SIMILAR PATTERNS OF AMINO ACIDS FOR 1U18_A_HSMA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ASP A  84
LEU A  79
LEU A  82
LEU A  80
 None
 1.40A 1u18A-1b0aA:
undetectable		 1u18A-1b0aA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1doq RNA POLYMERASE ALPHA
SUBUNIT

(Thermus
thermophilus) 		PF03118
(RNA_pol_A_CTD) 		4 ASP A 287
LEU A 281
LEU A 313
LEU A 283
 None
 1.33A 1u18A-1doqA:
undetectable		 1u18A-1doqA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyv TOLL-LIKE RECEPTOR 1

(Homo sapiens) 		PF01582
(TIR) 		4 ASP A 647
LEU A 730
LEU A 697
LEU A 731
 None
 1.23A 1u18A-1fyvA:
0.0		 1u18A-1fyvA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i81 PUTATIVE SNRNP
SM-LIKE PROTEIN

(Methanothermobacter
thermautotrophicus) 		PF01423
(LSM) 		4 ASP A  44
LEU A  15
LEU A  18
LEU A  45
 None
 1.35A 1u18A-1i81A:
undetectable		 1u18A-1i81A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 ASP A 161
LEU A   7
LEU A  75
LEU A   6
 None
 1.34A 1u18A-1jroA:
0.0		 1u18A-1jroA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ASP A 438
LEU A 445
LEU A 321
LEU A 441
 NAD  A 900 (-2.8A)
None
NAD  A 900 (-4.3A)
None
 1.27A 1u18A-1la2A:
0.0		 1u18A-1la2A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		4 ASP A 257
LEU A 252
LEU A 255
LEU A 253
 None
 1.39A 1u18A-1n0wA:
0.0		 1u18A-1n0wA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o77 TOLL-LIKE RECEPTOR 2

(Homo sapiens) 		PF01582
(TIR) 		4 ASP A 651
LEU A 736
LEU A 703
LEU A 737
 None
 1.23A 1u18A-1o77A:
0.0		 1u18A-1o77A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ors POTASSIUM CHANNEL

(Aeropyrum
pernix) 		no annotation 4 ASP C  62
LEU C  69
LEU C  97
LEU C  65
 None
 1.31A 1u18A-1orsC:
undetectable		 1u18A-1orsC:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcw CT610

(Chlamydia
trachomatis) 		PF03070
(TENA_THI-4) 		4 ASP A 196
LEU A 192
LEU A 131
LEU A 193
 None
 1.19A 1u18A-1rcwA:
undetectable		 1u18A-1rcwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 ASP C 824
LEU C 840
LEU C 837
LEU C 839
 None
 1.40A 1u18A-1u6gC:
0.0		 1u18A-1u6gC:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		4 ASP A 345
LEU A  10
LEU A   4
LEU A   8
 None
 1.34A 1u18A-1umfA:
0.0		 1u18A-1umfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermus
thermophilus) 		PF03009
(GDPD) 		4 ASP A  37
LEU A 211
LEU A 219
LEU A   9
 None
 1.31A 1u18A-1vd6A:
undetectable		 1u18A-1vd6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 ASP A  61
LEU A 193
LEU A 183
LEU A 161
 None
 1.42A 1u18A-2a14A:
undetectable		 1u18A-2a14A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.20A 1u18A-2btjA:
undetectable		 1u18A-2btjA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 ASP A 705
LEU A 714
LEU A 698
LEU A 710
 None
 1.42A 1u18A-2c4mA:
undetectable		 1u18A-2c4mA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.23A 1u18A-2gw3A:
undetectable		 1u18A-2gw3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		4 ASP A  55
LEU B 162
LEU B 137
LEU B 161
 None
 1.24A 1u18A-2gw4A:
undetectable		 1u18A-2gw4A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		4 ASP A 231
LEU A 226
LEU A 229
LEU A 119
 None
 1.34A 1u18A-2j0aA:
undetectable		 1u18A-2j0aA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j67 TOLL LIKE RECEPTOR
10

(Homo sapiens) 		PF01582
(TIR) 		4 ASP A 644
LEU A 729
LEU A 696
LEU A 730
 None
 1.28A 1u18A-2j67A:
undetectable		 1u18A-2j67A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyh VOLTAGE-GATED
POTASSIUM CHANNEL

(Aeropyrum
pernix) 		no annotation 4 ASP A  62
LEU A  69
LEU A  97
LEU A  65
 None
 1.27A 1u18A-2kyhA:
undetectable		 1u18A-2kyhA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ly7 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Bacillus
subtilis) 		PF00562
(RNA_pol_Rpb2_6) 		4 ASP A  58
LEU A  42
LEU A  39
LEU A  60
 None
 1.42A 1u18A-2ly7A:
undetectable		 1u18A-2ly7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF13676
(TIR_2) 		4 ASP A  89
LEU A 139
LEU A 180
LEU A 138
 None
 1.29A 1u18A-2m1wA:
undetectable		 1u18A-2m1wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr7 SECRETION ACTIVATOR
PROTEIN, PUTATIVE

(Porphyromonas
gingivalis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		4 ASP A  61
LEU A  56
LEU A  59
LEU A  12
 None
 1.34A 1u18A-2nr7A:
undetectable		 1u18A-2nr7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484

(Clavularia sp.) 		PF01353
(GFP) 		4 ASP A  59
LEU A 166
LEU A 141
LEU A 165
 None
 1.24A 1u18A-2otbA:
undetectable		 1u18A-2otbA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4d LYSINE
DECARBOXYLASE-LIKE
PROTEIN AT5G11950

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		4 ASP A 155
LEU A 150
LEU A 153
LEU A 151
 None
 1.40A 1u18A-2q4dA:
undetectable		 1u18A-2q4dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		4 ASP A 219
LEU A 214
LEU A 217
LEU A 215
 None
 1.39A 1u18A-2vefA:
undetectable		 1u18A-2vefA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		4 ASP A 183
LEU A 129
LEU A 122
LEU A 127
 None
 1.12A 1u18A-2vrtA:
undetectable		 1u18A-2vrtA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzx GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.21A 1u18A-2vzxA:
undetectable		 1u18A-2vzxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg6 PUTATIVE
UNCHARACTERIZED
PROTEIN ST2620

(Sulfurisphaera
tokodaii) 		PF13419
(HAD_2) 		4 ASP A  99
LEU A 104
LEU A 101
LEU A 207
 None
 1.42A 1u18A-2zg6A:
undetectable		 1u18A-2zg6A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ASP B 127
LEU B 176
LEU B 153
LEU B 175
 None
 1.42A 1u18A-3a79B:
undetectable		 1u18A-3a79B:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.19A 1u18A-3adfA:
undetectable		 1u18A-3adfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		4 ASP A 111
LEU A  91
LEU A  88
LEU A  90
 None
 1.24A 1u18A-3am6A:
undetectable		 1u18A-3am6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b33 SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		PF00989
(PAS) 		4 ASP A  75
LEU A  63
LEU A  60
LEU A  62
 None
 1.38A 1u18A-3b33A:
undetectable		 1u18A-3b33A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibx PUTATIVE THIAMINASE
II

(Helicobacter
pylori) 		PF03070
(TENA_THI-4) 		4 ASP A  44
LEU A  49
LEU A  46
LEU A  48
 None
 1.36A 1u18A-3ibxA:
undetectable		 1u18A-3ibxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 ASP A  25
LEU A  20
LEU A  23
LEU A  21
 None
 1.31A 1u18A-3j4jA:
undetectable		 1u18A-3j4jA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 ASP A 162
LEU A 136
LEU A 211
LEU A 209
 None
 1.23A 1u18A-3m33A:
undetectable		 1u18A-3m33A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ASP D 134
LEU D 125
LEU D 126
LEU D 420
 None
 1.27A 1u18A-3oaaD:
undetectable		 1u18A-3oaaD:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p39 NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 ASP A 168
LEU A 158
LEU A 161
LEU A 110
 None
 1.35A 1u18A-3p39A:
undetectable		 1u18A-3p39A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkx UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HI_0893

(Haemophilus
influenzae) 		PF00440
(TetR_N) 		4 ASP A 145
LEU A 150
LEU A 147
LEU A 149
 None
 1.38A 1u18A-3qkxA:
undetectable		 1u18A-3qkxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Anaerococcus
prevotii) 		PF00215
(OMPdecase) 		4 ASP A 120
LEU A  90
LEU A  85
LEU A  91
 None
 1.28A 1u18A-3r89A:
undetectable		 1u18A-3r89A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 358
LEU A 329
LEU A 364
LEU A 325
 None
 1.38A 1u18A-3vwaA:
undetectable		 1u18A-3vwaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhn PA_0080

(Pseudomonas
aeruginosa) 		PF12790
(T6SS-SciN) 		4 ASP A  43
LEU A  93
LEU A 111
LEU A  40
 None
 1.36A 1u18A-3zhnA:
undetectable		 1u18A-3zhnA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 ASP A 342
LEU A 354
LEU A 352
LEU A 341
 None
 1.34A 1u18A-3zpcA:
undetectable		 1u18A-3zpcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ASP A  84
LEU A  79
LEU A  82
LEU A  80
 None
 1.29A 1u18A-4a5oA:
undetectable		 1u18A-4a5oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab5 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		4 ASP A 202
LEU A 207
LEU A 212
LEU A 205
 None
 1.12A 1u18A-4ab5A:
undetectable		 1u18A-4ab5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxo LEA X(6) GFP-LIKE
PROTEINS

(synthetic
construct) 		PF01353
(GFP) 		4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.18A 1u18A-4dxoA:
undetectable		 1u18A-4dxoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		4 ASP A 112
LEU A 225
LEU A 220
LEU A 222
 None
 1.40A 1u18A-4f3eA:
undetectable		 1u18A-4f3eA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbz DELTARHODOPSIN

(Haloterrigena
thermotolerans) 		PF01036
(Bac_rhodopsin) 		4 ASP A 114
LEU A  94
LEU A  91
LEU A  93
 None
None
L2P  A 304 ( 4.9A)
None
 1.28A 1u18A-4fbzA:
undetectable		 1u18A-4fbzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 ASP A 147
LEU A 294
LEU A 295
LEU A 293
 None
 1.25A 1u18A-4fdhA:
undetectable		 1u18A-4fdhA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc2 ASFP504

(Alcyonium) 		PF01353
(GFP) 		4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.23A 1u18A-4jc2A:
undetectable		 1u18A-4jc2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5c LOOP DESIGNED
ANKYRIN REPEAT
PROTEIN NRAN1_G06_C

(Escherichia
coli) 		PF12796
(Ank_2) 		4 ASP A  13
LEU A  18
LEU A  19
LEU A  14
 None
 1.37A 1u18A-4k5cA:
undetectable		 1u18A-4k5cA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		4 ASP A  94
LEU A  85
LEU A 111
LEU A  86
 None
 1.34A 1u18A-4l4xA:
undetectable		 1u18A-4l4xA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lda TADZ

(Pseudomonas
aeruginosa) 		PF16968
(TadZ_N) 		4 ASP A  44
LEU A  39
LEU A  42
LEU A  40
 None
 1.37A 1u18A-4ldaA:
undetectable		 1u18A-4ldaA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ASP A 114
LEU A  77
LEU A  78
LEU A  75
 None
 0.99A 1u18A-4nndA:
undetectable		 1u18A-4nndA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 ASP A 152
LEU A 172
LEU A 154
LEU A 149
 None
 1.38A 1u18A-4oalA:
undetectable		 1u18A-4oalA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om7 TOLL-LIKE RECEPTOR 6

(Homo sapiens) 		PF01582
(TIR) 		4 ASP A 652
LEU A 735
LEU A 702
LEU A 736
 None
 1.23A 1u18A-4om7A:
undetectable		 1u18A-4om7A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 ASP A 295
LEU A 169
LEU A 377
LEU A 168
 None
 1.24A 1u18A-4oy4A:
undetectable		 1u18A-4oy4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A

(Mus musculus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ASP A 238
LEU A 259
LEU A 298
LEU A 258
 None
 1.16A 1u18A-4pirA:
undetectable		 1u18A-4pirA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmu ENDO-1,4-BETA-XYLANA
SE A

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 ASP A 266
LEU A 295
LEU A 270
LEU A 268
 None
 1.17A 1u18A-4pmuA:
undetectable		 1u18A-4pmuA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tza FLUORESCENT PROTEIN

(synthetic
construct) 		no annotation 4 ASP C  55
LEU C 162
LEU C 137
LEU C 161
 None
 1.19A 1u18A-4tzaC:
undetectable		 1u18A-4tzaC:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 ASP A 292
LEU A 287
LEU A 290
LEU A 288
 None
 1.41A 1u18A-4u4eA:
undetectable		 1u18A-4u4eA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 ASP A 679
LEU A 674
LEU A 677
LEU A 675
 None
 1.38A 1u18A-4um2A:
undetectable		 1u18A-4um2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN UL29M,
MRPL47

(Sus scrofa) 		PF06984
(MRP-L47) 		4 ASP 2 153
LEU 2 158
LEU 2 155
LEU 2 157
 None
 1.41A 1u18A-4v192:
undetectable		 1u18A-4v192:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		4 ASP A  60
LEU A  55
LEU A  58
LEU A  56
 None
 1.26A 1u18A-4wvaA:
undetectable		 1u18A-4wvaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 ASP A 607
LEU A 663
LEU A 618
LEU A 610
 None
 1.09A 1u18A-4xwhA:
undetectable		 1u18A-4xwhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 ASP B 596
LEU B 618
LEU B 621
LEU B 599
 None
 1.12A 1u18A-4yg8B:
undetectable		 1u18A-4yg8B:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ASP A 423
LEU A 541
LEU A 540
LEU A 256
 None
 1.40A 1u18A-4yzwA:
undetectable		 1u18A-4yzwA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ASP A  13
LEU A  18
LEU A  19
LEU A  14
 None
 1.34A 1u18A-4zfhA:
undetectable		 1u18A-4zfhA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq0 14-3-3 PROTEIN

(Giardia
intestinalis) 		PF00244
(14-3-3) 		4 ASP A 104
LEU A 109
LEU A 106
LEU A 108
 None
 1.41A 1u18A-4zq0A:
undetectable		 1u18A-4zq0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ax0 RHODOPSIN I

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		4 ASP A 119
LEU A  99
LEU A  96
LEU A  98
 None
OLB  A 304 ( 4.4A)
OLB  A 304 (-4.6A)
None
 1.29A 1u18A-5ax0A:
undetectable		 1u18A-5ax0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 4 ASP A 175
LEU A 124
LEU A 129
LEU A 121
 None
 1.38A 1u18A-5bykA:
undetectable		 1u18A-5bykA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfn STIMULATOR OF
INTERFERON GENES

(Nematostella
vectensis) 		PF15009
(TMEM173) 		4 ASP A 310
LEU A 305
LEU A 308
LEU A 306
 None
 1.40A 1u18A-5cfnA:
undetectable		 1u18A-5cfnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		4 ASP A  90
LEU A  27
LEU A  25
LEU A  89
 None
 1.39A 1u18A-5dihA:
undetectable		 1u18A-5dihA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exc GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		4 ASP A  55
LEU I 162
LEU I 137
LEU I 161
 None
 1.20A 1u18A-5excA:
undetectable		 1u18A-5excA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		4 ASP A 436
LEU A 440
LEU A 530
LEU A 439
 None
 1.42A 1u18A-5gggA:
undetectable		 1u18A-5gggA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 ASP A 257
LEU A 252
LEU A 255
LEU A 253
 None
 1.38A 1u18A-5h1cA:
undetectable		 1u18A-5h1cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 ASP A 235
LEU A  74
LEU A 282
LEU A  73
 None
 1.36A 1u18A-5i3aA:
undetectable		 1u18A-5i3aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itz DESIGNED ANKYRIN
REPEAT PROTEIN
(DARPIN) D1

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ASP F  13
LEU F  18
LEU F  19
LEU F  14
 None
 1.37A 1u18A-5itzF:
undetectable		 1u18A-5itzF:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbm CHROMATIN ASSEMBLY
FACTOR 1 SUBUNIT P90

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 535
LEU A 530
LEU A 533
LEU A 531
 None
 1.29A 1u18A-5jbmA:
undetectable		 1u18A-5jbmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA

(Homo sapiens;
synthetic
construct) 		no annotation 4 ASP B 975
LEU B 954
LEU B 951
LEU B 953
 None
 1.22A 1u18A-5jcpB:
undetectable		 1u18A-5jcpB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		4 ASP A 179
LEU A 238
LEU A 177
LEU A 183
 None
 1.17A 1u18A-5kh0A:
undetectable		 1u18A-5kh0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1

(Chaetomium
thermophilum) 		PF03164
(Mon1) 		4 ASP A 296
LEU A 303
LEU A 279
LEU A 299
 None
 1.22A 1u18A-5lddA:
undetectable		 1u18A-5lddA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le0 PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Homo sapiens) 		PF12130
(DUF3585) 		4 ASP B 979
LEU B 974
LEU B 977
LEU B 975
 None
 1.30A 1u18A-5le0B:
undetectable		 1u18A-5le0B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		4 ASP C 622
LEU C 627
LEU C 628
LEU C 623
 None
 1.34A 1u18A-5mioC:
undetectable		 1u18A-5mioC:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o34 ENOYL-COA HYDRATASE
CARB HOMOLOGUE

(Streptomyces
cattleya) 		no annotation 4 ASP A 217
LEU A 220
LEU A 215
LEU A 219
 None
 1.27A 1u18A-5o34A:
undetectable		 1u18A-5o34A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 ASP T  16
LEU T  55
LEU T  59
LEU T  54
 None
 1.31A 1u18A-5ojsT:
undetectable		 1u18A-5ojsT:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 4 ASP A 366
LEU A 421
LEU A 417
LEU A 368
 None
 1.39A 1u18A-5oltA:
undetectable		 1u18A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 ASP A 636
LEU A 628
LEU A 632
LEU A 629
 None
 0.97A 1u18A-5oqrA:
undetectable		 1u18A-5oqrA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 4 ASP A 184
LEU A 133
LEU A 138
LEU A 130
 None
 1.31A 1u18A-5tiwA:
undetectable		 1u18A-5tiwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 ASP C 197
LEU C 202
LEU C 199
LEU C 201
 None
 1.39A 1u18A-5uj7C:
undetectable		 1u18A-5uj7C:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 ASP A 370
LEU A 365
LEU A 368
LEU A 366
 None
 1.34A 1u18A-5uohA:
undetectable		 1u18A-5uohA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk1 MAJOR CAPSID PROTEIN

(Pseudoalteromonas
phage TW1) 		no annotation 4 ASP A 231
LEU A 226
LEU A 229
LEU A 227
 None
 1.30A 1u18A-5wk1A:
undetectable		 1u18A-5wk1A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 4 ASP A 221
LEU A 248
LEU A 245
LEU A 247
 None
 1.26A 1u18A-5yu1A:
undetectable		 1u18A-5yu1A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 ASP A 552
LEU A 504
LEU A 506
LEU A 550
 None
 1.05A 1u18A-5yudA:
undetectable		 1u18A-5yudA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 ASP A  21
LEU A  16
LEU A  19
LEU A  17
 None
 1.32A 1u18A-6a8mA:
undetectable		 1u18A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c80 CYTOKININ OXIDASE
LUCKX1.1

(Linum
usitatissimum) 		no annotation 4 ASP A 150
LEU A 170
LEU A 152
LEU A 147
 None
 1.35A 1u18A-6c80A:
undetectable		 1u18A-6c80A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL3

(Homo sapiens) 		no annotation 4 ASP M 266
LEU M 261
LEU M 264
LEU M 262
 None
 1.16A 1u18A-6cetM:
undetectable		 1u18A-6cetM:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezy -

(-) 		no annotation 4 ASP A 165
LEU A  99
LEU A 163
LEU A 156
 ASP  A 165 ( 0.5A)
LEU  A  99 ( 0.5A)
LEU  A 163 ( 0.6A)
LEU  A 156 ( 0.6A)
 1.36A 1u18A-6ezyA:
undetectable		 1u18A-6ezyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fri ALKANAL
MONOOXYGENASE BETA
CHAIN

(Photobacterium
leiognathi) 		no annotation 4 ASP A  32
LEU A  64
LEU A  67
LEU A  71
 None
 1.32A 1u18A-6friA:
undetectable		 1u18A-6friA:
18.23