SIMILAR PATTERNS OF AMINO ACIDS FOR 1TW4_B_CHDB1130

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqo URE2 PROTEIN

(Saccharomyces
cerevisiae)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A 185
LEU A 201
ILE A 130
ARG A 344
LEU A 168
None
1.27A 1tw4B-1hqoA:
0.0
1tw4B-1hqoA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE


(Bos taurus)
PF00459
(Inositol_P)
5 TYR A 220
LEU A 296
LEU A 302
THR A 239
ILE A 230
None
1.28A 1tw4B-1inpA:
0.1
1tw4B-1inpA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq7 NUCLEAR RECEPTOR
ROR-BETA


(Rattus
norvegicus)
PF00104
(Hormone_recep)
5 TYR A 389
ILE A 413
HIS A 400
ILE A 396
LEU A 392
None
1.27A 1tw4B-1nq7A:
undetectable
1tw4B-1nq7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific)
5 TYR A 758
LEU A 721
LEU A 725
LEU A 714
ILE A 772
None
1.25A 1tw4B-1obhA:
undetectable
1tw4B-1obhA:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER


(Rhinella
arenarum)
PF14651
(Lipocalin_7)
7 TYR A  14
LEU A  18
THR A  53
HIS A  98
ILE A 111
LEU A 118
ARG A 120
None
0.84A 1tw4B-1p6pA:
19.3
1tw4B-1p6pA:
66.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Escherichia
coli)
PF00311
(PEPcase)
5 LEU A 490
LEU A 489
THR A 264
ARG A 265
ILE A 474
None
1.16A 1tw4B-1qb4A:
undetectable
1tw4B-1qb4A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 LEU A 517
LEU A 388
LEU A 459
ILE A 450
LEU A 394
None
1.20A 1tw4B-1vcnA:
0.0
1tw4B-1vcnA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk5 EXPRESSED PROTEIN

(Arabidopsis
thaliana)
PF09187
(RdDM_RDM1)
5 LEU A  90
LEU A  70
LEU A  82
ARG A 128
ILE A 111
None
1.24A 1tw4B-1vk5A:
0.0
1tw4B-1vk5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
5 LEU A 194
LEU A 189
ILE A 201
THR A 251
HIS A 181
None
1.14A 1tw4B-1zklA:
0.0
1tw4B-1zklA:
15.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER


(Gallus gallus)
PF14651
(Lipocalin_7)
6 TYR A  14
LEU A  23
ILE A  34
THR A  53
LEU A 118
ARG A 120
None
0.88A 1tw4B-1zryA:
12.4
1tw4B-1zryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A


(Escherichia
coli)
PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C)
5 LEU A 343
ILE A 228
ARG A 225
ILE A 180
LEU A 329
None
1.20A 1tw4B-1zvuA:
undetectable
1tw4B-1zvuA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4a BH3024

(Bacillus
halodurans)
PF00072
(Response_reg)
5 LEU A  52
LEU A  51
ILE A  63
ILE A  19
LEU A   8
None
1.18A 1tw4B-2b4aA:
undetectable
1tw4B-2b4aA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE


(Homo sapiens)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
5 LEU A 274
LEU A 277
LEU A 195
ILE A 183
THR A 210
None
1.22A 1tw4B-2c11A:
undetectable
1tw4B-2c11A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE


(Aquifex
aeolicus)
PF00701
(DHDPS)
5 LEU A 100
ILE A 134
THR A 138
ILE A 173
ARG A 169
None
1.15A 1tw4B-2ehhA:
undetectable
1tw4B-2ehhA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER


(Ambystoma
mexicanum)
PF14651
(Lipocalin_7)
7 TYR A  14
LEU A  18
ILE A  34
THR A  53
HIS A  98
LEU A 118
ARG A 120
None
None
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
None
0.69A 1tw4B-2ftbA:
22.3
1tw4B-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED


(Streptococcus
suis)
PF01243
(Putative_PNPOx)
5 LEU A  56
ILE A 118
HIS A 103
ILE A 104
LEU A  91
None
1.09A 1tw4B-2hhzA:
1.9
1tw4B-2hhzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY


(Rhodobacter
sphaeroides)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 218
LEU A 215
ILE A 171
HIS A 238
ILE A 250
None
0.92A 1tw4B-2hzgA:
undetectable
1tw4B-2hzgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE


(Streptomyces
antibioticus)
PF00201
(UDPGT)
5 LEU A 264
LEU A 280
ILE A 268
ILE A 295
LEU A 235
None
1.21A 1tw4B-2iyfA:
undetectable
1tw4B-2iyfA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lci PROTEIN OR36

(synthetic
construct)
no annotation 5 TYR A  76
LEU A  74
LEU A  70
ILE A  56
LEU A   4
None
1.11A 1tw4B-2lciA:
undetectable
1tw4B-2lciA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnh NEURAL
WISKOTT-ALDRICH
SYNDROME PROTEIN


(Homo sapiens)
PF00786
(PBD)
5 LEU A  27
LEU A  30
ILE A  50
HIS A   6
ILE A   7
None
1.09A 1tw4B-2lnhA:
undetectable
1tw4B-2lnhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE


(Escherichia
virus T7)
PF00940
(RNA_pol)
PF14700
(RPOL_N)
5 LEU A 757
LEU A 749
ILE A 244
THR A 122
ILE A 761
None
0.91A 1tw4B-2pi5A:
undetectable
1tw4B-2pi5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 TYR A1273
LEU A1359
ILE A1367
ARG A1025
LEU A1277
None
1.19A 1tw4B-2po3A:
undetectable
1tw4B-2po3A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE


(Pyrococcus
furiosus)
PF01861
(DUF43)
5 LEU A 106
LEU A 170
ILE A 152
THR A 220
MET A 141
None
1.25A 1tw4B-2qm3A:
undetectable
1tw4B-2qm3A:
15.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN


(Danio rerio)
PF14651
(Lipocalin_7)
5 TYR A  14
LEU A  18
MET A  73
HIS A  98
ARG A 120
None
CHD  A 130 ( 4.7A)
None
IPA  A 140 (-3.7A)
CHD  A 130 (-3.4A)
0.98A 1tw4B-2qo4A:
21.5
1tw4B-2qo4A:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN


(Danio rerio)
PF14651
(Lipocalin_7)
5 TYR A  14
LEU A  18
THR A  53
MET A  73
ARG A 120
None
CHD  A 130 ( 4.7A)
CHD  A 130 ( 4.1A)
None
CHD  A 130 (-3.4A)
0.91A 1tw4B-2qo4A:
21.5
1tw4B-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus)
PF00271
(Helicase_C)
PF07652
(Flavi_DEAD)
5 LEU A 308
LEU A 307
LEU A  85
ILE A 116
ARG A 113
None
1.19A 1tw4B-2v6jA:
undetectable
1tw4B-2v6jA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312


(Homo sapiens)
no annotation 5 TYR A 414
LEU A 476
HIS A 491
ILE A 511
LEU A 514
EPE  A1534 ( 4.9A)
None
None
None
None
1.25A 1tw4B-2v9kA:
undetectable
1tw4B-2v9kA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)


(Archaeoglobus
fulgidus)
PF02492
(cobW)
5 LEU A 112
LEU A 111
LEU A  25
ILE A  99
ILE A  47
None
1.25A 1tw4B-2wsmA:
undetectable
1tw4B-2wsmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)


(Arabidopsis
thaliana)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 TYR A  43
LEU A  39
LEU A  36
LEU A  23
LEU A  97
None
1.22A 1tw4B-2wtbA:
undetectable
1tw4B-2wtbA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF13519
(VWA_2)
5 ILE A 259
THR A 255
ARG A 256
ILE A 369
LEU A 324
None
1.11A 1tw4B-2ww8A:
undetectable
1tw4B-2ww8A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 TYR A 306
LEU A 401
ILE A 412
THR A 409
ILE A 279
None
1.08A 1tw4B-2xaxA:
undetectable
1tw4B-2xaxA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN


(Bacillus
thuringiensis)
PF00091
(Tubulin)
5 LEU A 304
ILE A 283
THR A 247
ILE A 343
LEU A 347
None
1.19A 1tw4B-2xkaA:
undetectable
1tw4B-2xkaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA


(Escherichia
coli)
PF13580
(SIS_2)
5 LEU A 113
LEU A  34
ILE A 161
THR A 178
ILE A 125
None
1.20A 1tw4B-2yvaA:
undetectable
1tw4B-2yvaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A 298
LEU A 302
LEU A 274
ILE A 279
ILE A 214
None
1.21A 1tw4B-3e7oA:
undetectable
1tw4B-3e7oA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE


(Lactobacillus
delbrueckii)
PF06325
(PrmA)
5 LEU A 244
LEU A 178
LEU A 265
ILE A 309
ARG A 172
None
1.16A 1tw4B-3grzA:
undetectable
1tw4B-3grzA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3


(Homo sapiens)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A 547
LEU A 550
ILE A 307
THR A 315
LEU A 242
None
1.26A 1tw4B-3gvpA:
undetectable
1tw4B-3gvpA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
5 LEU A 258
ILE A 265
THR A  94
ILE A  14
LEU A  10
ATP  A 301 (-3.8A)
None
None
None
None
1.14A 1tw4B-3h1qA:
undetectable
1tw4B-3h1qA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1


(Mycobacterium
tuberculosis)
PF00464
(SHMT)
5 LEU A 336
LEU A 337
LEU A 328
ILE A 385
LEU A 401
None
1.16A 1tw4B-3h7fA:
undetectable
1tw4B-3h7fA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis)
PF00161
(RIP)
5 TYR A  16
LEU A  20
LEU A  23
ILE A 181
LEU A   6
None
1.25A 1tw4B-3hiqA:
undetectable
1tw4B-3hiqA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis)
PF00161
(RIP)
5 TYR A  16
LEU A  20
LEU A  23
ILE A 181
LEU A   6
None
1.23A 1tw4B-3hiwA:
undetectable
1tw4B-3hiwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE


(Cryptosporidium
parvum)
PF00121
(TIM)
5 LEU A 153
LEU A 149
ILE A 125
HIS A 187
ILE A 208
None
1.20A 1tw4B-3krsA:
undetectable
1tw4B-3krsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg3 ORANGE
CAROTENOID-BINDING
PROTEIN


(Synechocystis
sp. PCC 6803)
PF02136
(NTF2)
PF09150
(Carot_N)
5 TYR A 201
LEU A 205
LEU A 248
ILE A 303
ILE A 214
ECH  A 351 (-4.5A)
ECH  A 351 (-4.6A)
ECH  A 351 ( 3.8A)
ECH  A 351 (-2.7A)
None
1.00A 1tw4B-3mg3A:
1.1
1tw4B-3mg3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Shewanella
pealeana)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 190
LEU A 193
LEU A 229
ILE A 152
LEU A 149
None
1.23A 1tw4B-3mqtA:
undetectable
1tw4B-3mqtA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqz UNCHARACTERIZED
CONSERVED PROTEIN
DUF1054


(Leptospirillum
rubarum)
PF06335
(DUF1054)
5 LEU A   9
LEU A 191
ILE A 100
THR A  79
ILE A 198
None
1.20A 1tw4B-3mqzA:
undetectable
1tw4B-3mqzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN


(Escherichia
coli)
PF00496
(SBP_bac_5)
5 TYR A 273
LEU A 361
LEU A 362
ILE A 372
ILE A 436
None
0.99A 1tw4B-3o9pA:
undetectable
1tw4B-3o9pA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY


(Shewanella
oneidensis)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
5 LEU A 119
LEU A 120
ILE A 209
ILE A 213
LEU A  21
None
1.01A 1tw4B-3on7A:
undetectable
1tw4B-3on7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN


(Bacillus
anthracis)
PF00561
(Abhydrolase_1)
5 LEU A 167
ILE A 147
ARG A 146
LEU A 199
ARG A 203
GOL  A 279 ( 4.6A)
None
GOL  A 279 (-3.4A)
None
PG4  A 281 (-4.2A)
1.09A 1tw4B-3oosA:
undetectable
1tw4B-3oosA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF12850
(Metallophos_2)
5 TYR A  34
LEU A  57
LEU A  53
ILE A 185
LEU A   9
None
1.13A 1tw4B-3qfoA:
undetectable
1tw4B-3qfoA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
halodurans)
PF00275
(EPSP_synthase)
5 LEU A 379
LEU A 403
ILE A 373
THR A 334
ILE A 399
None
1.24A 1tw4B-3rmtA:
undetectable
1tw4B-3rmtA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG


(Mus musculus)
PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2)
5 LEU A 108
LEU A 105
ILE A  68
ILE A 132
LEU A 129
None
0.93A 1tw4B-3s51A:
undetectable
1tw4B-3s51A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N)
5 TYR A 137
LEU A 133
LEU A 130
THR A 297
ILE A 173
None
1.06A 1tw4B-3sggA:
undetectable
1tw4B-3sggA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3


(Homo sapiens)
PF00617
(RasGEF)
5 LEU A 811
LEU A 815
ILE A 613
THR A 626
LEU A 532
None
1.13A 1tw4B-3t6aA:
undetectable
1tw4B-3t6aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT


(Vibrio
vulnificus)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
5 LEU A 121
ILE A 164
ILE A  96
LEU A 101
ARG A 158
None
1.17A 1tw4B-3ufbA:
undetectable
1tw4B-3ufbA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu9 CHROMOSOME
SEGREGATION IN
MEIOSIS PROTEIN 2


(Saccharomyces
cerevisiae)
PF16834
(CSM2)
5 TYR B 115
LEU B  20
THR B  43
ILE B  69
LEU B  37
None
1.08A 1tw4B-3vu9B:
undetectable
1tw4B-3vu9B:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6j SCPA

(Geobacillus
stearothermophilus)
PF02616
(SMC_ScpA)
5 LEU A  21
LEU A  24
ILE A  72
HIS A  49
ILE A  48
None
1.13A 1tw4B-3w6jA:
undetectable
1tw4B-3w6jA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans)
PF10373
(EST1_DNA_bind)
5 TYR B 292
LEU B 296
LEU B 299
ILE B 387
ILE B 318
None
1.09A 1tw4B-3zheB:
undetectable
1tw4B-3zheB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum)
PF07859
(Abhydrolase_3)
5 TYR A 234
LEU A  38
LEU A  35
ILE A 223
LEU A 231
None
1.23A 1tw4B-4c89A:
undetectable
1tw4B-4c89A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG


(Saccharomyces
cerevisiae)
PF00004
(AAA)
5 LEU J 300
LEU J 297
THR J 256
ILE J 310
LEU J 304
None
1.17A 1tw4B-4cr4J:
undetectable
1tw4B-4cr4J:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans)
PF02274
(Amidinotransf)
5 LEU A 119
LEU A 199
ILE A 228
ARG A 225
MET A 174
None
1.19A 1tw4B-4e4jA:
undetectable
1tw4B-4e4jA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecj GLUTATHIONE
S-TRANSFERASE


(Pseudomonas
aeruginosa)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A  72
LEU A  82
ILE A  17
ARG A 191
ILE A  55
None
1.24A 1tw4B-4ecjA:
undetectable
1tw4B-4ecjA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8)
5 LEU A 184
LEU A 161
LEU A 190
ILE A 155
LEU A 178
None
1.22A 1tw4B-4fmzA:
undetectable
1tw4B-4fmzA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Burkholderia
thailandensis)
PF00171
(Aldedh)
5 TYR A 282
LEU A 278
LEU A 275
THR A 376
LEU A 289
None
1.24A 1tw4B-4ghkA:
undetectable
1tw4B-4ghkA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN


(Veillonella
parvula)
PF13354
(Beta-lactamase2)
5 LEU A 174
LEU A 171
ILE A  62
THR A 122
HIS A 216
None
1.22A 1tw4B-4hesA:
1.0
1tw4B-4hesA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae)
PF11894
(Nup192)
5 LEU A  32
LEU A  29
LEU A  11
ILE A 135
LEU A 140
None
1.10A 1tw4B-4ifqA:
undetectable
1tw4B-4ifqA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikh GLUTATHIONE
S-TRANSFERASE


(Pseudomonas
protegens)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A  94
LEU A 104
ILE A  36
ARG A 221
ILE A  74
None
1.24A 1tw4B-4ikhA:
undetectable
1tw4B-4ikhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN


(Pseudomonas
putida)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A  94
LEU A 104
ILE A  36
ARG A 220
ILE A  74
None
1.26A 1tw4B-4naxA:
undetectable
1tw4B-4naxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2


(Streptococcus
pyogenes)
no annotation 5 LEU A 586
LEU A 562
LEU A 568
ILE A 610
ILE A 510
None
1.24A 1tw4B-4nuzA:
undetectable
1tw4B-4nuzA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE


(Brucella suis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 LEU A  85
LEU A  93
ILE A 157
ILE A 361
LEU A 358
None
1.24A 1tw4B-4o5mA:
undetectable
1tw4B-4o5mA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii)
PF12697
(Abhydrolase_6)
5 LEU A 238
LEU A 187
LEU A 234
ILE A 149
ILE A 272
15P  A 401 ( 4.9A)
15P  A 401 ( 4.6A)
None
None
None
1.23A 1tw4B-4opmA:
undetectable
1tw4B-4opmA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxp RIBONUCLEASE E

(Caulobacter
vibrioides)
PF10150
(RNase_E_G)
5 LEU A 179
LEU A 186
LEU A 177
ILE A 265
THR A 256
None
1.14A 1tw4B-4oxpA:
undetectable
1tw4B-4oxpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN


(Legionella
pneumophila)
PF13855
(LRR_8)
5 LEU A  83
LEU A  80
LEU A  52
ILE A  62
LEU A 106
None
1.28A 1tw4B-4q62A:
undetectable
1tw4B-4q62A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF13685
(Fe-ADH_2)
5 TYR A 239
LEU A 235
LEU A 232
ILE A 243
LEU A 241
None
1.14A 1tw4B-4rgqA:
undetectable
1tw4B-4rgqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlz CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
5 LEU A 524
ILE A 483
ARG A 481
ILE A 494
LEU A 429
None
1.23A 1tw4B-4rlzA:
undetectable
1tw4B-4rlzA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans)
PF13855
(LRR_8)
5 LEU A 296
LEU A 322
ILE A 306
ILE A 267
LEU A 268
None
1.19A 1tw4B-4u09A:
undetectable
1tw4B-4u09A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD


(Mycolicibacterium
smegmatis)
PF10017
(Methyltransf_33)
5 LEU A 183
LEU A 296
ILE A 164
ILE A 149
LEU A 146
None
1.03A 1tw4B-4uy6A:
undetectable
1tw4B-4uy6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN


(Lachnoclostridium
phytofermentans)
PF13407
(Peripla_BP_4)
5 TYR A 335
LEU A 301
LEU A 298
ILE A 348
ILE A 314
None
1.24A 1tw4B-4wzzA:
undetectable
1tw4B-4wzzA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
5 LEU A  89
LEU A  25
THR A  56
MET A  63
ILE A  75
None
1.00A 1tw4B-4x4wA:
undetectable
1tw4B-4x4wA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE


(Neurospora
crassa)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
5 LEU A1064
LEU A1057
ILE A 983
THR A 985
ILE A 973
None
1.22A 1tw4B-4xgtA:
undetectable
1tw4B-4xgtA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
5 LEU A 502
ILE A 469
ARG A 468
ILE A 492
LEU A 103
None
1.23A 1tw4B-4zajA:
undetectable
1tw4B-4zajA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED


(Bacteroides
thetaiotaomicron)
PF04041
(Glyco_hydro_130)
5 LEU B 254
LEU B 282
THR B 156
MET B 223
LEU B 251
None
1.19A 1tw4B-5a7vB:
undetectable
1tw4B-5a7vB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii)
PF08652
(RAI1)
5 LEU A 264
LEU A 260
ILE A 309
ILE A 102
LEU A 210
None
1.10A 1tw4B-5btbA:
undetectable
1tw4B-5btbA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE


(Pseudomonas
putida)
PF02585
(PIG-L)
5 TYR A 106
LEU A  99
LEU A  41
MET A 131
ILE A 139
None
1.26A 1tw4B-5cgzA:
undetectable
1tw4B-5cgzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2


(Homo sapiens)
PF00616
(RasGAP)
5 LEU E 984
LEU E 981
LEU E1069
ILE E1063
ILE E1113
None
1.13A 1tw4B-5cjpE:
undetectable
1tw4B-5cjpE:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE


(Methanothermobacter
thermautotrophicus)
PF09414
(RNA_ligase)
5 LEU A 177
LEU A 194
LEU A 200
ILE A 105
THR A 113
None
1.23A 1tw4B-5d1pA:
undetectable
1tw4B-5d1pA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn8 GTPASE DER

(Coxiella
burnetii)
PF01926
(MMR_HSR1)
PF14714
(KH_dom-like)
5 LEU A 116
LEU A 107
THR A  57
ILE A 144
LEU A 155
None
0.95A 1tw4B-5dn8A:
undetectable
1tw4B-5dn8A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3


(Mus musculus)
PF02338
(OTU)
5 LEU A 122
LEU A 126
LEU A 104
ILE A 248
ILE A  37
None
1.18A 1tw4B-5dq6A:
undetectable
1tw4B-5dq6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 LEU L  78
LEU L  21
ILE L  63
ILE L  83
ARG L  66
None
1.12A 1tw4B-5eorL:
undetectable
1tw4B-5eorL:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)


(Nostoc sp. PCC
7120)
PF02136
(NTF2)
PF09150
(Carot_N)
5 TYR A 203
LEU A 207
LEU A 250
ILE A 305
ILE A 216
45D  A 501 (-4.6A)
45D  A 501 (-4.5A)
45D  A 501 ( 3.5A)
45D  A 501 (-2.8A)
None
1.00A 1tw4B-5hgrA:
2.1
1tw4B-5hgrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l08 CASPASE-8

(Homo sapiens)
PF01335
(DED)
5 LEU A 160
LEU A 157
ILE A 142
ILE A 174
LEU A 171
None
1.25A 1tw4B-5l08A:
undetectable
1tw4B-5l08A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN


(Lactobacillus
reuteri)
no annotation 5 LEU A 440
LEU A 393
ILE A 447
ILE A 432
LEU A 472
None
1.23A 1tw4B-5nxkA:
undetectable
1tw4B-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL


(Homo sapiens)
PF07147
(PDCD9)
5 LEU 5 113
ILE 5 314
THR 5 126
ILE 5 262
LEU 5 265
None
1.03A 1tw4B-5ool5:
undetectable
1tw4B-5ool5:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae)
PF00806
(PUF)
5 LEU A 461
LEU A 472
ILE A 518
ILE A 506
LEU A 510
LEU  A 461 ( 0.6A)
LEU  A 472 ( 0.5A)
ILE  A 518 ( 0.7A)
ILE  A 506 ( 0.7A)
LEU  A 510 ( 0.6A)
1.22A 1tw4B-5svdA:
undetectable
1tw4B-5svdA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum)
PF00668
(Condensation)
5 TYR A 482
LEU A 448
ILE A 315
HIS A 287
LEU A 479
None
1.26A 1tw4B-5t81A:
undetectable
1tw4B-5t81A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D


(Methylobacterium
extorquens)
no annotation 5 TYR A  64
ILE A  68
ARG A  91
HIS A  41
ARG A  61
None
1.22A 1tw4B-5vrcA:
undetectable
1tw4B-5vrcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4b GTPASE DER

(Bacillus
subtilis)
PF01926
(MMR_HSR1)
5 LEU A 116
LEU A 107
THR A  58
ILE A 144
LEU A 155
None
0.94A 1tw4B-5x4bA:
undetectable
1tw4B-5x4bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3


(Saccharomyces
cerevisiae)
no annotation 5 TYR A 215
LEU A 141
LEU A 107
ILE A 175
LEU A 211
None
1.22A 1tw4B-5xynA:
undetectable
1tw4B-5xynA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3


(Saccharomyces
cerevisiae)
no annotation 5 TYR A 215
LEU A 160
LEU A 107
ILE A 175
LEU A 211
None
1.13A 1tw4B-5xynA:
undetectable
1tw4B-5xynA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 5 LEU A2358
LEU A2354
LEU A2405
ILE A2296
ILE A2315
None
1.28A 1tw4B-6b3rA:
undetectable
1tw4B-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN


(Vibrio
cholerae;
Streptococcus
pyogenes)
no annotation 5 LEU A 586
LEU A 562
LEU A 568
ILE A 610
ILE A 510
None
1.26A 1tw4B-6en3A:
undetectable
1tw4B-6en3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4


(Mus musculus)
no annotation 5 TYR M  95
LEU M  99
LEU M 102
ILE M 225
ILE M 131
None
1.16A 1tw4B-6g2jM:
undetectable
1tw4B-6g2jM:
undetectable