SIMILAR PATTERNS OF AMINO ACIDS FOR 1TW4_B_CHDB1130_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hqo | URE2 PROTEIN (Saccharomycescerevisiae) |
PF00043(GST_C)PF02798(GST_N) | 5 | LEU A 185LEU A 201ILE A 130ARG A 344LEU A 168 | None | 1.27A | 1tw4B-1hqoA:0.0 | 1tw4B-1hqoA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1inp | INOSITOLPOLYPHOSPHATE1-PHOSPHATASE (Bos taurus) |
PF00459(Inositol_P) | 5 | TYR A 220LEU A 296LEU A 302THR A 239ILE A 230 | None | 1.28A | 1tw4B-1inpA:0.1 | 1tw4B-1inpA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nq7 | NUCLEAR RECEPTORROR-BETA (Rattusnorvegicus) |
PF00104(Hormone_recep) | 5 | TYR A 389ILE A 413HIS A 400ILE A 396LEU A 392 | None | 1.27A | 1tw4B-1nq7A:undetectable | 1tw4B-1nq7A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obh | LEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2)PF14795(Leucyl-specific) | 5 | TYR A 758LEU A 721LEU A 725LEU A 714ILE A 772 | None | 1.25A | 1tw4B-1obhA:undetectable | 1tw4B-1obhA:9.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1p6p | FATTY ACID-BINDINGPROTEIN, LIVER (Rhinellaarenarum) |
PF14651(Lipocalin_7) | 7 | TYR A 14LEU A 18THR A 53HIS A 98ILE A 111LEU A 118ARG A 120 | None | 0.84A | 1tw4B-1p6pA:19.3 | 1tw4B-1p6pA:66.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qb4 | PHOSPHOENOLPYRUVATECARBOXYLASE (Escherichiacoli) |
PF00311(PEPcase) | 5 | LEU A 490LEU A 489THR A 264ARG A 265ILE A 474 | None | 1.16A | 1tw4B-1qb4A:undetectable | 1tw4B-1qb4A:9.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcn | CTP SYNTHETASE (Thermusthermophilus) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | LEU A 517LEU A 388LEU A 459ILE A 450LEU A 394 | None | 1.20A | 1tw4B-1vcnA:0.0 | 1tw4B-1vcnA:12.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vk5 | EXPRESSED PROTEIN (Arabidopsisthaliana) |
PF09187(RdDM_RDM1) | 5 | LEU A 90LEU A 70LEU A 82ARG A 128ILE A 111 | None | 1.24A | 1tw4B-1vk5A:0.0 | 1tw4B-1vk5A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkl | HIGH-AFFINITYCAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 7A (Homo sapiens) |
PF00233(PDEase_I) | 5 | LEU A 194LEU A 189ILE A 201THR A 251HIS A 181 | None | 1.14A | 1tw4B-1zklA:0.0 | 1tw4B-1zklA:15.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zry | FATTY ACID-BINDINGPROTEIN, LIVER (Gallus gallus) |
PF14651(Lipocalin_7) | 6 | TYR A 14LEU A 23ILE A 34THR A 53LEU A 118ARG A 120 | None | 0.88A | 1tw4B-1zryA:12.4 | 1tw4B-1zryA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zvu | TOPOISOMERASE IVSUBUNIT A (Escherichiacoli) |
PF00521(DNA_topoisoIV)PF03989(DNA_gyraseA_C) | 5 | LEU A 343ILE A 228ARG A 225ILE A 180LEU A 329 | None | 1.20A | 1tw4B-1zvuA:undetectable | 1tw4B-1zvuA:11.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4a | BH3024 (Bacillushalodurans) |
PF00072(Response_reg) | 5 | LEU A 52LEU A 51ILE A 63ILE A 19LEU A 8 | None | 1.18A | 1tw4B-2b4aA:undetectable | 1tw4B-2b4aA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c11 | MEMBRANE COPPERAMINE OXIDASE (Homo sapiens) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 5 | LEU A 274LEU A 277LEU A 195ILE A 183THR A 210 | None | 1.22A | 1tw4B-2c11A:undetectable | 1tw4B-2c11A:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehh | DIHYDRODIPICOLINATESYNTHASE (Aquifexaeolicus) |
PF00701(DHDPS) | 5 | LEU A 100ILE A 134THR A 138ILE A 173ARG A 169 | None | 1.15A | 1tw4B-2ehhA:undetectable | 1tw4B-2ehhA:18.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ftb | FATTY ACID-BINDINGPROTEIN 2, LIVER (Ambystomamexicanum) |
PF14651(Lipocalin_7) | 7 | TYR A 14LEU A 18ILE A 34THR A 53HIS A 98LEU A 118ARG A 120 | NoneNoneNoneOLA A 130 ( 4.7A)OLA A 130 ( 4.8A)NoneNone | 0.69A | 1tw4B-2ftbA:22.3 | 1tw4B-2ftbA:73.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hhz | PYRIDOXAMINE5'-PHOSPHATEOXIDASE-RELATED (Streptococcussuis) |
PF01243(Putative_PNPOx) | 5 | LEU A 56ILE A 118HIS A 103ILE A 104LEU A 91 | None | 1.09A | 1tw4B-2hhzA:1.9 | 1tw4B-2hhzA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hzg | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME/ENOLASESUPERFAMILY (Rhodobactersphaeroides) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 218LEU A 215ILE A 171HIS A 238ILE A 250 | None | 0.92A | 1tw4B-2hzgA:undetectable | 1tw4B-2hzgA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iyf | OLEANDOMYCINGLYCOSYLTRANSFERASE (Streptomycesantibioticus) |
PF00201(UDPGT) | 5 | LEU A 264LEU A 280ILE A 268ILE A 295LEU A 235 | None | 1.21A | 1tw4B-2iyfA:undetectable | 1tw4B-2iyfA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lci | PROTEIN OR36 (syntheticconstruct) |
no annotation | 5 | TYR A 76LEU A 74LEU A 70ILE A 56LEU A 4 | None | 1.11A | 1tw4B-2lciA:undetectable | 1tw4B-2lciA:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lnh | NEURALWISKOTT-ALDRICHSYNDROME PROTEIN (Homo sapiens) |
PF00786(PBD) | 5 | LEU A 27LEU A 30ILE A 50HIS A 6ILE A 7 | None | 1.09A | 1tw4B-2lnhA:undetectable | 1tw4B-2lnhA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pi5 | DNA-DIRECTED RNAPOLYMERASE (Escherichiavirus T7) |
PF00940(RNA_pol)PF14700(RPOL_N) | 5 | LEU A 757LEU A 749ILE A 244THR A 122ILE A 761 | None | 0.91A | 1tw4B-2pi5A:undetectable | 1tw4B-2pi5A:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po3 | 4-DEHYDRASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 5 | TYR A1273LEU A1359ILE A1367ARG A1025LEU A1277 | None | 1.19A | 1tw4B-2po3A:undetectable | 1tw4B-2po3A:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qm3 | PREDICTEDMETHYLTRANSFERASE (Pyrococcusfuriosus) |
PF01861(DUF43) | 5 | LEU A 106LEU A 170ILE A 152THR A 220MET A 141 | None | 1.25A | 1tw4B-2qm3A:undetectable | 1tw4B-2qm3A:15.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qo4 | LIVER-BASIC FATTYACID BINDING PROTEIN (Danio rerio) |
PF14651(Lipocalin_7) | 5 | TYR A 14LEU A 18MET A 73HIS A 98ARG A 120 | NoneCHD A 130 ( 4.7A)NoneIPA A 140 (-3.7A)CHD A 130 (-3.4A) | 0.98A | 1tw4B-2qo4A:21.5 | 1tw4B-2qo4A:69.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qo4 | LIVER-BASIC FATTYACID BINDING PROTEIN (Danio rerio) |
PF14651(Lipocalin_7) | 5 | TYR A 14LEU A 18THR A 53MET A 73ARG A 120 | NoneCHD A 130 ( 4.7A)CHD A 130 ( 4.1A)NoneCHD A 130 (-3.4A) | 0.91A | 1tw4B-2qo4A:21.5 | 1tw4B-2qo4A:69.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6j | RNA HELICASE (Kokobera virus) |
PF00271(Helicase_C)PF07652(Flavi_DEAD) | 5 | LEU A 308LEU A 307LEU A 85ILE A 116ARG A 113 | None | 1.19A | 1tw4B-2v6jA:undetectable | 1tw4B-2v6jA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9k | UNCHARACTERIZEDPROTEIN FLJ32312 (Homo sapiens) |
no annotation | 5 | TYR A 414LEU A 476HIS A 491ILE A 511LEU A 514 | EPE A1534 ( 4.9A)NoneNoneNoneNone | 1.25A | 1tw4B-2v9kA:undetectable | 1tw4B-2v9kA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsm | HYDROGENASEEXPRESSION/FORMATIONPROTEIN (HYPB) (Archaeoglobusfulgidus) |
PF02492(cobW) | 5 | LEU A 112LEU A 111LEU A 25ILE A 99ILE A 47 | None | 1.25A | 1tw4B-2wsmA:undetectable | 1tw4B-2wsmA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtb | FATTY ACIDMULTIFUNCTIONALPROTEIN (ATMFP2) (Arabidopsisthaliana) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | TYR A 43LEU A 39LEU A 36LEU A 23LEU A 97 | None | 1.22A | 1tw4B-2wtbA:undetectable | 1tw4B-2wtbA:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww8 | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF13519(VWA_2) | 5 | ILE A 259THR A 255ARG A 256ILE A 369LEU A 324 | None | 1.11A | 1tw4B-2ww8A:undetectable | 1tw4B-2ww8A:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | TYR A 306LEU A 401ILE A 412THR A 409ILE A 279 | None | 1.08A | 1tw4B-2xaxA:undetectable | 1tw4B-2xaxA:12.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xka | FTSZ/TUBULIN-RELATEDPROTEIN (Bacillusthuringiensis) |
PF00091(Tubulin) | 5 | LEU A 304ILE A 283THR A 247ILE A 343LEU A 347 | None | 1.19A | 1tw4B-2xkaA:undetectable | 1tw4B-2xkaA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yva | DNAAINITIATOR-ASSOCIATING PROTEIN DIAA (Escherichiacoli) |
PF13580(SIS_2) | 5 | LEU A 113LEU A 34ILE A 161THR A 178ILE A 125 | None | 1.20A | 1tw4B-2yvaA:undetectable | 1tw4B-2yvaA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7o | MITOGEN-ACTIVATEDPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 298LEU A 302LEU A 274ILE A 279ILE A 214 | None | 1.21A | 1tw4B-3e7oA:undetectable | 1tw4B-3e7oA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grz | RIBOSOMAL PROTEINL11METHYLTRANSFERASE (Lactobacillusdelbrueckii) |
PF06325(PrmA) | 5 | LEU A 244LEU A 178LEU A 265ILE A 309ARG A 172 | None | 1.16A | 1tw4B-3grzA:undetectable | 1tw4B-3grzA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvp | ADENOSYLHOMOCYSTEINASE 3 (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 547LEU A 550ILE A 307THR A 315LEU A 242 | None | 1.26A | 1tw4B-3gvpA:undetectable | 1tw4B-3gvpA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 5 | LEU A 258ILE A 265THR A 94ILE A 14LEU A 10 | ATP A 301 (-3.8A)NoneNoneNoneNone | 1.14A | 1tw4B-3h1qA:undetectable | 1tw4B-3h1qA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7f | SERINEHYDROXYMETHYLTRANSFERASE 1 (Mycobacteriumtuberculosis) |
PF00464(SHMT) | 5 | LEU A 336LEU A 337LEU A 328ILE A 385LEU A 401 | None | 1.16A | 1tw4B-3h7fA:undetectable | 1tw4B-3h7fA:13.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hiq | VACUOLAR SAPORIN (Saponariaofficinalis) |
PF00161(RIP) | 5 | TYR A 16LEU A 20LEU A 23ILE A 181LEU A 6 | None | 1.25A | 1tw4B-3hiqA:undetectable | 1tw4B-3hiqA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hiw | VACUOLAR SAPORIN (Saponariaofficinalis) |
PF00161(RIP) | 5 | TYR A 16LEU A 20LEU A 23ILE A 181LEU A 6 | None | 1.23A | 1tw4B-3hiwA:undetectable | 1tw4B-3hiwA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krs | TRIOSEPHOSPHATEISOMERASE (Cryptosporidiumparvum) |
PF00121(TIM) | 5 | LEU A 153LEU A 149ILE A 125HIS A 187ILE A 208 | None | 1.20A | 1tw4B-3krsA:undetectable | 1tw4B-3krsA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mg3 | ORANGECAROTENOID-BINDINGPROTEIN (Synechocystissp. PCC 6803) |
PF02136(NTF2)PF09150(Carot_N) | 5 | TYR A 201LEU A 205LEU A 248ILE A 303ILE A 214 | ECH A 351 (-4.5A)ECH A 351 (-4.6A)ECH A 351 ( 3.8A)ECH A 351 (-2.7A)None | 1.00A | 1tw4B-3mg3A:1.1 | 1tw4B-3mg3A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqt | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 190LEU A 193LEU A 229ILE A 152LEU A 149 | None | 1.23A | 1tw4B-3mqtA:undetectable | 1tw4B-3mqtA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqz | UNCHARACTERIZEDCONSERVED PROTEINDUF1054 (Leptospirillumrubarum) |
PF06335(DUF1054) | 5 | LEU A 9LEU A 191ILE A 100THR A 79ILE A 198 | None | 1.20A | 1tw4B-3mqzA:undetectable | 1tw4B-3mqzA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o9p | PERIPLASMIC MUREINPEPTIDE-BINDINGPROTEIN (Escherichiacoli) |
PF00496(SBP_bac_5) | 5 | TYR A 273LEU A 361LEU A 362ILE A 372ILE A 436 | None | 0.99A | 1tw4B-3o9pA:undetectable | 1tw4B-3o9pA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on7 | OXIDOREDUCTASE,IRON/ASCORBATEFAMILY (Shewanellaoneidensis) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | LEU A 119LEU A 120ILE A 209ILE A 213LEU A 21 | None | 1.01A | 1tw4B-3on7A:undetectable | 1tw4B-3on7A:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oos | ALPHA/BETA HYDROLASEFAMILY PROTEIN (Bacillusanthracis) |
PF00561(Abhydrolase_1) | 5 | LEU A 167ILE A 147ARG A 146LEU A 199ARG A 203 | GOL A 279 ( 4.6A)NoneGOL A 279 (-3.4A)NonePG4 A 281 (-4.2A) | 1.09A | 1tw4B-3oosA:undetectable | 1tw4B-3oosA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfo | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
PF12850(Metallophos_2) | 5 | TYR A 34LEU A 57LEU A 53ILE A 185LEU A 9 | None | 1.13A | 1tw4B-3qfoA:undetectable | 1tw4B-3qfoA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | LEU A 379LEU A 403ILE A 373THR A 334ILE A 399 | None | 1.24A | 1tw4B-3rmtA:undetectable | 1tw4B-3rmtA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s51 | FANCONI ANEMIA GROUPI PROTEIN HOMOLOG (Mus musculus) |
PF14674(FANCI_S1-cap)PF14675(FANCI_S1)PF14676(FANCI_S2)PF14677(FANCI_S3)PF14678(FANCI_S4)PF14679(FANCI_HD1)PF14680(FANCI_HD2) | 5 | LEU A 108LEU A 105ILE A 68ILE A 132LEU A 129 | None | 0.93A | 1tw4B-3s51A:undetectable | 1tw4B-3s51A:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgg | HYPOTHETICALHYDROLASE (Bacteroidesthetaiotaomicron) |
PF14323(GxGYxYP_C)PF16216(GxGYxYP_N) | 5 | TYR A 137LEU A 133LEU A 130THR A 297ILE A 173 | None | 1.06A | 1tw4B-3sggA:undetectable | 1tw4B-3sggA:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6a | BREAST CANCERANTI-ESTROGENRESISTANCE PROTEIN 3 (Homo sapiens) |
PF00617(RasGEF) | 5 | LEU A 811LEU A 815ILE A 613THR A 626LEU A 532 | None | 1.13A | 1tw4B-3t6aA:undetectable | 1tw4B-3t6aA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufb | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLTRANSFERASESUBUNIT (Vibriovulnificus) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | LEU A 121ILE A 164ILE A 96LEU A 101ARG A 158 | None | 1.17A | 1tw4B-3ufbA:undetectable | 1tw4B-3ufbA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu9 | CHROMOSOMESEGREGATION INMEIOSIS PROTEIN 2 (Saccharomycescerevisiae) |
PF16834(CSM2) | 5 | TYR B 115LEU B 20THR B 43ILE B 69LEU B 37 | None | 1.08A | 1tw4B-3vu9B:undetectable | 1tw4B-3vu9B:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6j | SCPA (Geobacillusstearothermophilus) |
PF02616(SMC_ScpA) | 5 | LEU A 21LEU A 24ILE A 72HIS A 49ILE A 48 | None | 1.13A | 1tw4B-3w6jA:undetectable | 1tw4B-3w6jA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zhe | PROTEIN SMG-7 (Caenorhabditiselegans) |
PF10373(EST1_DNA_bind) | 5 | TYR B 292LEU B 296LEU B 299ILE B 387ILE B 318 | None | 1.09A | 1tw4B-3zheB:undetectable | 1tw4B-3zheB:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c89 | ESTERASE (Lactobacillusplantarum) |
PF07859(Abhydrolase_3) | 5 | TYR A 234LEU A 38LEU A 35ILE A 223LEU A 231 | None | 1.23A | 1tw4B-4c89A:undetectable | 1tw4B-4c89A:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cr4 | 26S PROTEASEREGULATORY SUBUNIT 8HOMOLOG (Saccharomycescerevisiae) |
PF00004(AAA) | 5 | LEU J 300LEU J 297THR J 256ILE J 310LEU J 304 | None | 1.17A | 1tw4B-4cr4J:undetectable | 1tw4B-4cr4J:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4j | ARGININE DEIMINASE (Mycoplasmapenetrans) |
PF02274(Amidinotransf) | 5 | LEU A 119LEU A 199ILE A 228ARG A 225MET A 174 | None | 1.19A | 1tw4B-4e4jA:undetectable | 1tw4B-4e4jA:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecj | GLUTATHIONES-TRANSFERASE (Pseudomonasaeruginosa) |
PF00043(GST_C)PF02798(GST_N) | 5 | LEU A 72LEU A 82ILE A 17ARG A 191ILE A 55 | None | 1.24A | 1tw4B-4ecjA:undetectable | 1tw4B-4ecjA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmz | INTERNALIN (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4)PF13855(LRR_8) | 5 | LEU A 184LEU A 161LEU A 190ILE A 155LEU A 178 | None | 1.22A | 1tw4B-4fmzA:undetectable | 1tw4B-4fmzA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ghk | GAMMA-GLUTAMYLPHOSPHATE REDUCTASE (Burkholderiathailandensis) |
PF00171(Aldedh) | 5 | TYR A 282LEU A 278LEU A 275THR A 376LEU A 289 | None | 1.24A | 1tw4B-4ghkA:undetectable | 1tw4B-4ghkA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hes | BETA-LACTAMASE CLASSA-LIKE PROTEIN (Veillonellaparvula) |
PF13354(Beta-lactamase2) | 5 | LEU A 174LEU A 171ILE A 62THR A 122HIS A 216 | None | 1.22A | 1tw4B-4hesA:1.0 | 1tw4B-4hesA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifq | NUCLEOPORIN NUP192 (Saccharomycescerevisiae) |
PF11894(Nup192) | 5 | LEU A 32LEU A 29LEU A 11ILE A 135LEU A 140 | None | 1.10A | 1tw4B-4ifqA:undetectable | 1tw4B-4ifqA:8.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikh | GLUTATHIONES-TRANSFERASE (Pseudomonasprotegens) |
PF00043(GST_C)PF02798(GST_N) | 5 | LEU A 94LEU A 104ILE A 36ARG A 221ILE A 74 | None | 1.24A | 1tw4B-4ikhA:undetectable | 1tw4B-4ikhA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nax | GLUTATHIONES-TRANSFERASE,N-TERMINAL DOMAINPROTEIN (Pseudomonasputida) |
PF00043(GST_C)PF02798(GST_N) | 5 | LEU A 94LEU A 104ILE A 36ARG A 220ILE A 74 | None | 1.26A | 1tw4B-4naxA:undetectable | 1tw4B-4naxA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nuz | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F2 (Streptococcuspyogenes) |
no annotation | 5 | LEU A 586LEU A 562LEU A 568ILE A 610ILE A 510 | None | 1.24A | 1tw4B-4nuzA:undetectable | 1tw4B-4nuzA:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5m | ISOVALERYL-COADEHYDROGENASE (Brucella suis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | LEU A 85LEU A 93ILE A 157ILE A 361LEU A 358 | None | 1.24A | 1tw4B-4o5mA:undetectable | 1tw4B-4o5mA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4opm | LIPASE (Acinetobacterbaumannii) |
PF12697(Abhydrolase_6) | 5 | LEU A 238LEU A 187LEU A 234ILE A 149ILE A 272 | 15P A 401 ( 4.9A)15P A 401 ( 4.6A)NoneNoneNone | 1.23A | 1tw4B-4opmA:undetectable | 1tw4B-4opmA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxp | RIBONUCLEASE E (Caulobactervibrioides) |
PF10150(RNase_E_G) | 5 | LEU A 179LEU A 186LEU A 177ILE A 265THR A 256 | None | 1.14A | 1tw4B-4oxpA:undetectable | 1tw4B-4oxpA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q62 | LEUCINE-RICHREPEAT-AND COILEDCOIL-CONTAININGPROTEIN (Legionellapneumophila) |
PF13855(LRR_8) | 5 | LEU A 83LEU A 80LEU A 52ILE A 62LEU A 106 | None | 1.28A | 1tw4B-4q62A:undetectable | 1tw4B-4q62A:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgq | GLYCEROL-1-PHOSPHATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF13685(Fe-ADH_2) | 5 | TYR A 239LEU A 235LEU A 232ILE A 243LEU A 241 | None | 1.14A | 1tw4B-4rgqA:undetectable | 1tw4B-4rgqA:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlz | CAPSID PROTEIN (Norwalk virus) |
PF00915(Calici_coat)PF08435(Calici_coat_C) | 5 | LEU A 524ILE A 483ARG A 481ILE A 494LEU A 429 | None | 1.23A | 1tw4B-4rlzA:undetectable | 1tw4B-4rlzA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u09 | LIC12759 (Leptospirainterrogans) |
PF13855(LRR_8) | 5 | LEU A 296LEU A 322ILE A 306ILE A 267LEU A 268 | None | 1.19A | 1tw4B-4u09A:undetectable | 1tw4B-4u09A:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uy6 | HISTIDINE-SPECIFICMETHYLTRANSFERASEEGTD (Mycolicibacteriumsmegmatis) |
PF10017(Methyltransf_33) | 5 | LEU A 183LEU A 296ILE A 164ILE A 149LEU A 146 | None | 1.03A | 1tw4B-4uy6A:undetectable | 1tw4B-4uy6A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzz | PUTATIVE SUGAR ABCTRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Lachnoclostridiumphytofermentans) |
PF13407(Peripla_BP_4) | 5 | TYR A 335LEU A 301LEU A 298ILE A 348ILE A 314 | None | 1.24A | 1tw4B-4wzzA:undetectable | 1tw4B-4wzzA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x4w | CCA TRNANUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL (Homo sapiens) |
PF01743(PolyA_pol)PF12627(PolyA_pol_RNAbd) | 5 | LEU A 89LEU A 25THR A 56MET A 63ILE A 75 | None | 1.00A | 1tw4B-4x4wA:undetectable | 1tw4B-4x4wA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgt | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 5 | LEU A1064LEU A1057ILE A 983THR A 985ILE A 973 | None | 1.22A | 1tw4B-4xgtA:undetectable | 1tw4B-4xgtA:9.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zaj | ARGININE--TRNALIGASE, CYTOPLASMIC (Homo sapiens) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 5 | LEU A 502ILE A 469ARG A 468ILE A 492LEU A 103 | None | 1.23A | 1tw4B-4zajA:undetectable | 1tw4B-4zajA:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7v | PUTATIVE GLYCOSIDASEPH117-RELATED (Bacteroidesthetaiotaomicron) |
PF04041(Glyco_hydro_130) | 5 | LEU B 254LEU B 282THR B 156MET B 223LEU B 251 | None | 1.19A | 1tw4B-5a7vB:undetectable | 1tw4B-5a7vB:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btb | AFR263CP (Eremotheciumgossypii) |
PF08652(RAI1) | 5 | LEU A 264LEU A 260ILE A 309ILE A 102LEU A 210 | None | 1.10A | 1tw4B-5btbA:undetectable | 1tw4B-5btbA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cgz | 4-OXALMESACONATEHYDRATASE (Pseudomonasputida) |
PF02585(PIG-L) | 5 | TYR A 106LEU A 99LEU A 41MET A 131ILE A 139 | None | 1.26A | 1tw4B-5cgzA:undetectable | 1tw4B-5cgzA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cjp | RASGTPASE-ACTIVATING-LIKE PROTEIN IQGAP2 (Homo sapiens) |
PF00616(RasGAP) | 5 | LEU E 984LEU E 981LEU E1069ILE E1063ILE E1113 | None | 1.13A | 1tw4B-5cjpE:undetectable | 1tw4B-5cjpE:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d1p | ATP-DEPENDENT RNALIGASE (Methanothermobacterthermautotrophicus) |
PF09414(RNA_ligase) | 5 | LEU A 177LEU A 194LEU A 200ILE A 105THR A 113 | None | 1.23A | 1tw4B-5d1pA:undetectable | 1tw4B-5d1pA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dn8 | GTPASE DER (Coxiellaburnetii) |
PF01926(MMR_HSR1)PF14714(KH_dom-like) | 5 | LEU A 116LEU A 107THR A 57ILE A 144LEU A 155 | None | 0.95A | 1tw4B-5dn8A:undetectable | 1tw4B-5dn8A:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dq6 | TUMOR NECROSISFACTOR ALPHA-INDUCEDPROTEIN 3 (Mus musculus) |
PF02338(OTU) | 5 | LEU A 122LEU A 126LEU A 104ILE A 248ILE A 37 | None | 1.18A | 1tw4B-5dq6A:undetectable | 1tw4B-5dq6A:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eor | ANTI VACCINIA VIRUSA27 ANTIBODY 8E3LIGHT CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | LEU L 78LEU L 21ILE L 63ILE L 83ARG L 66 | None | 1.12A | 1tw4B-5eorL:undetectable | 1tw4B-5eorL:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgr | ORANGE CAROTENOIDPROTEIN (OCP) (Nostoc sp. PCC7120) |
PF02136(NTF2)PF09150(Carot_N) | 5 | TYR A 203LEU A 207LEU A 250ILE A 305ILE A 216 | 45D A 501 (-4.6A)45D A 501 (-4.5A)45D A 501 ( 3.5A)45D A 501 (-2.8A)None | 1.00A | 1tw4B-5hgrA:2.1 | 1tw4B-5hgrA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l08 | CASPASE-8 (Homo sapiens) |
PF01335(DED) | 5 | LEU A 160LEU A 157ILE A 142ILE A 174LEU A 171 | None | 1.25A | 1tw4B-5l08A:undetectable | 1tw4B-5l08A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nxk | SERINE-RICH SECRETEDCELL WALL ANCHORED(LPXTG-MOTIF )PROTEIN (Lactobacillusreuteri) |
no annotation | 5 | LEU A 440LEU A 393ILE A 447ILE A 432LEU A 472 | None | 1.23A | 1tw4B-5nxkA:undetectable | 1tw4B-5nxkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ool | 39S RIBOSOMALPROTEIN L37,MITOCHONDRIAL (Homo sapiens) |
PF07147(PDCD9) | 5 | LEU 5 113ILE 5 314THR 5 126ILE 5 262LEU 5 265 | None | 1.03A | 1tw4B-5ool5:undetectable | 1tw4B-5ool5:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5svd | NUCLEOLAR PROTEIN 9 (Saccharomycescerevisiae) |
PF00806(PUF) | 5 | LEU A 461LEU A 472ILE A 518ILE A 506LEU A 510 | LEU A 461 ( 0.6A)LEU A 472 ( 0.5A)ILE A 518 ( 0.7A)ILE A 506 ( 0.7A)LEU A 510 ( 0.6A) | 1.22A | 1tw4B-5svdA:undetectable | 1tw4B-5svdA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t81 | EPOB (Sorangiumcellulosum) |
PF00668(Condensation) | 5 | TYR A 482LEU A 448ILE A 315HIS A 287LEU A 479 | None | 1.26A | 1tw4B-5t81A:undetectable | 1tw4B-5t81A:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrc | BIFUNCTIONALCOENZYME PQQSYNTHESIS PROTEINC/D (Methylobacteriumextorquens) |
no annotation | 5 | TYR A 64ILE A 68ARG A 91HIS A 41ARG A 61 | None | 1.22A | 1tw4B-5vrcA:undetectable | 1tw4B-5vrcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x4b | GTPASE DER (Bacillussubtilis) |
PF01926(MMR_HSR1) | 5 | LEU A 116LEU A 107THR A 58ILE A 144LEU A 155 | None | 0.94A | 1tw4B-5x4bA:undetectable | 1tw4B-5x4bA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyn | PLATINUM SENSITIVITYPROTEIN 3 (Saccharomycescerevisiae) |
no annotation | 5 | TYR A 215LEU A 141LEU A 107ILE A 175LEU A 211 | None | 1.22A | 1tw4B-5xynA:undetectable | 1tw4B-5xynA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyn | PLATINUM SENSITIVITYPROTEIN 3 (Saccharomycescerevisiae) |
no annotation | 5 | TYR A 215LEU A 160LEU A 107ILE A 175LEU A 211 | None | 1.13A | 1tw4B-5xynA:undetectable | 1tw4B-5xynA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3r | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 5 | LEU A2358LEU A2354LEU A2405ILE A2296ILE A2315 | None | 1.28A | 1tw4B-6b3rA:undetectable | 1tw4B-6b3rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en3 | ENDO-BETA-N-ACETYLGLUCOSAMINIDASEF2,MULTIFUNCTIONAL-AUTOPROCESSINGREPEATS-IN-TOXIN (Vibriocholerae;Streptococcuspyogenes) |
no annotation | 5 | LEU A 586LEU A 562LEU A 568ILE A 610ILE A 510 | None | 1.26A | 1tw4B-6en3A:undetectable | 1tw4B-6en3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Mus musculus) |
no annotation | 5 | TYR M 95LEU M 99LEU M 102ILE M 225ILE M 131 | None | 1.16A | 1tw4B-6g2jM:undetectable | 1tw4B-6g2jM:undetectable |