SIMILAR PATTERNS OF AMINO ACIDS FOR 1TZ8_D_DESD128_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		4 LYS A 232
LEU A 291
LEU A 225
SER A 224
 None
 1.48A 1tz8D-1lt8A:
0.0		 1tz8D-1lt8A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		4 LYS A 241
LEU A 237
LEU A 213
SER A 212
 None
 1.42A 1tz8D-1p9pA:
0.0		 1tz8D-1p9pA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 None
 0.55A 1tz8D-1tfpA:
19.7		 1tz8D-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqr 3-DEHYDROQUINATE
DEHYDRATASE

(Actinobacillus
pleuropneumoniae) 		PF01220
(DHquinase_II) 		4 LYS A  17
LEU A  15
LEU A  28
SER A  29
 None
 1.45A 1tz8D-1uqrA:
0.0		 1tz8D-1uqrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.47A 1tz8D-2csdA:
undetectable		 1tz8D-2csdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LYS A 136
LEU A 132
LEU A 179
SER A 180
 None
 1.40A 1tz8D-2e6kA:
0.0		 1tz8D-2e6kA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe9 PROTEIN VTS1

(Saccharomyces
cerevisiae) 		PF07647
(SAM_2) 		4 LYS A  30
LEU A  28
LEU A  26
SER A  25
 None
 1.46A 1tz8D-2fe9A:
undetectable		 1tz8D-2fe9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5g PUTATIVE LIPOPROTEIN

(Campylobacter
jejuni) 		PF04187
(Cofac_haem_bdg) 		4 LYS X 189
LEU X 186
LEU X 178
SER X 173
 None
HEM  X 605 (-4.3A)
HEM  X 605 ( 4.9A)
None
 1.47A 1tz8D-2g5gX:
undetectable		 1tz8D-2g5gX:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		4 LYS A 452
LEU A 507
LEU A 397
SER A 398
 None
 1.35A 1tz8D-2khoA:
0.2		 1tz8D-2khoA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzf UNCHARACTERIZED
PROTEIN YKZF

(Bacillus
subtilis) 		PF14156
(AbbA_antirepres) 		4 LYS A  56
LEU A   8
LEU A  34
SER A  37
 None
 1.29A 1tz8D-2lzfA:
undetectable		 1tz8D-2lzfA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhe UNCHARACTERIZED
PROTEIN

(Caulobacter
vibrioides) 		PF13773
(DUF4170) 		4 LYS A   4
LEU A   6
LEU A   7
SER A  37
 None
 1.21A 1tz8D-2mheA:
undetectable		 1tz8D-2mheA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxz PYRSV_GP04

(Pyrobaculum
spherical virus) 		no annotation 4 LYS A  25
LEU A  20
LEU A  67
SER A  68
 None
 1.50A 1tz8D-2vxzA:
undetectable		 1tz8D-2vxzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		4 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 1.34A 1tz8D-3bwsA:
3.9		 1tz8D-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		4 LYS A  96
LEU A  98
LEU A 125
SER A 126
 None
 1.24A 1tz8D-3bydA:
undetectable		 1tz8D-3bydA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LYS A 231
LEU A 228
LEU A 248
SER A 251
 None
 1.42A 1tz8D-3eh7A:
undetectable		 1tz8D-3eh7A:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.97A 1tz8D-3fc8A:
23.8		 1tz8D-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju0 PHAGE INTEGRASE

(Pectobacterium
atrosepticum) 		PF13356
(Arm-DNA-bind_3) 		4 LYS A  72
LEU A  40
LEU A  51
SER A  82
 None
 1.33A 1tz8D-3ju0A:
undetectable		 1tz8D-3ju0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 LYS A  25
LEU A 254
LEU A  62
SER A  65
 None
 1.44A 1tz8D-3m7dA:
undetectable		 1tz8D-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.40A 1tz8D-3m7dA:
undetectable		 1tz8D-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1

(Saccharomyces
cerevisiae) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 LYS A 229
LEU A 176
LEU A 291
SER A 233
 None
 1.50A 1tz8D-3opwA:
undetectable		 1tz8D-3opwA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 LYS A 192
LEU A 258
LEU A 227
SER A 226
 None
 1.48A 1tz8D-3ozxA:
undetectable		 1tz8D-3ozxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LYS A  28
LEU A  30
LEU A  34
SER A  35
 None
 1.45A 1tz8D-3rzeA:
undetectable		 1tz8D-3rzeA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 LYS A  96
LEU A 100
LEU A  35
SER A  34
 NAP  A 291 (-3.1A)
None
None
None
 1.35A 1tz8D-3uxjA:
undetectable		 1tz8D-3uxjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		4 LYS B  12
LEU B   9
LEU D 124
SER D 123
 None
 1.48A 1tz8D-3wcuB:
undetectable		 1tz8D-3wcuB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 LYS A 613
LEU A 617
LEU A 619
SER A 620
 None
 1.35A 1tz8D-4c51A:
undetectable		 1tz8D-4c51A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 1.08A 1tz8D-4conA:
undetectable		 1tz8D-4conA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.46A 1tz8D-4gfjA:
undetectable		 1tz8D-4gfjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		4 LYS A 436
LEU A 430
LEU A 494
SER A 495
 None
 1.48A 1tz8D-4gkpA:
undetectable		 1tz8D-4gkpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22

(Schizosaccharomyces
pombe) 		PF06179
(Med22)
PF10156
(Med17) 		4 LYS Q 212
LEU V  82
LEU Q 227
SER Q 228
 None
 1.33A 1tz8D-4h63Q:
undetectable		 1tz8D-4h63Q:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 LYS M   1
LEU M   4
LEU M   8
SER M  32
 None
 1.41A 1tz8D-4heaM:
undetectable		 1tz8D-4heaM:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 LYS C  65
LEU C  62
LEU C  82
SER C  85
 None
 1.20A 1tz8D-4nv1C:
undetectable		 1tz8D-4nv1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LYS A 294
LEU A 290
LEU A 289
SER A 169
 None
 1.12A 1tz8D-4onoA:
undetectable		 1tz8D-4onoA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 LYS A 548
LEU A 550
LEU A 544
SER A 496
 None
 1.37A 1tz8D-4pf1A:
2.5		 1tz8D-4pf1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qd2 HEMAGGLUTININ
COMPONENT HA70

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 LYS A 419
LEU A 504
LEU A 507
SER A 510
 None
 1.44A 1tz8D-4qd2A:
undetectable		 1tz8D-4qd2A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqr 3,5-EPIMERASE/4-REDU
CTASE

(Arabidopsis
thaliana) 		PF04321
(RmlD_sub_bind) 		4 LYS A  30
LEU A  27
LEU A 204
SER A 207
 None
 1.29A 1tz8D-4qqrA:
undetectable		 1tz8D-4qqrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzu ASPARTIC PROTEASE
INHIBITOR 11

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		4 LYS A 128
LEU A  80
LEU A  71
SER A  72
 None
 1.46A 1tz8D-5dzuA:
undetectable		 1tz8D-5dzuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.41A 1tz8D-5hm5A:
undetectable		 1tz8D-5hm5A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 LYS A 620
LEU A 624
LEU A 626
SER A 627
 None
 1.29A 1tz8D-5kqiA:
undetectable		 1tz8D-5kqiA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LYS A1775
LEU A1778
LEU A1825
SER A1824
 None
 1.38A 1tz8D-5nugA:
undetectable		 1tz8D-5nugA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.28A 1tz8D-5vbbA:
undetectable		 1tz8D-5vbbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		no annotation 4 LYS A  75
LEU A  77
LEU A 126
SER A 118
 None
 1.43A 1tz8D-6c8aA:
1.1		 1tz8D-6c8aA:
23.81