SIMILAR PATTERNS OF AMINO ACIDS FOR 1TV8_B_SAMB2501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP1)
PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis
virus;
Cricket
paralysis virus) 		PF08762
(CRPV_capsid)
no annotation 		4 TYR A 247
THR C  42
SER A 244
VAL C  53
 None
 1.22A 1tv8B-1b35A:
undetectable		 1tv8B-1b35A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR O 179
GLU O 314
SER O 238
VAL O 240
 SO4  O 338 (-3.5A)
None
None
None
 1.09A 1tv8B-1dbvO:
undetectable		 1tv8B-1dbvO:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 471
THR A 527
SER A 544
VAL A 563
 None
 1.19A 1tv8B-1e8tA:
undetectable		 1tv8B-1e8tA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE
ARSENITE OXIDASE

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF00355
(Rieske) 		4 TYR A 727
THR B  75
GLU B  88
VAL A 762
 None
 0.94A 1tv8B-1g8kA:
0.0		 1tv8B-1g8kA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 TYR A 315
THR A 325
THR A 322
VAL A 256
 None
 1.14A 1tv8B-1h3gA:
4.0		 1tv8B-1h3gA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		4 TYR A  74
THR A  17
THR A  20
SER A  24
 None
MG  A 302 ( 3.4A)
None
None
 1.19A 1tv8B-1ionA:
3.4		 1tv8B-1ionA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6a FIBER PROTEIN

(Human
mastadenovirus
A) 		PF00541
(Adeno_knob) 		4 TYR A 583
THR A 532
SER A 530
VAL A 546
 None
 1.20A 1tv8B-1p6aA:
undetectable		 1tv8B-1p6aA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl7 ADENYLATE CYCLASE,
TYPE V

(Canis lupus) 		PF00211
(Guanylate_cyc) 		4 TYR A 443
THR A 529
THR A 532
VAL A 445
 FOK  A 101 (-4.4A)
None
None
None
 1.16A 1tv8B-1tl7A:
undetectable		 1tv8B-1tl7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 134
THR A 130
SER A  91
VAL A  96
 None
 1.10A 1tv8B-1tt7A:
undetectable		 1tv8B-1tt7A:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		6 THR A  73
GLU A  76
THR A 102
SER A 126
VAL A 167
MET A 197
 SAM  A1501 (-4.0A)
SAM  A1501 (-4.4A)
SAM  A1501 (-4.3A)
SAM  A1501 ( 2.4A)
SAM  A1501 (-4.5A)
DTU  A1502 (-4.2A)
 0.30A 1tv8B-1tv8A:
51.8		 1tv8B-1tv8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 THR A 101
THR A 222
SER A 219
VAL A 161
 MLY  A 221 ( 4.7A)
MLY  A 221 ( 4.3A)
MLY  A 159 ( 4.5A)
None
 1.16A 1tv8B-1vk1A:
undetectable		 1tv8B-1vk1A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 THR A 302
THR A 304
SER A 239
MET A 519
 PQQ  A 801 ( 4.5A)
None
None
None
 1.16A 1tv8B-1yiqA:
undetectable		 1tv8B-1yiqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Plasmodium
falciparum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR O 183
GLU O 320
SER O 244
VAL O 246
 NAD  O 401 (-4.5A)
None
None
None
 1.23A 1tv8B-1ywgO:
undetectable		 1tv8B-1ywgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Plasmodium
falciparum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 TYR O 323
THR O 335
THR O   4
VAL O  18
 NAD  O 401 (-3.7A)
None
None
None
 1.09A 1tv8B-1ywgO:
undetectable		 1tv8B-1ywgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		4 THR A  19
THR A 156
VAL A 139
MET A 437
 None
 1.17A 1tv8B-1z2zA:
undetectable		 1tv8B-1z2zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		4 THR A  28
THR A  12
VAL A  94
MET A  77
 None
 0.97A 1tv8B-1zbsA:
undetectable		 1tv8B-1zbsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 TYR H 141
THR H 174
THR H 178
VAL H 165
 None
 1.18A 1tv8B-2bbkH:
undetectable		 1tv8B-2bbkH:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 THR A 322
SER A 316
VAL A 260
MET A  62
 None
 1.16A 1tv8B-2cw6A:
5.1		 1tv8B-2cw6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 TYR A 179
GLU A 416
THR A 411
VAL A 185
 None
 1.09A 1tv8B-2dpgA:
2.1		 1tv8B-2dpgA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2c PUTATIVE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN

(Corynebacterium
diphtheriae) 		PF00994
(MoCF_biosynth) 		4 THR A  84
GLU A  50
THR A  76
SER A 138
 None
None
NA  A 301 (-3.3A)
NA  A 301 (-3.6A)
 1.20A 1tv8B-2g2cA:
undetectable		 1tv8B-2g2cA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 THR A 365
THR A 327
SER A 310
VAL A 295
 None
 0.91A 1tv8B-2ggqA:
undetectable		 1tv8B-2ggqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 TYR A 131
THR A 290
GLU A  93
THR A 289
 None
 1.17A 1tv8B-2h8hA:
undetectable		 1tv8B-2h8hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 TYR A 241
THR A 225
THR A  17
VAL A 200
 None
 1.12A 1tv8B-2ho4A:
undetectable		 1tv8B-2ho4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 360
GLU A 410
THR A 407
SER A 425
 None
 1.16A 1tv8B-2og8A:
undetectable		 1tv8B-2og8A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 THR A 180
GLU A 178
THR A 182
VAL A 158
 None
 1.07A 1tv8B-2ph1A:
2.8		 1tv8B-2ph1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xri ERI1 EXORIBONUCLEASE
3

(Homo sapiens) 		PF00929
(RNase_T) 		4 TYR A 260
GLU A 222
SER A 216
VAL A 191
 None
 1.24A 1tv8B-2xriA:
undetectable		 1tv8B-2xriA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 TYR A 742
GLU A 794
THR A 791
SER A 809
 GOL  A1893 (-4.0A)
None
None
None
 1.11A 1tv8B-2xyuA:
undetectable		 1tv8B-2xyuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		4 TYR A 251
THR A 305
THR A 273
SER A 347
 None
 1.09A 1tv8B-2yjnA:
undetectable		 1tv8B-2yjnA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 TYR A  13
THR A 107
THR A 109
SER A 111
 None
 1.10A 1tv8B-3aizA:
undetectable		 1tv8B-3aizA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 TYR A 366
THR A 319
GLU A 315
SER A 342
 None
None
MG  A 601 ( 2.6A)
None
 1.23A 1tv8B-3au9A:
undetectable		 1tv8B-3au9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 185
GLU A 319
SER A 243
VAL A 245
 SO4  A1340 (-3.0A)
None
None
None
 1.08A 1tv8B-3b20A:
undetectable		 1tv8B-3b20A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		4 THR A  73
GLU A 107
SER A 131
VAL A 198
 None
 1.11A 1tv8B-3bblA:
undetectable		 1tv8B-3bblA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		4 GLU A 195
SER A 219
VAL A 217
MET A 208
 GOL  A   4 (-2.7A)
None
None
None
 1.13A 1tv8B-3d02A:
undetectable		 1tv8B-3d02A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 704
GLU A 689
SER A 124
VAL A 206
 None
 1.04A 1tv8B-3ddrA:
undetectable		 1tv8B-3ddrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 4 THR O 184
GLU O 319
SER O 243
VAL O 245
 SO4  O6920 (-2.5A)
None
None
None
 1.20A 1tv8B-3e6aO:
undetectable		 1tv8B-3e6aO:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edt KINESIN LIGHT CHAIN
2

(Homo sapiens) 		PF13374
(TPR_10)
PF13424
(TPR_12) 		4 TYR B 376
THR B 447
THR B 450
SER B 454
 None
 1.13A 1tv8B-3edtB:
undetectable		 1tv8B-3edtB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 184
GLU A 317
SER A 242
VAL A 244
 None
 1.19A 1tv8B-3gnqA:
undetectable		 1tv8B-3gnqA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hag CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		4 TYR A 323
THR A 144
THR A 146
SER A 326
 None
 1.21A 1tv8B-3hagA:
undetectable		 1tv8B-3hagA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A
EIF3C

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11)
PF00203
(Ribosomal_S19) 		4 THR o 490
THR o 481
SER p 734
VAL p 777
 None
 1.06A 1tv8B-3japo:
undetectable		 1tv8B-3japo:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 179
GLU A 314
SER A 238
VAL A 240
 SO4  A 336 (-3.7A)
None
None
None
 1.23A 1tv8B-3k2bA:
undetectable		 1tv8B-3k2bA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 TYR A 294
THR A 327
THR A 324
MET A 301
 None
 1.24A 1tv8B-3nheA:
undetectable		 1tv8B-3nheA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 GLU A 321
THR A 306
SER A 329
VAL A  72
 None
 1.02A 1tv8B-3r75A:
undetectable		 1tv8B-3r75A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 THR A 314
GLU A 321
SER A 329
VAL A  72
 None
 1.12A 1tv8B-3r75A:
undetectable		 1tv8B-3r75A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		4 TYR A 186
GLU A 296
SER A 256
VAL A 230
 NAD  A2402 (-4.4A)
None
None
None
 1.05A 1tv8B-3sxpA:
2.5		 1tv8B-3sxpA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1e HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 470
THR A 526
SER A 543
VAL A 562
 None
 1.08A 1tv8B-3t1eA:
undetectable		 1tv8B-3t1eA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.11A 1tv8B-3t6cA:
4.1		 1tv8B-3t6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1

(Homo sapiens) 		PF12026
(DUF3513) 		4 THR B 829
THR B 830
SER B 782
VAL B 762
 None
 1.16A 1tv8B-3t6gB:
undetectable		 1tv8B-3t6gB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 THR A  33
THR A  38
SER A  42
VAL A 150
 ATP  A 288 (-3.7A)
None
None
None
 1.18A 1tv8B-3ufgA:
undetectable		 1tv8B-3ufgA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PENTON PROTEIN

(Bovine
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 TYR M 299
THR M 212
GLU M 306
THR M 286
 None
 1.22A 1tv8B-3zifM:
undetectable		 1tv8B-3zifM:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 THR A1232
THR A1229
SER A1225
VAL A 927
 None
 1.16A 1tv8B-4acqA:
undetectable		 1tv8B-4acqA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		4 THR A  83
GLU A  74
THR A  85
VAL A  54
 None
 1.20A 1tv8B-4aznA:
undetectable		 1tv8B-4aznA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 471
THR A 527
SER A 544
VAL A 563
 None
 1.13A 1tv8B-4fzhA:
undetectable		 1tv8B-4fzhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gul PIRIN

(Homo sapiens) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 THR A 169
GLU A 244
THR A 167
VAL A 250
 None
 1.12A 1tv8B-4gulA:
undetectable		 1tv8B-4gulA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.08A 1tv8B-4ihcA:
3.1		 1tv8B-4ihcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 TYR A 131
THR A 290
GLU A  93
THR A 289
 None
 1.09A 1tv8B-4k11A:
undetectable		 1tv8B-4k11A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 TYR A 382
GLU A 432
THR A 429
SER A 447
 None
 1.06A 1tv8B-4k11A:
undetectable		 1tv8B-4k11A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 THR A 289
GLU A  15
THR A 309
SER A 141
 None
 1.03A 1tv8B-4lb0A:
undetectable		 1tv8B-4lb0A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o29 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrobaculum
aerophilum) 		PF01135
(PCMT) 		4 GLU A  78
SER A  83
VAL A  33
MET A  40
 SAH  A 500 (-4.3A)
SAH  A 500 (-2.9A)
None
None
 1.13A 1tv8B-4o29A:
undetectable		 1tv8B-4o29A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rb0 DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR OF
SIDEROPHORE
BIOSYNTHESIS AND
TRANSPORT(FUR
FAMILY)

(Magnetospirillum
gryphiswaldense) 		PF01475
(FUR) 		4 TYR A  80
THR A  17
GLU A   6
VAL A  39
 None
 1.14A 1tv8B-4rb0A:
undetectable		 1tv8B-4rb0A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 THR A 286
THR A 288
VAL A  90
MET A  85
 None
None
HEM  A 503 (-3.8A)
None
 1.08A 1tv8B-4wpzA:
undetectable		 1tv8B-4wpzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		4 THR A 289
THR A 287
SER A 283
VAL A 280
 None
 1.23A 1tv8B-4x8iA:
undetectable		 1tv8B-4x8iA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		4 TYR A 137
THR A  34
GLU A 231
MET A 125
 None
 0.81A 1tv8B-4xzbA:
4.7		 1tv8B-4xzbA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(uncultured
bacterium;
Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		4 TYR A 137
THR A  34
GLU A 230
MET A 125
 None
None
EPE  A 404 (-4.3A)
None
 0.89A 1tv8B-4xzwA:
4.1		 1tv8B-4xzwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 TYR A 366
THR A 319
GLU A 315
SER A 342
 None
None
MN  A 502 ( 2.6A)
None
 1.23A 1tv8B-4y67A:
undetectable		 1tv8B-4y67A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		4 TYR A 164
THR A 126
GLU A  14
VAL A 131
 None
None
ACT  A 401 (-4.3A)
None
 1.06A 1tv8B-4yogA:
undetectable		 1tv8B-4yogA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z48 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF17131
(LolA_like) 		4 TYR A  73
THR A 229
SER A  48
VAL A 255
 None
 1.15A 1tv8B-4z48A:
undetectable		 1tv8B-4z48A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zej METALLO-BETA-LACTAMA
SE

(Pseudomonas
stutzeri) 		no annotation 4 TYR A 116
THR A  56
THR A  49
SER A  75
 None
 1.23A 1tv8B-4zejA:
undetectable		 1tv8B-4zejA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 THR A 338
GLU A 336
THR A 364
MET A 321
 None
 1.21A 1tv8B-4zm4A:
undetectable		 1tv8B-4zm4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Acinetobacter
baumannii) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 TYR A 173
GLU A 239
SER A 266
VAL A 268
 None
SO4  A 501 ( 4.5A)
None
None
 1.23A 1tv8B-4zn6A:
undetectable		 1tv8B-4zn6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 TYR B 100
THR B 151
THR B 154
SER B 158
 None
 1.21A 1tv8B-5dlqB:
undetectable		 1tv8B-5dlqB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		4 THR A 280
THR A 203
VAL A 265
MET A 178
 None
UDP  A 401 ( 4.4A)
UDP  A 401 (-3.7A)
None
 1.13A 1tv8B-5enzA:
undetectable		 1tv8B-5enzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLU A 147
THR A 242
SER A 506
VAL A 525
 GOL  A 705 (-2.8A)
None
None
None
 1.18A 1tv8B-5gxdA:
undetectable		 1tv8B-5gxdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 4 TYR A 686
THR A 828
THR A 901
VAL A 690
 None
 1.23A 1tv8B-5h2rA:
undetectable		 1tv8B-5h2rA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		4 THR A 328
THR A 366
SER A 229
VAL A 261
 None
 1.22A 1tv8B-5hkjA:
undetectable		 1tv8B-5hkjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 TYR A 374
GLU A 819
THR A 483
VAL A 463
 None
 1.21A 1tv8B-5ikpA:
undetectable		 1tv8B-5ikpA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 TYR A 374
THR A 816
GLU A 823
VAL A 463
 None
 1.15A 1tv8B-5ikpA:
undetectable		 1tv8B-5ikpA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 THR A 332
THR A 314
SER A 312
VAL A 210
 None
 1.16A 1tv8B-5iwzA:
undetectable		 1tv8B-5iwzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 THR A 173
THR A 375
SER A 253
VAL A 349
 None
 1.15A 1tv8B-5kvuA:
undetectable		 1tv8B-5kvuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 THR A 119
THR A 128
SER A 222
VAL A  70
 None
 1.20A 1tv8B-5l6fA:
undetectable		 1tv8B-5l6fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 TYR B 327
THR B 229
GLU B 225
VAL B 624
 None
 1.13A 1tv8B-5l9wB:
undetectable		 1tv8B-5l9wB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mln ALCOHOL
DEHYDROGENASE 3

([Candida]
magnoliae) 		no annotation 4 THR A 192
GLU A 211
THR A 190
VAL A 219
 NAP  A 301 (-2.7A)
None
NAP  A 301 (-4.3A)
None
 1.17A 1tv8B-5mlnA:
2.2		 1tv8B-5mlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		4 THR 11056
THR 11045
SER 1 912
VAL 1 906
 None
 1.13A 1tv8B-5mz61:
undetectable		 1tv8B-5mz61:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o77 OMPK35

(Klebsiella
pneumoniae) 		no annotation 4 TYR A 264
THR A 232
THR A 228
SER A 226
 None
 1.18A 1tv8B-5o77A:
undetectable		 1tv8B-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 4 TYR A  18
GLU A  62
THR A  30
SER A 435
 None
 1.14A 1tv8B-5oieA:
undetectable		 1tv8B-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 TYR A 659
THR A 593
THR A 619
SER A 695
 None
 1.20A 1tv8B-5te1A:
undetectable		 1tv8B-5te1A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 TYR B 659
THR B 593
THR B 619
SER B 695
 None
 1.19A 1tv8B-5tetB:
undetectable		 1tv8B-5tetB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 TYR A  44
GLU A 133
SER A 146
VAL A 149
 None
 0.92A 1tv8B-5u6fA:
undetectable		 1tv8B-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		4 GLU A 161
THR A 185
SER A 210
VAL A 249
 SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.39A 1tv8B-5v1sA:
22.1		 1tv8B-5v1sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0e FREE SERINE KINASE

(Thermococcus
kodakarensis) 		PF02195
(ParBc) 		4 THR A 101
THR A 222
SER A 219
VAL A 161
 None
 1.18A 1tv8B-5x0eA:
undetectable		 1tv8B-5x0eA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 TYR A 964
THR A 687
THR A 685
VAL A 932
 None
 1.01A 1tv8B-5x7sA:
undetectable		 1tv8B-5x7sA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 4 THR A  61
THR A  77
SER A  74
MET A  52
 None
 0.88A 1tv8B-5x8zA:
undetectable		 1tv8B-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		4 TYR A 142
THR A 153
THR A 155
VAL A 159
 None
 1.21A 1tv8B-5xcyA:
4.8		 1tv8B-5xcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 THR A 774
THR A 746
SER A 849
MET A 800
 None
 1.17A 1tv8B-5xvmA:
undetectable		 1tv8B-5xvmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 4 GLU A 535
THR A 579
VAL A 566
MET A 143
 None
 0.99A 1tv8B-5y6rA:
undetectable		 1tv8B-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2

(Homo sapiens) 		no annotation 4 TYR A 301
THR A 203
THR A 200
SER A 232
 None
 1.05A 1tv8B-6apjA:
undetectable		 1tv8B-6apjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 4 THR A  80
THR A  84
VAL A 149
MET A 135
 None
LLP  A 181 ( 4.9A)
None
None
 1.19A 1tv8B-6blgA:
undetectable		 1tv8B-6blgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT A

(Flavobacterium
johnsoniae) 		no annotation 4 TYR A 412
GLU A 427
THR A 403
VAL A 367
 None
None
HEC  A1003 (-3.4A)
None
 1.04A 1tv8B-6btmA:
undetectable		 1tv8B-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwl PAL

(Bacillus
thuringiensis) 		no annotation 4 TYR A 163
THR A 100
THR A 103
VAL A 169
 None
 1.19A 1tv8B-6bwlA:
undetectable		 1tv8B-6bwlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 TYR A 308
GLU A 357
THR A 354
SER A 372
 FKY  A9001 (-4.4A)
None
None
None
 1.05A 1tv8B-6cz4A:
undetectable		 1tv8B-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 TYR F 137
THR F 104
GLU F 226
THR F 331
 None
 1.08A 1tv8B-6g2jF:
undetectable		 1tv8B-6g2jF:
undetectable