SIMILAR PATTERNS OF AMINO ACIDS FOR 1TW4_A_CHDA131

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		5 LEU A 139
ILE A 118
THR A 147
VAL A 164
PHE A 144
 None
 1.45A 1tw4A-1b2hA:
undetectable		 1tw4A-1b2hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1p TYROSINE PHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01451
(LMWPc) 		5 ILE A  12
THR A  48
LEU A 101
PHE A  84
HIS A  83
 None
 1.14A 1tw4A-1d1pA:
undetectable		 1tw4A-1d1pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		5 ILE A 332
THR A 351
LEU A 299
VAL A 308
PHE A  33
 None
 1.41A 1tw4A-1hleA:
0.3		 1tw4A-1hleA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		5 ILE A  15
LEU A  19
VAL A 200
THR A 199
PHE A 221
 None
 1.48A 1tw4A-1jztA:
0.0		 1tw4A-1jztA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 LEU A 321
ILE A  68
LEU A  70
VAL A  85
GLN A 111
 NAD  A 900 (-4.3A)
None
None
None
None
 0.98A 1tw4A-1la2A:
0.0		 1tw4A-1la2A:
13.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		5 ASN A  60
ILE A  70
VAL A  82
HIS A  98
GLN A 100
 None
 0.97A 1tw4A-1p6pA:
19.9		 1tw4A-1p6pA:
66.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		5 ASN A 524
ILE A 536
LEU A 544
THR A 613
PHE A 550
 None
 1.40A 1tw4A-1pxyA:
undetectable		 1tw4A-1pxyA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A  89
ILE A  17
THR A  99
VAL A  47
THR A  56
 None
 1.33A 1tw4A-1q3bA:
0.0		 1tw4A-1q3bA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q98 THIOL PEROXIDASE

(Haemophilus
influenzae) 		PF08534
(Redoxin) 		5 ILE A 134
LYS A  46
LEU A  48
VAL A 118
PHE A  26
 None
 1.45A 1tw4A-1q98A:
0.0		 1tw4A-1q98A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		5 LEU A 148
ILE A 133
LEU A 126
PHE A 138
HIS A 137
 None
 1.15A 1tw4A-1qyrA:
0.0		 1tw4A-1qyrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens;
Homo sapiens) 		PF00899
(ThiF)
PF00899
(ThiF)
PF08825
(E2_bind) 		5 ILE A 493
THR A 492
LEU A 158
PHE B  23
HIS B  19
 None
 1.43A 1tw4A-1r4nA:
undetectable		 1tw4A-1r4nA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhc PUTATIVE KHG/KDPG
ALDOLASE

(Haemophilus
influenzae) 		PF01081
(Aldolase) 		5 ILE A   9
LYS A  11
LEU A  12
THR A 112
PHE A  90
 None
 1.38A 1tw4A-1vhcA:
undetectable		 1tw4A-1vhcA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ILE A 243
THR A 245
VAL A 230
THR A 226
GLN A  75
 None
 1.43A 1tw4A-1vrdA:
undetectable		 1tw4A-1vrdA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 ILE B  34
THR B  32
LYS B 165
LEU B 167
THR B 187
 None
 1.11A 1tw4A-1y56B:
undetectable		 1tw4A-1y56B:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgh METHIONYL-TRNA
FORMYLTRANSFERASE

(Ruminiclostridium
thermocellum) 		PF00551
(Formyl_trans_N) 		5 LEU A  78
ILE A  95
THR A  98
LEU A  90
PHE A 162
 None
 1.38A 1tw4A-1zghA:
undetectable		 1tw4A-1zghA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 ASN A  87
THR A 184
LEU A 230
VAL A 328
PHE A 285
 None
 1.32A 1tw4A-1zwxA:
undetectable		 1tw4A-1zwxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 359
ILE A 294
LEU A 292
THR A 317
PHE A 266
 None
 1.36A 1tw4A-2awaA:
1.4		 1tw4A-2awaA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE A 183
THR A 182
LEU A 265
VAL A 231
GLN A 208
 None
None
None
None
MG  A 602 (-4.2A)
 1.13A 1tw4A-2f43A:
undetectable		 1tw4A-2f43A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A  80
ASN A 112
ILE A  90
LEU A  69
PHE A  98
 None
 1.23A 1tw4A-2ft3A:
undetectable		 1tw4A-2ft3A:
17.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		6 ASN A  60
ILE A  70
VAL A  82
PHE A  96
HIS A  98
GLN A 100
 None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 0.80A 1tw4A-2ftbA:
22.7		 1tw4A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		5 THR A  71
VAL A  82
PHE A  96
HIS A  98
GLN A 100
 None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 1.03A 1tw4A-2ftbA:
22.7		 1tw4A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 LEU A 197
ILE A 146
LEU A 143
VAL A  68
PHE A  89
 None
 1.36A 1tw4A-2o7rA:
undetectable		 1tw4A-2o7rA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 423
ASN A 325
ILE A 328
LEU A 565
VAL A 466
 None
 1.47A 1tw4A-2ongA:
undetectable		 1tw4A-2ongA:
12.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 ASN A  60
THR A  72
VAL A  82
HIS A  98
GLN A 100
 IPA  A 141 ( 4.7A)
GOL  A 145 (-3.2A)
None
IPA  A 140 (-3.7A)
IPA  A 142 (-3.5A)
 0.78A 1tw4A-2qo4A:
21.6		 1tw4A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE A 184
THR A 183
LEU A 258
VAL A 224
GLN A 201
 None
 1.15A 1tw4A-2r9vA:
undetectable		 1tw4A-2r9vA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 538
ASN A 592
ILE A 570
LEU A 548
PHE A 578
 None
 1.39A 1tw4A-2v70A:
undetectable		 1tw4A-2v70A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU B 374
ASN B 406
ILE B 384
LEU B 363
PHE B 392
 None
 1.33A 1tw4A-2v9tB:
undetectable		 1tw4A-2v9tB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 281
ILE A 201
LEU A 333
VAL A 324
THR A 314
 None
 1.11A 1tw4A-2vk4A:
undetectable		 1tw4A-2vk4A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 803
ASN A 835
LEU A 792
VAL A 840
PHE A 821
 None
 1.42A 1tw4A-2wfhA:
undetectable		 1tw4A-2wfhA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xok ATP SYNTHASE SUBUNIT
GAMMA, MITOCHONDRIAL
ATP SYNTHASE

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00231
(ATP-synt)
PF02823
(ATP-synt_DE_N) 		5 THR G 213
LEU G 209
THR H  76
PHE G  51
GLN H  13
 None
 1.42A 1tw4A-2xokG:
undetectable		 1tw4A-2xokG:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 115
ASN A 168
ILE A 146
LEU A 125
PHE A 154
 None
 1.46A 1tw4A-2xotA:
undetectable		 1tw4A-2xotA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A 510
ILE A 421
VAL A 465
THR A 466
PHE A 523
 None
 1.20A 1tw4A-2xswA:
undetectable		 1tw4A-2xswA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwx GLCNAC-BINDING
PROTEIN A

(Vibrio cholerae) 		PF03067
(LPMO_10) 		5 LEU A 254
ILE A 268
THR A 266
VAL A 305
THR A 231
 None
 1.41A 1tw4A-2xwxA:
undetectable		 1tw4A-2xwxA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3

(Mus musculus) 		PF00621
(RhoGEF) 		5 LEU A 248
THR A 251
LEU A 207
PHE A 244
HIS A 228
 None
 1.29A 1tw4A-2z0qA:
undetectable		 1tw4A-2z0qA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 498
ASN A 530
LEU A 488
VAL A 535
PHE A 516
 None
 1.37A 1tw4A-2z63A:
undetectable		 1tw4A-2z63A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B  71
ASN B 103
ILE B  81
LEU B  60
PHE B  89
 None
 1.40A 1tw4A-2z7xB:
undetectable		 1tw4A-2z7xB:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		5 ASN A  59
ILE A  58
LEU A  41
PHE A 126
HIS A 226
 None
 1.21A 1tw4A-2zu0A:
undetectable		 1tw4A-2zu0A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B  78
ASN B 110
ILE B  88
LEU B  67
PHE B  96
 None
 1.31A 1tw4A-3a79B:
undetectable		 1tw4A-3a79B:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		5 LEU A  14
ILE A  80
THR A  82
LYS A  86
LEU A  88
 None
 0.90A 1tw4A-3bbhA:
undetectable		 1tw4A-3bbhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byh FIMBRIN ABD2

(Homo sapiens) 		PF00307
(CH) 		5 ASN B 524
ILE B 536
LEU B 544
THR B 613
PHE B 550
 None
 1.40A 1tw4A-3byhB:
undetectable		 1tw4A-3byhB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byi RHO GTPASE
ACTIVATING PROTEIN
15

(Homo sapiens) 		PF00620
(RhoGAP) 		5 ASN A 423
ILE A 416
LEU A 430
VAL A 305
HIS A 349
 None
 1.47A 1tw4A-3byiA:
undetectable		 1tw4A-3byiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		5 ASN A 221
LEU A 197
THR A 214
PHE A  38
HIS A  37
 None
 1.24A 1tw4A-3cgxA:
undetectable		 1tw4A-3cgxA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 384
ASN A 441
ILE A 419
LEU A 393
PHE A 401
 None
 1.32A 1tw4A-3ciyA:
undetectable		 1tw4A-3ciyA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 404
ASN A 441
ILE A 419
LEU A 396
PHE A 427
 None
 1.33A 1tw4A-3ciyA:
undetectable		 1tw4A-3ciyA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 109
LYS A 114
LEU A 110
VAL A 156
PHE A 163
 None
 1.24A 1tw4A-3kb6A:
undetectable		 1tw4A-3kb6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A 275
ASN A 217
ILE A 219
THR A 249
PHE A 262
 None
 1.43A 1tw4A-3kq4A:
undetectable		 1tw4A-3kq4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 390
THR A 393
LEU A 220
VAL A 352
THR A 353
 None
 1.22A 1tw4A-3mogA:
undetectable		 1tw4A-3mogA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
OXIDASE

(Streptococcus
mutans) 		PF01180
(DHO_dh) 		5 ILE A 140
THR A 147
LEU A 129
THR A 109
HIS A 110
 None
None
None
None
MLY  A 114 ( 4.8A)
 0.96A 1tw4A-3oixA:
undetectable		 1tw4A-3oixA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 LEU A 467
VAL A 426
THR A 445
HIS A 390
GLN A 367
 None
 1.38A 1tw4A-3omlA:
1.4		 1tw4A-3omlA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		5 ASN A  13
ILE A   9
LEU A  61
VAL A  26
PHE A  73
 None
 1.15A 1tw4A-3qdnA:
undetectable		 1tw4A-3qdnA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A  78
THR A  92
LEU A  81
VAL A  25
THR A 117
 None
 1.09A 1tw4A-3qn3A:
undetectable		 1tw4A-3qn3A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpd CUTINASE 1

(Aspergillus
oryzae) 		PF01083
(Cutinase) 		5 LEU A 152
ILE A 120
VAL A 143
PHE A 168
GLN A 105
 None
 1.29A 1tw4A-3qpdA:
undetectable		 1tw4A-3qpdA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU A  58
ILE A  89
LEU A  65
THR A  96
PHE A  73
 None
 1.47A 1tw4A-3t6qA:
undetectable		 1tw4A-3t6qA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		5 LEU A 175
THR A  95
LYS A  11
LEU A 120
PHE A 154
 None
 1.24A 1tw4A-3um1A:
undetectable		 1tw4A-3um1A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 342
ASN A 350
ILE A 328
LEU A 307
PHE A 336
 None
 1.43A 1tw4A-3v44A:
undetectable		 1tw4A-3v44A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 701
ASN A 733
ILE A 711
LEU A 690
PHE A 719
 None
 1.31A 1tw4A-3wpeA:
undetectable		 1tw4A-3wpeA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 701
ASN A 733
LEU A 690
VAL A 738
PHE A 719
 None
 1.20A 1tw4A-3wpeA:
undetectable		 1tw4A-3wpeA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx METASTASIS-ASSOCIATE
D PROTEIN MTA1
HISTONE DEACETYLASE
1

(Homo sapiens;
Homo sapiens) 		PF00249
(Myb_DNA-binding)
PF01448
(ELM2)
PF00850
(Hist_deacetyl) 		5 ASN B 225
THR B 208
LYS A 165
HIS B 140
GLN B 260
 None
None
None
ACT  B 601 (-3.7A)
None
 1.36A 1tw4A-4bkxB:
undetectable		 1tw4A-4bkxB:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ASN A 188
ILE A 191
THR A 122
LEU A 118
PHE A 133
 None
 1.44A 1tw4A-4c23A:
undetectable		 1tw4A-4c23A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d73 1-CYS PEROXIREDOXIN

(Plasmodium
falciparum) 		PF08534
(Redoxin) 		5 LEU B 106
VAL B  68
THR B  95
PHE B  99
HIS B  96
 None
 1.41A 1tw4A-4d73B:
undetectable		 1tw4A-4d73B:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		5 LEU A 137
ILE A 107
THR A 157
LEU A 155
VAL A  95
 None
 1.33A 1tw4A-4ge0A:
undetectable		 1tw4A-4ge0A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h40 PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF15415
(Mfa_like_2) 		5 LEU A 333
ILE A 288
LEU A 307
VAL A 278
PHE A 207
 None
 1.42A 1tw4A-4h40A:
undetectable		 1tw4A-4h40A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iob DIGUANYLATE CYCLASE
TPBB

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 ASN A 309
ILE A 360
THR A 305
LEU A 362
THR A 370
 None
 1.48A 1tw4A-4iobA:
undetectable		 1tw4A-4iobA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 ILE A 103
THR A 256
LEU A 262
VAL A 321
GLN A 107
 None
 1.48A 1tw4A-4iwhA:
undetectable		 1tw4A-4iwhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 367
ASN A 399
ILE A 377
LEU A 358
PHE A 385
 None
 1.34A 1tw4A-4kt1A:
undetectable		 1tw4A-4kt1A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 LEU C  63
ILE C 125
LEU C 123
PHE C  61
GLN C   2
 None
 1.43A 1tw4A-4lccC:
undetectable		 1tw4A-4lccC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 370
ASN A 402
ILE A 380
LEU A 361
PHE A 388
 None
 1.38A 1tw4A-4li2A:
undetectable		 1tw4A-4li2A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 ILE A1163
THR A1230
LEU A1226
VAL A1146
PHE A1199
 None
 1.28A 1tw4A-4ll6A:
undetectable		 1tw4A-4ll6A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 132
ILE A 111
LYS A  82
LEU A  84
PHE A  42
 None
 1.39A 1tw4A-4m7eA:
undetectable		 1tw4A-4m7eA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		5 LEU A 181
ASN A 213
LEU A 170
VAL A 218
PHE A 199
 None
 1.47A 1tw4A-4p8sA:
undetectable		 1tw4A-4p8sA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM

(Leptospira
biflexa) 		PF00072
(Response_reg) 		5 LEU A  14
ILE A   5
LEU A  22
VAL A 117
PHE A 110
 None
 1.24A 1tw4A-4q7eA:
undetectable		 1tw4A-4q7eA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 283
ASN A 315
ILE A 293
LEU A 272
PHE A 301
 None
 1.32A 1tw4A-4qdhA:
undetectable		 1tw4A-4qdhA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 367
ASN A 399
ILE A 377
LEU A 358
PHE A 385
 None
 1.22A 1tw4A-4qxeA:
undetectable		 1tw4A-4qxeA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 LEU A 128
ILE A 339
THR A  85
LEU A 376
THR A 322
 None
None
None
None
TRP  A 503 (-4.4A)
 1.24A 1tw4A-4r33A:
undetectable		 1tw4A-4r33A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		5 LEU A 193
ASN A 100
THR A 116
PHE A 166
GLN A 111
 None
 1.40A 1tw4A-4r3uA:
undetectable		 1tw4A-4r3uA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita) 		PF13517
(VCBS) 		5 ASN A 145
THR A  67
LEU A 121
VAL A 142
PHE A  78
 None
 1.41A 1tw4A-4tqkA:
undetectable		 1tw4A-4tqkA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF08662
(eIF2A) 		5 LEU A 501
ILE A 465
THR A 464
THR A 508
GLN A 538
 None
 1.26A 1tw4A-4u1fA:
1.9		 1tw4A-4u1fA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 293
ASN A 325
ILE A 303
LEU A 282
PHE A 311
 None
 1.38A 1tw4A-4u7lA:
undetectable		 1tw4A-4u7lA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 341
ASN A 325
ILE A 303
LEU A 282
THR A 330
 None
 1.24A 1tw4A-4u7lA:
undetectable		 1tw4A-4u7lA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3B

(Lachancea
kluyveri) 		PF00318
(Ribosomal_S2) 		5 LEU b 567
ILE b 531
THR b 530
THR b 574
GLN b 604
 None
 1.25A 1tw4A-4uerb:
2.0		 1tw4A-4uerb:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		5 ILE A 306
LEU A 305
VAL A 365
HIS A 209
GLN A 433
 None
 0.93A 1tw4A-4v1uA:
undetectable		 1tw4A-4v1uA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe7 UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		no annotation 5 LEU A  82
ILE A 167
LEU A 171
THR A  17
HIS A 126
 None
 1.10A 1tw4A-4xe7A:
undetectable		 1tw4A-4xe7A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 129
ASN A 161
ILE A 139
LEU A 118
PHE A 147
 None
 1.27A 1tw4A-4z0cA:
undetectable		 1tw4A-4z0cA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		5 ILE A 264
THR A 263
LEU A 267
VAL A  60
PHE A 209
 None
 1.34A 1tw4A-5dxlA:
undetectable		 1tw4A-5dxlA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 714
ASN A 746
ILE A 724
LEU A 703
PHE A 731
 None
 1.09A 1tw4A-5hdhA:
undetectable		 1tw4A-5hdhA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A  71
ILE A 343
LEU A  30
VAL A 328
GLN A 229
 None
 1.15A 1tw4A-5iq0A:
undetectable		 1tw4A-5iq0A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu1 CTR1-LIKE PROTEIN

(Physcomitrella
patens) 		PF00989
(PAS) 		5 LEU A  23
ILE A   7
LEU A  36
VAL A  56
PHE A  66
 None
 1.34A 1tw4A-5iu1A:
undetectable		 1tw4A-5iu1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
 None
 1.34A 1tw4A-5ko3A:
undetectable		 1tw4A-5ko3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 149
ASN A 181
ILE A 159
LEU A 138
PHE A 167
 None
 1.22A 1tw4A-5lfnA:
undetectable		 1tw4A-5lfnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8y EPOXYQUEUOSINE
REDUCTASE

(Bacillus
subtilis) 		PF08331
(DUF1730)
PF13484
(Fer4_16)
PF13646
(HEAT_2) 		5 ASN A 175
ILE A 127
THR A 129
LEU A 120
VAL A   3
 None
 1.32A 1tw4A-5t8yA:
undetectable		 1tw4A-5t8yA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 5 ASN A  92
ILE A  98
THR A  79
LEU A  36
GLN A 152
 None
 1.40A 1tw4A-5txfA:
undetectable		 1tw4A-5txfA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
 None
 1.30A 1tw4A-5w8uA:
undetectable		 1tw4A-5w8uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF12680
(SnoaL_2) 		5 LEU A 236
ILE A 272
THR A 270
LEU A 282
VAL A 174
 None
 1.38A 1tw4A-5xe7A:
undetectable		 1tw4A-5xe7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 703
ASN A 735
ILE A 713
LEU A 692
PHE A 721
 None
 1.35A 1tw4A-5y3jA:
undetectable		 1tw4A-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 703
ASN A 735
LEU A 692
VAL A 740
PHE A 721
 None
 1.16A 1tw4A-5y3jA:
undetectable		 1tw4A-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ASN A 175
ILE A 136
THR A 137
LYS A 139
THR A 133
 None
 1.01A 1tw4A-5yvsA:
undetectable		 1tw4A-5yvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 704
ASN A 736
ILE A 714
LEU A 693
PHE A 722
 None
 1.32A 1tw4A-5zlnA:
undetectable		 1tw4A-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 704
ASN A 736
LEU A 693
VAL A 741
PHE A 722
 None
 1.15A 1tw4A-5zlnA:
undetectable		 1tw4A-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 LEU A 401
ASN A 380
ILE A 375
LEU A 336
PHE A 297
 None
 1.44A 1tw4A-6c4gA:
undetectable		 1tw4A-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 ILE C 184
THR C 183
LEU C 258
VAL C 224
GLN C 201
 None
 0.98A 1tw4A-6fkhC:
undetectable		 1tw4A-6fkhC:
undetectable