SIMILAR PATTERNS OF AMINO ACIDS FOR 1TW4_A_CHDA130_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 TYR A 594
ARG A 533
GLN A 529
 None
 0.83A 1tw4A-1ddgA:
0.0		 1tw4A-1ddgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 491
ARG C 245
GLN A 454
 None
 1.03A 1tw4A-1e6vA:
0.0		 1tw4A-1e6vA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 TYR B2215
ARG B2041
GLN B2112
 None
 0.65A 1tw4A-1e6yB:
0.0		 1tw4A-1e6yB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A1508
ARG C3240
GLN A1471
 None
 0.95A 1tw4A-1e6yA:
0.0		 1tw4A-1e6yA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		3 TYR A 328
ARG A 189
GLN A 185
 None
 0.96A 1tw4A-1l5aA:
0.0		 1tw4A-1l5aA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF01074
(Glyco_hydro_38)
PF09261
(Alpha-mann_mid) 		3 TYR B 359
ARG A 229
GLN A 234
 None
 0.94A 1tw4A-1o7dB:
undetectable		 1tw4A-1o7dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 TYR A 188
ARG A  86
GLN A  81
 None
 1.02A 1tw4A-1ofeA:
3.6		 1tw4A-1ofeA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi1 SCML2 PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		3 TYR A 215
ARG A 222
GLN A  54
 None
 0.96A 1tw4A-1oi1A:
undetectable		 1tw4A-1oi1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR A 278
ARG A 249
GLN A 247
 None
 1.00A 1tw4A-1pd1A:
undetectable		 1tw4A-1pd1A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		3 TYR A 355
ARG A 363
GLN A 360
 None
 0.87A 1tw4A-1slqA:
1.3		 1tw4A-1slqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 TYR A 137
ARG A 167
GLN A 164
 None
 1.01A 1tw4A-1t1uA:
undetectable		 1tw4A-1t1uA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 TYR A 696
ARG A 617
GLN A 613
 None
 1.00A 1tw4A-1taqA:
undetectable		 1tw4A-1taqA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TYR A 115
ARG A  48
GLN A  44
 None
 1.00A 1tw4A-1ukwA:
undetectable		 1tw4A-1ukwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 TYR A 649
ARG A 632
GLN A 690
 None
 1.00A 1tw4A-1zcjA:
undetectable		 1tw4A-1zcjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		3 TYR A 235
ARG A 208
GLN A 142
 None
ADP  A 500 (-4.3A)
None
 0.95A 1tw4A-2bejA:
undetectable		 1tw4A-2bejA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN

(Mycoplasma
arthritidis) 		PF09245
(MA-Mit) 		3 TYR G  33
ARG G  57
GLN G  54
 None
 0.96A 1tw4A-2icwG:
undetectable		 1tw4A-2icwG:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 116
ARG A 126
GLN A 127
 None
 0.98A 1tw4A-2jc6A:
undetectable		 1tw4A-2jc6A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		3 TYR A 203
ARG A 159
GLN A 261
 None
 0.94A 1tw4A-2kdyA:
3.4		 1tw4A-2kdyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0k POLYCOMB PROTEIN
SCMH1

(Homo sapiens) 		PF02820
(MBT) 		3 TYR A 210
ARG A 217
GLN A  49
 None
 0.88A 1tw4A-2p0kA:
undetectable		 1tw4A-2p0kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7b ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
agalactiae) 		PF00583
(Acetyltransf_1) 		3 TYR A 130
ARG A 152
GLN A  24
 None
FLC  A 164 (-4.3A)
FLC  A 164 (-3.9A)
 0.82A 1tw4A-2q7bA:
undetectable		 1tw4A-2q7bA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 TYR A 290
ARG A 423
GLN A 351
 None
 1.00A 1tw4A-2qfrA:
undetectable		 1tw4A-2qfrA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 TYR A  82
ARG A 192
GLN A 160
 None
 0.98A 1tw4A-2qt3A:
undetectable		 1tw4A-2qt3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5m POLYCOMB PROTEIN SCM

(Drosophila
melanogaster) 		PF02820
(MBT) 		3 TYR A 357
ARG A 364
GLN A 196
 None
 0.90A 1tw4A-2r5mA:
undetectable		 1tw4A-2r5mA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 TYR A 649
ARG A 632
GLN A 690
 None
 0.94A 1tw4A-2x58A:
undetectable		 1tw4A-2x58A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x75 ADENYLOSUCCINATE
LYASE

(Staphylococcus
aureus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 TYR A  20
ARG A  67
GLN A  64
 None
 0.95A 1tw4A-2x75A:
undetectable		 1tw4A-2x75A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8k HYPOTHETICAL PROTEIN
19.1

(Bacillus phage
SPP1) 		PF05709
(Sipho_tail) 		3 TYR A 137
ARG A 109
GLN A 132
 None
 1.01A 1tw4A-2x8kA:
undetectable		 1tw4A-2x8kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		3 TYR A 187
ARG A 197
GLN A 198
 None
 0.97A 1tw4A-2y27A:
undetectable		 1tw4A-2y27A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		3 TYR A 177
ARG A  99
GLN A  95
 None
 0.96A 1tw4A-2y8vA:
undetectable		 1tw4A-2y8vA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 TYR A 150
ARG A 270
GLN A  75
 None
 0.93A 1tw4A-2yfnA:
undetectable		 1tw4A-2yfnA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxk VOLTAGE-DEPENDENT
P/Q-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1A PEPTIDE

(Homo sapiens) 		no annotation 3 TYR B1962
ARG B1972
GLN B1973
 None
 0.93A 1tw4A-3bxkB:
undetectable		 1tw4A-3bxkB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		3 TYR A 311
ARG A  27
GLN A  23
 None
None
CL  A 332 (-4.2A)
 0.95A 1tw4A-3c17A:
undetectable		 1tw4A-3c17A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		3 TYR A 249
ARG A  77
GLN A  72
 None
 0.98A 1tw4A-3dcdA:
1.6		 1tw4A-3dcdA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 154
ARG A 337
GLN A 323
 None
 0.97A 1tw4A-3eezA:
undetectable		 1tw4A-3eezA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 159
ARG A 337
GLN A 323
 None
 0.88A 1tw4A-3eezA:
undetectable		 1tw4A-3eezA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		3 TYR A 348
ARG A 281
GLN A 278
 None
 0.79A 1tw4A-3fipA:
2.8		 1tw4A-3fipA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		3 TYR A 308
ARG A 162
GLN A 159
 None
 1.00A 1tw4A-3g68A:
undetectable		 1tw4A-3g68A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		3 TYR A 124
ARG A 114
GLN A  65
 None
SO4  A 326 (-4.4A)
None
 0.92A 1tw4A-3kskA:
undetectable		 1tw4A-3kskA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		3 TYR A 284
ARG A 274
GLN A 225
 None
 0.87A 1tw4A-3kskA:
undetectable		 1tw4A-3kskA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 3 TYR B 440
ARG B 427
GLN B 423
 None
 1.02A 1tw4A-3kx2B:
undetectable		 1tw4A-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3laq UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR

(Mus musculus) 		PF00021
(UPAR_LY6) 		3 TYR U 141
ARG U 214
GLN U 183
 None
 0.89A 1tw4A-3laqU:
undetectable		 1tw4A-3laqU:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mel THIAMIN
PYROPHOSPHOKINASE
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 TYR A 139
ARG A 120
GLN A  81
 None
 0.93A 1tw4A-3melA:
undetectable		 1tw4A-3melA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		3 TYR A 125
ARG A 118
GLN A 119
 None
 0.99A 1tw4A-3nixA:
undetectable		 1tw4A-3nixA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A 303
ARG A 130
GLN A 127
 None
 1.00A 1tw4A-3nizA:
undetectable		 1tw4A-3nizA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		3 TYR B 248
ARG B 362
GLN B 359
 None
 0.96A 1tw4A-3nvnB:
1.7		 1tw4A-3nvnB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o44 HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		3 TYR A 194
ARG A 531
GLN A 526
 None
 0.92A 1tw4A-3o44A:
1.6		 1tw4A-3o44A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 TYR A 548
ARG A 100
GLN A  97
 None
 1.01A 1tw4A-3pieA:
undetectable		 1tw4A-3pieA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica;
Salmonella
enterica) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		3 TYR B  16
ARG A 140
GLN A 141
 None
 0.96A 1tw4A-3pr2B:
undetectable		 1tw4A-3pr2B:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90) 		3 TYR A 493
ARG A 456
GLN A 532
 None
 0.99A 1tw4A-3q6mA:
undetectable		 1tw4A-3q6mA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon;
uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 507
ARG C 244
GLN A 470
 None
 0.98A 1tw4A-3sqgA:
undetectable		 1tw4A-3sqgA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1

(Burkholderia
ambifaria) 		PF00793
(DAHP_synth_1) 		3 TYR A  53
ARG A  81
GLN A  82
 None
 1.00A 1tw4A-3t4cA:
undetectable		 1tw4A-3t4cA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A
ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
PF12705
(PDDEXK_1) 		3 TYR B 366
ARG A 741
GLN A 737
 None
 1.03A 1tw4A-3u44B:
undetectable		 1tw4A-3u44B:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 TYR A 124
ARG A 136
GLN A  77
 None
 0.94A 1tw4A-3ufbA:
undetectable		 1tw4A-3ufbA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgh REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Thermoanaerobacter
ethanolicus) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		3 TYR A  66
ARG A  14
GLN A  48
 None
 0.97A 1tw4A-3wghA:
undetectable		 1tw4A-3wghA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh7 PROTEIN E

(Haemophilus
influenzae) 		PF16747
(Adhesin_E) 		3 TYR A  81
ARG A  92
GLN A 118
 None
 0.82A 1tw4A-3zh7A:
2.6		 1tw4A-3zh7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		3 TYR A 464
ARG A 204
GLN A 354
 None
 0.96A 1tw4A-4a1fA:
undetectable		 1tw4A-4a1fA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		3 TYR A 391
ARG A  44
GLN A  47
 None
 1.03A 1tw4A-4drsA:
undetectable		 1tw4A-4drsA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 TYR A  95
ARG A 162
GLN A 180
 None
SSA  A1001 (-2.8A)
SSA  A1001 (-3.4A)
 0.94A 1tw4A-4eo4A:
undetectable		 1tw4A-4eo4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 TYR A 150
ARG A 270
GLN A  74
 None
 0.91A 1tw4A-4fnqA:
undetectable		 1tw4A-4fnqA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		3 TYR A  80
ARG A 204
GLN A 201
 None
 1.00A 1tw4A-4hb9A:
undetectable		 1tw4A-4hb9A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		3 TYR C 189
ARG C  61
GLN C 278
 None
 0.89A 1tw4A-4ifdC:
undetectable		 1tw4A-4ifdC:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 TYR A 247
ARG A 406
GLN A 119
 None
 0.81A 1tw4A-4k3yA:
undetectable		 1tw4A-4k3yA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		3 TYR A  34
ARG A  73
GLN A 112
 None
 0.93A 1tw4A-4kdsA:
undetectable		 1tw4A-4kdsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		3 TYR A 201
ARG A  70
GLN A 259
 None
 0.92A 1tw4A-4mt6A:
undetectable		 1tw4A-4mt6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohx PROTEIN CLPF-1

(Caenorhabditis
elegans) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		3 TYR A 200
ARG A 297
GLN A 154
 None
None
ADP  A 501 ( 4.7A)
 0.96A 1tw4A-4ohxA:
undetectable		 1tw4A-4ohxA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		3 TYR A 120
ARG A 149
GLN A 176
 None
LFC  A 403 (-2.7A)
LFC  A 403 ( 4.7A)
 1.02A 1tw4A-4ovtA:
undetectable		 1tw4A-4ovtA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozd 14.4 KDA SALIVARY
PROTEIN

(Phlebotomus
duboscqi) 		PF01395
(PBP_GOBP) 		3 TYR A  94
ARG A  44
GLN A  40
 None
 0.85A 1tw4A-4ozdA:
undetectable		 1tw4A-4ozdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 TYR A1867
ARG A1797
GLN A1794
 None
 1.01A 1tw4A-4p1tA:
undetectable		 1tw4A-4p1tA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		3 TYR A 106
ARG A 140
GLN A 138
 None
 1.01A 1tw4A-4pz7A:
undetectable		 1tw4A-4pz7A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B  38
ARG B 136
GLN B  74
 None
 0.92A 1tw4A-4qiwB:
undetectable		 1tw4A-4qiwB:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		3 TYR A 190
ARG A 116
GLN A 113
 None
None
ANP  A 402 ( 4.2A)
 0.89A 1tw4A-4qnyA:
undetectable		 1tw4A-4qnyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGS

(Sphingomonas
sp.;
Sphingomonas
sp.) 		PF00528
(BPD_transp_1)
PF00005
(ABC_tran)
PF03459
(TOBE) 		3 TYR C  88
ARG A 226
GLN A 220
 None
 0.84A 1tw4A-4tqvC:
undetectable		 1tw4A-4tqvC:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 TYR A 128
ARG A 138
GLN A 139
 None
 1.00A 1tw4A-4uj6A:
undetectable		 1tw4A-4uj6A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uut HOMEOTIC PROTEIN
ULTRABITHORAX

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		3 TYR A   8
ARG A  53
GLN A  50
 None
SO4  A1074 (-4.0A)
None
 1.03A 1tw4A-4uutA:
undetectable		 1tw4A-4uutA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		3 TYR A  92
ARG A 244
GLN A  37
 None
 0.80A 1tw4A-4w8oA:
undetectable		 1tw4A-4w8oA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 TYR A 114
ARG A  77
GLN A  73
 None
 0.93A 1tw4A-4wboA:
undetectable		 1tw4A-4wboA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 TYR A2420
ARG A2337
GLN A2333
 None
 1.00A 1tw4A-4x0qA:
undetectable		 1tw4A-4x0qA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 TYR A  31
ARG A  43
GLN A  44
 CTP  A 402 ( 3.9A)
None
None
 0.87A 1tw4A-4xsvA:
undetectable		 1tw4A-4xsvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 TYR A 162
ARG A 155
GLN A 156
 None
 0.93A 1tw4A-4yv2A:
undetectable		 1tw4A-4yv2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 490
ARG C 244
GLN A 453
 None
None
DYA  A 452 ( 4.6A)
 0.91A 1tw4A-5a8rA:
undetectable		 1tw4A-5a8rA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		3 TYR A1120
ARG A 292
GLN A 291
 G  C   7 ( 3.5A)
U  C   6 ( 3.1A)
U  C   6 ( 4.1A)
 0.97A 1tw4A-5amqA:
undetectable		 1tw4A-5amqA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Mus musculus) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		3 TYR A 110
ARG A  86
GLN A  83
 None
 1.00A 1tw4A-5axiA:
undetectable		 1tw4A-5axiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii;
Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		3 TYR A 611
ARG B  10
GLN A 436
 None
 0.85A 1tw4A-5c6gA:
undetectable		 1tw4A-5c6gA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		3 TYR A1453
ARG A1426
GLN A1605
 None
 0.89A 1tw4A-5czvA:
undetectable		 1tw4A-5czvA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 TYR A 224
ARG A  95
GLN A  91
 None
 0.94A 1tw4A-5d79A:
undetectable		 1tw4A-5d79A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		3 TYR A 688
ARG A 240
GLN A 202
 None
 0.99A 1tw4A-5fswA:
undetectable		 1tw4A-5fswA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2
VP3

(Deformed wing
virus;
Deformed wing
virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 TYR B 156
ARG B 214
GLN C  69
 None
 0.96A 1tw4A-5g52B:
undetectable		 1tw4A-5g52B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 TYR A  30
ARG A 288
GLN A 292
 None
 0.87A 1tw4A-5hm5A:
undetectable		 1tw4A-5hm5A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		3 TYR A 701
ARG A 649
GLN A 645
 None
 0.60A 1tw4A-5hzrA:
undetectable		 1tw4A-5hzrA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		3 TYR A 299
ARG A 207
GLN B 120
 None
 0.60A 1tw4A-5ivaA:
1.1		 1tw4A-5ivaA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		3 TYR A  70
ARG A 296
GLN A 392
 None
 1.01A 1tw4A-5j5uA:
undetectable		 1tw4A-5j5uA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		3 TYR B  49
ARG B 480
GLN B 478
 None
 0.78A 1tw4A-5lxzB:
undetectable		 1tw4A-5lxzB:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4y EXOCYST COMPLEX
COMPONENT SEC3

(Saccharomyces
cerevisiae) 		PF15277
(Sec3-PIP2_bind) 		3 TYR B 108
ARG B 113
GLN B  81
 None
 0.99A 1tw4A-5m4yB:
undetectable		 1tw4A-5m4yB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs MICROTUBULE
INTEGRITY PROTEIN
MAL3

(Schizosaccharomyces
pombe) 		no annotation 3 TYR D  58
ARG D 117
GLN D  34
 None
 0.65A 1tw4A-5mjsD:
undetectable		 1tw4A-5mjsD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 490
ARG C 245
GLN A 453
 TRX  A 429 ( 4.8A)
None
None
 0.98A 1tw4A-5n28A:
undetectable		 1tw4A-5n28A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		3 TYR A1308
ARG A1377
GLN A1374
 None
 0.86A 1tw4A-5t03A:
undetectable		 1tw4A-5t03A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi) 		PF06224
(HTH_42) 		3 TYR A  90
ARG A  51
GLN A  16
 None
 0.77A 1tw4A-5uujA:
undetectable		 1tw4A-5uujA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L14
50S RIBOSOMAL
PROTEIN L19

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00238
(Ribosomal_L14)
PF01245
(Ribosomal_L19) 		3 TYR P  65
ARG K 104
GLN P  40
 None
 0.97A 1tw4A-5v7qP:
undetectable		 1tw4A-5v7qP:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 TYR A 450
ARG A 419
GLN A 415
 None
 0.99A 1tw4A-5xfmA:
2.3		 1tw4A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 3 TYR G  55
ARG G  24
GLN G  20
 None
 0.76A 1tw4A-6criG:
undetectable		 1tw4A-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 3 TYR A 367
ARG A 263
GLN A 257
 None
 1.03A 1tw4A-6d35A:
undetectable		 1tw4A-6d35A:
undetectable