SIMILAR PATTERNS OF AMINO ACIDS FOR 1U18_B_HSMB402_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1em9 | GAG POLYPROTEINCAPSID PROTEIN P27 (Rous sarcomavirus) |
no annotation | 4 | ASP A 52THR A 133LEU A 129LEU A 48 | None | 1.15A | 1u18B-1em9A:0.0 | 1u18B-1em9A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i4s | RIBONUCLEASE III (Aquifexaeolicus) |
PF14622(Ribonucleas_3_3) | 4 | GLU A 110THR A 38LEU A 42LEU A 39 | None | 1.21A | 1u18B-1i4sA:undetectable | 1u18B-1i4sA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7o | 4-HYDROXYPHENYLACETATE DEGRADATIONBIFUNCTIONALISOMERASE/DECARBOXYLASE (Escherichiacoli) |
PF01557(FAA_hydrolase) | 4 | GLU A 411THR A 364LEU A 349LEU A 351 | None | 1.17A | 1u18B-1i7oA:0.0 | 1u18B-1i7oA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iaw | TYPE II RESTRICTIONENZYME NAEI (Lechevalieriaaerocolonigenes) |
PF09126(NaeI) | 4 | ASP A 123THR A 39LEU A 43LEU A 40 | None | 1.20A | 1u18B-1iawA:0.0 | 1u18B-1iawA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqo | PHOSPHOENOLPYRUVATECARBOXYLASE (Zea mays) |
PF00311(PEPcase) | 4 | GLU A 946THR A 954LEU A 955LEU A 951 | None | 1.05A | 1u18B-1jqoA:0.0 | 1u18B-1jqoA:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcw | CERULOPLASMIN (Homo sapiens) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | ASP A 576GLU A 575THR A 532LEU A 572LEU A 573 | None | 1.07A | 1u18B-1kcwA:undetectable | 1u18B-1kcwA:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ly7 | FRATAXIN (Homo sapiens) |
PF01491(Frataxin_Cyay) | 4 | GLU A 189THR A 196LEU A 198LEU A 194 | None | 0.92A | 1u18B-1ly7A:0.2 | 1u18B-1ly7A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mc2 | ACUTOHAEMONLYSIN (Deinagkistrodonacutus) |
PF00068(Phospholip_A2_1) | 4 | GLU A1108THR A1013LEU A1106LEU A1110 | None | 1.18A | 1u18B-1mc2A:0.0 | 1u18B-1mc2A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nrw | HYPOTHETICALPROTEIN, HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacillussubtilis) |
PF08282(Hydrolase_3) | 4 | ASP A 194GLU A 193LEU A 197LEU A 195 | None | 1.22A | 1u18B-1nrwA:0.0 | 1u18B-1nrwA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1og6 | HYPOTHETICALOXIDOREDUCTASE YDHF (Escherichiacoli) |
PF00248(Aldo_ket_red) | 4 | GLU A 66THR A 119LEU A 117LEU A 68 | None | 0.94A | 1u18B-1og6A:0.0 | 1u18B-1og6A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p0n | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Bacillussubtilis) |
PF01070(FMN_dh) | 4 | GLU A 298THR A 288LEU A 284LEU A 287 | None | 1.18A | 1u18B-1p0nA:undetectable | 1u18B-1p0nA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p49 | STERYL-SULFATASE (Homo sapiens) |
PF00884(Sulfatase)PF14707(Sulfatase_C) | 4 | ASP A 169GLU A 174THR A 165LEU A 167 | NoneNoneALS A 75 ( 3.8A)None | 1.14A | 1u18B-1p49A:undetectable | 1u18B-1p49A:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p7n | GAG POLYPROTEINCAPSID PROTEIN P27 (Rous sarcomavirus) |
no annotation | 4 | ASP A 52THR A 133LEU A 129LEU A 48 | None | 1.07A | 1u18B-1p7nA:undetectable | 1u18B-1p7nA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qq6 | PROTEIN(L-2-HALOACIDDEHALOGENASE) (Xanthobacterautotrophicus) |
PF00702(Hydrolase) | 4 | GLU A 76THR A 69LEU A 73LEU A 70 | None | 1.18A | 1u18B-1qq6A:undetectable | 1u18B-1qq6A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry4 | CG5884-PA (Drosophilamelanogaster) |
PF00595(PDZ) | 4 | ASP A 216THR A 209LEU A 211LEU A 212 | None | 1.06A | 1u18B-1ry4A:undetectable | 1u18B-1ry4A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1skz | ANTISTASIN (Haementeriaofficinalis) |
PF02822(Antistasin) | 4 | GLU A 104THR A 77LEU A 101LEU A 76 | None | 1.12A | 1u18B-1skzA:undetectable | 1u18B-1skzA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1snl | NUCLEOBINDIN 1 (Homo sapiens) |
PF13499(EF-hand_7) | 4 | ASP A 30GLU A 37THR A 86LEU A 84 | None | 1.18A | 1u18B-1snlA:undetectable | 1u18B-1snlA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6n | PROBABLEATP-DEPENDENT RNAHELICASE (Homo sapiens) |
PF00270(DEAD) | 4 | GLU A 55THR A 103LEU A 107LEU A 104 | None | 1.23A | 1u18B-1t6nA:undetectable | 1u18B-1t6nA:20.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u0x | NITROPHORIN 4 (Rhodniusprolixus) |
PF02087(Nitrophorin) | 5 | ASP A 30GLU A 32THR A 121LEU A 123LEU A 133 | NoneNoneHEM A 185 ( 4.3A)HEM A 185 (-4.4A)NH3 A 186 ( 4.8A) | 0.91A | 1u18B-1u0xA:31.5 | 1u18B-1u0xA:89.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbf | 231AA LONGHYPOTHETICALPROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF01135(PCMT) | 4 | GLU A 90THR A 13LEU A 68LEU A 16 | None | 0.99A | 1u18B-1vbfA:undetectable | 1u18B-1vbfA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1we1 | HEME OXYGENASE 1 (Synechocystissp. PCC 6803) |
PF01126(Heme_oxygenase) | 4 | ASP A 190GLU A 186THR A 13LEU A 9 | None | 1.16A | 1u18B-1we1A:undetectable | 1u18B-1we1A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xec | DECORIN (Bos taurus) |
PF01462(LRRNT)PF13855(LRR_8) | 4 | GLU A 103THR A 54LEU A 56LEU A 78 | None | 0.96A | 1u18B-1xecA:undetectable | 1u18B-1xecA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xoc | OLIGOPEPTIDE-BINDINGPROTEIN APPA (Bacillussubtilis) |
PF00496(SBP_bac_5) | 4 | GLU A 294THR A 484LEU A 291LEU A 486 | None | 1.16A | 1u18B-1xocA:undetectable | 1u18B-1xocA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykd | ADENYLATE CYCLASE (Anabaena sp.) |
PF01590(GAF) | 4 | ASP A 224THR A 95LEU A 98LEU A 99 | None | 1.20A | 1u18B-1ykdA:undetectable | 1u18B-1ykdA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z0a | RAS-RELATED PROTEINRAB-2A (Homo sapiens) |
PF00071(Ras) | 4 | ASP A 61THR A 27LEU A 24LEU A 23 | MG A1201 (-3.0A)NoneNoneNone | 1.19A | 1u18B-1z0aA:undetectable | 1u18B-1z0aA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a6e | RNA POLYMERASE SIGMAFACTOR RPOD (Thermusthermophilus) |
PF00140(Sigma70_r1_2)PF04539(Sigma70_r3)PF04542(Sigma70_r2)PF04545(Sigma70_r4) | 4 | GLU F 355THR F 346LEU F 349LEU F 350 | None | 1.21A | 1u18B-2a6eF:undetectable | 1u18B-2a6eF:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvm | TOXIN B (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 4 | ASP A 203THR A 140LEU A 141LEU A 137 | None | 1.12A | 1u18B-2bvmA:undetectable | 1u18B-2bvmA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cph | RNA BINDING MOTIFPROTEIN 19 (Mus musculus) |
PF00076(RRM_1) | 4 | GLU A 538THR A 528LEU A 535LEU A 524 | None | 1.12A | 1u18B-2cphA:undetectable | 1u18B-2cphA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f7v | AECTYLCITRULLINEDEACETYLASE (Xanthomonascampestris) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | GLU A 10THR A 2LEU A 4LEU A 5 | None | 0.95A | 1u18B-2f7vA:undetectable | 1u18B-2f7vA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8t | ARGONAUTE PROTEIN (Aquifexaeolicus) |
PF02171(Piwi) | 4 | GLU A 425THR A 460LEU A 461LEU A 457 | None | 1.23A | 1u18B-2f8tA:undetectable | 1u18B-2f8tA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | GLU A 467THR A 383LEU A 387LEU A 384 | None | 1.15A | 1u18B-2fgeA:undetectable | 1u18B-2fgeA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggv | NON-STRUCTURALPROTEIN 3 (West Nile virus) |
PF00949(Peptidase_S7) | 4 | GLU B 74THR B 48LEU B 49LEU B 77 | None | 1.22A | 1u18B-2ggvB:undetectable | 1u18B-2ggvB:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iae | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A56 KDA REGULATORYSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF01603(B56) | 4 | GLU B 226THR B 185LEU B 186LEU B 182 | None | 1.15A | 1u18B-2iaeB:undetectable | 1u18B-2iaeB:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inv | INSULINFRUCTOTRANSFERASE (Bacillus sp.snu-7) |
no annotation | 4 | ASP A 354THR A 391LEU A 394LEU A 356 | None | 1.21A | 1u18B-2invA:undetectable | 1u18B-2invA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jkd | PRE-MRNA LEAKAGEPROTEIN 1 (Saccharomycescerevisiae) |
PF00498(FHA) | 4 | GLU A 198THR A 165LEU A 188LEU A 186 | None | 1.00A | 1u18B-2jkdA:undetectable | 1u18B-2jkdA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2num | UBIQUINOL-CYTOCHROMEC REDUCTASEIRON-SULFUR SUBUNIT (Rhodobactersphaeroides) |
PF00355(Rieske) | 4 | ASP A 117GLU A 121LEU A 123LEU A 116 | None | 1.17A | 1u18B-2numA:undetectable | 1u18B-2numA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8w | POKEWEED ANTIVIRALPROTEIN (Phytolaccaacinosa) |
PF00161(RIP) | 4 | GLU A 205THR A 124LEU A 125LEU A 121 | None | 1.02A | 1u18B-2q8wA:undetectable | 1u18B-2q8wA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qog | PHOSPHOLIPASE A2 CB2 (Crotalusdurissus) |
PF00068(Phospholip_A2_1) | 4 | GLU A 104THR A 41LEU A 110LEU A 106 | None | 1.08A | 1u18B-2qogA:undetectable | 1u18B-2qogA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ran | ANNEXIN V (Rattusnorvegicus) |
PF00191(Annexin) | 4 | GLU A 285THR A 252LEU A 253LEU A 249 | None | 1.05A | 1u18B-2ranA:undetectable | 1u18B-2ranA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vk9 | ALPHA-TOXIN (Clostridiumnovyi) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 4 | ASP A 202THR A 142LEU A 143LEU A 139 | None | 1.14A | 1u18B-2vk9A:undetectable | 1u18B-2vk9A:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vl8 | CYTOTOXIN L (Paeniclostridiumsordellii) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 4 | ASP A 203THR A 140LEU A 141LEU A 137 | None | 1.11A | 1u18B-2vl8A:undetectable | 1u18B-2vl8A:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wnt | RIBOSOMAL PROTEIN S6KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | ASP A 596GLU A 593THR A 522LEU A 526 | None | 1.23A | 1u18B-2wntA:undetectable | 1u18B-2wntA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ze4 | PHOSPHOLIPASE D (Streptomycesantibioticus) |
PF13091(PLDc_2) | 4 | ASP A 355THR A 406LEU A 402LEU A 405 | None | 1.22A | 1u18B-2ze4A:undetectable | 1u18B-2ze4A:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4n | UNCHARACTERIZEDPROTEIN DR_0571 (Deinococcusradiodurans) |
PF01266(DAO) | 4 | GLU A 319THR A 311LEU A 313LEU A 306 | None | 1.03A | 1u18B-3c4nA:undetectable | 1u18B-3c4nA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3els | PRE-MRNA LEAKAGEPROTEIN 1 (Saccharomycescerevisiae) |
PF00498(FHA) | 4 | GLU A 198THR A 165LEU A 188LEU A 186 | None | 1.01A | 1u18B-3elsA:undetectable | 1u18B-3elsA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ez4 | 3-METHYL-2-OXOBUTANOATEHYDROXYMETHYLTRANSFERASE (Burkholderiapseudomallei) |
PF02548(Pantoate_transf) | 4 | ASP A 43GLU A 112THR A 87LEU A 83 | None | 1.23A | 1u18B-3ez4A:undetectable | 1u18B-3ez4A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmi | UPF0348 PROTEINMJ0951 (Methanocaldococcusjannaschii) |
PF05636(HIGH_NTase1)PF16581(HIGH_NTase1_ass) | 4 | GLU A 256THR A 250LEU A 254LEU A 251 | None | 1.23A | 1u18B-3gmiA:undetectable | 1u18B-3gmiA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gon | PHOSPHOMEVALONATEKINASE (Streptococcuspneumoniae) |
PF00288(GHMP_kinases_N) | 4 | GLU A 279THR A 271LEU A 273LEU A 274 | None | 0.93A | 1u18B-3gonA:undetectable | 1u18B-3gonA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3g | N-ACETYLTRANSFERASE (Trypanosomabrucei) |
PF00583(Acetyltransf_1) | 4 | ASP A 16GLU A 8THR A 52LEU A 12 | None | 1.12A | 1u18B-3i3gA:undetectable | 1u18B-3i3gA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3im9 | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Staphylococcusaureus) |
PF00698(Acyl_transf_1) | 4 | ASP A 51GLU A 53THR A 62LEU A 56 | None | 1.04A | 1u18B-3im9A:undetectable | 1u18B-3im9A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k32 | UNCHARACTERIZEDPROTEIN MJ0690 (Methanocaldococcusjannaschii) |
no annotation | 4 | ASP A 15THR A 142LEU A 146LEU A 143 | None | 1.20A | 1u18B-3k32A:undetectable | 1u18B-3k32A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nf1 | KINESIN LIGHT CHAIN1 (Homo sapiens) |
PF13374(TPR_10)PF13424(TPR_12) | 4 | GLU A 487THR A 466LEU A 470LEU A 467 | None | 1.02A | 1u18B-3nf1A:undetectable | 1u18B-3nf1A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oh8 | NUCLEOSIDE-DIPHOSPHATE SUGAR EPIMERASE(SULA FAMILY) (Corynebacteriumglutamicum) |
PF01370(Epimerase)PF08338(DUF1731) | 4 | ASP A 347GLU A 131THR A 139LEU A 136 | None | 0.91A | 1u18B-3oh8A:undetectable | 1u18B-3oh8A:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ptw | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Clostridiumperfringens) |
PF00698(Acyl_transf_1) | 4 | ASP A 51GLU A 53THR A 62LEU A 56 | None | 1.10A | 1u18B-3ptwA:undetectable | 1u18B-3ptwA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qph | TRMB, A GLOBALTRANSCRIPTIONREGULATOR (Pyrococcusfuriosus) |
PF01978(TrmB)PF11495(Regulator_TrmB) | 4 | GLU A 173THR A 154LEU A 155LEU A 151 | NoneACT A 402 (-4.4A)NoneNone | 1.20A | 1u18B-3qphA:undetectable | 1u18B-3qphA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3srz | TOXIN A (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 4 | ASP A 202THR A 139LEU A 140LEU A 136 | None | 1.14A | 1u18B-3srzA:undetectable | 1u18B-3srzA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u27 | MICROCOMPARTMENTSPROTEIN (Leptotrichiabuccalis) |
no annotation | 4 | ASP C 52GLU C 143THR C 138LEU C 135 | None | 1.14A | 1u18B-3u27C:undetectable | 1u18B-3u27C:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u44 | ATP-DEPENDENTHELICASE/DEOXYRIBONUCLEASE SUBUNIT B (Bacillussubtilis) |
PF12705(PDDEXK_1) | 4 | ASP B 185GLU B 184LEU B 87LEU B 181 | None | 0.93A | 1u18B-3u44B:undetectable | 1u18B-3u44B:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtx | MAMA (CandidatusMagnetobacteriumbavaricum) |
PF00515(TPR_1)PF13174(TPR_6)PF13181(TPR_8)PF13414(TPR_11) | 4 | ASP A 52GLU A 79THR A 87LEU A 84 | None | 1.20A | 1u18B-3vtxA:undetectable | 1u18B-3vtxA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zil | AAR187CP (Eremotheciumgossypii) |
PF16997(Wap1) | 4 | GLU A 375THR A 418LEU A 414LEU A 417 | None | 1.23A | 1u18B-3zilA:undetectable | 1u18B-3zilA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f48 | PUTATIVEUNCHARACTERIZEDPROTEIN (Xanthomonascampestris) |
PF00563(EAL) | 4 | GLU A 159THR A 213LEU A 179LEU A 181 | None | 1.22A | 1u18B-4f48A:undetectable | 1u18B-4f48A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 4 | GLU A 312THR A 323LEU A 327LEU A 324 | None | 1.22A | 1u18B-4gp1A:undetectable | 1u18B-4gp1A:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h5b | DR_1245 PROTEIN (Deinococcusradiodurans) |
PF10722(YbjN) | 4 | GLU A 113THR A 110LEU A 6LEU A 111 | None | 1.04A | 1u18B-4h5bA:undetectable | 1u18B-4h5bA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 12 (Thermusthermophilus) |
PF00361(Proton_antipo_M)PF00662(Proton_antipo_N) | 5 | ASP L 386GLU L 490THR L 392LEU L 393LEU L 389 | None | 1.23A | 1u18B-4heaL:undetectable | 1u18B-4heaL:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3f | SERINE HYDROLASECCSP0084 (Cycloclasticussp. P1) |
PF12697(Abhydrolase_6) | 4 | GLU A 214THR A 110LEU A 114LEU A 111 | None | 1.06A | 1u18B-4i3fA:undetectable | 1u18B-4i3fA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6j | WINGS APART-LIKEPROTEIN HOMOLOG (Homo sapiens) |
PF07814(WAPL) | 4 | GLU A 859THR A 941LEU A 937LEU A 940 | None | 1.01A | 1u18B-4k6jA:undetectable | 1u18B-4k6jA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmv | GLUTATHIONETRANSFERASE (Phanerochaetechrysosporium) |
PF13417(GST_N_3) | 4 | ASP A 207THR A 199LEU A 194LEU A 195 | None | 1.16A | 1u18B-4lmvA:undetectable | 1u18B-4lmvA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q1t | GLUTAMATE 5-KINASE (Burkholderiathailandensis) |
PF00696(AA_kinase)PF01472(PUA) | 4 | GLU A 48THR A 124LEU A 128LEU A 125 | None | 1.06A | 1u18B-4q1tA:undetectable | 1u18B-4q1tA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tlh | ETHANOLAMINEUTILIZATION PROTEINEUTL (Clostridiumperfringens) |
PF00936(BMC) | 4 | ASP A 52GLU A 143THR A 138LEU A 135 | None | 1.15A | 1u18B-4tlhA:undetectable | 1u18B-4tlhA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4trq | NUCLEAR MRNA EXPORTPROTEIN SAC3 (Saccharomycescerevisiae) |
PF03399(SAC3_GANP) | 4 | GLU A 280THR A 274LEU A 272LEU A 273 | None | 1.06A | 1u18B-4trqA:undetectable | 1u18B-4trqA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7l | LEUCINE-RICH REPEATSANDIMMUNOGLOBULIN-LIKEDOMAINS PROTEIN 1 (Homo sapiens) |
PF01463(LRRCT)PF13855(LRR_8) | 4 | GLU A 49THR A 30LEU A 54LEU A 26 | None | 1.14A | 1u18B-4u7lA:undetectable | 1u18B-4u7lA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upl | SULFATASE FAMILYPROTEIN (Ruegeriapomeroyi) |
PF00884(Sulfatase)PF16347(DUF4976) | 4 | GLU A 373THR A 380LEU A 377LEU A 399 | None | 1.10A | 1u18B-4uplA:undetectable | 1u18B-4uplA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9e | DEOXYGUANOSINETRIPHOSPHATETRIPHOSPHOHYDROLASE (Escherichiacoli) |
PF01966(HD) | 4 | GLU A 83THR A 340LEU A 344LEU A 341 | NoneNoneNone C H 3 ( 4.6A) | 1.16A | 1u18B-4x9eA:undetectable | 1u18B-4x9eA:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysh | GLYCINE OXIDASE (Geobacilluskaustophilus) |
PF01266(DAO) | 4 | GLU A 22THR A 358LEU A 352LEU A 348 | None | 1.18A | 1u18B-4yshA:undetectable | 1u18B-4yshA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITALPHAMETHYL-COENZYME MREDUCTASE II,SUBUNIT BETA (Methanothermobactermarburgensis) |
PF02240(MCR_gamma)PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | ASP C 252THR C 245LEU A 460LEU C 246 | None | 1.21A | 1u18B-5a8rC:undetectable | 1u18B-5a8rC:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp8 | ENT-COPALYLDIPHOSPHATE SYNTHASE (Streptomycesplatensis) |
PF00432(Prenyltrans)PF13243(SQHop_cyclase_C) | 4 | GLU A 192THR A 197LEU A 198LEU A 194 | None | 1.19A | 1u18B-5bp8A:undetectable | 1u18B-5bp8A:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci5 | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Pseudothermotogalettingae) |
PF13416(SBP_bac_8) | 4 | ASP A 82GLU A 187THR A 119LEU A 295 | T6T A 501 (-2.3A)NoneNoneNone | 1.03A | 1u18B-5ci5A:undetectable | 1u18B-5ci5A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci5 | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Pseudothermotogalettingae) |
PF13416(SBP_bac_8) | 4 | GLU A 187THR A 119LEU A 295LEU A 83 | None | 1.04A | 1u18B-5ci5A:undetectable | 1u18B-5ci5A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxl | TREHALOSE-6-PHOSPHATE PHOSPHATASE (Aspergillusfumigatus) |
PF02358(Trehalose_PPase) | 4 | GLU A 80THR A 48LEU A 52LEU A 49 | None | 0.90A | 1u18B-5dxlA:undetectable | 1u18B-5dxlA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ev7 | CONSERVED DOMAINPROTEIN (Bacillusanthracis) |
PF13402(Peptidase_M60)PF17291(M60-like_N) | 4 | GLU A 264THR A 273LEU A 269LEU A 272 | None | 1.15A | 1u18B-5ev7A:undetectable | 1u18B-5ev7A:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fdn | PHOSPHOENOLPYRUVATECARBOXYLASE 3 (Arabidopsisthaliana) |
PF00311(PEPcase) | 4 | ASP A 849GLU A 848LEU A 741LEU A 850 | None | 1.07A | 1u18B-5fdnA:undetectable | 1u18B-5fdnA:10.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fhi | GLUTATHIONES-TRANSFERASE,PUTATIVE (Aspergillusfumigatus) |
PF00043(GST_C)PF02798(GST_N) | 4 | GLU A 87THR A 78LEU A 80LEU A 81 | None | 1.20A | 1u18B-5fhiA:undetectable | 1u18B-5fhiA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gha | SULFUR CARRIER TTUBSULFUR TRANSFERASETTUA (Thermusthermophilus) |
PF01171(ATP_bind_3)no annotation | 4 | ASP E 48GLU A 13LEU E 43LEU E 44 | None | 1.01A | 1u18B-5ghaE:undetectable | 1u18B-5ghaE:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hg0 | PANTOTHENATESYNTHETASE (Francisellatularensis) |
PF02569(Pantoate_ligase) | 4 | ASP A 209THR A 218LEU A 214LEU A 217 | None | 1.22A | 1u18B-5hg0A:undetectable | 1u18B-5hg0A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Saccharomycescerevisiae) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | GLU B 691THR B 599LEU B 603LEU B 600 | None | 1.05A | 1u18B-5ip9B:undetectable | 1u18B-5ip9B:9.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ixq | RECEPTOR-LIKEPROTEIN KINASE 5 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13855(LRR_8) | 4 | GLU A 310THR A 284LEU A 306LEU A 307 | None | 1.22A | 1u18B-5ixqA:undetectable | 1u18B-5ixqA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jqn | ALIPHATIC AMIDASE (Nesterenkoniasp. AN1) |
PF00795(CN_hydrolase) | 4 | ASP A 147GLU A 41LEU A 142LEU A 143 | None | 1.19A | 1u18B-5jqnA:undetectable | 1u18B-5jqnA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lac | 3CL PROTEASE (Alphamesonivirus1) |
PF17222(Peptidase_C107) | 4 | GLU A 236THR A 242LEU A 238LEU A 241 | None | 1.22A | 1u18B-5lacA:undetectable | 1u18B-5lacA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5muf | SERINE/THREONINE-PROTEIN PHOSPHATASEPGAM5, MITOCHONDRIAL (Homo sapiens) |
PF00300(His_Phos_1) | 4 | GLU A 129THR A 121LEU A 123LEU A 120 | None | 1.22A | 1u18B-5mufA:undetectable | 1u18B-5mufA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanotorrisformicicus) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | GLU A 389THR A 380LEU A 384LEU A 381 | None | 1.15A | 1u18B-5n28A:undetectable | 1u18B-5n28A:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol2 | ELECTRON TRANSFERFLAVOPROTEIN SMALLSUBUNIT (Clostridioidesdifficile) |
no annotation | 4 | GLU B 206THR B 65LEU B 89LEU B 88 | None | 1.09A | 1u18B-5ol2B:undetectable | 1u18B-5ol2B:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1s | SEPARIN (Saccharomycescerevisiae) |
PF03568(Peptidase_C50) | 4 | GLU A 407THR A 356LEU A 360LEU A 357 | None | 0.79A | 1u18B-5u1sA:undetectable | 1u18B-5u1sA:8.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0x | TIP41-LIKE PROTEIN (Mus musculus) |
no annotation | 4 | GLU A 152THR A 199LEU A 181LEU A 183 | None | 1.08A | 1u18B-5w0xA:undetectable | 1u18B-5w0xA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wtk | CRISPR-ASSOCIATEDENDORIBONUCLEASEC2C2 (Leptotrichiashahii) |
no annotation | 4 | ASP A1301GLU A1298LEU A1379LEU A1342 | None | 1.15A | 1u18B-5wtkA:undetectable | 1u18B-5wtkA:8.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | RNA POLYMERASE IISUBUNIT B32 (Komagataellaphaffii) |
PF03874(RNA_pol_Rpb4) | 4 | ASP D 86THR D 105LEU D 109LEU D 106 | None | 1.00A | 1u18B-5xogD:undetectable | 1u18B-5xogD:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S8 (Trichomonasvaginalis) |
PF01201(Ribosomal_S8e) | 4 | GLU I 40THR I 36LEU I 58LEU I 60 | NoneNone C 21483 ( 4.3A)None | 1.10A | 1u18B-5xyiI:undetectable | 1u18B-5xyiI:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6co7 | PREDICTED PROTEIN (Nematostellavectensis) |
no annotation | 4 | GLU A 660THR A 665LEU A 666LEU A 662 | None | 1.23A | 1u18B-6co7A:undetectable | 1u18B-6co7A:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6emk | SERINE/THREONINE-PROTEIN KINASE TOR2 (Saccharomycescerevisiae) |
no annotation | 4 | ASP A2237GLU A2234THR A2319LEU A2322 | None | 1.05A | 1u18B-6emkA:undetectable | 1u18B-6emkA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exn | PRE-MRNA-SPLICINGFACTOR CWC2 (Saccharomycescerevisiae) |
no annotation | 4 | ASP M 209THR M 203LEU M 204LEU M 205 | None | 1.20A | 1u18B-6exnM:undetectable | 1u18B-6exnM:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fuz | KINESIN LIGHT CHAIN1,KINESIN LIGHTCHAIN1,C-JUN-AMINO-TERMINALKINASE-INTERACTINGPROTEIN 1 (Homo sapiens;Mus musculus) |
no annotation | 4 | GLU A 487THR A 466LEU A 470LEU A 467 | None | 0.85A | 1u18B-6fuzA:undetectable | 1u18B-6fuzA:18.28 |