SIMILAR PATTERNS OF AMINO ACIDS FOR 1U18_B_HSMB402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em9 GAG POLYPROTEIN
CAPSID PROTEIN P27


(Rous sarcoma
virus)
no annotation 4 ASP A  52
THR A 133
LEU A 129
LEU A  48
None
1.15A 1u18B-1em9A:
0.0
1u18B-1em9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4s RIBONUCLEASE III

(Aquifex
aeolicus)
PF14622
(Ribonucleas_3_3)
4 GLU A 110
THR A  38
LEU A  42
LEU A  39
None
1.21A 1u18B-1i4sA:
undetectable
1u18B-1i4sA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
4 GLU A 411
THR A 364
LEU A 349
LEU A 351
None
1.17A 1u18B-1i7oA:
0.0
1u18B-1i7oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI


(Lechevalieria
aerocolonigenes)
PF09126
(NaeI)
4 ASP A 123
THR A  39
LEU A  43
LEU A  40
None
1.20A 1u18B-1iawA:
0.0
1u18B-1iawA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Zea mays)
PF00311
(PEPcase)
4 GLU A 946
THR A 954
LEU A 955
LEU A 951
None
1.05A 1u18B-1jqoA:
0.0
1u18B-1jqoA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 ASP A 576
GLU A 575
THR A 532
LEU A 572
LEU A 573
None
1.07A 1u18B-1kcwA:
undetectable
1u18B-1kcwA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ly7 FRATAXIN

(Homo sapiens)
PF01491
(Frataxin_Cyay)
4 GLU A 189
THR A 196
LEU A 198
LEU A 194
None
0.92A 1u18B-1ly7A:
0.2
1u18B-1ly7A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus)
PF00068
(Phospholip_A2_1)
4 GLU A1108
THR A1013
LEU A1106
LEU A1110
None
1.18A 1u18B-1mc2A:
0.0
1u18B-1mc2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacillus
subtilis)
PF08282
(Hydrolase_3)
4 ASP A 194
GLU A 193
LEU A 197
LEU A 195
None
1.22A 1u18B-1nrwA:
0.0
1u18B-1nrwA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF


(Escherichia
coli)
PF00248
(Aldo_ket_red)
4 GLU A  66
THR A 119
LEU A 117
LEU A  68
None
0.94A 1u18B-1og6A:
0.0
1u18B-1og6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Bacillus
subtilis)
PF01070
(FMN_dh)
4 GLU A 298
THR A 288
LEU A 284
LEU A 287
None
1.18A 1u18B-1p0nA:
undetectable
1u18B-1p0nA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
4 ASP A 169
GLU A 174
THR A 165
LEU A 167
None
None
ALS  A  75 ( 3.8A)
None
1.14A 1u18B-1p49A:
undetectable
1u18B-1p49A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27


(Rous sarcoma
virus)
no annotation 4 ASP A  52
THR A 133
LEU A 129
LEU A  48
None
1.07A 1u18B-1p7nA:
undetectable
1u18B-1p7nA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq6 PROTEIN
(L-2-HALOACID
DEHALOGENASE)


(Xanthobacter
autotrophicus)
PF00702
(Hydrolase)
4 GLU A  76
THR A  69
LEU A  73
LEU A  70
None
1.18A 1u18B-1qq6A:
undetectable
1u18B-1qq6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry4 CG5884-PA

(Drosophila
melanogaster)
PF00595
(PDZ)
4 ASP A 216
THR A 209
LEU A 211
LEU A 212
None
1.06A 1u18B-1ry4A:
undetectable
1u18B-1ry4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skz ANTISTASIN

(Haementeria
officinalis)
PF02822
(Antistasin)
4 GLU A 104
THR A  77
LEU A 101
LEU A  76
None
1.12A 1u18B-1skzA:
undetectable
1u18B-1skzA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snl NUCLEOBINDIN 1

(Homo sapiens)
PF13499
(EF-hand_7)
4 ASP A  30
GLU A  37
THR A  86
LEU A  84
None
1.18A 1u18B-1snlA:
undetectable
1u18B-1snlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE


(Homo sapiens)
PF00270
(DEAD)
4 GLU A  55
THR A 103
LEU A 107
LEU A 104
None
1.23A 1u18B-1t6nA:
undetectable
1u18B-1t6nA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u0x NITROPHORIN 4

(Rhodnius
prolixus)
PF02087
(Nitrophorin)
5 ASP A  30
GLU A  32
THR A 121
LEU A 123
LEU A 133
None
None
HEM  A 185 ( 4.3A)
HEM  A 185 (-4.4A)
NH3  A 186 ( 4.8A)
0.91A 1u18B-1u0xA:
31.5
1u18B-1u0xA:
89.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF01135
(PCMT)
4 GLU A  90
THR A  13
LEU A  68
LEU A  16
None
0.99A 1u18B-1vbfA:
undetectable
1u18B-1vbfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we1 HEME OXYGENASE 1

(Synechocystis
sp. PCC 6803)
PF01126
(Heme_oxygenase)
4 ASP A 190
GLU A 186
THR A  13
LEU A   9
None
1.16A 1u18B-1we1A:
undetectable
1u18B-1we1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus)
PF01462
(LRRNT)
PF13855
(LRR_8)
4 GLU A 103
THR A  54
LEU A  56
LEU A  78
None
0.96A 1u18B-1xecA:
undetectable
1u18B-1xecA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA


(Bacillus
subtilis)
PF00496
(SBP_bac_5)
4 GLU A 294
THR A 484
LEU A 291
LEU A 486
None
1.16A 1u18B-1xocA:
undetectable
1u18B-1xocA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.)
PF01590
(GAF)
4 ASP A 224
THR A  95
LEU A  98
LEU A  99
None
1.20A 1u18B-1ykdA:
undetectable
1u18B-1ykdA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0a RAS-RELATED PROTEIN
RAB-2A


(Homo sapiens)
PF00071
(Ras)
4 ASP A  61
THR A  27
LEU A  24
LEU A  23
MG  A1201 (-3.0A)
None
None
None
1.19A 1u18B-1z0aA:
undetectable
1u18B-1z0aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD


(Thermus
thermophilus)
PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
4 GLU F 355
THR F 346
LEU F 349
LEU F 350
None
1.21A 1u18B-2a6eF:
undetectable
1u18B-2a6eF:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
4 ASP A 203
THR A 140
LEU A 141
LEU A 137
None
1.12A 1u18B-2bvmA:
undetectable
1u18B-2bvmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cph RNA BINDING MOTIF
PROTEIN 19


(Mus musculus)
PF00076
(RRM_1)
4 GLU A 538
THR A 528
LEU A 535
LEU A 524
None
1.12A 1u18B-2cphA:
undetectable
1u18B-2cphA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE


(Xanthomonas
campestris)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 GLU A  10
THR A   2
LEU A   4
LEU A   5
None
0.95A 1u18B-2f7vA:
undetectable
1u18B-2f7vA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus)
PF02171
(Piwi)
4 GLU A 425
THR A 460
LEU A 461
LEU A 457
None
1.23A 1u18B-2f8tA:
undetectable
1u18B-2f8tA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)


(Arabidopsis
thaliana)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
4 GLU A 467
THR A 383
LEU A 387
LEU A 384
None
1.15A 1u18B-2fgeA:
undetectable
1u18B-2fgeA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggv NON-STRUCTURAL
PROTEIN 3


(West Nile virus)
PF00949
(Peptidase_S7)
4 GLU B  74
THR B  48
LEU B  49
LEU B  77
None
1.22A 1u18B-2ggvB:
undetectable
1u18B-2ggvB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM


(Homo sapiens)
PF01603
(B56)
4 GLU B 226
THR B 185
LEU B 186
LEU B 182
None
1.15A 1u18B-2iaeB:
undetectable
1u18B-2iaeB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE


(Bacillus sp.
snu-7)
no annotation 4 ASP A 354
THR A 391
LEU A 394
LEU A 356
None
1.21A 1u18B-2invA:
undetectable
1u18B-2invA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkd PRE-MRNA LEAKAGE
PROTEIN 1


(Saccharomyces
cerevisiae)
PF00498
(FHA)
4 GLU A 198
THR A 165
LEU A 188
LEU A 186
None
1.00A 1u18B-2jkdA:
undetectable
1u18B-2jkdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2num UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT


(Rhodobacter
sphaeroides)
PF00355
(Rieske)
4 ASP A 117
GLU A 121
LEU A 123
LEU A 116
None
1.17A 1u18B-2numA:
undetectable
1u18B-2numA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
4 GLU A 205
THR A 124
LEU A 125
LEU A 121
None
1.02A 1u18B-2q8wA:
undetectable
1u18B-2q8wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qog PHOSPHOLIPASE A2 CB2

(Crotalus
durissus)
PF00068
(Phospholip_A2_1)
4 GLU A 104
THR A  41
LEU A 110
LEU A 106
None
1.08A 1u18B-2qogA:
undetectable
1u18B-2qogA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ran ANNEXIN V

(Rattus
norvegicus)
PF00191
(Annexin)
4 GLU A 285
THR A 252
LEU A 253
LEU A 249
None
1.05A 1u18B-2ranA:
undetectable
1u18B-2ranA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
4 ASP A 202
THR A 142
LEU A 143
LEU A 139
None
1.14A 1u18B-2vk9A:
undetectable
1u18B-2vk9A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
4 ASP A 203
THR A 140
LEU A 141
LEU A 137
None
1.11A 1u18B-2vl8A:
undetectable
1u18B-2vl8A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 ASP A 596
GLU A 593
THR A 522
LEU A 526
None
1.23A 1u18B-2wntA:
undetectable
1u18B-2wntA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus)
PF13091
(PLDc_2)
4 ASP A 355
THR A 406
LEU A 402
LEU A 405
None
1.22A 1u18B-2ze4A:
undetectable
1u18B-2ze4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571


(Deinococcus
radiodurans)
PF01266
(DAO)
4 GLU A 319
THR A 311
LEU A 313
LEU A 306
None
1.03A 1u18B-3c4nA:
undetectable
1u18B-3c4nA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3els PRE-MRNA LEAKAGE
PROTEIN 1


(Saccharomyces
cerevisiae)
PF00498
(FHA)
4 GLU A 198
THR A 165
LEU A 188
LEU A 186
None
1.01A 1u18B-3elsA:
undetectable
1u18B-3elsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE


(Burkholderia
pseudomallei)
PF02548
(Pantoate_transf)
4 ASP A  43
GLU A 112
THR A  87
LEU A  83
None
1.23A 1u18B-3ez4A:
undetectable
1u18B-3ez4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951


(Methanocaldococcus
jannaschii)
PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass)
4 GLU A 256
THR A 250
LEU A 254
LEU A 251
None
1.23A 1u18B-3gmiA:
undetectable
1u18B-3gmiA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE


(Streptococcus
pneumoniae)
PF00288
(GHMP_kinases_N)
4 GLU A 279
THR A 271
LEU A 273
LEU A 274
None
0.93A 1u18B-3gonA:
undetectable
1u18B-3gonA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3g N-ACETYLTRANSFERASE

(Trypanosoma
brucei)
PF00583
(Acetyltransf_1)
4 ASP A  16
GLU A   8
THR A  52
LEU A  12
None
1.12A 1u18B-3i3gA:
undetectable
1u18B-3i3gA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Staphylococcus
aureus)
PF00698
(Acyl_transf_1)
4 ASP A  51
GLU A  53
THR A  62
LEU A  56
None
1.04A 1u18B-3im9A:
undetectable
1u18B-3im9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k32 UNCHARACTERIZED
PROTEIN MJ0690


(Methanocaldococcus
jannaschii)
no annotation 4 ASP A  15
THR A 142
LEU A 146
LEU A 143
None
1.20A 1u18B-3k32A:
undetectable
1u18B-3k32A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf1 KINESIN LIGHT CHAIN
1


(Homo sapiens)
PF13374
(TPR_10)
PF13424
(TPR_12)
4 GLU A 487
THR A 466
LEU A 470
LEU A 467
None
1.02A 1u18B-3nf1A:
undetectable
1u18B-3nf1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)


(Corynebacterium
glutamicum)
PF01370
(Epimerase)
PF08338
(DUF1731)
4 ASP A 347
GLU A 131
THR A 139
LEU A 136
None
0.91A 1u18B-3oh8A:
undetectable
1u18B-3oh8A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Clostridium
perfringens)
PF00698
(Acyl_transf_1)
4 ASP A  51
GLU A  53
THR A  62
LEU A  56
None
1.10A 1u18B-3ptwA:
undetectable
1u18B-3ptwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR


(Pyrococcus
furiosus)
PF01978
(TrmB)
PF11495
(Regulator_TrmB)
4 GLU A 173
THR A 154
LEU A 155
LEU A 151
None
ACT  A 402 (-4.4A)
None
None
1.20A 1u18B-3qphA:
undetectable
1u18B-3qphA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
4 ASP A 202
THR A 139
LEU A 140
LEU A 136
None
1.14A 1u18B-3srzA:
undetectable
1u18B-3srzA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u27 MICROCOMPARTMENTS
PROTEIN


(Leptotrichia
buccalis)
no annotation 4 ASP C  52
GLU C 143
THR C 138
LEU C 135
None
1.14A 1u18B-3u27C:
undetectable
1u18B-3u27C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B


(Bacillus
subtilis)
PF12705
(PDDEXK_1)
4 ASP B 185
GLU B 184
LEU B  87
LEU B 181
None
0.93A 1u18B-3u44B:
undetectable
1u18B-3u44B:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtx MAMA

(Candidatus
Magnetobacterium
bavaricum)
PF00515
(TPR_1)
PF13174
(TPR_6)
PF13181
(TPR_8)
PF13414
(TPR_11)
4 ASP A  52
GLU A  79
THR A  87
LEU A  84
None
1.20A 1u18B-3vtxA:
undetectable
1u18B-3vtxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii)
PF16997
(Wap1)
4 GLU A 375
THR A 418
LEU A 414
LEU A 417
None
1.23A 1u18B-3zilA:
undetectable
1u18B-3zilA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Xanthomonas
campestris)
PF00563
(EAL)
4 GLU A 159
THR A 213
LEU A 179
LEU A 181
None
1.22A 1u18B-4f48A:
undetectable
1u18B-4f48A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
4 GLU A 312
THR A 323
LEU A 327
LEU A 324
None
1.22A 1u18B-4gp1A:
undetectable
1u18B-4gp1A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5b DR_1245 PROTEIN

(Deinococcus
radiodurans)
PF10722
(YbjN)
4 GLU A 113
THR A 110
LEU A   6
LEU A 111
None
1.04A 1u18B-4h5bA:
undetectable
1u18B-4h5bA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
5 ASP L 386
GLU L 490
THR L 392
LEU L 393
LEU L 389
None
1.23A 1u18B-4heaL:
undetectable
1u18B-4heaL:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084


(Cycloclasticus
sp. P1)
PF12697
(Abhydrolase_6)
4 GLU A 214
THR A 110
LEU A 114
LEU A 111
None
1.06A 1u18B-4i3fA:
undetectable
1u18B-4i3fA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG


(Homo sapiens)
PF07814
(WAPL)
4 GLU A 859
THR A 941
LEU A 937
LEU A 940
None
1.01A 1u18B-4k6jA:
undetectable
1u18B-4k6jA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE


(Phanerochaete
chrysosporium)
PF13417
(GST_N_3)
4 ASP A 207
THR A 199
LEU A 194
LEU A 195
None
1.16A 1u18B-4lmvA:
undetectable
1u18B-4lmvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1t GLUTAMATE 5-KINASE

(Burkholderia
thailandensis)
PF00696
(AA_kinase)
PF01472
(PUA)
4 GLU A  48
THR A 124
LEU A 128
LEU A 125
None
1.06A 1u18B-4q1tA:
undetectable
1u18B-4q1tA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL


(Clostridium
perfringens)
PF00936
(BMC)
4 ASP A  52
GLU A 143
THR A 138
LEU A 135
None
1.15A 1u18B-4tlhA:
undetectable
1u18B-4tlhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3


(Saccharomyces
cerevisiae)
PF03399
(SAC3_GANP)
4 GLU A 280
THR A 274
LEU A 272
LEU A 273
None
1.06A 1u18B-4trqA:
undetectable
1u18B-4trqA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1


(Homo sapiens)
PF01463
(LRRCT)
PF13855
(LRR_8)
4 GLU A  49
THR A  30
LEU A  54
LEU A  26
None
1.14A 1u18B-4u7lA:
undetectable
1u18B-4u7lA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN


(Ruegeria
pomeroyi)
PF00884
(Sulfatase)
PF16347
(DUF4976)
4 GLU A 373
THR A 380
LEU A 377
LEU A 399
None
1.10A 1u18B-4uplA:
undetectable
1u18B-4uplA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE


(Escherichia
coli)
PF01966
(HD)
4 GLU A  83
THR A 340
LEU A 344
LEU A 341
None
None
None
C  H   3 ( 4.6A)
1.16A 1u18B-4x9eA:
undetectable
1u18B-4x9eA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus)
PF01266
(DAO)
4 GLU A  22
THR A 358
LEU A 352
LEU A 348
None
1.18A 1u18B-4yshA:
undetectable
1u18B-4yshA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA


(Methanothermobacter
marburgensis)
PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 ASP C 252
THR C 245
LEU A 460
LEU C 246
None
1.21A 1u18B-5a8rC:
undetectable
1u18B-5a8rC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE


(Streptomyces
platensis)
PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C)
4 GLU A 192
THR A 197
LEU A 198
LEU A 194
None
1.19A 1u18B-5bp8A:
undetectable
1u18B-5bp8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Pseudothermotoga
lettingae)
PF13416
(SBP_bac_8)
4 ASP A  82
GLU A 187
THR A 119
LEU A 295
T6T  A 501 (-2.3A)
None
None
None
1.03A 1u18B-5ci5A:
undetectable
1u18B-5ci5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Pseudothermotoga
lettingae)
PF13416
(SBP_bac_8)
4 GLU A 187
THR A 119
LEU A 295
LEU A  83
None
1.04A 1u18B-5ci5A:
undetectable
1u18B-5ci5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE


(Aspergillus
fumigatus)
PF02358
(Trehalose_PPase)
4 GLU A  80
THR A  48
LEU A  52
LEU A  49
None
0.90A 1u18B-5dxlA:
undetectable
1u18B-5dxlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN


(Bacillus
anthracis)
PF13402
(Peptidase_M60)
PF17291
(M60-like_N)
4 GLU A 264
THR A 273
LEU A 269
LEU A 272
None
1.15A 1u18B-5ev7A:
undetectable
1u18B-5ev7A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3


(Arabidopsis
thaliana)
PF00311
(PEPcase)
4 ASP A 849
GLU A 848
LEU A 741
LEU A 850
None
1.07A 1u18B-5fdnA:
undetectable
1u18B-5fdnA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhi GLUTATHIONE
S-TRANSFERASE,
PUTATIVE


(Aspergillus
fumigatus)
PF00043
(GST_C)
PF02798
(GST_N)
4 GLU A  87
THR A  78
LEU A  80
LEU A  81
None
1.20A 1u18B-5fhiA:
undetectable
1u18B-5fhiA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gha SULFUR CARRIER TTUB
SULFUR TRANSFERASE
TTUA


(Thermus
thermophilus)
PF01171
(ATP_bind_3)
no annotation
4 ASP E  48
GLU A  13
LEU E  43
LEU E  44
None
1.01A 1u18B-5ghaE:
undetectable
1u18B-5ghaE:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hg0 PANTOTHENATE
SYNTHETASE


(Francisella
tularensis)
PF02569
(Pantoate_ligase)
4 ASP A 209
THR A 218
LEU A 214
LEU A 217
None
1.22A 1u18B-5hg0A:
undetectable
1u18B-5hg0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Saccharomyces
cerevisiae)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 GLU B 691
THR B 599
LEU B 603
LEU B 600
None
1.05A 1u18B-5ip9B:
undetectable
1u18B-5ip9B:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5


(Arabidopsis
thaliana)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 GLU A 310
THR A 284
LEU A 306
LEU A 307
None
1.22A 1u18B-5ixqA:
undetectable
1u18B-5ixqA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1)
PF00795
(CN_hydrolase)
4 ASP A 147
GLU A  41
LEU A 142
LEU A 143
None
1.19A 1u18B-5jqnA:
undetectable
1u18B-5jqnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lac 3CL PROTEASE

(Alphamesonivirus
1)
PF17222
(Peptidase_C107)
4 GLU A 236
THR A 242
LEU A 238
LEU A 241
None
1.22A 1u18B-5lacA:
undetectable
1u18B-5lacA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL


(Homo sapiens)
PF00300
(His_Phos_1)
4 GLU A 129
THR A 121
LEU A 123
LEU A 120
None
1.22A 1u18B-5mufA:
undetectable
1u18B-5mufA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA


(Methanotorris
formicicus)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 GLU A 389
THR A 380
LEU A 384
LEU A 381
None
1.15A 1u18B-5n28A:
undetectable
1u18B-5n28A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT


(Clostridioides
difficile)
no annotation 4 GLU B 206
THR B  65
LEU B  89
LEU B  88
None
1.09A 1u18B-5ol2B:
undetectable
1u18B-5ol2B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae)
PF03568
(Peptidase_C50)
4 GLU A 407
THR A 356
LEU A 360
LEU A 357
None
0.79A 1u18B-5u1sA:
undetectable
1u18B-5u1sA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus)
no annotation 4 GLU A 152
THR A 199
LEU A 181
LEU A 183
None
1.08A 1u18B-5w0xA:
undetectable
1u18B-5w0xA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2


(Leptotrichia
shahii)
no annotation 4 ASP A1301
GLU A1298
LEU A1379
LEU A1342
None
1.15A 1u18B-5wtkA:
undetectable
1u18B-5wtkA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
SUBUNIT B32


(Komagataella
phaffii)
PF03874
(RNA_pol_Rpb4)
4 ASP D  86
THR D 105
LEU D 109
LEU D 106
None
1.00A 1u18B-5xogD:
undetectable
1u18B-5xogD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S8


(Trichomonas
vaginalis)
PF01201
(Ribosomal_S8e)
4 GLU I  40
THR I  36
LEU I  58
LEU I  60
None
None
C  21483 ( 4.3A)
None
1.10A 1u18B-5xyiI:
undetectable
1u18B-5xyiI:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis)
no annotation 4 GLU A 660
THR A 665
LEU A 666
LEU A 662
None
1.23A 1u18B-6co7A:
undetectable
1u18B-6co7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2


(Saccharomyces
cerevisiae)
no annotation 4 ASP A2237
GLU A2234
THR A2319
LEU A2322
None
1.05A 1u18B-6emkA:
undetectable
1u18B-6emkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exn PRE-MRNA-SPLICING
FACTOR CWC2


(Saccharomyces
cerevisiae)
no annotation 4 ASP M 209
THR M 203
LEU M 204
LEU M 205
None
1.20A 1u18B-6exnM:
undetectable
1u18B-6exnM:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuz KINESIN LIGHT CHAIN
1,KINESIN LIGHT
CHAIN
1,C-JUN-AMINO-TERMIN
AL
KINASE-INTERACTING
PROTEIN 1


(Homo sapiens;
Mus musculus)
no annotation 4 GLU A 487
THR A 466
LEU A 470
LEU A 467
None
0.85A 1u18B-6fuzA:
undetectable
1u18B-6fuzA:
18.28