SIMILAR PATTERNS OF AMINO ACIDS FOR 1TZ8_C_DESC129

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		4 LEU A 465
ALA A 451
LEU A 449
SER A 443
 None
 0.80A 1tz8C-1b2hA:
undetectable
1tz8D-1b2hA:
undetectable		 1tz8C-1b2hA:
13.15
1tz8D-1b2hA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis virus) 		no annotation 4 LYS C 198
LEU C 205
LEU C 196
SER C 193
 None
 0.95A 1tz8C-1b35C:
undetectable
1tz8D-1b35C:
undetectable		 1tz8C-1b35C:
14.74
1tz8D-1b35C:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 ALA A 137
LEU A 135
SER A 130
SER A 131
 None
 0.95A 1tz8C-1budA:
undetectable
1tz8D-1budA:
0.0		 1tz8C-1budA:
19.07
1tz8D-1budA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7y STEM/LEAF LECTIN
DB58

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		4 LEU A 165
ALA A  68
SER A 228
SER A   7
 None
 0.55A 1tz8C-1g7yA:
0.5
1tz8D-1g7yA:
0.1		 1tz8C-1g7yA:
21.79
1tz8D-1g7yA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.27A 1tz8C-1gkeA:
22.0
1tz8D-1gkeA:
22.0		 1tz8C-1gkeA:
83.33
1tz8D-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4

(Rattus
norvegicus) 		PF00106
(adh_short) 		4 LEU A 172
ALA A 150
LEU A 169
SER A 165
 None
 0.95A 1tz8C-1gz6A:
undetectable
1tz8D-1gz6A:
undetectable		 1tz8C-1gz6A:
17.93
1tz8D-1gz6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 LEU A 326
ALA A 299
SER A 317
SER A 319
 None
 0.98A 1tz8C-1hjuA:
undetectable
1tz8D-1hjuA:
0.0		 1tz8C-1hjuA:
21.40
1tz8D-1hjuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 LEU A1081
ALA A1098
LEU A1083
SER A1085
 None
 1.06A 1tz8C-1jl5A:
undetectable
1tz8D-1jl5A:
undetectable		 1tz8C-1jl5A:
12.64
1tz8D-1jl5A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 ALA A 164
LEU A 160
SER A 159
SER A  70
 None
 0.91A 1tz8C-1k72A:
undetectable
1tz8D-1k72A:
0.0		 1tz8C-1k72A:
12.89
1tz8D-1k72A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrv LEUCINE-RICH REPEAT
VARIANT

(Azotobacter
vinelandii) 		PF01816
(LRV)
PF05484
(LRV_FeS) 		4 LEU A  79
ALA A  93
LEU A  82
SER A  86
 None
 0.96A 1tz8C-1lrvA:
undetectable
1tz8D-1lrvA:
undetectable		 1tz8C-1lrvA:
18.70
1tz8D-1lrvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu2 LECTIN

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		4 LEU A 165
ALA A  68
SER A 228
SER A   7
 None
 0.53A 1tz8C-1lu2A:
undetectable
1tz8D-1lu2A:
undetectable		 1tz8C-1lu2A:
20.95
1tz8D-1lu2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 LEU A2906
ALA A2948
LEU A2946
SER A2933
 None
 0.95A 1tz8C-1miuA:
undetectable
1tz8D-1miuA:
undetectable		 1tz8C-1miuA:
10.68
1tz8D-1miuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0u PROTEIN YWIB

(Bacillus
subtilis) 		PF09148
(DUF1934) 		4 LEU A 129
ALA A 117
SER A  99
SER A  82
 None
 0.66A 1tz8C-1r0uA:
undetectable
1tz8D-1r0uA:
undetectable		 1tz8C-1r0uA:
23.53
1tz8D-1r0uA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.86A 1tz8C-1sb3B:
undetectable
1tz8D-1sb3B:
undetectable		 1tz8C-1sb3B:
16.72
1tz8D-1sb3B:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.57A 1tz8C-1sn2A:
20.5
1tz8D-1sn2A:
20.9		 1tz8C-1sn2A:
54.62
1tz8D-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 LEU A 181
ALA A 178
LEU A 176
SER A 171
 None
 0.94A 1tz8C-1su7A:
undetectable
1tz8D-1su7A:
undetectable		 1tz8C-1su7A:
11.95
1tz8D-1su7A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 393
ALA B 389
LEU B 395
SER B 396
 None
 1.00A 1tz8C-1t3qB:
undetectable
1tz8D-1t3qB:
undetectable		 1tz8C-1t3qB:
10.89
1tz8D-1t3qB:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te4 CONSERVED PROTEIN
MTH187

(Methanothermobacter
thermautotrophicus) 		PF13646
(HEAT_2) 		4 LEU A  58
ALA A  74
LEU A  61
SER A  66
 None
 0.97A 1tz8C-1te4A:
undetectable
1tz8D-1te4A:
undetectable		 1tz8C-1te4A:
20.42
1tz8D-1te4A:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.47A 1tz8C-1tfpA:
19.6
1tz8D-1tfpA:
19.7		 1tz8C-1tfpA:
73.85
1tz8D-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 None
 0.86A 1tz8C-1tfpA:
19.6
1tz8D-1tfpA:
19.7		 1tz8C-1tfpA:
73.85
1tz8D-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhc PUTATIVE KHG/KDPG
ALDOLASE

(Haemophilus
influenzae) 		PF01081
(Aldolase) 		4 LEU A  59
ALA A  62
SER A  86
SER A  85
 None
 1.02A 1tz8C-1vhcA:
undetectable
1tz8D-1vhcA:
undetectable		 1tz8C-1vhcA:
22.62
1tz8D-1vhcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 380
ALA A 219
LEU A 221
SER A 341
 None
 0.81A 1tz8C-1wuuA:
undetectable
1tz8D-1wuuA:
undetectable		 1tz8C-1wuuA:
17.66
1tz8D-1wuuA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		4 LEU A  81
LEU A  86
SER A  10
SER A  12
 None
 0.96A 1tz8C-1y51A:
undetectable
1tz8D-1y51A:
undetectable		 1tz8C-1y51A:
25.00
1tz8D-1y51A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus) 		PF00191
(Annexin) 		4 LEU A 157
ALA A 159
LEU A 114
SER A 116
 None
 1.04A 1tz8C-1yiiA:
undetectable
1tz8D-1yiiA:
undetectable		 1tz8C-1yiiA:
17.14
1tz8D-1yiiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.67A 1tz8C-1yr2A:
undetectable
1tz8D-1yr2A:
undetectable		 1tz8C-1yr2A:
11.34
1tz8D-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19

(synthetic
construct) 		PF12796
(Ank_2) 		4 LEU A  84
ALA A 108
SER A  81
SER A  79
 None
 0.99A 1tz8C-2bkgA:
undetectable
1tz8D-2bkgA:
undetectable		 1tz8C-2bkgA:
20.48
1tz8D-2bkgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 LYS A 244
ALA A 248
LEU A 225
SER A 253
 None
 0.92A 1tz8C-2cycA:
undetectable
1tz8D-2cycA:
undetectable		 1tz8C-2cycA:
15.80
1tz8D-2cycA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 1.04A 1tz8C-2eyqA:
undetectable
1tz8D-2eyqA:
undetectable		 1tz8C-2eyqA:
8.05
1tz8D-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jre C60-1 PDZ DOMAIN
PEPTIDE

(-) 		PF00595
(PDZ) 		4 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.88A 1tz8C-2jreA:
undetectable
1tz8D-2jreA:
undetectable		 1tz8C-2jreA:
22.31
1tz8D-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		5 LEU A  78
ALA A  16
LEU A 103
SER A 111
SER A  11
 None
 1.41A 1tz8C-2k7hA:
undetectable
1tz8D-2k7hA:
undetectable		 1tz8C-2k7hA:
26.43
1tz8D-2k7hA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le9 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Homo sapiens) 		PF13895
(Ig_2) 		4 LYS A  43
LEU A  48
LEU A  50
SER A  53
 None
 0.89A 1tz8C-2le9A:
1.1
1tz8D-2le9A:
undetectable		 1tz8C-2le9A:
18.46
1tz8D-2le9A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 LEU A 208
ALA A  57
LEU A 142
SER A 141
 None
 1.03A 1tz8C-2nlzA:
undetectable
1tz8D-2nlzA:
undetectable		 1tz8C-2nlzA:
15.28
1tz8D-2nlzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF00481
(PP2C) 		4 LYS A 192
LEU A 190
LEU A 285
SER A  27
 None
 0.87A 1tz8C-2popA:
undetectable
1tz8D-2popA:
undetectable		 1tz8C-2popA:
17.56
1tz8D-2popA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 LEU A 199
ALA A 175
LEU A 177
SER A 151
 None
None
None
NAD  A 400 (-3.8A)
 0.94A 1tz8C-2pv7A:
undetectable
1tz8D-2pv7A:
undetectable		 1tz8C-2pv7A:
19.37
1tz8D-2pv7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 324
ALA A 309
SER A 268
SER A 258
 None
 0.84A 1tz8C-2yd0A:
undetectable
1tz8D-2yd0A:
undetectable		 1tz8C-2yd0A:
10.09
1tz8D-2yd0A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 LEU A 190
ALA A 203
LEU A 205
SER A 149
 None
 0.88A 1tz8C-2zi8A:
undetectable
1tz8D-2zi8A:
undetectable		 1tz8C-2zi8A:
17.94
1tz8D-2zi8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.98A 1tz8C-3aqpA:
undetectable
1tz8D-3aqpA:
undetectable		 1tz8C-3aqpA:
9.85
1tz8D-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		4 ALA A  93
LEU A  91
SER A  88
SER A  85
 None
None
None
PLP  A 500 (-3.5A)
 1.00A 1tz8C-3bb8A:
undetectable
1tz8D-3bb8A:
undetectable		 1tz8C-3bb8A:
15.40
1tz8D-3bb8A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.99A 1tz8C-3bdwB:
undetectable
1tz8D-3bdwB:
undetectable		 1tz8C-3bdwB:
21.43
1tz8D-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ALA A 299
LEU A 297
SER A 294
SER A 291
 None
 1.05A 1tz8C-3be5A:
undetectable
1tz8D-3be5A:
undetectable		 1tz8C-3be5A:
18.18
1tz8D-3be5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 LEU B 434
ALA B 426
LEU B 424
SER B 237
 None
 0.61A 1tz8C-3bg0B:
undetectable
1tz8D-3bg0B:
undetectable		 1tz8C-3bg0B:
15.30
1tz8D-3bg0B:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS A  46
ALA A  44
LEU A  40
SER A  41
 None
 0.85A 1tz8C-3bjlA:
3.7
1tz8D-3bjlA:
undetectable		 1tz8C-3bjlA:
22.79
1tz8D-3bjlA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		4 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 0.98A 1tz8C-3bwsA:
undetectable
1tz8D-3bwsA:
3.9		 1tz8C-3bwsA:
16.97
1tz8D-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C 237
LEU C 258
SER C 208
SER C 198
 None
 0.78A 1tz8C-3degC:
undetectable
1tz8D-3degC:
undetectable		 1tz8C-3degC:
13.74
1tz8D-3degC:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		4 LYS A 146
LEU A 142
ALA A 118
LEU A 122
 None
 0.94A 1tz8C-3dpiA:
undetectable
1tz8D-3dpiA:
undetectable		 1tz8C-3dpiA:
20.59
1tz8D-3dpiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 LYS 1 214
ALA 1 213
LEU 1 229
SER 1 231
 None
 0.89A 1tz8C-3epd1:
undetectable
1tz8D-3epd1:
undetectable		 1tz8C-3epd1:
21.51
1tz8D-3epd1:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.69A 1tz8C-3fc8A:
23.3
1tz8D-3fc8A:
23.8		 1tz8C-3fc8A:
100.00
1tz8D-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		PF12704
(MacB_PCD) 		4 LEU A 461
ALA A 377
LEU A 379
SER A 363
 None
 0.83A 1tz8C-3ftjA:
undetectable
1tz8D-3ftjA:
undetectable		 1tz8C-3ftjA:
18.61
1tz8D-3ftjA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9g SONEPCIZUMAB
ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 124
ALA H 137
SER H 127
SER H 128
 None
 1.05A 1tz8C-3i9gH:
undetectable
1tz8D-3i9gH:
undetectable		 1tz8C-3i9gH:
21.36
1tz8D-3i9gH:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 371
ALA A 276
LEU A 357
SER A 358
 None
 1.06A 1tz8C-3m9vA:
undetectable
1tz8D-3m9vA:
undetectable		 1tz8C-3m9vA:
14.82
1tz8D-3m9vA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 ALA A 653
LEU A 651
SER A 648
SER A 645
 None
 1.05A 1tz8C-3nowA:
undetectable
1tz8D-3nowA:
undetectable		 1tz8C-3nowA:
9.31
1tz8D-3nowA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzh 5F6 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 128
ALA H 141
SER H 131
SER H 132
 None
 1.00A 1tz8C-3nzhH:
3.7
1tz8D-3nzhH:
undetectable		 1tz8C-3nzhH:
21.40
1tz8D-3nzhH:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on3 KETO/OXOACID
FERREDOXIN
OXIDOREDUCTASE,
GAMMA SUBUNIT

(Geobacter
sulfurreducens) 		PF01558
(POR) 		4 LEU A  95
ALA A  72
LEU A  74
SER A  53
 None
 0.90A 1tz8C-3on3A:
undetectable
1tz8D-3on3A:
undetectable		 1tz8C-3on3A:
22.83
1tz8D-3on3A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		4 LEU A 102
ALA A 118
LEU A 120
SER A  40
 None
 0.93A 1tz8C-3p7nA:
undetectable
1tz8D-3p7nA:
undetectable		 1tz8C-3p7nA:
18.04
1tz8D-3p7nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H

(Bacillus
subtilis) 		PF13176
(TPR_7) 		4 LYS A 316
LEU A 320
ALA A 306
SER A 339
 None
 1.03A 1tz8C-3q15A:
undetectable
1tz8D-3q15A:
undetectable		 1tz8C-3q15A:
15.68
1tz8D-3q15A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 119
ALA A  89
LEU A  91
SER A  64
 None
 0.99A 1tz8C-3q41A:
undetectable
1tz8D-3q41A:
undetectable		 1tz8C-3q41A:
16.71
1tz8D-3q41A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 HEAVY
CHAIN

(Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 130
ALA H 143
SER H 133
SER H 134
 None
None
None
SO4  H 232 (-2.6A)
 0.99A 1tz8C-3qpxH:
3.6
1tz8D-3qpxH:
3.3		 1tz8C-3qpxH:
19.00
1tz8D-3qpxH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 LEU A 212
ALA A 236
SER A 264
SER A 265
 None
 1.03A 1tz8C-3t2nA:
undetectable
1tz8D-3t2nA:
undetectable		 1tz8C-3t2nA:
18.06
1tz8D-3t2nA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u62 SHIKIMATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 190
ALA A 210
LEU A 193
SER A 194
 None
 0.96A 1tz8C-3u62A:
undetectable
1tz8D-3u62A:
undetectable		 1tz8C-3u62A:
23.38
1tz8D-3u62A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcs ERYTHROAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		4 LEU A 187
ALA A  90
SER A 250
SER A  28
 EDO  A1007 ( 4.4A)
None
None
None
 0.57A 1tz8C-3wcsA:
undetectable
1tz8D-3wcsA:
undetectable		 1tz8C-3wcsA:
18.75
1tz8D-3wcsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo4 INTERLEUKIN-18
RECEPTOR 1
INTERLEUKIN-18
RECEPTOR ACCESSORY
PROTEIN

(Homo sapiens) 		PF00047
(ig)
PF13895
(Ig_2)
no annotation 		4 LEU C 254
LEU B 218
SER B 238
SER B 279
 None
None
NAG  B 909 ( 3.4A)
NAG  B 909 ( 3.7A)
 1.02A 1tz8C-3wo4C:
3.0
1tz8D-3wo4C:
undetectable		 1tz8C-3wo4C:
15.70
1tz8D-3wo4C:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ypi TRIOSEPHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF00121
(TIM) 		4 LEU A 204
ALA A 200
LEU A 192
SER A 194
 None
 1.02A 1tz8C-3ypiA:
undetectable
1tz8D-3ypiA:
undetectable		 1tz8C-3ypiA:
17.39
1tz8D-3ypiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 LEU A 134
LEU A 165
SER A 229
SER A 347
 None
 0.97A 1tz8C-4b46A:
undetectable
1tz8D-4b46A:
undetectable		 1tz8C-4b46A:
16.58
1tz8D-4b46A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU A 124
ALA A 178
SER A 169
SER A 170
 None
 1.01A 1tz8C-4bplA:
undetectable
1tz8D-4bplA:
undetectable		 1tz8C-4bplA:
12.92
1tz8D-4bplA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 LYS A 613
LEU A 617
LEU A 619
SER A 620
 None
 0.95A 1tz8C-4c51A:
undetectable
1tz8D-4c51A:
undetectable		 1tz8C-4c51A:
11.11
1tz8D-4c51A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 0.90A 1tz8C-4conA:
undetectable
1tz8D-4conA:
undetectable		 1tz8C-4conA:
11.55
1tz8D-4conA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH

(Cupriavidus
metallidurans) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		4 LEU A 163
ALA A 159
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 0.97A 1tz8C-4cxfA:
undetectable
1tz8D-4cxfA:
undetectable		 1tz8C-4cxfA:
20.10
1tz8D-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		4 ALA A 314
LEU A 312
SER A 309
SER A 306
 None
 1.02A 1tz8C-4d7qA:
undetectable
1tz8D-4d7qA:
undetectable		 1tz8C-4d7qA:
15.99
1tz8D-4d7qA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		4 LEU A  44
LEU A  41
SER A  38
SER A  68
 None
 0.96A 1tz8C-4exlA:
undetectable
1tz8D-4exlA:
undetectable		 1tz8C-4exlA:
19.18
1tz8D-4exlA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 249
LEU A 192
SER A 194
SER A 195
 None
 0.90A 1tz8C-4ez5A:
undetectable
1tz8D-4ez5A:
undetectable		 1tz8C-4ez5A:
18.08
1tz8D-4ez5A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A  51
LEU A 100
SER A 103
SER A 136
 C8E  A 403 ( 4.6A)
None
None
None
 0.78A 1tz8C-4fspA:
undetectable
1tz8D-4fspA:
undetectable		 1tz8C-4fspA:
16.95
1tz8D-4fspA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A 186
LEU A 144
SER A 136
SER A 103
 C8E  A 408 (-4.5A)
None
None
None
 0.65A 1tz8C-4fspA:
undetectable
1tz8D-4fspA:
undetectable		 1tz8C-4fspA:
16.95
1tz8D-4fspA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 LYS C 219
ALA C 233
LEU C 235
SER C 188
 None
 0.86A 1tz8C-4g59C:
undetectable
1tz8D-4g59C:
undetectable		 1tz8C-4g59C:
17.32
1tz8D-4g59C:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpv PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
eggerthii) 		PF06321
(P_gingi_FimA) 		4 LEU A 282
ALA A 202
LEU A 204
SER A 244
 None
 0.93A 1tz8C-4gpvA:
4.0
1tz8D-4gpvA:
4.1		 1tz8C-4gpvA:
17.63
1tz8D-4gpvA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 LYS A  34
LEU A 250
LEU A 247
SER A  95
 None
 1.01A 1tz8C-4jypA:
undetectable
1tz8D-4jypA:
undetectable		 1tz8C-4jypA:
18.45
1tz8D-4jypA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis) 		PF00561
(Abhydrolase_1) 		4 LEU A 159
ALA A 263
LEU A 116
SER A 122
 None
 1.05A 1tz8C-4meaA:
undetectable
1tz8D-4meaA:
undetectable		 1tz8C-4meaA:
19.01
1tz8D-4meaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 LEU A 179
ALA A 171
LEU A   7
SER A   5
 None
 1.05A 1tz8C-4n2xA:
undetectable
1tz8D-4n2xA:
undetectable		 1tz8C-4n2xA:
16.50
1tz8D-4n2xA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LYS A 413
ALA A 405
LEU A 403
SER A 338
 None
 1.06A 1tz8C-4nenA:
undetectable
1tz8D-4nenA:
2.2		 1tz8C-4nenA:
8.66
1tz8D-4nenA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaw HEAVY CHAIN OF FAB
FRAGMENT OF
ANTI-HIV1 GP120 V2
MAB 2158

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 141
ALA B 154
SER B 144
SER B 145
 None
 0.93A 1tz8C-4oawB:
undetectable
1tz8D-4oawB:
undetectable		 1tz8C-4oawB:
19.92
1tz8D-4oawB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 4 LEU C 104
ALA C  22
LEU C  18
SER C  17
 None
 1.01A 1tz8C-4ptzC:
undetectable
1tz8D-4ptzC:
undetectable		 1tz8C-4ptzC:
20.30
1tz8D-4ptzC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU B 165
ALA B 168
SER B  50
SER B  49
 None
 0.97A 1tz8C-4q4aB:
undetectable
1tz8D-4q4aB:
undetectable		 1tz8C-4q4aB:
11.87
1tz8D-4q4aB:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A 457
ALA A 766
LEU A 764
SER A 737
 None
 0.87A 1tz8C-4ufcA:
undetectable
1tz8D-4ufcA:
undetectable		 1tz8C-4ufcA:
10.28
1tz8D-4ufcA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.98A 1tz8C-4w65A:
undetectable
1tz8D-4w65A:
undetectable		 1tz8C-4w65A:
20.22
1tz8D-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 4 LEU C 282
ALA C 298
LEU C 285
SER C 288
 None
 1.06A 1tz8C-4wzsC:
undetectable
1tz8D-4wzsC:
undetectable		 1tz8C-4wzsC:
10.68
1tz8D-4wzsC:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 LEU B 435
ALA B 427
LEU B 425
SER B 238
 None
 0.89A 1tz8C-4xmmB:
undetectable
1tz8D-4xmmB:
undetectable		 1tz8C-4xmmB:
12.37
1tz8D-4xmmB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 LEU A 243
ALA A 239
LEU A 181
SER A 179
 None
 0.95A 1tz8C-4xxhA:
undetectable
1tz8D-4xxhA:
undetectable		 1tz8C-4xxhA:
23.53
1tz8D-4xxhA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 LEU A 201
ALA A 199
SER A 203
SER A 205
 None
ON3  A2000 ( 4.5A)
None
None
 1.00A 1tz8C-4z36A:
undetectable
1tz8D-4z36A:
undetectable		 1tz8C-4z36A:
13.79
1tz8D-4z36A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 LEU L 446
ALA L 379
LEU L 374
SER L 370
 None
 0.94A 1tz8C-5a7dL:
undetectable
1tz8D-5a7dL:
undetectable		 1tz8C-5a7dL:
15.90
1tz8D-5a7dL:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 LEU A1305
ALA A1325
SER A1327
SER A1330
 None
 1.02A 1tz8C-5cs4A:
undetectable
1tz8D-5cs4A:
undetectable		 1tz8C-5cs4A:
15.13
1tz8D-5cs4A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.06A 1tz8C-5dllA:
undetectable
1tz8D-5dllA:
undetectable		 1tz8C-5dllA:
9.56
1tz8D-5dllA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LYS A 276
LEU A 290
ALA A 345
LEU A 343
 SO4  A 600 (-3.1A)
None
None
None
 1.06A 1tz8C-5jm7A:
undetectable
1tz8D-5jm7A:
undetectable		 1tz8C-5jm7A:
14.26
1tz8D-5jm7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 LYS A 620
LEU A 624
LEU A 626
SER A 627
 None
 0.92A 1tz8C-5kqiA:
undetectable
1tz8D-5kqiA:
undetectable		 1tz8C-5kqiA:
12.89
1tz8D-5kqiA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 4 LEU A 448
ALA A 364
LEU A 366
SER A 350
 None
 0.72A 1tz8C-5lj6A:
undetectable
1tz8D-5lj6A:
undetectable		 1tz8C-5lj6A:
10.86
1tz8D-5lj6A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		4 LYS A 207
LEU A 209
SER A 189
SER A 175
 None
 0.97A 1tz8C-5m23A:
undetectable
1tz8D-5m23A:
undetectable		 1tz8C-5m23A:
14.99
1tz8D-5m23A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		4 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.65A 1tz8C-5mq6A:
undetectable
1tz8D-5mq6A:
undetectable		 1tz8C-5mq6A:
12.82
1tz8D-5mq6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		4 LEU A 575
ALA A 542
LEU A 544
SER A 552
 None
 0.99A 1tz8C-5mqoA:
undetectable
1tz8D-5mqoA:
undetectable		 1tz8C-5mqoA:
9.61
1tz8D-5mqoA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 LEU A 755
LEU A 718
SER A 695
SER A 678
 None
 0.95A 1tz8C-5mtzA:
undetectable
1tz8D-5mtzA:
undetectable		 1tz8C-5mtzA:
10.04
1tz8D-5mtzA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 4 LEU B 232
ALA B 182
LEU B 184
SER B 154
 None
 0.94A 1tz8C-5my0B:
undetectable
1tz8D-5my0B:
undetectable		 1tz8C-5my0B:
20.16
1tz8D-5my0B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4g HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 126
ALA H 139
SER H 129
SER H 130
 None
 1.02A 1tz8C-5n4gH:
4.1
1tz8D-5n4gH:
undetectable		 1tz8C-5n4gH:
21.24
1tz8D-5n4gH:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula) 		no annotation 4 LEU A  11
ALA A  36
SER A  38
SER A  40
 None
 1.06A 1tz8C-5nzbA:
undetectable
1tz8D-5nzbA:
undetectable		 1tz8C-5nzbA:
22.46
1tz8D-5nzbA:
22.46