SIMILAR PATTERNS OF AMINO ACIDS FOR 1TUF_A_AZ1A502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A 215
SER A 216
ARG A 303
ARG A 344
TYR A 348
 None
None
SO4  A 500 (-3.3A)
None
None
 1.19A 1tufA-1hkwA:
46.0
1tufB-1hkwA:
46.0		 1tufA-1hkwA:
31.60
1tufB-1hkwA:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		5 GLY A 119
ARG A 124
TYR A 270
GLU A 258
SER A 266
 None
 1.41A 1tufA-1kh2A:
0.1
1tufB-1kh2A:
2.0		 1tufA-1kh2A:
22.34
1tufB-1kh2A:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		6 HIS A 204
GLY A 206
SER A 207
ARG A 282
ARG A 318
TYR A 322
 None
 0.58A 1tufA-2p3eA:
52.9
1tufB-2p3eA:
53.1		 1tufA-2p3eA:
42.99
1tufB-2p3eA:
42.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 HIS A 185
GLY A 187
SER A 188
ARG A 262
ARG A 298
 PLP  A 406 (-3.5A)
None
PLP  A 406 (-2.6A)
LYS  A 407 ( 2.6A)
LYS  A 407 (-3.5A)
 0.64A 1tufA-2qghA:
48.9
1tufB-2qghA:
49.3		 1tufA-2qghA:
37.78
1tufB-2qghA:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 HIS A 185
GLY A 187
SER A 188
ARG A 262
TYR A 302
 PLP  A 406 (-3.5A)
None
PLP  A 406 (-2.6A)
LYS  A 407 ( 2.6A)
LYS  A 407 (-4.0A)
 0.45A 1tufA-2qghA:
48.9
1tufB-2qghA:
49.3		 1tufA-2qghA:
37.78
1tufB-2qghA:
37.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		5 GLY A 138
SER A  72
ARG A  24
TYR A 211
SER A 141
 None
GLU  A1280 (-2.7A)
GLU  A1280 (-3.0A)
GLU  A1280 (-4.7A)
None
 1.30A 1tufA-2vhaA:
undetectable
1tufB-2vhaA:
undetectable		 1tufA-2vhaA:
21.58
1tufB-2vhaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 GLY A 900
SER A 899
ARG A 897
ARG A 618
SER A 951
 None
 1.21A 1tufA-2xt6A:
undetectable
1tufB-2xt6A:
undetectable		 1tufA-2xt6A:
17.85
1tufB-2xt6A:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		6 HIS A 179
GLY A 181
SER A 182
ARG A 249
ARG A 285
TYR A 289
 PLP  A 401 (-3.6A)
None
PLP  A 401 (-2.6A)
None
None
None
 0.57A 1tufA-2yxxA:
47.1
1tufB-2yxxA:
47.5		 1tufA-2yxxA:
38.78
1tufB-2yxxA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		6 HIS A 200
GLY A 202
SER A 203
ARG A 279
ARG A 315
TYR A 319
 LLP  A  61 ( 3.6A)
None
LLP  A  61 ( 2.5A)
None
None
None
 0.62A 1tufA-3vabA:
50.0
1tufB-3vabA:
50.2		 1tufA-3vabA:
37.04
1tufB-3vabA:
37.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		6 HIS A 200
GLY A 202
SER A 203
ARG A 277
ARG A 313
TYR A 317
 LLP  A 508 (-3.5A)
None
LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-3.8A)
LLP  A 508 (-4.2A)
 0.73A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 GLY A 218
SER A 219
ARG A 302
ARG A 343
TYR A 347
 None
PLP  A 504 ( 4.8A)
LYS  A 505 ( 3.8A)
LYS  A 505 (-4.3A)
LYS  A 505 (-4.0A)
 1.17A 1tufA-5x7nA:
46.7
1tufB-5x7nA:
46.7		 1tufA-5x7nA:
11.50
1tufB-5x7nA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 HIS A 216
GLY A 218
SER A 219
ARG A 302
TYR A 347
 PLP  A 504 (-3.5A)
None
PLP  A 504 ( 4.8A)
LYS  A 505 ( 3.8A)
LYS  A 505 (-4.0A)
 1.12A 1tufA-5x7nA:
46.7
1tufB-5x7nA:
46.7		 1tufA-5x7nA:
11.50
1tufB-5x7nA:
11.50