SIMILAR PATTERNS OF AMINO ACIDS FOR 1TW4_A_CHDA130

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		5 LEU A 193
LEU A 190
LEU A 152
ILE A 142
LEU A 207
 None
 1.03A 1tw4A-1alqA:
undetectable		 1tw4A-1alqA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 ALA A 171
ILE A 116
ASP A 106
ILE A 189
LEU A 193
 None
 1.12A 1tw4A-1eb3A:
undetectable		 1tw4A-1eb3A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.09A 1tw4A-1es6A:
0.7		 1tw4A-1es6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 371
LEU A 203
ALA A 336
ILE A 335
ILE A  76
 None
 1.07A 1tw4A-1fnoA:
undetectable		 1tw4A-1fnoA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 LEU A 128
LEU A  49
ALA A  57
ILE A  60
LEU A  81
 None
None
None
None
HEC  A 601 (-4.7A)
 1.01A 1tw4A-1gq1A:
0.7		 1tw4A-1gq1A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		5 LEU A 167
LEU A 164
ALA A 139
ILE A 142
ILE A 178
 None
 1.12A 1tw4A-1losA:
undetectable		 1tw4A-1losA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		7 LEU A  18
ALA A  31
THR A  53
HIS A  98
ILE A 111
LEU A 118
ARG A 120
 None
 0.80A 1tw4A-1p6pA:
19.9		 1tw4A-1p6pA:
66.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 639
ALA A 695
ILE A 694
ILE A 556
LEU A 453
 None
 1.13A 1tw4A-1r8wA:
0.0		 1tw4A-1r8wA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 LEU A 248
LEU A 252
ALA A 243
ILE A 176
LEU A 170
 None
 1.11A 1tw4A-1sqhA:
undetectable		 1tw4A-1sqhA:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		5 LEU A  23
ILE A  34
THR A  53
LEU A 118
ARG A 120
 None
 0.74A 1tw4A-1zryA:
12.4		 1tw4A-1zryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		5 LEU A 248
LEU A 247
ILE A 199
MET A 218
ARG A 210
 None
 1.07A 1tw4A-2a5hA:
undetectable		 1tw4A-2a5hA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8i PAS FACTOR

(Vibrio
vulnificus) 		PF09016
(Pas_Saposin) 		5 LEU A  13
LEU A  16
LEU A  58
ALA A  67
LEU A  31
 None
 0.94A 1tw4A-2b8iA:
undetectable		 1tw4A-2b8iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 317
ILE A 346
THR A 348
ILE A 400
LEU A 418
 None
 0.99A 1tw4A-2bv5A:
0.6		 1tw4A-2bv5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 235
LEU A 234
LEU A 247
ALA A 255
ASP A 263
 None
 1.10A 1tw4A-2ctzA:
undetectable		 1tw4A-2ctzA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 235
LEU A 234
LEU A 247
ILE A 257
ASP A 263
 None
 1.01A 1tw4A-2ctzA:
undetectable		 1tw4A-2ctzA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei9 NON-LTR
RETROTRANSPOSON
R1BMKS ORF2 PROTEIN

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		5 LEU A 113
LEU A 110
ALA A  98
ILE A 163
LEU A 168
 None
 1.08A 1tw4A-2ei9A:
undetectable		 1tw4A-2ei9A:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		7 LEU A  18
ALA A  31
ILE A  34
THR A  53
HIS A  98
LEU A 118
ARG A 120
 None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
None
 0.58A 1tw4A-2ftbA:
22.7		 1tw4A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 933
LEU A 977
ALA A 987
ILE A 883
LEU A 893
 None
 1.09A 1tw4A-2gv9A:
undetectable		 1tw4A-2gv9A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hd3 ETHANOLAMINE
UTILIZATION PROTEIN
EUTN

(Escherichia
coli) 		PF03319
(EutN_CcmL) 		5 LEU A  25
LEU A  24
ALA A  49
ILE A  81
LEU A  76
 None
 1.13A 1tw4A-2hd3A:
undetectable		 1tw4A-2hd3A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		6 LEU A  56
ALA A  83
ILE A 118
HIS A 103
ILE A 104
LEU A  91
 None
 1.06A 1tw4A-2hhzA:
1.7		 1tw4A-2hhzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 218
LEU A 215
ILE A 171
HIS A 238
ILE A 250
 None
 0.94A 1tw4A-2hzgA:
undetectable		 1tw4A-2hzgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		5 LEU A 108
LEU A 110
LEU A 160
ALA A  93
ILE A  94
 None
 1.02A 1tw4A-2iueA:
undetectable		 1tw4A-2iueA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		5 LEU A 108
LEU A 110
LEU A 160
ILE A  94
ILE A  48
 None
 1.02A 1tw4A-2iueA:
undetectable		 1tw4A-2iueA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 LEU A 426
LEU A 425
ALA A 438
ILE A 409
ILE A 483
 None
 1.14A 1tw4A-2nrxA:
undetectable		 1tw4A-2nrxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 LEU A 225
LEU A 222
ILE A 320
ILE A 393
LEU A 397
 None
 0.91A 1tw4A-2nxxA:
undetectable		 1tw4A-2nxxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 LEU A 398
ALA A 541
ILE A 356
ILE A 391
LEU A 405
 None
 1.04A 1tw4A-2o2cA:
undetectable		 1tw4A-2o2cA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 757
LEU A 749
ILE A 244
THR A 122
ILE A 761
 None
 0.93A 1tw4A-2pi5A:
undetectable		 1tw4A-2pi5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1d 2-KETO-3-DEOXY-D-ARA
BINONATE DEHYDRATASE

(Sulfolobus
solfataricus) 		PF01557
(FAA_hydrolase) 		5 LEU X  57
LEU X  56
ILE X 279
THR X 160
ILE X  23
 None
 1.15A 1tw4A-2q1dX:
undetectable		 1tw4A-2q1dX:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		5 LEU A 172
ALA A 171
ILE A 148
LEU A 157
ARG A 159
 None
 1.14A 1tw4A-2qnuA:
undetectable		 1tw4A-2qnuA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 LEU A  18
ALA A  31
ASP A  74
HIS A  98
ARG A 120
 CHD  A 130 ( 4.7A)
CHD  A 130 ( 3.8A)
GOL  A 145 ( 2.8A)
IPA  A 140 (-3.7A)
CHD  A 130 (-3.4A)
 0.69A 1tw4A-2qo4A:
21.6		 1tw4A-2qo4A:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ran ANNEXIN V

(Rattus
norvegicus) 		PF00191
(Annexin) 		5 ALA A 237
THR A 252
ILE A 123
LEU A 120
ARG A 115
 None
 1.03A 1tw4A-2ranA:
undetectable		 1tw4A-2ranA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct) 		PF00514
(Arm)
PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU B 144
LEU A 106
ALA B 150
ILE B 154
LEU B 174
 None
 1.09A 1tw4A-2ru4B:
undetectable		 1tw4A-2ru4B:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 LEU A  47
ALA A  53
ILE A  56
ILE A  38
LEU A  35
 None
 1.08A 1tw4A-2wzfA:
undetectable		 1tw4A-2wzfA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 LEU A 426
ALA A 429
ILE A 433
ILE A 248
LEU A 253
 None
 1.14A 1tw4A-2xydA:
undetectable		 1tw4A-2xydA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
ALA A 510
ILE A 388
HIS A 424
ILE A 461
 None
CSO  A 509 (-3.8A)
GOL  A 902 (-3.5A)
None
None
 0.90A 1tw4A-2z2wA:
undetectable		 1tw4A-2z2wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4r NFATC2-INTERACTING
PROTEIN

(Mus musculus) 		PF11976
(Rad60-SLD) 		5 LEU A  -2
ALA A 398
ASP A 361
ILE A 356
LEU A 343
 None
 0.97A 1tw4A-3a4rA:
undetectable		 1tw4A-3a4rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0c CENTROMERE PROTEIN W

(Gallus gallus) 		PF15510
(CENP-W) 		5 LEU W  42
LEU W  39
LEU W  71
ALA W  67
ILE W  64
 None
 1.10A 1tw4A-3b0cW:
undetectable		 1tw4A-3b0cW:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq7 DIACYLGLYCEROL
KINASE DELTA

(Homo sapiens) 		PF07647
(SAM_2) 		5 LEU A  14
LEU A  17
ILE A  25
ILE A  62
LEU A  36
 None
 1.12A 1tw4A-3bq7A:
undetectable		 1tw4A-3bq7A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		5 LEU A  66
ALA A  30
ILE A 252
THR A 255
ASP A  25
 None
 1.05A 1tw4A-3dxiA:
undetectable		 1tw4A-3dxiA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		5 LEU A  66
LEU A  29
ILE A 252
THR A 255
ASP A  25
 None
 1.15A 1tw4A-3dxiA:
undetectable		 1tw4A-3dxiA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 135
ALA A 272
ASP A 141
ILE A 109
LEU A 105
 None
 1.15A 1tw4A-3glbA:
undetectable		 1tw4A-3glbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		5 LEU A 244
LEU A 178
LEU A 265
ILE A 309
ARG A 172
 None
 1.09A 1tw4A-3grzA:
undetectable		 1tw4A-3grzA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il0 AMINOPEPTIDASE P
XAA-PRO
AMINOPEPTIDASE

(Streptococcus
thermophilus) 		PF01321
(Creatinase_N) 		5 LEU A  88
ALA A  19
ASP A  86
ILE A  70
LEU A  51
 None
 1.00A 1tw4A-3il0A:
undetectable		 1tw4A-3il0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		5 LEU A 206
LEU A 182
ALA A 199
THR A 272
ILE A 242
 None
 1.13A 1tw4A-3innA:
undetectable		 1tw4A-3innA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 LEU A 311
LEU A 275
ALA A 278
ILE A 426
LEU A 399
 None
 1.05A 1tw4A-3iwjA:
undetectable		 1tw4A-3iwjA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A  65
LEU A  59
ALA A  43
HIS A  77
ILE A  78
 None
 1.09A 1tw4A-3kb6A:
undetectable		 1tw4A-3kb6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 LEU A 153
LEU A 149
ILE A 125
HIS A 187
LEU A 206
 None
 1.13A 1tw4A-3krsA:
undetectable		 1tw4A-3krsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 LEU A 440
LEU A 443
LEU A 462
ALA A 485
ILE A 288
 None
 1.13A 1tw4A-3m8uA:
undetectable		 1tw4A-3m8uA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 190
LEU A 193
LEU A 229
ILE A 152
LEU A 149
 None
 1.10A 1tw4A-3mqtA:
undetectable		 1tw4A-3mqtA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
mutans) 		PF00440
(TetR_N) 		5 LEU A  78
LEU A  32
ALA A  35
ILE A  52
ILE A 136
 None
 1.13A 1tw4A-3mvpA:
undetectable		 1tw4A-3mvpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		5 LEU A 365
LEU A 139
ALA A 359
ILE A 354
ILE A 334
 None
 1.15A 1tw4A-3n9xA:
undetectable		 1tw4A-3n9xA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A 370
LEU A 141
ALA A 364
ILE A 359
ILE A 339
 None
 1.02A 1tw4A-3nieA:
undetectable		 1tw4A-3nieA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		5 LEU A 561
LEU A 558
LEU A 475
ILE A 316
HIS A 306
 None
 1.11A 1tw4A-3o0yA:
undetectable		 1tw4A-3o0yA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 5 LEU L 239
ALA L 242
ILE L 154
MET L 258
ILE L  99
 None
 1.01A 1tw4A-3rkoL:
undetectable		 1tw4A-3rkoL:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		5 LEU A 108
LEU A 105
ILE A  68
ILE A 132
LEU A 129
 None
 0.87A 1tw4A-3s51A:
undetectable		 1tw4A-3s51A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3

(Homo sapiens) 		PF00617
(RasGEF) 		5 LEU A 811
LEU A 815
ILE A 613
THR A 626
LEU A 532
 None
 1.13A 1tw4A-3t6aA:
undetectable		 1tw4A-3t6aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.06A 1tw4A-3tcqA:
undetectable		 1tw4A-3tcqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 LEU A  43
LEU A  45
LEU A  75
ALA A  15
ILE A  14
 None
 1.14A 1tw4A-3tm5A:
undetectable		 1tw4A-3tm5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tri PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Coxiella
burnetii) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 LEU A  93
LEU A  87
ALA A  61
THR A  35
ILE A 151
 None
 1.11A 1tw4A-3triA:
undetectable		 1tw4A-3triA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		5 LEU A 432
ALA A 238
ILE A 217
ILE A 415
LEU A 418
 None
 1.14A 1tw4A-3vxcA:
undetectable		 1tw4A-3vxcA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 LEU A  43
LEU A 157
ALA A 114
ILE A 115
ILE A  55
 None
 1.01A 1tw4A-3wajA:
undetectable		 1tw4A-3wajA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 LEU A  95
LEU A  92
ILE A  45
THR A  24
ILE A 161
 None
 1.14A 1tw4A-3zizA:
undetectable		 1tw4A-3zizA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuh PROTEIN CBBX

(Rhodobacter
sphaeroides) 		PF00004
(AAA) 		5 LEU A 142
ALA A 155
ILE A 158
ASP A 109
LEU A 174
 None
 0.95A 1tw4A-3zuhA:
undetectable		 1tw4A-3zuhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE

(Corynebacterium
efficiens) 		PF00977
(His_biosynth) 		6 LEU A 158
LEU A 155
LEU A 107
ALA A 106
ILE A 102
ILE A 196
 None
 1.29A 1tw4A-4axkA:
undetectable		 1tw4A-4axkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 5 LEU A 396
LEU A 423
ILE A 456
ILE A 513
LEU A 509
 None
 1.09A 1tw4A-4bwkA:
undetectable		 1tw4A-4bwkA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		5 LEU A 499
LEU A 451
ALA A 470
ILE A 484
ILE A 529
 None
MC3  A 603 ( 3.5A)
None
None
None
 1.14A 1tw4A-4c00A:
2.1		 1tw4A-4c00A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfi FLAGELLIN

(Burkholderia
pseudomallei) 		PF00669
(Flagellin_N)
PF12613
(FliC_SP) 		5 LEU A  81
LEU A 319
ALA A  77
ILE A 136
ILE A 169
 None
 1.06A 1tw4A-4cfiA:
undetectable		 1tw4A-4cfiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		5 LEU B 183
LEU B 232
ILE B 249
THR B 247
ILE B 156
 None
 1.15A 1tw4A-4cv5B:
undetectable		 1tw4A-4cv5B:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 758
ILE A 790
ASP A 815
HIS A 467
ILE A 470
 None
 1.05A 1tw4A-4f9oA:
undetectable		 1tw4A-4f9oA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		5 LEU A   9
ILE A 137
THR A 139
ILE A  92
LEU A  96
 None
 1.07A 1tw4A-4jjpA:
undetectable		 1tw4A-4jjpA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc3 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1

(Homo sapiens;
Homo sapiens) 		PF15095
(IL33)
PF07679
(I-set) 		5 LEU A 220
LEU B 308
LEU A 161
ILE A 240
HIS A 224
 None
 1.15A 1tw4A-4kc3A:
undetectable		 1tw4A-4kc3A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.07A 1tw4A-4ld8A:
undetectable		 1tw4A-4ld8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		5 LEU D  93
ALA D  92
ILE D  85
ILE D 165
LEU D 166
 None
 0.98A 1tw4A-4mwaD:
undetectable		 1tw4A-4mwaD:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxp RIBONUCLEASE E

(Caulobacter
vibrioides) 		PF10150
(RNase_E_G) 		5 LEU A 179
LEU A 186
LEU A 177
ILE A 265
THR A 256
 None
 0.95A 1tw4A-4oxpA:
undetectable		 1tw4A-4oxpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		5 LEU U 212
LEU U 209
ILE U 307
ILE U 380
LEU U 384
 None
 0.86A 1tw4A-4oztU:
undetectable		 1tw4A-4oztU:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 LEU A  23
LEU A  20
ALA A  81
ILE A  82
THR A 166
 None
 0.96A 1tw4A-4q38A:
undetectable		 1tw4A-4q38A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 LEU A 303
LEU A 328
HIS A 262
ILE A 315
LEU A 316
 None
EDO  A 411 ( 4.5A)
None
None
None
 1.14A 1tw4A-4rgqA:
undetectable		 1tw4A-4rgqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  55
ALA A  46
ILE A  45
HIS A 247
LEU A 285
 None
 1.08A 1tw4A-4rybA:
0.6		 1tw4A-4rybA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A  89
LEU A  25
THR A  56
MET A  63
ILE A  75
 None
 1.10A 1tw4A-4x4wA:
undetectable		 1tw4A-4x4wA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdi CHLAMYDOMONAS
REINHARDTII THB1

(Chlamydomonas
reinhardtii) 		PF01152
(Bac_globin) 		5 LEU A 102
LEU A 105
LEU A 111
ALA A 115
ILE A 118
 None
 0.84A 1tw4A-4xdiA:
undetectable		 1tw4A-4xdiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsy RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		5 LEU F 598
LEU F 607
LEU F 595
ALA F 594
HIS F 545
 None
 1.10A 1tw4A-4xsyF:
undetectable		 1tw4A-4xsyF:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Methanocaldococcus
jannaschii;
Methanocaldococcus
jannaschii) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 LEU B  30
LEU B  55
ILE A  15
THR A   7
ILE B  41
 None
 1.13A 1tw4A-4zn1B:
undetectable		 1tw4A-4zn1B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A 231
ILE A 212
THR A 210
ILE A  54
LEU A  53
 None
 1.12A 1tw4A-5a22A:
undetectable		 1tw4A-5a22A:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 363
LEU A 342
LEU A 390
ALA A 361
ILE A 273
 None
 1.14A 1tw4A-5ah4A:
1.1		 1tw4A-5ah4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  37
ALA A  12
ASP A   5
ILE A 166
LEU A  98
 None
 1.08A 1tw4A-5ahkA:
undetectable		 1tw4A-5ahkA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii) 		PF08652
(RAI1) 		5 LEU A 264
LEU A 260
ILE A 309
ILE A 102
LEU A 210
 None
 1.12A 1tw4A-5btbA:
undetectable		 1tw4A-5btbA:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 LEU A  24
ALA A  34
THR A  57
ASP A  77
ILE A 105
 None
 0.92A 1tw4A-5bvqA:
18.5		 1tw4A-5bvqA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cq9 SECRETED EFFECTOR
PROTEIN SOPD2

(Salmonella
enterica) 		PF11047
(SopD) 		5 LEU A 127
LEU A 124
THR A  85
MET A 101
LEU A 253
 None
 1.11A 1tw4A-5cq9A:
undetectable		 1tw4A-5cq9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		6 LEU a 108
LEU a 532
LEU a 455
ALA a 454
ILE a 126
LEU a 539
 None
 1.37A 1tw4A-5gw5a:
undetectable		 1tw4A-5gw5a:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 681
LEU A 678
ILE A 476
THR A 208
LEU A 505
 None
 1.09A 1tw4A-5i4eA:
undetectable		 1tw4A-5i4eA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjx SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 5 LEU A 101
LEU A 105
ILE A 119
ASP A 111
ARG A 120
 None
 1.12A 1tw4A-5jjxA:
undetectable		 1tw4A-5jjxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vho 26S PROTEASOME
REGULATORY SUBUNIT
6B

(Homo sapiens) 		PF00004
(AAA) 		5 LEU D 321
LEU D 327
LEU D 317
ALA D 271
ILE D 270
 None
 1.10A 1tw4A-5vhoD:
undetectable		 1tw4A-5vhoD:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU C2299
ALA C2094
ILE C2116
ILE C2219
LEU C2220
 None
 1.14A 1tw4A-5x6oC:
undetectable		 1tw4A-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A 421
ALA A 253
ILE A 256
THR A 322
ILE A 404
 None
 0.95A 1tw4A-5xwbA:
undetectable		 1tw4A-5xwbA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 5 LEU A 437
LEU A 424
ALA A  81
ILE A 100
ASP A 430
 None
 1.03A 1tw4A-5xwqA:
undetectable		 1tw4A-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 LEU A 746
LEU A 747
ALA A 710
HIS A 774
ILE A 775
 None
 1.11A 1tw4A-5y4fA:
undetectable		 1tw4A-5y4fA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 LEU A1545
ALA A1311
HIS A1655
ILE A1656
LEU A1659
 None
 1.11A 1tw4A-6b3rA:
undetectable		 1tw4A-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 5 LEU E 364
LEU E 367
LEU E  82
ILE E  89
LEU E1260
 None
 1.02A 1tw4A-6c3pE:
undetectable		 1tw4A-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU A 214
LEU A 213
LEU A 151
ALA A 154
ILE A 200
 None
 1.05A 1tw4A-6c54A:
undetectable		 1tw4A-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 5 LEU L 233
ALA L 236
ILE L 155
MET L 252
ILE L 100
 None
 1.08A 1tw4A-6g2jL:
undetectable		 1tw4A-6g2jL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 TYR A 594
ARG A 533
GLN A 529
 None
 0.83A 1tw4A-1ddgA:
0.0		 1tw4A-1ddgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 491
ARG C 245
GLN A 454
 None
 1.03A 1tw4A-1e6vA:
0.0		 1tw4A-1e6vA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 TYR B2215
ARG B2041
GLN B2112
 None
 0.65A 1tw4A-1e6yB:
0.0		 1tw4A-1e6yB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A1508
ARG C3240
GLN A1471
 None
 0.95A 1tw4A-1e6yA:
0.0		 1tw4A-1e6yA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		3 TYR A 328
ARG A 189
GLN A 185
 None
 0.96A 1tw4A-1l5aA:
0.0		 1tw4A-1l5aA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF01074
(Glyco_hydro_38)
PF09261
(Alpha-mann_mid) 		3 TYR B 359
ARG A 229
GLN A 234
 None
 0.94A 1tw4A-1o7dB:
undetectable		 1tw4A-1o7dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 TYR A 188
ARG A  86
GLN A  81
 None
 1.02A 1tw4A-1ofeA:
3.6		 1tw4A-1ofeA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi1 SCML2 PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		3 TYR A 215
ARG A 222
GLN A  54
 None
 0.96A 1tw4A-1oi1A:
undetectable		 1tw4A-1oi1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR A 278
ARG A 249
GLN A 247
 None
 1.00A 1tw4A-1pd1A:
undetectable		 1tw4A-1pd1A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		3 TYR A 355
ARG A 363
GLN A 360
 None
 0.87A 1tw4A-1slqA:
1.3		 1tw4A-1slqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 TYR A 137
ARG A 167
GLN A 164
 None
 1.01A 1tw4A-1t1uA:
undetectable		 1tw4A-1t1uA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 TYR A 696
ARG A 617
GLN A 613
 None
 1.00A 1tw4A-1taqA:
undetectable		 1tw4A-1taqA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TYR A 115
ARG A  48
GLN A  44
 None
 1.00A 1tw4A-1ukwA:
undetectable		 1tw4A-1ukwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 TYR A 649
ARG A 632
GLN A 690
 None
 1.00A 1tw4A-1zcjA:
undetectable		 1tw4A-1zcjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		3 TYR A 235
ARG A 208
GLN A 142
 None
ADP  A 500 (-4.3A)
None
 0.95A 1tw4A-2bejA:
undetectable		 1tw4A-2bejA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN

(Mycoplasma
arthritidis) 		PF09245
(MA-Mit) 		3 TYR G  33
ARG G  57
GLN G  54
 None
 0.96A 1tw4A-2icwG:
undetectable		 1tw4A-2icwG:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 116
ARG A 126
GLN A 127
 None
 0.98A 1tw4A-2jc6A:
undetectable		 1tw4A-2jc6A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		3 TYR A 203
ARG A 159
GLN A 261
 None
 0.94A 1tw4A-2kdyA:
3.4		 1tw4A-2kdyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0k POLYCOMB PROTEIN
SCMH1

(Homo sapiens) 		PF02820
(MBT) 		3 TYR A 210
ARG A 217
GLN A  49
 None
 0.88A 1tw4A-2p0kA:
undetectable		 1tw4A-2p0kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7b ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
agalactiae) 		PF00583
(Acetyltransf_1) 		3 TYR A 130
ARG A 152
GLN A  24
 None
FLC  A 164 (-4.3A)
FLC  A 164 (-3.9A)
 0.82A 1tw4A-2q7bA:
undetectable		 1tw4A-2q7bA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 TYR A 290
ARG A 423
GLN A 351
 None
 1.00A 1tw4A-2qfrA:
undetectable		 1tw4A-2qfrA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 TYR A  82
ARG A 192
GLN A 160
 None
 0.98A 1tw4A-2qt3A:
undetectable		 1tw4A-2qt3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5m POLYCOMB PROTEIN SCM

(Drosophila
melanogaster) 		PF02820
(MBT) 		3 TYR A 357
ARG A 364
GLN A 196
 None
 0.90A 1tw4A-2r5mA:
undetectable		 1tw4A-2r5mA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 TYR A 649
ARG A 632
GLN A 690
 None
 0.94A 1tw4A-2x58A:
undetectable		 1tw4A-2x58A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x75 ADENYLOSUCCINATE
LYASE

(Staphylococcus
aureus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 TYR A  20
ARG A  67
GLN A  64
 None
 0.95A 1tw4A-2x75A:
undetectable		 1tw4A-2x75A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8k HYPOTHETICAL PROTEIN
19.1

(Bacillus phage
SPP1) 		PF05709
(Sipho_tail) 		3 TYR A 137
ARG A 109
GLN A 132
 None
 1.01A 1tw4A-2x8kA:
undetectable		 1tw4A-2x8kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		3 TYR A 187
ARG A 197
GLN A 198
 None
 0.97A 1tw4A-2y27A:
undetectable		 1tw4A-2y27A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		3 TYR A 177
ARG A  99
GLN A  95
 None
 0.96A 1tw4A-2y8vA:
undetectable		 1tw4A-2y8vA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 TYR A 150
ARG A 270
GLN A  75
 None
 0.93A 1tw4A-2yfnA:
undetectable		 1tw4A-2yfnA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxk VOLTAGE-DEPENDENT
P/Q-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1A PEPTIDE

(Homo sapiens) 		no annotation 3 TYR B1962
ARG B1972
GLN B1973
 None
 0.93A 1tw4A-3bxkB:
undetectable		 1tw4A-3bxkB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		3 TYR A 311
ARG A  27
GLN A  23
 None
None
CL  A 332 (-4.2A)
 0.95A 1tw4A-3c17A:
undetectable		 1tw4A-3c17A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		3 TYR A 249
ARG A  77
GLN A  72
 None
 0.98A 1tw4A-3dcdA:
1.6		 1tw4A-3dcdA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 154
ARG A 337
GLN A 323
 None
 0.97A 1tw4A-3eezA:
undetectable		 1tw4A-3eezA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 159
ARG A 337
GLN A 323
 None
 0.88A 1tw4A-3eezA:
undetectable		 1tw4A-3eezA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		3 TYR A 348
ARG A 281
GLN A 278
 None
 0.79A 1tw4A-3fipA:
2.8		 1tw4A-3fipA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		3 TYR A 308
ARG A 162
GLN A 159
 None
 1.00A 1tw4A-3g68A:
undetectable		 1tw4A-3g68A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		3 TYR A 124
ARG A 114
GLN A  65
 None
SO4  A 326 (-4.4A)
None
 0.92A 1tw4A-3kskA:
undetectable		 1tw4A-3kskA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		3 TYR A 284
ARG A 274
GLN A 225
 None
 0.87A 1tw4A-3kskA:
undetectable		 1tw4A-3kskA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 3 TYR B 440
ARG B 427
GLN B 423
 None
 1.02A 1tw4A-3kx2B:
undetectable		 1tw4A-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3laq UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR

(Mus musculus) 		PF00021
(UPAR_LY6) 		3 TYR U 141
ARG U 214
GLN U 183
 None
 0.89A 1tw4A-3laqU:
undetectable		 1tw4A-3laqU:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mel THIAMIN
PYROPHOSPHOKINASE
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 TYR A 139
ARG A 120
GLN A  81
 None
 0.93A 1tw4A-3melA:
undetectable		 1tw4A-3melA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		3 TYR A 125
ARG A 118
GLN A 119
 None
 0.99A 1tw4A-3nixA:
undetectable		 1tw4A-3nixA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A 303
ARG A 130
GLN A 127
 None
 1.00A 1tw4A-3nizA:
undetectable		 1tw4A-3nizA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		3 TYR B 248
ARG B 362
GLN B 359
 None
 0.96A 1tw4A-3nvnB:
1.7		 1tw4A-3nvnB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o44 HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		3 TYR A 194
ARG A 531
GLN A 526
 None
 0.92A 1tw4A-3o44A:
1.6		 1tw4A-3o44A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 TYR A 548
ARG A 100
GLN A  97
 None
 1.01A 1tw4A-3pieA:
undetectable		 1tw4A-3pieA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica;
Salmonella
enterica) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		3 TYR B  16
ARG A 140
GLN A 141
 None
 0.96A 1tw4A-3pr2B:
undetectable		 1tw4A-3pr2B:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90) 		3 TYR A 493
ARG A 456
GLN A 532
 None
 0.99A 1tw4A-3q6mA:
undetectable		 1tw4A-3q6mA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon;
uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 507
ARG C 244
GLN A 470
 None
 0.98A 1tw4A-3sqgA:
undetectable		 1tw4A-3sqgA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1

(Burkholderia
ambifaria) 		PF00793
(DAHP_synth_1) 		3 TYR A  53
ARG A  81
GLN A  82
 None
 1.00A 1tw4A-3t4cA:
undetectable		 1tw4A-3t4cA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A
ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
PF12705
(PDDEXK_1) 		3 TYR B 366
ARG A 741
GLN A 737
 None
 1.03A 1tw4A-3u44B:
undetectable		 1tw4A-3u44B:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 TYR A 124
ARG A 136
GLN A  77
 None
 0.94A 1tw4A-3ufbA:
undetectable		 1tw4A-3ufbA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgh REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Thermoanaerobacter
ethanolicus) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		3 TYR A  66
ARG A  14
GLN A  48
 None
 0.97A 1tw4A-3wghA:
undetectable		 1tw4A-3wghA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh7 PROTEIN E

(Haemophilus
influenzae) 		PF16747
(Adhesin_E) 		3 TYR A  81
ARG A  92
GLN A 118
 None
 0.82A 1tw4A-3zh7A:
2.6		 1tw4A-3zh7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		3 TYR A 464
ARG A 204
GLN A 354
 None
 0.96A 1tw4A-4a1fA:
undetectable		 1tw4A-4a1fA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		3 TYR A 391
ARG A  44
GLN A  47
 None
 1.03A 1tw4A-4drsA:
undetectable		 1tw4A-4drsA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 TYR A  95
ARG A 162
GLN A 180
 None
SSA  A1001 (-2.8A)
SSA  A1001 (-3.4A)
 0.94A 1tw4A-4eo4A:
undetectable		 1tw4A-4eo4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 TYR A 150
ARG A 270
GLN A  74
 None
 0.91A 1tw4A-4fnqA:
undetectable		 1tw4A-4fnqA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		3 TYR A  80
ARG A 204
GLN A 201
 None
 1.00A 1tw4A-4hb9A:
undetectable		 1tw4A-4hb9A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		3 TYR C 189
ARG C  61
GLN C 278
 None
 0.89A 1tw4A-4ifdC:
undetectable		 1tw4A-4ifdC:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 TYR A 247
ARG A 406
GLN A 119
 None
 0.81A 1tw4A-4k3yA:
undetectable		 1tw4A-4k3yA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		3 TYR A  34
ARG A  73
GLN A 112
 None
 0.93A 1tw4A-4kdsA:
undetectable		 1tw4A-4kdsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		3 TYR A 201
ARG A  70
GLN A 259
 None
 0.92A 1tw4A-4mt6A:
undetectable		 1tw4A-4mt6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohx PROTEIN CLPF-1

(Caenorhabditis
elegans) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		3 TYR A 200
ARG A 297
GLN A 154
 None
None
ADP  A 501 ( 4.7A)
 0.96A 1tw4A-4ohxA:
undetectable		 1tw4A-4ohxA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		3 TYR A 120
ARG A 149
GLN A 176
 None
LFC  A 403 (-2.7A)
LFC  A 403 ( 4.7A)
 1.02A 1tw4A-4ovtA:
undetectable		 1tw4A-4ovtA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozd 14.4 KDA SALIVARY
PROTEIN

(Phlebotomus
duboscqi) 		PF01395
(PBP_GOBP) 		3 TYR A  94
ARG A  44
GLN A  40
 None
 0.85A 1tw4A-4ozdA:
undetectable		 1tw4A-4ozdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		3 TYR A1867
ARG A1797
GLN A1794
 None
 1.01A 1tw4A-4p1tA:
undetectable		 1tw4A-4p1tA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		3 TYR A 106
ARG A 140
GLN A 138
 None
 1.01A 1tw4A-4pz7A:
undetectable		 1tw4A-4pz7A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B  38
ARG B 136
GLN B  74
 None
 0.92A 1tw4A-4qiwB:
undetectable		 1tw4A-4qiwB:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		3 TYR A 190
ARG A 116
GLN A 113
 None
None
ANP  A 402 ( 4.2A)
 0.89A 1tw4A-4qnyA:
undetectable		 1tw4A-4qnyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGS

(Sphingomonas
sp.;
Sphingomonas
sp.) 		PF00528
(BPD_transp_1)
PF00005
(ABC_tran)
PF03459
(TOBE) 		3 TYR C  88
ARG A 226
GLN A 220
 None
 0.84A 1tw4A-4tqvC:
undetectable		 1tw4A-4tqvC:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 TYR A 128
ARG A 138
GLN A 139
 None
 1.00A 1tw4A-4uj6A:
undetectable		 1tw4A-4uj6A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uut HOMEOTIC PROTEIN
ULTRABITHORAX

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		3 TYR A   8
ARG A  53
GLN A  50
 None
SO4  A1074 (-4.0A)
None
 1.03A 1tw4A-4uutA:
undetectable		 1tw4A-4uutA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		3 TYR A  92
ARG A 244
GLN A  37
 None
 0.80A 1tw4A-4w8oA:
undetectable		 1tw4A-4w8oA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 TYR A 114
ARG A  77
GLN A  73
 None
 0.93A 1tw4A-4wboA:
undetectable		 1tw4A-4wboA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 TYR A2420
ARG A2337
GLN A2333
 None
 1.00A 1tw4A-4x0qA:
undetectable		 1tw4A-4x0qA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 TYR A  31
ARG A  43
GLN A  44
 CTP  A 402 ( 3.9A)
None
None
 0.87A 1tw4A-4xsvA:
undetectable		 1tw4A-4xsvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 TYR A 162
ARG A 155
GLN A 156
 None
 0.93A 1tw4A-4yv2A:
undetectable		 1tw4A-4yv2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 490
ARG C 244
GLN A 453
 None
None
DYA  A 452 ( 4.6A)
 0.91A 1tw4A-5a8rA:
undetectable		 1tw4A-5a8rA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		3 TYR A1120
ARG A 292
GLN A 291
 G  C   7 ( 3.5A)
U  C   6 ( 3.1A)
U  C   6 ( 4.1A)
 0.97A 1tw4A-5amqA:
undetectable		 1tw4A-5amqA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Mus musculus) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		3 TYR A 110
ARG A  86
GLN A  83
 None
 1.00A 1tw4A-5axiA:
undetectable		 1tw4A-5axiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii;
Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		3 TYR A 611
ARG B  10
GLN A 436
 None
 0.85A 1tw4A-5c6gA:
undetectable		 1tw4A-5c6gA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		3 TYR A1453
ARG A1426
GLN A1605
 None
 0.89A 1tw4A-5czvA:
undetectable		 1tw4A-5czvA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 TYR A 224
ARG A  95
GLN A  91
 None
 0.94A 1tw4A-5d79A:
undetectable		 1tw4A-5d79A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		3 TYR A 688
ARG A 240
GLN A 202
 None
 0.99A 1tw4A-5fswA:
undetectable		 1tw4A-5fswA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2
VP3

(Deformed wing
virus;
Deformed wing
virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 TYR B 156
ARG B 214
GLN C  69
 None
 0.96A 1tw4A-5g52B:
undetectable		 1tw4A-5g52B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 TYR A  30
ARG A 288
GLN A 292
 None
 0.87A 1tw4A-5hm5A:
undetectable		 1tw4A-5hm5A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		3 TYR A 701
ARG A 649
GLN A 645
 None
 0.60A 1tw4A-5hzrA:
undetectable		 1tw4A-5hzrA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		3 TYR A 299
ARG A 207
GLN B 120
 None
 0.60A 1tw4A-5ivaA:
1.1		 1tw4A-5ivaA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		3 TYR A  70
ARG A 296
GLN A 392
 None
 1.01A 1tw4A-5j5uA:
undetectable		 1tw4A-5j5uA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		3 TYR B  49
ARG B 480
GLN B 478
 None
 0.78A 1tw4A-5lxzB:
undetectable		 1tw4A-5lxzB:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4y EXOCYST COMPLEX
COMPONENT SEC3

(Saccharomyces
cerevisiae) 		PF15277
(Sec3-PIP2_bind) 		3 TYR B 108
ARG B 113
GLN B  81
 None
 0.99A 1tw4A-5m4yB:
undetectable		 1tw4A-5m4yB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs MICROTUBULE
INTEGRITY PROTEIN
MAL3

(Schizosaccharomyces
pombe) 		no annotation 3 TYR D  58
ARG D 117
GLN D  34
 None
 0.65A 1tw4A-5mjsD:
undetectable		 1tw4A-5mjsD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 TYR A 490
ARG C 245
GLN A 453
 TRX  A 429 ( 4.8A)
None
None
 0.98A 1tw4A-5n28A:
undetectable		 1tw4A-5n28A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		3 TYR A1308
ARG A1377
GLN A1374
 None
 0.86A 1tw4A-5t03A:
undetectable		 1tw4A-5t03A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi) 		PF06224
(HTH_42) 		3 TYR A  90
ARG A  51
GLN A  16
 None
 0.77A 1tw4A-5uujA:
undetectable		 1tw4A-5uujA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L14
50S RIBOSOMAL
PROTEIN L19

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00238
(Ribosomal_L14)
PF01245
(Ribosomal_L19) 		3 TYR P  65
ARG K 104
GLN P  40
 None
 0.97A 1tw4A-5v7qP:
undetectable		 1tw4A-5v7qP:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 TYR A 450
ARG A 419
GLN A 415
 None
 0.99A 1tw4A-5xfmA:
2.3		 1tw4A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 3 TYR G  55
ARG G  24
GLN G  20
 None
 0.76A 1tw4A-6criG:
undetectable		 1tw4A-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 3 TYR A 367
ARG A 263
GLN A 257
 None
 1.03A 1tw4A-6d35A:
undetectable		 1tw4A-6d35A:
undetectable