
SER A1209
VAL A1234
 None
 1.25A 1u1jA-3greA:
undetectable		 1u1jA-3greA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Vibrio
parahaemolyticus) 		PF00106
(adh_short) 		4 ARG A 115
LYS A 114
ARG A 110
VAL A  60
 None
 1.33A 1u1jA-3guyA:
3.7		 1u1jA-3guyA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ARG A 284
ASN A 287
ARG A  40
VAL A 282
 None
CSJ  A 112 ( 3.8A)
None
None
 1.11A 1u1jA-3h77A:
undetectable		 1u1jA-3h77A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens) 		PF04437
(RINT1_TIP1) 		4 HIS A 632
SER A 694
VAL A 690
TRP A 648
 None
 1.16A 1u1jA-3hr0A:
undetectable		 1u1jA-3hr0A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr6 PUTATIVE
SURFACE-ANCHORED
FIMBRIAL SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 4 ARG A 351
HIS A 418
SER A 354
VAL A 352
 None
IOD  A 487 (-4.7A)
None
None
 1.11A 1u1jA-3hr6A:
undetectable		 1u1jA-3hr6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 HIS A 286
SER A 289
ARG A 288
VAL A  68
 None
 1.26A 1u1jA-3hxwA:
3.0		 1u1jA-3hxwA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 LYS A 860
ASN A 850
SER A 853
VAL A 747
 None
 1.18A 1u1jA-3j3iA:
undetectable		 1u1jA-3j3iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ARG A 410
ASN A 321
SER A 377
ARG A 436
 None
 1.05A 1u1jA-3kmuA:
undetectable		 1u1jA-3kmuA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 321
SER A 377
ARG A 436
VAL A 356
 None
 1.31A 1u1jA-3kmuA:
undetectable		 1u1jA-3kmuA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 ARG A  80
SER A  64
VAL A  14
TRP A 321
 None
 1.36A 1u1jA-3myoA:
6.4		 1u1jA-3myoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nh9 ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
6, MITOCHONDRIAL

(Homo sapiens) 		PF00005
(ABC_tran) 		4 HIS A 665
SER A 661
ARG A 663
VAL A 657
 None
 1.35A 1u1jA-3nh9A:
undetectable		 1u1jA-3nh9A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE
DIHEME CYTOCHROME C
NAPB

(Cupriavidus
necator;
Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF03892
(NapB) 		4 HIS A 698
SER A 714
ARG A 713
VAL B 103
 None
 1.21A 1u1jA-3o5aA:
undetectable		 1u1jA-3o5aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omx CG14216

(Drosophila
melanogaster) 		PF04722
(Ssu72) 		4 ARG A  42
ASN A  16
SER A  15
VAL A  43
 None
None
VO4  A 300 (-4.0A)
None
 1.28A 1u1jA-3omxA:
undetectable		 1u1jA-3omxA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c ABL INTERACTOR 2

(Homo sapiens) 		PF07815
(Abi_HHR) 		4 ARG F  84
HIS F  92
SER F  88
ARG F  85
 None
 1.27A 1u1jA-3p8cF:
undetectable		 1u1jA-3p8cF:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  16
LYS A  19
ASN A 126
HIS A 128
SER A 526
VAL A 532
TRP A 576
 None
 0.47A 1u1jA-3ppcA:
53.2		 1u1jA-3ppcA:
49.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		4 ARG A 223
SER A 221
ARG A 175
VAL A 224
 None
 1.15A 1u1jA-3pzlA:
undetectable		 1u1jA-3pzlA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsc CALG2

(Micromonospora
echinospora) 		PF04101
(Glyco_tran_28_C) 		4 ARG A  45
HIS A   3
SER A  33
VAL A  52
 None
 1.29A 1u1jA-3rscA:
3.0		 1u1jA-3rscA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo sapiens) 		PF00041
(fn3) 		4 ARG A1392
ASN A1398
SER A1394
ARG A1442
 None
 1.21A 1u1jA-3t1wA:
undetectable		 1u1jA-3t1wA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		4 ARG A 115
HIS A 124
SER A 120
ARG A 122
 None
 1.36A 1u1jA-3uetA:
7.0		 1u1jA-3uetA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		4 ARG A 234
SER A 205
ARG A  22
VAL A 211
 None
 1.19A 1u1jA-3uetA:
7.0		 1u1jA-3uetA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		4 ASN A 451
SER A 447
ARG A 443
VAL A 457
 None
 0.97A 1u1jA-3vh1A:
2.2		 1u1jA-3vh1A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 ASN A 180
SER A 176
ARG A 172
VAL A 158
 None
 0.99A 1u1jA-3wecA:
undetectable		 1u1jA-3wecA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		4 ARG A 238
ASN A  16
HIS A 114
VAL A 236
 None
 1.13A 1u1jA-3zxyA:
2.2		 1u1jA-3zxyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Pyrococcus
furiosus) 		PF00697
(PRAI) 		4 ARG A 152
SER A 147
ARG A 145
VAL A 150
 None
 1.20A 1u1jA-4aajA:
10.1		 1u1jA-4aajA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 ASN A 677
SER A 673
ARG A 669
VAL A 734
 None
 1.19A 1u1jA-4bevA:
undetectable		 1u1jA-4bevA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 HIS A 438
SER A 436
ARG A 440
VAL A 442
 None
 1.18A 1u1jA-4bh6A:
undetectable		 1u1jA-4bh6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cby HISTONE DEACETYLASE
4

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 ASN A 816
HIS A 715
ARG A 772
VAL A 775
 None
 1.33A 1u1jA-4cbyA:
undetectable		 1u1jA-4cbyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		4 HIS B 245
ARG B 239
VAL B  43
TRP B  35
 None
 1.26A 1u1jA-4di4B:
undetectable		 1u1jA-4di4B:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 622
ASN A 628
SER A 631
VAL A 633
 None
 1.30A 1u1jA-4epaA:
undetectable		 1u1jA-4epaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ARG A 205
ASN A  58
SER A 387
VAL A  56
 None
 1.23A 1u1jA-4f4cA:
undetectable		 1u1jA-4f4cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 LYS A 211
HIS A 116
SER A 104
VAL A 102
 None
 1.17A 1u1jA-4faiA:
undetectable		 1u1jA-4faiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I

(Hordeum vulgare) 		PF00161
(RIP) 		4 ARG A  39
SER A  45
ARG A  48
VAL A  50
 None
 1.29A 1u1jA-4fbhA:
undetectable		 1u1jA-4fbhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		4 ARG A 403
LYS A 406
HIS A 181
SER A 213
 None
 1.35A 1u1jA-4fgmA:
undetectable		 1u1jA-4fgmA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		4 ARG A 575
HIS A  52
ARG A 582
VAL A 538
 None
None
ATP  A 702 ( 4.3A)
None
 1.18A 1u1jA-4fo0A:
undetectable		 1u1jA-4fo0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k92 CLIP-ASSOCIATING
PROTEIN 1

(Homo sapiens) 		PF12348
(CLASP_N) 		4 ARG A 462
ASN A 452
SER A 455
VAL A 460
 None
 1.11A 1u1jA-4k92A:
undetectable		 1u1jA-4k92A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01423
(LSM)
PF01423
(LSM) 		4 ASN D  25
HIS E  67
SER D  82
ARG E  70
 None
 1.30A 1u1jA-4m75D:
undetectable		 1u1jA-4m75D:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 ARG A 129
ASN A 220
HIS A 222
ARG A 184
 None
 1.34A 1u1jA-4n7tA:
undetectable		 1u1jA-4n7tA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbg TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE

(Janthinobacterium
sp. J3) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ASN A 170
HIS A 294
SER A 169
VAL A 341
 None
 1.36A 1u1jA-4nbgA:
undetectable		 1u1jA-4nbgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb9 AB64 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG H  13
ASN H  82
HIS H  81
SER H  17
 None
 1.30A 1u1jA-4pb9H:
undetectable		 1u1jA-4pb9H:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 ARG A 336
LYS A 328
HIS A  66
TRP A 227
 None
None
2M7  A 505 (-4.0A)
None
 1.33A 1u1jA-4pcsA:
9.9		 1u1jA-4pcsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq0 FACT COMPLEX SUBUNIT
POB3

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ARG A 284
HIS A 296
SER A 287
VAL A 369
 None
 1.24A 1u1jA-4pq0A:
undetectable		 1u1jA-4pq0A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc8 VP2

(Ungulate
bocaparvovirus
1) 		PF00740
(Parvo_coat) 		4 ARG A 125
HIS A 532
ARG A 123
VAL A 484
 None
 1.36A 1u1jA-4qc8A:
undetectable		 1u1jA-4qc8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A2801
HIS A2719
SER A2803
VAL A2800
 None
 1.36A 1u1jA-4qyrA:
undetectable		 1u1jA-4qyrA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B

(Methylobacterium
extorquens) 		PF12706
(Lactamase_B_2) 		4 ARG A  37
HIS A  93
SER A  40
VAL A 264
 None
ZN  A 302 ( 4.6A)
None
None
 1.20A 1u1jA-4z7rA:
undetectable		 1u1jA-4z7rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 ARG A 440
HIS A 139
ARG A 141
VAL A 336
 None
 1.23A 1u1jA-4zajA:
2.6		 1u1jA-4zajA:
23.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 ARG A  16
LYS A  19
HIS A 122
SER A 521
VAL A 527
TRP A 571
 None
 0.44A 1u1jA-4ztxA:
53.2		 1u1jA-4ztxA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 ARG A 210
HIS A 217
SER A 215
ARG A 234
 None
 1.05A 1u1jA-5b4wA:
undetectable		 1u1jA-5b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ARG A 169
HIS A 245
SER A 283
VAL A 166
 PO4  A 301 (-4.6A)
None
None
None
 1.29A 1u1jA-5ej2A:
2.2		 1u1jA-5ej2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ARG A 231
ASN A 154
ARG A 193
VAL A 152
 None
 1.34A 1u1jA-5f75A:
undetectable		 1u1jA-5f75A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 ARG A 367
LYS A 371
ASN A 144
SER A 105
 None
None
EDO  A1392 (-3.9A)
None
 1.26A 1u1jA-5fipA:
9.1		 1u1jA-5fipA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koa CELL DIVISION
PROTEIN ZAPD

(Escherichia
coli) 		PF07072
(ZapD) 		4 HIS A  37
ARG A  45
VAL A 121
TRP A 142
 None
 1.34A 1u1jA-5koaA:
undetectable		 1u1jA-5koaA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu2 14-3-3 PROTEIN SIGMA

(Homo sapiens) 		PF00244
(14-3-3) 		4 ARG A 117
ASN A 166
SER A 158
VAL A 118
 None
 1.22A 1u1jA-5lu2A:
undetectable		 1u1jA-5lu2A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 4 ARG A 181
HIS A 136
ARG A 245
VAL A 180
 None
 1.36A 1u1jA-5mkmA:
undetectable		 1u1jA-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ARG A 317
ASN A 339
SER A 340
ARG A 319
 None
None
None
GTR  A 608 (-3.0A)
 1.35A 1u1jA-5olsA:
undetectable		 1u1jA-5olsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 LYS C 114
ASN C 434
SER C 669
ARG C 664
 None
 1.27A 1u1jA-5tw1C:
undetectable		 1u1jA-5tw1C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASN A 451
HIS A 509
SER A 511
VAL A 453
 None
 1.23A 1u1jA-5vrbA:
undetectable		 1u1jA-5vrbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w66 RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN7

(Saccharomyces
cerevisiae) 		no annotation 4 ARG P 289
LYS P 240
ASN P 228
HIS P 301
 None
 1.20A 1u1jA-5w66P:
undetectable		 1u1jA-5w66P:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus;
Rattus
norvegicus) 		no annotation
no annotation 		4 ARG 7  85
HIS 1 110
SER 1 146
VAL 1 154
 None
 1.31A 1u1jA-6epd7:
undetectable		 1u1jA-6epd7:
undetectable