SIMILAR PATTERNS OF AMINO ACIDS FOR 1TYR_A_9CRA131_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f80 | HOLO-(ACYL CARRIERPROTEIN) SYNTHASE (Bacillussubtilis) |
PF01648(ACPS) | 4 | LEU A 7ALA A 111SER A 102THR A 104 | NoneNoneNone NA A1255 (-3.8A) | 0.59A | 1tyrA-1f80A:undetectable | 1tyrA-1f80A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggp | PROTEIN (LECTIN 1 ACHAIN) (Trichosantheskirilowii) |
PF00161(RIP) | 4 | LEU A 201ALA A 217SER A 193THR A 218 | None | 1.24A | 1tyrA-1ggpA:0.0 | 1tyrA-1ggpA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gk2 | HISTIDINEAMMONIA-LYASE (Pseudomonasputida) |
PF00221(Lyase_aromatic) | 4 | LEU A 341ALA A 204LEU A 208THR A 201 | None | 1.24A | 1tyrA-1gk2A:undetectable | 1tyrA-1gk2A:13.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gke | TRANSTHYRETIN (Rattusnorvegicus) |
PF00576(Transthyretin) | 4 | LEU A 17ALA A 108LEU A 110THR A 119 | None | 0.31A | 1tyrA-1gkeA:21.7 | 1tyrA-1gkeA:83.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1guq | GALACTOSE-1-PHOSPHATEURIDYLYLTRANSFERASE (Escherichiacoli) |
PF01087(GalP_UDP_transf)PF02744(GalP_UDP_tr_C) | 4 | LEU A 119LEU A 122SER A 123THR A 128 | None | 1.27A | 1tyrA-1guqA:undetectable | 1tyrA-1guqA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hk7 | HEAT SHOCK PROTEINHSP82 (Saccharomycescerevisiae) |
PF00183(HSP90) | 4 | LEU A 491LEU A 488SER A 485THR A 525 | None | 1.27A | 1tyrA-1hk7A:0.1 | 1tyrA-1hk7A:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 4 | LEU A 577ALA A 73SER A 573THR A 74 | None | 1.16A | 1tyrA-1j1wA:3.3 | 1tyrA-1j1wA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 4 | LEU A 577LEU A 571SER A 573THR A 75 | None | 1.28A | 1tyrA-1j1wA:3.3 | 1tyrA-1j1wA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmy | BILE-SALT-ACTIVATEDLIPASE (Homo sapiens) |
PF00135(COesterase) | 4 | LYS A 361LEU A 357ALA A 360THR A 352 | None | 0.94A | 1tyrA-1jmyA:0.0 | 1tyrA-1jmyA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkh | MEVALONATE KINASE (Methanocaldococcusjannaschii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 4 | LYS A 86ALA A 84LEU A 144THR A 121 | None | 1.27A | 1tyrA-1kkhA:undetectable | 1tyrA-1kkhA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qh5 | PROTEIN(HYDROXYACYLGLUTATHIONE HYDROLASE) (Homo sapiens) |
PF00753(Lactamase_B)PF16123(HAGH_C) | 4 | LYS A 201LEU A 197ALA A 200THR A 210 | None | 1.18A | 1tyrA-1qh5A:undetectable | 1tyrA-1qh5A:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r5j | PUTATIVEPHOSPHOTRANSACETYLASE (Streptococcuspyogenes) |
PF01515(PTA_PTB) | 4 | LEU A 182ALA A 186SER A 152THR A 189 | None | 1.19A | 1tyrA-1r5jA:undetectable | 1tyrA-1r5jA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rcq | CATABOLIC ALANINERACEMASE DADX (Pseudomonasaeruginosa) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 4 | LEU A 225ALA A 20LEU A 197SER A 193 | NoneNoneNonePLP A 358 (-2.6A) | 1.29A | 1tyrA-1rcqA:undetectable | 1tyrA-1rcqA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb3 | 4-HYDROXYBENZOYL-COAREDUCTASE BETASUBUNIT (Thaueraaromatica) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 4 | LEU B 252ALA B 240LEU B 242SER B 219 | None | 0.85A | 1tyrA-1sb3B:undetectable | 1tyrA-1sb3B:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sjj | ACTININ (Gallus gallus) |
PF00307(CH)PF00435(Spectrin)PF08726(EFhand_Ca_insen) | 4 | LEU A 505ALA A 426LEU A 428SER A 429 | None | 1.23A | 1tyrA-1sjjA:undetectable | 1tyrA-1sjjA:8.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1sn2 | TRANSTHYRETIN (Sparus aurata) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17ALA A 108LEU A 110THR A 119 | None | 0.54A | 1tyrA-1sn2A:19.7 | 1tyrA-1sn2A:54.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t4n | RIBONUCLEASE III (Saccharomycescerevisiae) |
PF00035(dsrm) | 4 | LYS A 443ALA A 446LEU A 377SER A 376 | None | 0.98A | 1tyrA-1t4nA:undetectable | 1tyrA-1t4nA:22.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tfp | TRANSTHYRETIN (Gallus gallus) |
PF00576(Transthyretin) | 6 | LYS A 15LEU A 17ALA A 108LEU A 110SER A 117THR A 119 | None | 0.47A | 1tyrA-1tfpA:18.7 | 1tyrA-1tfpA:73.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3d | CRYPTOCHROME 1APOPROTEIN (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 4 | LEU A 315LEU A 407SER A 410THR A 404 | None | 1.22A | 1tyrA-1u3dA:undetectable | 1tyrA-1u3dA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uun | MSPA (Mycolicibacteriumsmegmatis) |
PF09203(MspA) | 4 | LEU A 62ALA A 164LEU A 166THR A 176 | None | 0.57A | 1tyrA-1uunA:3.6 | 1tyrA-1uunA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5j | KIAA1355 PROTEIN (Homo sapiens) |
PF00041(fn3) | 4 | LEU A 42LEU A 80SER A 92THR A 94 | None | 1.27A | 1tyrA-1v5jA:3.1 | 1tyrA-1v5jA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vme | FLAVOPROTEIN (Thermotogamaritima) |
PF00258(Flavodoxin_1) | 4 | LYS A 46LEU A 44LEU A 53THR A 79 | None | 1.27A | 1tyrA-1vmeA:undetectable | 1tyrA-1vmeA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xg2 | PECTINESTERASE 1 (Solanumlycopersicum) |
PF01095(Pectinesterase) | 4 | LYS A 107ALA A 103LEU A 71THR A 102 | None | 1.12A | 1tyrA-1xg2A:undetectable | 1tyrA-1xg2A:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xvy | SFUA (Yersiniaenterocolitica) |
PF13343(SBP_bac_6) | 4 | LYS A 163LEU A 159ALA A 306LEU A 302 | None | 1.25A | 1tyrA-1xvyA:undetectable | 1tyrA-1xvyA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2apn | PROTEIN HI1723 (Haemophilusinfluenzae) |
PF01521(Fe-S_biosyn) | 4 | LYS A 18LEU A 33ALA A 15THR A 12 | None | 1.23A | 1tyrA-2apnA:undetectable | 1tyrA-2apnA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqi | RASGTPASE-ACTIVATINGPROTEIN 1 (Homo sapiens) |
PF00018(SH3_1) | 4 | LYS A 29LEU A 14ALA A 12LEU A 61 | None | 1.31A | 1tyrA-2gqiA:undetectable | 1tyrA-2gqiA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o9a | ACETATE OPERONREPRESSOR (Escherichiacoli) |
PF01614(IclR) | 4 | LEU A 72LEU A 75SER A 76THR A 81 | None | 1.27A | 1tyrA-2o9aA:undetectable | 1tyrA-2o9aA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qnw | ACYL CARRIER PROTEIN (Toxoplasmagondii) |
PF00550(PP-binding) | 4 | LYS A 13LEU A 9LEU A 74THR A 69 | NoneNoneNone ZN A 86 ( 4.3A) | 1.13A | 1tyrA-2qnwA:undetectable | 1tyrA-2qnwA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9u | MSPA (Mycolicibacteriumsmegmatis) |
PF09203(MspA) | 4 | LEU A 62ALA A 164LEU A 166THR A 176 | LEU A 62 ( 0.5A)ALA A 164 ( 0.0A)LEU A 166 ( 0.5A)THR A 176 ( 0.8A) | 0.54A | 1tyrA-2v9uA:3.6 | 1tyrA-2v9uA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6d | DYNAMIN FAMILYPROTEIN (Nostocpunctiforme) |
PF00350(Dynamin_N) | 4 | LEU A 49ALA A 38LEU A 51THR A 34 | None | 0.72A | 1tyrA-2w6dA:undetectable | 1tyrA-2w6dA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyd | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 4 | LEU A 306ALA A 538LEU A 304SER A 533 | None | 1.18A | 1tyrA-2xydA:undetectable | 1tyrA-2xydA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6g | B-CATENIN (Danio rerio) |
PF00514(Arm) | 4 | LEU A 639ALA A 655LEU A 642THR A 652 | None | 1.13A | 1tyrA-2z6gA:undetectable | 1tyrA-2z6gA:8.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb5 | STRESS RESPONSIVEALPHA-BETA PROTEIN (Jannaschia sp.CCS1) |
PF07876(Dabb) | 4 | LEU A 33ALA A 67LEU A 36THR A 63 | None | 1.30A | 1tyrA-3bb5A:undetectable | 1tyrA-3bb5A:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bws | PROTEIN LP49 (Leptospirainterrogans) |
PF10282(Lactonase) | 4 | LYS A 76LEU A 78LEU A 86SER A 57 | None | 1.15A | 1tyrA-3bwsA:undetectable | 1tyrA-3bwsA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctm | CARBONYL REDUCTASE (Candidaparapsilosis) |
PF13561(adh_short_C2) | 4 | LEU A 167ALA A 117SER A 38THR A 40 | None | 1.07A | 1tyrA-3ctmA:undetectable | 1tyrA-3ctmA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1r | FRUCTOSE-1,6-BISPHOSPHATASE CLASS IIGLPX (Escherichiacoli) |
PF03320(FBPase_glpX) | 4 | ALA A 102LEU A 104SER A 281THR A 283 | None | 0.52A | 1tyrA-3d1rA:undetectable | 1tyrA-3d1rA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3deg | GTP-BINDING PROTEINLEPA (Escherichiacoli) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF06421(LepA_C) | 4 | LYS C 283ALA C 284SER C 227THR C 273 | None | 1.20A | 1tyrA-3degC:undetectable | 1tyrA-3degC:13.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fc8 | TRANSTHYRETIN (Homo sapiens) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17ALA A 108LEU A 110THR A 119 | IFA A3000 (-3.0A)IFA A3000 ( 4.7A)IFA A3000 (-3.1A)IFA A3000 (-4.1A)IFA A3000 ( 4.9A) | 0.74A | 1tyrA-3fc8A:22.4 | 1tyrA-3fc8A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fc8 | TRANSTHYRETIN (Homo sapiens) |
PF00576(Transthyretin) | 4 | LYS A 15LEU A 17LEU A 110SER A 117 | IFA A3000 (-3.0A)IFA A3000 ( 4.7A)IFA A3000 (-4.1A)IFA A3000 (-3.9A) | 0.98A | 1tyrA-3fc8A:22.4 | 1tyrA-3fc8A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fet | ELECTRON TRANSFERFLAVOPROTEIN SUBUNITALPHA RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF01012(ETF) | 4 | LEU A 100ALA A 71LEU A 19THR A 5 | None | 1.13A | 1tyrA-3fetA:undetectable | 1tyrA-3fetA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gpi | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Methylobacillusflagellatus) |
PF13460(NAD_binding_10) | 4 | LEU A 141ALA A 144LEU A 142SER A 147 | None | 1.31A | 1tyrA-3gpiA:undetectable | 1tyrA-3gpiA:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gve | YFKN PROTEIN (Bacillussubtilis) |
PF00149(Metallophos) | 4 | LEU A 291ALA A 301LEU A 289SER A 303 | None | 1.33A | 1tyrA-3gveA:undetectable | 1tyrA-3gveA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9c | METHIONYL-TRNASYNTHETASE (Escherichiacoli) |
PF09334(tRNA-synt_1g) | 4 | LEU A 8ALA A 287LEU A 289SER A 318 | None | 1.22A | 1tyrA-3h9cA:undetectable | 1tyrA-3h9cA:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hqm | SPECKLE-TYPE POZPROTEIN (Homo sapiens) |
PF00917(MATH) | 4 | LEU A 88LEU A 69SER A 54THR A 56 | NoneNoneSO4 A 4 (-4.4A)None | 1.12A | 1tyrA-3hqmA:undetectable | 1tyrA-3hqmA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i44 | ALDEHYDEDEHYDROGENASE (Bartonellahenselae) |
PF00171(Aldedh) | 4 | LEU A 173LEU A 146SER A 224THR A 226 | None | 0.67A | 1tyrA-3i44A:undetectable | 1tyrA-3i44A:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4e | ISOCITRATE LYASE (Burkholderiapseudomallei) |
PF00463(ICL) | 4 | LEU A 56ALA A 149LEU A 53SER A 178 | None | 1.27A | 1tyrA-3i4eA:undetectable | 1tyrA-3i4eA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwk | AMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 4 | LEU A 184LEU A 157SER A 235THR A 237 | None | 0.75A | 1tyrA-3iwkA:undetectable | 1tyrA-3iwkA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iz3 | STRUCTURAL PROTEINVP1 (Cypovirus 1) |
no annotation | 4 | LEU B 537ALA B 556LEU B 588THR B 557 | None | 1.32A | 1tyrA-3iz3B:undetectable | 1tyrA-3iz3B:7.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd3 | PHOSPHOSERINEPHOSPHOHYDROLASE-LIKE PROTEIN (Francisellatularensis) |
PF12710(HAD) | 4 | LEU A 58LEU A 54SER A 53THR A 40 | None | 1.27A | 1tyrA-3kd3A:undetectable | 1tyrA-3kd3A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kg9 | CURK (Lyngbyamajuscula) |
PF14765(PS-DH) | 4 | LEU A1167ALA A1158LEU A1163THR A1203 | None | 1.20A | 1tyrA-3kg9A:undetectable | 1tyrA-3kg9A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n4x | MONOPOLIN COMPLEXSUBUNIT CSM1 (Saccharomycescerevisiae) |
PF12539(Csm1) | 4 | LYS A 119ALA A 135SER A 162THR A 160 | None | 1.04A | 1tyrA-3n4xA:undetectable | 1tyrA-3n4xA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5n | RIBOFLAVIN UPTAKEPROTEIN (Staphylococcusaureus) |
PF12822(ECF_trnsprt) | 4 | LEU A 52ALA A 99LEU A 96THR A 98 | None | 1.18A | 1tyrA-3p5nA:undetectable | 1tyrA-3p5nA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3prx | COBRA VENOM FACTOR (Naja kaouthia) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | LEU B 280LEU B 264SER B 317THR B 319 | None | 0.70A | 1tyrA-3prxB:4.3 | 1tyrA-3prxB:6.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ru8 | EPITOPE SCAFFOLD2BODX43 (Humanimmunodeficiencyvirus;Thermobifidafusca;syntheticconstruct) |
PF01341(Glyco_hydro_6) | 4 | LYS X 190ALA X 189SER X 148THR X 174 | None | 1.08A | 1tyrA-3ru8X:undetectable | 1tyrA-3ru8X:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6s | CERJ (Streptomycestendae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | LEU A 240ALA A 243LEU A 239THR A 187 | None | 0.94A | 1tyrA-3t6sA:undetectable | 1tyrA-3t6sA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty7 | PUTATIVE ALDEHYDEDEHYDROGENASESAV2122 (Staphylococcusaureus) |
PF00171(Aldedh) | 4 | LEU A 169LEU A 142SER A 220THR A 222 | None | 0.70A | 1tyrA-3ty7A:undetectable | 1tyrA-3ty7A:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vab | DIAMINOPIMELATEDECARBOXYLASE 1 (Brucellamelitensis) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 4 | LEU A 69ALA A 79LEU A 72THR A 57 | None | 1.19A | 1tyrA-3vabA:undetectable | 1tyrA-3vabA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vwa | CYTOPLASMIC EXPORTPROTEIN 1 (Saccharomycescerevisiae) |
no annotation | 4 | LEU A 74LEU A 150SER A 139THR A 134 | None | 1.29A | 1tyrA-3vwaA:undetectable | 1tyrA-3vwaA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zre | THIOL PEROXIDASE (Yersiniapseudotuberculosis) |
PF08534(Redoxin) | 4 | LEU A 127ALA A 132LEU A 130SER A 85 | None | 1.18A | 1tyrA-3zreA:undetectable | 1tyrA-3zreA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b4s | BCL-2-LIKE PROTEIN10 (Homo sapiens) |
PF00452(Bcl-2) | 4 | LEU A 130LEU A 16SER A 19THR A 95 | None | 1.03A | 1tyrA-4b4sA:undetectable | 1tyrA-4b4sA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bqm | GLUTAMINASE LIVERISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase) | 4 | LYS A 287LEU A 277SER A 229THR A 225 | None | 1.24A | 1tyrA-4bqmA:undetectable | 1tyrA-4bqmA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ctd | OUTER MEMBRANEPROTEIN G (Escherichiacoli) |
PF09381(Porin_OmpG) | 4 | LEU A 167ALA A 195LEU A 197THR A 210 | NoneNoneNone CL A1274 (-4.2A) | 0.63A | 1tyrA-4ctdA:undetectable | 1tyrA-4ctdA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d9i | DIAMINOPROPIONATEAMMONIA-LYASE (Escherichiacoli) |
PF00291(PALP) | 4 | LYS A 61LEU A 63LEU A 372THR A 225 | None | 1.03A | 1tyrA-4d9iA:undetectable | 1tyrA-4d9iA:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ft2 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Zea mays) |
PF00145(DNA_methylase)PF00385(Chromo)PF01426(BAH) | 4 | LEU A 608ALA A 587LEU A 589SER A 303 | None | 1.03A | 1tyrA-4ft2A:undetectable | 1tyrA-4ft2A:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gos | V-SETDOMAIN-CONTAININGT-CELL ACTIVATIONINHIBITOR 1 (Homo sapiens) |
PF07686(V-set) | 4 | LEU A 115LEU A 54SER A 44THR A 41 | None | 1.13A | 1tyrA-4gosA:3.3 | 1tyrA-4gosA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grh | AMINODEOXYCHORISMATESYNTHASE (Stenotrophomonasmaltophilia) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | LEU A 229LEU A 233SER A 255THR A 410 | None | 1.34A | 1tyrA-4grhA:undetectable | 1tyrA-4grhA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8q | PUTATIVE BETAINEALDEHYDEDEHYROGENASE (Solanumlycopersicum) |
PF00171(Aldedh) | 4 | LEU A 184LEU A 157SER A 235THR A 237 | NoneNoneNoneNAD A 601 (-4.2A) | 0.75A | 1tyrA-4i8qA:undetectable | 1tyrA-4i8qA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ivn | TRANSCRIPTIONALREGULATOR (Vibriovulnificus) |
PF01380(SIS)PF01418(HTH_6) | 4 | LEU A 207ALA A 225LEU A 223THR A 108 | None | 1.16A | 1tyrA-4ivnA:undetectable | 1tyrA-4ivnA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mr0 | PLASMIN ANDFIBRONECTIN-BINDINGPROTEIN A (Streptococcuspneumoniae) |
PF12708(Pectate_lyase_3)PF13229(Beta_helix) | 4 | LYS A 426LEU A 424ALA A 470THR A 503 | None CA A 702 ( 4.5A)NoneNone | 0.83A | 1tyrA-4mr0A:undetectable | 1tyrA-4mr0A:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv1 | FORMYLTRANSFERASE (Francisellatularensis) |
no annotation | 4 | LYS C 65LEU C 62LEU C 82SER C 85 | None | 1.30A | 1tyrA-4nv1C:undetectable | 1tyrA-4nv1C:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4raj | HEME OXYGENASE (Chlamydomonasreinhardtii) |
PF01126(Heme_oxygenase) | 4 | LEU A 21ALA A 139LEU A 208SER A 209 | None | 1.34A | 1tyrA-4rajA:undetectable | 1tyrA-4rajA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4raj | HEME OXYGENASE (Chlamydomonasreinhardtii) |
PF01126(Heme_oxygenase) | 4 | LEU A 90ALA A 149LEU A 184SER A 180 | None | 1.14A | 1tyrA-4rajA:undetectable | 1tyrA-4rajA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4us4 | TRANSPORTER (Bacillushalodurans) |
PF00209(SNF) | 4 | LEU A 239ALA A 26LEU A 234THR A 231 | None NA A 702 ( 4.8A)None NA A 702 ( 3.3A) | 1.24A | 1tyrA-4us4A:undetectable | 1tyrA-4us4A:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjs | RSA4 (Chaetomiumthermophilum) |
PF00400(WD40) | 4 | LEU A 193LEU A 236SER A 257THR A 211 | None | 1.24A | 1tyrA-4wjsA:undetectable | 1tyrA-4wjsA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzs | SIMILARITY TOHELICASE MOT1 (Encephalitozooncuniculi) |
no annotation | 4 | LEU C 462LEU C 431SER C 430THR C 487 | None | 1.30A | 1tyrA-4wzsC:undetectable | 1tyrA-4wzsC:10.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Drosophilamelanogaster) |
PF07034(ORC3_N) | 4 | LEU C 413ALA C 466LEU C 410THR C 470 | None | 1.04A | 1tyrA-4xgcC:undetectable | 1tyrA-4xgcC:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 4 | LEU A 380ALA A 378SER A 389THR A 376 | None | 1.08A | 1tyrA-4zxiA:undetectable | 1tyrA-4zxiA:7.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zyj | DNMZ (Streptomycespeucetius) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | LEU A 78ALA A 25LEU A 29THR A 23 | None | 1.30A | 1tyrA-4zyjA:undetectable | 1tyrA-4zyjA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c92 | KELCHDOMAIN-CONTAININGPROTEIN (Colletotrichumgraminicola) |
PF01344(Kelch_1)PF09118(DUF1929) | 4 | LEU A 28LEU A 21SER A 419THR A 421 | None | 1.13A | 1tyrA-5c92A:1.9 | 1tyrA-5c92A:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dll | AMINOPEPTIDASE N (Francisellatularensis) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 4 | LEU A 763ALA A 749LEU A 745SER A 779 | None | 1.20A | 1tyrA-5dllA:undetectable | 1tyrA-5dllA:9.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7s | LON PROTEASE (Meiothermustaiwanensis) |
PF05362(Lon_C) | 4 | LEU A 769ALA A 597SER A 689THR A 596 | None | 0.98A | 1tyrA-5e7sA:undetectable | 1tyrA-5e7sA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 4 | LEU A 356LEU A 359SER A 361THR A 365 | None | 0.98A | 1tyrA-5fsaA:undetectable | 1tyrA-5fsaA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkf | ENDONUCLEASE ENDOMS (Thermococcuskodakarensis) |
PF01939(NucS) | 4 | LEU A 212ALA A 221SER A 216THR A 218 | None | 1.17A | 1tyrA-5gkfA:undetectable | 1tyrA-5gkfA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzt | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 4 | LEU B 798ALA B 741SER B 791THR B 765 | None | 1.34A | 1tyrA-5gztB:3.6 | 1tyrA-5gztB:7.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzu | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 4 | LEU A 798ALA A 741SER A 791THR A 765 | None | 1.31A | 1tyrA-5gzuA:undetectable | 1tyrA-5gzuA:9.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hpi | P-HYDROXYBENZOATEHYDROXYLASETRANSCRIPTIONALACTIVATOR (Acinetobactersp. ADP1) |
PF01614(IclR) | 4 | LEU A 260ALA A 224LEU A 238THR A 161 | NoneNoneNone3HB A 301 (-3.6A) | 1.00A | 1tyrA-5hpiA:undetectable | 1tyrA-5hpiA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihu | BOVINE FAB B11 HEAVYCHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 4 | LYS H 13LEU H 11SER H 87THR H 84 | None | 0.95A | 1tyrA-5ihuH:4.2 | 1tyrA-5ihuH:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzn | METABOTROPICGLUTAMATE RECEPTOR 2 (Homo sapiens) |
PF01094(ANF_receptor)PF07562(NCD3G) | 4 | LEU A 278ALA A 281LEU A 279SER A 307 | None | 1.29A | 1tyrA-5kznA:undetectable | 1tyrA-5kznA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mgy | FAD:PROTEIN FMNTRANSFERASE (Pseudomonasstutzeri) |
no annotation | 4 | LEU H 177ALA H 174LEU H 164SER H 165 | None | 1.34A | 1tyrA-5mgyH:undetectable | 1tyrA-5mgyH:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 4 | LEU A 608ALA A 524LEU A 49THR A 520 | None | 1.18A | 1tyrA-5nd1A:undetectable | 1tyrA-5nd1A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ng5 | MULTIDRUG EFFLUXPUMP SUBUNIT ACRA (Escherichiacoli) |
no annotation | 4 | LEU E 348ALA E 305LEU E 307THR E 47 | None | 1.20A | 1tyrA-5ng5E:undetectable | 1tyrA-5ng5E:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v4b | F-BOX/WDREPEAT-CONTAININGPROTEIN 7 (Homo sapiens) |
PF00400(WD40)PF12937(F-box-like) | 4 | ALA B2626LEU B2583SER B2585THR B2628 | None | 1.28A | 1tyrA-5v4bB:undetectable | 1tyrA-5v4bB:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w66 | RNA POLYMERASEI-SPECIFICTRANSCRIPTIONINITIATION FACTORRRN7 (Saccharomycescerevisiae) |
no annotation | 4 | LEU P 498LEU P 488SER P 485THR P 481 | None | 1.33A | 1tyrA-5w66P:undetectable | 1tyrA-5w66P:11.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w81 | CYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (Danio rerio) |
PF00005(ABC_tran)PF00664(ABC_membrane)PF14396(CFTR_R) | 4 | LEU A 601ALA A 572LEU A 570SER A 490 | None | 0.84A | 1tyrA-5w81A:undetectable | 1tyrA-5w81A:6.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9g | MAGNESIUMTRANSPORTER MGTE (Thermusthermophilus) |
PF00571(CBS)PF03448(MgtE_N) | 4 | LEU A 61ALA A 70LEU A 64SER A 65 | None | 1.30A | 1tyrA-5x9gA:undetectable | 1tyrA-5x9gA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 4 | LYS C 681ALA C 677LEU C 743THR C 673 | None | 1.34A | 1tyrA-5y3rC:undetectable | 1tyrA-5y3rC:2.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yeu | - (-) |
no annotation | 4 | ALA A 192LEU A 315SER A 196THR A 193 | MG A 602 ( 4.7A)NoneNone MG A 602 ( 4.0A) | 1.12A | 1tyrA-5yeuA:undetectable | 1tyrA-5yeuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbq | NEUROPEPTIDE YRECEPTOR TYPE 1,T4LYSOZYME (Escherichiavirus T4;Homo sapiens) |
no annotation | 4 | LYS A1042LEU A1038ALA A1041SER A1035 | None | 1.27A | 1tyrA-5zbqA:undetectable | 1tyrA-5zbqA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8a | INOSITOLPOLYPHOSPHATEMULTIKINASE (Homo sapiens) |
no annotation | 4 | LYS A 75LEU A 77LEU A 126SER A 118 | None | 1.28A | 1tyrA-6c8aA:undetectable | 1tyrA-6c8aA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6elq | CARBON MONOXIDEDEHYDROGENASE (Carboxydothermushydrogenoformans) |
no annotation | 4 | ALA X 87LEU X 564SER X 565THR X 86 | None | 1.34A | 1tyrA-6elqX:undetectable | 1tyrA-6elqX:21.26 |