SIMILAR PATTERNS OF AMINO ACIDS FOR 1TZ8_B_DESB128

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  21
ALA A  24
SER A 202
LEU A 163
LEU A 166
 None
 1.10A 1tz8A-1axdA:
undetectable
1tz8B-1axdA:
undetectable		 1tz8A-1axdA:
20.57
1tz8B-1axdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 163
LEU A 166
LEU A  21
ALA A  24
SER A 202
 None
 1.13A 1tz8A-1axdA:
undetectable
1tz8B-1axdA:
undetectable		 1tz8A-1axdA:
20.57
1tz8B-1axdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cy9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac) 		5 ALA A 417
LEU A 459
LEU A 261
ALA A 224
THR A 226
 None
 1.31A 1tz8A-1cy9A:
0.0
1tz8B-1cy9A:
0.0		 1tz8A-1cy9A:
18.25
1tz8B-1cy9A:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.76A 1tz8A-1gkeA:
21.6
1tz8B-1gkeA:
21.8		 1tz8A-1gkeA:
83.33
1tz8B-1gkeA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.75A 1tz8A-1gkeA:
21.6
1tz8B-1gkeA:
21.8		 1tz8A-1gkeA:
83.33
1tz8B-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 ALA A  94
LEU A  91
ALA A  81
LEU A  65
THR A  86
 None
 1.31A 1tz8A-1sc6A:
0.0
1tz8B-1sc6A:
0.0		 1tz8A-1sc6A:
17.58
1tz8B-1sc6A:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
 None
 0.78A 1tz8A-1sn2A:
20.3
1tz8B-1sn2A:
20.6		 1tz8A-1sn2A:
54.62
1tz8B-1sn2A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.69A 1tz8A-1tfpA:
19.2
1tz8B-1tfpA:
19.4		 1tz8A-1tfpA:
73.85
1tz8B-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 None
 0.77A 1tz8A-1tfpA:
19.2
1tz8B-1tfpA:
19.4		 1tz8A-1tfpA:
73.85
1tz8B-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI

(Homo sapiens) 		PF00106
(adh_short) 		5 LEU A  35
LEU A 112
ALA A 149
LEU A 151
THR A 146
 None
None
None
AOI  A 602 ( 4.6A)
None
 1.20A 1tz8A-1yb1A:
undetectable
1tz8B-1yb1A:
undetectable		 1tz8A-1yb1A:
19.71
1tz8B-1yb1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 684
ALA A 649
LEU A 651
SER A 596
LEU A 713
 None
 1.28A 1tz8A-1yr2A:
0.4
1tz8B-1yr2A:
0.5		 1tz8A-1yr2A:
11.34
1tz8B-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 713
LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 1.29A 1tz8A-1yr2A:
0.4
1tz8B-1yr2A:
0.5		 1tz8A-1yr2A:
11.34
1tz8B-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z23 CRK-ASSOCIATED
SUBSTRATE

(Rattus
norvegicus) 		PF08824
(Serine_rich) 		5 ALA A 620
LEU A 617
LEU A 561
ALA A 688
LEU A 564
 None
 1.24A 1tz8A-1z23A:
undetectable
1tz8B-1z23A:
undetectable		 1tz8A-1z23A:
21.05
1tz8B-1z23A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 LEU B  35
ALA B 111
LEU B  70
LEU B  67
SER B  63
 None
None
HEM  B 200 (-3.8A)
None
None
 1.08A 1tz8A-2d2nB:
undetectable
1tz8B-2d2nB:
undetectable		 1tz8A-2d2nB:
20.26
1tz8B-2d2nB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 LEU B  70
LEU B  67
SER B  63
LEU B  35
ALA B 111
 HEM  B 200 (-3.8A)
None
None
None
None
 1.08A 1tz8A-2d2nB:
undetectable
1tz8B-2d2nB:
undetectable		 1tz8A-2d2nB:
20.26
1tz8B-2d2nB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 LEU A 150
ALA A 167
LEU A 163
LEU A 198
LEU A 193
 None
 1.17A 1tz8A-2dbyA:
undetectable
1tz8B-2dbyA:
undetectable		 1tz8A-2dbyA:
15.38
1tz8B-2dbyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 LEU A  49
LEU A 405
ALA A  47
LEU A 404
THR A 250
 None
 1.27A 1tz8A-2gsnA:
undetectable
1tz8B-2gsnA:
undetectable		 1tz8A-2gsnA:
14.91
1tz8B-2gsnA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A 356
ALA A 379
LEU A 366
ALA A 348
THR A 352
 None
 1.22A 1tz8A-2hv2A:
undetectable
1tz8B-2hv2A:
undetectable		 1tz8A-2hv2A:
16.62
1tz8B-2hv2A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmd PROSPERO HOMEOBOX
PROTEIN 1

(Homo sapiens) 		PF05044
(HPD) 		5 LYS A  24
ALA A  25
LEU A  40
SER A  36
THR A  32
 None
 1.20A 1tz8A-2lmdA:
undetectable
1tz8B-2lmdA:
undetectable		 1tz8A-2lmdA:
21.86
1tz8B-2lmdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 122
LEU A 105
ALA A  87
LEU A  85
THR A  90
 None
 1.19A 1tz8A-2ppgA:
undetectable
1tz8B-2ppgA:
undetectable		 1tz8A-2ppgA:
15.40
1tz8B-2ppgA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 LEU A 159
ALA A 314
LEU A 217
LEU A 306
SER A 224
 None
 1.29A 1tz8A-2qzxA:
undetectable
1tz8B-2qzxA:
undetectable		 1tz8A-2qzxA:
18.81
1tz8B-2qzxA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		5 LEU A 157
LEU A 154
LEU A  31
LEU A  35
SER A  36
 None
None
BR  A1293 ( 4.6A)
None
None
 1.17A 1tz8A-2ykfA:
1.3
1tz8B-2ykfA:
1.4		 1tz8A-2ykfA:
19.35
1tz8B-2ykfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 320
ALA A 353
SER A 355
LEU A 380
SER A 377
 None
 1.31A 1tz8A-3bgwA:
undetectable
1tz8B-3bgwA:
undetectable		 1tz8A-3bgwA:
16.90
1tz8B-3bgwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 380
SER A 377
LEU A 320
ALA A 353
SER A 355
 None
 1.30A 1tz8A-3bgwA:
undetectable
1tz8B-3bgwA:
undetectable		 1tz8A-3bgwA:
16.90
1tz8B-3bgwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		5 LEU A 320
ALA A 353
SER A 355
LEU A 380
SER A 377
 None
 1.22A 1tz8A-3bh0A:
undetectable
1tz8B-3bh0A:
undetectable		 1tz8A-3bh0A:
19.41
1tz8B-3bh0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		5 LEU A 380
SER A 377
LEU A 320
ALA A 353
SER A 355
 None
 1.19A 1tz8A-3bh0A:
undetectable
1tz8B-3bh0A:
undetectable		 1tz8A-3bh0A:
19.41
1tz8B-3bh0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 ALA A 373
LEU A 206
LEU A  93
LEU A  99
SER A 101
 None
 1.17A 1tz8A-3c0kA:
undetectable
1tz8B-3c0kA:
undetectable		 1tz8A-3c0kA:
17.49
1tz8B-3c0kA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 LEU A  93
LEU A  99
SER A 101
ALA A 373
LEU A 206
 None
 1.18A 1tz8A-3c0kA:
undetectable
1tz8B-3c0kA:
undetectable		 1tz8A-3c0kA:
17.49
1tz8B-3c0kA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 ALA A 162
LEU A 160
LEU A  91
LEU A  94
SER A  98
 None
 1.29A 1tz8A-3caiA:
undetectable
1tz8B-3caiA:
undetectable		 1tz8A-3caiA:
15.82
1tz8B-3caiA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjw COUP TRANSCRIPTION
FACTOR 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 320
LEU A 252
LEU A 367
LEU A 370
THR A 248
 None
 1.31A 1tz8A-3cjwA:
undetectable
1tz8B-3cjwA:
undetectable		 1tz8A-3cjwA:
19.38
1tz8B-3cjwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		5 ALA B  57
ALA B 163
LEU B 142
SER B 161
THR B 231
 None
None
None
NAG  B1233 ( 4.6A)
None
 1.02A 1tz8A-3f8uB:
4.3
1tz8B-3f8uB:
3.8		 1tz8A-3f8uB:
15.36
1tz8B-3f8uB:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.74A 1tz8A-3fc8A:
23.3
1tz8B-3fc8A:
23.5		 1tz8A-3fc8A:
100.00
1tz8B-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
 0.73A 1tz8A-3fc8A:
23.3
1tz8B-3fc8A:
23.5		 1tz8A-3fc8A:
100.00
1tz8B-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3

(uncultured
bacterium) 		PF00583
(Acetyltransf_1) 		5 ALA A  56
LEU A  96
ALA A 100
LEU A   1
THR A 103
 None
 1.26A 1tz8A-3fynA:
undetectable
1tz8B-3fynA:
undetectable		 1tz8A-3fynA:
20.11
1tz8B-3fynA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 LEU A 334
LEU A 328
LEU A 418
LEU A 398
THR A 454
 None
 1.27A 1tz8A-3higA:
undetectable
1tz8B-3higA:
undetectable		 1tz8A-3higA:
12.64
1tz8B-3higA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 5 LEU A  59
LEU A 110
SER A 109
LEU A 276
LEU A 279
 None
 1.31A 1tz8A-3i9wA:
undetectable
1tz8B-3i9wA:
undetectable		 1tz8A-3i9wA:
18.06
1tz8B-3i9wA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 5 LEU A 276
LEU A 279
LEU A  59
LEU A 110
SER A 109
 None
 1.31A 1tz8A-3i9wA:
undetectable
1tz8B-3i9wA:
undetectable		 1tz8A-3i9wA:
18.06
1tz8B-3i9wA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keb PROBABLE THIOL
PEROXIDASE

(Chromobacterium
violaceum) 		no annotation 5 LEU A 108
ALA A  97
LEU A  94
SER A  93
THR A  87
 None
 1.27A 1tz8A-3kebA:
undetectable
1tz8B-3kebA:
undetectable		 1tz8A-3kebA:
20.81
1tz8B-3kebA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Cytophaga
hutchinsonii) 		PF02769
(AIRS_C) 		5 LEU A  64
LEU A 261
SER A 262
LEU A 320
LEU A 259
 None
 1.24A 1tz8A-3kizA:
undetectable
1tz8B-3kizA:
undetectable		 1tz8A-3kizA:
16.92
1tz8B-3kizA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Cytophaga
hutchinsonii) 		PF02769
(AIRS_C) 		5 LEU A 320
LEU A 259
LEU A  64
LEU A 261
SER A 262
 None
 1.23A 1tz8A-3kizA:
undetectable
1tz8B-3kizA:
undetectable		 1tz8A-3kizA:
16.92
1tz8B-3kizA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS

(Caldanaerobacter
subterraneus) 		PF00381
(PTS-HPr) 		5 LEU A  77
ALA A  65
LEU A  63
LYS A  45
ALA A  44
 None
 1.15A 1tz8A-3le1A:
undetectable
1tz8B-3le1A:
undetectable		 1tz8A-3le1A:
24.22
1tz8B-3le1A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS

(Caldanaerobacter
subterraneus) 		PF00381
(PTS-HPr) 		5 LYS A  45
ALA A  44
LEU A  77
ALA A  65
LEU A  63
 None
 1.14A 1tz8A-3le1A:
undetectable
1tz8B-3le1A:
undetectable		 1tz8A-3le1A:
24.22
1tz8B-3le1A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		5 LEU A 220
LEU A 189
LEU A 201
ALA A 232
THR A 191
 None
 1.15A 1tz8A-3mgaA:
1.5
1tz8B-3mgaA:
2.2		 1tz8A-3mgaA:
16.09
1tz8B-3mgaA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		5 ALA B1431
LEU B1423
SER B1425
LEU B1416
LEU B1418
 None
 1.27A 1tz8A-3myrB:
undetectable
1tz8B-3myrB:
undetectable		 1tz8A-3myrB:
13.51
1tz8B-3myrB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzl PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C) 		5 ALA B 526
LEU B 531
ALA B 543
LEU B 551
SER B 554
 None
 1.28A 1tz8A-3mzlB:
undetectable
1tz8B-3mzlB:
undetectable		 1tz8A-3mzlB:
16.86
1tz8B-3mzlB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzl PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C) 		5 ALA B 543
LEU B 551
SER B 554
ALA B 526
LEU B 531
 None
 1.22A 1tz8A-3mzlB:
undetectable
1tz8B-3mzlB:
undetectable		 1tz8A-3mzlB:
16.86
1tz8B-3mzlB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 ALA X 198
LEU X 194
LEU X 155
ALA X 153
LEU X 217
 None
 1.27A 1tz8A-3pb9X:
undetectable
1tz8B-3pb9X:
undetectable		 1tz8A-3pb9X:
17.43
1tz8B-3pb9X:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU X 155
ALA X 153
LEU X 217
ALA X 198
LEU X 194
 None
 1.25A 1tz8A-3pb9X:
undetectable
1tz8B-3pb9X:
undetectable		 1tz8A-3pb9X:
17.43
1tz8B-3pb9X:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 142
LEU A 146
LEU A 112
ALA A 219
LEU A 216
 None
 1.18A 1tz8A-3popA:
undetectable
1tz8B-3popA:
undetectable		 1tz8A-3popA:
15.02
1tz8B-3popA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 ALA A 435
LEU A 404
LEU A 379
ALA A 377
LEU A 375
 None
 1.24A 1tz8A-3py7A:
undetectable
1tz8B-3py7A:
undetectable		 1tz8A-3py7A:
14.08
1tz8B-3py7A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 LEU A 379
ALA A 377
LEU A 375
ALA A 435
LEU A 404
 None
 1.30A 1tz8A-3py7A:
undetectable
1tz8B-3py7A:
undetectable		 1tz8A-3py7A:
14.08
1tz8B-3py7A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		5 LEU A 138
LEU A 140
LEU A 204
LEU A 149
THR A 151
 None
 1.28A 1tz8A-3qm3A:
undetectable
1tz8B-3qm3A:
undetectable		 1tz8A-3qm3A:
16.71
1tz8B-3qm3A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 ALA A 324
LEU A 234
LEU A 250
LEU A 258
THR A 236
 None
 1.20A 1tz8A-3qp9A:
undetectable
1tz8B-3qp9A:
undetectable		 1tz8A-3qp9A:
13.74
1tz8B-3qp9A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		5 LEU A 114
ALA A  97
LEU A  89
LEU A  29
LEU A  56
 None
 1.29A 1tz8A-3tr1A:
undetectable
1tz8B-3tr1A:
undetectable		 1tz8A-3tr1A:
16.67
1tz8B-3tr1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vlb XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE A

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		5 LEU B 214
ALA B 212
ALA B 100
SER B  66
THR B 204
 None
 1.22A 1tz8A-3vlbB:
undetectable
1tz8B-3vlbB:
undetectable		 1tz8A-3vlbB:
19.20
1tz8B-3vlbB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP

(Bacillus
subtilis) 		PF00494
(SQS_PSY) 		5 LEU A 137
LEU A 140
SER A 230
LEU A 225
ALA A 151
 None
 1.21A 1tz8A-3we9A:
undetectable
1tz8B-3we9A:
undetectable		 1tz8A-3we9A:
19.34
1tz8B-3we9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP

(Bacillus
subtilis) 		PF00494
(SQS_PSY) 		5 LEU A 225
ALA A 151
LEU A 137
LEU A 140
SER A 230
 None
 1.20A 1tz8A-3we9A:
undetectable
1tz8B-3we9A:
undetectable		 1tz8A-3we9A:
19.34
1tz8B-3we9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ALA A 435
SER A 458
LEU A 449
LEU A 445
THR A 411
 None
 1.21A 1tz8A-4bb9A:
undetectable
1tz8B-4bb9A:
undetectable		 1tz8A-4bb9A:
12.12
1tz8B-4bb9A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ALA A  92
LEU A  90
SER A  87
LEU A 122
ALA A 125
 None
 1.10A 1tz8A-4bx0A:
undetectable
1tz8B-4bx0A:
undetectable		 1tz8A-4bx0A:
19.55
1tz8B-4bx0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A 122
ALA A 125
ALA A  92
LEU A  90
SER A  87
 None
 1.08A 1tz8A-4bx0A:
undetectable
1tz8B-4bx0A:
undetectable		 1tz8A-4bx0A:
19.55
1tz8B-4bx0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 479
SER A 463
LEU A 518
SER A 560
THR A 558
 None
 1.25A 1tz8A-4c7vA:
undetectable
1tz8B-4c7vA:
undetectable		 1tz8A-4c7vA:
13.64
1tz8B-4c7vA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		5 LEU A 302
LEU A 299
SER A 295
ALA A 269
THR A 265
 None
 0.98A 1tz8A-4de8A:
undetectable
1tz8B-4de8A:
undetectable		 1tz8A-4de8A:
16.11
1tz8B-4de8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 ALA A 165
LEU A 161
LEU A 124
ALA A 122
LEU A 182
 None
 1.18A 1tz8A-4faiA:
undetectable
1tz8B-4faiA:
undetectable		 1tz8A-4faiA:
18.60
1tz8B-4faiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 LEU A 124
ALA A 122
LEU A 182
ALA A 165
LEU A 161
 None
 1.20A 1tz8A-4faiA:
undetectable
1tz8B-4faiA:
undetectable		 1tz8A-4faiA:
18.60
1tz8B-4faiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 11
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2) 		6 LEU K   5
ALA K   8
LEU K   4
SER K  41
LEU N 174
LEU N 153
 None
 1.32A 1tz8A-4heaK:
undetectable
1tz8B-4heaK:
undetectable		 1tz8A-4heaK:
20.93
1tz8B-4heaK:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 11
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2) 		6 LEU N 174
LEU N 153
LEU K   5
ALA K   8
LEU K   4
SER K  41
 None
 1.33A 1tz8A-4heaN:
undetectable
1tz8B-4heaN:
undetectable		 1tz8A-4heaN:
14.43
1tz8B-4heaN:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 ALA M 202
LEU M 260
ALA M 297
LEU M 263
SER M 267
 None
 1.14A 1tz8A-4heaM:
undetectable
1tz8B-4heaM:
undetectable		 1tz8A-4heaM:
13.33
1tz8B-4heaM:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU M 260
ALA M 297
LEU M 263
SER M 267
ALA M 202
 None
 1.16A 1tz8A-4heaM:
undetectable
1tz8B-4heaM:
undetectable		 1tz8A-4heaM:
13.33
1tz8B-4heaM:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldu AUXIN RESPONSE
FACTOR 5

(Arabidopsis
thaliana) 		PF02362
(B3)
PF06507
(Auxin_resp) 		5 LEU A 102
LEU A 106
ALA A 287
LEU A 130
THR A 288
 None
 1.14A 1tz8A-4lduA:
undetectable
1tz8B-4lduA:
undetectable		 1tz8A-4lduA:
17.39
1tz8B-4lduA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus) 		PF00156
(Pribosyltran) 		5 ALA A  45
LEU A  47
LEU A 153
ALA A 151
LEU A  68
 None
 1.28A 1tz8A-4m0kA:
undetectable
1tz8B-4m0kA:
undetectable		 1tz8A-4m0kA:
18.81
1tz8B-4m0kA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhw GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ALA A  84
LEU A  81
ALA A 170
LEU A 172
THR A 106
 None
 1.28A 1tz8A-4nhwA:
undetectable
1tz8B-4nhwA:
undetectable		 1tz8A-4nhwA:
21.74
1tz8B-4nhwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		5 SER A 293
LEU A 296
ALA A  26
SER A  46
THR A  48
 None
 1.15A 1tz8A-4pmdA:
undetectable
1tz8B-4pmdA:
undetectable		 1tz8A-4pmdA:
14.03
1tz8B-4pmdA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 LEU A  81
ALA A  59
LEU A 272
LEU A 138
SER A 139
 None
 1.18A 1tz8A-4q2eA:
undetectable
1tz8B-4q2eA:
undetectable		 1tz8A-4q2eA:
17.24
1tz8B-4q2eA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 LEU A 272
LEU A 138
SER A 139
LEU A  81
ALA A  59
 None
 1.11A 1tz8A-4q2eA:
undetectable
1tz8B-4q2eA:
undetectable		 1tz8A-4q2eA:
17.24
1tz8B-4q2eA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5w MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		5 LEU A2150
LEU A2147
ALA A2108
LEU A2110
THR A2105
 None
 1.12A 1tz8A-4q5wA:
undetectable
1tz8B-4q5wA:
undetectable		 1tz8A-4q5wA:
24.32
1tz8B-4q5wA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn0 UPF0141 PROTEIN YJDB

(Campylobacter
jejuni) 		PF00884
(Sulfatase) 		5 LEU A 223
LEU A 221
SER A 421
LEU A 503
LEU A 504
 None
 1.07A 1tz8A-4tn0A:
undetectable
1tz8B-4tn0A:
undetectable		 1tz8A-4tn0A:
16.29
1tz8B-4tn0A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn0 UPF0141 PROTEIN YJDB

(Campylobacter
jejuni) 		PF00884
(Sulfatase) 		5 LEU A 503
LEU A 504
LEU A 223
LEU A 221
SER A 421
 None
 1.09A 1tz8A-4tn0A:
undetectable
1tz8B-4tn0A:
undetectable		 1tz8A-4tn0A:
16.29
1tz8B-4tn0A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 260
ALA A 272
LEU A 268
ALA A 230
THR A 227
 None
 1.26A 1tz8A-4uadA:
undetectable
1tz8B-4uadA:
undetectable		 1tz8A-4uadA:
14.71
1tz8B-4uadA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8l ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 SER A 639
LEU A 642
ALA A 357
SER A 379
THR A 381
 None
None
GOL  A1102 (-3.5A)
None
None
 1.25A 1tz8A-4w8lA:
undetectable
1tz8B-4w8lA:
undetectable		 1tz8A-4w8lA:
15.95
1tz8B-4w8lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 ALA A  52
LYS A1094
ALA A1073
SER A1031
THR A1035
 None
 1.22A 1tz8A-4xa2A:
undetectable
1tz8B-4xa2A:
undetectable		 1tz8A-4xa2A:
13.99
1tz8B-4xa2A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 ALA A  60
LEU A  87
ALA A 108
LEU A 106
SER A 102
 None
 1.30A 1tz8A-5bp8A:
undetectable
1tz8B-5bp8A:
undetectable		 1tz8A-5bp8A:
13.12
1tz8B-5bp8A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 LEU A 343
SER A 363
LEU A 338
ALA A 316
THR A 301
 None
 1.19A 1tz8A-5cykA:
undetectable
1tz8B-5cykA:
undetectable		 1tz8A-5cykA:
15.69
1tz8B-5cykA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		5 ALA A 120
SER A 118
ALA A 131
LEU A 157
SER A 156
 None
 1.22A 1tz8A-5hv6A:
undetectable
1tz8B-5hv6A:
undetectable		 1tz8A-5hv6A:
18.55
1tz8B-5hv6A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		5 ALA A 131
LEU A 157
SER A 156
ALA A 120
SER A 118
 None
 1.21A 1tz8A-5hv6A:
undetectable
1tz8B-5hv6A:
undetectable		 1tz8A-5hv6A:
18.55
1tz8B-5hv6A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 193
LEU A 210
LEU A 176
ALA A 179
THR A 156
 None
 1.27A 1tz8A-5lewA:
undetectable
1tz8B-5lewA:
undetectable		 1tz8A-5lewA:
9.89
1tz8B-5lewA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 ALA A 215
LEU A 211
LEU A 177
LEU A 174
THR A 169
 None
 1.31A 1tz8A-5m42A:
undetectable
1tz8B-5m42A:
undetectable		 1tz8A-5m42A:
18.86
1tz8B-5m42A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owg PCYX_EBK42635

(marine
metagenome) 		no annotation 5 LEU A  54
ALA A  68
LEU A  70
LEU A   6
THR A  13
 None
 1.30A 1tz8A-5owgA:
undetectable
1tz8B-5owgA:
undetectable		 1tz8A-5owgA:
19.01
1tz8B-5owgA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		5 LEU A 143
ALA A 146
LEU A 142
LEU A 196
LEU A 159
 None
 1.26A 1tz8A-5tcbA:
undetectable
1tz8B-5tcbA:
undetectable		 1tz8A-5tcbA:
19.86
1tz8B-5tcbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		5 LEU A 196
LEU A 159
LEU A 143
ALA A 146
LEU A 142
 None
 1.31A 1tz8A-5tcbA:
undetectable
1tz8B-5tcbA:
undetectable		 1tz8A-5tcbA:
19.86
1tz8B-5tcbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3

(Pseudomonas
aeruginosa) 		PF09615
(Cas_Csy3) 		5 LEU C  37
LEU C 214
ALA C 154
LEU C 217
SER C 220
 None
 1.24A 1tz8A-5uz9C:
0.0
1tz8B-5uz9C:
undetectable		 1tz8A-5uz9C:
17.11
1tz8B-5uz9C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3

(Pseudomonas
aeruginosa) 		PF09615
(Cas_Csy3) 		5 LEU C 214
ALA C 154
LEU C 217
SER C 220
LEU C  37
 None
 1.28A 1tz8A-5uz9C:
0.0
1tz8B-5uz9C:
undetectable		 1tz8A-5uz9C:
17.11
1tz8B-5uz9C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xww AMPHB

(Streptomyces
nodosus) 		no annotation 5 ALA A 301
LEU A 222
LEU A 238
LEU A 246
THR A 224
 None
 1.17A 1tz8A-5xwwA:
undetectable
1tz8B-5xwwA:
undetectable		 1tz8A-5xwwA:
22.05
1tz8B-5xwwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2

(Mycobacterium
marinum) 		no annotation 5 LEU A 382
LEU A 276
LEU A 273
SER A 270
THR A 268
 None
None
None
None
HEM  A 501 ( 4.7A)
 1.30A 1tz8A-6bldA:
undetectable
1tz8B-6bldA:
undetectable		 1tz8A-6bldA:
22.83
1tz8B-6bldA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A1531
ALA A1539
LEU A 824
LEU A 827
SER A 830
 None
 1.24A 1tz8A-6emkA:
undetectable
1tz8B-6emkA:
undetectable		 1tz8A-6emkA:
20.00
1tz8B-6emkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 214
ALA B 223
ALA B 257
LEU B 279
SER B 262
 None
 1.23A 1tz8A-6emkB:
undetectable
1tz8B-6emkB:
undetectable		 1tz8A-6emkB:
21.74
1tz8B-6emkB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 265
ALA B 257
LEU B 279
SER B 262
ALA B 223
 None
 1.20A 1tz8A-6emkB:
undetectable
1tz8B-6emkB:
undetectable		 1tz8A-6emkB:
21.74
1tz8B-6emkB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIQ
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica) 		no annotation 5 LEU F 204
LEU F 211
SER F 212
LEU G  29
SER G  36
 None
 1.15A 1tz8A-6f2dF:
undetectable
1tz8B-6f2dF:
undetectable		 1tz8A-6f2dF:
22.22
1tz8B-6f2dF:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIQ
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica) 		no annotation 5 LEU G  29
SER G  36
LEU F 204
LEU F 211
SER F 212
 None
 1.13A 1tz8A-6f2dG:
undetectable
1tz8B-6f2dG:
undetectable		 1tz8A-6f2dG:
23.20
1tz8B-6f2dG:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 5 ALA A 459
LEU A 518
ALA A 494
LEU A 484
SER A 492
 None
 1.22A 1tz8A-6fq3A:
undetectable
1tz8B-6fq3A:
3.6		 1tz8A-6fq3A:
20.61
1tz8B-6fq3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 5 LEU A 518
ALA A 494
LEU A 484
SER A 492
ALA A 459
 None
 1.25A 1tz8A-6fq3A:
undetectable
1tz8B-6fq3A:
3.6		 1tz8A-6fq3A:
20.61
1tz8B-6fq3A:
20.61