SIMILAR PATTERNS OF AMINO ACIDS FOR 1TYR_A_9CRA131

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f80 HOLO-(ACYL CARRIER
PROTEIN) SYNTHASE


(Bacillus
subtilis)
PF01648
(ACPS)
4 LEU A   7
ALA A 111
SER A 102
THR A 104
None
None
None
NA  A1255 (-3.8A)
0.59A 1tyrA-1f80A:
undetectable
1tyrA-1f80A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)


(Trichosanthes
kirilowii)
PF00161
(RIP)
4 LEU A 201
ALA A 217
SER A 193
THR A 218
None
1.24A 1tyrA-1ggpA:
0.0
1tyrA-1ggpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE


(Pseudomonas
putida)
PF00221
(Lyase_aromatic)
4 LEU A 341
ALA A 204
LEU A 208
THR A 201
None
1.24A 1tyrA-1gk2A:
undetectable
1tyrA-1gk2A:
13.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus)
PF00576
(Transthyretin)
4 LEU A  17
ALA A 108
LEU A 110
THR A 119
None
0.31A 1tyrA-1gkeA:
21.7
1tyrA-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE


(Escherichia
coli)
PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C)
4 LEU A 119
LEU A 122
SER A 123
THR A 128
None
1.27A 1tyrA-1guqA:
undetectable
1tyrA-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hk7 HEAT SHOCK PROTEIN
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
4 LEU A 491
LEU A 488
SER A 485
THR A 525
None
1.27A 1tyrA-1hk7A:
0.1
1tyrA-1hk7A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
4 LEU A 577
ALA A  73
SER A 573
THR A  74
None
1.16A 1tyrA-1j1wA:
3.3
1tyrA-1j1wA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
4 LEU A 577
LEU A 571
SER A 573
THR A  75
None
1.28A 1tyrA-1j1wA:
3.3
1tyrA-1j1wA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE


(Homo sapiens)
PF00135
(COesterase)
4 LYS A 361
LEU A 357
ALA A 360
THR A 352
None
0.94A 1tyrA-1jmyA:
0.0
1tyrA-1jmyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 LYS A  86
ALA A  84
LEU A 144
THR A 121
None
1.27A 1tyrA-1kkhA:
undetectable
1tyrA-1kkhA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)


(Homo sapiens)
PF00753
(Lactamase_B)
PF16123
(HAGH_C)
4 LYS A 201
LEU A 197
ALA A 200
THR A 210
None
1.18A 1tyrA-1qh5A:
undetectable
1tyrA-1qh5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E


(Streptococcus
pyogenes)
PF01515
(PTA_PTB)
4 LEU A 182
ALA A 186
SER A 152
THR A 189
None
1.19A 1tyrA-1r5jA:
undetectable
1tyrA-1r5jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX


(Pseudomonas
aeruginosa)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 LEU A 225
ALA A  20
LEU A 197
SER A 193
None
None
None
PLP  A 358 (-2.6A)
1.29A 1tyrA-1rcqA:
undetectable
1tyrA-1rcqA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT


(Thauera
aromatica)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
4 LEU B 252
ALA B 240
LEU B 242
SER B 219
None
0.85A 1tyrA-1sb3B:
undetectable
1tyrA-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus)
PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen)
4 LEU A 505
ALA A 426
LEU A 428
SER A 429
None
1.23A 1tyrA-1sjjA:
undetectable
1tyrA-1sjjA:
8.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata)
PF00576
(Transthyretin)
5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
None
0.54A 1tyrA-1sn2A:
19.7
1tyrA-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4n RIBONUCLEASE III

(Saccharomyces
cerevisiae)
PF00035
(dsrm)
4 LYS A 443
ALA A 446
LEU A 377
SER A 376
None
0.98A 1tyrA-1t4nA:
undetectable
1tyrA-1t4nA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus)
PF00576
(Transthyretin)
6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
None
0.47A 1tyrA-1tfpA:
18.7
1tyrA-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN


(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 LEU A 315
LEU A 407
SER A 410
THR A 404
None
1.22A 1tyrA-1u3dA:
undetectable
1tyrA-1u3dA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis)
PF09203
(MspA)
4 LEU A  62
ALA A 164
LEU A 166
THR A 176
None
0.57A 1tyrA-1uunA:
3.6
1tyrA-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5j KIAA1355 PROTEIN

(Homo sapiens)
PF00041
(fn3)
4 LEU A  42
LEU A  80
SER A  92
THR A  94
None
1.27A 1tyrA-1v5jA:
3.1
1tyrA-1v5jA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima)
PF00258
(Flavodoxin_1)
4 LYS A  46
LEU A  44
LEU A  53
THR A  79
None
1.27A 1tyrA-1vmeA:
undetectable
1tyrA-1vmeA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum)
PF01095
(Pectinesterase)
4 LYS A 107
ALA A 103
LEU A  71
THR A 102
None
1.12A 1tyrA-1xg2A:
undetectable
1tyrA-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica)
PF13343
(SBP_bac_6)
4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
None
1.25A 1tyrA-1xvyA:
undetectable
1tyrA-1xvyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apn PROTEIN HI1723

(Haemophilus
influenzae)
PF01521
(Fe-S_biosyn)
4 LYS A  18
LEU A  33
ALA A  15
THR A  12
None
1.23A 1tyrA-2apnA:
undetectable
1tyrA-2apnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1


(Homo sapiens)
PF00018
(SH3_1)
4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
None
1.31A 1tyrA-2gqiA:
undetectable
1tyrA-2gqiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9a ACETATE OPERON
REPRESSOR


(Escherichia
coli)
PF01614
(IclR)
4 LEU A  72
LEU A  75
SER A  76
THR A  81
None
1.27A 1tyrA-2o9aA:
undetectable
1tyrA-2o9aA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnw ACYL CARRIER PROTEIN

(Toxoplasma
gondii)
PF00550
(PP-binding)
4 LYS A  13
LEU A   9
LEU A  74
THR A  69
None
None
None
ZN  A  86 ( 4.3A)
1.13A 1tyrA-2qnwA:
undetectable
1tyrA-2qnwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis)
PF09203
(MspA)
4 LEU A  62
ALA A 164
LEU A 166
THR A 176
LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
0.54A 1tyrA-2v9uA:
3.6
1tyrA-2v9uA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN


(Nostoc
punctiforme)
PF00350
(Dynamin_N)
4 LEU A  49
ALA A  38
LEU A  51
THR A  34
None
0.72A 1tyrA-2w6dA:
undetectable
1tyrA-2w6dA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
4 LEU A 306
ALA A 538
LEU A 304
SER A 533
None
1.18A 1tyrA-2xydA:
undetectable
1tyrA-2xydA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
4 LEU A 639
ALA A 655
LEU A 642
THR A 652
None
1.13A 1tyrA-2z6gA:
undetectable
1tyrA-2z6gA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb5 STRESS RESPONSIVE
ALPHA-BETA PROTEIN


(Jannaschia sp.
CCS1)
PF07876
(Dabb)
4 LEU A  33
ALA A  67
LEU A  36
THR A  63
None
1.30A 1tyrA-3bb5A:
undetectable
1tyrA-3bb5A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans)
PF10282
(Lactonase)
4 LYS A  76
LEU A  78
LEU A  86
SER A  57
None
1.15A 1tyrA-3bwsA:
undetectable
1tyrA-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctm CARBONYL REDUCTASE

(Candida
parapsilosis)
PF13561
(adh_short_C2)
4 LEU A 167
ALA A 117
SER A  38
THR A  40
None
1.07A 1tyrA-3ctmA:
undetectable
1tyrA-3ctmA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX


(Escherichia
coli)
PF03320
(FBPase_glpX)
4 ALA A 102
LEU A 104
SER A 281
THR A 283
None
0.52A 1tyrA-3d1rA:
undetectable
1tyrA-3d1rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
4 LYS C 283
ALA C 284
SER C 227
THR C 273
None
1.20A 1tyrA-3degC:
undetectable
1tyrA-3degC:
13.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens)
PF00576
(Transthyretin)
5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.74A 1tyrA-3fc8A:
22.4
1tyrA-3fc8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens)
PF00576
(Transthyretin)
4 LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.98A 1tyrA-3fc8A:
22.4
1tyrA-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF01012
(ETF)
4 LEU A 100
ALA A  71
LEU A  19
THR A   5
None
1.13A 1tyrA-3fetA:
undetectable
1tyrA-3fetA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Methylobacillus
flagellatus)
PF13460
(NAD_binding_10)
4 LEU A 141
ALA A 144
LEU A 142
SER A 147
None
1.31A 1tyrA-3gpiA:
undetectable
1tyrA-3gpiA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis)
PF00149
(Metallophos)
4 LEU A 291
ALA A 301
LEU A 289
SER A 303
None
1.33A 1tyrA-3gveA:
undetectable
1tyrA-3gveA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF09334
(tRNA-synt_1g)
4 LEU A   8
ALA A 287
LEU A 289
SER A 318
None
1.22A 1tyrA-3h9cA:
undetectable
1tyrA-3h9cA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqm SPECKLE-TYPE POZ
PROTEIN


(Homo sapiens)
PF00917
(MATH)
4 LEU A  88
LEU A  69
SER A  54
THR A  56
None
None
SO4  A   4 (-4.4A)
None
1.12A 1tyrA-3hqmA:
undetectable
1tyrA-3hqmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE


(Bartonella
henselae)
PF00171
(Aldedh)
4 LEU A 173
LEU A 146
SER A 224
THR A 226
None
0.67A 1tyrA-3i44A:
undetectable
1tyrA-3i44A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4e ISOCITRATE LYASE

(Burkholderia
pseudomallei)
PF00463
(ICL)
4 LEU A  56
ALA A 149
LEU A  53
SER A 178
None
1.27A 1tyrA-3i4eA:
undetectable
1tyrA-3i4eA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE


(Pisum sativum)
PF00171
(Aldedh)
4 LEU A 184
LEU A 157
SER A 235
THR A 237
None
0.75A 1tyrA-3iwkA:
undetectable
1tyrA-3iwkA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1


(Cypovirus 1)
no annotation 4 LEU B 537
ALA B 556
LEU B 588
THR B 557
None
1.32A 1tyrA-3iz3B:
undetectable
1tyrA-3iz3B:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd3 PHOSPHOSERINE
PHOSPHOHYDROLASE-LIK
E PROTEIN


(Francisella
tularensis)
PF12710
(HAD)
4 LEU A  58
LEU A  54
SER A  53
THR A  40
None
1.27A 1tyrA-3kd3A:
undetectable
1tyrA-3kd3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula)
PF14765
(PS-DH)
4 LEU A1167
ALA A1158
LEU A1163
THR A1203
None
1.20A 1tyrA-3kg9A:
undetectable
1tyrA-3kg9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1


(Saccharomyces
cerevisiae)
PF12539
(Csm1)
4 LYS A 119
ALA A 135
SER A 162
THR A 160
None
1.04A 1tyrA-3n4xA:
undetectable
1tyrA-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN


(Staphylococcus
aureus)
PF12822
(ECF_trnsprt)
4 LEU A  52
ALA A  99
LEU A  96
THR A  98
None
1.18A 1tyrA-3p5nA:
undetectable
1tyrA-3p5nA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 LEU B 280
LEU B 264
SER B 317
THR B 319
None
0.70A 1tyrA-3prxB:
4.3
1tyrA-3prxB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43


(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct)
PF01341
(Glyco_hydro_6)
4 LYS X 190
ALA X 189
SER X 148
THR X 174
None
1.08A 1tyrA-3ru8X:
undetectable
1tyrA-3ru8X:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 LEU A 240
ALA A 243
LEU A 239
THR A 187
None
0.94A 1tyrA-3t6sA:
undetectable
1tyrA-3t6sA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122


(Staphylococcus
aureus)
PF00171
(Aldedh)
4 LEU A 169
LEU A 142
SER A 220
THR A 222
None
0.70A 1tyrA-3ty7A:
undetectable
1tyrA-3ty7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1


(Brucella
melitensis)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
4 LEU A  69
ALA A  79
LEU A  72
THR A  57
None
1.19A 1tyrA-3vabA:
undetectable
1tyrA-3vabA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1


(Saccharomyces
cerevisiae)
no annotation 4 LEU A  74
LEU A 150
SER A 139
THR A 134
None
1.29A 1tyrA-3vwaA:
undetectable
1tyrA-3vwaA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zre THIOL PEROXIDASE

(Yersinia
pseudotuberculosis)
PF08534
(Redoxin)
4 LEU A 127
ALA A 132
LEU A 130
SER A  85
None
1.18A 1tyrA-3zreA:
undetectable
1tyrA-3zreA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4s BCL-2-LIKE PROTEIN
10


(Homo sapiens)
PF00452
(Bcl-2)
4 LEU A 130
LEU A  16
SER A  19
THR A  95
None
1.03A 1tyrA-4b4sA:
undetectable
1tyrA-4b4sA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL


(Homo sapiens)
PF04960
(Glutaminase)
4 LYS A 287
LEU A 277
SER A 229
THR A 225
None
1.24A 1tyrA-4bqmA:
undetectable
1tyrA-4bqmA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ctd OUTER MEMBRANE
PROTEIN G


(Escherichia
coli)
PF09381
(Porin_OmpG)
4 LEU A 167
ALA A 195
LEU A 197
THR A 210
None
None
None
CL  A1274 (-4.2A)
0.63A 1tyrA-4ctdA:
undetectable
1tyrA-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE


(Escherichia
coli)
PF00291
(PALP)
4 LYS A  61
LEU A  63
LEU A 372
THR A 225
None
1.03A 1tyrA-4d9iA:
undetectable
1tyrA-4d9iA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Zea mays)
PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH)
4 LEU A 608
ALA A 587
LEU A 589
SER A 303
None
1.03A 1tyrA-4ft2A:
undetectable
1tyrA-4ft2A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1


(Homo sapiens)
PF07686
(V-set)
4 LEU A 115
LEU A  54
SER A  44
THR A  41
None
1.13A 1tyrA-4gosA:
3.3
1tyrA-4gosA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE


(Stenotrophomonas
maltophilia)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
4 LEU A 229
LEU A 233
SER A 255
THR A 410
None
1.34A 1tyrA-4grhA:
undetectable
1tyrA-4grhA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE


(Solanum
lycopersicum)
PF00171
(Aldedh)
4 LEU A 184
LEU A 157
SER A 235
THR A 237
None
None
None
NAD  A 601 (-4.2A)
0.75A 1tyrA-4i8qA:
undetectable
1tyrA-4i8qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivn TRANSCRIPTIONAL
REGULATOR


(Vibrio
vulnificus)
PF01380
(SIS)
PF01418
(HTH_6)
4 LEU A 207
ALA A 225
LEU A 223
THR A 108
None
1.16A 1tyrA-4ivnA:
undetectable
1tyrA-4ivnA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
4 LYS A 426
LEU A 424
ALA A 470
THR A 503
None
CA  A 702 ( 4.5A)
None
None
0.83A 1tyrA-4mr0A:
undetectable
1tyrA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis)
no annotation 4 LYS C  65
LEU C  62
LEU C  82
SER C  85
None
1.30A 1tyrA-4nv1C:
undetectable
1tyrA-4nv1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raj HEME OXYGENASE

(Chlamydomonas
reinhardtii)
PF01126
(Heme_oxygenase)
4 LEU A  21
ALA A 139
LEU A 208
SER A 209
None
1.34A 1tyrA-4rajA:
undetectable
1tyrA-4rajA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raj HEME OXYGENASE

(Chlamydomonas
reinhardtii)
PF01126
(Heme_oxygenase)
4 LEU A  90
ALA A 149
LEU A 184
SER A 180
None
1.14A 1tyrA-4rajA:
undetectable
1tyrA-4rajA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans)
PF00209
(SNF)
4 LEU A 239
ALA A  26
LEU A 234
THR A 231
None
NA  A 702 ( 4.8A)
None
NA  A 702 ( 3.3A)
1.24A 1tyrA-4us4A:
undetectable
1tyrA-4us4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum)
PF00400
(WD40)
4 LEU A 193
LEU A 236
SER A 257
THR A 211
None
1.24A 1tyrA-4wjsA:
undetectable
1tyrA-4wjsA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1


(Encephalitozoon
cuniculi)
no annotation 4 LEU C 462
LEU C 431
SER C 430
THR C 487
None
1.30A 1tyrA-4wzsC:
undetectable
1tyrA-4wzsC:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Drosophila
melanogaster)
PF07034
(ORC3_N)
4 LEU C 413
ALA C 466
LEU C 410
THR C 470
None
1.04A 1tyrA-4xgcC:
undetectable
1tyrA-4xgcC:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
4 LEU A 380
ALA A 378
SER A 389
THR A 376
None
1.08A 1tyrA-4zxiA:
undetectable
1tyrA-4zxiA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 LEU A  78
ALA A  25
LEU A  29
THR A  23
None
1.30A 1tyrA-4zyjA:
undetectable
1tyrA-4zyjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN


(Colletotrichum
graminicola)
PF01344
(Kelch_1)
PF09118
(DUF1929)
4 LEU A  28
LEU A  21
SER A 419
THR A 421
None
1.13A 1tyrA-5c92A:
1.9
1tyrA-5c92A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
4 LEU A 763
ALA A 749
LEU A 745
SER A 779
None
1.20A 1tyrA-5dllA:
undetectable
1tyrA-5dllA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis)
PF05362
(Lon_C)
4 LEU A 769
ALA A 597
SER A 689
THR A 596
None
0.98A 1tyrA-5e7sA:
undetectable
1tyrA-5e7sA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans)
PF00067
(p450)
4 LEU A 356
LEU A 359
SER A 361
THR A 365
None
0.98A 1tyrA-5fsaA:
undetectable
1tyrA-5fsaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkf ENDONUCLEASE ENDOMS

(Thermococcus
kodakarensis)
PF01939
(NucS)
4 LEU A 212
ALA A 221
SER A 216
THR A 218
None
1.17A 1tyrA-5gkfA:
undetectable
1tyrA-5gkfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
4 LEU B 798
ALA B 741
SER B 791
THR B 765
None
1.34A 1tyrA-5gztB:
3.6
1tyrA-5gztB:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
4 LEU A 798
ALA A 741
SER A 791
THR A 765
None
1.31A 1tyrA-5gzuA:
undetectable
1tyrA-5gzuA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR


(Acinetobacter
sp. ADP1)
PF01614
(IclR)
4 LEU A 260
ALA A 224
LEU A 238
THR A 161
None
None
None
3HB  A 301 (-3.6A)
1.00A 1tyrA-5hpiA:
undetectable
1tyrA-5hpiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN


(Bos taurus)
PF07654
(C1-set)
PF07686
(V-set)
4 LYS H  13
LEU H  11
SER H  87
THR H  84
None
0.95A 1tyrA-5ihuH:
4.2
1tyrA-5ihuH:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2


(Homo sapiens)
PF01094
(ANF_receptor)
PF07562
(NCD3G)
4 LEU A 278
ALA A 281
LEU A 279
SER A 307
None
1.29A 1tyrA-5kznA:
undetectable
1tyrA-5kznA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgy FAD:PROTEIN FMN
TRANSFERASE


(Pseudomonas
stutzeri)
no annotation 4 LEU H 177
ALA H 174
LEU H 164
SER H 165
None
1.34A 1tyrA-5mgyH:
undetectable
1tyrA-5mgyH:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 4 LEU A 608
ALA A 524
LEU A  49
THR A 520
None
1.18A 1tyrA-5nd1A:
undetectable
1tyrA-5nd1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA


(Escherichia
coli)
no annotation 4 LEU E 348
ALA E 305
LEU E 307
THR E  47
None
1.20A 1tyrA-5ng5E:
undetectable
1tyrA-5ng5E:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7


(Homo sapiens)
PF00400
(WD40)
PF12937
(F-box-like)
4 ALA B2626
LEU B2583
SER B2585
THR B2628
None
1.28A 1tyrA-5v4bB:
undetectable
1tyrA-5v4bB:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w66 RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN7


(Saccharomyces
cerevisiae)
no annotation 4 LEU P 498
LEU P 488
SER P 485
THR P 481
None
1.33A 1tyrA-5w66P:
undetectable
1tyrA-5w66P:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR


(Danio rerio)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R)
4 LEU A 601
ALA A 572
LEU A 570
SER A 490
None
0.84A 1tyrA-5w81A:
undetectable
1tyrA-5w81A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE


(Thermus
thermophilus)
PF00571
(CBS)
PF03448
(MgtE_N)
4 LEU A  61
ALA A  70
LEU A  64
SER A  65
None
1.30A 1tyrA-5x9gA:
undetectable
1tyrA-5x9gA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
4 LYS C 681
ALA C 677
LEU C 743
THR C 673
None
1.34A 1tyrA-5y3rC:
undetectable
1tyrA-5y3rC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-)
no annotation 4 ALA A 192
LEU A 315
SER A 196
THR A 193
MG  A 602 ( 4.7A)
None
None
MG  A 602 ( 4.0A)
1.12A 1tyrA-5yeuA:
undetectable
1tyrA-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME


(Escherichia
virus T4;
Homo sapiens)
no annotation 4 LYS A1042
LEU A1038
ALA A1041
SER A1035
None
1.27A 1tyrA-5zbqA:
undetectable
1tyrA-5zbqA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE


(Homo sapiens)
no annotation 4 LYS A  75
LEU A  77
LEU A 126
SER A 118
None
1.28A 1tyrA-6c8aA:
undetectable
1tyrA-6c8aA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE


(Carboxydothermus
hydrogenoformans)
no annotation 4 ALA X  87
LEU X 564
SER X 565
THR X  86
None
1.34A 1tyrA-6elqX:
undetectable
1tyrA-6elqX:
21.26