SIMILAR PATTERNS OF AMINO ACIDS FOR 1TW4_A_CHDA130_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		5 LEU A 193
LEU A 190
LEU A 152
ILE A 142
LEU A 207
 None
 1.03A 1tw4A-1alqA:
undetectable		 1tw4A-1alqA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 ALA A 171
ILE A 116
ASP A 106
ILE A 189
LEU A 193
 None
 1.12A 1tw4A-1eb3A:
undetectable		 1tw4A-1eb3A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.09A 1tw4A-1es6A:
0.7		 1tw4A-1es6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 371
LEU A 203
ALA A 336
ILE A 335
ILE A  76
 None
 1.07A 1tw4A-1fnoA:
undetectable		 1tw4A-1fnoA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 LEU A 128
LEU A  49
ALA A  57
ILE A  60
LEU A  81
 None
None
None
None
HEC  A 601 (-4.7A)
 1.01A 1tw4A-1gq1A:
0.7		 1tw4A-1gq1A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		5 LEU A 167
LEU A 164
ALA A 139
ILE A 142
ILE A 178
 None
 1.12A 1tw4A-1losA:
undetectable		 1tw4A-1losA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		7 LEU A  18
ALA A  31
THR A  53
HIS A  98
ILE A 111
LEU A 118
ARG A 120
 None
 0.80A 1tw4A-1p6pA:
19.9		 1tw4A-1p6pA:
66.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 639
ALA A 695
ILE A 694
ILE A 556
LEU A 453
 None
 1.13A 1tw4A-1r8wA:
0.0		 1tw4A-1r8wA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 LEU A 248
LEU A 252
ALA A 243
ILE A 176
LEU A 170
 None
 1.11A 1tw4A-1sqhA:
undetectable		 1tw4A-1sqhA:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		5 LEU A  23
ILE A  34
THR A  53
LEU A 118
ARG A 120
 None
 0.74A 1tw4A-1zryA:
12.4		 1tw4A-1zryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		5 LEU A 248
LEU A 247
ILE A 199
MET A 218
ARG A 210
 None
 1.07A 1tw4A-2a5hA:
undetectable		 1tw4A-2a5hA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8i PAS FACTOR

(Vibrio
vulnificus) 		PF09016
(Pas_Saposin) 		5 LEU A  13
LEU A  16
LEU A  58
ALA A  67
LEU A  31
 None
 0.94A 1tw4A-2b8iA:
undetectable		 1tw4A-2b8iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 317
ILE A 346
THR A 348
ILE A 400
LEU A 418
 None
 0.99A 1tw4A-2bv5A:
0.6		 1tw4A-2bv5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 235
LEU A 234
LEU A 247
ALA A 255
ASP A 263
 None
 1.10A 1tw4A-2ctzA:
undetectable		 1tw4A-2ctzA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 235
LEU A 234
LEU A 247
ILE A 257
ASP A 263
 None
 1.01A 1tw4A-2ctzA:
undetectable		 1tw4A-2ctzA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei9 NON-LTR
RETROTRANSPOSON
R1BMKS ORF2 PROTEIN

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		5 LEU A 113
LEU A 110
ALA A  98
ILE A 163
LEU A 168
 None
 1.08A 1tw4A-2ei9A:
undetectable		 1tw4A-2ei9A:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		7 LEU A  18
ALA A  31
ILE A  34
THR A  53
HIS A  98
LEU A 118
ARG A 120
 None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
None
 0.58A 1tw4A-2ftbA:
22.7		 1tw4A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 933
LEU A 977
ALA A 987
ILE A 883
LEU A 893
 None
 1.09A 1tw4A-2gv9A:
undetectable		 1tw4A-2gv9A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hd3 ETHANOLAMINE
UTILIZATION PROTEIN
EUTN

(Escherichia
coli) 		PF03319
(EutN_CcmL) 		5 LEU A  25
LEU A  24
ALA A  49
ILE A  81
LEU A  76
 None
 1.13A 1tw4A-2hd3A:
undetectable		 1tw4A-2hd3A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		6 LEU A  56
ALA A  83
ILE A 118
HIS A 103
ILE A 104
LEU A  91
 None
 1.06A 1tw4A-2hhzA:
1.7		 1tw4A-2hhzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 218
LEU A 215
ILE A 171
HIS A 238
ILE A 250
 None
 0.94A 1tw4A-2hzgA:
undetectable		 1tw4A-2hzgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		5 LEU A 108
LEU A 110
LEU A 160
ALA A  93
ILE A  94
 None
 1.02A 1tw4A-2iueA:
undetectable		 1tw4A-2iueA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		5 LEU A 108
LEU A 110
LEU A 160
ILE A  94
ILE A  48
 None
 1.02A 1tw4A-2iueA:
undetectable		 1tw4A-2iueA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 LEU A 426
LEU A 425
ALA A 438
ILE A 409
ILE A 483
 None
 1.14A 1tw4A-2nrxA:
undetectable		 1tw4A-2nrxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 LEU A 225
LEU A 222
ILE A 320
ILE A 393
LEU A 397
 None
 0.91A 1tw4A-2nxxA:
undetectable		 1tw4A-2nxxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 LEU A 398
ALA A 541
ILE A 356
ILE A 391
LEU A 405
 None
 1.04A 1tw4A-2o2cA:
undetectable		 1tw4A-2o2cA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 757
LEU A 749
ILE A 244
THR A 122
ILE A 761
 None
 0.93A 1tw4A-2pi5A:
undetectable		 1tw4A-2pi5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1d 2-KETO-3-DEOXY-D-ARA
BINONATE DEHYDRATASE

(Sulfolobus
solfataricus) 		PF01557
(FAA_hydrolase) 		5 LEU X  57
LEU X  56
ILE X 279
THR X 160
ILE X  23
 None
 1.15A 1tw4A-2q1dX:
undetectable		 1tw4A-2q1dX:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		5 LEU A 172
ALA A 171
ILE A 148
LEU A 157
ARG A 159
 None
 1.14A 1tw4A-2qnuA:
undetectable		 1tw4A-2qnuA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 LEU A  18
ALA A  31
ASP A  74
HIS A  98
ARG A 120
 CHD  A 130 ( 4.7A)
CHD  A 130 ( 3.8A)
GOL  A 145 ( 2.8A)
IPA  A 140 (-3.7A)
CHD  A 130 (-3.4A)
 0.69A 1tw4A-2qo4A:
21.6		 1tw4A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ran ANNEXIN V

(Rattus
norvegicus) 		PF00191
(Annexin) 		5 ALA A 237
THR A 252
ILE A 123
LEU A 120
ARG A 115
 None
 1.03A 1tw4A-2ranA:
undetectable		 1tw4A-2ranA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct) 		PF00514
(Arm)
PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU B 144
LEU A 106
ALA B 150
ILE B 154
LEU B 174
 None
 1.09A 1tw4A-2ru4B:
undetectable		 1tw4A-2ru4B:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 LEU A  47
ALA A  53
ILE A  56
ILE A  38
LEU A  35
 None
 1.08A 1tw4A-2wzfA:
undetectable		 1tw4A-2wzfA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 LEU A 426
ALA A 429
ILE A 433
ILE A 248
LEU A 253
 None
 1.14A 1tw4A-2xydA:
undetectable		 1tw4A-2xydA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
ALA A 510
ILE A 388
HIS A 424
ILE A 461
 None
CSO  A 509 (-3.8A)
GOL  A 902 (-3.5A)
None
None
 0.90A 1tw4A-2z2wA:
undetectable		 1tw4A-2z2wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4r NFATC2-INTERACTING
PROTEIN

(Mus musculus) 		PF11976
(Rad60-SLD) 		5 LEU A  -2
ALA A 398
ASP A 361
ILE A 356
LEU A 343
 None
 0.97A 1tw4A-3a4rA:
undetectable		 1tw4A-3a4rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0c CENTROMERE PROTEIN W

(Gallus gallus) 		PF15510
(CENP-W) 		5 LEU W  42
LEU W  39
LEU W  71
ALA W  67
ILE W  64
 None
 1.10A 1tw4A-3b0cW:
undetectable		 1tw4A-3b0cW:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq7 DIACYLGLYCEROL
KINASE DELTA

(Homo sapiens) 		PF07647
(SAM_2) 		5 LEU A  14
LEU A  17
ILE A  25
ILE A  62
LEU A  36
 None
 1.12A 1tw4A-3bq7A:
undetectable		 1tw4A-3bq7A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		5 LEU A  66
ALA A  30
ILE A 252
THR A 255
ASP A  25
 None
 1.05A 1tw4A-3dxiA:
undetectable		 1tw4A-3dxiA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		5 LEU A  66
LEU A  29
ILE A 252
THR A 255
ASP A  25
 None
 1.15A 1tw4A-3dxiA:
undetectable		 1tw4A-3dxiA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 135
ALA A 272
ASP A 141
ILE A 109
LEU A 105
 None
 1.15A 1tw4A-3glbA:
undetectable		 1tw4A-3glbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		5 LEU A 244
LEU A 178
LEU A 265
ILE A 309
ARG A 172
 None
 1.09A 1tw4A-3grzA:
undetectable		 1tw4A-3grzA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il0 AMINOPEPTIDASE P
XAA-PRO
AMINOPEPTIDASE

(Streptococcus
thermophilus) 		PF01321
(Creatinase_N) 		5 LEU A  88
ALA A  19
ASP A  86
ILE A  70
LEU A  51
 None
 1.00A 1tw4A-3il0A:
undetectable		 1tw4A-3il0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		5 LEU A 206
LEU A 182
ALA A 199
THR A 272
ILE A 242
 None
 1.13A 1tw4A-3innA:
undetectable		 1tw4A-3innA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 LEU A 311
LEU A 275
ALA A 278
ILE A 426
LEU A 399
 None
 1.05A 1tw4A-3iwjA:
undetectable		 1tw4A-3iwjA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A  65
LEU A  59
ALA A  43
HIS A  77
ILE A  78
 None
 1.09A 1tw4A-3kb6A:
undetectable		 1tw4A-3kb6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 LEU A 153
LEU A 149
ILE A 125
HIS A 187
LEU A 206
 None
 1.13A 1tw4A-3krsA:
undetectable		 1tw4A-3krsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 LEU A 440
LEU A 443
LEU A 462
ALA A 485
ILE A 288
 None
 1.13A 1tw4A-3m8uA:
undetectable		 1tw4A-3m8uA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 190
LEU A 193
LEU A 229
ILE A 152
LEU A 149
 None
 1.10A 1tw4A-3mqtA:
undetectable		 1tw4A-3mqtA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
mutans) 		PF00440
(TetR_N) 		5 LEU A  78
LEU A  32
ALA A  35
ILE A  52
ILE A 136
 None
 1.13A 1tw4A-3mvpA:
undetectable		 1tw4A-3mvpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		5 LEU A 365
LEU A 139
ALA A 359
ILE A 354
ILE A 334
 None
 1.15A 1tw4A-3n9xA:
undetectable		 1tw4A-3n9xA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A 370
LEU A 141
ALA A 364
ILE A 359
ILE A 339
 None
 1.02A 1tw4A-3nieA:
undetectable		 1tw4A-3nieA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		5 LEU A 561
LEU A 558
LEU A 475
ILE A 316
HIS A 306
 None
 1.11A 1tw4A-3o0yA:
undetectable		 1tw4A-3o0yA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 5 LEU L 239
ALA L 242
ILE L 154
MET L 258
ILE L  99
 None
 1.01A 1tw4A-3rkoL:
undetectable		 1tw4A-3rkoL:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		5 LEU A 108
LEU A 105
ILE A  68
ILE A 132
LEU A 129
 None
 0.87A 1tw4A-3s51A:
undetectable		 1tw4A-3s51A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3

(Homo sapiens) 		PF00617
(RasGEF) 		5 LEU A 811
LEU A 815
ILE A 613
THR A 626
LEU A 532
 None
 1.13A 1tw4A-3t6aA:
undetectable		 1tw4A-3t6aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.06A 1tw4A-3tcqA:
undetectable		 1tw4A-3tcqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 LEU A  43
LEU A  45
LEU A  75
ALA A  15
ILE A  14
 None
 1.14A 1tw4A-3tm5A:
undetectable		 1tw4A-3tm5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tri PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Coxiella
burnetii) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 LEU A  93
LEU A  87
ALA A  61
THR A  35
ILE A 151
 None
 1.11A 1tw4A-3triA:
undetectable		 1tw4A-3triA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		5 LEU A 432
ALA A 238
ILE A 217
ILE A 415
LEU A 418
 None
 1.14A 1tw4A-3vxcA:
undetectable		 1tw4A-3vxcA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 LEU A  43
LEU A 157
ALA A 114
ILE A 115
ILE A  55
 None
 1.01A 1tw4A-3wajA:
undetectable		 1tw4A-3wajA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 LEU A  95
LEU A  92
ILE A  45
THR A  24
ILE A 161
 None
 1.14A 1tw4A-3zizA:
undetectable		 1tw4A-3zizA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuh PROTEIN CBBX

(Rhodobacter
sphaeroides) 		PF00004
(AAA) 		5 LEU A 142
ALA A 155
ILE A 158
ASP A 109
LEU A 174
 None
 0.95A 1tw4A-3zuhA:
undetectable		 1tw4A-3zuhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE

(Corynebacterium
efficiens) 		PF00977
(His_biosynth) 		6 LEU A 158
LEU A 155
LEU A 107
ALA A 106
ILE A 102
ILE A 196
 None
 1.29A 1tw4A-4axkA:
undetectable		 1tw4A-4axkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 5 LEU A 396
LEU A 423
ILE A 456
ILE A 513
LEU A 509
 None
 1.09A 1tw4A-4bwkA:
undetectable		 1tw4A-4bwkA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		5 LEU A 499
LEU A 451
ALA A 470
ILE A 484
ILE A 529
 None
MC3  A 603 ( 3.5A)
None
None
None
 1.14A 1tw4A-4c00A:
2.1		 1tw4A-4c00A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfi FLAGELLIN

(Burkholderia
pseudomallei) 		PF00669
(Flagellin_N)
PF12613
(FliC_SP) 		5 LEU A  81
LEU A 319
ALA A  77
ILE A 136
ILE A 169
 None
 1.06A 1tw4A-4cfiA:
undetectable		 1tw4A-4cfiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		5 LEU B 183
LEU B 232
ILE B 249
THR B 247
ILE B 156
 None
 1.15A 1tw4A-4cv5B:
undetectable		 1tw4A-4cv5B:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 758
ILE A 790
ASP A 815
HIS A 467
ILE A 470
 None
 1.05A 1tw4A-4f9oA:
undetectable		 1tw4A-4f9oA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		5 LEU A   9
ILE A 137
THR A 139
ILE A  92
LEU A  96
 None
 1.07A 1tw4A-4jjpA:
undetectable		 1tw4A-4jjpA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc3 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1

(Homo sapiens;
Homo sapiens) 		PF15095
(IL33)
PF07679
(I-set) 		5 LEU A 220
LEU B 308
LEU A 161
ILE A 240
HIS A 224
 None
 1.15A 1tw4A-4kc3A:
undetectable		 1tw4A-4kc3A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.07A 1tw4A-4ld8A:
undetectable		 1tw4A-4ld8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		5 LEU D  93
ALA D  92
ILE D  85
ILE D 165
LEU D 166
 None
 0.98A 1tw4A-4mwaD:
undetectable		 1tw4A-4mwaD:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxp RIBONUCLEASE E

(Caulobacter
vibrioides) 		PF10150
(RNase_E_G) 		5 LEU A 179
LEU A 186
LEU A 177
ILE A 265
THR A 256
 None
 0.95A 1tw4A-4oxpA:
undetectable		 1tw4A-4oxpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		5 LEU U 212
LEU U 209
ILE U 307
ILE U 380
LEU U 384
 None
 0.86A 1tw4A-4oztU:
undetectable		 1tw4A-4oztU:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 LEU A  23
LEU A  20
ALA A  81
ILE A  82
THR A 166
 None
 0.96A 1tw4A-4q38A:
undetectable		 1tw4A-4q38A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 LEU A 303
LEU A 328
HIS A 262
ILE A 315
LEU A 316
 None
EDO  A 411 ( 4.5A)
None
None
None
 1.14A 1tw4A-4rgqA:
undetectable		 1tw4A-4rgqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  55
ALA A  46
ILE A  45
HIS A 247
LEU A 285
 None
 1.08A 1tw4A-4rybA:
0.6		 1tw4A-4rybA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A  89
LEU A  25
THR A  56
MET A  63
ILE A  75
 None
 1.10A 1tw4A-4x4wA:
undetectable		 1tw4A-4x4wA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdi CHLAMYDOMONAS
REINHARDTII THB1

(Chlamydomonas
reinhardtii) 		PF01152
(Bac_globin) 		5 LEU A 102
LEU A 105
LEU A 111
ALA A 115
ILE A 118
 None
 0.84A 1tw4A-4xdiA:
undetectable		 1tw4A-4xdiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsy RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		5 LEU F 598
LEU F 607
LEU F 595
ALA F 594
HIS F 545
 None
 1.10A 1tw4A-4xsyF:
undetectable		 1tw4A-4xsyF:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Methanocaldococcus
jannaschii;
Methanocaldococcus
jannaschii) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 LEU B  30
LEU B  55
ILE A  15
THR A   7
ILE B  41
 None
 1.13A 1tw4A-4zn1B:
undetectable		 1tw4A-4zn1B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A 231
ILE A 212
THR A 210
ILE A  54
LEU A  53
 None
 1.12A 1tw4A-5a22A:
undetectable		 1tw4A-5a22A:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 363
LEU A 342
LEU A 390
ALA A 361
ILE A 273
 None
 1.14A 1tw4A-5ah4A:
1.1		 1tw4A-5ah4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  37
ALA A  12
ASP A   5
ILE A 166
LEU A  98
 None
 1.08A 1tw4A-5ahkA:
undetectable		 1tw4A-5ahkA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii) 		PF08652
(RAI1) 		5 LEU A 264
LEU A 260
ILE A 309
ILE A 102
LEU A 210
 None
 1.12A 1tw4A-5btbA:
undetectable		 1tw4A-5btbA:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 LEU A  24
ALA A  34
THR A  57
ASP A  77
ILE A 105
 None
 0.92A 1tw4A-5bvqA:
18.5		 1tw4A-5bvqA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cq9 SECRETED EFFECTOR
PROTEIN SOPD2

(Salmonella
enterica) 		PF11047
(SopD) 		5 LEU A 127
LEU A 124
THR A  85
MET A 101
LEU A 253
 None
 1.11A 1tw4A-5cq9A:
undetectable		 1tw4A-5cq9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		6 LEU a 108
LEU a 532
LEU a 455
ALA a 454
ILE a 126
LEU a 539
 None
 1.37A 1tw4A-5gw5a:
undetectable		 1tw4A-5gw5a:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 681
LEU A 678
ILE A 476
THR A 208
LEU A 505
 None
 1.09A 1tw4A-5i4eA:
undetectable		 1tw4A-5i4eA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjx SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 5 LEU A 101
LEU A 105
ILE A 119
ASP A 111
ARG A 120
 None
 1.12A 1tw4A-5jjxA:
undetectable		 1tw4A-5jjxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vho 26S PROTEASOME
REGULATORY SUBUNIT
6B

(Homo sapiens) 		PF00004
(AAA) 		5 LEU D 321
LEU D 327
LEU D 317
ALA D 271
ILE D 270
 None
 1.10A 1tw4A-5vhoD:
undetectable		 1tw4A-5vhoD:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU C2299
ALA C2094
ILE C2116
ILE C2219
LEU C2220
 None
 1.14A 1tw4A-5x6oC:
undetectable		 1tw4A-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A 421
ALA A 253
ILE A 256
THR A 322
ILE A 404
 None
 0.95A 1tw4A-5xwbA:
undetectable		 1tw4A-5xwbA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 5 LEU A 437
LEU A 424
ALA A  81
ILE A 100
ASP A 430
 None
 1.03A 1tw4A-5xwqA:
undetectable		 1tw4A-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 LEU A 746
LEU A 747
ALA A 710
HIS A 774
ILE A 775
 None
 1.11A 1tw4A-5y4fA:
undetectable		 1tw4A-5y4fA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 LEU A1545
ALA A1311
HIS A1655
ILE A1656
LEU A1659
 None
 1.11A 1tw4A-6b3rA:
undetectable		 1tw4A-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 5 LEU E 364
LEU E 367
LEU E  82
ILE E  89
LEU E1260
 None
 1.02A 1tw4A-6c3pE:
undetectable		 1tw4A-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU A 214
LEU A 213
LEU A 151
ALA A 154
ILE A 200
 None
 1.05A 1tw4A-6c54A:
undetectable		 1tw4A-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 5 LEU L 233
ALA L 236
ILE L 155
MET L 252
ILE L 100
 None
 1.08A 1tw4A-6g2jL:
undetectable		 1tw4A-6g2jL:
undetectable