SIMILAR PATTERNS OF AMINO ACIDS FOR 1TT6_B_DESB128_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis virus) 		no annotation 4 LYS C 198
LEU C 205
LEU C 196
SER C 193
 None
 1.08A 1tt6B-1b35C:
0.0		 1tt6B-1b35C:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.13A 1tt6B-1eb3A:
undetectable		 1tt6B-1eb3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 LEU A 321
ALA A  28
LEU A  26
SER A  23
 None
 1.13A 1tt6B-1fpqA:
0.0		 1tt6B-1fpqA:
16.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.48A 1tt6B-1gkeA:
21.9		 1tt6B-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 LEU A 119
ALA A 256
LEU A 122
SER A 123
 None
 1.13A 1tt6B-1guqA:
0.0		 1tt6B-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4

(Rattus
norvegicus) 		PF00106
(adh_short) 		4 LEU A 172
ALA A 150
LEU A 169
SER A 165
 None
 1.02A 1tt6B-1gz6A:
undetectable		 1tt6B-1gz6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 LEU A1081
ALA A1098
LEU A1083
SER A1085
 None
 1.02A 1tt6B-1jl5A:
0.0		 1tt6B-1jl5A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		4 LEU A 242
ALA A 205
LEU A 245
SER A 249
 None
 1.13A 1tt6B-1jpuA:
undetectable		 1tt6B-1jpuA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 LEU A 238
ALA A 201
LEU A 241
SER A 245
 None
 1.11A 1tt6B-1kq3A:
undetectable		 1tt6B-1kq3A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nov NODAMURA VIRUS COAT
PROTEINS

(Nodamura virus) 		PF01829
(Peptidase_A6) 		4 LEU A 114
ALA A 126
LEU A 124
SER A 142
 None
 1.07A 1tt6B-1novA:
undetectable		 1tt6B-1novA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		4 LEU A 300
ALA A 302
LEU A 236
SER A 238
 None
 1.09A 1tt6B-1q33A:
undetectable		 1tt6B-1q33A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 247
ALA A 241
LEU A 274
SER A 275
 None
 1.12A 1tt6B-1qgzA:
undetectable		 1tt6B-1qgzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		4 LEU A  72
ALA A  69
LEU A  67
SER A  64
 None
 0.93A 1tt6B-1sa3A:
undetectable		 1tt6B-1sa3A:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.64A 1tt6B-1sn2A:
20.8		 1tt6B-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Zea mays) 		PF00903
(Glyoxalase) 		4 LEU A 214
ALA A  72
LEU A  97
SER A  98
 None
 1.11A 1tt6B-1sp8A:
undetectable		 1tt6B-1sp8A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 393
ALA B 389
LEU B 395
SER B 396
 None
 1.11A 1tt6B-1t3qB:
undetectable		 1tt6B-1t3qB:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4n RIBONUCLEASE III

(Saccharomyces
cerevisiae) 		PF00035
(dsrm) 		4 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 1.07A 1tt6B-1t4nA:
undetectable		 1tt6B-1t4nA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.69A 1tt6B-1tfpA:
19.8		 1tt6B-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 None
 1.02A 1tt6B-1tfpA:
19.8		 1tt6B-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx0 PLECKSTRIN

(Homo sapiens) 		PF00169
(PH) 		4 LEU A 275
ALA A 341
LEU A 292
SER A 346
 None
 1.06A 1tt6B-1xx0A:
undetectable		 1tt6B-1xx0A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.65A 1tt6B-1yr2A:
undetectable		 1tt6B-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		4 LEU A  81
ALA A 108
LEU A  83
SER A  84
 None
 1.12A 1tt6B-1zc6A:
undetectable		 1tt6B-1zc6A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzp PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF08919
(F_actin_bind) 		4 LEU A 101
ALA A  66
LEU A  64
SER A  61
 None
 1.16A 1tt6B-1zzpA:
undetectable		 1tt6B-1zzpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bid PROTEIN (BID)

(Homo sapiens) 		PF06393
(BID) 		4 LEU A 115
ALA A 162
LEU A 168
SER A 167
 None
 1.07A 1tt6B-2bidA:
undetectable		 1tt6B-2bidA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		4 LEU A 103
ALA A 100
LEU A  98
SER A  95
 None
 1.06A 1tt6B-2dfaA:
undetectable		 1tt6B-2dfaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 LEU A 939
ALA A 910
LEU A 784
SER A 906
 EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
 0.94A 1tt6B-2eyqA:
undetectable		 1tt6B-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ikd PROPHENOLOXIDASE
ACTIVATING
PROTEINASE-2

(Manduca sexta) 		PF12032
(CLIP) 		4 LEU A  49
ALA A  53
LEU A  26
SER A  25
 None
 1.11A 1tt6B-2ikdA:
undetectable		 1tt6B-2ikdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jre C60-1 PDZ DOMAIN
PEPTIDE

(-) 		PF00595
(PDZ) 		4 LYS A  68
LEU A  70
LEU A  99
SER A  15
 None
 0.94A 1tt6B-2jreA:
undetectable		 1tt6B-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 LEU A 208
ALA A  57
LEU A 142
SER A 141
 None
 1.02A 1tt6B-2nlzA:
undetectable		 1tt6B-2nlzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 291
ALA A 304
LEU A 294
SER A 297
 None
 1.02A 1tt6B-2o3jA:
undetectable		 1tt6B-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd1 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		no annotation 4 LEU A  81
ALA A  79
LEU A  82
SER A  84
 None
 1.06A 1tt6B-2pd1A:
undetectable		 1tt6B-2pd1A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		4 LEU A 181
ALA A 194
LEU A 184
SER A 187
 None
 1.13A 1tt6B-2pl2A:
undetectable		 1tt6B-2pl2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]

(Haemophilus
influenzae) 		PF02153
(PDH) 		4 LEU A 199
ALA A 175
LEU A 177
SER A 151
 None
None
None
NAD  A 400 (-3.8A)
 1.01A 1tt6B-2pv7A:
undetectable		 1tt6B-2pv7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		4 LYS A 205
LEU A 202
ALA A 204
LEU A 211
 EDO  A 298 (-2.7A)
EDO  A 298 (-4.9A)
None
None
 1.10A 1tt6B-2qhpA:
undetectable		 1tt6B-2qhpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 LEU A 243
ALA A 228
LEU A 253
SER A 254
 None
 1.06A 1tt6B-2xn8A:
undetectable		 1tt6B-2xn8A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 LEU A 190
ALA A 124
LEU A 193
SER A 196
 None
 1.09A 1tt6B-2zcwA:
undetectable		 1tt6B-2zcwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.89A 1tt6B-3aqpA:
undetectable		 1tt6B-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 1.03A 1tt6B-3bdwB:
undetectable		 1tt6B-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS A  46
ALA A  44
LEU A  40
SER A  41
 None
 0.89A 1tt6B-3bjlA:
2.7		 1tt6B-3bjlA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 LYS 1 214
ALA 1 213
LEU 1 229
SER 1 231
 None
 0.99A 1tt6B-3epd1:
1.5		 1tt6B-3epd1:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewn THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF01965
(DJ-1_PfpI) 		4 LEU A 165
ALA A 162
LEU A 160
SER A 157
 None
 1.06A 1tt6B-3ewnA:
undetectable		 1tt6B-3ewnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 0.93A 1tt6B-3eyaA:
undetectable		 1tt6B-3eyaA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.58A 1tt6B-3fc8A:
24.6		 1tt6B-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 129
ALA A 117
LEU A 115
SER A 112
 None
 1.12A 1tt6B-3fj4A:
undetectable		 1tt6B-3fj4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h87 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01402
(RHH_1) 		4 LEU C  24
ALA C  22
LEU C  26
SER C  27
 GOL  C  74 (-4.3A)
None
None
None
 1.03A 1tt6B-3h87C:
undetectable		 1tt6B-3h87C:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		4 LEU A 112
ALA A 142
LEU A 115
SER A 116
 None
None
None
CEW  A 501 (-3.1A)
 1.15A 1tt6B-3humA:
undetectable		 1tt6B-3humA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 LYS A1780
ALA A1779
LEU A1777
SER A1773
 None
 1.00A 1tt6B-3ig3A:
undetectable		 1tt6B-3ig3A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		4 LYS A 152
LEU A 173
LEU A 147
SER A 146
 None
 1.14A 1tt6B-3im9A:
undetectable		 1tt6B-3im9A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 LEU A 113
ALA A 116
LEU A 112
SER A 173
 None
 1.15A 1tt6B-3j09A:
undetectable		 1tt6B-3j09A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		4 LEU A 108
ALA A 106
LEU A 104
SER A 111
 PG6  A 299 (-4.3A)
None
PG6  A 299 ( 4.6A)
None
 1.09A 1tt6B-3jr7A:
undetectable		 1tt6B-3jr7A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A 212
ALA A 252
LEU A 192
SER A 193
 None
 1.13A 1tt6B-3k6kA:
undetectable		 1tt6B-3k6kA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 LYS A  68
LEU A  39
ALA A  65
SER A  44
 None
 1.08A 1tt6B-3kbhA:
undetectable		 1tt6B-3kbhA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 707
ALA A 723
LEU A 710
SER A 713
 None
 1.10A 1tt6B-3nmzA:
undetectable		 1tt6B-3nmzA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 LEU A 481
ALA A 497
LEU A 495
SER A 492
 None
 1.00A 1tt6B-3oeeA:
undetectable		 1tt6B-3oeeA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		4 LEU A 187
ALA A 185
LEU A 189
SER A 190
 None
 1.10A 1tt6B-3p7nA:
undetectable		 1tt6B-3p7nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsj NUDIX HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF00293
(NUDIX) 		4 LEU A 126
ALA A 123
LEU A 121
SER A 118
 None
 1.15A 1tt6B-3qsjA:
undetectable		 1tt6B-3qsjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 311
ALA A 362
LEU A 360
SER A 357
 None
 1.10A 1tt6B-3rzaA:
undetectable		 1tt6B-3rzaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uav PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus cereus) 		PF01048
(PNP_UDP_1) 		4 LYS A  26
LEU A  46
ALA A  29
SER A  58
 None
 1.03A 1tt6B-3uavA:
undetectable		 1tt6B-3uavA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 LYS A  96
LEU A 100
LEU A  35
SER A  34
 NAP  A 291 (-3.1A)
None
None
None
 1.05A 1tt6B-3uxjA:
undetectable		 1tt6B-3uxjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5m PUTATIVE
EXODEOXYRIBONUCLEASE

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		4 LYS A 240
ALA A 248
LEU A 250
SER A   6
 None
 0.95A 1tt6B-4b5mA:
undetectable		 1tt6B-4b5mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxl AS69

(synthetic
construct) 		PF02216
(B) 		4 LYS A  50
ALA A  46
LEU A  44
SER A  41
 None
 1.08A 1tt6B-4bxlA:
undetectable		 1tt6B-4bxlA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH

(Cupriavidus
metallidurans) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		4 LEU A 163
ALA A 161
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 1.08A 1tt6B-4cxfA:
undetectable		 1tt6B-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei0 UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF14725
(DUF4466) 		4 LYS A 213
LEU A 210
ALA A 212
SER A 247
 None
 1.05A 1tt6B-4ei0A:
undetectable		 1tt6B-4ei0A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 LYS A 421
ALA A 417
LEU A  91
SER A  87
 None
 1.09A 1tt6B-4g3jA:
undetectable		 1tt6B-4g3jA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

([Eubacterium]
eligens) 		PF01497
(Peripla_BP_2) 		4 LEU A  91
ALA A  88
LEU A  86
SER A  82
 None
 1.14A 1tt6B-4hn9A:
undetectable		 1tt6B-4hn9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A3523
ALA A3571
LEU A3569
SER A3566
 None
 1.09A 1tt6B-4kc5A:
undetectable		 1tt6B-4kc5A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 LEU A 227
ALA A 229
LEU A 170
SER A 233
 LEU  A 227 ( 0.6A)
ALA  A 229 ( 0.0A)
LEU  A 170 ( 0.5A)
SER  A 233 ( 0.0A)
 1.11A 1tt6B-4kqnA:
undetectable		 1tt6B-4kqnA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 LEU A 179
ALA A 171
LEU A   7
SER A   5
 None
 1.06A 1tt6B-4n2xA:
undetectable		 1tt6B-4n2xA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 LEU A  81
ALA A  98
LEU A  83
SER A  85
 None
 1.04A 1tt6B-4ow2A:
undetectable		 1tt6B-4ow2A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 LEU A 458
ALA A 687
LEU A 651
SER A 648
 None
 1.13A 1tt6B-4ppmA:
undetectable		 1tt6B-4ppmA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		4 LEU B 198
ALA B 195
LEU B 193
SER B 189
 None
 1.11A 1tt6B-4r8uB:
undetectable		 1tt6B-4r8uB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raj HEME OXYGENASE

(Chlamydomonas
reinhardtii) 		PF01126
(Heme_oxygenase) 		4 LEU A  90
ALA A 149
LEU A 184
SER A 180
 None
 1.16A 1tt6B-4rajA:
undetectable		 1tt6B-4rajA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 LEU A1903
ALA A2046
LEU A1854
SER A2031
 None
 1.14A 1tt6B-4x0qA:
undetectable		 1tt6B-4x0qA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 LEU B 400
ALA B 427
LEU B 403
SER B 406
 None
 1.10A 1tt6B-4xmmB:
undetectable		 1tt6B-4xmmB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		4 LEU A 707
ALA A 723
LEU A 710
SER A 713
 None
 1.12A 1tt6B-4yk6A:
undetectable		 1tt6B-4yk6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zey NUCLEAR
RECEPTOR-BINDING
FACTOR 2

(Homo sapiens) 		PF17169
(NRBF2_MIT) 		4 LYS A  35
LEU A  68
ALA A  38
SER A  63
 None
 1.14A 1tt6B-4zeyA:
undetectable		 1tt6B-4zeyA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 LEU L 446
ALA L 379
LEU L 374
SER L 370
 None
 0.96A 1tt6B-5a7dL:
undetectable		 1tt6B-5a7dL:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LYS A 283
ALA A 286
LEU A 306
SER A 307
 None
 1.07A 1tt6B-5ah4A:
undetectable		 1tt6B-5ah4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		4 LEU A 125
ALA A 101
LEU A  91
SER A  56
 None
None
None
SO4  A 201 (-2.8A)
 1.09A 1tt6B-5b3kA:
undetectable		 1tt6B-5b3kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 438
ALA A 462
LEU A 441
SER A 444
 None
 1.09A 1tt6B-5dkuA:
undetectable		 1tt6B-5dkuA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.10A 1tt6B-5dllA:
2.8		 1tt6B-5dllA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqn CYTOCHROME P450
CYP125

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 LEU A 226
ALA A 211
LEU A 236
SER A 237
 None
 1.00A 1tt6B-5dqnA:
undetectable		 1tt6B-5dqnA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5

(Homo sapiens) 		no annotation 4 LEU A 413
ALA A 224
LEU A 228
SER A 326
 None
 1.15A 1tt6B-5emwA:
2.2		 1tt6B-5emwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 LEU B 996
ALA B 994
LEU B1066
SER B1065
 None
 1.07A 1tt6B-5hb4B:
undetectable		 1tt6B-5hb4B:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbr UNCHARACTERIZED
PROTEIN BCAV_2135

(Beutenbergia
cavernae) 		PF12802
(MarR_2) 		4 LEU A  48
ALA A  46
LEU A  50
SER A  51
 None
 0.94A 1tt6B-5jbrA:
undetectable		 1tt6B-5jbrA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt4 CYTOCHROME C'

(Achromobacter
xylosoxidans) 		PF01322
(Cytochrom_C_2) 		4 LEU A  18
ALA A  16
LEU A  51
SER A  52
 None
HEC  A 201 (-3.4A)
None
None
 1.14A 1tt6B-5jt4A:
undetectable		 1tt6B-5jt4A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lty HOMEOBOX PROTEIN
CDX-2

(Homo sapiens) 		PF00046
(Homeobox) 		4 LEU K 223
ALA K 221
LEU K 225
SER K 226
 None
 1.07A 1tt6B-5ltyK:
undetectable		 1tt6B-5ltyK:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		4 LEU C 437
ALA C 278
LEU C 276
SER C 273
 CLA  C 501 ( 4.6A)
CLA  C 507 ( 3.7A)
CLA  C 508 (-4.9A)
CLA  C 505 ( 4.2A)
 1.14A 1tt6B-5mdxC:
undetectable		 1tt6B-5mdxC:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		4 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.70A 1tt6B-5mq6A:
undetectable		 1tt6B-5mq6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)

(Clostridioides
difficile) 		no annotation 4 LEU A 165
ALA A 132
LEU A 130
SER A 127
 None
None
None
SO4  A 420 (-3.4A)
 1.10A 1tt6B-5njlA:
undetectable		 1tt6B-5njlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S25, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LYS a  84
LEU a  81
ALA a  83
SER a  72
 A  E2065 ( 3.4A)
None
None
None
 0.95A 1tt6B-5opta:
undetectable		 1tt6B-5opta:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 LEU A 470
ALA A 513
LEU A 473
SER A 476
 None
 1.10A 1tt6B-5t8vA:
undetectable		 1tt6B-5t8vA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3

(Pseudomonas
aeruginosa) 		PF09615
(Cas_Csy3) 		4 LEU C 214
ALA C 154
LEU C 217
SER C 220
 None
 1.10A 1tt6B-5uz9C:
undetectable		 1tt6B-5uz9C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.14A 1tt6B-5vbbA:
undetectable		 1tt6B-5vbbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 LEU A 601
ALA A 572
LEU A 570
SER A 490
 None
 1.13A 1tt6B-5w81A:
undetectable		 1tt6B-5w81A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 LYS M 114
LEU M 110
LEU M 136
SER M 135
 BR  M 501 (-3.6A)
None
None
None
 1.09A 1tt6B-5wc8M:
undetectable		 1tt6B-5wc8M:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S15A

(Trichomonas
vaginalis) 		PF00410
(Ribosomal_S8) 		4 LEU W  93
ALA W  91
LEU W  94
SER W  96
 None
 1.02A 1tt6B-5xyiW:
undetectable		 1tt6B-5xyiW:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans) 		no annotation 4 LEU A 194
ALA A 197
LEU A 195
SER A 200
 None
 1.11A 1tt6B-6cw5A:
undetectable		 1tt6B-6cw5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 4 LEU A  22
ALA A  20
LEU A  29
SER A  28
 None
 1.08A 1tt6B-6cyzA:
undetectable		 1tt6B-6cyzA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT 6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 LEU M 167
ALA M 292
LEU M 164
SER M 161
 None
 1.05A 1tt6B-6f36M:
undetectable		 1tt6B-6f36M:
19.53