SIMILAR PATTERNS OF AMINO ACIDS FOR 1TUF_B_AZ1B503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 GLU A  35
SER A 265
ARG A  43
TYR A 399
 FAD  A 579 (-2.7A)
FAD  A 579 (-4.1A)
FAD  A 579 (-3.6A)
FAD  A 579 (-4.3A)
 0.95A 1tufA-1h81A:
undetectable
1tufB-1h81A:
undetectable		 1tufA-1h81A:
20.89
1tufB-1h81A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2f SIAH-1A PROTEIN

(Mus musculus) 		PF03145
(Sina) 		4 GLU A 122
SER A 242
ARG A 124
TYR A 126
 None
 1.33A 1tufA-1k2fA:
undetectable
1tufB-1k2fA:
undetectable		 1tufA-1k2fA:
17.46
1tufB-1k2fA:
17.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ARG A 271
ARG A 307
TYR A 311
TYR A 378
 LYS  A 541 ( 3.3A)
LYS  A 541 (-4.0A)
LYS  A 541 ( 4.4A)
LYS  A 541 (-3.4A)
 0.88A 1tufA-1ko0A:
42.0
1tufB-1ko0A:
42.4		 1tufA-1ko0A:
32.05
1tufB-1ko0A:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF05899
(Cupin_3) 		4 GLU A1194
SER A1171
ARG A1154
TYR A1093
 None
 1.49A 1tufA-1sfnA:
undetectable
1tufB-1sfnA:
undetectable		 1tufA-1sfnA:
20.09
1tufB-1sfnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLU A  83
SER A  33
ARG A  27
TYR A  22
 None
 1.23A 1tufA-1y9gA:
undetectable
1tufB-1y9gA:
undetectable		 1tufA-1y9gA:
22.35
1tufB-1y9gA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 GLU A 234
ARG A 223
ARG A 224
TYR A 209
 None
 1.49A 1tufA-1yfoA:
undetectable
1tufB-1yfoA:
undetectable		 1tufA-1yfoA:
21.94
1tufB-1yfoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13302
(Acetyltransf_3) 		4 SER A  35
ARG A  27
TYR A  26
TYR A  42
 None
 1.44A 1tufA-2fsrA:
undetectable
1tufB-2fsrA:
undetectable		 1tufA-2fsrA:
16.09
1tufB-2fsrA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		4 GLU A 298
SER A 373
ARG E 515
ARG E 468
 None
 1.29A 1tufA-2nxxA:
undetectable
1tufB-2nxxA:
undetectable		 1tufA-2nxxA:
19.48
1tufB-2nxxA:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 SER A 207
ARG A 282
ARG A 318
TYR A 322
TYR A 377
 None
 0.66A 1tufA-2p3eA:
52.9
1tufB-2p3eA:
53.1		 1tufA-2p3eA:
42.99
1tufB-2p3eA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 SER A 188
ARG A 262
ARG A 298
TYR A 358
 PLP  A 406 (-2.6A)
LYS  A 407 ( 2.6A)
LYS  A 407 (-3.5A)
LYS  A 407 ( 3.5A)
 0.73A 1tufA-2qghA:
48.9
1tufB-2qghA:
49.3		 1tufA-2qghA:
37.78
1tufB-2qghA:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 SER A 188
ARG A 262
TYR A 302
TYR A 358
 PLP  A 406 (-2.6A)
LYS  A 407 ( 2.6A)
LYS  A 407 (-4.0A)
LYS  A 407 ( 3.5A)
 0.37A 1tufA-2qghA:
48.9
1tufB-2qghA:
49.3		 1tufA-2qghA:
37.78
1tufB-2qghA:
37.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywi HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00578
(AhpC-TSA) 		4 SER A  13
ARG A 144
TYR A 143
TYR A 133
 None
 1.47A 1tufA-2ywiA:
undetectable
1tufB-2ywiA:
undetectable		 1tufA-2ywiA:
17.74
1tufB-2ywiA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 SER A 182
ARG A 249
ARG A 285
TYR A 289
TYR A 343
 PLP  A 401 (-2.6A)
None
None
None
PLP  A 401 (-4.6A)
 0.68A 1tufA-2yxxA:
47.1
1tufB-2yxxA:
47.5		 1tufA-2yxxA:
38.78
1tufB-2yxxA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 SER A 203
ARG A 279
ARG A 315
TYR A 319
TYR A 376
 LLP  A  61 ( 2.5A)
None
None
None
LLP  A  61 ( 4.6A)
 0.67A 1tufA-3vabA:
50.0
1tufB-3vabA:
50.2		 1tufA-3vabA:
37.04
1tufB-3vabA:
37.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 SER A 161
ARG A 165
TYR A 170
TYR A 169
 None
 1.41A 1tufA-3vocA:
5.2
1tufB-3vocA:
7.2		 1tufA-3vocA:
21.88
1tufB-3vocA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 GLU A 399
ARG A 339
ARG D 270
TYR A 354
 None
 1.48A 1tufA-3vr5A:
undetectable
1tufB-3vr5A:
undetectable		 1tufA-3vr5A:
21.38
1tufB-3vr5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dtg HUMANIZED
RECOMBINANT FAB
FRAGMENT, FAB 2021,
OF A MURINE
ANTIBODY, HEAVY
CHAIN
TISSUE FACTOR
PATHWAY INHIBITOR

(Homo sapiens) 		PF00014
(Kunitz_BPTI)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLU K  11
SER H  54
TYR H  59
TYR H  57
 PGE  H 304 ( 3.5A)
None
None
None
 1.21A 1tufA-4dtgK:
undetectable
1tufB-4dtgK:
undetectable		 1tufA-4dtgK:
9.76
1tufB-4dtgK:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 GLU A 474
SER A 404
ARG A 441
ARG A 580
 None
 1.29A 1tufA-4n2cA:
undetectable
1tufB-4n2cA:
undetectable		 1tufA-4n2cA:
19.23
1tufB-4n2cA:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 SER A 203
ARG A 277
ARG A 313
TYR A 376
 LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-3.8A)
LLP  A 508 (-3.4A)
 0.77A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 SER A 203
ARG A 277
TYR A 317
TYR A 376
 LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-4.2A)
LLP  A 508 (-3.4A)
 0.32A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 GLU A 158
SER A 153
ARG A 149
TYR A 146
 None
 1.43A 1tufA-5gneA:
undetectable
1tufB-5gneA:
undetectable		 1tufA-5gneA:
23.29
1tufB-5gneA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		4 GLU A 471
ARG A 494
TYR A 607
TYR A 610
 None
 1.07A 1tufA-5hmqA:
2.6
1tufB-5hmqA:
3.0		 1tufA-5hmqA:
21.90
1tufB-5hmqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 4 SER A 303
ARG A 317
ARG A 314
TYR A 307
 None
 1.11A 1tufA-5m89A:
undetectable
1tufB-5m89A:
undetectable		 1tufA-5m89A:
13.11
1tufB-5m89A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		4 GLU A 255
SER A  16
ARG A 240
TYR A 250
 None
 0.93A 1tufA-5mj7A:
undetectable
1tufB-5mj7A:
undetectable		 1tufA-5mj7A:
21.03
1tufB-5mj7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 4 GLU B 522
SER B 223
ARG B 494
TYR B 516
 None
 1.44A 1tufA-5xguB:
undetectable
1tufB-5xguB:
undetectable		 1tufA-5xguB:
20.15
1tufB-5xguB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 4 GLU A 327
SER A 346
ARG A 106
TYR A 101
 None
None
None
LLP  A 199 (-3.7A)
 1.48A 1tufA-6cjbA:
undetectable
1tufB-6cjbA:
undetectable		 1tufA-6cjbA:
9.47
1tufB-6cjbA:
9.47